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Network neighborhood for query Sequence : SIRT6_MOUSE

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SIRT6_MOUSE
SwissProt Accessions	P59941	Gene names	Sirt6, Sir2l6
Domain Architecture
Description	Mono-ADP-ribosyltransferase sirtuin-6 (EC 2.4.2.31) (SIR2-like protein 6).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

SIRT6_MOUSE
θ value	0 (rank : 1)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	18	Target Neighborhood Hits	18	Shared Neighborhood Hits	18
SwissProt Accessions	P59941	Gene names	Sirt6, Sir2l6
Domain Architecture
Description	Mono-ADP-ribosyltransferase sirtuin-6 (EC 2.4.2.31) (SIR2-like protein 6).

SIRT6_HUMAN
θ value	9.15662e-170 (rank : 2)	NC score	0.995022 (rank : 2)
Query Neighborhood Hits	18	Target Neighborhood Hits	29	Shared Neighborhood Hits	14
SwissProt Accessions	Q8N6T7, O75291, Q6IAF5, Q6PK99, Q8NCD2, Q9BSI5, Q9BWP3, Q9NRC7, Q9UQD1	Gene names	SIRT6, SIR2L6
Domain Architecture
Description	Mono-ADP-ribosyltransferase sirtuin-6 (EC 2.4.2.31) (SIR2-like protein 6).

SIRT7_MOUSE
θ value	2.26182e-43 (rank : 3)	NC score	0.883581 (rank : 4)
Query Neighborhood Hits	18	Target Neighborhood Hits	44	Shared Neighborhood Hits	14
SwissProt Accessions	Q8BKJ9, Q6X7B7, Q8QZZ5	Gene names	Sirt7, Sir2l7
Domain Architecture
Description	NAD-dependent deacetylase sirtuin-7 (EC 3.5.1.-) (SIR2-like protein 7).

SIRT7_HUMAN
θ value	1.91475e-42 (rank : 4)	NC score	0.886895 (rank : 3)
Query Neighborhood Hits	18	Target Neighborhood Hits	29	Shared Neighborhood Hits	14
SwissProt Accessions	Q9NRC8, Q3MIK4, Q9NSZ6, Q9NUS6	Gene names	SIRT7, SIR2L7
Domain Architecture
Description	NAD-dependent deacetylase sirtuin-7 (EC 3.5.1.-) (SIR2-like protein 7).

SIRT4_MOUSE
θ value	6.20254e-17 (rank : 5)	NC score	0.744564 (rank : 5)
Query Neighborhood Hits	18	Target Neighborhood Hits	16	Shared Neighborhood Hits	14
SwissProt Accessions	Q8R216	Gene names	Sirt4, Sir2l4
Domain Architecture
Description	NAD-dependent deacetylase sirtuin-4 (EC 3.5.1.-) (SIR2-like protein 4).

SIRT3_HUMAN
θ value	3.07829e-16 (rank : 6)	NC score	0.704796 (rank : 8)
Query Neighborhood Hits	18	Target Neighborhood Hits	18	Shared Neighborhood Hits	14
SwissProt Accessions	Q9NTG7, Q9Y6E8	Gene names	SIRT3, SIR2L3
Domain Architecture
Description	NAD-dependent deacetylase sirtuin-3, mitochondrial precursor (EC 3.5.1.-) (SIR2-like protein 3) (hSIRT3).

SIRT4_HUMAN
θ value	5.25075e-16 (rank : 7)	NC score	0.743735 (rank : 6)
Query Neighborhood Hits	18	Target Neighborhood Hits	14	Shared Neighborhood Hits	14
SwissProt Accessions	Q9Y6E7, O43346	Gene names	SIRT4, SIR2L4
Domain Architecture
Description	NAD-dependent deacetylase sirtuin-4 (EC 3.5.1.-) (SIR2-like protein 4).

SIRT3_MOUSE
θ value	8.95645e-16 (rank : 8)	NC score	0.708987 (rank : 7)
Query Neighborhood Hits	18	Target Neighborhood Hits	18	Shared Neighborhood Hits	14
SwissProt Accessions	Q8R104, Q9EPA8	Gene names	Sirt3, Sir2l3
Domain Architecture
Description	NAD-dependent deacetylase sirtuin-3 (EC 3.5.1.-) (SIR2-like protein 3) (mSIR2L3).

SIRT2_MOUSE
θ value	2.69671e-12 (rank : 9)	NC score	0.670883 (rank : 9)
Query Neighborhood Hits	18	Target Neighborhood Hits	15	Shared Neighborhood Hits	14
SwissProt Accessions	Q8VDQ8, Q9CXS5, Q9EQ18, Q9ERJ9	Gene names	Sirt2, Sir2l2
Domain Architecture
Description	NAD-dependent deacetylase sirtuin-2 (EC 3.5.1.-) (SIR2-like protein 2) (mSIR2L2).

SIRT2_HUMAN
θ value	1.133e-10 (rank : 10)	NC score	0.655523 (rank : 10)
Query Neighborhood Hits	18	Target Neighborhood Hits	16	Shared Neighborhood Hits	14
SwissProt Accessions	Q8IXJ6, O95889, Q924Y7, Q9P0G8, Q9UNT0, Q9Y6E9	Gene names	SIRT2, SIR2L, SIR2L2
Domain Architecture
Description	NAD-dependent deacetylase sirtuin-2 (EC 3.5.1.-) (SIR2-like) (SIR2- like protein 2).

SIRT1_MOUSE
θ value	2.52405e-10 (rank : 11)	NC score	0.603922 (rank : 13)
Query Neighborhood Hits	18	Target Neighborhood Hits	50	Shared Neighborhood Hits	14
SwissProt Accessions	Q923E4, Q9QXG8	Gene names	Sirt1, Sir2l1
Domain Architecture
Description	NAD-dependent deacetylase sirtuin-1 (EC 3.5.1.-) (SIR2alpha) (mSIR2a) (Sir2) (SIR2-like protein 1).

SIRT1_HUMAN
θ value	9.59137e-10 (rank : 12)	NC score	0.599351 (rank : 14)
Query Neighborhood Hits	18	Target Neighborhood Hits	44	Shared Neighborhood Hits	14
SwissProt Accessions	Q96EB6, Q2XNF6, Q5JVQ0, Q9GZR9, Q9Y6F0	Gene names	SIRT1, SIR2L1
Domain Architecture
Description	NAD-dependent deacetylase sirtuin-1 (EC 3.5.1.-) (hSIRT1) (hSIR2) (SIR2-like protein 1).

SIRT5_MOUSE
θ value	4.76016e-09 (rank : 13)	NC score	0.634091 (rank : 11)
Query Neighborhood Hits	18	Target Neighborhood Hits	19	Shared Neighborhood Hits	14
SwissProt Accessions	Q8K2C6	Gene names	Sirt5, Sir2l5
Domain Architecture
Description	NAD-dependent deacetylase sirtuin-5 (EC 3.5.1.-) (SIR2-like protein 5).

SIRT5_HUMAN
θ value	6.87365e-08 (rank : 14)	NC score	0.622658 (rank : 12)
Query Neighborhood Hits	18	Target Neighborhood Hits	17	Shared Neighborhood Hits	14
SwissProt Accessions	Q9NXA8, Q9Y6E6	Gene names	SIRT5, SIR2L5
Domain Architecture
Description	NAD-dependent deacetylase sirtuin-5 (EC 3.5.1.-) (SIR2-like protein 5).

TSH3_MOUSE
θ value	6.88961 (rank : 15)	NC score	0.006799 (rank : 18)
Query Neighborhood Hits	18	Target Neighborhood Hits	590	Shared Neighborhood Hits	2
SwissProt Accessions	Q8CGV9, Q5DTX4	Gene names	Tshz3, Kiaa1474, Tsh3, Zfp537, Znf537
Domain Architecture	No domain graphic available
Description	Teashirt homolog 3 (Zinc finger protein 537).

CEP68_MOUSE
θ value	8.99809 (rank : 16)	NC score	0.012245 (rank : 15)
Query Neighborhood Hits	18	Target Neighborhood Hits	62	Shared Neighborhood Hits	2
SwissProt Accessions	Q8C0D9, Q3US49, Q5SW85, Q8R2V0	Gene names	Cep68
Domain Architecture	No domain graphic available
Description	Centrosomal protein of 68 kDa (Cep68 protein).

DOT1L_HUMAN
θ value	8.99809 (rank : 17)	NC score	0.009369 (rank : 16)
Query Neighborhood Hits	18	Target Neighborhood Hits	660	Shared Neighborhood Hits	2
SwissProt Accessions	Q8TEK3, O60379, Q96JL1	Gene names	DOT1L, KIAA1814
Domain Architecture	No domain graphic available
Description	Histone-lysine N-methyltransferase, H3 lysine-79 specific (EC 2.1.1.43) (Histone H3-K79 methyltransferase) (H3-K79-HMTase) (DOT1-like protein).

WBS14_HUMAN
θ value	8.99809 (rank : 18)	NC score	0.009306 (rank : 17)
Query Neighborhood Hits	18	Target Neighborhood Hits	273	Shared Neighborhood Hits	2
SwissProt Accessions	Q9NP71, Q96E48, Q9BY03, Q9BY04, Q9BY05, Q9BY06, Q9Y2P3	Gene names	MLXIPL, MIO, WBSCR14
Domain Architecture
Description	Williams-Beuren syndrome chromosome region 14 protein (WS basic-helix- loop-helix leucine zipper protein) (WS-bHLH) (Mlx interactor) (MLX- interacting protein-like).

Hits sorted by NC score

SIRT6_MOUSE
NC score	0.999962 (rank : 1)	θ value	0 (rank : 1)
Query Neighborhood Hits	18	Target Neighborhood Hits	18	Shared Neighborhood Hits	18
SwissProt Accessions	P59941	Gene names	Sirt6, Sir2l6
Domain Architecture
Description	Mono-ADP-ribosyltransferase sirtuin-6 (EC 2.4.2.31) (SIR2-like protein 6).

SIRT6_HUMAN
NC score	0.995022 (rank : 2)	θ value	9.15662e-170 (rank : 2)
Query Neighborhood Hits	18	Target Neighborhood Hits	29	Shared Neighborhood Hits	14
SwissProt Accessions	Q8N6T7, O75291, Q6IAF5, Q6PK99, Q8NCD2, Q9BSI5, Q9BWP3, Q9NRC7, Q9UQD1	Gene names	SIRT6, SIR2L6
Domain Architecture
Description	Mono-ADP-ribosyltransferase sirtuin-6 (EC 2.4.2.31) (SIR2-like protein 6).

SIRT7_HUMAN
NC score	0.886895 (rank : 3)	θ value	1.91475e-42 (rank : 4)
Query Neighborhood Hits	18	Target Neighborhood Hits	29	Shared Neighborhood Hits	14
SwissProt Accessions	Q9NRC8, Q3MIK4, Q9NSZ6, Q9NUS6	Gene names	SIRT7, SIR2L7
Domain Architecture
Description	NAD-dependent deacetylase sirtuin-7 (EC 3.5.1.-) (SIR2-like protein 7).

SIRT7_MOUSE
NC score	0.883581 (rank : 4)	θ value	2.26182e-43 (rank : 3)
Query Neighborhood Hits	18	Target Neighborhood Hits	44	Shared Neighborhood Hits	14
SwissProt Accessions	Q8BKJ9, Q6X7B7, Q8QZZ5	Gene names	Sirt7, Sir2l7
Domain Architecture
Description	NAD-dependent deacetylase sirtuin-7 (EC 3.5.1.-) (SIR2-like protein 7).

SIRT4_MOUSE
NC score	0.744564 (rank : 5)	θ value	6.20254e-17 (rank : 5)
Query Neighborhood Hits	18	Target Neighborhood Hits	16	Shared Neighborhood Hits	14
SwissProt Accessions	Q8R216	Gene names	Sirt4, Sir2l4
Domain Architecture
Description	NAD-dependent deacetylase sirtuin-4 (EC 3.5.1.-) (SIR2-like protein 4).

SIRT4_HUMAN
NC score	0.743735 (rank : 6)	θ value	5.25075e-16 (rank : 7)
Query Neighborhood Hits	18	Target Neighborhood Hits	14	Shared Neighborhood Hits	14
SwissProt Accessions	Q9Y6E7, O43346	Gene names	SIRT4, SIR2L4
Domain Architecture
Description	NAD-dependent deacetylase sirtuin-4 (EC 3.5.1.-) (SIR2-like protein 4).

SIRT3_MOUSE
NC score	0.708987 (rank : 7)	θ value	8.95645e-16 (rank : 8)
Query Neighborhood Hits	18	Target Neighborhood Hits	18	Shared Neighborhood Hits	14
SwissProt Accessions	Q8R104, Q9EPA8	Gene names	Sirt3, Sir2l3
Domain Architecture
Description	NAD-dependent deacetylase sirtuin-3 (EC 3.5.1.-) (SIR2-like protein 3) (mSIR2L3).

SIRT3_HUMAN
NC score	0.704796 (rank : 8)	θ value	3.07829e-16 (rank : 6)
Query Neighborhood Hits	18	Target Neighborhood Hits	18	Shared Neighborhood Hits	14
SwissProt Accessions	Q9NTG7, Q9Y6E8	Gene names	SIRT3, SIR2L3
Domain Architecture
Description	NAD-dependent deacetylase sirtuin-3, mitochondrial precursor (EC 3.5.1.-) (SIR2-like protein 3) (hSIRT3).

SIRT2_MOUSE
NC score	0.670883 (rank : 9)	θ value	2.69671e-12 (rank : 9)
Query Neighborhood Hits	18	Target Neighborhood Hits	15	Shared Neighborhood Hits	14
SwissProt Accessions	Q8VDQ8, Q9CXS5, Q9EQ18, Q9ERJ9	Gene names	Sirt2, Sir2l2
Domain Architecture
Description	NAD-dependent deacetylase sirtuin-2 (EC 3.5.1.-) (SIR2-like protein 2) (mSIR2L2).

SIRT2_HUMAN
NC score	0.655523 (rank : 10)	θ value	1.133e-10 (rank : 10)
Query Neighborhood Hits	18	Target Neighborhood Hits	16	Shared Neighborhood Hits	14
SwissProt Accessions	Q8IXJ6, O95889, Q924Y7, Q9P0G8, Q9UNT0, Q9Y6E9	Gene names	SIRT2, SIR2L, SIR2L2
Domain Architecture
Description	NAD-dependent deacetylase sirtuin-2 (EC 3.5.1.-) (SIR2-like) (SIR2- like protein 2).

SIRT5_MOUSE
NC score	0.634091 (rank : 11)	θ value	4.76016e-09 (rank : 13)
Query Neighborhood Hits	18	Target Neighborhood Hits	19	Shared Neighborhood Hits	14
SwissProt Accessions	Q8K2C6	Gene names	Sirt5, Sir2l5
Domain Architecture
Description	NAD-dependent deacetylase sirtuin-5 (EC 3.5.1.-) (SIR2-like protein 5).

SIRT5_HUMAN
NC score	0.622658 (rank : 12)	θ value	6.87365e-08 (rank : 14)
Query Neighborhood Hits	18	Target Neighborhood Hits	17	Shared Neighborhood Hits	14
SwissProt Accessions	Q9NXA8, Q9Y6E6	Gene names	SIRT5, SIR2L5
Domain Architecture
Description	NAD-dependent deacetylase sirtuin-5 (EC 3.5.1.-) (SIR2-like protein 5).

SIRT1_MOUSE
NC score	0.603922 (rank : 13)	θ value	2.52405e-10 (rank : 11)
Query Neighborhood Hits	18	Target Neighborhood Hits	50	Shared Neighborhood Hits	14
SwissProt Accessions	Q923E4, Q9QXG8	Gene names	Sirt1, Sir2l1
Domain Architecture
Description	NAD-dependent deacetylase sirtuin-1 (EC 3.5.1.-) (SIR2alpha) (mSIR2a) (Sir2) (SIR2-like protein 1).

SIRT1_HUMAN
NC score	0.599351 (rank : 14)	θ value	9.59137e-10 (rank : 12)
Query Neighborhood Hits	18	Target Neighborhood Hits	44	Shared Neighborhood Hits	14
SwissProt Accessions	Q96EB6, Q2XNF6, Q5JVQ0, Q9GZR9, Q9Y6F0	Gene names	SIRT1, SIR2L1
Domain Architecture
Description	NAD-dependent deacetylase sirtuin-1 (EC 3.5.1.-) (hSIRT1) (hSIR2) (SIR2-like protein 1).

CEP68_MOUSE
NC score	0.012245 (rank : 15)	θ value	8.99809 (rank : 16)
Query Neighborhood Hits	18	Target Neighborhood Hits	62	Shared Neighborhood Hits	2
SwissProt Accessions	Q8C0D9, Q3US49, Q5SW85, Q8R2V0	Gene names	Cep68
Domain Architecture	No domain graphic available
Description	Centrosomal protein of 68 kDa (Cep68 protein).

DOT1L_HUMAN
NC score	0.009369 (rank : 16)	θ value	8.99809 (rank : 17)
Query Neighborhood Hits	18	Target Neighborhood Hits	660	Shared Neighborhood Hits	2
SwissProt Accessions	Q8TEK3, O60379, Q96JL1	Gene names	DOT1L, KIAA1814
Domain Architecture	No domain graphic available
Description	Histone-lysine N-methyltransferase, H3 lysine-79 specific (EC 2.1.1.43) (Histone H3-K79 methyltransferase) (H3-K79-HMTase) (DOT1-like protein).

WBS14_HUMAN
NC score	0.009306 (rank : 17)	θ value	8.99809 (rank : 18)
Query Neighborhood Hits	18	Target Neighborhood Hits	273	Shared Neighborhood Hits	2
SwissProt Accessions	Q9NP71, Q96E48, Q9BY03, Q9BY04, Q9BY05, Q9BY06, Q9Y2P3	Gene names	MLXIPL, MIO, WBSCR14
Domain Architecture
Description	Williams-Beuren syndrome chromosome region 14 protein (WS basic-helix- loop-helix leucine zipper protein) (WS-bHLH) (Mlx interactor) (MLX- interacting protein-like).

TSH3_MOUSE
NC score	0.006799 (rank : 18)	θ value	6.88961 (rank : 15)
Query Neighborhood Hits	18	Target Neighborhood Hits	590	Shared Neighborhood Hits	2
SwissProt Accessions	Q8CGV9, Q5DTX4	Gene names	Tshz3, Kiaa1474, Tsh3, Zfp537, Znf537
Domain Architecture	No domain graphic available
Description	Teashirt homolog 3 (Zinc finger protein 537).