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Network neighborhood for query Sequence : KLOT_HUMAN

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KLOT_HUMAN
SwissProt Accessions	Q9UEF7, Q5VZ95, Q96KV5, Q96KW5, Q9UEI9, Q9Y4F0	Gene names	KL
Domain Architecture	No domain graphic available
Description	Klotho precursor (EC 3.2.1.31) [Contains: Klotho peptide].
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

KLOTB_HUMAN
θ value	0 (rank : 1)	NC score	0.985938 (rank : 3)
Query Neighborhood Hits	14	Target Neighborhood Hits	9	Shared Neighborhood Hits	8
SwissProt Accessions	Q86Z14	Gene names	KLB
Domain Architecture	No domain graphic available
Description	Beta klotho (BetaKlotho) (Klotho beta-like protein).

KLOTB_MOUSE
θ value	0 (rank : 2)	NC score	0.985646 (rank : 4)
Query Neighborhood Hits	14	Target Neighborhood Hits	11	Shared Neighborhood Hits	8
SwissProt Accessions	Q99N32, Q920J2, Q99N31	Gene names	Klb, Betakl
Domain Architecture	No domain graphic available
Description	Beta klotho (BetaKlotho) (Klotho beta-like protein).

KLOT_HUMAN
θ value	0 (rank : 3)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	14	Target Neighborhood Hits	14	Shared Neighborhood Hits	14
SwissProt Accessions	Q9UEF7, Q5VZ95, Q96KV5, Q96KW5, Q9UEI9, Q9Y4F0	Gene names	KL
Domain Architecture	No domain graphic available
Description	Klotho precursor (EC 3.2.1.31) [Contains: Klotho peptide].

KLOT_MOUSE
θ value	0 (rank : 4)	NC score	0.999590 (rank : 2)
Query Neighborhood Hits	14	Target Neighborhood Hits	17	Shared Neighborhood Hits	12
SwissProt Accessions	O35082, O70175, O70621	Gene names	Kl
Domain Architecture	No domain graphic available
Description	Klotho precursor (EC 3.2.1.31) [Contains: Klotho peptide].

LPH_HUMAN
θ value	0 (rank : 5)	NC score	0.965022 (rank : 5)
Query Neighborhood Hits	14	Target Neighborhood Hits	27	Shared Neighborhood Hits	8
SwissProt Accessions	P09848	Gene names	LCT, LPH
Domain Architecture
Description	Lactase-phlorizin hydrolase precursor (Lactase-glycosylceramidase) [Includes: Lactase (EC 3.2.1.108); Phlorizin hydrolase (EC 3.2.1.62)].

LCTL_HUMAN
θ value	1.44246e-98 (rank : 6)	NC score	0.946432 (rank : 7)
Query Neighborhood Hits	14	Target Neighborhood Hits	11	Shared Neighborhood Hits	8
SwissProt Accessions	Q6UWM7	Gene names	LCTL, KLPH
Domain Architecture	No domain graphic available
Description	Lactase-like protein precursor (Klotho/lactase-phlorizin hydrolase- related protein).

LCTL_MOUSE
θ value	1.65039e-94 (rank : 7)	NC score	0.944267 (rank : 8)
Query Neighborhood Hits	14	Target Neighborhood Hits	11	Shared Neighborhood Hits	8
SwissProt Accessions	Q8K1F9, Q8BPR1, Q8K2M9	Gene names	Lctl, Klph
Domain Architecture	No domain graphic available
Description	Lactase-like protein precursor (Klotho/lactase-phlorizin hydrolase- related protein).

GBA3_HUMAN
θ value	2.15548e-94 (rank : 8)	NC score	0.957772 (rank : 6)
Query Neighborhood Hits	14	Target Neighborhood Hits	12	Shared Neighborhood Hits	8
SwissProt Accessions	Q9H227, Q3MIH4, Q53GG8, Q6NSF4, Q8NHT8, Q9H3T4, Q9H4C6	Gene names	GBA3, CBG, CBGL1
Domain Architecture	No domain graphic available
Description	Cytosolic beta-glucosidase (EC 3.2.1.21) (Cytosolic beta-glucosidase- like protein 1).

SCAM1_HUMAN
θ value	0.813845 (rank : 9)	NC score	0.029924 (rank : 10)
Query Neighborhood Hits	14	Target Neighborhood Hits	27	Shared Neighborhood Hits	4
SwissProt Accessions	O15126, O43587, Q96BX1, Q96QK5	Gene names	SCAMP1, SCAMP
Domain Architecture
Description	Secretory carrier-associated membrane protein 1 (Secretory carrier membrane protein 1).

SCAM1_MOUSE
θ value	1.38821 (rank : 10)	NC score	0.030640 (rank : 9)
Query Neighborhood Hits	14	Target Neighborhood Hits	24	Shared Neighborhood Hits	4
SwissProt Accessions	Q8K021	Gene names	Scamp1
Domain Architecture
Description	Secretory carrier-associated membrane protein 1 (Secretory carrier membrane protein 1).

ATS5_HUMAN
θ value	4.03905 (rank : 11)	NC score	0.007793 (rank : 12)
Query Neighborhood Hits	14	Target Neighborhood Hits	141	Shared Neighborhood Hits	4
SwissProt Accessions	Q9UNA0, Q9UKP2	Gene names	ADAMTS5, ADAMTS11, ADMP2
Domain Architecture
Description	ADAMTS-5 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase with thrombospondin motifs 5) (ADAM-TS 5) (ADAM-TS5) (Aggrecanase-2) (ADMP-2) (ADAM-TS 11).

PRI2_MOUSE
θ value	5.27518 (rank : 12)	NC score	0.013521 (rank : 11)
Query Neighborhood Hits	14	Target Neighborhood Hits	10	Shared Neighborhood Hits	2
SwissProt Accessions	P33610, Q3U4Z3	Gene names	Prim2
Domain Architecture
Description	DNA primase large subunit (EC 2.7.7.-) (DNA primase 58 kDa subunit) (p58).

ATS5_MOUSE
θ value	6.88961 (rank : 13)	NC score	0.006311 (rank : 13)
Query Neighborhood Hits	14	Target Neighborhood Hits	147	Shared Neighborhood Hits	4
SwissProt Accessions	Q9R001	Gene names	Adamts5
Domain Architecture
Description	ADAMTS-5 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase with thrombospondin motifs 5) (ADAM-TS 5) (ADAM-TS5) (Aggrecanase-2) (ADMP-2) (Implantin).

AP4E1_MOUSE
θ value	8.99809 (rank : 14)	NC score	0.005510 (rank : 14)
Query Neighborhood Hits	14	Target Neighborhood Hits	59	Shared Neighborhood Hits	2
SwissProt Accessions	Q80V94	Gene names	Ap4e1
Domain Architecture	No domain graphic available
Description	AP-4 complex subunit epsilon-1 (Adapter-related protein complex 4 epsilon-1 subunit) (Epsilon subunit of AP-4) (AP-4 adapter complex epsilon subunit).

Hits sorted by NC score

KLOT_HUMAN
NC score	0.999962 (rank : 1)	θ value	0 (rank : 3)
Query Neighborhood Hits	14	Target Neighborhood Hits	14	Shared Neighborhood Hits	14
SwissProt Accessions	Q9UEF7, Q5VZ95, Q96KV5, Q96KW5, Q9UEI9, Q9Y4F0	Gene names	KL
Domain Architecture	No domain graphic available
Description	Klotho precursor (EC 3.2.1.31) [Contains: Klotho peptide].

KLOT_MOUSE
NC score	0.999590 (rank : 2)	θ value	0 (rank : 4)
Query Neighborhood Hits	14	Target Neighborhood Hits	17	Shared Neighborhood Hits	12
SwissProt Accessions	O35082, O70175, O70621	Gene names	Kl
Domain Architecture	No domain graphic available
Description	Klotho precursor (EC 3.2.1.31) [Contains: Klotho peptide].

KLOTB_HUMAN
NC score	0.985938 (rank : 3)	θ value	0 (rank : 1)
Query Neighborhood Hits	14	Target Neighborhood Hits	9	Shared Neighborhood Hits	8
SwissProt Accessions	Q86Z14	Gene names	KLB
Domain Architecture	No domain graphic available
Description	Beta klotho (BetaKlotho) (Klotho beta-like protein).

KLOTB_MOUSE
NC score	0.985646 (rank : 4)	θ value	0 (rank : 2)
Query Neighborhood Hits	14	Target Neighborhood Hits	11	Shared Neighborhood Hits	8
SwissProt Accessions	Q99N32, Q920J2, Q99N31	Gene names	Klb, Betakl
Domain Architecture	No domain graphic available
Description	Beta klotho (BetaKlotho) (Klotho beta-like protein).

LPH_HUMAN
NC score	0.965022 (rank : 5)	θ value	0 (rank : 5)
Query Neighborhood Hits	14	Target Neighborhood Hits	27	Shared Neighborhood Hits	8
SwissProt Accessions	P09848	Gene names	LCT, LPH
Domain Architecture
Description	Lactase-phlorizin hydrolase precursor (Lactase-glycosylceramidase) [Includes: Lactase (EC 3.2.1.108); Phlorizin hydrolase (EC 3.2.1.62)].

GBA3_HUMAN
NC score	0.957772 (rank : 6)	θ value	2.15548e-94 (rank : 8)
Query Neighborhood Hits	14	Target Neighborhood Hits	12	Shared Neighborhood Hits	8
SwissProt Accessions	Q9H227, Q3MIH4, Q53GG8, Q6NSF4, Q8NHT8, Q9H3T4, Q9H4C6	Gene names	GBA3, CBG, CBGL1
Domain Architecture	No domain graphic available
Description	Cytosolic beta-glucosidase (EC 3.2.1.21) (Cytosolic beta-glucosidase- like protein 1).

LCTL_HUMAN
NC score	0.946432 (rank : 7)	θ value	1.44246e-98 (rank : 6)
Query Neighborhood Hits	14	Target Neighborhood Hits	11	Shared Neighborhood Hits	8
SwissProt Accessions	Q6UWM7	Gene names	LCTL, KLPH
Domain Architecture	No domain graphic available
Description	Lactase-like protein precursor (Klotho/lactase-phlorizin hydrolase- related protein).

LCTL_MOUSE
NC score	0.944267 (rank : 8)	θ value	1.65039e-94 (rank : 7)
Query Neighborhood Hits	14	Target Neighborhood Hits	11	Shared Neighborhood Hits	8
SwissProt Accessions	Q8K1F9, Q8BPR1, Q8K2M9	Gene names	Lctl, Klph
Domain Architecture	No domain graphic available
Description	Lactase-like protein precursor (Klotho/lactase-phlorizin hydrolase- related protein).

SCAM1_MOUSE
NC score	0.030640 (rank : 9)	θ value	1.38821 (rank : 10)
Query Neighborhood Hits	14	Target Neighborhood Hits	24	Shared Neighborhood Hits	4
SwissProt Accessions	Q8K021	Gene names	Scamp1
Domain Architecture
Description	Secretory carrier-associated membrane protein 1 (Secretory carrier membrane protein 1).

SCAM1_HUMAN
NC score	0.029924 (rank : 10)	θ value	0.813845 (rank : 9)
Query Neighborhood Hits	14	Target Neighborhood Hits	27	Shared Neighborhood Hits	4
SwissProt Accessions	O15126, O43587, Q96BX1, Q96QK5	Gene names	SCAMP1, SCAMP
Domain Architecture
Description	Secretory carrier-associated membrane protein 1 (Secretory carrier membrane protein 1).

PRI2_MOUSE
NC score	0.013521 (rank : 11)	θ value	5.27518 (rank : 12)
Query Neighborhood Hits	14	Target Neighborhood Hits	10	Shared Neighborhood Hits	2
SwissProt Accessions	P33610, Q3U4Z3	Gene names	Prim2
Domain Architecture
Description	DNA primase large subunit (EC 2.7.7.-) (DNA primase 58 kDa subunit) (p58).

ATS5_HUMAN
NC score	0.007793 (rank : 12)	θ value	4.03905 (rank : 11)
Query Neighborhood Hits	14	Target Neighborhood Hits	141	Shared Neighborhood Hits	4
SwissProt Accessions	Q9UNA0, Q9UKP2	Gene names	ADAMTS5, ADAMTS11, ADMP2
Domain Architecture
Description	ADAMTS-5 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase with thrombospondin motifs 5) (ADAM-TS 5) (ADAM-TS5) (Aggrecanase-2) (ADMP-2) (ADAM-TS 11).

ATS5_MOUSE
NC score	0.006311 (rank : 13)	θ value	6.88961 (rank : 13)
Query Neighborhood Hits	14	Target Neighborhood Hits	147	Shared Neighborhood Hits	4
SwissProt Accessions	Q9R001	Gene names	Adamts5
Domain Architecture
Description	ADAMTS-5 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase with thrombospondin motifs 5) (ADAM-TS 5) (ADAM-TS5) (Aggrecanase-2) (ADMP-2) (Implantin).

AP4E1_MOUSE
NC score	0.005510 (rank : 14)	θ value	8.99809 (rank : 14)
Query Neighborhood Hits	14	Target Neighborhood Hits	59	Shared Neighborhood Hits	2
SwissProt Accessions	Q80V94	Gene names	Ap4e1
Domain Architecture	No domain graphic available
Description	AP-4 complex subunit epsilon-1 (Adapter-related protein complex 4 epsilon-1 subunit) (Epsilon subunit of AP-4) (AP-4 adapter complex epsilon subunit).