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Network neighborhood for query Sequence : HEM0_HUMAN

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HEM0_HUMAN
SwissProt Accessions	P22557, Q13735	Gene names	ALAS2, ALASE, ASB
Domain Architecture
Description	5-aminolevulinate synthase, erythroid-specific, mitochondrial precursor (EC 2.3.1.37) (5-aminolevulinic acid synthase) (Delta- aminolevulinate synthase) (Delta-ALA synthetase) (ALAS-E).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

HEM0_HUMAN
θ value	0 (rank : 1)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	16	Target Neighborhood Hits	16	Shared Neighborhood Hits	16
SwissProt Accessions	P22557, Q13735	Gene names	ALAS2, ALASE, ASB
Domain Architecture
Description	5-aminolevulinate synthase, erythroid-specific, mitochondrial precursor (EC 2.3.1.37) (5-aminolevulinic acid synthase) (Delta- aminolevulinate synthase) (Delta-ALA synthetase) (ALAS-E).

HEM0_MOUSE
θ value	0 (rank : 2)	NC score	0.999431 (rank : 2)
Query Neighborhood Hits	16	Target Neighborhood Hits	12	Shared Neighborhood Hits	12
SwissProt Accessions	P08680, Q64452, Q9DCN0	Gene names	Alas2
Domain Architecture
Description	5-aminolevulinate synthase, erythroid-specific, mitochondrial precursor (EC 2.3.1.37) (5-aminolevulinic acid synthase) (Delta- aminolevulinate synthase) (Delta-ALA synthetase) (ALAS-E).

HEM1_HUMAN
θ value	0 (rank : 3)	NC score	0.989898 (rank : 3)
Query Neighborhood Hits	16	Target Neighborhood Hits	45	Shared Neighborhood Hits	10
SwissProt Accessions	P13196	Gene names	ALAS1, ALASH
Domain Architecture
Description	5-aminolevulinate synthase, nonspecific, mitochondrial precursor (EC 2.3.1.37) (5-aminolevulinic acid synthase) (Delta-aminolevulinate synthase) (Delta-ALA synthetase) (ALAS-H).

HEM1_MOUSE
θ value	0 (rank : 4)	NC score	0.984095 (rank : 4)
Query Neighborhood Hits	16	Target Neighborhood Hits	66	Shared Neighborhood Hits	10
SwissProt Accessions	Q8VC19, Q64453	Gene names	Alas1
Domain Architecture	No domain graphic available
Description	5-aminolevulinate synthase, nonspecific, mitochondrial precursor (EC 2.3.1.37) (5-aminolevulinic acid synthase) (Delta-aminolevulinate synthase) (Delta-ALA synthetase) (ALAS-H).

KBL_MOUSE
θ value	2.03627e-60 (rank : 5)	NC score	0.912661 (rank : 5)
Query Neighborhood Hits	16	Target Neighborhood Hits	12	Shared Neighborhood Hits	10
SwissProt Accessions	O88986	Gene names	Gcat, Kbl
Domain Architecture
Description	2-amino-3-ketobutyrate coenzyme A ligase, mitochondrial precursor (EC 2.3.1.29) (AKB ligase) (Glycine acetyltransferase).

KBL_HUMAN
θ value	3.25095e-58 (rank : 6)	NC score	0.910329 (rank : 6)
Query Neighborhood Hits	16	Target Neighborhood Hits	13	Shared Neighborhood Hits	10
SwissProt Accessions	O75600, Q96CA9	Gene names	GCAT, KBL
Domain Architecture
Description	2-amino-3-ketobutyrate coenzyme A ligase, mitochondrial precursor (EC 2.3.1.29) (AKB ligase) (Glycine acetyltransferase).

LCB2_HUMAN
θ value	1.85459e-37 (rank : 7)	NC score	0.824639 (rank : 8)
Query Neighborhood Hits	16	Target Neighborhood Hits	12	Shared Neighborhood Hits	10
SwissProt Accessions	O15270, Q16685	Gene names	SPTLC2, KIAA0526, LCB2
Domain Architecture
Description	Serine palmitoyltransferase 2 (EC 2.3.1.50) (Long chain base biosynthesis protein 2) (LCB 2) (Serine-palmitoyl-CoA transferase 2) (SPT 2).

LCB2_MOUSE
θ value	3.16345e-37 (rank : 8)	NC score	0.826137 (rank : 7)
Query Neighborhood Hits	16	Target Neighborhood Hits	12	Shared Neighborhood Hits	10
SwissProt Accessions	P97363, P97356	Gene names	Sptlc2, Lcb2
Domain Architecture
Description	Serine palmitoyltransferase 2 (EC 2.3.1.50) (Long chain base biosynthesis protein 2) (LCB 2) (Serine-palmitoyl-CoA transferase 2) (SPT 2).

LCB1_MOUSE
θ value	2.68423e-28 (rank : 9)	NC score	0.796686 (rank : 9)
Query Neighborhood Hits	16	Target Neighborhood Hits	22	Shared Neighborhood Hits	10
SwissProt Accessions	O35704, O54813	Gene names	Sptlc1, Lcb1
Domain Architecture
Description	Serine palmitoyltransferase 1 (EC 2.3.1.50) (Long chain base biosynthesis protein 1) (LCB 1) (Serine-palmitoyl-CoA transferase 1) (SPT 1) (SPT1).

LCB1_HUMAN
θ value	5.97985e-28 (rank : 10)	NC score	0.795048 (rank : 10)
Query Neighborhood Hits	16	Target Neighborhood Hits	21	Shared Neighborhood Hits	10
SwissProt Accessions	O15269	Gene names	SPTLC1, LCB1
Domain Architecture
Description	Serine palmitoyltransferase 1 (EC 2.3.1.50) (Long chain base biosynthesis protein 1) (LCB 1) (Serine-palmitoyl-CoA transferase 1) (SPT 1) (SPT1).

VINEX_MOUSE
θ value	1.06291 (rank : 11)	NC score	0.014053 (rank : 14)
Query Neighborhood Hits	16	Target Neighborhood Hits	286	Shared Neighborhood Hits	2
SwissProt Accessions	Q9R1Z8, Q62423	Gene names	Sorbs3, Scam1, Sh3d4
Domain Architecture
Description	Vinexin (Sorbin and SH3 domain-containing protein 3) (SH3-containing adapter molecule 1) (SCAM-1) (SH3 domain-containing protein SH3P3).

GABR1_HUMAN
θ value	3.0926 (rank : 12)	NC score	0.019035 (rank : 12)
Query Neighborhood Hits	16	Target Neighborhood Hits	142	Shared Neighborhood Hits	3
SwissProt Accessions	Q9UBS5, O95375, O95468, O95975, O96022, Q86W60, Q9UQQ0	Gene names	GABBR1, GPRC3A
Domain Architecture
Description	Gamma-aminobutyric acid type B receptor, subunit 1 precursor (GABA-B receptor 1) (GABA-B-R1) (Gb1).

GABR1_MOUSE
θ value	3.0926 (rank : 13)	NC score	0.018996 (rank : 13)
Query Neighborhood Hits	16	Target Neighborhood Hits	139	Shared Neighborhood Hits	3
SwissProt Accessions	Q9WV18, Q9WU48, Q9WV15, Q9WV16, Q9WV17	Gene names	Gabbr1
Domain Architecture
Description	Gamma-aminobutyric acid type B receptor, subunit 1 precursor (GABA-B receptor 1) (GABA-B-R1) (Gb1).

MRP5_MOUSE
θ value	3.0926 (rank : 14)	NC score	0.011484 (rank : 15)
Query Neighborhood Hits	16	Target Neighborhood Hits	99	Shared Neighborhood Hits	4
SwissProt Accessions	Q9R1X5, O88284	Gene names	Abcc5, Abcc5a, Mrp5
Domain Architecture
Description	Multidrug resistance-associated protein 5 (ATP-binding cassette sub- family C member 5) (ABC transporter MOAT-C) (SMRP).

MRP5_HUMAN
θ value	4.03905 (rank : 15)	NC score	0.010772 (rank : 16)
Query Neighborhood Hits	16	Target Neighborhood Hits	110	Shared Neighborhood Hits	4
SwissProt Accessions	O15440, O14517, Q9UN85, Q9UNP5, Q9UQC3	Gene names	ABCC5, MRP5
Domain Architecture
Description	Multidrug resistance-associated protein 5 (ATP-binding cassette sub- family C member 5) (Multi-specific organic anion transporter-C) (MOAT- C) (pABC11) (SMRP).

FAS_HUMAN
θ value	8.99809 (rank : 16)	NC score	0.006989 (rank : 17)
Query Neighborhood Hits	16	Target Neighborhood Hits	66	Shared Neighborhood Hits	2
SwissProt Accessions	P49327, Q13479, Q16702, Q6P4U5, Q6SS02, Q969R1, Q96C68, Q96IT0	Gene names	FASN, FAS
Domain Architecture
Description	Fatty acid synthase (EC 2.3.1.85) [Includes: [Acyl-carrier-protein] S- acetyltransferase (EC 2.3.1.38); [Acyl-carrier-protein] S- malonyltransferase (EC 2.3.1.39); 3-oxoacyl-[acyl-carrier-protein] synthase (EC 2.3.1.41); 3-oxoacyl-[acyl-carrier-protein] reductase (EC 1.1.1.100); 3-hydroxypalmitoyl-[acyl-carrier-protein] dehydratase (EC 4.2.1.61); Enoyl-[acyl-carrier-protein] reductase (EC 1.3.1.10); Oleoyl-[acyl-carrier-protein] hydrolase (EC 3.1.2.14)].

CT038_HUMAN
θ value	θ > 10 (rank : 17)	NC score	0.149392 (rank : 11)
Query Neighborhood Hits	16	Target Neighborhood Hits	3	Shared Neighborhood Hits	2
SwissProt Accessions	Q9NUV7, Q5T1U4, Q9H1L1, Q9H1Z0	Gene names	C20orf38
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C20orf38.

Hits sorted by NC score

HEM0_HUMAN
NC score	0.999962 (rank : 1)	θ value	0 (rank : 1)
Query Neighborhood Hits	16	Target Neighborhood Hits	16	Shared Neighborhood Hits	16
SwissProt Accessions	P22557, Q13735	Gene names	ALAS2, ALASE, ASB
Domain Architecture
Description	5-aminolevulinate synthase, erythroid-specific, mitochondrial precursor (EC 2.3.1.37) (5-aminolevulinic acid synthase) (Delta- aminolevulinate synthase) (Delta-ALA synthetase) (ALAS-E).

HEM0_MOUSE
NC score	0.999431 (rank : 2)	θ value	0 (rank : 2)
Query Neighborhood Hits	16	Target Neighborhood Hits	12	Shared Neighborhood Hits	12
SwissProt Accessions	P08680, Q64452, Q9DCN0	Gene names	Alas2
Domain Architecture
Description	5-aminolevulinate synthase, erythroid-specific, mitochondrial precursor (EC 2.3.1.37) (5-aminolevulinic acid synthase) (Delta- aminolevulinate synthase) (Delta-ALA synthetase) (ALAS-E).

HEM1_HUMAN
NC score	0.989898 (rank : 3)	θ value	0 (rank : 3)
Query Neighborhood Hits	16	Target Neighborhood Hits	45	Shared Neighborhood Hits	10
SwissProt Accessions	P13196	Gene names	ALAS1, ALASH
Domain Architecture
Description	5-aminolevulinate synthase, nonspecific, mitochondrial precursor (EC 2.3.1.37) (5-aminolevulinic acid synthase) (Delta-aminolevulinate synthase) (Delta-ALA synthetase) (ALAS-H).

HEM1_MOUSE
NC score	0.984095 (rank : 4)	θ value	0 (rank : 4)
Query Neighborhood Hits	16	Target Neighborhood Hits	66	Shared Neighborhood Hits	10
SwissProt Accessions	Q8VC19, Q64453	Gene names	Alas1
Domain Architecture	No domain graphic available
Description	5-aminolevulinate synthase, nonspecific, mitochondrial precursor (EC 2.3.1.37) (5-aminolevulinic acid synthase) (Delta-aminolevulinate synthase) (Delta-ALA synthetase) (ALAS-H).

KBL_MOUSE
NC score	0.912661 (rank : 5)	θ value	2.03627e-60 (rank : 5)
Query Neighborhood Hits	16	Target Neighborhood Hits	12	Shared Neighborhood Hits	10
SwissProt Accessions	O88986	Gene names	Gcat, Kbl
Domain Architecture
Description	2-amino-3-ketobutyrate coenzyme A ligase, mitochondrial precursor (EC 2.3.1.29) (AKB ligase) (Glycine acetyltransferase).

KBL_HUMAN
NC score	0.910329 (rank : 6)	θ value	3.25095e-58 (rank : 6)
Query Neighborhood Hits	16	Target Neighborhood Hits	13	Shared Neighborhood Hits	10
SwissProt Accessions	O75600, Q96CA9	Gene names	GCAT, KBL
Domain Architecture
Description	2-amino-3-ketobutyrate coenzyme A ligase, mitochondrial precursor (EC 2.3.1.29) (AKB ligase) (Glycine acetyltransferase).

LCB2_MOUSE
NC score	0.826137 (rank : 7)	θ value	3.16345e-37 (rank : 8)
Query Neighborhood Hits	16	Target Neighborhood Hits	12	Shared Neighborhood Hits	10
SwissProt Accessions	P97363, P97356	Gene names	Sptlc2, Lcb2
Domain Architecture
Description	Serine palmitoyltransferase 2 (EC 2.3.1.50) (Long chain base biosynthesis protein 2) (LCB 2) (Serine-palmitoyl-CoA transferase 2) (SPT 2).

LCB2_HUMAN
NC score	0.824639 (rank : 8)	θ value	1.85459e-37 (rank : 7)
Query Neighborhood Hits	16	Target Neighborhood Hits	12	Shared Neighborhood Hits	10
SwissProt Accessions	O15270, Q16685	Gene names	SPTLC2, KIAA0526, LCB2
Domain Architecture
Description	Serine palmitoyltransferase 2 (EC 2.3.1.50) (Long chain base biosynthesis protein 2) (LCB 2) (Serine-palmitoyl-CoA transferase 2) (SPT 2).

LCB1_MOUSE
NC score	0.796686 (rank : 9)	θ value	2.68423e-28 (rank : 9)
Query Neighborhood Hits	16	Target Neighborhood Hits	22	Shared Neighborhood Hits	10
SwissProt Accessions	O35704, O54813	Gene names	Sptlc1, Lcb1
Domain Architecture
Description	Serine palmitoyltransferase 1 (EC 2.3.1.50) (Long chain base biosynthesis protein 1) (LCB 1) (Serine-palmitoyl-CoA transferase 1) (SPT 1) (SPT1).

LCB1_HUMAN
NC score	0.795048 (rank : 10)	θ value	5.97985e-28 (rank : 10)
Query Neighborhood Hits	16	Target Neighborhood Hits	21	Shared Neighborhood Hits	10
SwissProt Accessions	O15269	Gene names	SPTLC1, LCB1
Domain Architecture
Description	Serine palmitoyltransferase 1 (EC 2.3.1.50) (Long chain base biosynthesis protein 1) (LCB 1) (Serine-palmitoyl-CoA transferase 1) (SPT 1) (SPT1).

CT038_HUMAN
NC score	0.149392 (rank : 11)	θ value	θ > 10 (rank : 17)
Query Neighborhood Hits	16	Target Neighborhood Hits	3	Shared Neighborhood Hits	2
SwissProt Accessions	Q9NUV7, Q5T1U4, Q9H1L1, Q9H1Z0	Gene names	C20orf38
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C20orf38.

GABR1_HUMAN
NC score	0.019035 (rank : 12)	θ value	3.0926 (rank : 12)
Query Neighborhood Hits	16	Target Neighborhood Hits	142	Shared Neighborhood Hits	3
SwissProt Accessions	Q9UBS5, O95375, O95468, O95975, O96022, Q86W60, Q9UQQ0	Gene names	GABBR1, GPRC3A
Domain Architecture
Description	Gamma-aminobutyric acid type B receptor, subunit 1 precursor (GABA-B receptor 1) (GABA-B-R1) (Gb1).

GABR1_MOUSE
NC score	0.018996 (rank : 13)	θ value	3.0926 (rank : 13)
Query Neighborhood Hits	16	Target Neighborhood Hits	139	Shared Neighborhood Hits	3
SwissProt Accessions	Q9WV18, Q9WU48, Q9WV15, Q9WV16, Q9WV17	Gene names	Gabbr1
Domain Architecture
Description	Gamma-aminobutyric acid type B receptor, subunit 1 precursor (GABA-B receptor 1) (GABA-B-R1) (Gb1).

VINEX_MOUSE
NC score	0.014053 (rank : 14)	θ value	1.06291 (rank : 11)
Query Neighborhood Hits	16	Target Neighborhood Hits	286	Shared Neighborhood Hits	2
SwissProt Accessions	Q9R1Z8, Q62423	Gene names	Sorbs3, Scam1, Sh3d4
Domain Architecture
Description	Vinexin (Sorbin and SH3 domain-containing protein 3) (SH3-containing adapter molecule 1) (SCAM-1) (SH3 domain-containing protein SH3P3).

MRP5_MOUSE
NC score	0.011484 (rank : 15)	θ value	3.0926 (rank : 14)
Query Neighborhood Hits	16	Target Neighborhood Hits	99	Shared Neighborhood Hits	4
SwissProt Accessions	Q9R1X5, O88284	Gene names	Abcc5, Abcc5a, Mrp5
Domain Architecture
Description	Multidrug resistance-associated protein 5 (ATP-binding cassette sub- family C member 5) (ABC transporter MOAT-C) (SMRP).

MRP5_HUMAN
NC score	0.010772 (rank : 16)	θ value	4.03905 (rank : 15)
Query Neighborhood Hits	16	Target Neighborhood Hits	110	Shared Neighborhood Hits	4
SwissProt Accessions	O15440, O14517, Q9UN85, Q9UNP5, Q9UQC3	Gene names	ABCC5, MRP5
Domain Architecture
Description	Multidrug resistance-associated protein 5 (ATP-binding cassette sub- family C member 5) (Multi-specific organic anion transporter-C) (MOAT- C) (pABC11) (SMRP).

FAS_HUMAN
NC score	0.006989 (rank : 17)	θ value	8.99809 (rank : 16)
Query Neighborhood Hits	16	Target Neighborhood Hits	66	Shared Neighborhood Hits	2
SwissProt Accessions	P49327, Q13479, Q16702, Q6P4U5, Q6SS02, Q969R1, Q96C68, Q96IT0	Gene names	FASN, FAS
Domain Architecture
Description	Fatty acid synthase (EC 2.3.1.85) [Includes: [Acyl-carrier-protein] S- acetyltransferase (EC 2.3.1.38); [Acyl-carrier-protein] S- malonyltransferase (EC 2.3.1.39); 3-oxoacyl-[acyl-carrier-protein] synthase (EC 2.3.1.41); 3-oxoacyl-[acyl-carrier-protein] reductase (EC 1.1.1.100); 3-hydroxypalmitoyl-[acyl-carrier-protein] dehydratase (EC 4.2.1.61); Enoyl-[acyl-carrier-protein] reductase (EC 1.3.1.10); Oleoyl-[acyl-carrier-protein] hydrolase (EC 3.1.2.14)].