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Network neighborhood for query Sequence : DEPD5_HUMAN

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DEPD5_HUMAN
SwissProt Accessions	O75140, Q5K3V5, Q5THY9, Q5THZ0, Q5THZ1, Q5THZ3, Q68DR1, Q6MZX3, Q6PEZ1, Q9UGV8, Q9UH13	Gene names	DEPDC5, KIAA0645
Domain Architecture
Description	DEP domain-containing protein 5.
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

DEPD5_HUMAN
θ value	0 (rank : 1)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	40	Target Neighborhood Hits	40	Shared Neighborhood Hits	40
SwissProt Accessions	O75140, Q5K3V5, Q5THY9, Q5THZ0, Q5THZ1, Q5THZ3, Q68DR1, Q6MZX3, Q6PEZ1, Q9UGV8, Q9UH13	Gene names	DEPDC5, KIAA0645
Domain Architecture
Description	DEP domain-containing protein 5.

DEPD5_MOUSE
θ value	0 (rank : 2)	NC score	0.992797 (rank : 2)
Query Neighborhood Hits	40	Target Neighborhood Hits	32	Shared Neighborhood Hits	18
SwissProt Accessions	P61460	Gene names	Depdc5, Kiaa0645
Domain Architecture
Description	DEP domain-containing protein 5.

DVL1_MOUSE
θ value	0.00869519 (rank : 3)	NC score	0.140351 (rank : 5)
Query Neighborhood Hits	40	Target Neighborhood Hits	146	Shared Neighborhood Hits	13
SwissProt Accessions	P51141, Q60868	Gene names	Dvl1, Dvl
Domain Architecture
Description	Segment polarity protein dishevelled homolog DVL-1 (Dishevelled-1) (DSH homolog 1).

RPGF4_MOUSE
θ value	0.0193708 (rank : 4)	NC score	0.086152 (rank : 10)
Query Neighborhood Hits	40	Target Neighborhood Hits	80	Shared Neighborhood Hits	14
SwissProt Accessions	Q9EQZ6, Q8VIP9, Q9CW52, Q9Z1P0	Gene names	Rapgef4, Cgef2, Epac2
Domain Architecture
Description	Rap guanine nucleotide exchange factor 4 (cAMP-regulated guanine nucleotide exchange factor II) (cAMP-GEFII) (Exchange factor directly activated by cAMP 2) (Epac 2) (cAMP-dependent Rap1 guanine-nucleotide exchange factor).

DVL1L_HUMAN
θ value	0.0330416 (rank : 5)	NC score	0.134759 (rank : 7)
Query Neighborhood Hits	40	Target Neighborhood Hits	146	Shared Neighborhood Hits	13
SwissProt Accessions	P54792	Gene names	DVL1L1, DVL, DVL1
Domain Architecture
Description	Segment polarity protein dishevelled homolog DVL-1-like (Dishevelled- 1-like) (DSH homolog 1-like).

DVL2_HUMAN
θ value	0.0330416 (rank : 6)	NC score	0.137021 (rank : 6)
Query Neighborhood Hits	40	Target Neighborhood Hits	223	Shared Neighborhood Hits	13
SwissProt Accessions	O14641	Gene names	DVL2
Domain Architecture
Description	Segment polarity protein dishevelled homolog DVL-2 (Dishevelled-2) (DSH homolog 2).

DVL3_HUMAN
θ value	0.0431538 (rank : 7)	NC score	0.147510 (rank : 4)
Query Neighborhood Hits	40	Target Neighborhood Hits	194	Shared Neighborhood Hits	13
SwissProt Accessions	Q92997, O14642, Q13531, Q8N5E9, Q92607	Gene names	DVL3, KIAA0208
Domain Architecture
Description	Segment polarity protein dishevelled homolog DVL-3 (Dishevelled-3) (DSH homolog 3).

DVL3_MOUSE
θ value	0.0431538 (rank : 8)	NC score	0.147649 (rank : 3)
Query Neighborhood Hits	40	Target Neighborhood Hits	198	Shared Neighborhood Hits	13
SwissProt Accessions	Q61062	Gene names	Dvl3
Domain Architecture
Description	Segment polarity protein dishevelled homolog DVL-3 (Dishevelled-3) (DSH homolog 3).

DVL1_HUMAN
θ value	0.0563607 (rank : 9)	NC score	0.130581 (rank : 9)
Query Neighborhood Hits	40	Target Neighborhood Hits	158	Shared Neighborhood Hits	12
SwissProt Accessions	O14640	Gene names	DVL1
Domain Architecture
Description	Segment polarity protein dishevelled homolog DVL-1 (Dishevelled-1) (DSH homolog 1).

DVL2_MOUSE
θ value	0.0563607 (rank : 10)	NC score	0.133602 (rank : 8)
Query Neighborhood Hits	40	Target Neighborhood Hits	233	Shared Neighborhood Hits	13
SwissProt Accessions	Q60838	Gene names	Dvl2
Domain Architecture
Description	Segment polarity protein dishevelled homolog DVL-2 (Dishevelled-2) (DSH homolog 2).

FYV1_MOUSE
θ value	0.125558 (rank : 11)	NC score	0.084397 (rank : 11)
Query Neighborhood Hits	40	Target Neighborhood Hits	191	Shared Neighborhood Hits	13
SwissProt Accessions	Q9Z1T6	Gene names	Pip5k3, Pikfyve
Domain Architecture
Description	FYVE finger-containing phosphoinositide kinase (EC 2.7.1.68) (1- phosphatidylinositol-4-phosphate 5-kinase) (PIP5K) (PtdIns(4)P-5- kinase) (PIKfyve) (p235).

FYV1_HUMAN
θ value	0.163984 (rank : 12)	NC score	0.084026 (rank : 12)
Query Neighborhood Hits	40	Target Neighborhood Hits	217	Shared Neighborhood Hits	14
SwissProt Accessions	Q9Y2I7, Q8NB67	Gene names	PIP5K3, KIAA0981, PIKFYVE
Domain Architecture
Description	FYVE finger-containing phosphoinositide kinase (EC 2.7.1.68) (1- phosphatidylinositol-4-phosphate 5-kinase) (Phosphatidylinositol-3- phosphate 5-kinase type III) (PIP5K) (PtdIns(4)P-5-kinase) (PIKfyve) (p235).

RPGF4_HUMAN
θ value	0.163984 (rank : 13)	NC score	0.077563 (rank : 13)
Query Neighborhood Hits	40	Target Neighborhood Hits	88	Shared Neighborhood Hits	12
SwissProt Accessions	Q8WZA2, O95636, Q8IXK6, Q8TAA4	Gene names	RAPGEF4, CGEF2, EPAC2
Domain Architecture
Description	Rap guanine nucleotide exchange factor 4 (cAMP-regulated guanine nucleotide exchange factor II) (cAMP-GEFII) (Exchange factor directly activated by cAMP 2) (Epac 2).

BMP10_MOUSE
θ value	0.365318 (rank : 14)	NC score	0.027219 (rank : 18)
Query Neighborhood Hits	40	Target Neighborhood Hits	75	Shared Neighborhood Hits	3
SwissProt Accessions	Q9R229, Q9Z1V8	Gene names	Bmp10
Domain Architecture
Description	Bone morphogenetic protein 10 precursor (BMP-10).

RPGF5_MOUSE
θ value	0.62314 (rank : 15)	NC score	0.058509 (rank : 14)
Query Neighborhood Hits	40	Target Neighborhood Hits	85	Shared Neighborhood Hits	11
SwissProt Accessions	Q8C0Q9, Q8BJJ9, Q8C0R5	Gene names	Rapgef5, Gfr, Kiaa0277, Mrgef
Domain Architecture
Description	Rap guanine nucleotide exchange factor 5 (Guanine nucleotide exchange factor for Rap1) (M-Ras-regulated Rap GEF) (MR-GEF).

DMD_MOUSE
θ value	1.81305 (rank : 16)	NC score	0.014250 (rank : 32)
Query Neighborhood Hits	40	Target Neighborhood Hits	1111	Shared Neighborhood Hits	7
SwissProt Accessions	P11531, O35653, Q60703	Gene names	Dmd
Domain Architecture
Description	Dystrophin.

NICA_HUMAN
θ value	1.81305 (rank : 17)	NC score	0.031140 (rank : 17)
Query Neighborhood Hits	40	Target Neighborhood Hits	14	Shared Neighborhood Hits	2
SwissProt Accessions	Q92542, Q86VV5	Gene names	NCSTN, KIAA0253
Domain Architecture
Description	Nicastrin precursor.

DMD_HUMAN
θ value	2.36792 (rank : 18)	NC score	0.014404 (rank : 30)
Query Neighborhood Hits	40	Target Neighborhood Hits	1135	Shared Neighborhood Hits	6
SwissProt Accessions	P11532, Q02295, Q14169, Q14170, Q5JYU0, Q7KZ48	Gene names	DMD
Domain Architecture
Description	Dystrophin.

RNZ1_HUMAN
θ value	2.36792 (rank : 19)	NC score	0.055032 (rank : 16)
Query Neighborhood Hits	40	Target Neighborhood Hits	12	Shared Neighborhood Hits	4
SwissProt Accessions	Q9H777, Q9NS99	Gene names	ELAC1, D29
Domain Architecture
Description	Zinc phosphodiesterase ELAC protein 1 (EC 3.1.26.11) (Ribonuclease Z 1) (RNase Z 1) (tRNase Z 1) (tRNA 3 endonuclease 1) (ElaC homolog protein 1) (Deleted in Ma29).

RNZ1_MOUSE
θ value	2.36792 (rank : 20)	NC score	0.055305 (rank : 15)
Query Neighborhood Hits	40	Target Neighborhood Hits	8	Shared Neighborhood Hits	4
SwissProt Accessions	Q8VEB6, Q9CXB1, Q9ERF4	Gene names	Elac1
Domain Architecture
Description	Zinc phosphodiesterase ELAC protein 1 (EC 3.1.26.11) (Ribonuclease Z 1) (RNase Z 1) (tRNase Z 1) (tRNA 3 endonuclease 1) (ElaC homolog protein 1).

CENPE_HUMAN
θ value	3.0926 (rank : 21)	NC score	0.008070 (rank : 36)
Query Neighborhood Hits	40	Target Neighborhood Hits	2060	Shared Neighborhood Hits	7
SwissProt Accessions	Q02224	Gene names	CENPE
Domain Architecture
Description	Centromeric protein E (CENP-E).

KSYK_MOUSE
θ value	3.0926 (rank : 22)	NC score	0.003421 (rank : 39)
Query Neighborhood Hits	40	Target Neighborhood Hits	944	Shared Neighborhood Hits	4
SwissProt Accessions	P48025	Gene names	Syk
Domain Architecture
Description	Tyrosine-protein kinase SYK (EC 2.7.10.2) (Spleen tyrosine kinase).

NFAT5_MOUSE
θ value	3.0926 (rank : 23)	NC score	0.021726 (rank : 19)
Query Neighborhood Hits	40	Target Neighborhood Hits	162	Shared Neighborhood Hits	4
SwissProt Accessions	Q9WV30	Gene names	Nfat5
Domain Architecture
Description	Nuclear factor of activated T-cells 5 (T cell transcription factor NFAT5) (NF-AT5) (Rel domain-containing transcription factor NFAT5).

GAK6_HUMAN
θ value	4.03905 (rank : 24)	NC score	0.021548 (rank : 20)
Query Neighborhood Hits	40	Target Neighborhood Hits	392	Shared Neighborhood Hits	8
SwissProt Accessions	P62685	Gene names
Domain Architecture	No domain graphic available
Description	HERV-K_8p23.1 provirus ancestral Gag polyprotein (Gag polyprotein) (HERV-K115 Gag protein) [Contains: Matrix protein; Capsid protein; Nucleocapsid protein].

KIF2C_MOUSE
θ value	4.03905 (rank : 25)	NC score	0.009501 (rank : 35)
Query Neighborhood Hits	40	Target Neighborhood Hits	96	Shared Neighborhood Hits	3
SwissProt Accessions	Q922S8	Gene names	Kif2c
Domain Architecture
Description	Kinesin-like protein KIF2C (Mitotic centromere-associated kinesin) (MCAK).

LTBP4_MOUSE
θ value	4.03905 (rank : 26)	NC score	0.004778 (rank : 38)
Query Neighborhood Hits	40	Target Neighborhood Hits	607	Shared Neighborhood Hits	2
SwissProt Accessions	Q8K4G1, Q8K4G0	Gene names	Ltbp4
Domain Architecture
Description	Latent-transforming growth factor beta-binding protein 4 precursor (LTBP-4).

CEL_MOUSE
θ value	6.88961 (rank : 27)	NC score	0.007469 (rank : 37)
Query Neighborhood Hits	40	Target Neighborhood Hits	28	Shared Neighborhood Hits	2
SwissProt Accessions	Q64285	Gene names	Cel, Lip1
Domain Architecture
Description	Bile salt-activated lipase precursor (EC 3.1.1.3) (EC 3.1.1.13) (BAL) (Bile salt-stimulated lipase) (BSSL) (Carboxyl ester lipase) (Sterol esterase) (Cholesterol esterase) (Pancreatic lysophospholipase).

KLDC4_HUMAN
θ value	6.88961 (rank : 28)	NC score	0.015304 (rank : 29)
Query Neighborhood Hits	40	Target Neighborhood Hits	46	Shared Neighborhood Hits	4
SwissProt Accessions	Q8TBB5, Q96F29, Q9BVN3	Gene names	KLHDC4
Domain Architecture	No domain graphic available
Description	Kelch domain-containing protein 4.

KSYK_HUMAN
θ value	6.88961 (rank : 29)	NC score	0.002541 (rank : 40)
Query Neighborhood Hits	40	Target Neighborhood Hits	901	Shared Neighborhood Hits	4
SwissProt Accessions	P43405	Gene names	SYK
Domain Architecture
Description	Tyrosine-protein kinase SYK (EC 2.7.10.2) (Spleen tyrosine kinase).

SMOO_HUMAN
θ value	6.88961 (rank : 30)	NC score	0.014299 (rank : 31)
Query Neighborhood Hits	40	Target Neighborhood Hits	391	Shared Neighborhood Hits	4
SwissProt Accessions	P53814, O00569, O95769, O95937, Q9P1S8, Q9UIT1, Q9UIT2	Gene names	SMTN, SMSMO
Domain Architecture
Description	Smoothelin.

STAU2_HUMAN
θ value	6.88961 (rank : 31)	NC score	0.018356 (rank : 27)
Query Neighborhood Hits	40	Target Neighborhood Hits	34	Shared Neighborhood Hits	3
SwissProt Accessions	Q9NUL3, Q6AHY7, Q96HM0, Q96HM1, Q9NVI5, Q9UGG6	Gene names	STAU2
Domain Architecture	No domain graphic available
Description	Double-stranded RNA-binding protein Staufen homolog 2.

STAU2_MOUSE
θ value	6.88961 (rank : 32)	NC score	0.018219 (rank : 28)
Query Neighborhood Hits	40	Target Neighborhood Hits	35	Shared Neighborhood Hits	3
SwissProt Accessions	Q8CJ67, Q8BSY8, Q8CJ66, Q8R175, Q91Z19, Q9D5N7	Gene names	Stau2
Domain Architecture	No domain graphic available
Description	Double-stranded RNA-binding protein Staufen homolog 2.

GAK11_HUMAN
θ value	8.99809 (rank : 33)	NC score	0.019604 (rank : 25)
Query Neighborhood Hits	40	Target Neighborhood Hits	409	Shared Neighborhood Hits	8
SwissProt Accessions	P63145, Q9UKI1	Gene names
Domain Architecture	No domain graphic available
Description	HERV-K_22q11.21 provirus ancestral Gag polyprotein (Gag polyprotein) (HERV-K101 Gag protein) [Contains: Matrix protein; Capsid protein; Nucleocapsid protein].

GAK12_HUMAN
θ value	8.99809 (rank : 34)	NC score	0.019808 (rank : 22)
Query Neighborhood Hits	40	Target Neighborhood Hits	374	Shared Neighborhood Hits	8
SwissProt Accessions	P63130, Q9UKI0	Gene names
Domain Architecture	No domain graphic available
Description	HERV-K_1q22 provirus ancestral Gag polyprotein (Gag polyprotein) (HERV-K102 Gag protein) (HERV-K(III) Gag protein) [Contains: Matrix protein; Capsid protein; Nucleocapsid protein].

GAK1_HUMAN
θ value	8.99809 (rank : 35)	NC score	0.020128 (rank : 21)
Query Neighborhood Hits	40	Target Neighborhood Hits	268	Shared Neighborhood Hits	8
SwissProt Accessions	P62683	Gene names
Domain Architecture	No domain graphic available
Description	HERV-K_12q14.1 provirus ancestral Gag polyprotein (Gag polyprotein) [Contains: Matrix protein; Capsid protein; Nucleocapsid protein].

GAK2_HUMAN
θ value	8.99809 (rank : 36)	NC score	0.019627 (rank : 23)
Query Neighborhood Hits	40	Target Neighborhood Hits	406	Shared Neighborhood Hits	8
SwissProt Accessions	Q7LDI9, Q9UKH5, Q9Y6I1, Q9YNA6, Q9YNB0	Gene names	ERVK6
Domain Architecture	No domain graphic available
Description	HERV-K_7p22.1 provirus ancestral Gag polyprotein (Gag polyprotein) (HERV-K(HML-2.HOM) Gag protein) (HERV-K108 Gag protein) (HERV-K(C7) Gag protein) [Contains: Matrix protein; Capsid protein; Nucleocapsid protein].

GAK4_HUMAN
θ value	8.99809 (rank : 37)	NC score	0.019619 (rank : 24)
Query Neighborhood Hits	40	Target Neighborhood Hits	415	Shared Neighborhood Hits	8
SwissProt Accessions	P63126, Q9UKH4	Gene names
Domain Architecture	No domain graphic available
Description	HERV-K_6q14.1 provirus ancestral Gag polyprotein (Gag polyprotein) (HERV-K109 Gag protein) (HERV-K(C6) Gag protein) [Contains: Matrix protein; Capsid protein; Nucleocapsid protein].

GAK5_HUMAN
θ value	8.99809 (rank : 38)	NC score	0.019551 (rank : 26)
Query Neighborhood Hits	40	Target Neighborhood Hits	429	Shared Neighborhood Hits	8
SwissProt Accessions	P62684	Gene names
Domain Architecture	No domain graphic available
Description	HERV-K_19p13.11 provirus ancestral Gag polyprotein (Gag polyprotein) (HERV-K113 Gag protein) [Contains: Matrix protein; Capsid protein; Nucleocapsid protein].

PIGG_HUMAN
θ value	8.99809 (rank : 39)	NC score	0.014110 (rank : 33)
Query Neighborhood Hits	40	Target Neighborhood Hits	27	Shared Neighborhood Hits	2
SwissProt Accessions	Q5H8A4, Q2TAK5, Q6UX31, Q7L5Y4, Q8N866, Q8NCC9, Q96SY9, Q9BVT7, Q9NXG5	Gene names	PIGG, GPI7
Domain Architecture	No domain graphic available
Description	GPI ethanolamine phosphate transferase 2 (EC 2.-.-.-) (Phosphatidylinositol-glycan biosynthesis class G protein) (PIG-G) (GPI7 homolog) (hGPI7).

TF3C5_HUMAN
θ value	8.99809 (rank : 40)	NC score	0.014003 (rank : 34)
Query Neighborhood Hits	40	Target Neighborhood Hits	8	Shared Neighborhood Hits	2
SwissProt Accessions	Q9Y5Q8, Q8N2U7, Q8N857, Q96GD9, Q9H4P2	Gene names	GTF3C5
Domain Architecture	No domain graphic available
Description	General transcription factor 3C polypeptide 5 (Transcription factor IIIC-epsilon subunit) (TF3C-epsilon) (TFIIIC 63 kDa subunit) (TFIIIC63).

Hits sorted by NC score

DEPD5_HUMAN
NC score	0.999962 (rank : 1)	θ value	0 (rank : 1)
Query Neighborhood Hits	40	Target Neighborhood Hits	40	Shared Neighborhood Hits	40
SwissProt Accessions	O75140, Q5K3V5, Q5THY9, Q5THZ0, Q5THZ1, Q5THZ3, Q68DR1, Q6MZX3, Q6PEZ1, Q9UGV8, Q9UH13	Gene names	DEPDC5, KIAA0645
Domain Architecture
Description	DEP domain-containing protein 5.

DEPD5_MOUSE
NC score	0.992797 (rank : 2)	θ value	0 (rank : 2)
Query Neighborhood Hits	40	Target Neighborhood Hits	32	Shared Neighborhood Hits	18
SwissProt Accessions	P61460	Gene names	Depdc5, Kiaa0645
Domain Architecture
Description	DEP domain-containing protein 5.

DVL3_MOUSE
NC score	0.147649 (rank : 3)	θ value	0.0431538 (rank : 8)
Query Neighborhood Hits	40	Target Neighborhood Hits	198	Shared Neighborhood Hits	13
SwissProt Accessions	Q61062	Gene names	Dvl3
Domain Architecture
Description	Segment polarity protein dishevelled homolog DVL-3 (Dishevelled-3) (DSH homolog 3).

DVL3_HUMAN
NC score	0.147510 (rank : 4)	θ value	0.0431538 (rank : 7)
Query Neighborhood Hits	40	Target Neighborhood Hits	194	Shared Neighborhood Hits	13
SwissProt Accessions	Q92997, O14642, Q13531, Q8N5E9, Q92607	Gene names	DVL3, KIAA0208
Domain Architecture
Description	Segment polarity protein dishevelled homolog DVL-3 (Dishevelled-3) (DSH homolog 3).

DVL1_MOUSE
NC score	0.140351 (rank : 5)	θ value	0.00869519 (rank : 3)
Query Neighborhood Hits	40	Target Neighborhood Hits	146	Shared Neighborhood Hits	13
SwissProt Accessions	P51141, Q60868	Gene names	Dvl1, Dvl
Domain Architecture
Description	Segment polarity protein dishevelled homolog DVL-1 (Dishevelled-1) (DSH homolog 1).

DVL2_HUMAN
NC score	0.137021 (rank : 6)	θ value	0.0330416 (rank : 6)
Query Neighborhood Hits	40	Target Neighborhood Hits	223	Shared Neighborhood Hits	13
SwissProt Accessions	O14641	Gene names	DVL2
Domain Architecture
Description	Segment polarity protein dishevelled homolog DVL-2 (Dishevelled-2) (DSH homolog 2).

DVL1L_HUMAN
NC score	0.134759 (rank : 7)	θ value	0.0330416 (rank : 5)
Query Neighborhood Hits	40	Target Neighborhood Hits	146	Shared Neighborhood Hits	13
SwissProt Accessions	P54792	Gene names	DVL1L1, DVL, DVL1
Domain Architecture
Description	Segment polarity protein dishevelled homolog DVL-1-like (Dishevelled- 1-like) (DSH homolog 1-like).

DVL2_MOUSE
NC score	0.133602 (rank : 8)	θ value	0.0563607 (rank : 10)
Query Neighborhood Hits	40	Target Neighborhood Hits	233	Shared Neighborhood Hits	13
SwissProt Accessions	Q60838	Gene names	Dvl2
Domain Architecture
Description	Segment polarity protein dishevelled homolog DVL-2 (Dishevelled-2) (DSH homolog 2).

DVL1_HUMAN
NC score	0.130581 (rank : 9)	θ value	0.0563607 (rank : 9)
Query Neighborhood Hits	40	Target Neighborhood Hits	158	Shared Neighborhood Hits	12
SwissProt Accessions	O14640	Gene names	DVL1
Domain Architecture
Description	Segment polarity protein dishevelled homolog DVL-1 (Dishevelled-1) (DSH homolog 1).

RPGF4_MOUSE
NC score	0.086152 (rank : 10)	θ value	0.0193708 (rank : 4)
Query Neighborhood Hits	40	Target Neighborhood Hits	80	Shared Neighborhood Hits	14
SwissProt Accessions	Q9EQZ6, Q8VIP9, Q9CW52, Q9Z1P0	Gene names	Rapgef4, Cgef2, Epac2
Domain Architecture
Description	Rap guanine nucleotide exchange factor 4 (cAMP-regulated guanine nucleotide exchange factor II) (cAMP-GEFII) (Exchange factor directly activated by cAMP 2) (Epac 2) (cAMP-dependent Rap1 guanine-nucleotide exchange factor).

FYV1_MOUSE
NC score	0.084397 (rank : 11)	θ value	0.125558 (rank : 11)
Query Neighborhood Hits	40	Target Neighborhood Hits	191	Shared Neighborhood Hits	13
SwissProt Accessions	Q9Z1T6	Gene names	Pip5k3, Pikfyve
Domain Architecture
Description	FYVE finger-containing phosphoinositide kinase (EC 2.7.1.68) (1- phosphatidylinositol-4-phosphate 5-kinase) (PIP5K) (PtdIns(4)P-5- kinase) (PIKfyve) (p235).

FYV1_HUMAN
NC score	0.084026 (rank : 12)	θ value	0.163984 (rank : 12)
Query Neighborhood Hits	40	Target Neighborhood Hits	217	Shared Neighborhood Hits	14
SwissProt Accessions	Q9Y2I7, Q8NB67	Gene names	PIP5K3, KIAA0981, PIKFYVE
Domain Architecture
Description	FYVE finger-containing phosphoinositide kinase (EC 2.7.1.68) (1- phosphatidylinositol-4-phosphate 5-kinase) (Phosphatidylinositol-3- phosphate 5-kinase type III) (PIP5K) (PtdIns(4)P-5-kinase) (PIKfyve) (p235).

RPGF4_HUMAN
NC score	0.077563 (rank : 13)	θ value	0.163984 (rank : 13)
Query Neighborhood Hits	40	Target Neighborhood Hits	88	Shared Neighborhood Hits	12
SwissProt Accessions	Q8WZA2, O95636, Q8IXK6, Q8TAA4	Gene names	RAPGEF4, CGEF2, EPAC2
Domain Architecture
Description	Rap guanine nucleotide exchange factor 4 (cAMP-regulated guanine nucleotide exchange factor II) (cAMP-GEFII) (Exchange factor directly activated by cAMP 2) (Epac 2).

RPGF5_MOUSE
NC score	0.058509 (rank : 14)	θ value	0.62314 (rank : 15)
Query Neighborhood Hits	40	Target Neighborhood Hits	85	Shared Neighborhood Hits	11
SwissProt Accessions	Q8C0Q9, Q8BJJ9, Q8C0R5	Gene names	Rapgef5, Gfr, Kiaa0277, Mrgef
Domain Architecture
Description	Rap guanine nucleotide exchange factor 5 (Guanine nucleotide exchange factor for Rap1) (M-Ras-regulated Rap GEF) (MR-GEF).

RNZ1_MOUSE
NC score	0.055305 (rank : 15)	θ value	2.36792 (rank : 20)
Query Neighborhood Hits	40	Target Neighborhood Hits	8	Shared Neighborhood Hits	4
SwissProt Accessions	Q8VEB6, Q9CXB1, Q9ERF4	Gene names	Elac1
Domain Architecture
Description	Zinc phosphodiesterase ELAC protein 1 (EC 3.1.26.11) (Ribonuclease Z 1) (RNase Z 1) (tRNase Z 1) (tRNA 3 endonuclease 1) (ElaC homolog protein 1).

RNZ1_HUMAN
NC score	0.055032 (rank : 16)	θ value	2.36792 (rank : 19)
Query Neighborhood Hits	40	Target Neighborhood Hits	12	Shared Neighborhood Hits	4
SwissProt Accessions	Q9H777, Q9NS99	Gene names	ELAC1, D29
Domain Architecture
Description	Zinc phosphodiesterase ELAC protein 1 (EC 3.1.26.11) (Ribonuclease Z 1) (RNase Z 1) (tRNase Z 1) (tRNA 3 endonuclease 1) (ElaC homolog protein 1) (Deleted in Ma29).

NICA_HUMAN
NC score	0.031140 (rank : 17)	θ value	1.81305 (rank : 17)
Query Neighborhood Hits	40	Target Neighborhood Hits	14	Shared Neighborhood Hits	2
SwissProt Accessions	Q92542, Q86VV5	Gene names	NCSTN, KIAA0253
Domain Architecture
Description	Nicastrin precursor.

BMP10_MOUSE
NC score	0.027219 (rank : 18)	θ value	0.365318 (rank : 14)
Query Neighborhood Hits	40	Target Neighborhood Hits	75	Shared Neighborhood Hits	3
SwissProt Accessions	Q9R229, Q9Z1V8	Gene names	Bmp10
Domain Architecture
Description	Bone morphogenetic protein 10 precursor (BMP-10).

NFAT5_MOUSE
NC score	0.021726 (rank : 19)	θ value	3.0926 (rank : 23)
Query Neighborhood Hits	40	Target Neighborhood Hits	162	Shared Neighborhood Hits	4
SwissProt Accessions	Q9WV30	Gene names	Nfat5
Domain Architecture
Description	Nuclear factor of activated T-cells 5 (T cell transcription factor NFAT5) (NF-AT5) (Rel domain-containing transcription factor NFAT5).

GAK6_HUMAN
NC score	0.021548 (rank : 20)	θ value	4.03905 (rank : 24)
Query Neighborhood Hits	40	Target Neighborhood Hits	392	Shared Neighborhood Hits	8
SwissProt Accessions	P62685	Gene names
Domain Architecture	No domain graphic available
Description	HERV-K_8p23.1 provirus ancestral Gag polyprotein (Gag polyprotein) (HERV-K115 Gag protein) [Contains: Matrix protein; Capsid protein; Nucleocapsid protein].

GAK1_HUMAN
NC score	0.020128 (rank : 21)	θ value	8.99809 (rank : 35)
Query Neighborhood Hits	40	Target Neighborhood Hits	268	Shared Neighborhood Hits	8
SwissProt Accessions	P62683	Gene names
Domain Architecture	No domain graphic available
Description	HERV-K_12q14.1 provirus ancestral Gag polyprotein (Gag polyprotein) [Contains: Matrix protein; Capsid protein; Nucleocapsid protein].

GAK12_HUMAN
NC score	0.019808 (rank : 22)	θ value	8.99809 (rank : 34)
Query Neighborhood Hits	40	Target Neighborhood Hits	374	Shared Neighborhood Hits	8
SwissProt Accessions	P63130, Q9UKI0	Gene names
Domain Architecture	No domain graphic available
Description	HERV-K_1q22 provirus ancestral Gag polyprotein (Gag polyprotein) (HERV-K102 Gag protein) (HERV-K(III) Gag protein) [Contains: Matrix protein; Capsid protein; Nucleocapsid protein].

GAK2_HUMAN
NC score	0.019627 (rank : 23)	θ value	8.99809 (rank : 36)
Query Neighborhood Hits	40	Target Neighborhood Hits	406	Shared Neighborhood Hits	8
SwissProt Accessions	Q7LDI9, Q9UKH5, Q9Y6I1, Q9YNA6, Q9YNB0	Gene names	ERVK6
Domain Architecture	No domain graphic available
Description	HERV-K_7p22.1 provirus ancestral Gag polyprotein (Gag polyprotein) (HERV-K(HML-2.HOM) Gag protein) (HERV-K108 Gag protein) (HERV-K(C7) Gag protein) [Contains: Matrix protein; Capsid protein; Nucleocapsid protein].

GAK4_HUMAN
NC score	0.019619 (rank : 24)	θ value	8.99809 (rank : 37)
Query Neighborhood Hits	40	Target Neighborhood Hits	415	Shared Neighborhood Hits	8
SwissProt Accessions	P63126, Q9UKH4	Gene names
Domain Architecture	No domain graphic available
Description	HERV-K_6q14.1 provirus ancestral Gag polyprotein (Gag polyprotein) (HERV-K109 Gag protein) (HERV-K(C6) Gag protein) [Contains: Matrix protein; Capsid protein; Nucleocapsid protein].

GAK11_HUMAN
NC score	0.019604 (rank : 25)	θ value	8.99809 (rank : 33)
Query Neighborhood Hits	40	Target Neighborhood Hits	409	Shared Neighborhood Hits	8
SwissProt Accessions	P63145, Q9UKI1	Gene names
Domain Architecture	No domain graphic available
Description	HERV-K_22q11.21 provirus ancestral Gag polyprotein (Gag polyprotein) (HERV-K101 Gag protein) [Contains: Matrix protein; Capsid protein; Nucleocapsid protein].

GAK5_HUMAN
NC score	0.019551 (rank : 26)	θ value	8.99809 (rank : 38)
Query Neighborhood Hits	40	Target Neighborhood Hits	429	Shared Neighborhood Hits	8
SwissProt Accessions	P62684	Gene names
Domain Architecture	No domain graphic available
Description	HERV-K_19p13.11 provirus ancestral Gag polyprotein (Gag polyprotein) (HERV-K113 Gag protein) [Contains: Matrix protein; Capsid protein; Nucleocapsid protein].

STAU2_HUMAN
NC score	0.018356 (rank : 27)	θ value	6.88961 (rank : 31)
Query Neighborhood Hits	40	Target Neighborhood Hits	34	Shared Neighborhood Hits	3
SwissProt Accessions	Q9NUL3, Q6AHY7, Q96HM0, Q96HM1, Q9NVI5, Q9UGG6	Gene names	STAU2
Domain Architecture	No domain graphic available
Description	Double-stranded RNA-binding protein Staufen homolog 2.

STAU2_MOUSE
NC score	0.018219 (rank : 28)	θ value	6.88961 (rank : 32)
Query Neighborhood Hits	40	Target Neighborhood Hits	35	Shared Neighborhood Hits	3
SwissProt Accessions	Q8CJ67, Q8BSY8, Q8CJ66, Q8R175, Q91Z19, Q9D5N7	Gene names	Stau2
Domain Architecture	No domain graphic available
Description	Double-stranded RNA-binding protein Staufen homolog 2.

KLDC4_HUMAN
NC score	0.015304 (rank : 29)	θ value	6.88961 (rank : 28)
Query Neighborhood Hits	40	Target Neighborhood Hits	46	Shared Neighborhood Hits	4
SwissProt Accessions	Q8TBB5, Q96F29, Q9BVN3	Gene names	KLHDC4
Domain Architecture	No domain graphic available
Description	Kelch domain-containing protein 4.

DMD_HUMAN
NC score	0.014404 (rank : 30)	θ value	2.36792 (rank : 18)
Query Neighborhood Hits	40	Target Neighborhood Hits	1135	Shared Neighborhood Hits	6
SwissProt Accessions	P11532, Q02295, Q14169, Q14170, Q5JYU0, Q7KZ48	Gene names	DMD
Domain Architecture
Description	Dystrophin.

SMOO_HUMAN
NC score	0.014299 (rank : 31)	θ value	6.88961 (rank : 30)
Query Neighborhood Hits	40	Target Neighborhood Hits	391	Shared Neighborhood Hits	4
SwissProt Accessions	P53814, O00569, O95769, O95937, Q9P1S8, Q9UIT1, Q9UIT2	Gene names	SMTN, SMSMO
Domain Architecture
Description	Smoothelin.

DMD_MOUSE
NC score	0.014250 (rank : 32)	θ value	1.81305 (rank : 16)
Query Neighborhood Hits	40	Target Neighborhood Hits	1111	Shared Neighborhood Hits	7
SwissProt Accessions	P11531, O35653, Q60703	Gene names	Dmd
Domain Architecture
Description	Dystrophin.

PIGG_HUMAN
NC score	0.014110 (rank : 33)	θ value	8.99809 (rank : 39)
Query Neighborhood Hits	40	Target Neighborhood Hits	27	Shared Neighborhood Hits	2
SwissProt Accessions	Q5H8A4, Q2TAK5, Q6UX31, Q7L5Y4, Q8N866, Q8NCC9, Q96SY9, Q9BVT7, Q9NXG5	Gene names	PIGG, GPI7
Domain Architecture	No domain graphic available
Description	GPI ethanolamine phosphate transferase 2 (EC 2.-.-.-) (Phosphatidylinositol-glycan biosynthesis class G protein) (PIG-G) (GPI7 homolog) (hGPI7).

TF3C5_HUMAN
NC score	0.014003 (rank : 34)	θ value	8.99809 (rank : 40)
Query Neighborhood Hits	40	Target Neighborhood Hits	8	Shared Neighborhood Hits	2
SwissProt Accessions	Q9Y5Q8, Q8N2U7, Q8N857, Q96GD9, Q9H4P2	Gene names	GTF3C5
Domain Architecture	No domain graphic available
Description	General transcription factor 3C polypeptide 5 (Transcription factor IIIC-epsilon subunit) (TF3C-epsilon) (TFIIIC 63 kDa subunit) (TFIIIC63).

KIF2C_MOUSE
NC score	0.009501 (rank : 35)	θ value	4.03905 (rank : 25)
Query Neighborhood Hits	40	Target Neighborhood Hits	96	Shared Neighborhood Hits	3
SwissProt Accessions	Q922S8	Gene names	Kif2c
Domain Architecture
Description	Kinesin-like protein KIF2C (Mitotic centromere-associated kinesin) (MCAK).

CENPE_HUMAN
NC score	0.008070 (rank : 36)	θ value	3.0926 (rank : 21)
Query Neighborhood Hits	40	Target Neighborhood Hits	2060	Shared Neighborhood Hits	7
SwissProt Accessions	Q02224	Gene names	CENPE
Domain Architecture
Description	Centromeric protein E (CENP-E).

CEL_MOUSE
NC score	0.007469 (rank : 37)	θ value	6.88961 (rank : 27)
Query Neighborhood Hits	40	Target Neighborhood Hits	28	Shared Neighborhood Hits	2
SwissProt Accessions	Q64285	Gene names	Cel, Lip1
Domain Architecture
Description	Bile salt-activated lipase precursor (EC 3.1.1.3) (EC 3.1.1.13) (BAL) (Bile salt-stimulated lipase) (BSSL) (Carboxyl ester lipase) (Sterol esterase) (Cholesterol esterase) (Pancreatic lysophospholipase).

LTBP4_MOUSE
NC score	0.004778 (rank : 38)	θ value	4.03905 (rank : 26)
Query Neighborhood Hits	40	Target Neighborhood Hits	607	Shared Neighborhood Hits	2
SwissProt Accessions	Q8K4G1, Q8K4G0	Gene names	Ltbp4
Domain Architecture
Description	Latent-transforming growth factor beta-binding protein 4 precursor (LTBP-4).

KSYK_MOUSE
NC score	0.003421 (rank : 39)	θ value	3.0926 (rank : 22)
Query Neighborhood Hits	40	Target Neighborhood Hits	944	Shared Neighborhood Hits	4
SwissProt Accessions	P48025	Gene names	Syk
Domain Architecture
Description	Tyrosine-protein kinase SYK (EC 2.7.10.2) (Spleen tyrosine kinase).

KSYK_HUMAN
NC score	0.002541 (rank : 40)	θ value	6.88961 (rank : 29)
Query Neighborhood Hits	40	Target Neighborhood Hits	901	Shared Neighborhood Hits	4
SwissProt Accessions	P43405	Gene names	SYK
Domain Architecture
Description	Tyrosine-protein kinase SYK (EC 2.7.10.2) (Spleen tyrosine kinase).