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Network neighborhood for query Sequence : HSPB8_HUMAN

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HSPB8_HUMAN
SwissProt Accessions	Q9UJY1, Q6FIH3, Q9UKS3	Gene names	HSPB8, CRYAC, E2IG1, HSP22
Domain Architecture
Description	Heat-shock protein beta-8 (HspB8) (Alpha crystallin C chain) (Small stress protein-like protein HSP22) (E2-induced gene 1 protein) (Protein kinase H11).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

HSPB8_HUMAN
θ value	1.75921e-104 (rank : 1)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	25	Target Neighborhood Hits	25	Shared Neighborhood Hits	25
SwissProt Accessions	Q9UJY1, Q6FIH3, Q9UKS3	Gene names	HSPB8, CRYAC, E2IG1, HSP22
Domain Architecture
Description	Heat-shock protein beta-8 (HspB8) (Alpha crystallin C chain) (Small stress protein-like protein HSP22) (E2-induced gene 1 protein) (Protein kinase H11).

HSPB8_MOUSE
θ value	2.46047e-98 (rank : 2)	NC score	0.997955 (rank : 2)
Query Neighborhood Hits	25	Target Neighborhood Hits	34	Shared Neighborhood Hits	24
SwissProt Accessions	Q9JK92	Gene names	Hspb8, Cryac, Hsp22
Domain Architecture
Description	Heat-shock protein beta-8 (HspB8) (Alpha crystallin C chain) (Small stress protein-like protein HSP22).

HSPB1_MOUSE
θ value	2.77775e-25 (rank : 3)	NC score	0.886424 (rank : 3)
Query Neighborhood Hits	25	Target Neighborhood Hits	27	Shared Neighborhood Hits	20
SwissProt Accessions	P14602	Gene names	Hspb1, Hsp25, Hsp27
Domain Architecture
Description	Heat-shock protein beta-1 (HspB1) (Heat shock 27 kDa protein) (HSP 27) (Growth-related 25 kDa protein) (P25) (HSP25).

HSPB1_HUMAN
θ value	4.01107e-24 (rank : 4)	NC score	0.884172 (rank : 4)
Query Neighborhood Hits	25	Target Neighborhood Hits	25	Shared Neighborhood Hits	20
SwissProt Accessions	P04792, Q6FI47, Q9UC31	Gene names	HSPB1, HSP27
Domain Architecture
Description	Heat-shock protein beta-1 (HspB1) (Heat shock 27 kDa protein) (HSP 27) (Stress-responsive protein 27) (SRP27) (Estrogen-regulated 24 kDa protein) (28 kDa heat shock protein).

CRYAB_HUMAN
θ value	2.60593e-15 (rank : 5)	NC score	0.810776 (rank : 5)
Query Neighborhood Hits	25	Target Neighborhood Hits	18	Shared Neighborhood Hits	18
SwissProt Accessions	P02511, O43416	Gene names	CRYAB, CRYA2
Domain Architecture
Description	Alpha crystallin B chain (Alpha(B)-crystallin) (Rosenthal fiber component) (Heat-shock protein beta-5) (HspB5) (NY-REN-27 antigen).

CRYAB_MOUSE
θ value	7.58209e-15 (rank : 6)	NC score	0.809234 (rank : 6)
Query Neighborhood Hits	25	Target Neighborhood Hits	18	Shared Neighborhood Hits	18
SwissProt Accessions	P23927, Q64325	Gene names	Cryab, Crya2
Domain Architecture
Description	Alpha crystallin B chain (Alpha(B)-crystallin) (P23).

HSPB6_HUMAN
θ value	3.52202e-12 (rank : 7)	NC score	0.807520 (rank : 7)
Query Neighborhood Hits	25	Target Neighborhood Hits	19	Shared Neighborhood Hits	18
SwissProt Accessions	O14558, O14551, Q6NVI3, Q96MG9	Gene names	HSPB6
Domain Architecture
Description	Heat-shock protein beta-6 (HspB6) (Heat-shock 20 kDa-like protein p20).

HSPB6_MOUSE
θ value	1.02475e-11 (rank : 8)	NC score	0.803520 (rank : 8)
Query Neighborhood Hits	25	Target Neighborhood Hits	18	Shared Neighborhood Hits	18
SwissProt Accessions	Q5EBG6	Gene names	Hspb6
Domain Architecture	No domain graphic available
Description	Heat-shock protein beta-6 (HspB6).

CRYAA_HUMAN
θ value	6.64225e-11 (rank : 9)	NC score	0.776793 (rank : 9)
Query Neighborhood Hits	25	Target Neighborhood Hits	18	Shared Neighborhood Hits	18
SwissProt Accessions	P02489	Gene names	CRYAA, CRYA1, HSPB4
Domain Architecture
Description	Alpha crystallin A chain (Heat-shock protein beta-4) (HspB4) [Contains: Alpha crystallin A chain, short form].

CRYAA_MOUSE
θ value	1.9326e-10 (rank : 10)	NC score	0.766041 (rank : 12)
Query Neighborhood Hits	25	Target Neighborhood Hits	18	Shared Neighborhood Hits	18
SwissProt Accessions	P24622, P02490, P02496, P82532, Q61444, Q6LEL4	Gene names	Cryaa, Crya1
Domain Architecture
Description	Alpha crystallin A chain [Contains: Alpha crystallin A chain, short form].

HSPB2_HUMAN
θ value	9.59137e-10 (rank : 11)	NC score	0.769785 (rank : 10)
Query Neighborhood Hits	25	Target Neighborhood Hits	19	Shared Neighborhood Hits	18
SwissProt Accessions	Q16082, Q6I9U7	Gene names	HSPB2
Domain Architecture
Description	Heat-shock protein beta-2 (HspB2) (DMPK-binding protein) (MKBP).

HSPB2_MOUSE
θ value	9.59137e-10 (rank : 12)	NC score	0.767849 (rank : 11)
Query Neighborhood Hits	25	Target Neighborhood Hits	18	Shared Neighborhood Hits	18
SwissProt Accessions	Q99PR8, Q9CZC2	Gene names	Hspb2
Domain Architecture
Description	Heat-shock protein beta-2 (HspB2).

HSPB7_HUMAN
θ value	6.87365e-08 (rank : 13)	NC score	0.667983 (rank : 15)
Query Neighborhood Hits	25	Target Neighborhood Hits	18	Shared Neighborhood Hits	18
SwissProt Accessions	Q9UBY9, Q9NU17	Gene names	HSPB7, CVHSP
Domain Architecture
Description	Heat-shock protein beta-7 (HspB7) (Cardiovascular heat shock protein) (cvHsp).

HSPB3_HUMAN
θ value	1.99992e-07 (rank : 14)	NC score	0.702248 (rank : 14)
Query Neighborhood Hits	25	Target Neighborhood Hits	19	Shared Neighborhood Hits	17
SwissProt Accessions	Q12988	Gene names	HSPB3, HSPL27
Domain Architecture
Description	Heat-shock protein beta-3 (HspB3) (Heat shock 17 kDa protein).

HSPB3_MOUSE
θ value	4.45536e-07 (rank : 15)	NC score	0.703600 (rank : 13)
Query Neighborhood Hits	25	Target Neighborhood Hits	18	Shared Neighborhood Hits	17
SwissProt Accessions	Q9QZ57, Q569N3	Gene names	Hspb3
Domain Architecture
Description	Heat-shock protein beta-3 (HspB3).

HSPB7_MOUSE
θ value	4.45536e-07 (rank : 16)	NC score	0.654257 (rank : 16)
Query Neighborhood Hits	25	Target Neighborhood Hits	20	Shared Neighborhood Hits	18
SwissProt Accessions	P35385, Q8CDI0, Q9QUS2	Gene names	Hspb7, Cvhsp, Hsp25-2
Domain Architecture
Description	Heat-shock protein beta-7 (HspB7) (Cardiovascular heat shock protein) (cvHsp) (Heat shock protein 25 kDa 2) (Protein p19/6.8).

HSPB9_MOUSE
θ value	0.0113563 (rank : 17)	NC score	0.445412 (rank : 17)
Query Neighborhood Hits	25	Target Neighborhood Hits	19	Shared Neighborhood Hits	16
SwissProt Accessions	Q9DAM3	Gene names	Hspb9
Domain Architecture
Description	Heat-shock protein beta-9 (HspB9).

HSPB9_HUMAN
θ value	0.0736092 (rank : 18)	NC score	0.383757 (rank : 18)
Query Neighborhood Hits	25	Target Neighborhood Hits	17	Shared Neighborhood Hits	16
SwissProt Accessions	Q9BQS6, Q52LB4	Gene names	HSPB9
Domain Architecture
Description	Heat-shock protein beta-9 (HspB9).

ODFP_HUMAN
θ value	0.0961366 (rank : 19)	NC score	0.215289 (rank : 19)
Query Neighborhood Hits	25	Target Neighborhood Hits	32	Shared Neighborhood Hits	9
SwissProt Accessions	Q14990	Gene names	ODF1, ODFP
Domain Architecture
Description	Outer dense fiber protein.

ODFP_MOUSE
θ value	0.0961366 (rank : 20)	NC score	0.208943 (rank : 20)
Query Neighborhood Hits	25	Target Neighborhood Hits	75	Shared Neighborhood Hits	9
SwissProt Accessions	Q61999	Gene names	Odf1, Odfp
Domain Architecture
Description	Outer dense fiber protein.

DOK7_HUMAN
θ value	0.813845 (rank : 21)	NC score	0.077887 (rank : 21)
Query Neighborhood Hits	25	Target Neighborhood Hits	51	Shared Neighborhood Hits	4
SwissProt Accessions	Q18PE1, Q6P6A6, Q86XG5, Q8N2J3, Q8NBC1	Gene names	DOK7, C4orf25
Domain Architecture	No domain graphic available
Description	Protein Dok-7 (Downstream of tyrosine kinase 7).

DOK7_MOUSE
θ value	0.813845 (rank : 22)	NC score	0.065747 (rank : 22)
Query Neighborhood Hits	25	Target Neighborhood Hits	169	Shared Neighborhood Hits	5
SwissProt Accessions	Q18PE0, Q3TCZ6, Q5FW70, Q8C8U7	Gene names	Dok7
Domain Architecture	No domain graphic available
Description	Protein Dok-7 (Downstream of tyrosine kinase 7).

SPEG_MOUSE
θ value	5.27518 (rank : 23)	NC score	0.000089 (rank : 25)
Query Neighborhood Hits	25	Target Neighborhood Hits	1959	Shared Neighborhood Hits	4
SwissProt Accessions	Q62407, Q3TPH8, Q6P5V1, Q80TF7, Q80ZN0, Q8BZF4, Q9EQJ5	Gene names	Speg, Apeg1, Kiaa1297
Domain Architecture
Description	Striated muscle-specific serine/threonine protein kinase (EC 2.7.11.1) (Aortic preferentially expressed protein 1) (APEG-1).

CLCN1_MOUSE
θ value	6.88961 (rank : 24)	NC score	0.007770 (rank : 24)
Query Neighborhood Hits	25	Target Neighborhood Hits	61	Shared Neighborhood Hits	2
SwissProt Accessions	Q64347	Gene names	Clcn1, Clc1
Domain Architecture
Description	Chloride channel protein, skeletal muscle (Chloride channel protein 1) (ClC-1).

SMRC1_HUMAN
θ value	8.99809 (rank : 25)	NC score	0.010631 (rank : 23)
Query Neighborhood Hits	25	Target Neighborhood Hits	375	Shared Neighborhood Hits	3
SwissProt Accessions	Q92922, Q6P172, Q8IWH2	Gene names	SMARCC1, BAF155
Domain Architecture	No domain graphic available
Description	SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily C member 1 (SWI/SNF complex 155 kDa subunit) (BRG1-associated factor 155).

Hits sorted by NC score

HSPB8_HUMAN
NC score	0.999962 (rank : 1)	θ value	1.75921e-104 (rank : 1)
Query Neighborhood Hits	25	Target Neighborhood Hits	25	Shared Neighborhood Hits	25
SwissProt Accessions	Q9UJY1, Q6FIH3, Q9UKS3	Gene names	HSPB8, CRYAC, E2IG1, HSP22
Domain Architecture
Description	Heat-shock protein beta-8 (HspB8) (Alpha crystallin C chain) (Small stress protein-like protein HSP22) (E2-induced gene 1 protein) (Protein kinase H11).

HSPB8_MOUSE
NC score	0.997955 (rank : 2)	θ value	2.46047e-98 (rank : 2)
Query Neighborhood Hits	25	Target Neighborhood Hits	34	Shared Neighborhood Hits	24
SwissProt Accessions	Q9JK92	Gene names	Hspb8, Cryac, Hsp22
Domain Architecture
Description	Heat-shock protein beta-8 (HspB8) (Alpha crystallin C chain) (Small stress protein-like protein HSP22).

HSPB1_MOUSE
NC score	0.886424 (rank : 3)	θ value	2.77775e-25 (rank : 3)
Query Neighborhood Hits	25	Target Neighborhood Hits	27	Shared Neighborhood Hits	20
SwissProt Accessions	P14602	Gene names	Hspb1, Hsp25, Hsp27
Domain Architecture
Description	Heat-shock protein beta-1 (HspB1) (Heat shock 27 kDa protein) (HSP 27) (Growth-related 25 kDa protein) (P25) (HSP25).

HSPB1_HUMAN
NC score	0.884172 (rank : 4)	θ value	4.01107e-24 (rank : 4)
Query Neighborhood Hits	25	Target Neighborhood Hits	25	Shared Neighborhood Hits	20
SwissProt Accessions	P04792, Q6FI47, Q9UC31	Gene names	HSPB1, HSP27
Domain Architecture
Description	Heat-shock protein beta-1 (HspB1) (Heat shock 27 kDa protein) (HSP 27) (Stress-responsive protein 27) (SRP27) (Estrogen-regulated 24 kDa protein) (28 kDa heat shock protein).

CRYAB_HUMAN
NC score	0.810776 (rank : 5)	θ value	2.60593e-15 (rank : 5)
Query Neighborhood Hits	25	Target Neighborhood Hits	18	Shared Neighborhood Hits	18
SwissProt Accessions	P02511, O43416	Gene names	CRYAB, CRYA2
Domain Architecture
Description	Alpha crystallin B chain (Alpha(B)-crystallin) (Rosenthal fiber component) (Heat-shock protein beta-5) (HspB5) (NY-REN-27 antigen).

CRYAB_MOUSE
NC score	0.809234 (rank : 6)	θ value	7.58209e-15 (rank : 6)
Query Neighborhood Hits	25	Target Neighborhood Hits	18	Shared Neighborhood Hits	18
SwissProt Accessions	P23927, Q64325	Gene names	Cryab, Crya2
Domain Architecture
Description	Alpha crystallin B chain (Alpha(B)-crystallin) (P23).

HSPB6_HUMAN
NC score	0.807520 (rank : 7)	θ value	3.52202e-12 (rank : 7)
Query Neighborhood Hits	25	Target Neighborhood Hits	19	Shared Neighborhood Hits	18
SwissProt Accessions	O14558, O14551, Q6NVI3, Q96MG9	Gene names	HSPB6
Domain Architecture
Description	Heat-shock protein beta-6 (HspB6) (Heat-shock 20 kDa-like protein p20).

HSPB6_MOUSE
NC score	0.803520 (rank : 8)	θ value	1.02475e-11 (rank : 8)
Query Neighborhood Hits	25	Target Neighborhood Hits	18	Shared Neighborhood Hits	18
SwissProt Accessions	Q5EBG6	Gene names	Hspb6
Domain Architecture	No domain graphic available
Description	Heat-shock protein beta-6 (HspB6).

CRYAA_HUMAN
NC score	0.776793 (rank : 9)	θ value	6.64225e-11 (rank : 9)
Query Neighborhood Hits	25	Target Neighborhood Hits	18	Shared Neighborhood Hits	18
SwissProt Accessions	P02489	Gene names	CRYAA, CRYA1, HSPB4
Domain Architecture
Description	Alpha crystallin A chain (Heat-shock protein beta-4) (HspB4) [Contains: Alpha crystallin A chain, short form].

HSPB2_HUMAN
NC score	0.769785 (rank : 10)	θ value	9.59137e-10 (rank : 11)
Query Neighborhood Hits	25	Target Neighborhood Hits	19	Shared Neighborhood Hits	18
SwissProt Accessions	Q16082, Q6I9U7	Gene names	HSPB2
Domain Architecture
Description	Heat-shock protein beta-2 (HspB2) (DMPK-binding protein) (MKBP).

HSPB2_MOUSE
NC score	0.767849 (rank : 11)	θ value	9.59137e-10 (rank : 12)
Query Neighborhood Hits	25	Target Neighborhood Hits	18	Shared Neighborhood Hits	18
SwissProt Accessions	Q99PR8, Q9CZC2	Gene names	Hspb2
Domain Architecture
Description	Heat-shock protein beta-2 (HspB2).

CRYAA_MOUSE
NC score	0.766041 (rank : 12)	θ value	1.9326e-10 (rank : 10)
Query Neighborhood Hits	25	Target Neighborhood Hits	18	Shared Neighborhood Hits	18
SwissProt Accessions	P24622, P02490, P02496, P82532, Q61444, Q6LEL4	Gene names	Cryaa, Crya1
Domain Architecture
Description	Alpha crystallin A chain [Contains: Alpha crystallin A chain, short form].

HSPB3_MOUSE
NC score	0.703600 (rank : 13)	θ value	4.45536e-07 (rank : 15)
Query Neighborhood Hits	25	Target Neighborhood Hits	18	Shared Neighborhood Hits	17
SwissProt Accessions	Q9QZ57, Q569N3	Gene names	Hspb3
Domain Architecture
Description	Heat-shock protein beta-3 (HspB3).

HSPB3_HUMAN
NC score	0.702248 (rank : 14)	θ value	1.99992e-07 (rank : 14)
Query Neighborhood Hits	25	Target Neighborhood Hits	19	Shared Neighborhood Hits	17
SwissProt Accessions	Q12988	Gene names	HSPB3, HSPL27
Domain Architecture
Description	Heat-shock protein beta-3 (HspB3) (Heat shock 17 kDa protein).

HSPB7_HUMAN
NC score	0.667983 (rank : 15)	θ value	6.87365e-08 (rank : 13)
Query Neighborhood Hits	25	Target Neighborhood Hits	18	Shared Neighborhood Hits	18
SwissProt Accessions	Q9UBY9, Q9NU17	Gene names	HSPB7, CVHSP
Domain Architecture
Description	Heat-shock protein beta-7 (HspB7) (Cardiovascular heat shock protein) (cvHsp).

HSPB7_MOUSE
NC score	0.654257 (rank : 16)	θ value	4.45536e-07 (rank : 16)
Query Neighborhood Hits	25	Target Neighborhood Hits	20	Shared Neighborhood Hits	18
SwissProt Accessions	P35385, Q8CDI0, Q9QUS2	Gene names	Hspb7, Cvhsp, Hsp25-2
Domain Architecture
Description	Heat-shock protein beta-7 (HspB7) (Cardiovascular heat shock protein) (cvHsp) (Heat shock protein 25 kDa 2) (Protein p19/6.8).

HSPB9_MOUSE
NC score	0.445412 (rank : 17)	θ value	0.0113563 (rank : 17)
Query Neighborhood Hits	25	Target Neighborhood Hits	19	Shared Neighborhood Hits	16
SwissProt Accessions	Q9DAM3	Gene names	Hspb9
Domain Architecture
Description	Heat-shock protein beta-9 (HspB9).

HSPB9_HUMAN
NC score	0.383757 (rank : 18)	θ value	0.0736092 (rank : 18)
Query Neighborhood Hits	25	Target Neighborhood Hits	17	Shared Neighborhood Hits	16
SwissProt Accessions	Q9BQS6, Q52LB4	Gene names	HSPB9
Domain Architecture
Description	Heat-shock protein beta-9 (HspB9).

ODFP_HUMAN
NC score	0.215289 (rank : 19)	θ value	0.0961366 (rank : 19)
Query Neighborhood Hits	25	Target Neighborhood Hits	32	Shared Neighborhood Hits	9
SwissProt Accessions	Q14990	Gene names	ODF1, ODFP
Domain Architecture
Description	Outer dense fiber protein.

ODFP_MOUSE
NC score	0.208943 (rank : 20)	θ value	0.0961366 (rank : 20)
Query Neighborhood Hits	25	Target Neighborhood Hits	75	Shared Neighborhood Hits	9
SwissProt Accessions	Q61999	Gene names	Odf1, Odfp
Domain Architecture
Description	Outer dense fiber protein.

DOK7_HUMAN
NC score	0.077887 (rank : 21)	θ value	0.813845 (rank : 21)
Query Neighborhood Hits	25	Target Neighborhood Hits	51	Shared Neighborhood Hits	4
SwissProt Accessions	Q18PE1, Q6P6A6, Q86XG5, Q8N2J3, Q8NBC1	Gene names	DOK7, C4orf25
Domain Architecture	No domain graphic available
Description	Protein Dok-7 (Downstream of tyrosine kinase 7).

DOK7_MOUSE
NC score	0.065747 (rank : 22)	θ value	0.813845 (rank : 22)
Query Neighborhood Hits	25	Target Neighborhood Hits	169	Shared Neighborhood Hits	5
SwissProt Accessions	Q18PE0, Q3TCZ6, Q5FW70, Q8C8U7	Gene names	Dok7
Domain Architecture	No domain graphic available
Description	Protein Dok-7 (Downstream of tyrosine kinase 7).

SMRC1_HUMAN
NC score	0.010631 (rank : 23)	θ value	8.99809 (rank : 25)
Query Neighborhood Hits	25	Target Neighborhood Hits	375	Shared Neighborhood Hits	3
SwissProt Accessions	Q92922, Q6P172, Q8IWH2	Gene names	SMARCC1, BAF155
Domain Architecture	No domain graphic available
Description	SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily C member 1 (SWI/SNF complex 155 kDa subunit) (BRG1-associated factor 155).

CLCN1_MOUSE
NC score	0.007770 (rank : 24)	θ value	6.88961 (rank : 24)
Query Neighborhood Hits	25	Target Neighborhood Hits	61	Shared Neighborhood Hits	2
SwissProt Accessions	Q64347	Gene names	Clcn1, Clc1
Domain Architecture
Description	Chloride channel protein, skeletal muscle (Chloride channel protein 1) (ClC-1).

SPEG_MOUSE
NC score	0.000089 (rank : 25)	θ value	5.27518 (rank : 23)
Query Neighborhood Hits	25	Target Neighborhood Hits	1959	Shared Neighborhood Hits	4
SwissProt Accessions	Q62407, Q3TPH8, Q6P5V1, Q80TF7, Q80ZN0, Q8BZF4, Q9EQJ5	Gene names	Speg, Apeg1, Kiaa1297
Domain Architecture
Description	Striated muscle-specific serine/threonine protein kinase (EC 2.7.11.1) (Aortic preferentially expressed protein 1) (APEG-1).