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Network neighborhood for query Sequence : IL2RA_HUMAN

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IL2RA_HUMAN
SwissProt Accessions	P01589	Gene names	IL2RA
Domain Architecture
Description	Interleukin-2 receptor alpha chain precursor (IL-2 receptor alpha subunit) (IL-2-RA) (IL2-RA) (p55) (TAC antigen) (CD25 antigen).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

IL2RA_HUMAN
θ value	1.51632e-156 (rank : 1)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	32	Target Neighborhood Hits	32	Shared Neighborhood Hits	32
SwissProt Accessions	P01589	Gene names	IL2RA
Domain Architecture
Description	Interleukin-2 receptor alpha chain precursor (IL-2 receptor alpha subunit) (IL-2-RA) (IL2-RA) (p55) (TAC antigen) (CD25 antigen).

IL2RA_MOUSE
θ value	5.32145e-85 (rank : 2)	NC score	0.950826 (rank : 2)
Query Neighborhood Hits	32	Target Neighborhood Hits	21	Shared Neighborhood Hits	9
SwissProt Accessions	P01590, Q61731	Gene names	Il2ra, Il2r
Domain Architecture
Description	Interleukin-2 receptor alpha chain precursor (IL-2 receptor alpha subunit) (IL-2-RA) (IL2-RA) (p55) (CD25 antigen).

CR2_MOUSE
θ value	0.00869519 (rank : 3)	NC score	0.166772 (rank : 5)
Query Neighborhood Hits	32	Target Neighborhood Hits	101	Shared Neighborhood Hits	20
SwissProt Accessions	P19070	Gene names	Cr2
Domain Architecture
Description	Complement receptor type 2 precursor (Cr2) (Complement C3d receptor) (CD21 antigen).

CR2_HUMAN
θ value	0.0736092 (rank : 4)	NC score	0.160477 (rank : 8)
Query Neighborhood Hits	32	Target Neighborhood Hits	89	Shared Neighborhood Hits	21
SwissProt Accessions	P20023, Q13866, Q14212	Gene names	CR2, C3DR
Domain Architecture
Description	Complement receptor type 2 precursor (Cr2) (Complement C3d receptor) (Epstein-Barr virus receptor) (EBV receptor) (CD21 antigen).

DAF1_MOUSE
θ value	0.125558 (rank : 5)	NC score	0.166934 (rank : 4)
Query Neighborhood Hits	32	Target Neighborhood Hits	204	Shared Neighborhood Hits	23
SwissProt Accessions	Q61475, P97732, Q61397	Gene names	Cd55a, Daf1
Domain Architecture
Description	Complement decay-accelerating factor, GPI-anchored precursor (DAF-GPI) (CD55 antigen).

DAF2_MOUSE
θ value	0.125558 (rank : 6)	NC score	0.169526 (rank : 3)
Query Neighborhood Hits	32	Target Neighborhood Hits	114	Shared Neighborhood Hits	22
SwissProt Accessions	Q61476	Gene names	Cd55b, Daf2
Domain Architecture
Description	Complement decay-accelerating factor transmembrane isoform precursor (DAF-TM) (CD55 antigen).

C4BP_MOUSE
θ value	0.163984 (rank : 7)	NC score	0.161163 (rank : 7)
Query Neighborhood Hits	32	Target Neighborhood Hits	91	Shared Neighborhood Hits	21
SwissProt Accessions	P08607	Gene names	C4bpa, C4bp
Domain Architecture
Description	C4b-binding protein precursor (C4bp).

DAF_HUMAN
θ value	0.279714 (rank : 8)	NC score	0.163117 (rank : 6)
Query Neighborhood Hits	32	Target Neighborhood Hits	97	Shared Neighborhood Hits	20
SwissProt Accessions	P08174, P09679, P78361	Gene names	CD55, CR, DAF
Domain Architecture
Description	Complement decay-accelerating factor precursor (CD55 antigen).

ZP3R_MOUSE
θ value	0.47712 (rank : 9)	NC score	0.153039 (rank : 11)
Query Neighborhood Hits	32	Target Neighborhood Hits	81	Shared Neighborhood Hits	20
SwissProt Accessions	Q60736	Gene names	Zp3r, Sp56
Domain Architecture
Description	Zona pellucida sperm-binding protein 3 receptor precursor (Sperm fertilization protein 56) (sp56).

CFAH_HUMAN
θ value	0.62314 (rank : 10)	NC score	0.139987 (rank : 12)
Query Neighborhood Hits	32	Target Neighborhood Hits	101	Shared Neighborhood Hits	21
SwissProt Accessions	P08603, P78435, Q14570, Q38G77, Q5TFM3, Q8N708, Q9NU86	Gene names	CFH, HF, HF1
Domain Architecture
Description	Complement factor H precursor (H factor 1).

CR1_HUMAN
θ value	0.813845 (rank : 11)	NC score	0.157306 (rank : 9)
Query Neighborhood Hits	32	Target Neighborhood Hits	108	Shared Neighborhood Hits	22
SwissProt Accessions	P17927, Q16745, Q9UQV2	Gene names	CR1, C3BR
Domain Architecture
Description	Complement receptor type 1 precursor (C3b/C4b receptor) (CD35 antigen).

CRRY_MOUSE
θ value	0.813845 (rank : 12)	NC score	0.155551 (rank : 10)
Query Neighborhood Hits	32	Target Neighborhood Hits	84	Shared Neighborhood Hits	20
SwissProt Accessions	Q64735, Q3TV30, Q58E68, Q61447, Q61449, Q8CF59, Q8K328	Gene names	Crry, Cry
Domain Architecture	No domain graphic available
Description	Complement regulatory protein Crry precursor (Protein p65).

CFAH_MOUSE
θ value	1.38821 (rank : 13)	NC score	0.137328 (rank : 13)
Query Neighborhood Hits	32	Target Neighborhood Hits	112	Shared Neighborhood Hits	21
SwissProt Accessions	P06909	Gene names	Cfh, Hf1
Domain Architecture
Description	Complement factor H precursor (Protein beta-1-H).

CSMD1_HUMAN
θ value	1.38821 (rank : 14)	NC score	0.104853 (rank : 18)
Query Neighborhood Hits	32	Target Neighborhood Hits	176	Shared Neighborhood Hits	21
SwissProt Accessions	Q96PZ7, Q96QU9, Q96RM4	Gene names	CSMD1, KIAA1890
Domain Architecture
Description	CUB and sushi domain-containing protein 1 precursor (CUB and sushi multiple domains protein 1).

CS1B_MOUSE
θ value	1.81305 (rank : 15)	NC score	0.033735 (rank : 51)
Query Neighborhood Hits	32	Target Neighborhood Hits	361	Shared Neighborhood Hits	20
SwissProt Accessions	Q8CFG8	Gene names	C1sb, C1s
Domain Architecture	No domain graphic available
Description	Complement C1s-B subcomponent precursor (EC 3.4.21.42) (C1 esterase) [Contains: Complement C1s-B subcomponent heavy chain; Complement C1s-B subcomponent light chain].

NR1D2_HUMAN
θ value	1.81305 (rank : 16)	NC score	0.022922 (rank : 54)
Query Neighborhood Hits	32	Target Neighborhood Hits	115	Shared Neighborhood Hits	3
SwissProt Accessions	Q14995, O00402, Q86XD4	Gene names	NR1D2
Domain Architecture
Description	Orphan nuclear receptor NR1D2 (Rev-erb-beta) (EAR-1R) (Orphan nuclear hormone receptor BD73).

I15RA_MOUSE
θ value	2.36792 (rank : 17)	NC score	0.069539 (rank : 39)
Query Neighborhood Hits	32	Target Neighborhood Hits	26	Shared Neighborhood Hits	10
SwissProt Accessions	Q60819, Q80Z90, Q80Z91, Q80Z92, Q8R5E4	Gene names	Il15ra
Domain Architecture	No domain graphic available
Description	Interleukin-15 receptor alpha chain precursor (IL-15R-alpha) (IL- 15RA).

NR1D2_MOUSE
θ value	2.36792 (rank : 18)	NC score	0.022075 (rank : 55)
Query Neighborhood Hits	32	Target Neighborhood Hits	109	Shared Neighborhood Hits	3
SwissProt Accessions	Q60674, Q60646	Gene names	Nr1d2
Domain Architecture
Description	Orphan nuclear receptor NR1D2 (Rev-erb-beta) (Orphan nuclear receptor RVR).

SUSD4_MOUSE
θ value	2.36792 (rank : 19)	NC score	0.114630 (rank : 17)
Query Neighborhood Hits	32	Target Neighborhood Hits	122	Shared Neighborhood Hits	19
SwissProt Accessions	Q8BH32, Q8VC43	Gene names	Susd4
Domain Architecture	No domain graphic available
Description	Sushi domain-containing protein 4 precursor.

CS1A_MOUSE
θ value	3.0926 (rank : 20)	NC score	0.033051 (rank : 52)
Query Neighborhood Hits	32	Target Neighborhood Hits	360	Shared Neighborhood Hits	20
SwissProt Accessions	Q8CG14, Q8BJC4, Q8CH28, Q8VBY4	Gene names	C1sa, C1s
Domain Architecture	No domain graphic available
Description	Complement C1s-A subcomponent precursor (EC 3.4.21.42) (C1 esterase) [Contains: Complement C1s-A subcomponent heavy chain; Complement C1s-A subcomponent light chain].

TNR6A_HUMAN
θ value	3.0926 (rank : 21)	NC score	0.031371 (rank : 53)
Query Neighborhood Hits	32	Target Neighborhood Hits	343	Shared Neighborhood Hits	2
SwissProt Accessions	Q8NDV7, O15408, Q658L5, Q6NVB5, Q8NEZ0, Q8TBT8, Q8TCR0, Q9NV59, Q9P268	Gene names	TNRC6A, CAGH26, KIAA1460, TNRC6
Domain Architecture	No domain graphic available
Description	Trinucleotide repeat-containing gene 6A protein (CAG repeat protein 26) (Glycine-tryptophan protein of 182 kDa) (GW182 autoantigen) (Protein GW1) (EMSY interactor protein).

IC1_HUMAN
θ value	4.03905 (rank : 22)	NC score	0.012843 (rank : 59)
Query Neighborhood Hits	32	Target Neighborhood Hits	99	Shared Neighborhood Hits	3
SwissProt Accessions	P05155, Q547W3, Q59EI5, Q96FE0	Gene names	SERPING1, C1IN, C1NH
Domain Architecture
Description	Plasma protease C1 inhibitor precursor (C1 Inh) (C1Inh) (C1 esterase inhibitor) (C1-inhibiting factor).

PGCA_HUMAN
θ value	4.03905 (rank : 23)	NC score	0.034291 (rank : 50)
Query Neighborhood Hits	32	Target Neighborhood Hits	821	Shared Neighborhood Hits	19
SwissProt Accessions	P16112, Q13650, Q9UCP4, Q9UCP5, Q9UDE0	Gene names	AGC1, CSPG1
Domain Architecture
Description	Aggrecan core protein precursor (Cartilage-specific proteoglycan core protein) (CSPCP) (Chondroitin sulfate proteoglycan core protein 1) [Contains: Aggrecan core protein 2].

CSMD1_MOUSE
θ value	6.88961 (rank : 24)	NC score	0.101656 (rank : 24)
Query Neighborhood Hits	32	Target Neighborhood Hits	193	Shared Neighborhood Hits	22
SwissProt Accessions	Q923L3, Q8BUV1, Q8BYQ3	Gene names	Csmd1
Domain Architecture
Description	CUB and sushi domain-containing protein 1 precursor (CUB and sushi multiple domains protein 1).

CSMD2_HUMAN
θ value	6.88961 (rank : 25)	NC score	0.096457 (rank : 29)
Query Neighborhood Hits	32	Target Neighborhood Hits	188	Shared Neighborhood Hits	21
SwissProt Accessions	Q7Z408, Q5VT59, Q8N963, Q96Q03, Q9H4V7, Q9H4V8, Q9H4V9, Q9H4W0, Q9H4W1, Q9H4W2, Q9H4W3, Q9H4W4, Q9HCY5, Q9HCY6, Q9HCY7	Gene names	CSMD2, KIAA1884
Domain Architecture
Description	CUB and sushi domain-containing protein 2 (CUB and sushi multiple domains protein 2).

BAP1_MOUSE
θ value	8.99809 (rank : 26)	NC score	0.014780 (rank : 58)
Query Neighborhood Hits	32	Target Neighborhood Hits	118	Shared Neighborhood Hits	2
SwissProt Accessions	Q99PU7, Q6ZQE6	Gene names	Bap1, Kiaa0272
Domain Architecture	No domain graphic available
Description	Ubiquitin carboxyl-terminal hydrolase BAP1 (EC 3.4.19.12) (BRCA1- associated protein 1) (Ubiquitin C-terminal hydrolase X4) (UCH-X4).

CSMD3_HUMAN
θ value	8.99809 (rank : 27)	NC score	0.098832 (rank : 28)
Query Neighborhood Hits	32	Target Neighborhood Hits	199	Shared Neighborhood Hits	21
SwissProt Accessions	Q7Z407, Q96PZ3	Gene names	CSMD3, KIAA1894
Domain Architecture
Description	CUB and sushi domain-containing protein 3 precursor (CUB and sushi multiple domains protein 3).

EMR3_HUMAN
θ value	8.99809 (rank : 28)	NC score	0.006994 (rank : 61)
Query Neighborhood Hits	32	Target Neighborhood Hits	245	Shared Neighborhood Hits	4
SwissProt Accessions	Q9BY15	Gene names	EMR3
Domain Architecture
Description	EGF-like module-containing mucin-like hormone receptor-like 3 precursor (EGF-like module-containing mucin-like receptor EMR3).

PRG4_MOUSE
θ value	8.99809 (rank : 29)	NC score	0.010318 (rank : 60)
Query Neighborhood Hits	32	Target Neighborhood Hits	624	Shared Neighborhood Hits	4
SwissProt Accessions	Q9JM99, Q3UEL1, Q3V198	Gene names	Prg4, Msf, Szp
Domain Architecture	No domain graphic available
Description	Proteoglycan-4 precursor (Lubricin) (Megakaryocyte-stimulating factor) (Superficial zone proteoglycan) [Contains: Proteoglycan-4 C-terminal part].

SN1L2_MOUSE
θ value	8.99809 (rank : 30)	NC score	0.000264 (rank : 62)
Query Neighborhood Hits	32	Target Neighborhood Hits	944	Shared Neighborhood Hits	2
SwissProt Accessions	Q8CFH6	Gene names	Snf1lk2, Sik2
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase SNF1-like kinase 2 (EC 2.7.11.1) (Salt-inducible kinase 2).

VINC_HUMAN
θ value	8.99809 (rank : 31)	NC score	0.021972 (rank : 56)
Query Neighborhood Hits	32	Target Neighborhood Hits	145	Shared Neighborhood Hits	3
SwissProt Accessions	P18206, Q16450, Q5SWX2, Q7Z3B8, Q8IXU7	Gene names	VCL
Domain Architecture
Description	Vinculin (Metavinculin).

VINC_MOUSE
θ value	8.99809 (rank : 32)	NC score	0.020490 (rank : 57)
Query Neighborhood Hits	32	Target Neighborhood Hits	135	Shared Neighborhood Hits	3
SwissProt Accessions	Q64727, Q8BP32, Q8BS46, Q922C5, Q922D9	Gene names	Vcl
Domain Architecture
Description	Vinculin (Metavinculin).

APOH_HUMAN
θ value	θ > 10 (rank : 33)	NC score	0.102151 (rank : 20)
Query Neighborhood Hits	32	Target Neighborhood Hits	75	Shared Neighborhood Hits	18
SwissProt Accessions	P02749, Q9UCN7	Gene names	APOH, B2G1
Domain Architecture
Description	Beta-2-glycoprotein 1 precursor (Beta-2-glycoprotein I) (Apolipoprotein H) (Apo-H) (B2GPI) (Beta(2)GPI) (Activated protein C- binding protein) (APC inhibitor) (Anticardiolipin cofactor).

APOH_MOUSE
θ value	θ > 10 (rank : 34)	NC score	0.104196 (rank : 19)
Query Neighborhood Hits	32	Target Neighborhood Hits	74	Shared Neighborhood Hits	18
SwissProt Accessions	Q01339	Gene names	Apoh, B2gp1
Domain Architecture
Description	Beta-2-glycoprotein 1 precursor (Beta-2-glycoprotein I) (Apolipoprotein H) (Apo-H) (B2GPI) (Beta(2)GPI) (Activated protein C- binding protein) (APC inhibitor).

C4BB_HUMAN
θ value	θ > 10 (rank : 35)	NC score	0.102111 (rank : 22)
Query Neighborhood Hits	32	Target Neighborhood Hits	77	Shared Neighborhood Hits	18
SwissProt Accessions	P20851	Gene names	C4BPB
Domain Architecture
Description	C4b-binding protein beta chain precursor.

C4BP_HUMAN
θ value	θ > 10 (rank : 36)	NC score	0.135125 (rank : 14)
Query Neighborhood Hits	32	Target Neighborhood Hits	92	Shared Neighborhood Hits	19
SwissProt Accessions	P04003	Gene names	C4BPA, C4BP
Domain Architecture
Description	C4b-binding protein alpha chain precursor (C4bp) (Proline-rich protein) (PRP).

CFAB_HUMAN
θ value	θ > 10 (rank : 37)	NC score	0.050100 (rank : 49)
Query Neighborhood Hits	32	Target Neighborhood Hits	251	Shared Neighborhood Hits	19
SwissProt Accessions	P00751, O15006, Q29944, Q96HX6, Q9BTF5, Q9BX92	Gene names	CFB, BF
Domain Architecture
Description	Complement factor B precursor (EC 3.4.21.47) (C3/C5 convertase) (Properdin factor B) (Glycine-rich beta glycoprotein) (GBG) (PBF2) [Contains: Complement factor B Ba fragment; Complement factor B Bb fragment].

CFAB_MOUSE
θ value	θ > 10 (rank : 38)	NC score	0.050997 (rank : 47)
Query Neighborhood Hits	32	Target Neighborhood Hits	262	Shared Neighborhood Hits	19
SwissProt Accessions	P04186	Gene names	Cfb, Bf, H2-Bf
Domain Architecture
Description	Complement factor B precursor (EC 3.4.21.47) (C3/C5 convertase) [Contains: Complement factor B Ba fragment; Complement factor B Bb fragment].

CO2_HUMAN
θ value	θ > 10 (rank : 39)	NC score	0.051779 (rank : 46)
Query Neighborhood Hits	32	Target Neighborhood Hits	258	Shared Neighborhood Hits	19
SwissProt Accessions	P06681, O19694, Q13904	Gene names	C2
Domain Architecture
Description	Complement C2 precursor (EC 3.4.21.43) (C3/C5 convertase) [Contains: Complement C2b fragment; Complement C2a fragment].

CO7_HUMAN
θ value	θ > 10 (rank : 40)	NC score	0.052290 (rank : 45)
Query Neighborhood Hits	32	Target Neighborhood Hits	278	Shared Neighborhood Hits	16
SwissProt Accessions	P10643, Q6P3T5, Q92489	Gene names	C7
Domain Architecture
Description	Complement component C7 precursor.

F13B_HUMAN
θ value	θ > 10 (rank : 41)	NC score	0.102126 (rank : 21)
Query Neighborhood Hits	32	Target Neighborhood Hits	84	Shared Neighborhood Hits	17
SwissProt Accessions	P05160	Gene names	F13B
Domain Architecture
Description	Coagulation factor XIII B chain precursor (Protein-glutamine gamma- glutamyltransferase B chain) (Transglutaminase B chain) (Fibrin- stabilizing factor B subunit).

F13B_MOUSE
θ value	θ > 10 (rank : 42)	NC score	0.100566 (rank : 25)
Query Neighborhood Hits	32	Target Neighborhood Hits	93	Shared Neighborhood Hits	17
SwissProt Accessions	Q07968	Gene names	F13b, Cf13b
Domain Architecture
Description	Coagulation factor XIII B chain precursor (Protein-glutamine gamma- glutamyltransferase B chain) (Transglutaminase B chain).

FHR1_HUMAN
θ value	θ > 10 (rank : 43)	NC score	0.099085 (rank : 27)
Query Neighborhood Hits	32	Target Neighborhood Hits	80	Shared Neighborhood Hits	20
SwissProt Accessions	Q03591, Q9UJ17	Gene names	CFHL1, CFHL, FHR1, HFL1
Domain Architecture
Description	Complement factor H-related protein 1 precursor (FHR-1) (H factor-like protein 1) (H-factor-like 1) (H36).

FHR2_HUMAN
θ value	θ > 10 (rank : 44)	NC score	0.084797 (rank : 33)
Query Neighborhood Hits	32	Target Neighborhood Hits	63	Shared Neighborhood Hits	19
SwissProt Accessions	P36980, Q14310	Gene names	CFHL2, FHR2, HFL3
Domain Architecture
Description	Complement factor H-related protein 2 precursor (FHR-2) (H factor-like protein 2) (H factor-like 3) (DDESK59).

FHR3_HUMAN
θ value	θ > 10 (rank : 45)	NC score	0.086172 (rank : 32)
Query Neighborhood Hits	32	Target Neighborhood Hits	74	Shared Neighborhood Hits	19
SwissProt Accessions	Q02985, Q9UJ16	Gene names	CFHL3, FHR3
Domain Architecture
Description	Complement factor H-related protein 3 precursor (FHR-3) (H factor-like protein 3) (DOWN16).

FHR4_HUMAN
θ value	θ > 10 (rank : 46)	NC score	0.087695 (rank : 31)
Query Neighborhood Hits	32	Target Neighborhood Hits	75	Shared Neighborhood Hits	19
SwissProt Accessions	Q92496, Q9UJY6	Gene names	CFHL4, FHR4
Domain Architecture
Description	Complement factor H-related protein 4 precursor (FHR-4).

FHR5_HUMAN
θ value	θ > 10 (rank : 47)	NC score	0.099255 (rank : 26)
Query Neighborhood Hits	32	Target Neighborhood Hits	77	Shared Neighborhood Hits	19
SwissProt Accessions	Q9BXR6	Gene names	CFHL5, FHR5
Domain Architecture
Description	Complement factor H-related protein 5 precursor (FHR-5).

LYAM2_HUMAN
θ value	θ > 10 (rank : 48)	NC score	0.081491 (rank : 36)
Query Neighborhood Hits	32	Target Neighborhood Hits	394	Shared Neighborhood Hits	19
SwissProt Accessions	P16581, P16111	Gene names	SELE, ELAM1
Domain Architecture
Description	E-selectin precursor (Endothelial leukocyte adhesion molecule 1) (ELAM-1) (Leukocyte-endothelial cell adhesion molecule 2) (LECAM2) (CD62E antigen).

LYAM2_MOUSE
θ value	θ > 10 (rank : 49)	NC score	0.077039 (rank : 37)
Query Neighborhood Hits	32	Target Neighborhood Hits	420	Shared Neighborhood Hits	19
SwissProt Accessions	Q00690	Gene names	Sele, Elam-1
Domain Architecture
Description	E-selectin precursor (Endothelial leukocyte adhesion molecule 1) (ELAM-1) (Leukocyte-endothelial cell adhesion molecule 2) (LECAM2) (CD62E antigen).

LYAM3_HUMAN
θ value	θ > 10 (rank : 50)	NC score	0.084756 (rank : 34)
Query Neighborhood Hits	32	Target Neighborhood Hits	378	Shared Neighborhood Hits	19
SwissProt Accessions	P16109, Q8IVD1	Gene names	SELP, GMRP
Domain Architecture
Description	P-selectin precursor (Granule membrane protein 140) (GMP-140) (PADGEM) (Leukocyte-endothelial cell adhesion molecule 3) (LECAM3) (CD62P antigen).

LYAM3_MOUSE
θ value	θ > 10 (rank : 51)	NC score	0.083929 (rank : 35)
Query Neighborhood Hits	32	Target Neighborhood Hits	390	Shared Neighborhood Hits	19
SwissProt Accessions	Q01102	Gene names	Selp, Grmp
Domain Architecture
Description	P-selectin precursor (Granule membrane protein 140) (GMP-140) (PADGEM) (Leukocyte-endothelial cell adhesion molecule 3) (LECAM3) (CD62P antigen).

MCP_HUMAN
θ value	θ > 10 (rank : 52)	NC score	0.119620 (rank : 15)
Query Neighborhood Hits	32	Target Neighborhood Hits	82	Shared Neighborhood Hits	19
SwissProt Accessions	P15529, Q15429, Q53GV9, Q5HY94, Q5VWS6, Q5VWS7, Q5VWS8, Q5VWS9, Q5VWT0, Q5VWT1, Q5VWT2, Q6N0A1, Q7Z3R5, Q9NNW2, Q9NNW3, Q9NNW4	Gene names	CD46, MCP
Domain Architecture
Description	Membrane cofactor protein precursor (Trophoblast leukocyte common antigen) (TLX) (CD46 antigen).

MCP_MOUSE
θ value	θ > 10 (rank : 53)	NC score	0.119048 (rank : 16)
Query Neighborhood Hits	32	Target Neighborhood Hits	79	Shared Neighborhood Hits	19
SwissProt Accessions	O88174, Q9R0R9	Gene names	Cd46, Mcp
Domain Architecture	No domain graphic available
Description	Membrane cofactor protein precursor (CD46 antigen).

PAP2_HUMAN
θ value	θ > 10 (rank : 54)	NC score	0.064146 (rank : 42)
Query Neighborhood Hits	32	Target Neighborhood Hits	106	Shared Neighborhood Hits	19
SwissProt Accessions	Q9BXP8, Q96PH7, Q96PH8, Q9H4C9	Gene names	PAPPA2
Domain Architecture	No domain graphic available
Description	Pappalysin-2 precursor (EC 3.4.24.-) (Pregnancy-associated plasma protein-A2) (PAPP-A2) (Pregnancy-associated plasma protein-E1) (PAPP- E).

PAPPA_HUMAN
θ value	θ > 10 (rank : 55)	NC score	0.065270 (rank : 41)
Query Neighborhood Hits	32	Target Neighborhood Hits	161	Shared Neighborhood Hits	18
SwissProt Accessions	Q13219, Q08371, Q68G52, Q9UDK7	Gene names	PAPPA
Domain Architecture
Description	Pappalysin-1 precursor (EC 3.4.24.79) (Pregnancy-associated plasma protein-A) (PAPP-A) (Insulin-like growth factor-dependent IGF-binding protein 4 protease) (IGF-dependent IGFBP-4 protease) (IGFBP-4ase).

PAPPA_MOUSE
θ value	θ > 10 (rank : 56)	NC score	0.063608 (rank : 43)
Query Neighborhood Hits	32	Target Neighborhood Hits	153	Shared Neighborhood Hits	18
SwissProt Accessions	Q8R4K8, Q80VW3, Q80YY1, Q8K423, Q8R4K7, Q9ES06, Q9JK57	Gene names	Pappa
Domain Architecture	No domain graphic available
Description	Pappalysin-1 precursor (EC 3.4.24.79) (Pregnancy-associated plasma protein-A) (PAPP-A) (Insulin-like growth factor-dependent IGF-binding protein 4 protease) (IGF-dependent IGFBP-4 protease) (IGFBP-4ase).

SEZ6L_HUMAN
θ value	θ > 10 (rank : 57)	NC score	0.089057 (rank : 30)
Query Neighborhood Hits	32	Target Neighborhood Hits	289	Shared Neighborhood Hits	19
SwissProt Accessions	Q9BYH1, O95917, Q5THY5, Q6IBZ4, Q6UXD4, Q9NUI3, Q9NUI4, Q9NUI5, Q9Y2E1, Q9Y3J6	Gene names	SEZ6L, KIAA0927
Domain Architecture
Description	Seizure 6-like protein precursor.

SRPX_HUMAN
θ value	θ > 10 (rank : 58)	NC score	0.067757 (rank : 40)
Query Neighborhood Hits	32	Target Neighborhood Hits	69	Shared Neighborhood Hits	16
SwissProt Accessions	P78539, Q99652, Q99913	Gene names	SRPX, ETX1
Domain Architecture
Description	Sushi repeat-containing protein SRPX precursor.

SRPX_MOUSE
θ value	θ > 10 (rank : 59)	NC score	0.071918 (rank : 38)
Query Neighborhood Hits	32	Target Neighborhood Hits	75	Shared Neighborhood Hits	16
SwissProt Accessions	Q9R0M3, Q9R0M2	Gene names	Srpx
Domain Architecture	No domain graphic available
Description	Sushi-repeat-containing protein SRPX precursor (DRS protein).

SUSD2_HUMAN
θ value	θ > 10 (rank : 60)	NC score	0.050867 (rank : 48)
Query Neighborhood Hits	32	Target Neighborhood Hits	99	Shared Neighborhood Hits	20
SwissProt Accessions	Q9UGT4, Q9H5Y6	Gene names	SUSD2
Domain Architecture	No domain graphic available
Description	Sushi domain-containing protein 2 precursor.

SUSD2_MOUSE
θ value	θ > 10 (rank : 61)	NC score	0.056718 (rank : 44)
Query Neighborhood Hits	32	Target Neighborhood Hits	104	Shared Neighborhood Hits	20
SwissProt Accessions	Q9DBX3, Q8BY19, Q8BYN0, Q8BYZ3, Q8BYZ9, Q8BZQ4, Q8C179	Gene names	Susd2
Domain Architecture	No domain graphic available
Description	Sushi domain-containing protein 2 precursor.

SUSD4_HUMAN
θ value	θ > 10 (rank : 62)	NC score	0.101777 (rank : 23)
Query Neighborhood Hits	32	Target Neighborhood Hits	88	Shared Neighborhood Hits	18
SwissProt Accessions	Q5VX71, Q6UX62, Q9BSR0, Q9NWG0	Gene names	SUSD4
Domain Architecture	No domain graphic available
Description	Sushi domain-containing protein 4 precursor.

Hits sorted by NC score

IL2RA_HUMAN
NC score	0.999962 (rank : 1)	θ value	1.51632e-156 (rank : 1)
Query Neighborhood Hits	32	Target Neighborhood Hits	32	Shared Neighborhood Hits	32
SwissProt Accessions	P01589	Gene names	IL2RA
Domain Architecture
Description	Interleukin-2 receptor alpha chain precursor (IL-2 receptor alpha subunit) (IL-2-RA) (IL2-RA) (p55) (TAC antigen) (CD25 antigen).

IL2RA_MOUSE
NC score	0.950826 (rank : 2)	θ value	5.32145e-85 (rank : 2)
Query Neighborhood Hits	32	Target Neighborhood Hits	21	Shared Neighborhood Hits	9
SwissProt Accessions	P01590, Q61731	Gene names	Il2ra, Il2r
Domain Architecture
Description	Interleukin-2 receptor alpha chain precursor (IL-2 receptor alpha subunit) (IL-2-RA) (IL2-RA) (p55) (CD25 antigen).

DAF2_MOUSE
NC score	0.169526 (rank : 3)	θ value	0.125558 (rank : 6)
Query Neighborhood Hits	32	Target Neighborhood Hits	114	Shared Neighborhood Hits	22
SwissProt Accessions	Q61476	Gene names	Cd55b, Daf2
Domain Architecture
Description	Complement decay-accelerating factor transmembrane isoform precursor (DAF-TM) (CD55 antigen).

DAF1_MOUSE
NC score	0.166934 (rank : 4)	θ value	0.125558 (rank : 5)
Query Neighborhood Hits	32	Target Neighborhood Hits	204	Shared Neighborhood Hits	23
SwissProt Accessions	Q61475, P97732, Q61397	Gene names	Cd55a, Daf1
Domain Architecture
Description	Complement decay-accelerating factor, GPI-anchored precursor (DAF-GPI) (CD55 antigen).

CR2_MOUSE
NC score	0.166772 (rank : 5)	θ value	0.00869519 (rank : 3)
Query Neighborhood Hits	32	Target Neighborhood Hits	101	Shared Neighborhood Hits	20
SwissProt Accessions	P19070	Gene names	Cr2
Domain Architecture
Description	Complement receptor type 2 precursor (Cr2) (Complement C3d receptor) (CD21 antigen).

DAF_HUMAN
NC score	0.163117 (rank : 6)	θ value	0.279714 (rank : 8)
Query Neighborhood Hits	32	Target Neighborhood Hits	97	Shared Neighborhood Hits	20
SwissProt Accessions	P08174, P09679, P78361	Gene names	CD55, CR, DAF
Domain Architecture
Description	Complement decay-accelerating factor precursor (CD55 antigen).

C4BP_MOUSE
NC score	0.161163 (rank : 7)	θ value	0.163984 (rank : 7)
Query Neighborhood Hits	32	Target Neighborhood Hits	91	Shared Neighborhood Hits	21
SwissProt Accessions	P08607	Gene names	C4bpa, C4bp
Domain Architecture
Description	C4b-binding protein precursor (C4bp).

CR2_HUMAN
NC score	0.160477 (rank : 8)	θ value	0.0736092 (rank : 4)
Query Neighborhood Hits	32	Target Neighborhood Hits	89	Shared Neighborhood Hits	21
SwissProt Accessions	P20023, Q13866, Q14212	Gene names	CR2, C3DR
Domain Architecture
Description	Complement receptor type 2 precursor (Cr2) (Complement C3d receptor) (Epstein-Barr virus receptor) (EBV receptor) (CD21 antigen).

CR1_HUMAN
NC score	0.157306 (rank : 9)	θ value	0.813845 (rank : 11)
Query Neighborhood Hits	32	Target Neighborhood Hits	108	Shared Neighborhood Hits	22
SwissProt Accessions	P17927, Q16745, Q9UQV2	Gene names	CR1, C3BR
Domain Architecture
Description	Complement receptor type 1 precursor (C3b/C4b receptor) (CD35 antigen).

CRRY_MOUSE
NC score	0.155551 (rank : 10)	θ value	0.813845 (rank : 12)
Query Neighborhood Hits	32	Target Neighborhood Hits	84	Shared Neighborhood Hits	20
SwissProt Accessions	Q64735, Q3TV30, Q58E68, Q61447, Q61449, Q8CF59, Q8K328	Gene names	Crry, Cry
Domain Architecture	No domain graphic available
Description	Complement regulatory protein Crry precursor (Protein p65).

ZP3R_MOUSE
NC score	0.153039 (rank : 11)	θ value	0.47712 (rank : 9)
Query Neighborhood Hits	32	Target Neighborhood Hits	81	Shared Neighborhood Hits	20
SwissProt Accessions	Q60736	Gene names	Zp3r, Sp56
Domain Architecture
Description	Zona pellucida sperm-binding protein 3 receptor precursor (Sperm fertilization protein 56) (sp56).

CFAH_HUMAN
NC score	0.139987 (rank : 12)	θ value	0.62314 (rank : 10)
Query Neighborhood Hits	32	Target Neighborhood Hits	101	Shared Neighborhood Hits	21
SwissProt Accessions	P08603, P78435, Q14570, Q38G77, Q5TFM3, Q8N708, Q9NU86	Gene names	CFH, HF, HF1
Domain Architecture
Description	Complement factor H precursor (H factor 1).

CFAH_MOUSE
NC score	0.137328 (rank : 13)	θ value	1.38821 (rank : 13)
Query Neighborhood Hits	32	Target Neighborhood Hits	112	Shared Neighborhood Hits	21
SwissProt Accessions	P06909	Gene names	Cfh, Hf1
Domain Architecture
Description	Complement factor H precursor (Protein beta-1-H).

C4BP_HUMAN
NC score	0.135125 (rank : 14)	θ value	θ > 10 (rank : 36)
Query Neighborhood Hits	32	Target Neighborhood Hits	92	Shared Neighborhood Hits	19
SwissProt Accessions	P04003	Gene names	C4BPA, C4BP
Domain Architecture
Description	C4b-binding protein alpha chain precursor (C4bp) (Proline-rich protein) (PRP).

MCP_HUMAN
NC score	0.119620 (rank : 15)	θ value	θ > 10 (rank : 52)
Query Neighborhood Hits	32	Target Neighborhood Hits	82	Shared Neighborhood Hits	19
SwissProt Accessions	P15529, Q15429, Q53GV9, Q5HY94, Q5VWS6, Q5VWS7, Q5VWS8, Q5VWS9, Q5VWT0, Q5VWT1, Q5VWT2, Q6N0A1, Q7Z3R5, Q9NNW2, Q9NNW3, Q9NNW4	Gene names	CD46, MCP
Domain Architecture
Description	Membrane cofactor protein precursor (Trophoblast leukocyte common antigen) (TLX) (CD46 antigen).

MCP_MOUSE
NC score	0.119048 (rank : 16)	θ value	θ > 10 (rank : 53)
Query Neighborhood Hits	32	Target Neighborhood Hits	79	Shared Neighborhood Hits	19
SwissProt Accessions	O88174, Q9R0R9	Gene names	Cd46, Mcp
Domain Architecture	No domain graphic available
Description	Membrane cofactor protein precursor (CD46 antigen).

SUSD4_MOUSE
NC score	0.114630 (rank : 17)	θ value	2.36792 (rank : 19)
Query Neighborhood Hits	32	Target Neighborhood Hits	122	Shared Neighborhood Hits	19
SwissProt Accessions	Q8BH32, Q8VC43	Gene names	Susd4
Domain Architecture	No domain graphic available
Description	Sushi domain-containing protein 4 precursor.

CSMD1_HUMAN
NC score	0.104853 (rank : 18)	θ value	1.38821 (rank : 14)
Query Neighborhood Hits	32	Target Neighborhood Hits	176	Shared Neighborhood Hits	21
SwissProt Accessions	Q96PZ7, Q96QU9, Q96RM4	Gene names	CSMD1, KIAA1890
Domain Architecture
Description	CUB and sushi domain-containing protein 1 precursor (CUB and sushi multiple domains protein 1).

APOH_MOUSE
NC score	0.104196 (rank : 19)	θ value	θ > 10 (rank : 34)
Query Neighborhood Hits	32	Target Neighborhood Hits	74	Shared Neighborhood Hits	18
SwissProt Accessions	Q01339	Gene names	Apoh, B2gp1
Domain Architecture
Description	Beta-2-glycoprotein 1 precursor (Beta-2-glycoprotein I) (Apolipoprotein H) (Apo-H) (B2GPI) (Beta(2)GPI) (Activated protein C- binding protein) (APC inhibitor).

APOH_HUMAN
NC score	0.102151 (rank : 20)	θ value	θ > 10 (rank : 33)
Query Neighborhood Hits	32	Target Neighborhood Hits	75	Shared Neighborhood Hits	18
SwissProt Accessions	P02749, Q9UCN7	Gene names	APOH, B2G1
Domain Architecture
Description	Beta-2-glycoprotein 1 precursor (Beta-2-glycoprotein I) (Apolipoprotein H) (Apo-H) (B2GPI) (Beta(2)GPI) (Activated protein C- binding protein) (APC inhibitor) (Anticardiolipin cofactor).

F13B_HUMAN
NC score	0.102126 (rank : 21)	θ value	θ > 10 (rank : 41)
Query Neighborhood Hits	32	Target Neighborhood Hits	84	Shared Neighborhood Hits	17
SwissProt Accessions	P05160	Gene names	F13B
Domain Architecture
Description	Coagulation factor XIII B chain precursor (Protein-glutamine gamma- glutamyltransferase B chain) (Transglutaminase B chain) (Fibrin- stabilizing factor B subunit).

C4BB_HUMAN
NC score	0.102111 (rank : 22)	θ value	θ > 10 (rank : 35)
Query Neighborhood Hits	32	Target Neighborhood Hits	77	Shared Neighborhood Hits	18
SwissProt Accessions	P20851	Gene names	C4BPB
Domain Architecture
Description	C4b-binding protein beta chain precursor.

SUSD4_HUMAN
NC score	0.101777 (rank : 23)	θ value	θ > 10 (rank : 62)
Query Neighborhood Hits	32	Target Neighborhood Hits	88	Shared Neighborhood Hits	18
SwissProt Accessions	Q5VX71, Q6UX62, Q9BSR0, Q9NWG0	Gene names	SUSD4
Domain Architecture	No domain graphic available
Description	Sushi domain-containing protein 4 precursor.

CSMD1_MOUSE
NC score	0.101656 (rank : 24)	θ value	6.88961 (rank : 24)
Query Neighborhood Hits	32	Target Neighborhood Hits	193	Shared Neighborhood Hits	22
SwissProt Accessions	Q923L3, Q8BUV1, Q8BYQ3	Gene names	Csmd1
Domain Architecture
Description	CUB and sushi domain-containing protein 1 precursor (CUB and sushi multiple domains protein 1).

F13B_MOUSE
NC score	0.100566 (rank : 25)	θ value	θ > 10 (rank : 42)
Query Neighborhood Hits	32	Target Neighborhood Hits	93	Shared Neighborhood Hits	17
SwissProt Accessions	Q07968	Gene names	F13b, Cf13b
Domain Architecture
Description	Coagulation factor XIII B chain precursor (Protein-glutamine gamma- glutamyltransferase B chain) (Transglutaminase B chain).

FHR5_HUMAN
NC score	0.099255 (rank : 26)	θ value	θ > 10 (rank : 47)
Query Neighborhood Hits	32	Target Neighborhood Hits	77	Shared Neighborhood Hits	19
SwissProt Accessions	Q9BXR6	Gene names	CFHL5, FHR5
Domain Architecture
Description	Complement factor H-related protein 5 precursor (FHR-5).

FHR1_HUMAN
NC score	0.099085 (rank : 27)	θ value	θ > 10 (rank : 43)
Query Neighborhood Hits	32	Target Neighborhood Hits	80	Shared Neighborhood Hits	20
SwissProt Accessions	Q03591, Q9UJ17	Gene names	CFHL1, CFHL, FHR1, HFL1
Domain Architecture
Description	Complement factor H-related protein 1 precursor (FHR-1) (H factor-like protein 1) (H-factor-like 1) (H36).

CSMD3_HUMAN
NC score	0.098832 (rank : 28)	θ value	8.99809 (rank : 27)
Query Neighborhood Hits	32	Target Neighborhood Hits	199	Shared Neighborhood Hits	21
SwissProt Accessions	Q7Z407, Q96PZ3	Gene names	CSMD3, KIAA1894
Domain Architecture
Description	CUB and sushi domain-containing protein 3 precursor (CUB and sushi multiple domains protein 3).

CSMD2_HUMAN
NC score	0.096457 (rank : 29)	θ value	6.88961 (rank : 25)
Query Neighborhood Hits	32	Target Neighborhood Hits	188	Shared Neighborhood Hits	21
SwissProt Accessions	Q7Z408, Q5VT59, Q8N963, Q96Q03, Q9H4V7, Q9H4V8, Q9H4V9, Q9H4W0, Q9H4W1, Q9H4W2, Q9H4W3, Q9H4W4, Q9HCY5, Q9HCY6, Q9HCY7	Gene names	CSMD2, KIAA1884
Domain Architecture
Description	CUB and sushi domain-containing protein 2 (CUB and sushi multiple domains protein 2).

SEZ6L_HUMAN
NC score	0.089057 (rank : 30)	θ value	θ > 10 (rank : 57)
Query Neighborhood Hits	32	Target Neighborhood Hits	289	Shared Neighborhood Hits	19
SwissProt Accessions	Q9BYH1, O95917, Q5THY5, Q6IBZ4, Q6UXD4, Q9NUI3, Q9NUI4, Q9NUI5, Q9Y2E1, Q9Y3J6	Gene names	SEZ6L, KIAA0927
Domain Architecture
Description	Seizure 6-like protein precursor.

FHR4_HUMAN
NC score	0.087695 (rank : 31)	θ value	θ > 10 (rank : 46)
Query Neighborhood Hits	32	Target Neighborhood Hits	75	Shared Neighborhood Hits	19
SwissProt Accessions	Q92496, Q9UJY6	Gene names	CFHL4, FHR4
Domain Architecture
Description	Complement factor H-related protein 4 precursor (FHR-4).

FHR3_HUMAN
NC score	0.086172 (rank : 32)	θ value	θ > 10 (rank : 45)
Query Neighborhood Hits	32	Target Neighborhood Hits	74	Shared Neighborhood Hits	19
SwissProt Accessions	Q02985, Q9UJ16	Gene names	CFHL3, FHR3
Domain Architecture
Description	Complement factor H-related protein 3 precursor (FHR-3) (H factor-like protein 3) (DOWN16).

FHR2_HUMAN
NC score	0.084797 (rank : 33)	θ value	θ > 10 (rank : 44)
Query Neighborhood Hits	32	Target Neighborhood Hits	63	Shared Neighborhood Hits	19
SwissProt Accessions	P36980, Q14310	Gene names	CFHL2, FHR2, HFL3
Domain Architecture
Description	Complement factor H-related protein 2 precursor (FHR-2) (H factor-like protein 2) (H factor-like 3) (DDESK59).

LYAM3_HUMAN
NC score	0.084756 (rank : 34)	θ value	θ > 10 (rank : 50)
Query Neighborhood Hits	32	Target Neighborhood Hits	378	Shared Neighborhood Hits	19
SwissProt Accessions	P16109, Q8IVD1	Gene names	SELP, GMRP
Domain Architecture
Description	P-selectin precursor (Granule membrane protein 140) (GMP-140) (PADGEM) (Leukocyte-endothelial cell adhesion molecule 3) (LECAM3) (CD62P antigen).

LYAM3_MOUSE
NC score	0.083929 (rank : 35)	θ value	θ > 10 (rank : 51)
Query Neighborhood Hits	32	Target Neighborhood Hits	390	Shared Neighborhood Hits	19
SwissProt Accessions	Q01102	Gene names	Selp, Grmp
Domain Architecture
Description	P-selectin precursor (Granule membrane protein 140) (GMP-140) (PADGEM) (Leukocyte-endothelial cell adhesion molecule 3) (LECAM3) (CD62P antigen).

LYAM2_HUMAN
NC score	0.081491 (rank : 36)	θ value	θ > 10 (rank : 48)
Query Neighborhood Hits	32	Target Neighborhood Hits	394	Shared Neighborhood Hits	19
SwissProt Accessions	P16581, P16111	Gene names	SELE, ELAM1
Domain Architecture
Description	E-selectin precursor (Endothelial leukocyte adhesion molecule 1) (ELAM-1) (Leukocyte-endothelial cell adhesion molecule 2) (LECAM2) (CD62E antigen).

LYAM2_MOUSE
NC score	0.077039 (rank : 37)	θ value	θ > 10 (rank : 49)
Query Neighborhood Hits	32	Target Neighborhood Hits	420	Shared Neighborhood Hits	19
SwissProt Accessions	Q00690	Gene names	Sele, Elam-1
Domain Architecture
Description	E-selectin precursor (Endothelial leukocyte adhesion molecule 1) (ELAM-1) (Leukocyte-endothelial cell adhesion molecule 2) (LECAM2) (CD62E antigen).

SRPX_MOUSE
NC score	0.071918 (rank : 38)	θ value	θ > 10 (rank : 59)
Query Neighborhood Hits	32	Target Neighborhood Hits	75	Shared Neighborhood Hits	16
SwissProt Accessions	Q9R0M3, Q9R0M2	Gene names	Srpx
Domain Architecture	No domain graphic available
Description	Sushi-repeat-containing protein SRPX precursor (DRS protein).

I15RA_MOUSE
NC score	0.069539 (rank : 39)	θ value	2.36792 (rank : 17)
Query Neighborhood Hits	32	Target Neighborhood Hits	26	Shared Neighborhood Hits	10
SwissProt Accessions	Q60819, Q80Z90, Q80Z91, Q80Z92, Q8R5E4	Gene names	Il15ra
Domain Architecture	No domain graphic available
Description	Interleukin-15 receptor alpha chain precursor (IL-15R-alpha) (IL- 15RA).

SRPX_HUMAN
NC score	0.067757 (rank : 40)	θ value	θ > 10 (rank : 58)
Query Neighborhood Hits	32	Target Neighborhood Hits	69	Shared Neighborhood Hits	16
SwissProt Accessions	P78539, Q99652, Q99913	Gene names	SRPX, ETX1
Domain Architecture
Description	Sushi repeat-containing protein SRPX precursor.

PAPPA_HUMAN
NC score	0.065270 (rank : 41)	θ value	θ > 10 (rank : 55)
Query Neighborhood Hits	32	Target Neighborhood Hits	161	Shared Neighborhood Hits	18
SwissProt Accessions	Q13219, Q08371, Q68G52, Q9UDK7	Gene names	PAPPA
Domain Architecture
Description	Pappalysin-1 precursor (EC 3.4.24.79) (Pregnancy-associated plasma protein-A) (PAPP-A) (Insulin-like growth factor-dependent IGF-binding protein 4 protease) (IGF-dependent IGFBP-4 protease) (IGFBP-4ase).

PAP2_HUMAN
NC score	0.064146 (rank : 42)	θ value	θ > 10 (rank : 54)
Query Neighborhood Hits	32	Target Neighborhood Hits	106	Shared Neighborhood Hits	19
SwissProt Accessions	Q9BXP8, Q96PH7, Q96PH8, Q9H4C9	Gene names	PAPPA2
Domain Architecture	No domain graphic available
Description	Pappalysin-2 precursor (EC 3.4.24.-) (Pregnancy-associated plasma protein-A2) (PAPP-A2) (Pregnancy-associated plasma protein-E1) (PAPP- E).

PAPPA_MOUSE
NC score	0.063608 (rank : 43)	θ value	θ > 10 (rank : 56)
Query Neighborhood Hits	32	Target Neighborhood Hits	153	Shared Neighborhood Hits	18
SwissProt Accessions	Q8R4K8, Q80VW3, Q80YY1, Q8K423, Q8R4K7, Q9ES06, Q9JK57	Gene names	Pappa
Domain Architecture	No domain graphic available
Description	Pappalysin-1 precursor (EC 3.4.24.79) (Pregnancy-associated plasma protein-A) (PAPP-A) (Insulin-like growth factor-dependent IGF-binding protein 4 protease) (IGF-dependent IGFBP-4 protease) (IGFBP-4ase).

SUSD2_MOUSE
NC score	0.056718 (rank : 44)	θ value	θ > 10 (rank : 61)
Query Neighborhood Hits	32	Target Neighborhood Hits	104	Shared Neighborhood Hits	20
SwissProt Accessions	Q9DBX3, Q8BY19, Q8BYN0, Q8BYZ3, Q8BYZ9, Q8BZQ4, Q8C179	Gene names	Susd2
Domain Architecture	No domain graphic available
Description	Sushi domain-containing protein 2 precursor.

CO7_HUMAN
NC score	0.052290 (rank : 45)	θ value	θ > 10 (rank : 40)
Query Neighborhood Hits	32	Target Neighborhood Hits	278	Shared Neighborhood Hits	16
SwissProt Accessions	P10643, Q6P3T5, Q92489	Gene names	C7
Domain Architecture
Description	Complement component C7 precursor.

CO2_HUMAN
NC score	0.051779 (rank : 46)	θ value	θ > 10 (rank : 39)
Query Neighborhood Hits	32	Target Neighborhood Hits	258	Shared Neighborhood Hits	19
SwissProt Accessions	P06681, O19694, Q13904	Gene names	C2
Domain Architecture
Description	Complement C2 precursor (EC 3.4.21.43) (C3/C5 convertase) [Contains: Complement C2b fragment; Complement C2a fragment].

CFAB_MOUSE
NC score	0.050997 (rank : 47)	θ value	θ > 10 (rank : 38)
Query Neighborhood Hits	32	Target Neighborhood Hits	262	Shared Neighborhood Hits	19
SwissProt Accessions	P04186	Gene names	Cfb, Bf, H2-Bf
Domain Architecture
Description	Complement factor B precursor (EC 3.4.21.47) (C3/C5 convertase) [Contains: Complement factor B Ba fragment; Complement factor B Bb fragment].

SUSD2_HUMAN
NC score	0.050867 (rank : 48)	θ value	θ > 10 (rank : 60)
Query Neighborhood Hits	32	Target Neighborhood Hits	99	Shared Neighborhood Hits	20
SwissProt Accessions	Q9UGT4, Q9H5Y6	Gene names	SUSD2
Domain Architecture	No domain graphic available
Description	Sushi domain-containing protein 2 precursor.

CFAB_HUMAN
NC score	0.050100 (rank : 49)	θ value	θ > 10 (rank : 37)
Query Neighborhood Hits	32	Target Neighborhood Hits	251	Shared Neighborhood Hits	19
SwissProt Accessions	P00751, O15006, Q29944, Q96HX6, Q9BTF5, Q9BX92	Gene names	CFB, BF
Domain Architecture
Description	Complement factor B precursor (EC 3.4.21.47) (C3/C5 convertase) (Properdin factor B) (Glycine-rich beta glycoprotein) (GBG) (PBF2) [Contains: Complement factor B Ba fragment; Complement factor B Bb fragment].

PGCA_HUMAN
NC score	0.034291 (rank : 50)	θ value	4.03905 (rank : 23)
Query Neighborhood Hits	32	Target Neighborhood Hits	821	Shared Neighborhood Hits	19
SwissProt Accessions	P16112, Q13650, Q9UCP4, Q9UCP5, Q9UDE0	Gene names	AGC1, CSPG1
Domain Architecture
Description	Aggrecan core protein precursor (Cartilage-specific proteoglycan core protein) (CSPCP) (Chondroitin sulfate proteoglycan core protein 1) [Contains: Aggrecan core protein 2].

CS1B_MOUSE
NC score	0.033735 (rank : 51)	θ value	1.81305 (rank : 15)
Query Neighborhood Hits	32	Target Neighborhood Hits	361	Shared Neighborhood Hits	20
SwissProt Accessions	Q8CFG8	Gene names	C1sb, C1s
Domain Architecture	No domain graphic available
Description	Complement C1s-B subcomponent precursor (EC 3.4.21.42) (C1 esterase) [Contains: Complement C1s-B subcomponent heavy chain; Complement C1s-B subcomponent light chain].

CS1A_MOUSE
NC score	0.033051 (rank : 52)	θ value	3.0926 (rank : 20)
Query Neighborhood Hits	32	Target Neighborhood Hits	360	Shared Neighborhood Hits	20
SwissProt Accessions	Q8CG14, Q8BJC4, Q8CH28, Q8VBY4	Gene names	C1sa, C1s
Domain Architecture	No domain graphic available
Description	Complement C1s-A subcomponent precursor (EC 3.4.21.42) (C1 esterase) [Contains: Complement C1s-A subcomponent heavy chain; Complement C1s-A subcomponent light chain].

TNR6A_HUMAN
NC score	0.031371 (rank : 53)	θ value	3.0926 (rank : 21)
Query Neighborhood Hits	32	Target Neighborhood Hits	343	Shared Neighborhood Hits	2
SwissProt Accessions	Q8NDV7, O15408, Q658L5, Q6NVB5, Q8NEZ0, Q8TBT8, Q8TCR0, Q9NV59, Q9P268	Gene names	TNRC6A, CAGH26, KIAA1460, TNRC6
Domain Architecture	No domain graphic available
Description	Trinucleotide repeat-containing gene 6A protein (CAG repeat protein 26) (Glycine-tryptophan protein of 182 kDa) (GW182 autoantigen) (Protein GW1) (EMSY interactor protein).

NR1D2_HUMAN
NC score	0.022922 (rank : 54)	θ value	1.81305 (rank : 16)
Query Neighborhood Hits	32	Target Neighborhood Hits	115	Shared Neighborhood Hits	3
SwissProt Accessions	Q14995, O00402, Q86XD4	Gene names	NR1D2
Domain Architecture
Description	Orphan nuclear receptor NR1D2 (Rev-erb-beta) (EAR-1R) (Orphan nuclear hormone receptor BD73).

NR1D2_MOUSE
NC score	0.022075 (rank : 55)	θ value	2.36792 (rank : 18)
Query Neighborhood Hits	32	Target Neighborhood Hits	109	Shared Neighborhood Hits	3
SwissProt Accessions	Q60674, Q60646	Gene names	Nr1d2
Domain Architecture
Description	Orphan nuclear receptor NR1D2 (Rev-erb-beta) (Orphan nuclear receptor RVR).

VINC_HUMAN
NC score	0.021972 (rank : 56)	θ value	8.99809 (rank : 31)
Query Neighborhood Hits	32	Target Neighborhood Hits	145	Shared Neighborhood Hits	3
SwissProt Accessions	P18206, Q16450, Q5SWX2, Q7Z3B8, Q8IXU7	Gene names	VCL
Domain Architecture
Description	Vinculin (Metavinculin).

VINC_MOUSE
NC score	0.020490 (rank : 57)	θ value	8.99809 (rank : 32)
Query Neighborhood Hits	32	Target Neighborhood Hits	135	Shared Neighborhood Hits	3
SwissProt Accessions	Q64727, Q8BP32, Q8BS46, Q922C5, Q922D9	Gene names	Vcl
Domain Architecture
Description	Vinculin (Metavinculin).

BAP1_MOUSE
NC score	0.014780 (rank : 58)	θ value	8.99809 (rank : 26)
Query Neighborhood Hits	32	Target Neighborhood Hits	118	Shared Neighborhood Hits	2
SwissProt Accessions	Q99PU7, Q6ZQE6	Gene names	Bap1, Kiaa0272
Domain Architecture	No domain graphic available
Description	Ubiquitin carboxyl-terminal hydrolase BAP1 (EC 3.4.19.12) (BRCA1- associated protein 1) (Ubiquitin C-terminal hydrolase X4) (UCH-X4).

IC1_HUMAN
NC score	0.012843 (rank : 59)	θ value	4.03905 (rank : 22)
Query Neighborhood Hits	32	Target Neighborhood Hits	99	Shared Neighborhood Hits	3
SwissProt Accessions	P05155, Q547W3, Q59EI5, Q96FE0	Gene names	SERPING1, C1IN, C1NH
Domain Architecture
Description	Plasma protease C1 inhibitor precursor (C1 Inh) (C1Inh) (C1 esterase inhibitor) (C1-inhibiting factor).

PRG4_MOUSE
NC score	0.010318 (rank : 60)	θ value	8.99809 (rank : 29)
Query Neighborhood Hits	32	Target Neighborhood Hits	624	Shared Neighborhood Hits	4
SwissProt Accessions	Q9JM99, Q3UEL1, Q3V198	Gene names	Prg4, Msf, Szp
Domain Architecture	No domain graphic available
Description	Proteoglycan-4 precursor (Lubricin) (Megakaryocyte-stimulating factor) (Superficial zone proteoglycan) [Contains: Proteoglycan-4 C-terminal part].

EMR3_HUMAN
NC score	0.006994 (rank : 61)	θ value	8.99809 (rank : 28)
Query Neighborhood Hits	32	Target Neighborhood Hits	245	Shared Neighborhood Hits	4
SwissProt Accessions	Q9BY15	Gene names	EMR3
Domain Architecture
Description	EGF-like module-containing mucin-like hormone receptor-like 3 precursor (EGF-like module-containing mucin-like receptor EMR3).

SN1L2_MOUSE
NC score	0.000264 (rank : 62)	θ value	8.99809 (rank : 30)
Query Neighborhood Hits	32	Target Neighborhood Hits	944	Shared Neighborhood Hits	2
SwissProt Accessions	Q8CFH6	Gene names	Snf1lk2, Sik2
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase SNF1-like kinase 2 (EC 2.7.11.1) (Salt-inducible kinase 2).