Please be patient as the page loads

Stop Image Loading/Displaying

Network neighborhood for query Sequence : PYGO1_MOUSE

For an explanation of this page, click here

PYGO1_MOUSE
SwissProt Accessions	Q9D0P5	Gene names	Pygo1
Domain Architecture
Description	Pygopus homolog 1.
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

PYGO1_HUMAN
θ value	0 (rank : 1)	NC score	0.971384 (rank : 2)
Query Neighborhood Hits	69	Target Neighborhood Hits	90	Shared Neighborhood Hits	38
SwissProt Accessions	Q9Y3Y4	Gene names	PYGO1
Domain Architecture
Description	Pygopus homolog 1.

PYGO1_MOUSE
θ value	0 (rank : 2)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	69	Target Neighborhood Hits	69	Shared Neighborhood Hits	69
SwissProt Accessions	Q9D0P5	Gene names	Pygo1
Domain Architecture
Description	Pygopus homolog 1.

PYGO2_HUMAN
θ value	1.7238e-59 (rank : 3)	NC score	0.793713 (rank : 3)
Query Neighborhood Hits	69	Target Neighborhood Hits	189	Shared Neighborhood Hits	20
SwissProt Accessions	Q9BRQ0, Q8WYZ4, Q96CY2	Gene names	PYGO2
Domain Architecture
Description	Pygopus homolog 2.

GAB2_HUMAN
θ value	0.0563607 (rank : 4)	NC score	0.080479 (rank : 9)
Query Neighborhood Hits	69	Target Neighborhood Hits	188	Shared Neighborhood Hits	9
SwissProt Accessions	Q9UQC2, O60317	Gene names	GAB2, KIAA0571
Domain Architecture
Description	GRB2-associated-binding protein 2 (GRB2-associated binder 2) (pp100).

NCOA1_HUMAN
θ value	0.0563607 (rank : 5)	NC score	0.043687 (rank : 29)
Query Neighborhood Hits	69	Target Neighborhood Hits	198	Shared Neighborhood Hits	8
SwissProt Accessions	Q15788, O00150, O43792, O43793, Q13071, Q13420, Q6GVI5, Q7KYV3	Gene names	NCOA1, SRC1
Domain Architecture	No domain graphic available
Description	Nuclear receptor coactivator 1 (EC 2.3.1.48) (NCoA-1) (Steroid receptor coactivator 1) (SRC-1) (RIP160) (Protein Hin-2) (NY-REN-52 antigen).

PRB3_HUMAN
θ value	0.0563607 (rank : 6)	NC score	0.078060 (rank : 10)
Query Neighborhood Hits	69	Target Neighborhood Hits	318	Shared Neighborhood Hits	10
SwissProt Accessions	Q04118, Q15188, Q7M4M9	Gene names	PRB3
Domain Architecture	No domain graphic available
Description	Basic salivary proline-rich protein 3 precursor (Parotid salivary glycoprotein G1) (Proline-rich protein G1).

MLL4_HUMAN
θ value	0.0736092 (rank : 7)	NC score	0.076630 (rank : 12)
Query Neighborhood Hits	69	Target Neighborhood Hits	722	Shared Neighborhood Hits	27
SwissProt Accessions	Q9UMN6, O15022, O95836, Q96GP2, Q96IP3, Q9UK25, Q9Y668, Q9Y669	Gene names	MLL4, HRX2, KIAA0304, MLL2, TRX2
Domain Architecture
Description	Myeloid/lymphoid or mixed-lineage leukemia protein 4 (Trithorax homolog 2).

NR1D1_HUMAN
θ value	0.0961366 (rank : 8)	NC score	0.025711 (rank : 47)
Query Neighborhood Hits	69	Target Neighborhood Hits	140	Shared Neighborhood Hits	7
SwissProt Accessions	P20393, Q15304	Gene names	NR1D1, EAR1, HREV, THRAL
Domain Architecture
Description	Orphan nuclear receptor NR1D1 (V-erbA-related protein EAR-1) (Rev- erbA-alpha).

ING3_HUMAN
θ value	0.21417 (rank : 9)	NC score	0.072307 (rank : 15)
Query Neighborhood Hits	69	Target Neighborhood Hits	178	Shared Neighborhood Hits	7
SwissProt Accessions	Q9NXR8, O60394, Q6GMT3, Q7Z762, Q969G0, Q96DT4, Q9HC99, Q9P081	Gene names	ING3
Domain Architecture	No domain graphic available
Description	Inhibitor of growth protein 3 (p47ING3 protein).

TAU_MOUSE
θ value	0.21417 (rank : 10)	NC score	0.043113 (rank : 30)
Query Neighborhood Hits	69	Target Neighborhood Hits	502	Shared Neighborhood Hits	11
SwissProt Accessions	P10637, P10638, Q60684, Q60685, Q60686, Q62286	Gene names	Mapt, Mtapt, Tau
Domain Architecture
Description	Microtubule-associated protein tau (Neurofibrillary tangle protein) (Paired helical filament-tau) (PHF-tau).

MAGC1_HUMAN
θ value	0.279714 (rank : 11)	NC score	0.039558 (rank : 34)
Query Neighborhood Hits	69	Target Neighborhood Hits	431	Shared Neighborhood Hits	16
SwissProt Accessions	O60732, O75451, Q8TCV4	Gene names	MAGEC1
Domain Architecture
Description	Melanoma-associated antigen C1 (MAGE-C1 antigen) (Cancer-testis antigen CT7).

PHF14_MOUSE
θ value	0.279714 (rank : 12)	NC score	0.074687 (rank : 13)
Query Neighborhood Hits	69	Target Neighborhood Hits	342	Shared Neighborhood Hits	17
SwissProt Accessions	Q9D4H9, Q810Z6, Q8C284, Q8CGF8, Q9D1Q8	Gene names	Phf14
Domain Architecture
Description	PHD finger protein 14.

BPTF_HUMAN
θ value	0.47712 (rank : 13)	NC score	0.058274 (rank : 18)
Query Neighborhood Hits	69	Target Neighborhood Hits	786	Shared Neighborhood Hits	25
SwissProt Accessions	Q12830, Q6NX67, Q7Z7D6, Q9UIG2	Gene names	FALZ, BPTF, FAC1
Domain Architecture
Description	Nucleosome remodeling factor subunit BPTF (Bromodomain and PHD finger- containing transcription factor) (Fetal Alzheimer antigen) (Fetal Alz- 50 clone 1 protein).

MYST4_MOUSE
θ value	0.47712 (rank : 14)	NC score	0.043800 (rank : 28)
Query Neighborhood Hits	69	Target Neighborhood Hits	416	Shared Neighborhood Hits	18
SwissProt Accessions	Q8BRB7, Q7TNW5, Q8BG35, Q8C441, Q9JKX5	Gene names	Myst4
Domain Architecture	No domain graphic available
Description	Histone acetyltransferase MYST4 (EC 2.3.1.48) (EC 2.3.1.-) (MYST protein 4) (MOZ, YBF2/SAS3, SAS2 and TIP60 protein 4) (Querkopf protein).

NCOA6_MOUSE
θ value	0.47712 (rank : 15)	NC score	0.073586 (rank : 14)
Query Neighborhood Hits	69	Target Neighborhood Hits	1076	Shared Neighborhood Hits	39
SwissProt Accessions	Q9JL19, Q9JLT9	Gene names	Ncoa6, Aib3, Prip, Rap250, Trbp
Domain Architecture	No domain graphic available
Description	Nuclear receptor coactivator 6 (Amplified in breast cancer protein 3) (Cancer-amplified transcriptional coactivator ASC-2) (Activating signal cointegrator 2) (ASC-2) (Peroxisome proliferator-activated receptor-interacting protein) (PPAR-interacting protein) (Nuclear receptor-activating protein, 250 kDa) (Nuclear receptor coactivator RAP250) (NRC) (Thyroid hormone receptor-binding protein).

PTN14_HUMAN
θ value	0.47712 (rank : 16)	NC score	0.020716 (rank : 50)
Query Neighborhood Hits	69	Target Neighborhood Hits	163	Shared Neighborhood Hits	5
SwissProt Accessions	Q15678	Gene names	PTPN14, PEZ
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 14 (EC 3.1.3.48) (Protein-tyrosine phosphatase pez).

CHD9_HUMAN
θ value	0.62314 (rank : 17)	NC score	0.017607 (rank : 55)
Query Neighborhood Hits	69	Target Neighborhood Hits	343	Shared Neighborhood Hits	7
SwissProt Accessions	Q3L8U1, O15025, Q1WF12, Q6DTK9, Q9H9V7	Gene names	CHD9, KIAA0308, KISH2, PRIC320
Domain Architecture	No domain graphic available
Description	Chromodomain-helicase-DNA-binding protein 9 (EC 3.6.1.-) (ATP- dependent helicase CHD9) (CHD-9) (Chromatin-related mesenchymal modulator) (CReMM) (Chromatin remodeling factor CHROM1) (Peroxisomal proliferator-activated receptor A-interacting complex 320 kDa protein) (PPAR-alpha-interacting complex protein 320 kDa) (Kismet homolog 2).

JAD1A_HUMAN
θ value	0.62314 (rank : 18)	NC score	0.048784 (rank : 27)
Query Neighborhood Hits	69	Target Neighborhood Hits	328	Shared Neighborhood Hits	19
SwissProt Accessions	P29375	Gene names	JARID1A, RBBP2, RBP2
Domain Architecture
Description	Jumonji/ARID domain-containing protein 1A (Retinoblastoma-binding protein 2) (RBBP-2).

PHF14_HUMAN
θ value	0.813845 (rank : 19)	NC score	0.070725 (rank : 16)
Query Neighborhood Hits	69	Target Neighborhood Hits	447	Shared Neighborhood Hits	17
SwissProt Accessions	O94880	Gene names	PHF14, KIAA0783
Domain Architecture	No domain graphic available
Description	PHD finger protein 14.

SF01_HUMAN
θ value	0.813845 (rank : 20)	NC score	0.056772 (rank : 21)
Query Neighborhood Hits	69	Target Neighborhood Hits	287	Shared Neighborhood Hits	11
SwissProt Accessions	Q15637, Q14818, Q14819, Q15913, Q8IY00, Q92744, Q92745, Q969H7, Q9BW01, Q9UEI0	Gene names	SF1, ZFM1, ZNF162
Domain Architecture
Description	Splicing factor 1 (Zinc finger protein 162) (Transcription factor ZFM1) (Zinc finger gene in MEN1 locus) (Mammalian branch point-binding protein mBBP) (BBP).

SF01_MOUSE
θ value	0.813845 (rank : 21)	NC score	0.058111 (rank : 19)
Query Neighborhood Hits	69	Target Neighborhood Hits	240	Shared Neighborhood Hits	9
SwissProt Accessions	Q64213, O08817, P70167, Q61454, Q921Z4	Gene names	Sf1, Zfm1, Zfp162
Domain Architecture
Description	Splicing factor 1 (Zinc finger protein 162) (Transcription factor ZFM1) (mZFM) (Zinc finger gene in MEN1 locus) (Mammalian branch point- binding protein mBBP) (BBP) (CW17).

SPT5H_HUMAN
θ value	0.813845 (rank : 22)	NC score	0.093277 (rank : 5)
Query Neighborhood Hits	69	Target Neighborhood Hits	436	Shared Neighborhood Hits	29
SwissProt Accessions	O00267, O43279, Q59G52, Q99639	Gene names	SUPT5H, SPT5, SPT5H
Domain Architecture	No domain graphic available
Description	Transcription elongation factor SPT5 (hSPT5) (DRB sensitivity-inducing factor large subunit) (DSIF large subunit) (DSIF p160) (Tat- cotransactivator 1 protein) (Tat-CT1 protein).

SPT5H_MOUSE
θ value	0.813845 (rank : 23)	NC score	0.093535 (rank : 4)
Query Neighborhood Hits	69	Target Neighborhood Hits	437	Shared Neighborhood Hits	28
SwissProt Accessions	O55201, Q3UJ77, Q3UJH1, Q3UKD7, Q3UM54, Q6PB73, Q6PDP0, Q6PFR4	Gene names	Supt5h
Domain Architecture	No domain graphic available
Description	Transcription elongation factor SPT5 (DRB sensitivity-inducing factor large subunit) (DSIF large subunit).

HELZ_HUMAN
θ value	1.06291 (rank : 24)	NC score	0.048838 (rank : 26)
Query Neighborhood Hits	69	Target Neighborhood Hits	198	Shared Neighborhood Hits	12
SwissProt Accessions	P42694	Gene names	HELZ, KIAA0054
Domain Architecture	No domain graphic available
Description	Probable helicase with zinc-finger domain (EC 3.6.1.-).

LATS1_MOUSE
θ value	1.06291 (rank : 25)	NC score	0.008281 (rank : 66)
Query Neighborhood Hits	69	Target Neighborhood Hits	1027	Shared Neighborhood Hits	12
SwissProt Accessions	Q8BYR2, Q9Z0W4	Gene names	Lats1, Warts
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase LATS1 (EC 2.7.11.1) (Large tumor suppressor homolog 1) (WARTS protein kinase).

TAB2_HUMAN
θ value	1.06291 (rank : 26)	NC score	0.040704 (rank : 32)
Query Neighborhood Hits	69	Target Neighborhood Hits	169	Shared Neighborhood Hits	4
SwissProt Accessions	Q9NYJ8, O94838, Q6I9W8, Q76N06, Q9UFP7	Gene names	MAP3K7IP2, KIAA0733, TAB2
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase 7-interacting protein 2 (TAK1-binding protein 2).

NCOA6_HUMAN
θ value	1.38821 (rank : 27)	NC score	0.077584 (rank : 11)
Query Neighborhood Hits	69	Target Neighborhood Hits	1202	Shared Neighborhood Hits	43
SwissProt Accessions	Q14686, Q9NTZ9, Q9UH74, Q9UK86	Gene names	NCOA6, AIB3, KIAA0181, RAP250, TRBP
Domain Architecture	No domain graphic available
Description	Nuclear receptor coactivator 6 (Amplified in breast cancer protein 3) (Cancer-amplified transcriptional coactivator ASC-2) (Activating signal cointegrator 2) (ASC-2) (Peroxisome proliferator-activated receptor-interacting protein) (PPAR-interacting protein) (PRIP) (Nuclear receptor-activating protein, 250 kDa) (Nuclear receptor coactivator RAP250) (NRC RAP250) (Thyroid hormone receptor-binding protein).

ORC2_HUMAN
θ value	1.38821 (rank : 28)	NC score	0.038034 (rank : 37)
Query Neighborhood Hits	69	Target Neighborhood Hits	33	Shared Neighborhood Hits	4
SwissProt Accessions	Q13416, Q13204	Gene names	ORC2L, ORC2
Domain Architecture
Description	Origin recognition complex subunit 2.

TAB3_HUMAN
θ value	1.81305 (rank : 29)	NC score	0.059078 (rank : 17)
Query Neighborhood Hits	69	Target Neighborhood Hits	168	Shared Neighborhood Hits	11
SwissProt Accessions	Q8N5C8, Q6VQR0	Gene names	MAP3K7IP3, TAB3
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase 7-interacting protein 3 (TAK1-binding protein 3) (NF-kappa-B-activating protein 1).

ZN645_HUMAN
θ value	1.81305 (rank : 30)	NC score	0.086031 (rank : 6)
Query Neighborhood Hits	69	Target Neighborhood Hits	265	Shared Neighborhood Hits	22
SwissProt Accessions	Q8N7E2, Q6DJY9	Gene names	ZNF645
Domain Architecture	No domain graphic available
Description	Zinc finger protein 645.

SN1L2_HUMAN
θ value	2.36792 (rank : 31)	NC score	0.004043 (rank : 69)
Query Neighborhood Hits	69	Target Neighborhood Hits	964	Shared Neighborhood Hits	8
SwissProt Accessions	Q9H0K1, O94878, Q6AZE2, Q76N03, Q8NCV7, Q96CZ8	Gene names	SNF1LK2, KIAA0781, QIK
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase SNF1-like kinase 2 (EC 2.7.11.1) (Qin- induced kinase).

WASIP_MOUSE
θ value	2.36792 (rank : 32)	NC score	0.083857 (rank : 8)
Query Neighborhood Hits	69	Target Neighborhood Hits	392	Shared Neighborhood Hits	16
SwissProt Accessions	Q8K1I7, Q3U0U8	Gene names	Waspip, Wip
Domain Architecture	No domain graphic available
Description	Wiskott-Aldrich syndrome protein-interacting protein (WASP-interacting protein).

WIRE_HUMAN
θ value	2.36792 (rank : 33)	NC score	0.034815 (rank : 41)
Query Neighborhood Hits	69	Target Neighborhood Hits	329	Shared Neighborhood Hits	11
SwissProt Accessions	Q8TF74, Q658J8, Q71RE1, Q8TE44	Gene names	WIRE, WICH
Domain Architecture	No domain graphic available
Description	WIP-related protein (WASP-interacting protein-related protein) (WIP- and CR16-homologous protein).

ING3_MOUSE
θ value	3.0926 (rank : 34)	NC score	0.042502 (rank : 31)
Query Neighborhood Hits	69	Target Neighborhood Hits	177	Shared Neighborhood Hits	7
SwissProt Accessions	Q8VEK6, Q99JS6, Q9ERB2	Gene names	Ing3
Domain Architecture	No domain graphic available
Description	Inhibitor of growth protein 3 (p47ING3 protein).

MYST4_HUMAN
θ value	3.0926 (rank : 35)	NC score	0.038170 (rank : 36)
Query Neighborhood Hits	69	Target Neighborhood Hits	671	Shared Neighborhood Hits	17
SwissProt Accessions	Q8WYB5, O15087, Q86Y05, Q8WU81, Q9UKW2, Q9UKW3, Q9UKX0	Gene names	MYST4, KIAA0383, MORF, MOZ2
Domain Architecture	No domain graphic available
Description	Histone acetyltransferase MYST4 (EC 2.3.1.48) (EC 2.3.1.-) (MYST protein 4) (MOZ, YBF2/SAS3, SAS2 and TIP60 protein 4) (Histone acetyltransferase MOZ2) (Monocytic leukemia zinc finger protein- related factor) (Histone acetyltransferase MORF).

PTN23_HUMAN
θ value	3.0926 (rank : 36)	NC score	0.028962 (rank : 44)
Query Neighborhood Hits	69	Target Neighborhood Hits	646	Shared Neighborhood Hits	16
SwissProt Accessions	Q9H3S7, Q7KZF8, Q8N6Z5, Q9BSR5, Q9P257, Q9UG03, Q9UMZ4	Gene names	PTPN23, KIAA1471
Domain Architecture	No domain graphic available
Description	Tyrosine-protein phosphatase non-receptor type 23 (EC 3.1.3.48) (His- domain-containing protein tyrosine phosphatase) (HD-PTP) (Protein tyrosine phosphatase TD14) (PTP-TD14).

SIP1_MOUSE
θ value	3.0926 (rank : 37)	NC score	0.005354 (rank : 67)
Query Neighborhood Hits	69	Target Neighborhood Hits	870	Shared Neighborhood Hits	4
SwissProt Accessions	Q9R0G7	Gene names	Zfhx1b, Sip1, Zfx1b
Domain Architecture
Description	Zinc finger homeobox protein 1b (Smad-interacting protein 1).

WASL_HUMAN
θ value	3.0926 (rank : 38)	NC score	0.039804 (rank : 33)
Query Neighborhood Hits	69	Target Neighborhood Hits	312	Shared Neighborhood Hits	11
SwissProt Accessions	O00401, Q7Z746	Gene names	WASL
Domain Architecture
Description	Neural Wiskott-Aldrich syndrome protein (N-WASP).

ZMYM3_HUMAN
θ value	3.0926 (rank : 39)	NC score	0.023784 (rank : 48)
Query Neighborhood Hits	69	Target Neighborhood Hits	223	Shared Neighborhood Hits	8
SwissProt Accessions	Q14202, O15089	Gene names	ZMYM3, DXS6673E, KIAA0385, ZNF261
Domain Architecture	No domain graphic available
Description	Zinc finger MYM-type protein 3 (Zinc finger protein 261).

DAAM2_HUMAN
θ value	4.03905 (rank : 40)	NC score	0.016694 (rank : 58)
Query Neighborhood Hits	69	Target Neighborhood Hits	350	Shared Neighborhood Hits	7
SwissProt Accessions	Q86T65, Q5T4U0, Q9NQI5, Q9Y4G0	Gene names	DAAM2, KIAA0381
Domain Architecture
Description	Disheveled-associated activator of morphogenesis 2.

DIAP1_HUMAN
θ value	4.03905 (rank : 41)	NC score	0.018336 (rank : 54)
Query Neighborhood Hits	69	Target Neighborhood Hits	784	Shared Neighborhood Hits	12
SwissProt Accessions	O60610, Q9UC76	Gene names	DIAPH1, DIAP1
Domain Architecture
Description	Protein diaphanous homolog 1 (Diaphanous-related formin-1) (DRF1).

F113A_MOUSE
θ value	4.03905 (rank : 42)	NC score	0.025998 (rank : 46)
Query Neighborhood Hits	69	Target Neighborhood Hits	11	Shared Neighborhood Hits	2
SwissProt Accessions	Q6P1Z5	Gene names	Fam113a
Domain Architecture	No domain graphic available
Description	Protein FAM113A.

NUFP1_MOUSE
θ value	4.03905 (rank : 43)	NC score	0.037097 (rank : 40)
Query Neighborhood Hits	69	Target Neighborhood Hits	113	Shared Neighborhood Hits	3
SwissProt Accessions	Q9QXX8, Q9CV69	Gene names	Nufip1
Domain Architecture	No domain graphic available
Description	Nuclear fragile X mental retardation-interacting protein 1 (Nuclear FMRP-interacting protein 1).

SFPQ_MOUSE
θ value	4.03905 (rank : 44)	NC score	0.037820 (rank : 38)
Query Neighborhood Hits	69	Target Neighborhood Hits	958	Shared Neighborhood Hits	21
SwissProt Accessions	Q8VIJ6, Q9ERW2	Gene names	Sfpq
Domain Architecture	No domain graphic available
Description	Splicing factor, proline- and glutamine-rich (Polypyrimidine tract- binding protein-associated-splicing factor) (PTB-associated-splicing factor) (PSF) (DNA-binding p52/p100 complex, 100 kDa subunit).

SIP1_HUMAN
θ value	4.03905 (rank : 45)	NC score	0.005241 (rank : 68)
Query Neighborhood Hits	69	Target Neighborhood Hits	832	Shared Neighborhood Hits	6
SwissProt Accessions	O60315, Q9UED1	Gene names	ZFHX1B, KIAA0569, SIP1, ZFX1B
Domain Architecture
Description	Zinc finger homeobox protein 1b (Smad-interacting protein 1) (SMADIP1).

CCNL1_MOUSE
θ value	5.27518 (rank : 46)	NC score	0.013764 (rank : 60)
Query Neighborhood Hits	69	Target Neighborhood Hits	71	Shared Neighborhood Hits	2
SwissProt Accessions	Q52KE7, Q8BQ75, Q8R5H9, Q922K0, Q9CSZ3, Q9WV44	Gene names	Ccnl1, Ania6a, Ccn1
Domain Architecture	No domain graphic available
Description	Cyclin-L1 (Cyclin-L) (Cyclin Ania-6a).

MLL2_HUMAN
θ value	5.27518 (rank : 47)	NC score	0.057470 (rank : 20)
Query Neighborhood Hits	69	Target Neighborhood Hits	1788	Shared Neighborhood Hits	38
SwissProt Accessions	O14686, O14687	Gene names	MLL2, ALR
Domain Architecture
Description	Myeloid/lymphoid or mixed-lineage leukemia protein 2 (ALL1-related protein).

MLL3_HUMAN
θ value	5.27518 (rank : 48)	NC score	0.055857 (rank : 23)
Query Neighborhood Hits	69	Target Neighborhood Hits	1644	Shared Neighborhood Hits	44
SwissProt Accessions	Q8NEZ4, Q8NC02, Q8NDF6, Q9H9P4, Q9NR13, Q9P222, Q9UDR7	Gene names	MLL3, HALR, KIAA1506
Domain Architecture
Description	Myeloid/lymphoid or mixed-lineage leukemia protein 3 homolog (EC 2.1.1.43) (Histone-lysine N-methyltransferase, H3 lysine-4 specific MLL3) (Homologous to ALR protein).

PARC_HUMAN
θ value	5.27518 (rank : 49)	NC score	0.013007 (rank : 61)
Query Neighborhood Hits	69	Target Neighborhood Hits	148	Shared Neighborhood Hits	3
SwissProt Accessions	Q8IWT3, O75188, Q68CP2, Q68D92, Q8N3W9, Q9BU56	Gene names	PARC, H7AP1, KIAA0708
Domain Architecture
Description	p53-associated parkin-like cytoplasmic protein (UbcH7-associated protein 1).

ARI1A_HUMAN
θ value	6.88961 (rank : 50)	NC score	0.056102 (rank : 22)
Query Neighborhood Hits	69	Target Neighborhood Hits	787	Shared Neighborhood Hits	32
SwissProt Accessions	O14497, Q53FK9, Q5T0W1, Q5T0W2, Q5T0W3, Q8NFD6, Q96T89, Q9BY33, Q9HBJ5, Q9UPZ1	Gene names	ARID1A, C1orf4, OSA1, SMARCF1
Domain Architecture
Description	AT-rich interactive domain-containing protein 1A (ARID domain- containing protein 1A) (SWI/SNF-related, matrix-associated, actin- dependent regulator of chromatin subfamily F member 1) (SWI-SNF complex protein p270) (B120) (SWI-like protein) (Osa homolog 1) (hOSA1) (hELD) (BRG1-associated factor 250) (BAF250) (BRG1-associated factor 250a) (BAF250A).

BSN_HUMAN
θ value	6.88961 (rank : 51)	NC score	0.020482 (rank : 51)
Query Neighborhood Hits	69	Target Neighborhood Hits	1537	Shared Neighborhood Hits	23
SwissProt Accessions	Q9UPA5, O43161, Q7LGH3	Gene names	BSN, KIAA0434, ZNF231
Domain Architecture	No domain graphic available
Description	Protein bassoon (Zinc finger protein 231).

HNRL1_MOUSE
θ value	6.88961 (rank : 52)	NC score	0.016507 (rank : 59)
Query Neighborhood Hits	69	Target Neighborhood Hits	200	Shared Neighborhood Hits	10
SwissProt Accessions	Q8VDM6, Q3U201, Q3UPB0, Q6AZA7, Q8BY45, Q8K365	Gene names	Hnrpul1
Domain Architecture	No domain graphic available
Description	Heterogeneous nuclear ribonucleoprotein U-like protein 1.

NOP56_MOUSE
θ value	6.88961 (rank : 53)	NC score	0.016716 (rank : 57)
Query Neighborhood Hits	69	Target Neighborhood Hits	129	Shared Neighborhood Hits	6
SwissProt Accessions	Q9D6Z1, Q3UD45, Q8BVL1, Q8VDT2, Q99LT8, Q9CT15	Gene names	Nol5a, Nop56
Domain Architecture
Description	Nucleolar protein Nop56 (Nucleolar protein 5A).

PCD15_MOUSE
θ value	6.88961 (rank : 54)	NC score	0.003858 (rank : 70)
Query Neighborhood Hits	69	Target Neighborhood Hits	262	Shared Neighborhood Hits	3
SwissProt Accessions	Q99PJ1	Gene names	Pcdh15
Domain Architecture
Description	Protocadherin-15 precursor.

PRPC_HUMAN
θ value	6.88961 (rank : 55)	NC score	0.085249 (rank : 7)
Query Neighborhood Hits	69	Target Neighborhood Hits	165	Shared Neighborhood Hits	8
SwissProt Accessions	P02810, Q4VBP2, Q53XA2, Q6P2F6	Gene names	PRH1
Domain Architecture	No domain graphic available
Description	Salivary acidic proline-rich phosphoprotein 1/2 precursor (PRP-1/PRP- 2) (Parotid proline-rich protein 1/2) (Pr1/Pr2) (Protein C) (Parotid acidic protein) (Pa) (Parotid isoelectric focusing variant protein) (PIF-S) (Parotid double-band protein) (Db-s) [Contains: Salivary acidic proline-rich phosphoprotein 1/2; Salivary acidic proline-rich phosphoprotein 3/4 (PRP-3/PRP-4) (Protein A) (PIF-F) (Db-F); Peptide P-C].

SHAN1_HUMAN
θ value	6.88961 (rank : 56)	NC score	0.012596 (rank : 62)
Query Neighborhood Hits	69	Target Neighborhood Hits	1041	Shared Neighborhood Hits	17
SwissProt Accessions	Q9Y566, Q9NYW9	Gene names	SHANK1
Domain Architecture
Description	SH3 and multiple ankyrin repeat domains protein 1 (Shank1) (Somatostatin receptor-interacting protein) (SSTR-interacting protein) (SSTRIP).

SMN_HUMAN
θ value	6.88961 (rank : 57)	NC score	0.039481 (rank : 35)
Query Neighborhood Hits	69	Target Neighborhood Hits	39	Shared Neighborhood Hits	3
SwissProt Accessions	Q16637, Q13119, Q96J51	Gene names	SMN1, SMN, SMNT
Domain Architecture
Description	Survival motor neuron protein (Component of gems 1) (Gemin-1).

CASC5_HUMAN
θ value	8.99809 (rank : 58)	NC score	0.012481 (rank : 63)
Query Neighborhood Hits	69	Target Neighborhood Hits	376	Shared Neighborhood Hits	5
SwissProt Accessions	Q8NG31, Q8NHE1, Q8WXA6, Q9HCK2, Q9NR92	Gene names	CASC5, KIAA1570
Domain Architecture	No domain graphic available
Description	Protein CASC5 (Cancer susceptibility candidate gene 5 protein) (ALL1- fused gene from chromosome 15q14) (AF15q14) (D40/AF15q14 protein).

ENAM_HUMAN
θ value	8.99809 (rank : 59)	NC score	0.023780 (rank : 49)
Query Neighborhood Hits	69	Target Neighborhood Hits	227	Shared Neighborhood Hits	17
SwissProt Accessions	Q9NRM1, Q9H3D1	Gene names	ENAM
Domain Architecture
Description	Enamelin precursor.

H6ST2_HUMAN
θ value	8.99809 (rank : 60)	NC score	0.010745 (rank : 65)
Query Neighborhood Hits	69	Target Neighborhood Hits	17	Shared Neighborhood Hits	2
SwissProt Accessions	Q96MM7, Q4VC07, Q6PIC4, Q86SM9, Q8N3T4, Q8NBN4, Q96SJ4	Gene names	HS6ST2
Domain Architecture	No domain graphic available
Description	Heparan-sulfate 6-O-sulfotransferase 2 (EC 2.8.2.-) (HS6ST-2).

MAK_MOUSE
θ value	8.99809 (rank : 61)	NC score	0.000842 (rank : 71)
Query Neighborhood Hits	69	Target Neighborhood Hits	873	Shared Neighborhood Hits	6
SwissProt Accessions	Q04859	Gene names	Mak, Rck
Domain Architecture
Description	Serine/threonine-protein kinase MAK (EC 2.7.11.22) (Male germ cell- associated kinase) (Protein kinase RCK).

NSD1_HUMAN
θ value	8.99809 (rank : 62)	NC score	0.037312 (rank : 39)
Query Neighborhood Hits	69	Target Neighborhood Hits	427	Shared Neighborhood Hits	22
SwissProt Accessions	Q96L73, Q96PD8, Q96RN7	Gene names	NSD1, ARA267
Domain Architecture
Description	Histone-lysine N-methyltransferase, H3 lysine-36 and H4 lysine-20 specific (EC 2.1.1.43) (H3-K36-HMTase) (H4-K20-HMTase) (Nuclear receptor-binding SET domain-containing protein 1) (NR-binding SET domain-containing protein) (Androgen receptor-associated coregulator 267).

PHF20_HUMAN
θ value	8.99809 (rank : 63)	NC score	0.031351 (rank : 42)
Query Neighborhood Hits	69	Target Neighborhood Hits	394	Shared Neighborhood Hits	17
SwissProt Accessions	Q9BVI0, Q5JWY9, Q9BWV4, Q9BXA3, Q9BZW3, Q9H421, Q9H4J6, Q9NZ22	Gene names	PHF20, C20orf104, GLEA2, HCA58, NZF, TZP
Domain Architecture
Description	PHD finger protein 20 (Hepatocellular carcinoma-associated antigen 58) (Glioma-expressed antigen 2) (Transcription factor TZP) (Novel zinc finger protein).

PHF20_MOUSE
θ value	8.99809 (rank : 64)	NC score	0.030484 (rank : 43)
Query Neighborhood Hits	69	Target Neighborhood Hits	513	Shared Neighborhood Hits	17
SwissProt Accessions	Q8BLG0, Q8BMA2, Q8BYR4, Q921N1	Gene names	Phf20, Hca58
Domain Architecture
Description	PHD finger protein 20 (Hepatocellular carcinoma-associated antigen 58 homolog).

RERE_MOUSE
θ value	8.99809 (rank : 65)	NC score	0.028359 (rank : 45)
Query Neighborhood Hits	69	Target Neighborhood Hits	785	Shared Neighborhood Hits	20
SwissProt Accessions	Q80TZ9	Gene names	Rere, Atr2, Kiaa0458
Domain Architecture	No domain graphic available
Description	Arginine-glutamic acid dipeptide repeats protein (Atrophin-2).

RXRB_MOUSE
θ value	8.99809 (rank : 66)	NC score	0.011095 (rank : 64)
Query Neighborhood Hits	69	Target Neighborhood Hits	230	Shared Neighborhood Hits	12
SwissProt Accessions	P28704, P33243	Gene names	Rxrb, Nr2b2
Domain Architecture
Description	Retinoic acid receptor RXR-beta (Retinoid X receptor beta) (MHC class I regulatory element-binding protein H-2RIIBP).

SRRM1_HUMAN
θ value	8.99809 (rank : 67)	NC score	0.016787 (rank : 56)
Query Neighborhood Hits	69	Target Neighborhood Hits	690	Shared Neighborhood Hits	17
SwissProt Accessions	Q8IYB3, O60585, Q5VVN4	Gene names	SRRM1, SRM160
Domain Architecture	No domain graphic available
Description	Serine/arginine repetitive matrix protein 1 (Ser/Arg-related nuclear matrix protein) (SR-related nuclear matrix protein of 160 kDa) (SRm160).

SSBP3_HUMAN
θ value	8.99809 (rank : 68)	NC score	0.018882 (rank : 52)
Query Neighborhood Hits	69	Target Neighborhood Hits	132	Shared Neighborhood Hits	8
SwissProt Accessions	Q9BWW4, Q9BTM0, Q9BWW3	Gene names	SSBP3, SSDP, SSDP1
Domain Architecture
Description	Single-stranded DNA-binding protein 3 (Sequence-specific single- stranded-DNA-binding protein).

SSBP3_MOUSE
θ value	8.99809 (rank : 69)	NC score	0.018882 (rank : 53)
Query Neighborhood Hits	69	Target Neighborhood Hits	132	Shared Neighborhood Hits	8
SwissProt Accessions	Q9D032, Q99LC6, Q9EQP3	Gene names	Ssbp3, Last, Ssdp1
Domain Architecture
Description	Single-stranded DNA-binding protein 3 (Sequence-specific single- stranded-DNA-binding protein) (Lck-associated signal transducer).

MLL3_MOUSE
θ value	θ > 10 (rank : 70)	NC score	0.050362 (rank : 25)
Query Neighborhood Hits	69	Target Neighborhood Hits	1399	Shared Neighborhood Hits	43
SwissProt Accessions	Q8BRH4, Q5YLV9, Q8BK12, Q8C6M3, Q923H5, Q923H6	Gene names	Mll3
Domain Architecture
Description	Myeloid/lymphoid or mixed-lineage leukemia protein 3 homolog (EC 2.1.1.43) (Histone-lysine N-methyltransferase, H3 lysine-4 specific MLL3).

ZIM10_HUMAN
θ value	θ > 10 (rank : 71)	NC score	0.052002 (rank : 24)
Query Neighborhood Hits	69	Target Neighborhood Hits	577	Shared Neighborhood Hits	36
SwissProt Accessions	Q9ULJ6, Q7Z7E6	Gene names	RAI17, KIAA1224, ZIMP10
Domain Architecture	No domain graphic available
Description	Retinoic acid-induced protein 17 (PIAS-like protein Zimp10).

Hits sorted by NC score

PYGO1_MOUSE
NC score	0.999962 (rank : 1)	θ value	0 (rank : 2)
Query Neighborhood Hits	69	Target Neighborhood Hits	69	Shared Neighborhood Hits	69
SwissProt Accessions	Q9D0P5	Gene names	Pygo1
Domain Architecture
Description	Pygopus homolog 1.

PYGO1_HUMAN
NC score	0.971384 (rank : 2)	θ value	0 (rank : 1)
Query Neighborhood Hits	69	Target Neighborhood Hits	90	Shared Neighborhood Hits	38
SwissProt Accessions	Q9Y3Y4	Gene names	PYGO1
Domain Architecture
Description	Pygopus homolog 1.

PYGO2_HUMAN
NC score	0.793713 (rank : 3)	θ value	1.7238e-59 (rank : 3)
Query Neighborhood Hits	69	Target Neighborhood Hits	189	Shared Neighborhood Hits	20
SwissProt Accessions	Q9BRQ0, Q8WYZ4, Q96CY2	Gene names	PYGO2
Domain Architecture
Description	Pygopus homolog 2.

SPT5H_MOUSE
NC score	0.093535 (rank : 4)	θ value	0.813845 (rank : 23)
Query Neighborhood Hits	69	Target Neighborhood Hits	437	Shared Neighborhood Hits	28
SwissProt Accessions	O55201, Q3UJ77, Q3UJH1, Q3UKD7, Q3UM54, Q6PB73, Q6PDP0, Q6PFR4	Gene names	Supt5h
Domain Architecture	No domain graphic available
Description	Transcription elongation factor SPT5 (DRB sensitivity-inducing factor large subunit) (DSIF large subunit).

SPT5H_HUMAN
NC score	0.093277 (rank : 5)	θ value	0.813845 (rank : 22)
Query Neighborhood Hits	69	Target Neighborhood Hits	436	Shared Neighborhood Hits	29
SwissProt Accessions	O00267, O43279, Q59G52, Q99639	Gene names	SUPT5H, SPT5, SPT5H
Domain Architecture	No domain graphic available
Description	Transcription elongation factor SPT5 (hSPT5) (DRB sensitivity-inducing factor large subunit) (DSIF large subunit) (DSIF p160) (Tat- cotransactivator 1 protein) (Tat-CT1 protein).

ZN645_HUMAN
NC score	0.086031 (rank : 6)	θ value	1.81305 (rank : 30)
Query Neighborhood Hits	69	Target Neighborhood Hits	265	Shared Neighborhood Hits	22
SwissProt Accessions	Q8N7E2, Q6DJY9	Gene names	ZNF645
Domain Architecture	No domain graphic available
Description	Zinc finger protein 645.

PRPC_HUMAN
NC score	0.085249 (rank : 7)	θ value	6.88961 (rank : 55)
Query Neighborhood Hits	69	Target Neighborhood Hits	165	Shared Neighborhood Hits	8
SwissProt Accessions	P02810, Q4VBP2, Q53XA2, Q6P2F6	Gene names	PRH1
Domain Architecture	No domain graphic available
Description	Salivary acidic proline-rich phosphoprotein 1/2 precursor (PRP-1/PRP- 2) (Parotid proline-rich protein 1/2) (Pr1/Pr2) (Protein C) (Parotid acidic protein) (Pa) (Parotid isoelectric focusing variant protein) (PIF-S) (Parotid double-band protein) (Db-s) [Contains: Salivary acidic proline-rich phosphoprotein 1/2; Salivary acidic proline-rich phosphoprotein 3/4 (PRP-3/PRP-4) (Protein A) (PIF-F) (Db-F); Peptide P-C].

WASIP_MOUSE
NC score	0.083857 (rank : 8)	θ value	2.36792 (rank : 32)
Query Neighborhood Hits	69	Target Neighborhood Hits	392	Shared Neighborhood Hits	16
SwissProt Accessions	Q8K1I7, Q3U0U8	Gene names	Waspip, Wip
Domain Architecture	No domain graphic available
Description	Wiskott-Aldrich syndrome protein-interacting protein (WASP-interacting protein).

GAB2_HUMAN
NC score	0.080479 (rank : 9)	θ value	0.0563607 (rank : 4)
Query Neighborhood Hits	69	Target Neighborhood Hits	188	Shared Neighborhood Hits	9
SwissProt Accessions	Q9UQC2, O60317	Gene names	GAB2, KIAA0571
Domain Architecture
Description	GRB2-associated-binding protein 2 (GRB2-associated binder 2) (pp100).

PRB3_HUMAN
NC score	0.078060 (rank : 10)	θ value	0.0563607 (rank : 6)
Query Neighborhood Hits	69	Target Neighborhood Hits	318	Shared Neighborhood Hits	10
SwissProt Accessions	Q04118, Q15188, Q7M4M9	Gene names	PRB3
Domain Architecture	No domain graphic available
Description	Basic salivary proline-rich protein 3 precursor (Parotid salivary glycoprotein G1) (Proline-rich protein G1).

NCOA6_HUMAN
NC score	0.077584 (rank : 11)	θ value	1.38821 (rank : 27)
Query Neighborhood Hits	69	Target Neighborhood Hits	1202	Shared Neighborhood Hits	43
SwissProt Accessions	Q14686, Q9NTZ9, Q9UH74, Q9UK86	Gene names	NCOA6, AIB3, KIAA0181, RAP250, TRBP
Domain Architecture	No domain graphic available
Description	Nuclear receptor coactivator 6 (Amplified in breast cancer protein 3) (Cancer-amplified transcriptional coactivator ASC-2) (Activating signal cointegrator 2) (ASC-2) (Peroxisome proliferator-activated receptor-interacting protein) (PPAR-interacting protein) (PRIP) (Nuclear receptor-activating protein, 250 kDa) (Nuclear receptor coactivator RAP250) (NRC RAP250) (Thyroid hormone receptor-binding protein).

MLL4_HUMAN
NC score	0.076630 (rank : 12)	θ value	0.0736092 (rank : 7)
Query Neighborhood Hits	69	Target Neighborhood Hits	722	Shared Neighborhood Hits	27
SwissProt Accessions	Q9UMN6, O15022, O95836, Q96GP2, Q96IP3, Q9UK25, Q9Y668, Q9Y669	Gene names	MLL4, HRX2, KIAA0304, MLL2, TRX2
Domain Architecture
Description	Myeloid/lymphoid or mixed-lineage leukemia protein 4 (Trithorax homolog 2).

PHF14_MOUSE
NC score	0.074687 (rank : 13)	θ value	0.279714 (rank : 12)
Query Neighborhood Hits	69	Target Neighborhood Hits	342	Shared Neighborhood Hits	17
SwissProt Accessions	Q9D4H9, Q810Z6, Q8C284, Q8CGF8, Q9D1Q8	Gene names	Phf14
Domain Architecture
Description	PHD finger protein 14.

NCOA6_MOUSE
NC score	0.073586 (rank : 14)	θ value	0.47712 (rank : 15)
Query Neighborhood Hits	69	Target Neighborhood Hits	1076	Shared Neighborhood Hits	39
SwissProt Accessions	Q9JL19, Q9JLT9	Gene names	Ncoa6, Aib3, Prip, Rap250, Trbp
Domain Architecture	No domain graphic available
Description	Nuclear receptor coactivator 6 (Amplified in breast cancer protein 3) (Cancer-amplified transcriptional coactivator ASC-2) (Activating signal cointegrator 2) (ASC-2) (Peroxisome proliferator-activated receptor-interacting protein) (PPAR-interacting protein) (Nuclear receptor-activating protein, 250 kDa) (Nuclear receptor coactivator RAP250) (NRC) (Thyroid hormone receptor-binding protein).

ING3_HUMAN
NC score	0.072307 (rank : 15)	θ value	0.21417 (rank : 9)
Query Neighborhood Hits	69	Target Neighborhood Hits	178	Shared Neighborhood Hits	7
SwissProt Accessions	Q9NXR8, O60394, Q6GMT3, Q7Z762, Q969G0, Q96DT4, Q9HC99, Q9P081	Gene names	ING3
Domain Architecture	No domain graphic available
Description	Inhibitor of growth protein 3 (p47ING3 protein).

PHF14_HUMAN
NC score	0.070725 (rank : 16)	θ value	0.813845 (rank : 19)
Query Neighborhood Hits	69	Target Neighborhood Hits	447	Shared Neighborhood Hits	17
SwissProt Accessions	O94880	Gene names	PHF14, KIAA0783
Domain Architecture	No domain graphic available
Description	PHD finger protein 14.

TAB3_HUMAN
NC score	0.059078 (rank : 17)	θ value	1.81305 (rank : 29)
Query Neighborhood Hits	69	Target Neighborhood Hits	168	Shared Neighborhood Hits	11
SwissProt Accessions	Q8N5C8, Q6VQR0	Gene names	MAP3K7IP3, TAB3
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase 7-interacting protein 3 (TAK1-binding protein 3) (NF-kappa-B-activating protein 1).

BPTF_HUMAN
NC score	0.058274 (rank : 18)	θ value	0.47712 (rank : 13)
Query Neighborhood Hits	69	Target Neighborhood Hits	786	Shared Neighborhood Hits	25
SwissProt Accessions	Q12830, Q6NX67, Q7Z7D6, Q9UIG2	Gene names	FALZ, BPTF, FAC1
Domain Architecture
Description	Nucleosome remodeling factor subunit BPTF (Bromodomain and PHD finger- containing transcription factor) (Fetal Alzheimer antigen) (Fetal Alz- 50 clone 1 protein).

SF01_MOUSE
NC score	0.058111 (rank : 19)	θ value	0.813845 (rank : 21)
Query Neighborhood Hits	69	Target Neighborhood Hits	240	Shared Neighborhood Hits	9
SwissProt Accessions	Q64213, O08817, P70167, Q61454, Q921Z4	Gene names	Sf1, Zfm1, Zfp162
Domain Architecture
Description	Splicing factor 1 (Zinc finger protein 162) (Transcription factor ZFM1) (mZFM) (Zinc finger gene in MEN1 locus) (Mammalian branch point- binding protein mBBP) (BBP) (CW17).

MLL2_HUMAN
NC score	0.057470 (rank : 20)	θ value	5.27518 (rank : 47)
Query Neighborhood Hits	69	Target Neighborhood Hits	1788	Shared Neighborhood Hits	38
SwissProt Accessions	O14686, O14687	Gene names	MLL2, ALR
Domain Architecture
Description	Myeloid/lymphoid or mixed-lineage leukemia protein 2 (ALL1-related protein).

SF01_HUMAN
NC score	0.056772 (rank : 21)	θ value	0.813845 (rank : 20)
Query Neighborhood Hits	69	Target Neighborhood Hits	287	Shared Neighborhood Hits	11
SwissProt Accessions	Q15637, Q14818, Q14819, Q15913, Q8IY00, Q92744, Q92745, Q969H7, Q9BW01, Q9UEI0	Gene names	SF1, ZFM1, ZNF162
Domain Architecture
Description	Splicing factor 1 (Zinc finger protein 162) (Transcription factor ZFM1) (Zinc finger gene in MEN1 locus) (Mammalian branch point-binding protein mBBP) (BBP).

ARI1A_HUMAN
NC score	0.056102 (rank : 22)	θ value	6.88961 (rank : 50)
Query Neighborhood Hits	69	Target Neighborhood Hits	787	Shared Neighborhood Hits	32
SwissProt Accessions	O14497, Q53FK9, Q5T0W1, Q5T0W2, Q5T0W3, Q8NFD6, Q96T89, Q9BY33, Q9HBJ5, Q9UPZ1	Gene names	ARID1A, C1orf4, OSA1, SMARCF1
Domain Architecture
Description	AT-rich interactive domain-containing protein 1A (ARID domain- containing protein 1A) (SWI/SNF-related, matrix-associated, actin- dependent regulator of chromatin subfamily F member 1) (SWI-SNF complex protein p270) (B120) (SWI-like protein) (Osa homolog 1) (hOSA1) (hELD) (BRG1-associated factor 250) (BAF250) (BRG1-associated factor 250a) (BAF250A).

MLL3_HUMAN
NC score	0.055857 (rank : 23)	θ value	5.27518 (rank : 48)
Query Neighborhood Hits	69	Target Neighborhood Hits	1644	Shared Neighborhood Hits	44
SwissProt Accessions	Q8NEZ4, Q8NC02, Q8NDF6, Q9H9P4, Q9NR13, Q9P222, Q9UDR7	Gene names	MLL3, HALR, KIAA1506
Domain Architecture
Description	Myeloid/lymphoid or mixed-lineage leukemia protein 3 homolog (EC 2.1.1.43) (Histone-lysine N-methyltransferase, H3 lysine-4 specific MLL3) (Homologous to ALR protein).

ZIM10_HUMAN
NC score	0.052002 (rank : 24)	θ value	θ > 10 (rank : 71)
Query Neighborhood Hits	69	Target Neighborhood Hits	577	Shared Neighborhood Hits	36
SwissProt Accessions	Q9ULJ6, Q7Z7E6	Gene names	RAI17, KIAA1224, ZIMP10
Domain Architecture	No domain graphic available
Description	Retinoic acid-induced protein 17 (PIAS-like protein Zimp10).

MLL3_MOUSE
NC score	0.050362 (rank : 25)	θ value	θ > 10 (rank : 70)
Query Neighborhood Hits	69	Target Neighborhood Hits	1399	Shared Neighborhood Hits	43
SwissProt Accessions	Q8BRH4, Q5YLV9, Q8BK12, Q8C6M3, Q923H5, Q923H6	Gene names	Mll3
Domain Architecture
Description	Myeloid/lymphoid or mixed-lineage leukemia protein 3 homolog (EC 2.1.1.43) (Histone-lysine N-methyltransferase, H3 lysine-4 specific MLL3).

HELZ_HUMAN
NC score	0.048838 (rank : 26)	θ value	1.06291 (rank : 24)
Query Neighborhood Hits	69	Target Neighborhood Hits	198	Shared Neighborhood Hits	12
SwissProt Accessions	P42694	Gene names	HELZ, KIAA0054
Domain Architecture	No domain graphic available
Description	Probable helicase with zinc-finger domain (EC 3.6.1.-).

JAD1A_HUMAN
NC score	0.048784 (rank : 27)	θ value	0.62314 (rank : 18)
Query Neighborhood Hits	69	Target Neighborhood Hits	328	Shared Neighborhood Hits	19
SwissProt Accessions	P29375	Gene names	JARID1A, RBBP2, RBP2
Domain Architecture
Description	Jumonji/ARID domain-containing protein 1A (Retinoblastoma-binding protein 2) (RBBP-2).

MYST4_MOUSE
NC score	0.043800 (rank : 28)	θ value	0.47712 (rank : 14)
Query Neighborhood Hits	69	Target Neighborhood Hits	416	Shared Neighborhood Hits	18
SwissProt Accessions	Q8BRB7, Q7TNW5, Q8BG35, Q8C441, Q9JKX5	Gene names	Myst4
Domain Architecture	No domain graphic available
Description	Histone acetyltransferase MYST4 (EC 2.3.1.48) (EC 2.3.1.-) (MYST protein 4) (MOZ, YBF2/SAS3, SAS2 and TIP60 protein 4) (Querkopf protein).

NCOA1_HUMAN
NC score	0.043687 (rank : 29)	θ value	0.0563607 (rank : 5)
Query Neighborhood Hits	69	Target Neighborhood Hits	198	Shared Neighborhood Hits	8
SwissProt Accessions	Q15788, O00150, O43792, O43793, Q13071, Q13420, Q6GVI5, Q7KYV3	Gene names	NCOA1, SRC1
Domain Architecture	No domain graphic available
Description	Nuclear receptor coactivator 1 (EC 2.3.1.48) (NCoA-1) (Steroid receptor coactivator 1) (SRC-1) (RIP160) (Protein Hin-2) (NY-REN-52 antigen).

TAU_MOUSE
NC score	0.043113 (rank : 30)	θ value	0.21417 (rank : 10)
Query Neighborhood Hits	69	Target Neighborhood Hits	502	Shared Neighborhood Hits	11
SwissProt Accessions	P10637, P10638, Q60684, Q60685, Q60686, Q62286	Gene names	Mapt, Mtapt, Tau
Domain Architecture
Description	Microtubule-associated protein tau (Neurofibrillary tangle protein) (Paired helical filament-tau) (PHF-tau).

ING3_MOUSE
NC score	0.042502 (rank : 31)	θ value	3.0926 (rank : 34)
Query Neighborhood Hits	69	Target Neighborhood Hits	177	Shared Neighborhood Hits	7
SwissProt Accessions	Q8VEK6, Q99JS6, Q9ERB2	Gene names	Ing3
Domain Architecture	No domain graphic available
Description	Inhibitor of growth protein 3 (p47ING3 protein).

TAB2_HUMAN
NC score	0.040704 (rank : 32)	θ value	1.06291 (rank : 26)
Query Neighborhood Hits	69	Target Neighborhood Hits	169	Shared Neighborhood Hits	4
SwissProt Accessions	Q9NYJ8, O94838, Q6I9W8, Q76N06, Q9UFP7	Gene names	MAP3K7IP2, KIAA0733, TAB2
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase 7-interacting protein 2 (TAK1-binding protein 2).

WASL_HUMAN
NC score	0.039804 (rank : 33)	θ value	3.0926 (rank : 38)
Query Neighborhood Hits	69	Target Neighborhood Hits	312	Shared Neighborhood Hits	11
SwissProt Accessions	O00401, Q7Z746	Gene names	WASL
Domain Architecture
Description	Neural Wiskott-Aldrich syndrome protein (N-WASP).

MAGC1_HUMAN
NC score	0.039558 (rank : 34)	θ value	0.279714 (rank : 11)
Query Neighborhood Hits	69	Target Neighborhood Hits	431	Shared Neighborhood Hits	16
SwissProt Accessions	O60732, O75451, Q8TCV4	Gene names	MAGEC1
Domain Architecture
Description	Melanoma-associated antigen C1 (MAGE-C1 antigen) (Cancer-testis antigen CT7).

SMN_HUMAN
NC score	0.039481 (rank : 35)	θ value	6.88961 (rank : 57)
Query Neighborhood Hits	69	Target Neighborhood Hits	39	Shared Neighborhood Hits	3
SwissProt Accessions	Q16637, Q13119, Q96J51	Gene names	SMN1, SMN, SMNT
Domain Architecture
Description	Survival motor neuron protein (Component of gems 1) (Gemin-1).

MYST4_HUMAN
NC score	0.038170 (rank : 36)	θ value	3.0926 (rank : 35)
Query Neighborhood Hits	69	Target Neighborhood Hits	671	Shared Neighborhood Hits	17
SwissProt Accessions	Q8WYB5, O15087, Q86Y05, Q8WU81, Q9UKW2, Q9UKW3, Q9UKX0	Gene names	MYST4, KIAA0383, MORF, MOZ2
Domain Architecture	No domain graphic available
Description	Histone acetyltransferase MYST4 (EC 2.3.1.48) (EC 2.3.1.-) (MYST protein 4) (MOZ, YBF2/SAS3, SAS2 and TIP60 protein 4) (Histone acetyltransferase MOZ2) (Monocytic leukemia zinc finger protein- related factor) (Histone acetyltransferase MORF).

ORC2_HUMAN
NC score	0.038034 (rank : 37)	θ value	1.38821 (rank : 28)
Query Neighborhood Hits	69	Target Neighborhood Hits	33	Shared Neighborhood Hits	4
SwissProt Accessions	Q13416, Q13204	Gene names	ORC2L, ORC2
Domain Architecture
Description	Origin recognition complex subunit 2.

SFPQ_MOUSE
NC score	0.037820 (rank : 38)	θ value	4.03905 (rank : 44)
Query Neighborhood Hits	69	Target Neighborhood Hits	958	Shared Neighborhood Hits	21
SwissProt Accessions	Q8VIJ6, Q9ERW2	Gene names	Sfpq
Domain Architecture	No domain graphic available
Description	Splicing factor, proline- and glutamine-rich (Polypyrimidine tract- binding protein-associated-splicing factor) (PTB-associated-splicing factor) (PSF) (DNA-binding p52/p100 complex, 100 kDa subunit).

NSD1_HUMAN
NC score	0.037312 (rank : 39)	θ value	8.99809 (rank : 62)
Query Neighborhood Hits	69	Target Neighborhood Hits	427	Shared Neighborhood Hits	22
SwissProt Accessions	Q96L73, Q96PD8, Q96RN7	Gene names	NSD1, ARA267
Domain Architecture
Description	Histone-lysine N-methyltransferase, H3 lysine-36 and H4 lysine-20 specific (EC 2.1.1.43) (H3-K36-HMTase) (H4-K20-HMTase) (Nuclear receptor-binding SET domain-containing protein 1) (NR-binding SET domain-containing protein) (Androgen receptor-associated coregulator 267).

NUFP1_MOUSE
NC score	0.037097 (rank : 40)	θ value	4.03905 (rank : 43)
Query Neighborhood Hits	69	Target Neighborhood Hits	113	Shared Neighborhood Hits	3
SwissProt Accessions	Q9QXX8, Q9CV69	Gene names	Nufip1
Domain Architecture	No domain graphic available
Description	Nuclear fragile X mental retardation-interacting protein 1 (Nuclear FMRP-interacting protein 1).

WIRE_HUMAN
NC score	0.034815 (rank : 41)	θ value	2.36792 (rank : 33)
Query Neighborhood Hits	69	Target Neighborhood Hits	329	Shared Neighborhood Hits	11
SwissProt Accessions	Q8TF74, Q658J8, Q71RE1, Q8TE44	Gene names	WIRE, WICH
Domain Architecture	No domain graphic available
Description	WIP-related protein (WASP-interacting protein-related protein) (WIP- and CR16-homologous protein).

PHF20_HUMAN
NC score	0.031351 (rank : 42)	θ value	8.99809 (rank : 63)
Query Neighborhood Hits	69	Target Neighborhood Hits	394	Shared Neighborhood Hits	17
SwissProt Accessions	Q9BVI0, Q5JWY9, Q9BWV4, Q9BXA3, Q9BZW3, Q9H421, Q9H4J6, Q9NZ22	Gene names	PHF20, C20orf104, GLEA2, HCA58, NZF, TZP
Domain Architecture
Description	PHD finger protein 20 (Hepatocellular carcinoma-associated antigen 58) (Glioma-expressed antigen 2) (Transcription factor TZP) (Novel zinc finger protein).

PHF20_MOUSE
NC score	0.030484 (rank : 43)	θ value	8.99809 (rank : 64)
Query Neighborhood Hits	69	Target Neighborhood Hits	513	Shared Neighborhood Hits	17
SwissProt Accessions	Q8BLG0, Q8BMA2, Q8BYR4, Q921N1	Gene names	Phf20, Hca58
Domain Architecture
Description	PHD finger protein 20 (Hepatocellular carcinoma-associated antigen 58 homolog).

PTN23_HUMAN
NC score	0.028962 (rank : 44)	θ value	3.0926 (rank : 36)
Query Neighborhood Hits	69	Target Neighborhood Hits	646	Shared Neighborhood Hits	16
SwissProt Accessions	Q9H3S7, Q7KZF8, Q8N6Z5, Q9BSR5, Q9P257, Q9UG03, Q9UMZ4	Gene names	PTPN23, KIAA1471
Domain Architecture	No domain graphic available
Description	Tyrosine-protein phosphatase non-receptor type 23 (EC 3.1.3.48) (His- domain-containing protein tyrosine phosphatase) (HD-PTP) (Protein tyrosine phosphatase TD14) (PTP-TD14).

RERE_MOUSE
NC score	0.028359 (rank : 45)	θ value	8.99809 (rank : 65)
Query Neighborhood Hits	69	Target Neighborhood Hits	785	Shared Neighborhood Hits	20
SwissProt Accessions	Q80TZ9	Gene names	Rere, Atr2, Kiaa0458
Domain Architecture	No domain graphic available
Description	Arginine-glutamic acid dipeptide repeats protein (Atrophin-2).

F113A_MOUSE
NC score	0.025998 (rank : 46)	θ value	4.03905 (rank : 42)
Query Neighborhood Hits	69	Target Neighborhood Hits	11	Shared Neighborhood Hits	2
SwissProt Accessions	Q6P1Z5	Gene names	Fam113a
Domain Architecture	No domain graphic available
Description	Protein FAM113A.

NR1D1_HUMAN
NC score	0.025711 (rank : 47)	θ value	0.0961366 (rank : 8)
Query Neighborhood Hits	69	Target Neighborhood Hits	140	Shared Neighborhood Hits	7
SwissProt Accessions	P20393, Q15304	Gene names	NR1D1, EAR1, HREV, THRAL
Domain Architecture
Description	Orphan nuclear receptor NR1D1 (V-erbA-related protein EAR-1) (Rev- erbA-alpha).

ZMYM3_HUMAN
NC score	0.023784 (rank : 48)	θ value	3.0926 (rank : 39)
Query Neighborhood Hits	69	Target Neighborhood Hits	223	Shared Neighborhood Hits	8
SwissProt Accessions	Q14202, O15089	Gene names	ZMYM3, DXS6673E, KIAA0385, ZNF261
Domain Architecture	No domain graphic available
Description	Zinc finger MYM-type protein 3 (Zinc finger protein 261).

ENAM_HUMAN
NC score	0.023780 (rank : 49)	θ value	8.99809 (rank : 59)
Query Neighborhood Hits	69	Target Neighborhood Hits	227	Shared Neighborhood Hits	17
SwissProt Accessions	Q9NRM1, Q9H3D1	Gene names	ENAM
Domain Architecture
Description	Enamelin precursor.

PTN14_HUMAN
NC score	0.020716 (rank : 50)	θ value	0.47712 (rank : 16)
Query Neighborhood Hits	69	Target Neighborhood Hits	163	Shared Neighborhood Hits	5
SwissProt Accessions	Q15678	Gene names	PTPN14, PEZ
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 14 (EC 3.1.3.48) (Protein-tyrosine phosphatase pez).

BSN_HUMAN
NC score	0.020482 (rank : 51)	θ value	6.88961 (rank : 51)
Query Neighborhood Hits	69	Target Neighborhood Hits	1537	Shared Neighborhood Hits	23
SwissProt Accessions	Q9UPA5, O43161, Q7LGH3	Gene names	BSN, KIAA0434, ZNF231
Domain Architecture	No domain graphic available
Description	Protein bassoon (Zinc finger protein 231).

SSBP3_HUMAN
NC score	0.018882 (rank : 52)	θ value	8.99809 (rank : 68)
Query Neighborhood Hits	69	Target Neighborhood Hits	132	Shared Neighborhood Hits	8
SwissProt Accessions	Q9BWW4, Q9BTM0, Q9BWW3	Gene names	SSBP3, SSDP, SSDP1
Domain Architecture
Description	Single-stranded DNA-binding protein 3 (Sequence-specific single- stranded-DNA-binding protein).

SSBP3_MOUSE
NC score	0.018882 (rank : 53)	θ value	8.99809 (rank : 69)
Query Neighborhood Hits	69	Target Neighborhood Hits	132	Shared Neighborhood Hits	8
SwissProt Accessions	Q9D032, Q99LC6, Q9EQP3	Gene names	Ssbp3, Last, Ssdp1
Domain Architecture
Description	Single-stranded DNA-binding protein 3 (Sequence-specific single- stranded-DNA-binding protein) (Lck-associated signal transducer).

DIAP1_HUMAN
NC score	0.018336 (rank : 54)	θ value	4.03905 (rank : 41)
Query Neighborhood Hits	69	Target Neighborhood Hits	784	Shared Neighborhood Hits	12
SwissProt Accessions	O60610, Q9UC76	Gene names	DIAPH1, DIAP1
Domain Architecture
Description	Protein diaphanous homolog 1 (Diaphanous-related formin-1) (DRF1).

CHD9_HUMAN
NC score	0.017607 (rank : 55)	θ value	0.62314 (rank : 17)
Query Neighborhood Hits	69	Target Neighborhood Hits	343	Shared Neighborhood Hits	7
SwissProt Accessions	Q3L8U1, O15025, Q1WF12, Q6DTK9, Q9H9V7	Gene names	CHD9, KIAA0308, KISH2, PRIC320
Domain Architecture	No domain graphic available
Description	Chromodomain-helicase-DNA-binding protein 9 (EC 3.6.1.-) (ATP- dependent helicase CHD9) (CHD-9) (Chromatin-related mesenchymal modulator) (CReMM) (Chromatin remodeling factor CHROM1) (Peroxisomal proliferator-activated receptor A-interacting complex 320 kDa protein) (PPAR-alpha-interacting complex protein 320 kDa) (Kismet homolog 2).

SRRM1_HUMAN
NC score	0.016787 (rank : 56)	θ value	8.99809 (rank : 67)
Query Neighborhood Hits	69	Target Neighborhood Hits	690	Shared Neighborhood Hits	17
SwissProt Accessions	Q8IYB3, O60585, Q5VVN4	Gene names	SRRM1, SRM160
Domain Architecture	No domain graphic available
Description	Serine/arginine repetitive matrix protein 1 (Ser/Arg-related nuclear matrix protein) (SR-related nuclear matrix protein of 160 kDa) (SRm160).

NOP56_MOUSE
NC score	0.016716 (rank : 57)	θ value	6.88961 (rank : 53)
Query Neighborhood Hits	69	Target Neighborhood Hits	129	Shared Neighborhood Hits	6
SwissProt Accessions	Q9D6Z1, Q3UD45, Q8BVL1, Q8VDT2, Q99LT8, Q9CT15	Gene names	Nol5a, Nop56
Domain Architecture
Description	Nucleolar protein Nop56 (Nucleolar protein 5A).

DAAM2_HUMAN
NC score	0.016694 (rank : 58)	θ value	4.03905 (rank : 40)
Query Neighborhood Hits	69	Target Neighborhood Hits	350	Shared Neighborhood Hits	7
SwissProt Accessions	Q86T65, Q5T4U0, Q9NQI5, Q9Y4G0	Gene names	DAAM2, KIAA0381
Domain Architecture
Description	Disheveled-associated activator of morphogenesis 2.

HNRL1_MOUSE
NC score	0.016507 (rank : 59)	θ value	6.88961 (rank : 52)
Query Neighborhood Hits	69	Target Neighborhood Hits	200	Shared Neighborhood Hits	10
SwissProt Accessions	Q8VDM6, Q3U201, Q3UPB0, Q6AZA7, Q8BY45, Q8K365	Gene names	Hnrpul1
Domain Architecture	No domain graphic available
Description	Heterogeneous nuclear ribonucleoprotein U-like protein 1.

CCNL1_MOUSE
NC score	0.013764 (rank : 60)	θ value	5.27518 (rank : 46)
Query Neighborhood Hits	69	Target Neighborhood Hits	71	Shared Neighborhood Hits	2
SwissProt Accessions	Q52KE7, Q8BQ75, Q8R5H9, Q922K0, Q9CSZ3, Q9WV44	Gene names	Ccnl1, Ania6a, Ccn1
Domain Architecture	No domain graphic available
Description	Cyclin-L1 (Cyclin-L) (Cyclin Ania-6a).

PARC_HUMAN
NC score	0.013007 (rank : 61)	θ value	5.27518 (rank : 49)
Query Neighborhood Hits	69	Target Neighborhood Hits	148	Shared Neighborhood Hits	3
SwissProt Accessions	Q8IWT3, O75188, Q68CP2, Q68D92, Q8N3W9, Q9BU56	Gene names	PARC, H7AP1, KIAA0708
Domain Architecture
Description	p53-associated parkin-like cytoplasmic protein (UbcH7-associated protein 1).

SHAN1_HUMAN
NC score	0.012596 (rank : 62)	θ value	6.88961 (rank : 56)
Query Neighborhood Hits	69	Target Neighborhood Hits	1041	Shared Neighborhood Hits	17
SwissProt Accessions	Q9Y566, Q9NYW9	Gene names	SHANK1
Domain Architecture
Description	SH3 and multiple ankyrin repeat domains protein 1 (Shank1) (Somatostatin receptor-interacting protein) (SSTR-interacting protein) (SSTRIP).

CASC5_HUMAN
NC score	0.012481 (rank : 63)	θ value	8.99809 (rank : 58)
Query Neighborhood Hits	69	Target Neighborhood Hits	376	Shared Neighborhood Hits	5
SwissProt Accessions	Q8NG31, Q8NHE1, Q8WXA6, Q9HCK2, Q9NR92	Gene names	CASC5, KIAA1570
Domain Architecture	No domain graphic available
Description	Protein CASC5 (Cancer susceptibility candidate gene 5 protein) (ALL1- fused gene from chromosome 15q14) (AF15q14) (D40/AF15q14 protein).

RXRB_MOUSE
NC score	0.011095 (rank : 64)	θ value	8.99809 (rank : 66)
Query Neighborhood Hits	69	Target Neighborhood Hits	230	Shared Neighborhood Hits	12
SwissProt Accessions	P28704, P33243	Gene names	Rxrb, Nr2b2
Domain Architecture
Description	Retinoic acid receptor RXR-beta (Retinoid X receptor beta) (MHC class I regulatory element-binding protein H-2RIIBP).

H6ST2_HUMAN
NC score	0.010745 (rank : 65)	θ value	8.99809 (rank : 60)
Query Neighborhood Hits	69	Target Neighborhood Hits	17	Shared Neighborhood Hits	2
SwissProt Accessions	Q96MM7, Q4VC07, Q6PIC4, Q86SM9, Q8N3T4, Q8NBN4, Q96SJ4	Gene names	HS6ST2
Domain Architecture	No domain graphic available
Description	Heparan-sulfate 6-O-sulfotransferase 2 (EC 2.8.2.-) (HS6ST-2).

LATS1_MOUSE
NC score	0.008281 (rank : 66)	θ value	1.06291 (rank : 25)
Query Neighborhood Hits	69	Target Neighborhood Hits	1027	Shared Neighborhood Hits	12
SwissProt Accessions	Q8BYR2, Q9Z0W4	Gene names	Lats1, Warts
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase LATS1 (EC 2.7.11.1) (Large tumor suppressor homolog 1) (WARTS protein kinase).

SIP1_MOUSE
NC score	0.005354 (rank : 67)	θ value	3.0926 (rank : 37)
Query Neighborhood Hits	69	Target Neighborhood Hits	870	Shared Neighborhood Hits	4
SwissProt Accessions	Q9R0G7	Gene names	Zfhx1b, Sip1, Zfx1b
Domain Architecture
Description	Zinc finger homeobox protein 1b (Smad-interacting protein 1).

SIP1_HUMAN
NC score	0.005241 (rank : 68)	θ value	4.03905 (rank : 45)
Query Neighborhood Hits	69	Target Neighborhood Hits	832	Shared Neighborhood Hits	6
SwissProt Accessions	O60315, Q9UED1	Gene names	ZFHX1B, KIAA0569, SIP1, ZFX1B
Domain Architecture
Description	Zinc finger homeobox protein 1b (Smad-interacting protein 1) (SMADIP1).

SN1L2_HUMAN
NC score	0.004043 (rank : 69)	θ value	2.36792 (rank : 31)
Query Neighborhood Hits	69	Target Neighborhood Hits	964	Shared Neighborhood Hits	8
SwissProt Accessions	Q9H0K1, O94878, Q6AZE2, Q76N03, Q8NCV7, Q96CZ8	Gene names	SNF1LK2, KIAA0781, QIK
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase SNF1-like kinase 2 (EC 2.7.11.1) (Qin- induced kinase).

PCD15_MOUSE
NC score	0.003858 (rank : 70)	θ value	6.88961 (rank : 54)
Query Neighborhood Hits	69	Target Neighborhood Hits	262	Shared Neighborhood Hits	3
SwissProt Accessions	Q99PJ1	Gene names	Pcdh15
Domain Architecture
Description	Protocadherin-15 precursor.

MAK_MOUSE
NC score	0.000842 (rank : 71)	θ value	8.99809 (rank : 61)
Query Neighborhood Hits	69	Target Neighborhood Hits	873	Shared Neighborhood Hits	6
SwissProt Accessions	Q04859	Gene names	Mak, Rck
Domain Architecture
Description	Serine/threonine-protein kinase MAK (EC 2.7.11.22) (Male germ cell- associated kinase) (Protein kinase RCK).