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Network neighborhood for query Sequence : SIRT3_HUMAN

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SIRT3_HUMAN
SwissProt Accessions	Q9NTG7, Q9Y6E8	Gene names	SIRT3, SIR2L3
Domain Architecture
Description	NAD-dependent deacetylase sirtuin-3, mitochondrial precursor (EC 3.5.1.-) (SIR2-like protein 3) (hSIRT3).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

SIRT3_HUMAN
θ value	7.22167e-183 (rank : 1)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	18	Target Neighborhood Hits	18	Shared Neighborhood Hits	18
SwissProt Accessions	Q9NTG7, Q9Y6E8	Gene names	SIRT3, SIR2L3
Domain Architecture
Description	NAD-dependent deacetylase sirtuin-3, mitochondrial precursor (EC 3.5.1.-) (SIR2-like protein 3) (hSIRT3).

SIRT3_MOUSE
θ value	8.69046e-120 (rank : 2)	NC score	0.997960 (rank : 2)
Query Neighborhood Hits	18	Target Neighborhood Hits	18	Shared Neighborhood Hits	14
SwissProt Accessions	Q8R104, Q9EPA8	Gene names	Sirt3, Sir2l3
Domain Architecture
Description	NAD-dependent deacetylase sirtuin-3 (EC 3.5.1.-) (SIR2-like protein 3) (mSIR2L3).

SIRT2_HUMAN
θ value	5.33382e-77 (rank : 3)	NC score	0.972464 (rank : 4)
Query Neighborhood Hits	18	Target Neighborhood Hits	16	Shared Neighborhood Hits	14
SwissProt Accessions	Q8IXJ6, O95889, Q924Y7, Q9P0G8, Q9UNT0, Q9Y6E9	Gene names	SIRT2, SIR2L, SIR2L2
Domain Architecture
Description	NAD-dependent deacetylase sirtuin-2 (EC 3.5.1.-) (SIR2-like) (SIR2- like protein 2).

SIRT2_MOUSE
θ value	6.96618e-77 (rank : 4)	NC score	0.974028 (rank : 3)
Query Neighborhood Hits	18	Target Neighborhood Hits	15	Shared Neighborhood Hits	14
SwissProt Accessions	Q8VDQ8, Q9CXS5, Q9EQ18, Q9ERJ9	Gene names	Sirt2, Sir2l2
Domain Architecture
Description	NAD-dependent deacetylase sirtuin-2 (EC 3.5.1.-) (SIR2-like protein 2) (mSIR2L2).

SIRT1_HUMAN
θ value	1.61718e-49 (rank : 5)	NC score	0.900204 (rank : 6)
Query Neighborhood Hits	18	Target Neighborhood Hits	44	Shared Neighborhood Hits	14
SwissProt Accessions	Q96EB6, Q2XNF6, Q5JVQ0, Q9GZR9, Q9Y6F0	Gene names	SIRT1, SIR2L1
Domain Architecture
Description	NAD-dependent deacetylase sirtuin-1 (EC 3.5.1.-) (hSIRT1) (hSIR2) (SIR2-like protein 1).

SIRT1_MOUSE
θ value	2.75849e-49 (rank : 6)	NC score	0.903688 (rank : 5)
Query Neighborhood Hits	18	Target Neighborhood Hits	50	Shared Neighborhood Hits	14
SwissProt Accessions	Q923E4, Q9QXG8	Gene names	Sirt1, Sir2l1
Domain Architecture
Description	NAD-dependent deacetylase sirtuin-1 (EC 3.5.1.-) (SIR2alpha) (mSIR2a) (Sir2) (SIR2-like protein 1).

SIRT4_HUMAN
θ value	1.80466e-16 (rank : 7)	NC score	0.745325 (rank : 8)
Query Neighborhood Hits	18	Target Neighborhood Hits	14	Shared Neighborhood Hits	14
SwissProt Accessions	Q9Y6E7, O43346	Gene names	SIRT4, SIR2L4
Domain Architecture
Description	NAD-dependent deacetylase sirtuin-4 (EC 3.5.1.-) (SIR2-like protein 4).

SIRT5_MOUSE
θ value	2.35696e-16 (rank : 8)	NC score	0.750454 (rank : 7)
Query Neighborhood Hits	18	Target Neighborhood Hits	19	Shared Neighborhood Hits	14
SwissProt Accessions	Q8K2C6	Gene names	Sirt5, Sir2l5
Domain Architecture
Description	NAD-dependent deacetylase sirtuin-5 (EC 3.5.1.-) (SIR2-like protein 5).

SIRT5_HUMAN
θ value	3.07829e-16 (rank : 9)	NC score	0.743123 (rank : 9)
Query Neighborhood Hits	18	Target Neighborhood Hits	17	Shared Neighborhood Hits	14
SwissProt Accessions	Q9NXA8, Q9Y6E6	Gene names	SIRT5, SIR2L5
Domain Architecture
Description	NAD-dependent deacetylase sirtuin-5 (EC 3.5.1.-) (SIR2-like protein 5).

SIRT6_MOUSE
θ value	3.07829e-16 (rank : 10)	NC score	0.704796 (rank : 12)
Query Neighborhood Hits	18	Target Neighborhood Hits	18	Shared Neighborhood Hits	14
SwissProt Accessions	P59941	Gene names	Sirt6, Sir2l6
Domain Architecture
Description	Mono-ADP-ribosyltransferase sirtuin-6 (EC 2.4.2.31) (SIR2-like protein 6).

SIRT6_HUMAN
θ value	1.16975e-15 (rank : 11)	NC score	0.713162 (rank : 11)
Query Neighborhood Hits	18	Target Neighborhood Hits	29	Shared Neighborhood Hits	14
SwissProt Accessions	Q8N6T7, O75291, Q6IAF5, Q6PK99, Q8NCD2, Q9BSI5, Q9BWP3, Q9NRC7, Q9UQD1	Gene names	SIRT6, SIR2L6
Domain Architecture
Description	Mono-ADP-ribosyltransferase sirtuin-6 (EC 2.4.2.31) (SIR2-like protein 6).

SIRT4_MOUSE
θ value	9.90251e-15 (rank : 12)	NC score	0.736695 (rank : 10)
Query Neighborhood Hits	18	Target Neighborhood Hits	16	Shared Neighborhood Hits	14
SwissProt Accessions	Q8R216	Gene names	Sirt4, Sir2l4
Domain Architecture
Description	NAD-dependent deacetylase sirtuin-4 (EC 3.5.1.-) (SIR2-like protein 4).

SIRT7_MOUSE
θ value	1.74796e-11 (rank : 13)	NC score	0.632776 (rank : 13)
Query Neighborhood Hits	18	Target Neighborhood Hits	44	Shared Neighborhood Hits	14
SwissProt Accessions	Q8BKJ9, Q6X7B7, Q8QZZ5	Gene names	Sirt7, Sir2l7
Domain Architecture
Description	NAD-dependent deacetylase sirtuin-7 (EC 3.5.1.-) (SIR2-like protein 7).

SIRT7_HUMAN
θ value	8.67504e-11 (rank : 14)	NC score	0.626980 (rank : 14)
Query Neighborhood Hits	18	Target Neighborhood Hits	29	Shared Neighborhood Hits	14
SwissProt Accessions	Q9NRC8, Q3MIK4, Q9NSZ6, Q9NUS6	Gene names	SIRT7, SIR2L7
Domain Architecture
Description	NAD-dependent deacetylase sirtuin-7 (EC 3.5.1.-) (SIR2-like protein 7).

EYA1_MOUSE
θ value	3.0926 (rank : 15)	NC score	0.011224 (rank : 16)
Query Neighborhood Hits	18	Target Neighborhood Hits	108	Shared Neighborhood Hits	2
SwissProt Accessions	P97767, O08818	Gene names	Eya1
Domain Architecture
Description	Eyes absent homolog 1 (EC 3.1.3.48).

BGAL_HUMAN
θ value	6.88961 (rank : 16)	NC score	0.011288 (rank : 15)
Query Neighborhood Hits	18	Target Neighborhood Hits	6	Shared Neighborhood Hits	2
SwissProt Accessions	P16278	Gene names	GLB1
Domain Architecture
Description	Beta-galactosidase precursor (EC 3.2.1.23) (Lactase) (Acid beta- galactosidase).

EVX1_HUMAN
θ value	6.88961 (rank : 17)	NC score	0.002787 (rank : 18)
Query Neighborhood Hits	18	Target Neighborhood Hits	349	Shared Neighborhood Hits	2
SwissProt Accessions	P49640	Gene names	EVX1
Domain Architecture
Description	Homeobox even-skipped homolog protein 1 (EVX-1).

Hits sorted by NC score

SIRT3_HUMAN
NC score	0.999962 (rank : 1)	θ value	7.22167e-183 (rank : 1)
Query Neighborhood Hits	18	Target Neighborhood Hits	18	Shared Neighborhood Hits	18
SwissProt Accessions	Q9NTG7, Q9Y6E8	Gene names	SIRT3, SIR2L3
Domain Architecture
Description	NAD-dependent deacetylase sirtuin-3, mitochondrial precursor (EC 3.5.1.-) (SIR2-like protein 3) (hSIRT3).

SIRT3_MOUSE
NC score	0.997960 (rank : 2)	θ value	8.69046e-120 (rank : 2)
Query Neighborhood Hits	18	Target Neighborhood Hits	18	Shared Neighborhood Hits	14
SwissProt Accessions	Q8R104, Q9EPA8	Gene names	Sirt3, Sir2l3
Domain Architecture
Description	NAD-dependent deacetylase sirtuin-3 (EC 3.5.1.-) (SIR2-like protein 3) (mSIR2L3).

SIRT2_MOUSE
NC score	0.974028 (rank : 3)	θ value	6.96618e-77 (rank : 4)
Query Neighborhood Hits	18	Target Neighborhood Hits	15	Shared Neighborhood Hits	14
SwissProt Accessions	Q8VDQ8, Q9CXS5, Q9EQ18, Q9ERJ9	Gene names	Sirt2, Sir2l2
Domain Architecture
Description	NAD-dependent deacetylase sirtuin-2 (EC 3.5.1.-) (SIR2-like protein 2) (mSIR2L2).

SIRT2_HUMAN
NC score	0.972464 (rank : 4)	θ value	5.33382e-77 (rank : 3)
Query Neighborhood Hits	18	Target Neighborhood Hits	16	Shared Neighborhood Hits	14
SwissProt Accessions	Q8IXJ6, O95889, Q924Y7, Q9P0G8, Q9UNT0, Q9Y6E9	Gene names	SIRT2, SIR2L, SIR2L2
Domain Architecture
Description	NAD-dependent deacetylase sirtuin-2 (EC 3.5.1.-) (SIR2-like) (SIR2- like protein 2).

SIRT1_MOUSE
NC score	0.903688 (rank : 5)	θ value	2.75849e-49 (rank : 6)
Query Neighborhood Hits	18	Target Neighborhood Hits	50	Shared Neighborhood Hits	14
SwissProt Accessions	Q923E4, Q9QXG8	Gene names	Sirt1, Sir2l1
Domain Architecture
Description	NAD-dependent deacetylase sirtuin-1 (EC 3.5.1.-) (SIR2alpha) (mSIR2a) (Sir2) (SIR2-like protein 1).

SIRT1_HUMAN
NC score	0.900204 (rank : 6)	θ value	1.61718e-49 (rank : 5)
Query Neighborhood Hits	18	Target Neighborhood Hits	44	Shared Neighborhood Hits	14
SwissProt Accessions	Q96EB6, Q2XNF6, Q5JVQ0, Q9GZR9, Q9Y6F0	Gene names	SIRT1, SIR2L1
Domain Architecture
Description	NAD-dependent deacetylase sirtuin-1 (EC 3.5.1.-) (hSIRT1) (hSIR2) (SIR2-like protein 1).

SIRT5_MOUSE
NC score	0.750454 (rank : 7)	θ value	2.35696e-16 (rank : 8)
Query Neighborhood Hits	18	Target Neighborhood Hits	19	Shared Neighborhood Hits	14
SwissProt Accessions	Q8K2C6	Gene names	Sirt5, Sir2l5
Domain Architecture
Description	NAD-dependent deacetylase sirtuin-5 (EC 3.5.1.-) (SIR2-like protein 5).

SIRT4_HUMAN
NC score	0.745325 (rank : 8)	θ value	1.80466e-16 (rank : 7)
Query Neighborhood Hits	18	Target Neighborhood Hits	14	Shared Neighborhood Hits	14
SwissProt Accessions	Q9Y6E7, O43346	Gene names	SIRT4, SIR2L4
Domain Architecture
Description	NAD-dependent deacetylase sirtuin-4 (EC 3.5.1.-) (SIR2-like protein 4).

SIRT5_HUMAN
NC score	0.743123 (rank : 9)	θ value	3.07829e-16 (rank : 9)
Query Neighborhood Hits	18	Target Neighborhood Hits	17	Shared Neighborhood Hits	14
SwissProt Accessions	Q9NXA8, Q9Y6E6	Gene names	SIRT5, SIR2L5
Domain Architecture
Description	NAD-dependent deacetylase sirtuin-5 (EC 3.5.1.-) (SIR2-like protein 5).

SIRT4_MOUSE
NC score	0.736695 (rank : 10)	θ value	9.90251e-15 (rank : 12)
Query Neighborhood Hits	18	Target Neighborhood Hits	16	Shared Neighborhood Hits	14
SwissProt Accessions	Q8R216	Gene names	Sirt4, Sir2l4
Domain Architecture
Description	NAD-dependent deacetylase sirtuin-4 (EC 3.5.1.-) (SIR2-like protein 4).

SIRT6_HUMAN
NC score	0.713162 (rank : 11)	θ value	1.16975e-15 (rank : 11)
Query Neighborhood Hits	18	Target Neighborhood Hits	29	Shared Neighborhood Hits	14
SwissProt Accessions	Q8N6T7, O75291, Q6IAF5, Q6PK99, Q8NCD2, Q9BSI5, Q9BWP3, Q9NRC7, Q9UQD1	Gene names	SIRT6, SIR2L6
Domain Architecture
Description	Mono-ADP-ribosyltransferase sirtuin-6 (EC 2.4.2.31) (SIR2-like protein 6).

SIRT6_MOUSE
NC score	0.704796 (rank : 12)	θ value	3.07829e-16 (rank : 10)
Query Neighborhood Hits	18	Target Neighborhood Hits	18	Shared Neighborhood Hits	14
SwissProt Accessions	P59941	Gene names	Sirt6, Sir2l6
Domain Architecture
Description	Mono-ADP-ribosyltransferase sirtuin-6 (EC 2.4.2.31) (SIR2-like protein 6).

SIRT7_MOUSE
NC score	0.632776 (rank : 13)	θ value	1.74796e-11 (rank : 13)
Query Neighborhood Hits	18	Target Neighborhood Hits	44	Shared Neighborhood Hits	14
SwissProt Accessions	Q8BKJ9, Q6X7B7, Q8QZZ5	Gene names	Sirt7, Sir2l7
Domain Architecture
Description	NAD-dependent deacetylase sirtuin-7 (EC 3.5.1.-) (SIR2-like protein 7).

SIRT7_HUMAN
NC score	0.626980 (rank : 14)	θ value	8.67504e-11 (rank : 14)
Query Neighborhood Hits	18	Target Neighborhood Hits	29	Shared Neighborhood Hits	14
SwissProt Accessions	Q9NRC8, Q3MIK4, Q9NSZ6, Q9NUS6	Gene names	SIRT7, SIR2L7
Domain Architecture
Description	NAD-dependent deacetylase sirtuin-7 (EC 3.5.1.-) (SIR2-like protein 7).

BGAL_HUMAN
NC score	0.011288 (rank : 15)	θ value	6.88961 (rank : 16)
Query Neighborhood Hits	18	Target Neighborhood Hits	6	Shared Neighborhood Hits	2
SwissProt Accessions	P16278	Gene names	GLB1
Domain Architecture
Description	Beta-galactosidase precursor (EC 3.2.1.23) (Lactase) (Acid beta- galactosidase).

EYA1_MOUSE
NC score	0.011224 (rank : 16)	θ value	3.0926 (rank : 15)
Query Neighborhood Hits	18	Target Neighborhood Hits	108	Shared Neighborhood Hits	2
SwissProt Accessions	P97767, O08818	Gene names	Eya1
Domain Architecture
Description	Eyes absent homolog 1 (EC 3.1.3.48).

EVX1_HUMAN
NC score	0.002787 (rank : 18)	θ value	6.88961 (rank : 17)
Query Neighborhood Hits	18	Target Neighborhood Hits	349	Shared Neighborhood Hits	2
SwissProt Accessions	P49640	Gene names	EVX1
Domain Architecture
Description	Homeobox even-skipped homolog protein 1 (EVX-1).