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Network neighborhood for query Sequence : RNZ1_HUMAN

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RNZ1_HUMAN
SwissProt Accessions	Q9H777, Q9NS99	Gene names	ELAC1, D29
Domain Architecture
Description	Zinc phosphodiesterase ELAC protein 1 (EC 3.1.26.11) (Ribonuclease Z 1) (RNase Z 1) (tRNase Z 1) (tRNA 3 endonuclease 1) (ElaC homolog protein 1) (Deleted in Ma29).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

RNZ1_HUMAN
θ value	0 (rank : 1)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	12	Target Neighborhood Hits	12	Shared Neighborhood Hits	12
SwissProt Accessions	Q9H777, Q9NS99	Gene names	ELAC1, D29
Domain Architecture
Description	Zinc phosphodiesterase ELAC protein 1 (EC 3.1.26.11) (Ribonuclease Z 1) (RNase Z 1) (tRNase Z 1) (tRNA 3 endonuclease 1) (ElaC homolog protein 1) (Deleted in Ma29).

RNZ1_MOUSE
θ value	0 (rank : 2)	NC score	0.999045 (rank : 2)
Query Neighborhood Hits	12	Target Neighborhood Hits	8	Shared Neighborhood Hits	8
SwissProt Accessions	Q8VEB6, Q9CXB1, Q9ERF4	Gene names	Elac1
Domain Architecture
Description	Zinc phosphodiesterase ELAC protein 1 (EC 3.1.26.11) (Ribonuclease Z 1) (RNase Z 1) (tRNase Z 1) (tRNA 3 endonuclease 1) (ElaC homolog protein 1).

RNZ2_HUMAN
θ value	8.11959e-09 (rank : 3)	NC score	0.396507 (rank : 3)
Query Neighborhood Hits	12	Target Neighborhood Hits	17	Shared Neighborhood Hits	4
SwissProt Accessions	Q9BQ52, Q9HAS8, Q9HAS9, Q9NVT1	Gene names	ELAC2, HPC2
Domain Architecture
Description	Zinc phosphodiesterase ELAC protein 2 (EC 3.1.26.11) (Ribonuclease Z 2) (RNase Z 2) (tRNase Z 2) (tRNA 3 endonuclease 2) (ElaC homolog protein 2) (Heredity prostate cancer protein 2).

RNZ2_MOUSE
θ value	4.0297e-08 (rank : 4)	NC score	0.382855 (rank : 4)
Query Neighborhood Hits	12	Target Neighborhood Hits	26	Shared Neighborhood Hits	4
SwissProt Accessions	Q80Y81, Q99MF0, Q99MF1, Q9CTA2, Q9D1A8, Q9EPZ2	Gene names	Elac2
Domain Architecture
Description	Zinc phosphodiesterase ELAC protein 2 (EC 3.1.26.11) (Ribonuclease Z 2) (RNase Z 2) (tRNase Z 2) (tRNA 3 endonuclease 2) (ElaC homolog protein 2).

CPSF3_HUMAN
θ value	1.81305 (rank : 5)	NC score	0.065656 (rank : 6)
Query Neighborhood Hits	12	Target Neighborhood Hits	13	Shared Neighborhood Hits	4
SwissProt Accessions	Q9UKF6, O14769, Q96F36	Gene names	CPSF3, CPSF73
Domain Architecture
Description	Cleavage and polyadenylation specificity factor 73 kDa subunit (CPSF 73 kDa subunit).

CPSF3_MOUSE
θ value	1.81305 (rank : 6)	NC score	0.065764 (rank : 5)
Query Neighborhood Hits	12	Target Neighborhood Hits	12	Shared Neighborhood Hits	4
SwissProt Accessions	Q9QXK7	Gene names	Cpsf3, Cpsf73
Domain Architecture
Description	Cleavage and polyadenylation specificity factor 73 kDa subunit (CPSF 73 kDa subunit).

DEPD5_HUMAN
θ value	2.36792 (rank : 7)	NC score	0.055032 (rank : 7)
Query Neighborhood Hits	12	Target Neighborhood Hits	40	Shared Neighborhood Hits	4
SwissProt Accessions	O75140, Q5K3V5, Q5THY9, Q5THZ0, Q5THZ1, Q5THZ3, Q68DR1, Q6MZX3, Q6PEZ1, Q9UGV8, Q9UH13	Gene names	DEPDC5, KIAA0645
Domain Architecture
Description	DEP domain-containing protein 5.

DEPD5_MOUSE
θ value	5.27518 (rank : 8)	NC score	0.047491 (rank : 8)
Query Neighborhood Hits	12	Target Neighborhood Hits	32	Shared Neighborhood Hits	4
SwissProt Accessions	P61460	Gene names	Depdc5, Kiaa0645
Domain Architecture
Description	DEP domain-containing protein 5.

ZO3_HUMAN
θ value	5.27518 (rank : 9)	NC score	0.010760 (rank : 10)
Query Neighborhood Hits	12	Target Neighborhood Hits	219	Shared Neighborhood Hits	2
SwissProt Accessions	O95049	Gene names	TJP3, ZO3
Domain Architecture
Description	Tight junction protein ZO-3 (Zonula occludens 3 protein) (Zona occludens 3 protein) (Tight junction protein 3).

NEK1_HUMAN
θ value	6.88961 (rank : 10)	NC score	0.001278 (rank : 12)
Query Neighborhood Hits	12	Target Neighborhood Hits	1129	Shared Neighborhood Hits	2
SwissProt Accessions	Q96PY6, Q9Y594	Gene names	NEK1, KIAA1901
Domain Architecture
Description	Serine/threonine-protein kinase Nek1 (EC 2.7.11.1) (NimA-related protein kinase 1) (NY-REN-55 antigen).

SORL_MOUSE
θ value	6.88961 (rank : 11)	NC score	0.006270 (rank : 11)
Query Neighborhood Hits	12	Target Neighborhood Hits	439	Shared Neighborhood Hits	2
SwissProt Accessions	O88307, O54711, O70581	Gene names	Sorl1
Domain Architecture
Description	Sortilin-related receptor precursor (Sorting protein-related receptor containing LDLR class A repeats) (mSorLA) (SorLA-1) (Low-density lipoprotein receptor relative with 11 ligand-binding repeats) (LDLR relative with 11 ligand-binding repeats) (LR11) (Gp250).

NHEJ1_HUMAN
θ value	8.99809 (rank : 12)	NC score	0.018458 (rank : 9)
Query Neighborhood Hits	12	Target Neighborhood Hits	8	Shared Neighborhood Hits	2
SwissProt Accessions	Q9H9Q4, Q4ZFW7, Q6IA64, Q96JS9	Gene names	NHEJ1, XLF
Domain Architecture	No domain graphic available
Description	Non-homologous end-joining factor 1 (Protein cernunnos) (XRCC4-like factor).

Hits sorted by NC score

RNZ1_HUMAN
NC score	0.999962 (rank : 1)	θ value	0 (rank : 1)
Query Neighborhood Hits	12	Target Neighborhood Hits	12	Shared Neighborhood Hits	12
SwissProt Accessions	Q9H777, Q9NS99	Gene names	ELAC1, D29
Domain Architecture
Description	Zinc phosphodiesterase ELAC protein 1 (EC 3.1.26.11) (Ribonuclease Z 1) (RNase Z 1) (tRNase Z 1) (tRNA 3 endonuclease 1) (ElaC homolog protein 1) (Deleted in Ma29).

RNZ1_MOUSE
NC score	0.999045 (rank : 2)	θ value	0 (rank : 2)
Query Neighborhood Hits	12	Target Neighborhood Hits	8	Shared Neighborhood Hits	8
SwissProt Accessions	Q8VEB6, Q9CXB1, Q9ERF4	Gene names	Elac1
Domain Architecture
Description	Zinc phosphodiesterase ELAC protein 1 (EC 3.1.26.11) (Ribonuclease Z 1) (RNase Z 1) (tRNase Z 1) (tRNA 3 endonuclease 1) (ElaC homolog protein 1).

RNZ2_HUMAN
NC score	0.396507 (rank : 3)	θ value	8.11959e-09 (rank : 3)
Query Neighborhood Hits	12	Target Neighborhood Hits	17	Shared Neighborhood Hits	4
SwissProt Accessions	Q9BQ52, Q9HAS8, Q9HAS9, Q9NVT1	Gene names	ELAC2, HPC2
Domain Architecture
Description	Zinc phosphodiesterase ELAC protein 2 (EC 3.1.26.11) (Ribonuclease Z 2) (RNase Z 2) (tRNase Z 2) (tRNA 3 endonuclease 2) (ElaC homolog protein 2) (Heredity prostate cancer protein 2).

RNZ2_MOUSE
NC score	0.382855 (rank : 4)	θ value	4.0297e-08 (rank : 4)
Query Neighborhood Hits	12	Target Neighborhood Hits	26	Shared Neighborhood Hits	4
SwissProt Accessions	Q80Y81, Q99MF0, Q99MF1, Q9CTA2, Q9D1A8, Q9EPZ2	Gene names	Elac2
Domain Architecture
Description	Zinc phosphodiesterase ELAC protein 2 (EC 3.1.26.11) (Ribonuclease Z 2) (RNase Z 2) (tRNase Z 2) (tRNA 3 endonuclease 2) (ElaC homolog protein 2).

CPSF3_MOUSE
NC score	0.065764 (rank : 5)	θ value	1.81305 (rank : 6)
Query Neighborhood Hits	12	Target Neighborhood Hits	12	Shared Neighborhood Hits	4
SwissProt Accessions	Q9QXK7	Gene names	Cpsf3, Cpsf73
Domain Architecture
Description	Cleavage and polyadenylation specificity factor 73 kDa subunit (CPSF 73 kDa subunit).

CPSF3_HUMAN
NC score	0.065656 (rank : 6)	θ value	1.81305 (rank : 5)
Query Neighborhood Hits	12	Target Neighborhood Hits	13	Shared Neighborhood Hits	4
SwissProt Accessions	Q9UKF6, O14769, Q96F36	Gene names	CPSF3, CPSF73
Domain Architecture
Description	Cleavage and polyadenylation specificity factor 73 kDa subunit (CPSF 73 kDa subunit).

DEPD5_HUMAN
NC score	0.055032 (rank : 7)	θ value	2.36792 (rank : 7)
Query Neighborhood Hits	12	Target Neighborhood Hits	40	Shared Neighborhood Hits	4
SwissProt Accessions	O75140, Q5K3V5, Q5THY9, Q5THZ0, Q5THZ1, Q5THZ3, Q68DR1, Q6MZX3, Q6PEZ1, Q9UGV8, Q9UH13	Gene names	DEPDC5, KIAA0645
Domain Architecture
Description	DEP domain-containing protein 5.

DEPD5_MOUSE
NC score	0.047491 (rank : 8)	θ value	5.27518 (rank : 8)
Query Neighborhood Hits	12	Target Neighborhood Hits	32	Shared Neighborhood Hits	4
SwissProt Accessions	P61460	Gene names	Depdc5, Kiaa0645
Domain Architecture
Description	DEP domain-containing protein 5.

NHEJ1_HUMAN
NC score	0.018458 (rank : 9)	θ value	8.99809 (rank : 12)
Query Neighborhood Hits	12	Target Neighborhood Hits	8	Shared Neighborhood Hits	2
SwissProt Accessions	Q9H9Q4, Q4ZFW7, Q6IA64, Q96JS9	Gene names	NHEJ1, XLF
Domain Architecture	No domain graphic available
Description	Non-homologous end-joining factor 1 (Protein cernunnos) (XRCC4-like factor).

ZO3_HUMAN
NC score	0.010760 (rank : 10)	θ value	5.27518 (rank : 9)
Query Neighborhood Hits	12	Target Neighborhood Hits	219	Shared Neighborhood Hits	2
SwissProt Accessions	O95049	Gene names	TJP3, ZO3
Domain Architecture
Description	Tight junction protein ZO-3 (Zonula occludens 3 protein) (Zona occludens 3 protein) (Tight junction protein 3).

SORL_MOUSE
NC score	0.006270 (rank : 11)	θ value	6.88961 (rank : 11)
Query Neighborhood Hits	12	Target Neighborhood Hits	439	Shared Neighborhood Hits	2
SwissProt Accessions	O88307, O54711, O70581	Gene names	Sorl1
Domain Architecture
Description	Sortilin-related receptor precursor (Sorting protein-related receptor containing LDLR class A repeats) (mSorLA) (SorLA-1) (Low-density lipoprotein receptor relative with 11 ligand-binding repeats) (LDLR relative with 11 ligand-binding repeats) (LR11) (Gp250).

NEK1_HUMAN
NC score	0.001278 (rank : 12)	θ value	6.88961 (rank : 10)
Query Neighborhood Hits	12	Target Neighborhood Hits	1129	Shared Neighborhood Hits	2
SwissProt Accessions	Q96PY6, Q9Y594	Gene names	NEK1, KIAA1901
Domain Architecture
Description	Serine/threonine-protein kinase Nek1 (EC 2.7.11.1) (NimA-related protein kinase 1) (NY-REN-55 antigen).