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Network neighborhood for query Sequence : RAE1_HUMAN

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RAE1_HUMAN
 
SwissProt Accessions P24386, O43732 Gene names CHM, REP1, TCD
Domain
Architecture
Description Rab proteins geranylgeranyltransferase component A 1 (Rab escort protein 1) (REP-1) (Choroideraemia protein) (TCD protein).
Rank Plots



Hits sorted by θ


RAE1_HUMAN
 
θ value 0 (rank : 1) NC score 0.999962 (rank : 1)
Query Neighborhood Hits 25 Target Neighborhood Hits 25 Shared Neighborhood Hits 25
SwissProt Accessions P24386, O43732 Gene names CHM, REP1, TCD
Domain
Architecture
Description Rab proteins geranylgeranyltransferase component A 1 (Rab escort protein 1) (REP-1) (Choroideraemia protein) (TCD protein).
RAE1_MOUSE
 
θ value 0 (rank : 2) NC score 0.993399 (rank : 3)
Query Neighborhood Hits 25 Target Neighborhood Hits 32 Shared Neighborhood Hits 11
SwissProt Accessions Q9QXG2, Q80UV8 Gene names Chm, Rep1
Domain
Architecture
Description Rab proteins geranylgeranyltransferase component A 1 (Rab escort protein 1) (REP-1) (Choroideraemia protein homolog).
RAE2_HUMAN
 
θ value 0 (rank : 3) NC score 0.994185 (rank : 2)
Query Neighborhood Hits 25 Target Neighborhood Hits 26 Shared Neighborhood Hits 10
SwissProt Accessions P26374, Q9H1Y4 Gene names CHML, REP2
Domain
Architecture
Description Rab proteins geranylgeranyltransferase component A 2 (Rab escort protein 2) (REP-2) (Choroideraemia-like protein).
RAE2_MOUSE
 
θ value 0 (rank : 4) NC score 0.986722 (rank : 4)
Query Neighborhood Hits 25 Target Neighborhood Hits 53 Shared Neighborhood Hits 11
SwissProt Accessions Q9QZD5, Q8CH16 Gene names Chml, Rep2
Domain
Architecture
Description Rab proteins geranylgeranyltransferase component A 2 (Rab escort protein 2) (REP-2) (Choroideraemia-like protein).
GDIB_MOUSE
 
θ value 8.08199e-25 (rank : 5) NC score 0.693832 (rank : 5)
Query Neighborhood Hits 25 Target Neighborhood Hits 17 Shared Neighborhood Hits 10
SwissProt Accessions Q61598, Q541Z9, Q8C530, Q9D8M9 Gene names Gdi2, Gdi3
Domain
Architecture
Description Rab GDP dissociation inhibitor beta (Rab GDI beta) (Guanosine diphosphate dissociation inhibitor 2) (GDI-2) (GDI-3).
GDIA_MOUSE
 
θ value 1.05554e-24 (rank : 6) NC score 0.691916 (rank : 6)
Query Neighborhood Hits 25 Target Neighborhood Hits 13 Shared Neighborhood Hits 9
SwissProt Accessions P50396, Q8VHM3, Q91Y71, Q96CX5 Gene names Gdi1, Rabgdia
Domain
Architecture
Description Rab GDP dissociation inhibitor alpha (Rab GDI alpha) (Guanosine diphosphate dissociation inhibitor 1) (GDI-1).
GDIA_HUMAN
 
θ value 4.01107e-24 (rank : 7) NC score 0.690210 (rank : 7)
Query Neighborhood Hits 25 Target Neighborhood Hits 14 Shared Neighborhood Hits 9
SwissProt Accessions P31150, P50394, Q7Z2G6, Q7Z2G9, Q7Z2H5, Q7Z2I6 Gene names GDI1, OPHN2, RABGDIA, XAP4
Domain
Architecture
Description Rab GDP dissociation inhibitor alpha (Rab GDI alpha) (Guanosine diphosphate dissociation inhibitor 1) (GDI-1) (XAP-4) (Oligophrenin- 2).
GDIB_HUMAN
 
θ value 4.01107e-24 (rank : 8) NC score 0.687877 (rank : 8)
Query Neighborhood Hits 25 Target Neighborhood Hits 14 Shared Neighborhood Hits 9
SwissProt Accessions P50395, O43928, Q9UQM6 Gene names GDI2, RABGDIB
Domain
Architecture
Description Rab GDP dissociation inhibitor beta (Rab GDI beta) (Guanosine diphosphate dissociation inhibitor 2) (GDI-2).
RETST_HUMAN
 
θ value 0.0252991 (rank : 9) NC score 0.164207 (rank : 9)
Query Neighborhood Hits 25 Target Neighborhood Hits 27 Shared Neighborhood Hits 10
SwissProt Accessions Q6NUM9, Q53R95, Q53SA9, Q6UX05, Q8N2H5, Q96FA4, Q9NXE5 Gene names RETSAT
Domain
Architecture

No domain graphic available

Description All-trans-retinol 13,14-reductase precursor (EC 1.3.99.23) (All-trans- 13,14-dihydroretinol saturase) (RetSat).
ARHGC_MOUSE
 
θ value 0.0431538 (rank : 10) NC score 0.029631 (rank : 11)
Query Neighborhood Hits 25 Target Neighborhood Hits 344 Shared Neighborhood Hits 3
SwissProt Accessions Q8R4H2, Q80U18 Gene names Arhgef12, Kiaa0382, Larg
Domain
Architecture
Description Rho guanine nucleotide exchange factor 12 (Leukemia-associated RhoGEF).
RETST_MOUSE
 
θ value 0.125558 (rank : 11) NC score 0.132750 (rank : 10)
Query Neighborhood Hits 25 Target Neighborhood Hits 26 Shared Neighborhood Hits 7
SwissProt Accessions Q64FW2, Q3UNN9, Q78JX8, Q8VHE7, Q9CW85 Gene names Retsat
Domain
Architecture

No domain graphic available

Description All-trans-retinol 13,14-reductase precursor (EC 1.3.99.23) (All-trans- 13,14-dihydroretinol saturase) (RetSat).
SLK_MOUSE
 
θ value 0.62314 (rank : 12) NC score 0.001625 (rank : 24)
Query Neighborhood Hits 25 Target Neighborhood Hits 1798 Shared Neighborhood Hits 4
SwissProt Accessions O54988, Q80U65, Q8CAU2, Q8CDW2, Q9WU41 Gene names Slk, Kiaa0204, Stk2
Domain
Architecture

No domain graphic available

Description STE20-like serine/threonine-protein kinase (EC 2.7.11.1) (STE20-like kinase) (STE20-related serine/threonine-protein kinase) (STE20-related kinase) (mSLK) (Serine/threonine-protein kinase 2) (STE20-related kinase SMAK) (Etk4).
WWP1_HUMAN
 
θ value 0.62314 (rank : 13) NC score 0.011779 (rank : 19)
Query Neighborhood Hits 25 Target Neighborhood Hits 262 Shared Neighborhood Hits 4
SwissProt Accessions Q9H0M0, O00307, Q96BP4 Gene names WWP1
Domain
Architecture
Description NEDD4-like E3 ubiquitin-protein ligase WWP1 (EC 6.3.2.-) (WW domain- containing protein 1) (Atropin-1-interacting protein 5) (AIP5).
EDEM3_HUMAN
 
θ value 1.38821 (rank : 14) NC score 0.019172 (rank : 15)
Query Neighborhood Hits 25 Target Neighborhood Hits 92 Shared Neighborhood Hits 4
SwissProt Accessions Q9BZQ6, Q5TEZ0, Q9HCW1, Q9UFV7 Gene names EDEM3, C1orf22
Domain
Architecture
Description ER degradation-enhancing alpha-mannosidase-like 3.
ZN638_HUMAN
 
θ value 1.38821 (rank : 15) NC score 0.021328 (rank : 14)
Query Neighborhood Hits 25 Target Neighborhood Hits 343 Shared Neighborhood Hits 4
SwissProt Accessions Q14966, Q53R34, Q5XJ05, Q68DP3, Q6P2H2, Q7Z3T7, Q8NF92, Q8TCA1, Q9H2G1, Q9NP37 Gene names ZNF638, NP220, ZFML
Domain
Architecture

No domain graphic available

Description Zinc finger protein 638 (Nuclear protein 220) (Zinc-finger matrin-like protein) (Cutaneous T-cell lymphoma-associated antigen se33-1) (CTCL tumor antigen se33-1).
ZN318_MOUSE
 
θ value 1.81305 (rank : 16) NC score 0.017942 (rank : 16)
Query Neighborhood Hits 25 Target Neighborhood Hits 642 Shared Neighborhood Hits 5
SwissProt Accessions Q99PP2, Q3TZL5, Q9JJ01 Gene names Znf318, Tzf, Zfp318
Domain
Architecture

No domain graphic available

Description Zinc finger protein 318 (Testicular zinc finger protein).
RANB3_HUMAN
 
θ value 2.36792 (rank : 17) NC score 0.021608 (rank : 12)
Query Neighborhood Hits 25 Target Neighborhood Hits 117 Shared Neighborhood Hits 2
SwissProt Accessions Q9H6Z4, O60405, O75759, O75760, Q9BT47, Q9UG74 Gene names RANBP3
Domain
Architecture

No domain graphic available

Description Ran-binding protein 3 (RanBP3).
ARHGC_HUMAN
 
θ value 4.03905 (rank : 18) NC score 0.021501 (rank : 13)
Query Neighborhood Hits 25 Target Neighborhood Hits 351 Shared Neighborhood Hits 3
SwissProt Accessions Q9NZN5, O15086 Gene names ARHGEF12, KIAA0382, LARG
Domain
Architecture
Description Rho guanine nucleotide exchange factor 12 (Leukemia-associated RhoGEF).
DSPP_HUMAN
 
θ value 5.27518 (rank : 19) NC score 0.016161 (rank : 17)
Query Neighborhood Hits 25 Target Neighborhood Hits 645 Shared Neighborhood Hits 10
SwissProt Accessions Q9NZW4, O95815 Gene names DSPP
Domain
Architecture

No domain graphic available

Description Dentin sialophosphoprotein precursor [Contains: Dentin phosphoprotein (Dentin phosphophoryn) (DPP); Dentin sialoprotein (DSP)].
IWS1_HUMAN
 
θ value 6.88961 (rank : 20) NC score 0.005614 (rank : 22)
Query Neighborhood Hits 25 Target Neighborhood Hits 1241 Shared Neighborhood Hits 6
SwissProt Accessions Q96ST2, Q6P157, Q8N3E8, Q96MI7, Q9NV97, Q9NWH8 Gene names IWS1, IWS1L
Domain
Architecture

No domain graphic available

Description IWS1 homolog (IWS1-like protein).
ZFY1_MOUSE
 
θ value 6.88961 (rank : 21) NC score -0.000883 (rank : 25)
Query Neighborhood Hits 25 Target Neighborhood Hits 790 Shared Neighborhood Hits 3
SwissProt Accessions P10925 Gene names Zfy1, Zfy-1
Domain
Architecture
Description Zinc finger Y-chromosomal protein 1.
MORN3_MOUSE
 
θ value 8.99809 (rank : 22) NC score 0.013176 (rank : 18)
Query Neighborhood Hits 25 Target Neighborhood Hits 25 Shared Neighborhood Hits 3
SwissProt Accessions Q8C5T4, Q8VE21, Q9D5H6 Gene names Morn3
Domain
Architecture

No domain graphic available

Description MORN repeat-containing protein 3.
PACS1_MOUSE
 
θ value 8.99809 (rank : 23) NC score 0.010235 (rank : 20)
Query Neighborhood Hits 25 Target Neighborhood Hits 87 Shared Neighborhood Hits 3
SwissProt Accessions Q8K212, Q6P5H8 Gene names Pacs1
Domain
Architecture

No domain graphic available

Description Phosphofurin acidic cluster sorting protein 1 (PACS-1).
S12A6_MOUSE
 
θ value 8.99809 (rank : 24) NC score 0.004297 (rank : 23)
Query Neighborhood Hits 25 Target Neighborhood Hits 67 Shared Neighborhood Hits 2
SwissProt Accessions Q924N4, Q924N3 Gene names Slc12a6, Kcc3
Domain
Architecture
Description Solute carrier family 12 member 6 (Electroneutral potassium-chloride cotransporter 3) (K-Cl cotransporter 3).
UBXD2_MOUSE
 
θ value 8.99809 (rank : 25) NC score 0.010060 (rank : 21)
Query Neighborhood Hits 25 Target Neighborhood Hits 183 Shared Neighborhood Hits 4
SwissProt Accessions Q8VCH8, Q8BW17 Gene names Ubxd2, Ubxdc1
Domain
Architecture
Description UBX domain-containing protein 2.

Hits sorted by NC score


RAE1_HUMAN
 
NC score 0.999962 (rank : 1) θ value 0 (rank : 1)
Query Neighborhood Hits 25 Target Neighborhood Hits 25 Shared Neighborhood Hits 25
SwissProt Accessions P24386, O43732 Gene names CHM, REP1, TCD
Domain
Architecture
Description Rab proteins geranylgeranyltransferase component A 1 (Rab escort protein 1) (REP-1) (Choroideraemia protein) (TCD protein).
RAE2_HUMAN
 
NC score 0.994185 (rank : 2) θ value 0 (rank : 3)
Query Neighborhood Hits 25 Target Neighborhood Hits 26 Shared Neighborhood Hits 10
SwissProt Accessions P26374, Q9H1Y4 Gene names CHML, REP2
Domain
Architecture
Description Rab proteins geranylgeranyltransferase component A 2 (Rab escort protein 2) (REP-2) (Choroideraemia-like protein).
RAE1_MOUSE
 
NC score 0.993399 (rank : 3) θ value 0 (rank : 2)
Query Neighborhood Hits 25 Target Neighborhood Hits 32 Shared Neighborhood Hits 11
SwissProt Accessions Q9QXG2, Q80UV8 Gene names Chm, Rep1
Domain
Architecture
Description Rab proteins geranylgeranyltransferase component A 1 (Rab escort protein 1) (REP-1) (Choroideraemia protein homolog).
RAE2_MOUSE
 
NC score 0.986722 (rank : 4) θ value 0 (rank : 4)
Query Neighborhood Hits 25 Target Neighborhood Hits 53 Shared Neighborhood Hits 11
SwissProt Accessions Q9QZD5, Q8CH16 Gene names Chml, Rep2
Domain
Architecture
Description Rab proteins geranylgeranyltransferase component A 2 (Rab escort protein 2) (REP-2) (Choroideraemia-like protein).
GDIB_MOUSE
 
NC score 0.693832 (rank : 5) θ value 8.08199e-25 (rank : 5)
Query Neighborhood Hits 25 Target Neighborhood Hits 17 Shared Neighborhood Hits 10
SwissProt Accessions Q61598, Q541Z9, Q8C530, Q9D8M9 Gene names Gdi2, Gdi3
Domain
Architecture
Description Rab GDP dissociation inhibitor beta (Rab GDI beta) (Guanosine diphosphate dissociation inhibitor 2) (GDI-2) (GDI-3).
GDIA_MOUSE
 
NC score 0.691916 (rank : 6) θ value 1.05554e-24 (rank : 6)
Query Neighborhood Hits 25 Target Neighborhood Hits 13 Shared Neighborhood Hits 9
SwissProt Accessions P50396, Q8VHM3, Q91Y71, Q96CX5 Gene names Gdi1, Rabgdia
Domain
Architecture
Description Rab GDP dissociation inhibitor alpha (Rab GDI alpha) (Guanosine diphosphate dissociation inhibitor 1) (GDI-1).
GDIA_HUMAN
 
NC score 0.690210 (rank : 7) θ value 4.01107e-24 (rank : 7)
Query Neighborhood Hits 25 Target Neighborhood Hits 14 Shared Neighborhood Hits 9
SwissProt Accessions P31150, P50394, Q7Z2G6, Q7Z2G9, Q7Z2H5, Q7Z2I6 Gene names GDI1, OPHN2, RABGDIA, XAP4
Domain
Architecture
Description Rab GDP dissociation inhibitor alpha (Rab GDI alpha) (Guanosine diphosphate dissociation inhibitor 1) (GDI-1) (XAP-4) (Oligophrenin- 2).
GDIB_HUMAN
 
NC score 0.687877 (rank : 8) θ value 4.01107e-24 (rank : 8)
Query Neighborhood Hits 25 Target Neighborhood Hits 14 Shared Neighborhood Hits 9
SwissProt Accessions P50395, O43928, Q9UQM6 Gene names GDI2, RABGDIB
Domain
Architecture
Description Rab GDP dissociation inhibitor beta (Rab GDI beta) (Guanosine diphosphate dissociation inhibitor 2) (GDI-2).
RETST_HUMAN
 
NC score 0.164207 (rank : 9) θ value 0.0252991 (rank : 9)
Query Neighborhood Hits 25 Target Neighborhood Hits 27 Shared Neighborhood Hits 10
SwissProt Accessions Q6NUM9, Q53R95, Q53SA9, Q6UX05, Q8N2H5, Q96FA4, Q9NXE5 Gene names RETSAT
Domain
Architecture

No domain graphic available

Description All-trans-retinol 13,14-reductase precursor (EC 1.3.99.23) (All-trans- 13,14-dihydroretinol saturase) (RetSat).
RETST_MOUSE
 
NC score 0.132750 (rank : 10) θ value 0.125558 (rank : 11)
Query Neighborhood Hits 25 Target Neighborhood Hits 26 Shared Neighborhood Hits 7
SwissProt Accessions Q64FW2, Q3UNN9, Q78JX8, Q8VHE7, Q9CW85 Gene names Retsat
Domain
Architecture

No domain graphic available

Description All-trans-retinol 13,14-reductase precursor (EC 1.3.99.23) (All-trans- 13,14-dihydroretinol saturase) (RetSat).
ARHGC_MOUSE
 
NC score 0.029631 (rank : 11) θ value 0.0431538 (rank : 10)
Query Neighborhood Hits 25 Target Neighborhood Hits 344 Shared Neighborhood Hits 3
SwissProt Accessions Q8R4H2, Q80U18 Gene names Arhgef12, Kiaa0382, Larg
Domain
Architecture
Description Rho guanine nucleotide exchange factor 12 (Leukemia-associated RhoGEF).
RANB3_HUMAN
 
NC score 0.021608 (rank : 12) θ value 2.36792 (rank : 17)
Query Neighborhood Hits 25 Target Neighborhood Hits 117 Shared Neighborhood Hits 2
SwissProt Accessions Q9H6Z4, O60405, O75759, O75760, Q9BT47, Q9UG74 Gene names RANBP3
Domain
Architecture

No domain graphic available

Description Ran-binding protein 3 (RanBP3).
ARHGC_HUMAN
 
NC score 0.021501 (rank : 13) θ value 4.03905 (rank : 18)
Query Neighborhood Hits 25 Target Neighborhood Hits 351 Shared Neighborhood Hits 3
SwissProt Accessions Q9NZN5, O15086 Gene names ARHGEF12, KIAA0382, LARG
Domain
Architecture
Description Rho guanine nucleotide exchange factor 12 (Leukemia-associated RhoGEF).
ZN638_HUMAN
 
NC score 0.021328 (rank : 14) θ value 1.38821 (rank : 15)
Query Neighborhood Hits 25 Target Neighborhood Hits 343 Shared Neighborhood Hits 4
SwissProt Accessions Q14966, Q53R34, Q5XJ05, Q68DP3, Q6P2H2, Q7Z3T7, Q8NF92, Q8TCA1, Q9H2G1, Q9NP37 Gene names ZNF638, NP220, ZFML
Domain
Architecture

No domain graphic available

Description Zinc finger protein 638 (Nuclear protein 220) (Zinc-finger matrin-like protein) (Cutaneous T-cell lymphoma-associated antigen se33-1) (CTCL tumor antigen se33-1).
EDEM3_HUMAN
 
NC score 0.019172 (rank : 15) θ value 1.38821 (rank : 14)
Query Neighborhood Hits 25 Target Neighborhood Hits 92 Shared Neighborhood Hits 4
SwissProt Accessions Q9BZQ6, Q5TEZ0, Q9HCW1, Q9UFV7 Gene names EDEM3, C1orf22
Domain
Architecture
Description ER degradation-enhancing alpha-mannosidase-like 3.
ZN318_MOUSE
 
NC score 0.017942 (rank : 16) θ value 1.81305 (rank : 16)
Query Neighborhood Hits 25 Target Neighborhood Hits 642 Shared Neighborhood Hits 5
SwissProt Accessions Q99PP2, Q3TZL5, Q9JJ01 Gene names Znf318, Tzf, Zfp318
Domain
Architecture

No domain graphic available

Description Zinc finger protein 318 (Testicular zinc finger protein).
DSPP_HUMAN
 
NC score 0.016161 (rank : 17) θ value 5.27518 (rank : 19)
Query Neighborhood Hits 25 Target Neighborhood Hits 645 Shared Neighborhood Hits 10
SwissProt Accessions Q9NZW4, O95815 Gene names DSPP
Domain
Architecture

No domain graphic available

Description Dentin sialophosphoprotein precursor [Contains: Dentin phosphoprotein (Dentin phosphophoryn) (DPP); Dentin sialoprotein (DSP)].
MORN3_MOUSE
 
NC score 0.013176 (rank : 18) θ value 8.99809 (rank : 22)
Query Neighborhood Hits 25 Target Neighborhood Hits 25 Shared Neighborhood Hits 3
SwissProt Accessions Q8C5T4, Q8VE21, Q9D5H6 Gene names Morn3
Domain
Architecture

No domain graphic available

Description MORN repeat-containing protein 3.
WWP1_HUMAN
 
NC score 0.011779 (rank : 19) θ value 0.62314 (rank : 13)
Query Neighborhood Hits 25 Target Neighborhood Hits 262 Shared Neighborhood Hits 4
SwissProt Accessions Q9H0M0, O00307, Q96BP4 Gene names WWP1
Domain
Architecture
Description NEDD4-like E3 ubiquitin-protein ligase WWP1 (EC 6.3.2.-) (WW domain- containing protein 1) (Atropin-1-interacting protein 5) (AIP5).
PACS1_MOUSE
 
NC score 0.010235 (rank : 20) θ value 8.99809 (rank : 23)
Query Neighborhood Hits 25 Target Neighborhood Hits 87 Shared Neighborhood Hits 3
SwissProt Accessions Q8K212, Q6P5H8 Gene names Pacs1
Domain
Architecture

No domain graphic available

Description Phosphofurin acidic cluster sorting protein 1 (PACS-1).
UBXD2_MOUSE
 
NC score 0.010060 (rank : 21) θ value 8.99809 (rank : 25)
Query Neighborhood Hits 25 Target Neighborhood Hits 183 Shared Neighborhood Hits 4
SwissProt Accessions Q8VCH8, Q8BW17 Gene names Ubxd2, Ubxdc1
Domain
Architecture
Description UBX domain-containing protein 2.
IWS1_HUMAN
 
NC score 0.005614 (rank : 22) θ value 6.88961 (rank : 20)
Query Neighborhood Hits 25 Target Neighborhood Hits 1241 Shared Neighborhood Hits 6
SwissProt Accessions Q96ST2, Q6P157, Q8N3E8, Q96MI7, Q9NV97, Q9NWH8 Gene names IWS1, IWS1L
Domain
Architecture

No domain graphic available

Description IWS1 homolog (IWS1-like protein).
S12A6_MOUSE
 
NC score 0.004297 (rank : 23) θ value 8.99809 (rank : 24)
Query Neighborhood Hits 25 Target Neighborhood Hits 67 Shared Neighborhood Hits 2
SwissProt Accessions Q924N4, Q924N3 Gene names Slc12a6, Kcc3
Domain
Architecture
Description Solute carrier family 12 member 6 (Electroneutral potassium-chloride cotransporter 3) (K-Cl cotransporter 3).
SLK_MOUSE
 
NC score 0.001625 (rank : 24) θ value 0.62314 (rank : 12)
Query Neighborhood Hits 25 Target Neighborhood Hits 1798 Shared Neighborhood Hits 4
SwissProt Accessions O54988, Q80U65, Q8CAU2, Q8CDW2, Q9WU41 Gene names Slk, Kiaa0204, Stk2
Domain
Architecture

No domain graphic available

Description STE20-like serine/threonine-protein kinase (EC 2.7.11.1) (STE20-like kinase) (STE20-related serine/threonine-protein kinase) (STE20-related kinase) (mSLK) (Serine/threonine-protein kinase 2) (STE20-related kinase SMAK) (Etk4).
ZFY1_MOUSE
 
NC score -0.000883 (rank : 25) θ value 6.88961 (rank : 21)
Query Neighborhood Hits 25 Target Neighborhood Hits 790 Shared Neighborhood Hits 3
SwissProt Accessions P10925 Gene names Zfy1, Zfy-1
Domain
Architecture
Description Zinc finger Y-chromosomal protein 1.