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Network neighborhood for query Sequence : APHC_HUMAN

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APHC_HUMAN
SwissProt Accessions	Q9NUN7	Gene names	PHCA, APHC
Domain Architecture
Description	Alkaline phytoceramidase (EC 3.5.1.-) (aPHC) (Alkaline ceramidase) (Alkaline dihydroceramidase SB89).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

APHC_HUMAN
θ value	2.04462e-161 (rank : 1)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	10	Target Neighborhood Hits	10	Shared Neighborhood Hits	10
SwissProt Accessions	Q9NUN7	Gene names	PHCA, APHC
Domain Architecture
Description	Alkaline phytoceramidase (EC 3.5.1.-) (aPHC) (Alkaline ceramidase) (Alkaline dihydroceramidase SB89).

APHC_MOUSE
θ value	4.42207e-148 (rank : 2)	NC score	0.997888 (rank : 2)
Query Neighborhood Hits	10	Target Neighborhood Hits	8	Shared Neighborhood Hits	6
SwissProt Accessions	Q9D099, Q542R2, Q9D0X4, Q9D3J4	Gene names	Phca, Aphc
Domain Architecture
Description	Alkaline phytoceramidase (EC 3.5.1.-) (aPHC) (Alkaline ceramidase).

ASA3L_HUMAN
θ value	6.41864e-14 (rank : 3)	NC score	0.624842 (rank : 3)
Query Neighborhood Hits	10	Target Neighborhood Hits	9	Shared Neighborhood Hits	6
SwissProt Accessions	Q5QJU3, Q569G5, Q5VZR7, Q71RD2	Gene names	ASAH3L, ACER2
Domain Architecture	No domain graphic available
Description	Alkaline ceramidase 2 (EC 3.5.1.23) (AlkCDase 2) (Acylsphingosine deacylase 3-like) (N-acylsphingosine amidohydrolase 3-like).

ASA3L_MOUSE
θ value	1.42992e-13 (rank : 4)	NC score	0.623817 (rank : 4)
Query Neighborhood Hits	10	Target Neighborhood Hits	10	Shared Neighborhood Hits	6
SwissProt Accessions	Q8VD53, Q6PB92, Q8BUG3	Gene names	Asah3l, Acer2
Domain Architecture	No domain graphic available
Description	Alkaline ceramidase 2 (EC 3.5.1.23) (AlkCDase 2) (maCER2) (Acylsphingosine deacylase 3-like) (N-acylsphingosine amidohydrolase 3-like) (Cancer related gene-liver 1) (CRG-L1).

ASAH3_HUMAN
θ value	3.29651e-10 (rank : 5)	NC score	0.587737 (rank : 6)
Query Neighborhood Hits	10	Target Neighborhood Hits	12	Shared Neighborhood Hits	6
SwissProt Accessions	Q8TDN7	Gene names	ASAH3, ACER1
Domain Architecture	No domain graphic available
Description	Alkaline ceramidase 1 (EC 3.5.1.23) (Alkaline CDase-1) (AlkCDase 1) (Acylsphingosine deacylase 3) (N-acylsphingosine amidohydrolase 3).

ASAH3_MOUSE
θ value	5.62301e-10 (rank : 6)	NC score	0.588451 (rank : 5)
Query Neighborhood Hits	10	Target Neighborhood Hits	13	Shared Neighborhood Hits	6
SwissProt Accessions	Q8R4X1	Gene names	Asah3, Acer1
Domain Architecture	No domain graphic available
Description	Alkaline ceramidase 1 (EC 3.5.1.23) (Alkaline CDase-1) (AlkCDase 1) (maCER1) (Acylsphingosine deacylase 3) (N-acylsphingosine amidohydrolase 3).

ITPR3_MOUSE
θ value	0.62314 (rank : 7)	NC score	0.034306 (rank : 7)
Query Neighborhood Hits	10	Target Neighborhood Hits	105	Shared Neighborhood Hits	3
SwissProt Accessions	P70227, Q5DWM4, Q8CED5, Q91Z08	Gene names	Itpr3
Domain Architecture	No domain graphic available
Description	Inositol 1,4,5-trisphosphate receptor type 3 (Type 3 inositol 1,4,5- trisphosphate receptor) (Type 3 InsP3 receptor) (IP3 receptor isoform 3) (InsP3R3).

CAC1C_HUMAN
θ value	4.03905 (rank : 8)	NC score	0.009186 (rank : 9)
Query Neighborhood Hits	10	Target Neighborhood Hits	158	Shared Neighborhood Hits	2
SwissProt Accessions	Q13936, Q13917, Q13918, Q13919, Q13920, Q13921, Q13922, Q13923, Q13924, Q13925, Q13926, Q13927, Q13928, Q13929, Q13930, Q13932, Q13933, Q14743, Q14744, Q15877, Q99025, Q99241, Q99875	Gene names	CACNA1C, CACH2, CACN2, CACNL1A1, CCHL1A1
Domain Architecture
Description	Voltage-dependent L-type calcium channel subunit alpha-1C (Voltage- gated calcium channel subunit alpha Cav1.2) (Calcium channel, L type, alpha-1 polypeptide, isoform 1, cardiac muscle).

ITPR3_HUMAN
θ value	4.03905 (rank : 9)	NC score	0.029786 (rank : 8)
Query Neighborhood Hits	10	Target Neighborhood Hits	114	Shared Neighborhood Hits	3
SwissProt Accessions	Q14573, Q14649	Gene names	ITPR3
Domain Architecture
Description	Inositol 1,4,5-trisphosphate receptor type 3 (Type 3 inositol 1,4,5- trisphosphate receptor) (Type 3 InsP3 receptor) (IP3 receptor isoform 3) (InsP3R3).

OR7D2_HUMAN
θ value	6.88961 (rank : 10)	NC score	0.000045 (rank : 10)
Query Neighborhood Hits	10	Target Neighborhood Hits	809	Shared Neighborhood Hits	2
SwissProt Accessions	Q96RA2, Q8N133	Gene names	OR7D2
Domain Architecture
Description	Olfactory receptor 7D2 (Olfactory receptor 19-4) (OR19-4) (HTPCRH03).

Hits sorted by NC score

APHC_HUMAN
NC score	0.999962 (rank : 1)	θ value	2.04462e-161 (rank : 1)
Query Neighborhood Hits	10	Target Neighborhood Hits	10	Shared Neighborhood Hits	10
SwissProt Accessions	Q9NUN7	Gene names	PHCA, APHC
Domain Architecture
Description	Alkaline phytoceramidase (EC 3.5.1.-) (aPHC) (Alkaline ceramidase) (Alkaline dihydroceramidase SB89).

APHC_MOUSE
NC score	0.997888 (rank : 2)	θ value	4.42207e-148 (rank : 2)
Query Neighborhood Hits	10	Target Neighborhood Hits	8	Shared Neighborhood Hits	6
SwissProt Accessions	Q9D099, Q542R2, Q9D0X4, Q9D3J4	Gene names	Phca, Aphc
Domain Architecture
Description	Alkaline phytoceramidase (EC 3.5.1.-) (aPHC) (Alkaline ceramidase).

ASA3L_HUMAN
NC score	0.624842 (rank : 3)	θ value	6.41864e-14 (rank : 3)
Query Neighborhood Hits	10	Target Neighborhood Hits	9	Shared Neighborhood Hits	6
SwissProt Accessions	Q5QJU3, Q569G5, Q5VZR7, Q71RD2	Gene names	ASAH3L, ACER2
Domain Architecture	No domain graphic available
Description	Alkaline ceramidase 2 (EC 3.5.1.23) (AlkCDase 2) (Acylsphingosine deacylase 3-like) (N-acylsphingosine amidohydrolase 3-like).

ASA3L_MOUSE
NC score	0.623817 (rank : 4)	θ value	1.42992e-13 (rank : 4)
Query Neighborhood Hits	10	Target Neighborhood Hits	10	Shared Neighborhood Hits	6
SwissProt Accessions	Q8VD53, Q6PB92, Q8BUG3	Gene names	Asah3l, Acer2
Domain Architecture	No domain graphic available
Description	Alkaline ceramidase 2 (EC 3.5.1.23) (AlkCDase 2) (maCER2) (Acylsphingosine deacylase 3-like) (N-acylsphingosine amidohydrolase 3-like) (Cancer related gene-liver 1) (CRG-L1).

ASAH3_MOUSE
NC score	0.588451 (rank : 5)	θ value	5.62301e-10 (rank : 6)
Query Neighborhood Hits	10	Target Neighborhood Hits	13	Shared Neighborhood Hits	6
SwissProt Accessions	Q8R4X1	Gene names	Asah3, Acer1
Domain Architecture	No domain graphic available
Description	Alkaline ceramidase 1 (EC 3.5.1.23) (Alkaline CDase-1) (AlkCDase 1) (maCER1) (Acylsphingosine deacylase 3) (N-acylsphingosine amidohydrolase 3).

ASAH3_HUMAN
NC score	0.587737 (rank : 6)	θ value	3.29651e-10 (rank : 5)
Query Neighborhood Hits	10	Target Neighborhood Hits	12	Shared Neighborhood Hits	6
SwissProt Accessions	Q8TDN7	Gene names	ASAH3, ACER1
Domain Architecture	No domain graphic available
Description	Alkaline ceramidase 1 (EC 3.5.1.23) (Alkaline CDase-1) (AlkCDase 1) (Acylsphingosine deacylase 3) (N-acylsphingosine amidohydrolase 3).

ITPR3_MOUSE
NC score	0.034306 (rank : 7)	θ value	0.62314 (rank : 7)
Query Neighborhood Hits	10	Target Neighborhood Hits	105	Shared Neighborhood Hits	3
SwissProt Accessions	P70227, Q5DWM4, Q8CED5, Q91Z08	Gene names	Itpr3
Domain Architecture	No domain graphic available
Description	Inositol 1,4,5-trisphosphate receptor type 3 (Type 3 inositol 1,4,5- trisphosphate receptor) (Type 3 InsP3 receptor) (IP3 receptor isoform 3) (InsP3R3).

ITPR3_HUMAN
NC score	0.029786 (rank : 8)	θ value	4.03905 (rank : 9)
Query Neighborhood Hits	10	Target Neighborhood Hits	114	Shared Neighborhood Hits	3
SwissProt Accessions	Q14573, Q14649	Gene names	ITPR3
Domain Architecture
Description	Inositol 1,4,5-trisphosphate receptor type 3 (Type 3 inositol 1,4,5- trisphosphate receptor) (Type 3 InsP3 receptor) (IP3 receptor isoform 3) (InsP3R3).

CAC1C_HUMAN
NC score	0.009186 (rank : 9)	θ value	4.03905 (rank : 8)
Query Neighborhood Hits	10	Target Neighborhood Hits	158	Shared Neighborhood Hits	2
SwissProt Accessions	Q13936, Q13917, Q13918, Q13919, Q13920, Q13921, Q13922, Q13923, Q13924, Q13925, Q13926, Q13927, Q13928, Q13929, Q13930, Q13932, Q13933, Q14743, Q14744, Q15877, Q99025, Q99241, Q99875	Gene names	CACNA1C, CACH2, CACN2, CACNL1A1, CCHL1A1
Domain Architecture
Description	Voltage-dependent L-type calcium channel subunit alpha-1C (Voltage- gated calcium channel subunit alpha Cav1.2) (Calcium channel, L type, alpha-1 polypeptide, isoform 1, cardiac muscle).

OR7D2_HUMAN
NC score	0.000045 (rank : 10)	θ value	6.88961 (rank : 10)
Query Neighborhood Hits	10	Target Neighborhood Hits	809	Shared Neighborhood Hits	2
SwissProt Accessions	Q96RA2, Q8N133	Gene names	OR7D2
Domain Architecture
Description	Olfactory receptor 7D2 (Olfactory receptor 19-4) (OR19-4) (HTPCRH03).