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Network neighborhood for query Sequence : XPP1_MOUSE

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XPP1_MOUSE
SwissProt Accessions	Q6P1B1, Q91Y37	Gene names	Xpnpep1
Domain Architecture	No domain graphic available
Description	Xaa-Pro aminopeptidase 1 (EC 3.4.11.9) (X-Pro aminopeptidase 1) (X- prolyl aminopeptidase 1, soluble) (Cytosolic aminopeptidase P) (Soluble aminopeptidase P) (sAmp) (Aminoacylproline aminopeptidase).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

XPP1_HUMAN
θ value	0 (rank : 1)	NC score	0.998694 (rank : 2)
Query Neighborhood Hits	11	Target Neighborhood Hits	12	Shared Neighborhood Hits	10
SwissProt Accessions	Q9NQW7, O15250, Q53EX6, Q8N3Q0, Q96D23	Gene names	XPNPEP1, XPNPEPL
Domain Architecture	No domain graphic available
Description	Xaa-Pro aminopeptidase 1 (EC 3.4.11.9) (X-Pro aminopeptidase 1) (X- prolyl aminopeptidase 1, soluble) (Cytosolic aminopeptidase P) (Soluble aminopeptidase P) (sAmp) (Aminoacylproline aminopeptidase).

XPP1_MOUSE
θ value	0 (rank : 2)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	11	Target Neighborhood Hits	11	Shared Neighborhood Hits	11
SwissProt Accessions	Q6P1B1, Q91Y37	Gene names	Xpnpep1
Domain Architecture	No domain graphic available
Description	Xaa-Pro aminopeptidase 1 (EC 3.4.11.9) (X-Pro aminopeptidase 1) (X- prolyl aminopeptidase 1, soluble) (Cytosolic aminopeptidase P) (Soluble aminopeptidase P) (sAmp) (Aminoacylproline aminopeptidase).

XPP2_HUMAN
θ value	1.86219e-138 (rank : 3)	NC score	0.961270 (rank : 3)
Query Neighborhood Hits	11	Target Neighborhood Hits	10	Shared Neighborhood Hits	5
SwissProt Accessions	O43895, O75994	Gene names	XPNPEP2
Domain Architecture
Description	Xaa-Pro aminopeptidase 2 precursor (EC 3.4.11.9) (X-Pro aminopeptidase 2) (Membrane-bound aminopeptidase P) (Membrane-bound APP) (Membrane- bound AmP) (mAmP) (Aminoacylproline aminopeptidase).

PEPD_HUMAN
θ value	3.19293e-05 (rank : 4)	NC score	0.283999 (rank : 4)
Query Neighborhood Hits	11	Target Neighborhood Hits	14	Shared Neighborhood Hits	5
SwissProt Accessions	P12955, Q8TBN9, Q9BT75	Gene names	PEPD, PRD
Domain Architecture
Description	Xaa-Pro dipeptidase (EC 3.4.13.9) (X-Pro dipeptidase) (Proline dipeptidase) (Prolidase) (Imidodipeptidase).

PEPD_MOUSE
θ value	0.000121331 (rank : 5)	NC score	0.262160 (rank : 5)
Query Neighborhood Hits	11	Target Neighborhood Hits	9	Shared Neighborhood Hits	5
SwissProt Accessions	Q11136, P97735, Q3TH86, Q9CWK4	Gene names	Pepd, Pep4
Domain Architecture
Description	Xaa-Pro dipeptidase (EC 3.4.13.9) (X-Pro dipeptidase) (Proline dipeptidase) (Prolidase) (Imidodipeptidase) (Peptidase 4).

RIOK3_HUMAN
θ value	4.03905 (rank : 6)	NC score	0.052227 (rank : 6)
Query Neighborhood Hits	11	Target Neighborhood Hits	13	Shared Neighborhood Hits	3
SwissProt Accessions	O14730, Q8IXN9	Gene names	RIOK3, SUDD
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase RIO3 (EC 2.7.11.1) (RIO kinase 3) (sudD homolog).

AMPM2_HUMAN
θ value	6.88961 (rank : 7)	NC score	0.031311 (rank : 8)
Query Neighborhood Hits	11	Target Neighborhood Hits	17	Shared Neighborhood Hits	4
SwissProt Accessions	P50579	Gene names	METAP2, MNPEP, P67EIF2
Domain Architecture
Description	Methionine aminopeptidase 2 (EC 3.4.11.18) (MetAP 2) (Peptidase M 2) (Initiation factor 2-associated 67 kDa glycoprotein) (p67) (p67eIF2).

AMPM2_MOUSE
θ value	6.88961 (rank : 8)	NC score	0.031370 (rank : 7)
Query Neighborhood Hits	11	Target Neighborhood Hits	19	Shared Neighborhood Hits	4
SwissProt Accessions	O08663	Gene names	Metap2, Mnpep, P67eif2
Domain Architecture
Description	Methionine aminopeptidase 2 (EC 3.4.11.18) (MetAP 2) (Peptidase M 2) (Initiation factor 2-associated 67 kDa glycoprotein) (p67) (p67eIF2).

MSPD2_MOUSE
θ value	6.88961 (rank : 9)	NC score	0.015288 (rank : 9)
Query Neighborhood Hits	11	Target Neighborhood Hits	50	Shared Neighborhood Hits	2
SwissProt Accessions	Q9CWP6, Q8BYF8, Q8BZB6, Q8C0G1, Q8R0T7	Gene names	Mospd2
Domain Architecture	No domain graphic available
Description	Motile sperm domain-containing protein 2.

CAD15_HUMAN
θ value	8.99809 (rank : 10)	NC score	0.004007 (rank : 11)
Query Neighborhood Hits	11	Target Neighborhood Hits	173	Shared Neighborhood Hits	3
SwissProt Accessions	P55291	Gene names	CDH15, CDH14, CDH3
Domain Architecture
Description	Cadherin-15 precursor (Muscle-cadherin) (M-cadherin) (Cadherin-14).

TAU_MOUSE
θ value	8.99809 (rank : 11)	NC score	0.013506 (rank : 10)
Query Neighborhood Hits	11	Target Neighborhood Hits	502	Shared Neighborhood Hits	3
SwissProt Accessions	P10637, P10638, Q60684, Q60685, Q60686, Q62286	Gene names	Mapt, Mtapt, Tau
Domain Architecture
Description	Microtubule-associated protein tau (Neurofibrillary tangle protein) (Paired helical filament-tau) (PHF-tau).

Hits sorted by NC score

XPP1_MOUSE
NC score	0.999962 (rank : 1)	θ value	0 (rank : 2)
Query Neighborhood Hits	11	Target Neighborhood Hits	11	Shared Neighborhood Hits	11
SwissProt Accessions	Q6P1B1, Q91Y37	Gene names	Xpnpep1
Domain Architecture	No domain graphic available
Description	Xaa-Pro aminopeptidase 1 (EC 3.4.11.9) (X-Pro aminopeptidase 1) (X- prolyl aminopeptidase 1, soluble) (Cytosolic aminopeptidase P) (Soluble aminopeptidase P) (sAmp) (Aminoacylproline aminopeptidase).

XPP1_HUMAN
NC score	0.998694 (rank : 2)	θ value	0 (rank : 1)
Query Neighborhood Hits	11	Target Neighborhood Hits	12	Shared Neighborhood Hits	10
SwissProt Accessions	Q9NQW7, O15250, Q53EX6, Q8N3Q0, Q96D23	Gene names	XPNPEP1, XPNPEPL
Domain Architecture	No domain graphic available
Description	Xaa-Pro aminopeptidase 1 (EC 3.4.11.9) (X-Pro aminopeptidase 1) (X- prolyl aminopeptidase 1, soluble) (Cytosolic aminopeptidase P) (Soluble aminopeptidase P) (sAmp) (Aminoacylproline aminopeptidase).

XPP2_HUMAN
NC score	0.961270 (rank : 3)	θ value	1.86219e-138 (rank : 3)
Query Neighborhood Hits	11	Target Neighborhood Hits	10	Shared Neighborhood Hits	5
SwissProt Accessions	O43895, O75994	Gene names	XPNPEP2
Domain Architecture
Description	Xaa-Pro aminopeptidase 2 precursor (EC 3.4.11.9) (X-Pro aminopeptidase 2) (Membrane-bound aminopeptidase P) (Membrane-bound APP) (Membrane- bound AmP) (mAmP) (Aminoacylproline aminopeptidase).

PEPD_HUMAN
NC score	0.283999 (rank : 4)	θ value	3.19293e-05 (rank : 4)
Query Neighborhood Hits	11	Target Neighborhood Hits	14	Shared Neighborhood Hits	5
SwissProt Accessions	P12955, Q8TBN9, Q9BT75	Gene names	PEPD, PRD
Domain Architecture
Description	Xaa-Pro dipeptidase (EC 3.4.13.9) (X-Pro dipeptidase) (Proline dipeptidase) (Prolidase) (Imidodipeptidase).

PEPD_MOUSE
NC score	0.262160 (rank : 5)	θ value	0.000121331 (rank : 5)
Query Neighborhood Hits	11	Target Neighborhood Hits	9	Shared Neighborhood Hits	5
SwissProt Accessions	Q11136, P97735, Q3TH86, Q9CWK4	Gene names	Pepd, Pep4
Domain Architecture
Description	Xaa-Pro dipeptidase (EC 3.4.13.9) (X-Pro dipeptidase) (Proline dipeptidase) (Prolidase) (Imidodipeptidase) (Peptidase 4).

RIOK3_HUMAN
NC score	0.052227 (rank : 6)	θ value	4.03905 (rank : 6)
Query Neighborhood Hits	11	Target Neighborhood Hits	13	Shared Neighborhood Hits	3
SwissProt Accessions	O14730, Q8IXN9	Gene names	RIOK3, SUDD
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase RIO3 (EC 2.7.11.1) (RIO kinase 3) (sudD homolog).

AMPM2_MOUSE
NC score	0.031370 (rank : 7)	θ value	6.88961 (rank : 8)
Query Neighborhood Hits	11	Target Neighborhood Hits	19	Shared Neighborhood Hits	4
SwissProt Accessions	O08663	Gene names	Metap2, Mnpep, P67eif2
Domain Architecture
Description	Methionine aminopeptidase 2 (EC 3.4.11.18) (MetAP 2) (Peptidase M 2) (Initiation factor 2-associated 67 kDa glycoprotein) (p67) (p67eIF2).

AMPM2_HUMAN
NC score	0.031311 (rank : 8)	θ value	6.88961 (rank : 7)
Query Neighborhood Hits	11	Target Neighborhood Hits	17	Shared Neighborhood Hits	4
SwissProt Accessions	P50579	Gene names	METAP2, MNPEP, P67EIF2
Domain Architecture
Description	Methionine aminopeptidase 2 (EC 3.4.11.18) (MetAP 2) (Peptidase M 2) (Initiation factor 2-associated 67 kDa glycoprotein) (p67) (p67eIF2).

MSPD2_MOUSE
NC score	0.015288 (rank : 9)	θ value	6.88961 (rank : 9)
Query Neighborhood Hits	11	Target Neighborhood Hits	50	Shared Neighborhood Hits	2
SwissProt Accessions	Q9CWP6, Q8BYF8, Q8BZB6, Q8C0G1, Q8R0T7	Gene names	Mospd2
Domain Architecture	No domain graphic available
Description	Motile sperm domain-containing protein 2.

TAU_MOUSE
NC score	0.013506 (rank : 10)	θ value	8.99809 (rank : 11)
Query Neighborhood Hits	11	Target Neighborhood Hits	502	Shared Neighborhood Hits	3
SwissProt Accessions	P10637, P10638, Q60684, Q60685, Q60686, Q62286	Gene names	Mapt, Mtapt, Tau
Domain Architecture
Description	Microtubule-associated protein tau (Neurofibrillary tangle protein) (Paired helical filament-tau) (PHF-tau).

CAD15_HUMAN
NC score	0.004007 (rank : 11)	θ value	8.99809 (rank : 10)
Query Neighborhood Hits	11	Target Neighborhood Hits	173	Shared Neighborhood Hits	3
SwissProt Accessions	P55291	Gene names	CDH15, CDH14, CDH3
Domain Architecture
Description	Cadherin-15 precursor (Muscle-cadherin) (M-cadherin) (Cadherin-14).