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Network neighborhood for query Sequence : HEM1_HUMAN

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HEM1_HUMAN
SwissProt Accessions	P13196	Gene names	ALAS1, ALASH
Domain Architecture
Description	5-aminolevulinate synthase, nonspecific, mitochondrial precursor (EC 2.3.1.37) (5-aminolevulinic acid synthase) (Delta-aminolevulinate synthase) (Delta-ALA synthetase) (ALAS-H).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

HEM0_HUMAN
θ value	0 (rank : 1)	NC score	0.989898 (rank : 4)
Query Neighborhood Hits	45	Target Neighborhood Hits	16	Shared Neighborhood Hits	10
SwissProt Accessions	P22557, Q13735	Gene names	ALAS2, ALASE, ASB
Domain Architecture
Description	5-aminolevulinate synthase, erythroid-specific, mitochondrial precursor (EC 2.3.1.37) (5-aminolevulinic acid synthase) (Delta- aminolevulinate synthase) (Delta-ALA synthetase) (ALAS-E).

HEM0_MOUSE
θ value	0 (rank : 2)	NC score	0.990139 (rank : 3)
Query Neighborhood Hits	45	Target Neighborhood Hits	12	Shared Neighborhood Hits	10
SwissProt Accessions	P08680, Q64452, Q9DCN0	Gene names	Alas2
Domain Architecture
Description	5-aminolevulinate synthase, erythroid-specific, mitochondrial precursor (EC 2.3.1.37) (5-aminolevulinic acid synthase) (Delta- aminolevulinate synthase) (Delta-ALA synthetase) (ALAS-E).

HEM1_HUMAN
θ value	0 (rank : 3)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	45	Target Neighborhood Hits	45	Shared Neighborhood Hits	45
SwissProt Accessions	P13196	Gene names	ALAS1, ALASH
Domain Architecture
Description	5-aminolevulinate synthase, nonspecific, mitochondrial precursor (EC 2.3.1.37) (5-aminolevulinic acid synthase) (Delta-aminolevulinate synthase) (Delta-ALA synthetase) (ALAS-H).

HEM1_MOUSE
θ value	0 (rank : 4)	NC score	0.990798 (rank : 2)
Query Neighborhood Hits	45	Target Neighborhood Hits	66	Shared Neighborhood Hits	17
SwissProt Accessions	Q8VC19, Q64453	Gene names	Alas1
Domain Architecture	No domain graphic available
Description	5-aminolevulinate synthase, nonspecific, mitochondrial precursor (EC 2.3.1.37) (5-aminolevulinic acid synthase) (Delta-aminolevulinate synthase) (Delta-ALA synthetase) (ALAS-H).

KBL_MOUSE
θ value	2.84797e-54 (rank : 5)	NC score	0.899196 (rank : 5)
Query Neighborhood Hits	45	Target Neighborhood Hits	12	Shared Neighborhood Hits	10
SwissProt Accessions	O88986	Gene names	Gcat, Kbl
Domain Architecture
Description	2-amino-3-ketobutyrate coenzyme A ligase, mitochondrial precursor (EC 2.3.1.29) (AKB ligase) (Glycine acetyltransferase).

KBL_HUMAN
θ value	1.04822e-48 (rank : 6)	NC score	0.895733 (rank : 6)
Query Neighborhood Hits	45	Target Neighborhood Hits	13	Shared Neighborhood Hits	10
SwissProt Accessions	O75600, Q96CA9	Gene names	GCAT, KBL
Domain Architecture
Description	2-amino-3-ketobutyrate coenzyme A ligase, mitochondrial precursor (EC 2.3.1.29) (AKB ligase) (Glycine acetyltransferase).

LCB2_MOUSE
θ value	1.08726e-37 (rank : 7)	NC score	0.818621 (rank : 7)
Query Neighborhood Hits	45	Target Neighborhood Hits	12	Shared Neighborhood Hits	10
SwissProt Accessions	P97363, P97356	Gene names	Sptlc2, Lcb2
Domain Architecture
Description	Serine palmitoyltransferase 2 (EC 2.3.1.50) (Long chain base biosynthesis protein 2) (LCB 2) (Serine-palmitoyl-CoA transferase 2) (SPT 2).

LCB2_HUMAN
θ value	4.568e-36 (rank : 8)	NC score	0.816389 (rank : 8)
Query Neighborhood Hits	45	Target Neighborhood Hits	12	Shared Neighborhood Hits	10
SwissProt Accessions	O15270, Q16685	Gene names	SPTLC2, KIAA0526, LCB2
Domain Architecture
Description	Serine palmitoyltransferase 2 (EC 2.3.1.50) (Long chain base biosynthesis protein 2) (LCB 2) (Serine-palmitoyl-CoA transferase 2) (SPT 2).

LCB1_MOUSE
θ value	8.08199e-25 (rank : 9)	NC score	0.780718 (rank : 9)
Query Neighborhood Hits	45	Target Neighborhood Hits	22	Shared Neighborhood Hits	10
SwissProt Accessions	O35704, O54813	Gene names	Sptlc1, Lcb1
Domain Architecture
Description	Serine palmitoyltransferase 1 (EC 2.3.1.50) (Long chain base biosynthesis protein 1) (LCB 1) (Serine-palmitoyl-CoA transferase 1) (SPT 1) (SPT1).

LCB1_HUMAN
θ value	4.01107e-24 (rank : 10)	NC score	0.778856 (rank : 10)
Query Neighborhood Hits	45	Target Neighborhood Hits	21	Shared Neighborhood Hits	10
SwissProt Accessions	O15269	Gene names	SPTLC1, LCB1
Domain Architecture
Description	Serine palmitoyltransferase 1 (EC 2.3.1.50) (Long chain base biosynthesis protein 1) (LCB 1) (Serine-palmitoyl-CoA transferase 1) (SPT 1) (SPT1).

MILK2_HUMAN
θ value	0.365318 (rank : 11)	NC score	0.018307 (rank : 14)
Query Neighborhood Hits	45	Target Neighborhood Hits	457	Shared Neighborhood Hits	6
SwissProt Accessions	Q8IY33, Q7RTP4, Q7Z655, Q8TEQ4, Q9H5F9	Gene names
Domain Architecture
Description	MICAL-like protein 2.

MLL2_HUMAN
θ value	0.62314 (rank : 12)	NC score	0.013751 (rank : 23)
Query Neighborhood Hits	45	Target Neighborhood Hits	1788	Shared Neighborhood Hits	15
SwissProt Accessions	O14686, O14687	Gene names	MLL2, ALR
Domain Architecture
Description	Myeloid/lymphoid or mixed-lineage leukemia protein 2 (ALL1-related protein).

CMTA2_MOUSE
θ value	1.81305 (rank : 13)	NC score	0.021138 (rank : 13)
Query Neighborhood Hits	45	Target Neighborhood Hits	216	Shared Neighborhood Hits	4
SwissProt Accessions	Q80Y50, Q3TFK0, Q5SX68, Q80TP1, Q8R0D9, Q8R2N5	Gene names	Camta2, Kiaa0909
Domain Architecture	No domain graphic available
Description	Calmodulin-binding transcription activator 2.

CN155_HUMAN
θ value	3.0926 (rank : 14)	NC score	0.015120 (rank : 22)
Query Neighborhood Hits	45	Target Neighborhood Hits	385	Shared Neighborhood Hits	7
SwissProt Accessions	Q5H9T9, Q5H9U7, Q86YI2, Q9H0J3	Gene names	C14orf155
Domain Architecture	No domain graphic available
Description	Protein C14orf155.

CNOT6_MOUSE
θ value	3.0926 (rank : 15)	NC score	0.012254 (rank : 24)
Query Neighborhood Hits	45	Target Neighborhood Hits	229	Shared Neighborhood Hits	3
SwissProt Accessions	Q8K3P5, Q5NCL3, Q80V15	Gene names	Cnot6, Ccr4, Kiaa1194
Domain Architecture
Description	CCR4-NOT transcription complex subunit 6 (EC 3.1.-.-) (Cytoplasmic deadenylase) (Carbon catabolite repressor protein 4 homolog) (CCR4 carbon catabolite repression 4-like).

ZC11A_MOUSE
θ value	3.0926 (rank : 16)	NC score	0.016533 (rank : 18)
Query Neighborhood Hits	45	Target Neighborhood Hits	216	Shared Neighborhood Hits	4
SwissProt Accessions	Q6NZF1, Q6NXW9, Q6PDR6, Q80TU7, Q8C5L5, Q99JN6	Gene names	Zc3h11a, Kiaa0663
Domain Architecture	No domain graphic available
Description	Zinc finger CCCH domain-containing protein 11A.

CAF1A_HUMAN
θ value	4.03905 (rank : 17)	NC score	0.008902 (rank : 30)
Query Neighborhood Hits	45	Target Neighborhood Hits	750	Shared Neighborhood Hits	5
SwissProt Accessions	Q13111, Q7Z7K3, Q9UJY8	Gene names	CHAF1A, CAF, CAF1P150
Domain Architecture	No domain graphic available
Description	Chromatin assembly factor 1 subunit A (CAF-1 subunit A) (Chromatin assembly factor I p150 subunit) (CAF-I 150 kDa subunit) (CAF-Ip150).

CHD6_HUMAN
θ value	4.03905 (rank : 18)	NC score	0.005908 (rank : 37)
Query Neighborhood Hits	45	Target Neighborhood Hits	342	Shared Neighborhood Hits	5
SwissProt Accessions	Q8TD26, Q5JYQ0, Q5TGZ9, Q5TH00, Q5TH01, Q8IZR2, Q8WTY0, Q9H4H6, Q9H6D4, Q9NTT7, Q9P2L1	Gene names	CHD6, CHD5, KIAA1335, RIGB
Domain Architecture
Description	Chromodomain-helicase-DNA-binding protein 6 (EC 3.6.1.-) (ATP- dependent helicase CHD6) (CHD-6) (Radiation-induced gene B protein).

CJ026_MOUSE
θ value	4.03905 (rank : 19)	NC score	0.015181 (rank : 21)
Query Neighborhood Hits	45	Target Neighborhood Hits	92	Shared Neighborhood Hits	2
SwissProt Accessions	Q8BGW2, Q3TF48, Q3U3M2, Q6PD43, Q8R0W8	Gene names	D19Wsu162e
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C10orf26 homolog.

REPS2_HUMAN
θ value	4.03905 (rank : 20)	NC score	0.012221 (rank : 25)
Query Neighborhood Hits	45	Target Neighborhood Hits	131	Shared Neighborhood Hits	4
SwissProt Accessions	Q8NFH8, O43428, Q8NFI5	Gene names	REPS2, POB1
Domain Architecture
Description	RalBP1-associated Eps domain-containing protein 2 (RalBP1-interacting protein 2) (Partner of RalBP1).

MRP_MOUSE
θ value	5.27518 (rank : 21)	NC score	0.017803 (rank : 15)
Query Neighborhood Hits	45	Target Neighborhood Hits	53	Shared Neighborhood Hits	2
SwissProt Accessions	P28667, Q3TEZ4, Q91W07	Gene names	Marcksl1, Mlp, Mrp
Domain Architecture	No domain graphic available
Description	MARCKS-related protein (MARCKS-like protein 1) (Macrophage myristoylated alanine-rich C kinase substrate) (Mac-MARCKS) (MacMARCKS) (Brain protein F52).

PCLO_HUMAN
θ value	5.27518 (rank : 22)	NC score	0.005338 (rank : 38)
Query Neighborhood Hits	45	Target Neighborhood Hits	2046	Shared Neighborhood Hits	21
SwissProt Accessions	Q9Y6V0, O43373, O60305, Q9BVC8, Q9UIV2, Q9Y6U9	Gene names	PCLO, ACZ, KIAA0559
Domain Architecture
Description	Protein piccolo (Aczonin).

PO6F2_HUMAN
θ value	5.27518 (rank : 23)	NC score	0.008257 (rank : 33)
Query Neighborhood Hits	45	Target Neighborhood Hits	618	Shared Neighborhood Hits	6
SwissProt Accessions	P78424, P78425, Q75ME8, Q86UM6, Q9UDS7	Gene names	POU6F2, RPF1
Domain Architecture
Description	POU domain, class 6, transcription factor 2 (Retina-derived POU-domain factor 1) (RPF-1).

RAE1D_MOUSE
θ value	5.27518 (rank : 24)	NC score	0.010419 (rank : 28)
Query Neighborhood Hits	45	Target Neighborhood Hits	17	Shared Neighborhood Hits	2
SwissProt Accessions	Q9JI58	Gene names	Raet1d
Domain Architecture
Description	Retinoic acid early inducible protein 1 delta precursor (RAE-1delta).

TAF6_HUMAN
θ value	5.27518 (rank : 25)	NC score	0.017514 (rank : 16)
Query Neighborhood Hits	45	Target Neighborhood Hits	127	Shared Neighborhood Hits	6
SwissProt Accessions	P49848	Gene names	TAF6, TAF2E, TAFII70
Domain Architecture
Description	Transcription initiation factor TFIID subunit 6 (Transcription initiation factor TFIID 70 kDa subunit) (TAF(II)70) (TAFII-70) (TAFII- 80) (TAFII80).

CNOT6_HUMAN
θ value	6.88961 (rank : 26)	NC score	0.010960 (rank : 27)
Query Neighborhood Hits	45	Target Neighborhood Hits	225	Shared Neighborhood Hits	3
SwissProt Accessions	Q9ULM6	Gene names	CNOT6, CCR4, KIAA1194
Domain Architecture
Description	CCR4-NOT transcription complex subunit 6 (EC 3.1.-.-) (Cytoplasmic deadenylase) (Carbon catabolite repressor protein 4 homolog) (CCR4 carbon catabolite repression 4-like).

ENAH_HUMAN
θ value	6.88961 (rank : 27)	NC score	0.008755 (rank : 31)
Query Neighborhood Hits	45	Target Neighborhood Hits	784	Shared Neighborhood Hits	8
SwissProt Accessions	Q8N8S7, Q502W5, Q5T5M7, Q5VTQ9, Q5VTR0, Q9NVF3, Q9UFB8	Gene names	ENAH, MENA
Domain Architecture
Description	Protein enabled homolog.

GLGB_HUMAN
θ value	6.88961 (rank : 28)	NC score	0.017317 (rank : 17)
Query Neighborhood Hits	45	Target Neighborhood Hits	10	Shared Neighborhood Hits	3
SwissProt Accessions	Q04446, Q96EN0	Gene names	GBE1
Domain Architecture
Description	1,4-alpha-glucan branching enzyme (EC 2.4.1.18) (Glycogen branching enzyme) (Brancher enzyme).

GZF1_HUMAN
θ value	6.88961 (rank : 29)	NC score	-0.001788 (rank : 45)
Query Neighborhood Hits	45	Target Neighborhood Hits	854	Shared Neighborhood Hits	3
SwissProt Accessions	Q9H116, Q96N08, Q9BQK9, Q9H117, Q9H6W6	Gene names	GZF1, ZBTB23, ZNF336
Domain Architecture
Description	GDNF-inducible zinc finger protein 1 (Zinc finger protein 336) (Zinc finger and BTB domain-containing protein 23).

PAR3L_HUMAN
θ value	6.88961 (rank : 30)	NC score	0.006053 (rank : 36)
Query Neighborhood Hits	45	Target Neighborhood Hits	297	Shared Neighborhood Hits	6
SwissProt Accessions	Q8TEW8, Q8IUC7, Q8IUC9, Q96DK9, Q96N09, Q96NX6, Q96NX7, Q96Q29	Gene names	PARD3B, ALS2CR19, PAR3B, PAR3L
Domain Architecture
Description	Partitioning-defective 3 homolog B (PAR3-beta) (Partitioning-defective 3-like protein) (PAR3-L protein) (Amyotrophic lateral sclerosis 2 chromosome region candidate gene 19 protein).

RERE_HUMAN
θ value	6.88961 (rank : 31)	NC score	0.008446 (rank : 32)
Query Neighborhood Hits	45	Target Neighborhood Hits	779	Shared Neighborhood Hits	9
SwissProt Accessions	Q9P2R6, O43393, O75046, O75359, Q5VXL9, Q6P6B9, Q9Y2W4	Gene names	RERE, ARG, ARP, ATN1L, KIAA0458
Domain Architecture	No domain graphic available
Description	Arginine-glutamic acid dipeptide repeats protein (Atrophin-1-like protein) (Atrophin-1-related protein).

APOA4_HUMAN
θ value	8.99809 (rank : 32)	NC score	0.004504 (rank : 41)
Query Neighborhood Hits	45	Target Neighborhood Hits	399	Shared Neighborhood Hits	3
SwissProt Accessions	P06727, Q6Q787	Gene names	APOA4
Domain Architecture
Description	Apolipoprotein A-IV precursor (Apo-AIV) (ApoA-IV).

ATE1_HUMAN
θ value	8.99809 (rank : 33)	NC score	0.025660 (rank : 12)
Query Neighborhood Hits	45	Target Neighborhood Hits	11	Shared Neighborhood Hits	3
SwissProt Accessions	O95260, O95261, Q8WW04	Gene names	ATE1
Domain Architecture
Description	Arginyl-tRNA--protein transferase 1 (EC 2.3.2.8) (R-transferase 1) (Arginyltransferase 1) (Arginine-tRNA--protein transferase 1).

CA103_HUMAN
θ value	8.99809 (rank : 34)	NC score	0.009578 (rank : 29)
Query Neighborhood Hits	45	Target Neighborhood Hits	82	Shared Neighborhood Hits	3
SwissProt Accessions	Q5T3J3, Q86XS4, Q8N3B6, Q96HT4, Q9NUM5, Q9NV32	Gene names	C1orf103, RIF1
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C1orf103 (Receptor-interacting factor 1).

CBP_MOUSE
θ value	8.99809 (rank : 35)	NC score	0.005009 (rank : 40)
Query Neighborhood Hits	45	Target Neighborhood Hits	1051	Shared Neighborhood Hits	11
SwissProt Accessions	P45481	Gene names	Crebbp, Cbp
Domain Architecture
Description	CREB-binding protein (EC 2.3.1.48).

DLGP2_MOUSE
θ value	8.99809 (rank : 36)	NC score	0.006312 (rank : 35)
Query Neighborhood Hits	45	Target Neighborhood Hits	49	Shared Neighborhood Hits	2
SwissProt Accessions	Q8BJ42, Q6XBF3	Gene names	Dlgap2, Dap2
Domain Architecture	No domain graphic available
Description	Disks large-associated protein 2 (DAP-2) (SAP90/PSD-95-associated protein 2) (SAPAP2) (PSD-95/SAP90-binding protein 2).

FGD1_HUMAN
θ value	8.99809 (rank : 37)	NC score	0.002757 (rank : 43)
Query Neighborhood Hits	45	Target Neighborhood Hits	367	Shared Neighborhood Hits	3
SwissProt Accessions	P98174, Q8N4D9	Gene names	FGD1, ZFYVE3
Domain Architecture
Description	FYVE, RhoGEF and PH domain-containing protein 1 (Faciogenital dysplasia 1 protein) (Zinc finger FYVE domain-containing protein 3) (Rho/Rac guanine nucleotide exchange factor FGD1) (Rho/Rac GEF).

PLXD1_HUMAN
θ value	8.99809 (rank : 38)	NC score	0.003648 (rank : 42)
Query Neighborhood Hits	45	Target Neighborhood Hits	89	Shared Neighborhood Hits	2
SwissProt Accessions	Q9Y4D7, Q6PJS9, Q8IZJ2, Q9BTQ2	Gene names	PLXND1, KIAA0620
Domain Architecture	No domain graphic available
Description	Plexin-D1 precursor.

PO121_HUMAN
θ value	8.99809 (rank : 39)	NC score	0.007190 (rank : 34)
Query Neighborhood Hits	45	Target Neighborhood Hits	344	Shared Neighborhood Hits	6
SwissProt Accessions	Q9Y2N3, O75115, Q9Y4S7	Gene names	POM121, KIAA0618, NUP121
Domain Architecture	No domain graphic available
Description	Nuclear envelope pore membrane protein POM 121 (Pore membrane protein of 121 kDa) (P145).

RERE_MOUSE
θ value	8.99809 (rank : 40)	NC score	0.015687 (rank : 19)
Query Neighborhood Hits	45	Target Neighborhood Hits	785	Shared Neighborhood Hits	8
SwissProt Accessions	Q80TZ9	Gene names	Rere, Atr2, Kiaa0458
Domain Architecture	No domain graphic available
Description	Arginine-glutamic acid dipeptide repeats protein (Atrophin-2).

RPGF2_HUMAN
θ value	8.99809 (rank : 41)	NC score	0.005192 (rank : 39)
Query Neighborhood Hits	45	Target Neighborhood Hits	242	Shared Neighborhood Hits	3
SwissProt Accessions	Q9Y4G8	Gene names	RAPGEF2, KIAA0313, NRAPGEP, PDZGEF1
Domain Architecture	No domain graphic available
Description	Rap guanine nucleotide exchange factor 2 (Neural RAP guanine nucleotide exchange protein) (nRap GEP) (PDZ domain-containing guanine nucleotide exchange factor 1) (PDZ-GEF1) (RA-GEF).

STK10_HUMAN
θ value	8.99809 (rank : 42)	NC score	-0.002113 (rank : 46)
Query Neighborhood Hits	45	Target Neighborhood Hits	1921	Shared Neighborhood Hits	11
SwissProt Accessions	O94804, Q9UIW4	Gene names	STK10, LOK
Domain Architecture
Description	Serine/threonine-protein kinase 10 (EC 2.7.11.1) (Lymphocyte-oriented kinase).

T2EB_MOUSE
θ value	8.99809 (rank : 43)	NC score	0.011041 (rank : 26)
Query Neighborhood Hits	45	Target Neighborhood Hits	11	Shared Neighborhood Hits	2
SwissProt Accessions	Q9D902, Q3U5Y7, Q8BTZ2, Q8VE14	Gene names	Gtf2e2
Domain Architecture	No domain graphic available
Description	Transcription initiation factor IIE subunit beta (TFIIE-beta).

TAF6_MOUSE
θ value	8.99809 (rank : 44)	NC score	0.015400 (rank : 20)
Query Neighborhood Hits	45	Target Neighborhood Hits	110	Shared Neighborhood Hits	5
SwissProt Accessions	Q62311	Gene names	Taf6, Taf2e
Domain Architecture
Description	Transcription initiation factor TFIID subunit 6 (Transcription initiation factor TFIID 70 kDa subunit) (TAF(II)70) (TAFII-70) (TAFII- 80) (TAFII80) (p80).

ZEP1_MOUSE
θ value	8.99809 (rank : 45)	NC score	0.000917 (rank : 44)
Query Neighborhood Hits	45	Target Neighborhood Hits	1063	Shared Neighborhood Hits	7
SwissProt Accessions	Q03172	Gene names	Hivep1, Cryabp1, Znf40
Domain Architecture
Description	Zinc finger protein 40 (Transcription factor alphaA-CRYBP1) (Alpha A- crystallin-binding protein I) (Alpha A-CRYBP1).

CT038_HUMAN
θ value	θ > 10 (rank : 46)	NC score	0.149296 (rank : 11)
Query Neighborhood Hits	45	Target Neighborhood Hits	3	Shared Neighborhood Hits	2
SwissProt Accessions	Q9NUV7, Q5T1U4, Q9H1L1, Q9H1Z0	Gene names	C20orf38
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C20orf38.

Hits sorted by NC score

HEM1_HUMAN
NC score	0.999962 (rank : 1)	θ value	0 (rank : 3)
Query Neighborhood Hits	45	Target Neighborhood Hits	45	Shared Neighborhood Hits	45
SwissProt Accessions	P13196	Gene names	ALAS1, ALASH
Domain Architecture
Description	5-aminolevulinate synthase, nonspecific, mitochondrial precursor (EC 2.3.1.37) (5-aminolevulinic acid synthase) (Delta-aminolevulinate synthase) (Delta-ALA synthetase) (ALAS-H).

HEM1_MOUSE
NC score	0.990798 (rank : 2)	θ value	0 (rank : 4)
Query Neighborhood Hits	45	Target Neighborhood Hits	66	Shared Neighborhood Hits	17
SwissProt Accessions	Q8VC19, Q64453	Gene names	Alas1
Domain Architecture	No domain graphic available
Description	5-aminolevulinate synthase, nonspecific, mitochondrial precursor (EC 2.3.1.37) (5-aminolevulinic acid synthase) (Delta-aminolevulinate synthase) (Delta-ALA synthetase) (ALAS-H).

HEM0_MOUSE
NC score	0.990139 (rank : 3)	θ value	0 (rank : 2)
Query Neighborhood Hits	45	Target Neighborhood Hits	12	Shared Neighborhood Hits	10
SwissProt Accessions	P08680, Q64452, Q9DCN0	Gene names	Alas2
Domain Architecture
Description	5-aminolevulinate synthase, erythroid-specific, mitochondrial precursor (EC 2.3.1.37) (5-aminolevulinic acid synthase) (Delta- aminolevulinate synthase) (Delta-ALA synthetase) (ALAS-E).

HEM0_HUMAN
NC score	0.989898 (rank : 4)	θ value	0 (rank : 1)
Query Neighborhood Hits	45	Target Neighborhood Hits	16	Shared Neighborhood Hits	10
SwissProt Accessions	P22557, Q13735	Gene names	ALAS2, ALASE, ASB
Domain Architecture
Description	5-aminolevulinate synthase, erythroid-specific, mitochondrial precursor (EC 2.3.1.37) (5-aminolevulinic acid synthase) (Delta- aminolevulinate synthase) (Delta-ALA synthetase) (ALAS-E).

KBL_MOUSE
NC score	0.899196 (rank : 5)	θ value	2.84797e-54 (rank : 5)
Query Neighborhood Hits	45	Target Neighborhood Hits	12	Shared Neighborhood Hits	10
SwissProt Accessions	O88986	Gene names	Gcat, Kbl
Domain Architecture
Description	2-amino-3-ketobutyrate coenzyme A ligase, mitochondrial precursor (EC 2.3.1.29) (AKB ligase) (Glycine acetyltransferase).

KBL_HUMAN
NC score	0.895733 (rank : 6)	θ value	1.04822e-48 (rank : 6)
Query Neighborhood Hits	45	Target Neighborhood Hits	13	Shared Neighborhood Hits	10
SwissProt Accessions	O75600, Q96CA9	Gene names	GCAT, KBL
Domain Architecture
Description	2-amino-3-ketobutyrate coenzyme A ligase, mitochondrial precursor (EC 2.3.1.29) (AKB ligase) (Glycine acetyltransferase).

LCB2_MOUSE
NC score	0.818621 (rank : 7)	θ value	1.08726e-37 (rank : 7)
Query Neighborhood Hits	45	Target Neighborhood Hits	12	Shared Neighborhood Hits	10
SwissProt Accessions	P97363, P97356	Gene names	Sptlc2, Lcb2
Domain Architecture
Description	Serine palmitoyltransferase 2 (EC 2.3.1.50) (Long chain base biosynthesis protein 2) (LCB 2) (Serine-palmitoyl-CoA transferase 2) (SPT 2).

LCB2_HUMAN
NC score	0.816389 (rank : 8)	θ value	4.568e-36 (rank : 8)
Query Neighborhood Hits	45	Target Neighborhood Hits	12	Shared Neighborhood Hits	10
SwissProt Accessions	O15270, Q16685	Gene names	SPTLC2, KIAA0526, LCB2
Domain Architecture
Description	Serine palmitoyltransferase 2 (EC 2.3.1.50) (Long chain base biosynthesis protein 2) (LCB 2) (Serine-palmitoyl-CoA transferase 2) (SPT 2).

LCB1_MOUSE
NC score	0.780718 (rank : 9)	θ value	8.08199e-25 (rank : 9)
Query Neighborhood Hits	45	Target Neighborhood Hits	22	Shared Neighborhood Hits	10
SwissProt Accessions	O35704, O54813	Gene names	Sptlc1, Lcb1
Domain Architecture
Description	Serine palmitoyltransferase 1 (EC 2.3.1.50) (Long chain base biosynthesis protein 1) (LCB 1) (Serine-palmitoyl-CoA transferase 1) (SPT 1) (SPT1).

LCB1_HUMAN
NC score	0.778856 (rank : 10)	θ value	4.01107e-24 (rank : 10)
Query Neighborhood Hits	45	Target Neighborhood Hits	21	Shared Neighborhood Hits	10
SwissProt Accessions	O15269	Gene names	SPTLC1, LCB1
Domain Architecture
Description	Serine palmitoyltransferase 1 (EC 2.3.1.50) (Long chain base biosynthesis protein 1) (LCB 1) (Serine-palmitoyl-CoA transferase 1) (SPT 1) (SPT1).

CT038_HUMAN
NC score	0.149296 (rank : 11)	θ value	θ > 10 (rank : 46)
Query Neighborhood Hits	45	Target Neighborhood Hits	3	Shared Neighborhood Hits	2
SwissProt Accessions	Q9NUV7, Q5T1U4, Q9H1L1, Q9H1Z0	Gene names	C20orf38
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C20orf38.

ATE1_HUMAN
NC score	0.025660 (rank : 12)	θ value	8.99809 (rank : 33)
Query Neighborhood Hits	45	Target Neighborhood Hits	11	Shared Neighborhood Hits	3
SwissProt Accessions	O95260, O95261, Q8WW04	Gene names	ATE1
Domain Architecture
Description	Arginyl-tRNA--protein transferase 1 (EC 2.3.2.8) (R-transferase 1) (Arginyltransferase 1) (Arginine-tRNA--protein transferase 1).

CMTA2_MOUSE
NC score	0.021138 (rank : 13)	θ value	1.81305 (rank : 13)
Query Neighborhood Hits	45	Target Neighborhood Hits	216	Shared Neighborhood Hits	4
SwissProt Accessions	Q80Y50, Q3TFK0, Q5SX68, Q80TP1, Q8R0D9, Q8R2N5	Gene names	Camta2, Kiaa0909
Domain Architecture	No domain graphic available
Description	Calmodulin-binding transcription activator 2.

MILK2_HUMAN
NC score	0.018307 (rank : 14)	θ value	0.365318 (rank : 11)
Query Neighborhood Hits	45	Target Neighborhood Hits	457	Shared Neighborhood Hits	6
SwissProt Accessions	Q8IY33, Q7RTP4, Q7Z655, Q8TEQ4, Q9H5F9	Gene names
Domain Architecture
Description	MICAL-like protein 2.

MRP_MOUSE
NC score	0.017803 (rank : 15)	θ value	5.27518 (rank : 21)
Query Neighborhood Hits	45	Target Neighborhood Hits	53	Shared Neighborhood Hits	2
SwissProt Accessions	P28667, Q3TEZ4, Q91W07	Gene names	Marcksl1, Mlp, Mrp
Domain Architecture	No domain graphic available
Description	MARCKS-related protein (MARCKS-like protein 1) (Macrophage myristoylated alanine-rich C kinase substrate) (Mac-MARCKS) (MacMARCKS) (Brain protein F52).

TAF6_HUMAN
NC score	0.017514 (rank : 16)	θ value	5.27518 (rank : 25)
Query Neighborhood Hits	45	Target Neighborhood Hits	127	Shared Neighborhood Hits	6
SwissProt Accessions	P49848	Gene names	TAF6, TAF2E, TAFII70
Domain Architecture
Description	Transcription initiation factor TFIID subunit 6 (Transcription initiation factor TFIID 70 kDa subunit) (TAF(II)70) (TAFII-70) (TAFII- 80) (TAFII80).

GLGB_HUMAN
NC score	0.017317 (rank : 17)	θ value	6.88961 (rank : 28)
Query Neighborhood Hits	45	Target Neighborhood Hits	10	Shared Neighborhood Hits	3
SwissProt Accessions	Q04446, Q96EN0	Gene names	GBE1
Domain Architecture
Description	1,4-alpha-glucan branching enzyme (EC 2.4.1.18) (Glycogen branching enzyme) (Brancher enzyme).

ZC11A_MOUSE
NC score	0.016533 (rank : 18)	θ value	3.0926 (rank : 16)
Query Neighborhood Hits	45	Target Neighborhood Hits	216	Shared Neighborhood Hits	4
SwissProt Accessions	Q6NZF1, Q6NXW9, Q6PDR6, Q80TU7, Q8C5L5, Q99JN6	Gene names	Zc3h11a, Kiaa0663
Domain Architecture	No domain graphic available
Description	Zinc finger CCCH domain-containing protein 11A.

RERE_MOUSE
NC score	0.015687 (rank : 19)	θ value	8.99809 (rank : 40)
Query Neighborhood Hits	45	Target Neighborhood Hits	785	Shared Neighborhood Hits	8
SwissProt Accessions	Q80TZ9	Gene names	Rere, Atr2, Kiaa0458
Domain Architecture	No domain graphic available
Description	Arginine-glutamic acid dipeptide repeats protein (Atrophin-2).

TAF6_MOUSE
NC score	0.015400 (rank : 20)	θ value	8.99809 (rank : 44)
Query Neighborhood Hits	45	Target Neighborhood Hits	110	Shared Neighborhood Hits	5
SwissProt Accessions	Q62311	Gene names	Taf6, Taf2e
Domain Architecture
Description	Transcription initiation factor TFIID subunit 6 (Transcription initiation factor TFIID 70 kDa subunit) (TAF(II)70) (TAFII-70) (TAFII- 80) (TAFII80) (p80).

CJ026_MOUSE
NC score	0.015181 (rank : 21)	θ value	4.03905 (rank : 19)
Query Neighborhood Hits	45	Target Neighborhood Hits	92	Shared Neighborhood Hits	2
SwissProt Accessions	Q8BGW2, Q3TF48, Q3U3M2, Q6PD43, Q8R0W8	Gene names	D19Wsu162e
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C10orf26 homolog.

CN155_HUMAN
NC score	0.015120 (rank : 22)	θ value	3.0926 (rank : 14)
Query Neighborhood Hits	45	Target Neighborhood Hits	385	Shared Neighborhood Hits	7
SwissProt Accessions	Q5H9T9, Q5H9U7, Q86YI2, Q9H0J3	Gene names	C14orf155
Domain Architecture	No domain graphic available
Description	Protein C14orf155.

MLL2_HUMAN
NC score	0.013751 (rank : 23)	θ value	0.62314 (rank : 12)
Query Neighborhood Hits	45	Target Neighborhood Hits	1788	Shared Neighborhood Hits	15
SwissProt Accessions	O14686, O14687	Gene names	MLL2, ALR
Domain Architecture
Description	Myeloid/lymphoid or mixed-lineage leukemia protein 2 (ALL1-related protein).

CNOT6_MOUSE
NC score	0.012254 (rank : 24)	θ value	3.0926 (rank : 15)
Query Neighborhood Hits	45	Target Neighborhood Hits	229	Shared Neighborhood Hits	3
SwissProt Accessions	Q8K3P5, Q5NCL3, Q80V15	Gene names	Cnot6, Ccr4, Kiaa1194
Domain Architecture
Description	CCR4-NOT transcription complex subunit 6 (EC 3.1.-.-) (Cytoplasmic deadenylase) (Carbon catabolite repressor protein 4 homolog) (CCR4 carbon catabolite repression 4-like).

REPS2_HUMAN
NC score	0.012221 (rank : 25)	θ value	4.03905 (rank : 20)
Query Neighborhood Hits	45	Target Neighborhood Hits	131	Shared Neighborhood Hits	4
SwissProt Accessions	Q8NFH8, O43428, Q8NFI5	Gene names	REPS2, POB1
Domain Architecture
Description	RalBP1-associated Eps domain-containing protein 2 (RalBP1-interacting protein 2) (Partner of RalBP1).

T2EB_MOUSE
NC score	0.011041 (rank : 26)	θ value	8.99809 (rank : 43)
Query Neighborhood Hits	45	Target Neighborhood Hits	11	Shared Neighborhood Hits	2
SwissProt Accessions	Q9D902, Q3U5Y7, Q8BTZ2, Q8VE14	Gene names	Gtf2e2
Domain Architecture	No domain graphic available
Description	Transcription initiation factor IIE subunit beta (TFIIE-beta).

CNOT6_HUMAN
NC score	0.010960 (rank : 27)	θ value	6.88961 (rank : 26)
Query Neighborhood Hits	45	Target Neighborhood Hits	225	Shared Neighborhood Hits	3
SwissProt Accessions	Q9ULM6	Gene names	CNOT6, CCR4, KIAA1194
Domain Architecture
Description	CCR4-NOT transcription complex subunit 6 (EC 3.1.-.-) (Cytoplasmic deadenylase) (Carbon catabolite repressor protein 4 homolog) (CCR4 carbon catabolite repression 4-like).

RAE1D_MOUSE
NC score	0.010419 (rank : 28)	θ value	5.27518 (rank : 24)
Query Neighborhood Hits	45	Target Neighborhood Hits	17	Shared Neighborhood Hits	2
SwissProt Accessions	Q9JI58	Gene names	Raet1d
Domain Architecture
Description	Retinoic acid early inducible protein 1 delta precursor (RAE-1delta).

CA103_HUMAN
NC score	0.009578 (rank : 29)	θ value	8.99809 (rank : 34)
Query Neighborhood Hits	45	Target Neighborhood Hits	82	Shared Neighborhood Hits	3
SwissProt Accessions	Q5T3J3, Q86XS4, Q8N3B6, Q96HT4, Q9NUM5, Q9NV32	Gene names	C1orf103, RIF1
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C1orf103 (Receptor-interacting factor 1).

CAF1A_HUMAN
NC score	0.008902 (rank : 30)	θ value	4.03905 (rank : 17)
Query Neighborhood Hits	45	Target Neighborhood Hits	750	Shared Neighborhood Hits	5
SwissProt Accessions	Q13111, Q7Z7K3, Q9UJY8	Gene names	CHAF1A, CAF, CAF1P150
Domain Architecture	No domain graphic available
Description	Chromatin assembly factor 1 subunit A (CAF-1 subunit A) (Chromatin assembly factor I p150 subunit) (CAF-I 150 kDa subunit) (CAF-Ip150).

ENAH_HUMAN
NC score	0.008755 (rank : 31)	θ value	6.88961 (rank : 27)
Query Neighborhood Hits	45	Target Neighborhood Hits	784	Shared Neighborhood Hits	8
SwissProt Accessions	Q8N8S7, Q502W5, Q5T5M7, Q5VTQ9, Q5VTR0, Q9NVF3, Q9UFB8	Gene names	ENAH, MENA
Domain Architecture
Description	Protein enabled homolog.

RERE_HUMAN
NC score	0.008446 (rank : 32)	θ value	6.88961 (rank : 31)
Query Neighborhood Hits	45	Target Neighborhood Hits	779	Shared Neighborhood Hits	9
SwissProt Accessions	Q9P2R6, O43393, O75046, O75359, Q5VXL9, Q6P6B9, Q9Y2W4	Gene names	RERE, ARG, ARP, ATN1L, KIAA0458
Domain Architecture	No domain graphic available
Description	Arginine-glutamic acid dipeptide repeats protein (Atrophin-1-like protein) (Atrophin-1-related protein).

PO6F2_HUMAN
NC score	0.008257 (rank : 33)	θ value	5.27518 (rank : 23)
Query Neighborhood Hits	45	Target Neighborhood Hits	618	Shared Neighborhood Hits	6
SwissProt Accessions	P78424, P78425, Q75ME8, Q86UM6, Q9UDS7	Gene names	POU6F2, RPF1
Domain Architecture
Description	POU domain, class 6, transcription factor 2 (Retina-derived POU-domain factor 1) (RPF-1).

PO121_HUMAN
NC score	0.007190 (rank : 34)	θ value	8.99809 (rank : 39)
Query Neighborhood Hits	45	Target Neighborhood Hits	344	Shared Neighborhood Hits	6
SwissProt Accessions	Q9Y2N3, O75115, Q9Y4S7	Gene names	POM121, KIAA0618, NUP121
Domain Architecture	No domain graphic available
Description	Nuclear envelope pore membrane protein POM 121 (Pore membrane protein of 121 kDa) (P145).

DLGP2_MOUSE
NC score	0.006312 (rank : 35)	θ value	8.99809 (rank : 36)
Query Neighborhood Hits	45	Target Neighborhood Hits	49	Shared Neighborhood Hits	2
SwissProt Accessions	Q8BJ42, Q6XBF3	Gene names	Dlgap2, Dap2
Domain Architecture	No domain graphic available
Description	Disks large-associated protein 2 (DAP-2) (SAP90/PSD-95-associated protein 2) (SAPAP2) (PSD-95/SAP90-binding protein 2).

PAR3L_HUMAN
NC score	0.006053 (rank : 36)	θ value	6.88961 (rank : 30)
Query Neighborhood Hits	45	Target Neighborhood Hits	297	Shared Neighborhood Hits	6
SwissProt Accessions	Q8TEW8, Q8IUC7, Q8IUC9, Q96DK9, Q96N09, Q96NX6, Q96NX7, Q96Q29	Gene names	PARD3B, ALS2CR19, PAR3B, PAR3L
Domain Architecture
Description	Partitioning-defective 3 homolog B (PAR3-beta) (Partitioning-defective 3-like protein) (PAR3-L protein) (Amyotrophic lateral sclerosis 2 chromosome region candidate gene 19 protein).

CHD6_HUMAN
NC score	0.005908 (rank : 37)	θ value	4.03905 (rank : 18)
Query Neighborhood Hits	45	Target Neighborhood Hits	342	Shared Neighborhood Hits	5
SwissProt Accessions	Q8TD26, Q5JYQ0, Q5TGZ9, Q5TH00, Q5TH01, Q8IZR2, Q8WTY0, Q9H4H6, Q9H6D4, Q9NTT7, Q9P2L1	Gene names	CHD6, CHD5, KIAA1335, RIGB
Domain Architecture
Description	Chromodomain-helicase-DNA-binding protein 6 (EC 3.6.1.-) (ATP- dependent helicase CHD6) (CHD-6) (Radiation-induced gene B protein).

PCLO_HUMAN
NC score	0.005338 (rank : 38)	θ value	5.27518 (rank : 22)
Query Neighborhood Hits	45	Target Neighborhood Hits	2046	Shared Neighborhood Hits	21
SwissProt Accessions	Q9Y6V0, O43373, O60305, Q9BVC8, Q9UIV2, Q9Y6U9	Gene names	PCLO, ACZ, KIAA0559
Domain Architecture
Description	Protein piccolo (Aczonin).

RPGF2_HUMAN
NC score	0.005192 (rank : 39)	θ value	8.99809 (rank : 41)
Query Neighborhood Hits	45	Target Neighborhood Hits	242	Shared Neighborhood Hits	3
SwissProt Accessions	Q9Y4G8	Gene names	RAPGEF2, KIAA0313, NRAPGEP, PDZGEF1
Domain Architecture	No domain graphic available
Description	Rap guanine nucleotide exchange factor 2 (Neural RAP guanine nucleotide exchange protein) (nRap GEP) (PDZ domain-containing guanine nucleotide exchange factor 1) (PDZ-GEF1) (RA-GEF).

CBP_MOUSE
NC score	0.005009 (rank : 40)	θ value	8.99809 (rank : 35)
Query Neighborhood Hits	45	Target Neighborhood Hits	1051	Shared Neighborhood Hits	11
SwissProt Accessions	P45481	Gene names	Crebbp, Cbp
Domain Architecture
Description	CREB-binding protein (EC 2.3.1.48).

APOA4_HUMAN
NC score	0.004504 (rank : 41)	θ value	8.99809 (rank : 32)
Query Neighborhood Hits	45	Target Neighborhood Hits	399	Shared Neighborhood Hits	3
SwissProt Accessions	P06727, Q6Q787	Gene names	APOA4
Domain Architecture
Description	Apolipoprotein A-IV precursor (Apo-AIV) (ApoA-IV).

PLXD1_HUMAN
NC score	0.003648 (rank : 42)	θ value	8.99809 (rank : 38)
Query Neighborhood Hits	45	Target Neighborhood Hits	89	Shared Neighborhood Hits	2
SwissProt Accessions	Q9Y4D7, Q6PJS9, Q8IZJ2, Q9BTQ2	Gene names	PLXND1, KIAA0620
Domain Architecture	No domain graphic available
Description	Plexin-D1 precursor.

FGD1_HUMAN
NC score	0.002757 (rank : 43)	θ value	8.99809 (rank : 37)
Query Neighborhood Hits	45	Target Neighborhood Hits	367	Shared Neighborhood Hits	3
SwissProt Accessions	P98174, Q8N4D9	Gene names	FGD1, ZFYVE3
Domain Architecture
Description	FYVE, RhoGEF and PH domain-containing protein 1 (Faciogenital dysplasia 1 protein) (Zinc finger FYVE domain-containing protein 3) (Rho/Rac guanine nucleotide exchange factor FGD1) (Rho/Rac GEF).

ZEP1_MOUSE
NC score	0.000917 (rank : 44)	θ value	8.99809 (rank : 45)
Query Neighborhood Hits	45	Target Neighborhood Hits	1063	Shared Neighborhood Hits	7
SwissProt Accessions	Q03172	Gene names	Hivep1, Cryabp1, Znf40
Domain Architecture
Description	Zinc finger protein 40 (Transcription factor alphaA-CRYBP1) (Alpha A- crystallin-binding protein I) (Alpha A-CRYBP1).

GZF1_HUMAN
NC score	-0.001788 (rank : 45)	θ value	6.88961 (rank : 29)
Query Neighborhood Hits	45	Target Neighborhood Hits	854	Shared Neighborhood Hits	3
SwissProt Accessions	Q9H116, Q96N08, Q9BQK9, Q9H117, Q9H6W6	Gene names	GZF1, ZBTB23, ZNF336
Domain Architecture
Description	GDNF-inducible zinc finger protein 1 (Zinc finger protein 336) (Zinc finger and BTB domain-containing protein 23).

STK10_HUMAN
NC score	-0.002113 (rank : 46)	θ value	8.99809 (rank : 42)
Query Neighborhood Hits	45	Target Neighborhood Hits	1921	Shared Neighborhood Hits	11
SwissProt Accessions	O94804, Q9UIW4	Gene names	STK10, LOK
Domain Architecture
Description	Serine/threonine-protein kinase 10 (EC 2.7.11.1) (Lymphocyte-oriented kinase).