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Network neighborhood for query Sequence : CPSF1_HUMAN

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CPSF1_HUMAN
SwissProt Accessions	Q10570, Q96AF0	Gene names	CPSF1, CPSF160
Domain Architecture
Description	Cleavage and polyadenylation specificity factor 160 kDa subunit (CPSF 160 kDa subunit).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

CPSF1_HUMAN
θ value	0 (rank : 1)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	22	Target Neighborhood Hits	22	Shared Neighborhood Hits	22
SwissProt Accessions	Q10570, Q96AF0	Gene names	CPSF1, CPSF160
Domain Architecture
Description	Cleavage and polyadenylation specificity factor 160 kDa subunit (CPSF 160 kDa subunit).

CPSF1_MOUSE
θ value	0 (rank : 2)	NC score	0.998197 (rank : 2)
Query Neighborhood Hits	22	Target Neighborhood Hits	22	Shared Neighborhood Hits	14
SwissProt Accessions	Q9EPU4	Gene names	Cpsf1, Cpsf160
Domain Architecture
Description	Cleavage and polyadenylation specificity factor 160 kDa subunit (CPSF 160 kDa subunit).

DDB1_HUMAN
θ value	1.80466e-16 (rank : 3)	NC score	0.500752 (rank : 3)
Query Neighborhood Hits	22	Target Neighborhood Hits	15	Shared Neighborhood Hits	5
SwissProt Accessions	Q16531, O15176, Q13289, Q58F96	Gene names	DDB1
Domain Architecture
Description	DNA damage-binding protein 1 (Damage-specific DNA-binding protein 1) (UV-damaged DNA-binding factor) (DDB p127 subunit) (DDBa) (UV-damaged DNA-binding protein 1) (UV-DDB 1) (Xeroderma pigmentosum group E- complementing protein) (XPCe) (XPE-binding factor) (XPE-BF) (X- associated protein 1) (XAP-1).

SF3B3_HUMAN
θ value	6.41864e-14 (rank : 4)	NC score	0.466268 (rank : 4)
Query Neighborhood Hits	22	Target Neighborhood Hits	19	Shared Neighborhood Hits	4
SwissProt Accessions	Q15393, Q9UJ29	Gene names	SF3B3, KIAA0017, SAP130
Domain Architecture
Description	Splicing factor 3B subunit 3 (Spliceosome-associated protein 130) (SAP 130) (SF3b130) (Pre-mRNA-splicing factor SF3b 130 kDa subunit) (STAF130).

HXC11_HUMAN
θ value	0.163984 (rank : 5)	NC score	0.025359 (rank : 10)
Query Neighborhood Hits	22	Target Neighborhood Hits	349	Shared Neighborhood Hits	4
SwissProt Accessions	O43248, Q96DH2	Gene names	HOXC11
Domain Architecture
Description	Homeobox protein Hox-C11.

RFIP5_MOUSE
θ value	1.06291 (rank : 6)	NC score	0.045055 (rank : 5)
Query Neighborhood Hits	22	Target Neighborhood Hits	126	Shared Neighborhood Hits	4
SwissProt Accessions	Q8R361	Gene names	Rab11fip5, D6Ertd32e, Rip11
Domain Architecture	No domain graphic available
Description	Rab11 family-interacting protein 5 (Rab11-FIP5) (Rab11-interacting protein Rip11).

FMOD_MOUSE
θ value	1.38821 (rank : 7)	NC score	0.019797 (rank : 12)
Query Neighborhood Hits	22	Target Neighborhood Hits	286	Shared Neighborhood Hits	6
SwissProt Accessions	P50608	Gene names	Fmod
Domain Architecture
Description	Fibromodulin precursor (FM) (Collagen-binding 59 kDa protein) (Keratan sulfate proteoglycan fibromodulin) (KSPG fibromodulin).

SCN9A_HUMAN
θ value	1.38821 (rank : 8)	NC score	0.010774 (rank : 19)
Query Neighborhood Hits	22	Target Neighborhood Hits	157	Shared Neighborhood Hits	2
SwissProt Accessions	Q15858, Q6B4R9, Q6B4S0, Q6B4S1, Q70HX1, Q70HX2, Q8WTU1, Q8WWN4	Gene names	SCN9A, NENA, PN1
Domain Architecture	No domain graphic available
Description	Sodium channel protein type 9 subunit alpha (Sodium channel protein type IX subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.7) (Neuroendocrine sodium channel) (hNE-Na) (Peripheral sodium channel 1).

SIRT1_MOUSE
θ value	1.38821 (rank : 9)	NC score	0.039026 (rank : 6)
Query Neighborhood Hits	22	Target Neighborhood Hits	50	Shared Neighborhood Hits	3
SwissProt Accessions	Q923E4, Q9QXG8	Gene names	Sirt1, Sir2l1
Domain Architecture
Description	NAD-dependent deacetylase sirtuin-1 (EC 3.5.1.-) (SIR2alpha) (mSIR2a) (Sir2) (SIR2-like protein 1).

NIN_HUMAN
θ value	2.36792 (rank : 10)	NC score	0.007293 (rank : 22)
Query Neighborhood Hits	22	Target Neighborhood Hits	1416	Shared Neighborhood Hits	3
SwissProt Accessions	Q8N4C6, Q6P0P6, Q9BWU6, Q9C012, Q9C013, Q9C014, Q9H5I6, Q9HAT7, Q9HBY5, Q9HCK7, Q9UH61	Gene names	NIN, KIAA1565
Domain Architecture	No domain graphic available
Description	Ninein (hNinein) (Glycogen synthase kinase 3 beta-interacting protein) (GSK3B-interacting protein).

CCNI_MOUSE
θ value	3.0926 (rank : 11)	NC score	0.037688 (rank : 7)
Query Neighborhood Hits	22	Target Neighborhood Hits	35	Shared Neighborhood Hits	4
SwissProt Accessions	Q9Z2V9	Gene names	Ccni
Domain Architecture
Description	Cyclin-I.

LRCH1_MOUSE
θ value	3.0926 (rank : 12)	NC score	0.013369 (rank : 15)
Query Neighborhood Hits	22	Target Neighborhood Hits	264	Shared Neighborhood Hits	5
SwissProt Accessions	P62046	Gene names	Lrch1, Chdc1, Kiaa1016
Domain Architecture
Description	Leucine-rich repeats and calponin homology domain-containing protein 1 (Calponin homology domain-containing protein 1).

AHR_MOUSE
θ value	4.03905 (rank : 13)	NC score	0.014029 (rank : 14)
Query Neighborhood Hits	22	Target Neighborhood Hits	55	Shared Neighborhood Hits	2
SwissProt Accessions	P30561, Q8QZX6, Q8R4S3, Q99P79, Q9QVY1	Gene names	Ahr
Domain Architecture
Description	Aryl hydrocarbon receptor precursor (Ah receptor) (AhR).

FMOD_HUMAN
θ value	4.03905 (rank : 14)	NC score	0.014771 (rank : 13)
Query Neighborhood Hits	22	Target Neighborhood Hits	283	Shared Neighborhood Hits	6
SwissProt Accessions	Q06828, Q15331	Gene names	FMOD, FM
Domain Architecture
Description	Fibromodulin precursor (FM) (Collagen-binding 59 kDa protein) (Keratan sulfate proteoglycan fibromodulin) (KSPG fibromodulin).

CCNI_HUMAN
θ value	5.27518 (rank : 15)	NC score	0.031339 (rank : 8)
Query Neighborhood Hits	22	Target Neighborhood Hits	39	Shared Neighborhood Hits	4
SwissProt Accessions	Q14094	Gene names	CCNI
Domain Architecture
Description	Cyclin-I.

PKNX2_HUMAN
θ value	5.27518 (rank : 16)	NC score	0.011151 (rank : 18)
Query Neighborhood Hits	22	Target Neighborhood Hits	133	Shared Neighborhood Hits	3
SwissProt Accessions	Q96KN3, Q63HL6, Q86XD1	Gene names	PKNOX2, PREP2
Domain Architecture
Description	Homeobox protein PKNOX2 (PBX/knotted homeobox 2) (Homeobox protein PREP-2).

TBX21_HUMAN
θ value	5.27518 (rank : 17)	NC score	0.007953 (rank : 21)
Query Neighborhood Hits	22	Target Neighborhood Hits	146	Shared Neighborhood Hits	2
SwissProt Accessions	Q9UL17	Gene names	TBX21, TBET, TBLYM
Domain Architecture
Description	T-box transcription factor TBX21 (T-box protein 21) (Transcription factor TBLYM) (T-cell-specific T-box transcription factor T-bet).

MATR3_MOUSE
θ value	6.88961 (rank : 18)	NC score	0.012248 (rank : 16)
Query Neighborhood Hits	22	Target Neighborhood Hits	321	Shared Neighborhood Hits	2
SwissProt Accessions	Q8K310	Gene names	Matr3
Domain Architecture	No domain graphic available
Description	Matrin-3.

CABP4_HUMAN
θ value	8.99809 (rank : 19)	NC score	0.011589 (rank : 17)
Query Neighborhood Hits	22	Target Neighborhood Hits	250	Shared Neighborhood Hits	3
SwissProt Accessions	P57796, Q8N4Z2, Q8WWY5	Gene names	CABP4
Domain Architecture
Description	Calcium-binding protein 4 (CaBP4).

DOT1L_HUMAN
θ value	8.99809 (rank : 20)	NC score	0.020141 (rank : 11)
Query Neighborhood Hits	22	Target Neighborhood Hits	660	Shared Neighborhood Hits	4
SwissProt Accessions	Q8TEK3, O60379, Q96JL1	Gene names	DOT1L, KIAA1814
Domain Architecture	No domain graphic available
Description	Histone-lysine N-methyltransferase, H3 lysine-79 specific (EC 2.1.1.43) (Histone H3-K79 methyltransferase) (H3-K79-HMTase) (DOT1-like protein).

LRCH1_HUMAN
θ value	8.99809 (rank : 21)	NC score	0.010215 (rank : 20)
Query Neighborhood Hits	22	Target Neighborhood Hits	266	Shared Neighborhood Hits	5
SwissProt Accessions	Q9Y2L9, Q7Z5F6, Q7Z5F7	Gene names	LRCH1, CHDC1, KIAA1016
Domain Architecture
Description	Leucine-rich repeats and calponin homology domain-containing protein 1 (Calponin homology domain-containing protein 1) (Neuronal protein 81) (NP81).

SPEB_HUMAN
θ value	8.99809 (rank : 22)	NC score	0.029443 (rank : 9)
Query Neighborhood Hits	22	Target Neighborhood Hits	12	Shared Neighborhood Hits	3
SwissProt Accessions	Q9BSE5, Q5TDH1, Q9H5J3	Gene names	AGMAT
Domain Architecture
Description	Agmatinase, mitochondrial precursor (EC 3.5.3.11) (Agmatine ureohydrolase) (AUH).

Hits sorted by NC score

CPSF1_HUMAN
NC score	0.999962 (rank : 1)	θ value	0 (rank : 1)
Query Neighborhood Hits	22	Target Neighborhood Hits	22	Shared Neighborhood Hits	22
SwissProt Accessions	Q10570, Q96AF0	Gene names	CPSF1, CPSF160
Domain Architecture
Description	Cleavage and polyadenylation specificity factor 160 kDa subunit (CPSF 160 kDa subunit).

CPSF1_MOUSE
NC score	0.998197 (rank : 2)	θ value	0 (rank : 2)
Query Neighborhood Hits	22	Target Neighborhood Hits	22	Shared Neighborhood Hits	14
SwissProt Accessions	Q9EPU4	Gene names	Cpsf1, Cpsf160
Domain Architecture
Description	Cleavage and polyadenylation specificity factor 160 kDa subunit (CPSF 160 kDa subunit).

DDB1_HUMAN
NC score	0.500752 (rank : 3)	θ value	1.80466e-16 (rank : 3)
Query Neighborhood Hits	22	Target Neighborhood Hits	15	Shared Neighborhood Hits	5
SwissProt Accessions	Q16531, O15176, Q13289, Q58F96	Gene names	DDB1
Domain Architecture
Description	DNA damage-binding protein 1 (Damage-specific DNA-binding protein 1) (UV-damaged DNA-binding factor) (DDB p127 subunit) (DDBa) (UV-damaged DNA-binding protein 1) (UV-DDB 1) (Xeroderma pigmentosum group E- complementing protein) (XPCe) (XPE-binding factor) (XPE-BF) (X- associated protein 1) (XAP-1).

SF3B3_HUMAN
NC score	0.466268 (rank : 4)	θ value	6.41864e-14 (rank : 4)
Query Neighborhood Hits	22	Target Neighborhood Hits	19	Shared Neighborhood Hits	4
SwissProt Accessions	Q15393, Q9UJ29	Gene names	SF3B3, KIAA0017, SAP130
Domain Architecture
Description	Splicing factor 3B subunit 3 (Spliceosome-associated protein 130) (SAP 130) (SF3b130) (Pre-mRNA-splicing factor SF3b 130 kDa subunit) (STAF130).

RFIP5_MOUSE
NC score	0.045055 (rank : 5)	θ value	1.06291 (rank : 6)
Query Neighborhood Hits	22	Target Neighborhood Hits	126	Shared Neighborhood Hits	4
SwissProt Accessions	Q8R361	Gene names	Rab11fip5, D6Ertd32e, Rip11
Domain Architecture	No domain graphic available
Description	Rab11 family-interacting protein 5 (Rab11-FIP5) (Rab11-interacting protein Rip11).

SIRT1_MOUSE
NC score	0.039026 (rank : 6)	θ value	1.38821 (rank : 9)
Query Neighborhood Hits	22	Target Neighborhood Hits	50	Shared Neighborhood Hits	3
SwissProt Accessions	Q923E4, Q9QXG8	Gene names	Sirt1, Sir2l1
Domain Architecture
Description	NAD-dependent deacetylase sirtuin-1 (EC 3.5.1.-) (SIR2alpha) (mSIR2a) (Sir2) (SIR2-like protein 1).

CCNI_MOUSE
NC score	0.037688 (rank : 7)	θ value	3.0926 (rank : 11)
Query Neighborhood Hits	22	Target Neighborhood Hits	35	Shared Neighborhood Hits	4
SwissProt Accessions	Q9Z2V9	Gene names	Ccni
Domain Architecture
Description	Cyclin-I.

CCNI_HUMAN
NC score	0.031339 (rank : 8)	θ value	5.27518 (rank : 15)
Query Neighborhood Hits	22	Target Neighborhood Hits	39	Shared Neighborhood Hits	4
SwissProt Accessions	Q14094	Gene names	CCNI
Domain Architecture
Description	Cyclin-I.

SPEB_HUMAN
NC score	0.029443 (rank : 9)	θ value	8.99809 (rank : 22)
Query Neighborhood Hits	22	Target Neighborhood Hits	12	Shared Neighborhood Hits	3
SwissProt Accessions	Q9BSE5, Q5TDH1, Q9H5J3	Gene names	AGMAT
Domain Architecture
Description	Agmatinase, mitochondrial precursor (EC 3.5.3.11) (Agmatine ureohydrolase) (AUH).

HXC11_HUMAN
NC score	0.025359 (rank : 10)	θ value	0.163984 (rank : 5)
Query Neighborhood Hits	22	Target Neighborhood Hits	349	Shared Neighborhood Hits	4
SwissProt Accessions	O43248, Q96DH2	Gene names	HOXC11
Domain Architecture
Description	Homeobox protein Hox-C11.

DOT1L_HUMAN
NC score	0.020141 (rank : 11)	θ value	8.99809 (rank : 20)
Query Neighborhood Hits	22	Target Neighborhood Hits	660	Shared Neighborhood Hits	4
SwissProt Accessions	Q8TEK3, O60379, Q96JL1	Gene names	DOT1L, KIAA1814
Domain Architecture	No domain graphic available
Description	Histone-lysine N-methyltransferase, H3 lysine-79 specific (EC 2.1.1.43) (Histone H3-K79 methyltransferase) (H3-K79-HMTase) (DOT1-like protein).

FMOD_MOUSE
NC score	0.019797 (rank : 12)	θ value	1.38821 (rank : 7)
Query Neighborhood Hits	22	Target Neighborhood Hits	286	Shared Neighborhood Hits	6
SwissProt Accessions	P50608	Gene names	Fmod
Domain Architecture
Description	Fibromodulin precursor (FM) (Collagen-binding 59 kDa protein) (Keratan sulfate proteoglycan fibromodulin) (KSPG fibromodulin).

FMOD_HUMAN
NC score	0.014771 (rank : 13)	θ value	4.03905 (rank : 14)
Query Neighborhood Hits	22	Target Neighborhood Hits	283	Shared Neighborhood Hits	6
SwissProt Accessions	Q06828, Q15331	Gene names	FMOD, FM
Domain Architecture
Description	Fibromodulin precursor (FM) (Collagen-binding 59 kDa protein) (Keratan sulfate proteoglycan fibromodulin) (KSPG fibromodulin).

AHR_MOUSE
NC score	0.014029 (rank : 14)	θ value	4.03905 (rank : 13)
Query Neighborhood Hits	22	Target Neighborhood Hits	55	Shared Neighborhood Hits	2
SwissProt Accessions	P30561, Q8QZX6, Q8R4S3, Q99P79, Q9QVY1	Gene names	Ahr
Domain Architecture
Description	Aryl hydrocarbon receptor precursor (Ah receptor) (AhR).

LRCH1_MOUSE
NC score	0.013369 (rank : 15)	θ value	3.0926 (rank : 12)
Query Neighborhood Hits	22	Target Neighborhood Hits	264	Shared Neighborhood Hits	5
SwissProt Accessions	P62046	Gene names	Lrch1, Chdc1, Kiaa1016
Domain Architecture
Description	Leucine-rich repeats and calponin homology domain-containing protein 1 (Calponin homology domain-containing protein 1).

MATR3_MOUSE
NC score	0.012248 (rank : 16)	θ value	6.88961 (rank : 18)
Query Neighborhood Hits	22	Target Neighborhood Hits	321	Shared Neighborhood Hits	2
SwissProt Accessions	Q8K310	Gene names	Matr3
Domain Architecture	No domain graphic available
Description	Matrin-3.

CABP4_HUMAN
NC score	0.011589 (rank : 17)	θ value	8.99809 (rank : 19)
Query Neighborhood Hits	22	Target Neighborhood Hits	250	Shared Neighborhood Hits	3
SwissProt Accessions	P57796, Q8N4Z2, Q8WWY5	Gene names	CABP4
Domain Architecture
Description	Calcium-binding protein 4 (CaBP4).

PKNX2_HUMAN
NC score	0.011151 (rank : 18)	θ value	5.27518 (rank : 16)
Query Neighborhood Hits	22	Target Neighborhood Hits	133	Shared Neighborhood Hits	3
SwissProt Accessions	Q96KN3, Q63HL6, Q86XD1	Gene names	PKNOX2, PREP2
Domain Architecture
Description	Homeobox protein PKNOX2 (PBX/knotted homeobox 2) (Homeobox protein PREP-2).

SCN9A_HUMAN
NC score	0.010774 (rank : 19)	θ value	1.38821 (rank : 8)
Query Neighborhood Hits	22	Target Neighborhood Hits	157	Shared Neighborhood Hits	2
SwissProt Accessions	Q15858, Q6B4R9, Q6B4S0, Q6B4S1, Q70HX1, Q70HX2, Q8WTU1, Q8WWN4	Gene names	SCN9A, NENA, PN1
Domain Architecture	No domain graphic available
Description	Sodium channel protein type 9 subunit alpha (Sodium channel protein type IX subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.7) (Neuroendocrine sodium channel) (hNE-Na) (Peripheral sodium channel 1).

LRCH1_HUMAN
NC score	0.010215 (rank : 20)	θ value	8.99809 (rank : 21)
Query Neighborhood Hits	22	Target Neighborhood Hits	266	Shared Neighborhood Hits	5
SwissProt Accessions	Q9Y2L9, Q7Z5F6, Q7Z5F7	Gene names	LRCH1, CHDC1, KIAA1016
Domain Architecture
Description	Leucine-rich repeats and calponin homology domain-containing protein 1 (Calponin homology domain-containing protein 1) (Neuronal protein 81) (NP81).

TBX21_HUMAN
NC score	0.007953 (rank : 21)	θ value	5.27518 (rank : 17)
Query Neighborhood Hits	22	Target Neighborhood Hits	146	Shared Neighborhood Hits	2
SwissProt Accessions	Q9UL17	Gene names	TBX21, TBET, TBLYM
Domain Architecture
Description	T-box transcription factor TBX21 (T-box protein 21) (Transcription factor TBLYM) (T-cell-specific T-box transcription factor T-bet).

NIN_HUMAN
NC score	0.007293 (rank : 22)	θ value	2.36792 (rank : 10)
Query Neighborhood Hits	22	Target Neighborhood Hits	1416	Shared Neighborhood Hits	3
SwissProt Accessions	Q8N4C6, Q6P0P6, Q9BWU6, Q9C012, Q9C013, Q9C014, Q9H5I6, Q9HAT7, Q9HBY5, Q9HCK7, Q9UH61	Gene names	NIN, KIAA1565
Domain Architecture	No domain graphic available
Description	Ninein (hNinein) (Glycogen synthase kinase 3 beta-interacting protein) (GSK3B-interacting protein).