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Network neighborhood for query Sequence : D2HDH_HUMAN

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D2HDH_HUMAN
SwissProt Accessions	Q8N465, Q6IQ24, Q8N5Q8	Gene names	D2HGDH, D2HGD
Domain Architecture	No domain graphic available
Description	D-2-hydroxyglutarate dehydrogenase, mitochondrial precursor (EC 1.1.99.-).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

D2HDH_HUMAN
θ value	0 (rank : 1)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	19	Target Neighborhood Hits	19	Shared Neighborhood Hits	19
SwissProt Accessions	Q8N465, Q6IQ24, Q8N5Q8	Gene names	D2HGDH, D2HGD
Domain Architecture	No domain graphic available
Description	D-2-hydroxyglutarate dehydrogenase, mitochondrial precursor (EC 1.1.99.-).

D2HDH_MOUSE
θ value	0 (rank : 2)	NC score	0.994663 (rank : 2)
Query Neighborhood Hits	19	Target Neighborhood Hits	13	Shared Neighborhood Hits	8
SwissProt Accessions	Q8CIM3, Q3TDF5, Q8BU06	Gene names	D2hgdh
Domain Architecture	No domain graphic available
Description	D-2-hydroxyglutarate dehydrogenase, mitochondrial precursor (EC 1.1.99.-).

ADAS_HUMAN
θ value	1.42992e-13 (rank : 3)	NC score	0.511703 (rank : 3)
Query Neighborhood Hits	19	Target Neighborhood Hits	13	Shared Neighborhood Hits	5
SwissProt Accessions	O00116, Q2TU35	Gene names	AGPS
Domain Architecture
Description	Alkyldihydroxyacetonephosphate synthase, peroxisomal precursor (EC 2.5.1.26) (Alkyl-DHAP synthase) (Alkylglycerone-phosphate synthase) (Aging-associated protein 5).

ADAS_MOUSE
θ value	5.43371e-13 (rank : 4)	NC score	0.508197 (rank : 4)
Query Neighborhood Hits	19	Target Neighborhood Hits	8	Shared Neighborhood Hits	5
SwissProt Accessions	Q8C0I1	Gene names	Agps
Domain Architecture	No domain graphic available
Description	Alkyldihydroxyacetonephosphate synthase, peroxisomal precursor (EC 2.5.1.26) (Alkyl-DHAP synthase) (Alkylglycerone-phosphate synthase).

GGLO_MOUSE
θ value	2.52405e-10 (rank : 5)	NC score	0.478608 (rank : 5)
Query Neighborhood Hits	19	Target Neighborhood Hits	9	Shared Neighborhood Hits	6
SwissProt Accessions	P58710	Gene names	Gulo
Domain Architecture
Description	L-gulonolactone oxidase (EC 1.1.3.8) (LGO) (L-gulono-gamma-lactone oxidase) (GLO).

MPDZ_HUMAN
θ value	0.163984 (rank : 6)	NC score	0.033377 (rank : 7)
Query Neighborhood Hits	19	Target Neighborhood Hits	261	Shared Neighborhood Hits	3
SwissProt Accessions	O75970, O43798, Q5CZ80, Q5JTX3, Q5JTX6, Q5JTX7, Q5JUC3, Q5JUC4, Q5VZ62, Q8N790	Gene names	MPDZ, MUPP1
Domain Architecture	No domain graphic available
Description	Multiple PDZ domain protein (Multi PDZ domain protein 1) (Multi-PDZ- domain protein 1).

MARK3_MOUSE
θ value	2.36792 (rank : 7)	NC score	0.007438 (rank : 17)
Query Neighborhood Hits	19	Target Neighborhood Hits	919	Shared Neighborhood Hits	4
SwissProt Accessions	Q03141, Q3TM40, Q3V1U3, Q8C6G9, Q8R375, Q9JKE4	Gene names	Mark3, Emk2, Mpk10
Domain Architecture	No domain graphic available
Description	MAP/microtubule affinity-regulating kinase 3 (EC 2.7.11.1) (MPK-10) (ELKL motif kinase 2).

COHA1_HUMAN
θ value	3.0926 (rank : 8)	NC score	0.018689 (rank : 10)
Query Neighborhood Hits	19	Target Neighborhood Hits	400	Shared Neighborhood Hits	6
SwissProt Accessions	Q9UMD9, Q02802, Q99018, Q9NQK9, Q9UC14	Gene names	COL17A1, BP180, BPAG2
Domain Architecture	No domain graphic available
Description	Collagen alpha-1(XVII) chain (Bullous pemphigoid antigen 2) (180 kDa bullous pemphigoid antigen 2).

MARK3_HUMAN
θ value	3.0926 (rank : 9)	NC score	0.007629 (rank : 16)
Query Neighborhood Hits	19	Target Neighborhood Hits	893	Shared Neighborhood Hits	4
SwissProt Accessions	P27448, O60219, Q8TB41, Q8WX83, Q96RG1, Q9UMY9, Q9UN34	Gene names	MARK3, CTAK1
Domain Architecture
Description	MAP/microtubule affinity-regulating kinase 3 (EC 2.7.11.1) (Cdc25C- associated protein kinase 1) (cTAK1) (C-TAK1) (Serine/threonine protein kinase p78) (Ser/Thr protein kinase PAR-1) (Protein kinase STK10).

MPDZ_MOUSE
θ value	3.0926 (rank : 10)	NC score	0.027117 (rank : 8)
Query Neighborhood Hits	19	Target Neighborhood Hits	298	Shared Neighborhood Hits	3
SwissProt Accessions	Q8VBX6, O08783, Q6P7U4, Q80ZY8, Q8BKJ1, Q8C0H8, Q8VBV5, Q8VBY0, Q9Z1K3	Gene names	Mpdz, Mupp1
Domain Architecture	No domain graphic available
Description	Multiple PDZ domain protein (Multi PDZ domain protein 1) (Multi-PDZ domain protein 1).

CO1A2_HUMAN
θ value	5.27518 (rank : 11)	NC score	0.014050 (rank : 11)
Query Neighborhood Hits	19	Target Neighborhood Hits	329	Shared Neighborhood Hits	6
SwissProt Accessions	P08123, P02464, Q9UEB6, Q9UPH0	Gene names	COL1A2
Domain Architecture
Description	Collagen alpha-2(I) chain precursor.

CO4A1_MOUSE
θ value	5.27518 (rank : 12)	NC score	0.012384 (rank : 12)
Query Neighborhood Hits	19	Target Neighborhood Hits	450	Shared Neighborhood Hits	6
SwissProt Accessions	P02463	Gene names	Col4a1
Domain Architecture
Description	Collagen alpha-1(IV) chain precursor.

DHC24_HUMAN
θ value	5.27518 (rank : 13)	NC score	0.094608 (rank : 6)
Query Neighborhood Hits	19	Target Neighborhood Hits	8	Shared Neighborhood Hits	4
SwissProt Accessions	Q15392, Q9HBA8	Gene names	DHCR24, KIAA0018
Domain Architecture
Description	24-dehydrocholesterol reductase precursor (EC 1.3.1.-) (3-beta- hydroxysterol delta-24-reductase) (Seladin-1) (Diminuto/dwarf1 homolog).

HYEP_HUMAN
θ value	5.27518 (rank : 14)	NC score	0.022699 (rank : 9)
Query Neighborhood Hits	19	Target Neighborhood Hits	8	Shared Neighborhood Hits	2
SwissProt Accessions	P07099, Q5VTJ6, Q9NP75, Q9NPE7, Q9NQU6, Q9NQU7, Q9NQU8, Q9NQU9, Q9NQV0, Q9NQV1, Q9NQV2	Gene names	EPHX1, EPHX, EPOX
Domain Architecture
Description	Epoxide hydrolase 1 (EC 3.3.2.9) (Microsomal epoxide hydrolase) (Epoxide hydratase).

KIFC2_HUMAN
θ value	6.88961 (rank : 15)	NC score	0.006473 (rank : 18)
Query Neighborhood Hits	19	Target Neighborhood Hits	237	Shared Neighborhood Hits	2
SwissProt Accessions	Q96AC6	Gene names	KIFC2
Domain Architecture
Description	Kinesin-like protein KIFC2.

CO1A2_MOUSE
θ value	8.99809 (rank : 16)	NC score	0.012204 (rank : 13)
Query Neighborhood Hits	19	Target Neighborhood Hits	388	Shared Neighborhood Hits	6
SwissProt Accessions	Q01149, Q8CGA5	Gene names	Col1a2, Cola2
Domain Architecture
Description	Collagen alpha-2(I) chain precursor.

CO4A6_HUMAN
θ value	8.99809 (rank : 17)	NC score	0.011455 (rank : 14)
Query Neighborhood Hits	19	Target Neighborhood Hits	318	Shared Neighborhood Hits	6
SwissProt Accessions	Q14031, Q12823, Q14053, Q5JYH6, Q9NQM5, Q9NTX3, Q9UJ76, Q9UMG6, Q9Y4L4	Gene names	COL4A6
Domain Architecture
Description	Collagen alpha-6(IV) chain precursor.

PLXB1_HUMAN
θ value	8.99809 (rank : 18)	NC score	0.005561 (rank : 19)
Query Neighborhood Hits	19	Target Neighborhood Hits	360	Shared Neighborhood Hits	2
SwissProt Accessions	O43157, Q6NY20, Q9UIV7, Q9UJ92, Q9UJ93	Gene names	PLXNB1, KIAA0407, SEP
Domain Architecture	No domain graphic available
Description	Plexin-B1 precursor (Semaphorin receptor SEP).

SIRT3_HUMAN
θ value	8.99809 (rank : 19)	NC score	0.010645 (rank : 15)
Query Neighborhood Hits	19	Target Neighborhood Hits	18	Shared Neighborhood Hits	2
SwissProt Accessions	Q9NTG7, Q9Y6E8	Gene names	SIRT3, SIR2L3
Domain Architecture
Description	NAD-dependent deacetylase sirtuin-3, mitochondrial precursor (EC 3.5.1.-) (SIR2-like protein 3) (hSIRT3).

Hits sorted by NC score

D2HDH_HUMAN
NC score	0.999962 (rank : 1)	θ value	0 (rank : 1)
Query Neighborhood Hits	19	Target Neighborhood Hits	19	Shared Neighborhood Hits	19
SwissProt Accessions	Q8N465, Q6IQ24, Q8N5Q8	Gene names	D2HGDH, D2HGD
Domain Architecture	No domain graphic available
Description	D-2-hydroxyglutarate dehydrogenase, mitochondrial precursor (EC 1.1.99.-).

D2HDH_MOUSE
NC score	0.994663 (rank : 2)	θ value	0 (rank : 2)
Query Neighborhood Hits	19	Target Neighborhood Hits	13	Shared Neighborhood Hits	8
SwissProt Accessions	Q8CIM3, Q3TDF5, Q8BU06	Gene names	D2hgdh
Domain Architecture	No domain graphic available
Description	D-2-hydroxyglutarate dehydrogenase, mitochondrial precursor (EC 1.1.99.-).

ADAS_HUMAN
NC score	0.511703 (rank : 3)	θ value	1.42992e-13 (rank : 3)
Query Neighborhood Hits	19	Target Neighborhood Hits	13	Shared Neighborhood Hits	5
SwissProt Accessions	O00116, Q2TU35	Gene names	AGPS
Domain Architecture
Description	Alkyldihydroxyacetonephosphate synthase, peroxisomal precursor (EC 2.5.1.26) (Alkyl-DHAP synthase) (Alkylglycerone-phosphate synthase) (Aging-associated protein 5).

ADAS_MOUSE
NC score	0.508197 (rank : 4)	θ value	5.43371e-13 (rank : 4)
Query Neighborhood Hits	19	Target Neighborhood Hits	8	Shared Neighborhood Hits	5
SwissProt Accessions	Q8C0I1	Gene names	Agps
Domain Architecture	No domain graphic available
Description	Alkyldihydroxyacetonephosphate synthase, peroxisomal precursor (EC 2.5.1.26) (Alkyl-DHAP synthase) (Alkylglycerone-phosphate synthase).

GGLO_MOUSE
NC score	0.478608 (rank : 5)	θ value	2.52405e-10 (rank : 5)
Query Neighborhood Hits	19	Target Neighborhood Hits	9	Shared Neighborhood Hits	6
SwissProt Accessions	P58710	Gene names	Gulo
Domain Architecture
Description	L-gulonolactone oxidase (EC 1.1.3.8) (LGO) (L-gulono-gamma-lactone oxidase) (GLO).

DHC24_HUMAN
NC score	0.094608 (rank : 6)	θ value	5.27518 (rank : 13)
Query Neighborhood Hits	19	Target Neighborhood Hits	8	Shared Neighborhood Hits	4
SwissProt Accessions	Q15392, Q9HBA8	Gene names	DHCR24, KIAA0018
Domain Architecture
Description	24-dehydrocholesterol reductase precursor (EC 1.3.1.-) (3-beta- hydroxysterol delta-24-reductase) (Seladin-1) (Diminuto/dwarf1 homolog).

MPDZ_HUMAN
NC score	0.033377 (rank : 7)	θ value	0.163984 (rank : 6)
Query Neighborhood Hits	19	Target Neighborhood Hits	261	Shared Neighborhood Hits	3
SwissProt Accessions	O75970, O43798, Q5CZ80, Q5JTX3, Q5JTX6, Q5JTX7, Q5JUC3, Q5JUC4, Q5VZ62, Q8N790	Gene names	MPDZ, MUPP1
Domain Architecture	No domain graphic available
Description	Multiple PDZ domain protein (Multi PDZ domain protein 1) (Multi-PDZ- domain protein 1).

MPDZ_MOUSE
NC score	0.027117 (rank : 8)	θ value	3.0926 (rank : 10)
Query Neighborhood Hits	19	Target Neighborhood Hits	298	Shared Neighborhood Hits	3
SwissProt Accessions	Q8VBX6, O08783, Q6P7U4, Q80ZY8, Q8BKJ1, Q8C0H8, Q8VBV5, Q8VBY0, Q9Z1K3	Gene names	Mpdz, Mupp1
Domain Architecture	No domain graphic available
Description	Multiple PDZ domain protein (Multi PDZ domain protein 1) (Multi-PDZ domain protein 1).

HYEP_HUMAN
NC score	0.022699 (rank : 9)	θ value	5.27518 (rank : 14)
Query Neighborhood Hits	19	Target Neighborhood Hits	8	Shared Neighborhood Hits	2
SwissProt Accessions	P07099, Q5VTJ6, Q9NP75, Q9NPE7, Q9NQU6, Q9NQU7, Q9NQU8, Q9NQU9, Q9NQV0, Q9NQV1, Q9NQV2	Gene names	EPHX1, EPHX, EPOX
Domain Architecture
Description	Epoxide hydrolase 1 (EC 3.3.2.9) (Microsomal epoxide hydrolase) (Epoxide hydratase).

COHA1_HUMAN
NC score	0.018689 (rank : 10)	θ value	3.0926 (rank : 8)
Query Neighborhood Hits	19	Target Neighborhood Hits	400	Shared Neighborhood Hits	6
SwissProt Accessions	Q9UMD9, Q02802, Q99018, Q9NQK9, Q9UC14	Gene names	COL17A1, BP180, BPAG2
Domain Architecture	No domain graphic available
Description	Collagen alpha-1(XVII) chain (Bullous pemphigoid antigen 2) (180 kDa bullous pemphigoid antigen 2).

CO1A2_HUMAN
NC score	0.014050 (rank : 11)	θ value	5.27518 (rank : 11)
Query Neighborhood Hits	19	Target Neighborhood Hits	329	Shared Neighborhood Hits	6
SwissProt Accessions	P08123, P02464, Q9UEB6, Q9UPH0	Gene names	COL1A2
Domain Architecture
Description	Collagen alpha-2(I) chain precursor.

CO4A1_MOUSE
NC score	0.012384 (rank : 12)	θ value	5.27518 (rank : 12)
Query Neighborhood Hits	19	Target Neighborhood Hits	450	Shared Neighborhood Hits	6
SwissProt Accessions	P02463	Gene names	Col4a1
Domain Architecture
Description	Collagen alpha-1(IV) chain precursor.

CO1A2_MOUSE
NC score	0.012204 (rank : 13)	θ value	8.99809 (rank : 16)
Query Neighborhood Hits	19	Target Neighborhood Hits	388	Shared Neighborhood Hits	6
SwissProt Accessions	Q01149, Q8CGA5	Gene names	Col1a2, Cola2
Domain Architecture
Description	Collagen alpha-2(I) chain precursor.

CO4A6_HUMAN
NC score	0.011455 (rank : 14)	θ value	8.99809 (rank : 17)
Query Neighborhood Hits	19	Target Neighborhood Hits	318	Shared Neighborhood Hits	6
SwissProt Accessions	Q14031, Q12823, Q14053, Q5JYH6, Q9NQM5, Q9NTX3, Q9UJ76, Q9UMG6, Q9Y4L4	Gene names	COL4A6
Domain Architecture
Description	Collagen alpha-6(IV) chain precursor.

SIRT3_HUMAN
NC score	0.010645 (rank : 15)	θ value	8.99809 (rank : 19)
Query Neighborhood Hits	19	Target Neighborhood Hits	18	Shared Neighborhood Hits	2
SwissProt Accessions	Q9NTG7, Q9Y6E8	Gene names	SIRT3, SIR2L3
Domain Architecture
Description	NAD-dependent deacetylase sirtuin-3, mitochondrial precursor (EC 3.5.1.-) (SIR2-like protein 3) (hSIRT3).

MARK3_HUMAN
NC score	0.007629 (rank : 16)	θ value	3.0926 (rank : 9)
Query Neighborhood Hits	19	Target Neighborhood Hits	893	Shared Neighborhood Hits	4
SwissProt Accessions	P27448, O60219, Q8TB41, Q8WX83, Q96RG1, Q9UMY9, Q9UN34	Gene names	MARK3, CTAK1
Domain Architecture
Description	MAP/microtubule affinity-regulating kinase 3 (EC 2.7.11.1) (Cdc25C- associated protein kinase 1) (cTAK1) (C-TAK1) (Serine/threonine protein kinase p78) (Ser/Thr protein kinase PAR-1) (Protein kinase STK10).

MARK3_MOUSE
NC score	0.007438 (rank : 17)	θ value	2.36792 (rank : 7)
Query Neighborhood Hits	19	Target Neighborhood Hits	919	Shared Neighborhood Hits	4
SwissProt Accessions	Q03141, Q3TM40, Q3V1U3, Q8C6G9, Q8R375, Q9JKE4	Gene names	Mark3, Emk2, Mpk10
Domain Architecture	No domain graphic available
Description	MAP/microtubule affinity-regulating kinase 3 (EC 2.7.11.1) (MPK-10) (ELKL motif kinase 2).

KIFC2_HUMAN
NC score	0.006473 (rank : 18)	θ value	6.88961 (rank : 15)
Query Neighborhood Hits	19	Target Neighborhood Hits	237	Shared Neighborhood Hits	2
SwissProt Accessions	Q96AC6	Gene names	KIFC2
Domain Architecture
Description	Kinesin-like protein KIFC2.

PLXB1_HUMAN
NC score	0.005561 (rank : 19)	θ value	8.99809 (rank : 18)
Query Neighborhood Hits	19	Target Neighborhood Hits	360	Shared Neighborhood Hits	2
SwissProt Accessions	O43157, Q6NY20, Q9UIV7, Q9UJ92, Q9UJ93	Gene names	PLXNB1, KIAA0407, SEP
Domain Architecture	No domain graphic available
Description	Plexin-B1 precursor (Semaphorin receptor SEP).