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Network neighborhood for query Sequence : PSMD9_MOUSE

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PSMD9_MOUSE
SwissProt Accessions	Q9CR00, Q3TG66	Gene names	Psmd9
Domain Architecture
Description	26S proteasome non-ATPase regulatory subunit 9 (26S proteasome regulatory subunit p27).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

PSMD9_MOUSE
θ value	2.45477e-106 (rank : 1)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	30	Target Neighborhood Hits	30	Shared Neighborhood Hits	30
SwissProt Accessions	Q9CR00, Q3TG66	Gene names	Psmd9
Domain Architecture
Description	26S proteasome non-ATPase regulatory subunit 9 (26S proteasome regulatory subunit p27).

PSMD9_HUMAN
θ value	1.75921e-104 (rank : 2)	NC score	0.986541 (rank : 2)
Query Neighborhood Hits	30	Target Neighborhood Hits	36	Shared Neighborhood Hits	23
SwissProt Accessions	O00233, Q9BQ42	Gene names	PSMD9
Domain Architecture
Description	26S proteasome non-ATPase regulatory subunit 9 (26S proteasome regulatory subunit p27).

GR65_HUMAN
θ value	0.00390308 (rank : 3)	NC score	0.227977 (rank : 3)
Query Neighborhood Hits	30	Target Neighborhood Hits	148	Shared Neighborhood Hits	6
SwissProt Accessions	Q9BQQ3, Q8N272, Q96H42	Gene names	GORASP1, GRASP65
Domain Architecture	No domain graphic available
Description	Golgi reassembly-stacking protein 1 (Golgi reassembly-stacking protein of 65 kDa) (GRASP65) (Golgi peripheral membrane protein p65) (Golgi phosphoprotein 5) (GOLPH5).

GR65_MOUSE
θ value	0.0113563 (rank : 4)	NC score	0.223808 (rank : 4)
Query Neighborhood Hits	30	Target Neighborhood Hits	54	Shared Neighborhood Hits	6
SwissProt Accessions	Q91X51, Q9D3L9	Gene names	Gorasp1
Domain Architecture	No domain graphic available
Description	Golgi reassembly-stacking protein 1 (Golgi reassembly-stacking protein of 65 kDa) (GRASP65) (Golgi peripheral membrane protein p65).

NHRF2_MOUSE
θ value	0.0113563 (rank : 5)	NC score	0.157179 (rank : 7)
Query Neighborhood Hits	30	Target Neighborhood Hits	194	Shared Neighborhood Hits	22
SwissProt Accessions	Q9JHL1, Q3TDR3, Q8BGL9, Q8BW05, Q9DCR6	Gene names	Slc9a3r2, Nherf2
Domain Architecture
Description	Na(+)/H(+) exchange regulatory cofactor NHE-RF2 (NHERF-2) (Tyrosine kinase activator protein 1) (TKA-1) (SRY-interacting protein 1) (SIP- 1) (Solute carrier family 9 isoform A3 regulatory factor 2) (NHE3 kinase A regulatory protein E3KARP) (Sodium-hydrogen exchanger regulatory factor 2) (Octs2).

NHRF2_HUMAN
θ value	0.125558 (rank : 6)	NC score	0.142604 (rank : 8)
Query Neighborhood Hits	30	Target Neighborhood Hits	197	Shared Neighborhood Hits	22
SwissProt Accessions	Q15599, O00272, O00556	Gene names	SLC9A3R2, NHERF2
Domain Architecture
Description	Na(+)/H(+) exchange regulatory cofactor NHE-RF2 (NHERF-2) (Tyrosine kinase activator protein 1) (TKA-1) (SRY-interacting protein 1) (SIP- 1) (Solute carrier family 9 isoform A3 regulatory factor 2) (NHE3 kinase A regulatory protein E3KARP) (Sodium-hydrogen exchanger regulatory factor 2).

INADL_MOUSE
θ value	0.279714 (rank : 7)	NC score	0.093257 (rank : 14)
Query Neighborhood Hits	30	Target Neighborhood Hits	290	Shared Neighborhood Hits	21
SwissProt Accessions	Q63ZW7, O70471, Q5PRG3, Q6P6J1, Q80YR8, Q8BPB9	Gene names	Inadl, Cipp, Patj
Domain Architecture	No domain graphic available
Description	InaD-like protein (Inadl protein) (Pals1-associated tight junction protein) (Protein associated to tight junctions) (Channel-interacting PDZ domain-containing protein).

GORS2_HUMAN
θ value	0.365318 (rank : 8)	NC score	0.184822 (rank : 5)
Query Neighborhood Hits	30	Target Neighborhood Hits	82	Shared Neighborhood Hits	7
SwissProt Accessions	Q9H8Y8, Q96I74, Q96K84, Q9H946, Q9UFW4	Gene names	GORASP2
Domain Architecture	No domain graphic available
Description	Golgi reassembly-stacking protein 2 (GRS2) (Golgi reassembly-stacking protein of 55 kDa) (GRASP55) (p59) (Golgi phosphoprotein 6) (GOLPH6).

GORS2_MOUSE
θ value	0.365318 (rank : 9)	NC score	0.182196 (rank : 6)
Query Neighborhood Hits	30	Target Neighborhood Hits	89	Shared Neighborhood Hits	6
SwissProt Accessions	Q99JX3, Q3U9D2, Q8CCD0, Q91W68	Gene names	Gorasp2
Domain Architecture	No domain graphic available
Description	Golgi reassembly-stacking protein 2 (GRS2) (Golgi reassembly-stacking protein of 55 kDa) (GRASP55).

PDZD1_HUMAN
θ value	0.62314 (rank : 10)	NC score	0.110355 (rank : 10)
Query Neighborhood Hits	30	Target Neighborhood Hits	190	Shared Neighborhood Hits	23
SwissProt Accessions	Q5T2W1, O60450, Q5T5P6, Q9BQ41	Gene names	PDZK1, CAP70, NHERF3, PDZD1
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 1 (CFTR-associated protein of 70 kDa) (Na/Pi cotransporter C-terminal-associated protein) (NaPi-Cap1) (Na(+)/H(+) exchanger regulatory factor 3) (Sodium-hydrogen exchanger regulatory factor 3).

WHRN_MOUSE
θ value	0.813845 (rank : 11)	NC score	0.090382 (rank : 15)
Query Neighborhood Hits	30	Target Neighborhood Hits	412	Shared Neighborhood Hits	23
SwissProt Accessions	Q80VW5, Q80TC2, Q80VW4	Gene names	Whrn, Kiaa1526
Domain Architecture	No domain graphic available
Description	Whirlin.

INADL_HUMAN
θ value	1.06291 (rank : 12)	NC score	0.093568 (rank : 13)
Query Neighborhood Hits	30	Target Neighborhood Hits	260	Shared Neighborhood Hits	21
SwissProt Accessions	Q8NI35, O15249, O43742, O60833, Q5VUA5, Q5VUA6, Q5VUA7, Q5VUA8, Q5VUA9, Q5VUB0, Q8WU78, Q9H3N9	Gene names	INADL, PATJ
Domain Architecture	No domain graphic available
Description	InaD-like protein (Inadl protein) (hINADL) (Pals1-associated tight junction protein) (Protein associated to tight junctions).

MPDZ_HUMAN
θ value	1.06291 (rank : 13)	NC score	0.077908 (rank : 18)
Query Neighborhood Hits	30	Target Neighborhood Hits	261	Shared Neighborhood Hits	23
SwissProt Accessions	O75970, O43798, Q5CZ80, Q5JTX3, Q5JTX6, Q5JTX7, Q5JUC3, Q5JUC4, Q5VZ62, Q8N790	Gene names	MPDZ, MUPP1
Domain Architecture	No domain graphic available
Description	Multiple PDZ domain protein (Multi PDZ domain protein 1) (Multi-PDZ- domain protein 1).

PDLI1_HUMAN
θ value	1.06291 (rank : 14)	NC score	0.056339 (rank : 30)
Query Neighborhood Hits	30	Target Neighborhood Hits	242	Shared Neighborhood Hits	18
SwissProt Accessions	O00151, Q5VZH5, Q9BPZ9	Gene names	PDLIM1, CLIM1, CLP36
Domain Architecture
Description	PDZ and LIM domain protein 1 (Elfin) (LIM domain protein CLP-36) (C- terminal LIM domain protein 1).

RPGF2_HUMAN
θ value	1.06291 (rank : 15)	NC score	0.071566 (rank : 21)
Query Neighborhood Hits	30	Target Neighborhood Hits	242	Shared Neighborhood Hits	20
SwissProt Accessions	Q9Y4G8	Gene names	RAPGEF2, KIAA0313, NRAPGEP, PDZGEF1
Domain Architecture	No domain graphic available
Description	Rap guanine nucleotide exchange factor 2 (Neural RAP guanine nucleotide exchange protein) (nRap GEP) (PDZ domain-containing guanine nucleotide exchange factor 1) (PDZ-GEF1) (RA-GEF).

HTRA1_HUMAN
θ value	1.38821 (rank : 16)	NC score	0.053935 (rank : 31)
Query Neighborhood Hits	30	Target Neighborhood Hits	155	Shared Neighborhood Hits	14
SwissProt Accessions	Q92743, Q9UNS5	Gene names	HTRA1, HTRA, PRSS11
Domain Architecture
Description	Serine protease HTRA1 precursor (EC 3.4.21.-) (L56).

NHERF_HUMAN
θ value	1.38821 (rank : 17)	NC score	0.129608 (rank : 9)
Query Neighborhood Hits	30	Target Neighborhood Hits	190	Shared Neighborhood Hits	22
SwissProt Accessions	O14745, O43552, Q86WQ5	Gene names	SLC9A3R1, NHERF
Domain Architecture
Description	Ezrin-radixin-moesin-binding phosphoprotein 50 (EBP50) (Na(+)/H(+) exchange regulatory cofactor NHE-RF) (NHERF-1) (Regulatory cofactor of Na(+)/H(+) exchanger) (Sodium-hydrogen exchanger regulatory factor 1) (Solute carrier family 9 isoform 3 regulatory factor 1).

CUL5_HUMAN
θ value	3.0926 (rank : 18)	NC score	0.020802 (rank : 37)
Query Neighborhood Hits	30	Target Neighborhood Hits	46	Shared Neighborhood Hits	2
SwissProt Accessions	Q93034, O14766, Q9BZC6	Gene names	CUL5, VACM1
Domain Architecture
Description	Cullin-5 (CUL-5) (Vasopressin-activated calcium-mobilizing receptor) (VACM-1).

MPDZ_MOUSE
θ value	4.03905 (rank : 19)	NC score	0.075170 (rank : 20)
Query Neighborhood Hits	30	Target Neighborhood Hits	298	Shared Neighborhood Hits	22
SwissProt Accessions	Q8VBX6, O08783, Q6P7U4, Q80ZY8, Q8BKJ1, Q8C0H8, Q8VBV5, Q8VBY0, Q9Z1K3	Gene names	Mpdz, Mupp1
Domain Architecture	No domain graphic available
Description	Multiple PDZ domain protein (Multi PDZ domain protein 1) (Multi-PDZ domain protein 1).

RPGF6_HUMAN
θ value	4.03905 (rank : 20)	NC score	0.068513 (rank : 25)
Query Neighborhood Hits	30	Target Neighborhood Hits	266	Shared Neighborhood Hits	21
SwissProt Accessions	Q8TEU7, Q8NI21, Q8TEU6, Q96PC1	Gene names	RAPGEF6, PDZGEF2
Domain Architecture
Description	Rap guanine nucleotide exchange factor 6 (PDZ domain-containing guanine nucleotide exchange factor 2) (PDZ-GEF2) (RA-GEF-2).

PSCBP_HUMAN
θ value	5.27518 (rank : 21)	NC score	0.064624 (rank : 27)
Query Neighborhood Hits	30	Target Neighborhood Hits	123	Shared Neighborhood Hits	20
SwissProt Accessions	O60759, Q15630, Q8NE32	Gene names	PSCDBP, CYTIP
Domain Architecture	No domain graphic available
Description	Pleckstrin homology Sec7 and coiled-coil domains-binding protein (Cytohesin-binding protein HE) (CYBR) (Cytohesin binder and regulator) (Cytohesin-interacting protein).

SRGP1_HUMAN
θ value	5.27518 (rank : 22)	NC score	0.010985 (rank : 39)
Query Neighborhood Hits	30	Target Neighborhood Hits	390	Shared Neighborhood Hits	2
SwissProt Accessions	Q7Z6B7, Q9H8A3, Q9P2P2	Gene names	SRGAP1, ARHGAP13, KIAA1304
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 1 (srGAP1) (Rho-GTPase- activating protein 13).

HTRA1_MOUSE
θ value	6.88961 (rank : 23)	NC score	0.042199 (rank : 35)
Query Neighborhood Hits	30	Target Neighborhood Hits	140	Shared Neighborhood Hits	15
SwissProt Accessions	Q9R118	Gene names	Htra1, Htra, Prss11
Domain Architecture
Description	Serine protease HTRA1 precursor (EC 3.4.21.-).

LMO7_HUMAN
θ value	6.88961 (rank : 24)	NC score	0.036763 (rank : 36)
Query Neighborhood Hits	30	Target Neighborhood Hits	507	Shared Neighborhood Hits	15
SwissProt Accessions	Q8WWI1, O15462, O95346, Q9UKC1, Q9UQM5, Q9Y6A7	Gene names	LMO7, FBX20, FBXO20, KIAA0858
Domain Architecture
Description	LIM domain only protein 7 (LOMP) (F-box only protein 20).

PDZD1_MOUSE
θ value	6.88961 (rank : 25)	NC score	0.106718 (rank : 11)
Query Neighborhood Hits	30	Target Neighborhood Hits	191	Shared Neighborhood Hits	22
SwissProt Accessions	Q9JIL4, Q8CDP5, Q8R4G2, Q9CQ72	Gene names	Pdzk1, Cap70, Nherf3
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 1 (CFTR-associated protein of 70 kDa) (Na/Pi cotransporter C-terminal-associated protein) (NaPi-Cap1) (Na(+)/H(+) exchanger regulatory factor 3) (Sodium-hydrogen exchanger regulatory factor 3).

PSCBP_MOUSE
θ value	6.88961 (rank : 26)	NC score	0.063561 (rank : 28)
Query Neighborhood Hits	30	Target Neighborhood Hits	118	Shared Neighborhood Hits	19
SwissProt Accessions	Q91VY6, Q3TZH1, Q8R4T4, Q9QZA9	Gene names	Pscdbp
Domain Architecture	No domain graphic available
Description	Pleckstrin homology Sec7 and coiled-coil domains-binding protein (Cytohesin-binding protein HE) (Cbp).

ARMC6_MOUSE
θ value	8.99809 (rank : 27)	NC score	0.018332 (rank : 38)
Query Neighborhood Hits	30	Target Neighborhood Hits	28	Shared Neighborhood Hits	2
SwissProt Accessions	Q8BNU0, Q8C4P5, Q8C7S1, Q8K2S7, Q99JQ2, Q9CWE4	Gene names	Armc6
Domain Architecture	No domain graphic available
Description	Armadillo repeat-containing protein 6.

TX1B3_HUMAN
θ value	8.99809 (rank : 28)	NC score	0.070969 (rank : 23)
Query Neighborhood Hits	30	Target Neighborhood Hits	161	Shared Neighborhood Hits	21
SwissProt Accessions	O14907, Q7LCQ4	Gene names	TAX1BP3, TIP1
Domain Architecture	No domain graphic available
Description	Tax1-binding protein 3 (Tax interaction protein 1) (TIP-1) (Glutaminase-interacting protein 3).

TX1B3_MOUSE
θ value	8.99809 (rank : 29)	NC score	0.070827 (rank : 24)
Query Neighborhood Hits	30	Target Neighborhood Hits	158	Shared Neighborhood Hits	21
SwissProt Accessions	Q9DBG9	Gene names	Tax1bp3
Domain Architecture	No domain graphic available
Description	Tax1-binding protein 3 (Tax interaction protein 1) (TIP-1).

USH1C_HUMAN
θ value	8.99809 (rank : 30)	NC score	0.083297 (rank : 16)
Query Neighborhood Hits	30	Target Neighborhood Hits	327	Shared Neighborhood Hits	23
SwissProt Accessions	Q9Y6N9, Q96B29, Q9UM04, Q9UM17, Q9UPC3	Gene names	USH1C, AIE75
Domain Architecture
Description	Harmonin (Usher syndrome type-1C protein) (Autoimmune enteropathy- related antigen AIE-75) (Antigen NY-CO-38/NY-CO-37) (PDZ-73 protein) (NY-REN-3 antigen).

GRASP_HUMAN
θ value	θ > 10 (rank : 31)	NC score	0.053006 (rank : 32)
Query Neighborhood Hits	30	Target Neighborhood Hits	147	Shared Neighborhood Hits	20
SwissProt Accessions	Q7Z6J2, Q6PIF8, Q7Z741	Gene names	GRASP
Domain Architecture	No domain graphic available
Description	General receptor for phosphoinositides 1-associated scaffold protein (GRP1-associated scaffold protein).

GRASP_MOUSE
θ value	θ > 10 (rank : 32)	NC score	0.051889 (rank : 34)
Query Neighborhood Hits	30	Target Neighborhood Hits	131	Shared Neighborhood Hits	20
SwissProt Accessions	Q9JJA9, Q9JKL0	Gene names	Grasp
Domain Architecture	No domain graphic available
Description	General receptor for phosphoinositides 1-associated scaffold protein (GRP1-associated scaffold protein).

GRIP2_HUMAN
θ value	θ > 10 (rank : 33)	NC score	0.052308 (rank : 33)
Query Neighborhood Hits	30	Target Neighborhood Hits	256	Shared Neighborhood Hits	20
SwissProt Accessions	Q9C0E4, Q8TEH9, Q9H7H3	Gene names	GRIP2, KIAA1719
Domain Architecture
Description	Glutamate receptor-interacting protein 2 (GRIP2 protein).

NHERF_MOUSE
θ value	θ > 10 (rank : 34)	NC score	0.097971 (rank : 12)
Query Neighborhood Hits	30	Target Neighborhood Hits	195	Shared Neighborhood Hits	20
SwissProt Accessions	P70441	Gene names	Slc9a3r1, Nherf
Domain Architecture
Description	Ezrin-radixin-moesin-binding phosphoprotein 50 (EBP50) (Na(+)/H(+) exchange regulatory cofactor NHE-RF) (NHERF-1) (Regulatory cofactor of Na(+)/H(+) exchanger) (Sodium-hydrogen exchanger regulatory factor 1) (Solute carrier family 9 isoform 3 regulatory factor 1).

PDZD3_HUMAN
θ value	θ > 10 (rank : 35)	NC score	0.077677 (rank : 19)
Query Neighborhood Hits	30	Target Neighborhood Hits	180	Shared Neighborhood Hits	20
SwissProt Accessions	Q86UT5, Q8N6R4, Q8NAW7, Q8NEX7, Q9H5Z3	Gene names	PDZD3, IKEPP, PDZK2
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 3 (PDZ domain-containing protein 2) (Intestinal and kidney-enriched PDZ protein) (Protein DLNB27).

PDZD3_MOUSE
θ value	θ > 10 (rank : 36)	NC score	0.081492 (rank : 17)
Query Neighborhood Hits	30	Target Neighborhood Hits	171	Shared Neighborhood Hits	20
SwissProt Accessions	Q99MJ6, Q8BWE5	Gene names	Pdzd3, Pdzk2
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 3 (PDZ domain-containing protein 2) (Natrium-phosphate cotransporter IIa C-terminal-associated protein 2) (NaPi-Cap2).

PDZD7_HUMAN
θ value	θ > 10 (rank : 37)	NC score	0.063291 (rank : 29)
Query Neighborhood Hits	30	Target Neighborhood Hits	181	Shared Neighborhood Hits	19
SwissProt Accessions	Q9H5P4, Q8N321	Gene names	PDZD7, PDZK7
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 7.

USH1C_MOUSE
θ value	θ > 10 (rank : 38)	NC score	0.067791 (rank : 26)
Query Neighborhood Hits	30	Target Neighborhood Hits	557	Shared Neighborhood Hits	22
SwissProt Accessions	Q9ES64, Q91XD1, Q9CVG7, Q9ES65	Gene names	Ush1c
Domain Architecture
Description	Harmonin (Usher syndrome type-1C protein homolog) (PDZ domain- containing protein).

WHRN_HUMAN
θ value	θ > 10 (rank : 39)	NC score	0.071564 (rank : 22)
Query Neighborhood Hits	30	Target Neighborhood Hits	325	Shared Neighborhood Hits	22
SwissProt Accessions	Q9P202, Q96MZ9, Q9H9F4, Q9UFZ3	Gene names	WHRN, DFNB31, KIAA1526
Domain Architecture	No domain graphic available
Description	Whirlin (Autosomal recessive deafness type 31 protein).

Hits sorted by NC score

PSMD9_MOUSE
NC score	0.999962 (rank : 1)	θ value	2.45477e-106 (rank : 1)
Query Neighborhood Hits	30	Target Neighborhood Hits	30	Shared Neighborhood Hits	30
SwissProt Accessions	Q9CR00, Q3TG66	Gene names	Psmd9
Domain Architecture
Description	26S proteasome non-ATPase regulatory subunit 9 (26S proteasome regulatory subunit p27).

PSMD9_HUMAN
NC score	0.986541 (rank : 2)	θ value	1.75921e-104 (rank : 2)
Query Neighborhood Hits	30	Target Neighborhood Hits	36	Shared Neighborhood Hits	23
SwissProt Accessions	O00233, Q9BQ42	Gene names	PSMD9
Domain Architecture
Description	26S proteasome non-ATPase regulatory subunit 9 (26S proteasome regulatory subunit p27).

GR65_HUMAN
NC score	0.227977 (rank : 3)	θ value	0.00390308 (rank : 3)
Query Neighborhood Hits	30	Target Neighborhood Hits	148	Shared Neighborhood Hits	6
SwissProt Accessions	Q9BQQ3, Q8N272, Q96H42	Gene names	GORASP1, GRASP65
Domain Architecture	No domain graphic available
Description	Golgi reassembly-stacking protein 1 (Golgi reassembly-stacking protein of 65 kDa) (GRASP65) (Golgi peripheral membrane protein p65) (Golgi phosphoprotein 5) (GOLPH5).

GR65_MOUSE
NC score	0.223808 (rank : 4)	θ value	0.0113563 (rank : 4)
Query Neighborhood Hits	30	Target Neighborhood Hits	54	Shared Neighborhood Hits	6
SwissProt Accessions	Q91X51, Q9D3L9	Gene names	Gorasp1
Domain Architecture	No domain graphic available
Description	Golgi reassembly-stacking protein 1 (Golgi reassembly-stacking protein of 65 kDa) (GRASP65) (Golgi peripheral membrane protein p65).

GORS2_HUMAN
NC score	0.184822 (rank : 5)	θ value	0.365318 (rank : 8)
Query Neighborhood Hits	30	Target Neighborhood Hits	82	Shared Neighborhood Hits	7
SwissProt Accessions	Q9H8Y8, Q96I74, Q96K84, Q9H946, Q9UFW4	Gene names	GORASP2
Domain Architecture	No domain graphic available
Description	Golgi reassembly-stacking protein 2 (GRS2) (Golgi reassembly-stacking protein of 55 kDa) (GRASP55) (p59) (Golgi phosphoprotein 6) (GOLPH6).

GORS2_MOUSE
NC score	0.182196 (rank : 6)	θ value	0.365318 (rank : 9)
Query Neighborhood Hits	30	Target Neighborhood Hits	89	Shared Neighborhood Hits	6
SwissProt Accessions	Q99JX3, Q3U9D2, Q8CCD0, Q91W68	Gene names	Gorasp2
Domain Architecture	No domain graphic available
Description	Golgi reassembly-stacking protein 2 (GRS2) (Golgi reassembly-stacking protein of 55 kDa) (GRASP55).

NHRF2_MOUSE
NC score	0.157179 (rank : 7)	θ value	0.0113563 (rank : 5)
Query Neighborhood Hits	30	Target Neighborhood Hits	194	Shared Neighborhood Hits	22
SwissProt Accessions	Q9JHL1, Q3TDR3, Q8BGL9, Q8BW05, Q9DCR6	Gene names	Slc9a3r2, Nherf2
Domain Architecture
Description	Na(+)/H(+) exchange regulatory cofactor NHE-RF2 (NHERF-2) (Tyrosine kinase activator protein 1) (TKA-1) (SRY-interacting protein 1) (SIP- 1) (Solute carrier family 9 isoform A3 regulatory factor 2) (NHE3 kinase A regulatory protein E3KARP) (Sodium-hydrogen exchanger regulatory factor 2) (Octs2).

NHRF2_HUMAN
NC score	0.142604 (rank : 8)	θ value	0.125558 (rank : 6)
Query Neighborhood Hits	30	Target Neighborhood Hits	197	Shared Neighborhood Hits	22
SwissProt Accessions	Q15599, O00272, O00556	Gene names	SLC9A3R2, NHERF2
Domain Architecture
Description	Na(+)/H(+) exchange regulatory cofactor NHE-RF2 (NHERF-2) (Tyrosine kinase activator protein 1) (TKA-1) (SRY-interacting protein 1) (SIP- 1) (Solute carrier family 9 isoform A3 regulatory factor 2) (NHE3 kinase A regulatory protein E3KARP) (Sodium-hydrogen exchanger regulatory factor 2).

NHERF_HUMAN
NC score	0.129608 (rank : 9)	θ value	1.38821 (rank : 17)
Query Neighborhood Hits	30	Target Neighborhood Hits	190	Shared Neighborhood Hits	22
SwissProt Accessions	O14745, O43552, Q86WQ5	Gene names	SLC9A3R1, NHERF
Domain Architecture
Description	Ezrin-radixin-moesin-binding phosphoprotein 50 (EBP50) (Na(+)/H(+) exchange regulatory cofactor NHE-RF) (NHERF-1) (Regulatory cofactor of Na(+)/H(+) exchanger) (Sodium-hydrogen exchanger regulatory factor 1) (Solute carrier family 9 isoform 3 regulatory factor 1).

PDZD1_HUMAN
NC score	0.110355 (rank : 10)	θ value	0.62314 (rank : 10)
Query Neighborhood Hits	30	Target Neighborhood Hits	190	Shared Neighborhood Hits	23
SwissProt Accessions	Q5T2W1, O60450, Q5T5P6, Q9BQ41	Gene names	PDZK1, CAP70, NHERF3, PDZD1
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 1 (CFTR-associated protein of 70 kDa) (Na/Pi cotransporter C-terminal-associated protein) (NaPi-Cap1) (Na(+)/H(+) exchanger regulatory factor 3) (Sodium-hydrogen exchanger regulatory factor 3).

PDZD1_MOUSE
NC score	0.106718 (rank : 11)	θ value	6.88961 (rank : 25)
Query Neighborhood Hits	30	Target Neighborhood Hits	191	Shared Neighborhood Hits	22
SwissProt Accessions	Q9JIL4, Q8CDP5, Q8R4G2, Q9CQ72	Gene names	Pdzk1, Cap70, Nherf3
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 1 (CFTR-associated protein of 70 kDa) (Na/Pi cotransporter C-terminal-associated protein) (NaPi-Cap1) (Na(+)/H(+) exchanger regulatory factor 3) (Sodium-hydrogen exchanger regulatory factor 3).

NHERF_MOUSE
NC score	0.097971 (rank : 12)	θ value	θ > 10 (rank : 34)
Query Neighborhood Hits	30	Target Neighborhood Hits	195	Shared Neighborhood Hits	20
SwissProt Accessions	P70441	Gene names	Slc9a3r1, Nherf
Domain Architecture
Description	Ezrin-radixin-moesin-binding phosphoprotein 50 (EBP50) (Na(+)/H(+) exchange regulatory cofactor NHE-RF) (NHERF-1) (Regulatory cofactor of Na(+)/H(+) exchanger) (Sodium-hydrogen exchanger regulatory factor 1) (Solute carrier family 9 isoform 3 regulatory factor 1).

INADL_HUMAN
NC score	0.093568 (rank : 13)	θ value	1.06291 (rank : 12)
Query Neighborhood Hits	30	Target Neighborhood Hits	260	Shared Neighborhood Hits	21
SwissProt Accessions	Q8NI35, O15249, O43742, O60833, Q5VUA5, Q5VUA6, Q5VUA7, Q5VUA8, Q5VUA9, Q5VUB0, Q8WU78, Q9H3N9	Gene names	INADL, PATJ
Domain Architecture	No domain graphic available
Description	InaD-like protein (Inadl protein) (hINADL) (Pals1-associated tight junction protein) (Protein associated to tight junctions).

INADL_MOUSE
NC score	0.093257 (rank : 14)	θ value	0.279714 (rank : 7)
Query Neighborhood Hits	30	Target Neighborhood Hits	290	Shared Neighborhood Hits	21
SwissProt Accessions	Q63ZW7, O70471, Q5PRG3, Q6P6J1, Q80YR8, Q8BPB9	Gene names	Inadl, Cipp, Patj
Domain Architecture	No domain graphic available
Description	InaD-like protein (Inadl protein) (Pals1-associated tight junction protein) (Protein associated to tight junctions) (Channel-interacting PDZ domain-containing protein).

WHRN_MOUSE
NC score	0.090382 (rank : 15)	θ value	0.813845 (rank : 11)
Query Neighborhood Hits	30	Target Neighborhood Hits	412	Shared Neighborhood Hits	23
SwissProt Accessions	Q80VW5, Q80TC2, Q80VW4	Gene names	Whrn, Kiaa1526
Domain Architecture	No domain graphic available
Description	Whirlin.

USH1C_HUMAN
NC score	0.083297 (rank : 16)	θ value	8.99809 (rank : 30)
Query Neighborhood Hits	30	Target Neighborhood Hits	327	Shared Neighborhood Hits	23
SwissProt Accessions	Q9Y6N9, Q96B29, Q9UM04, Q9UM17, Q9UPC3	Gene names	USH1C, AIE75
Domain Architecture
Description	Harmonin (Usher syndrome type-1C protein) (Autoimmune enteropathy- related antigen AIE-75) (Antigen NY-CO-38/NY-CO-37) (PDZ-73 protein) (NY-REN-3 antigen).

PDZD3_MOUSE
NC score	0.081492 (rank : 17)	θ value	θ > 10 (rank : 36)
Query Neighborhood Hits	30	Target Neighborhood Hits	171	Shared Neighborhood Hits	20
SwissProt Accessions	Q99MJ6, Q8BWE5	Gene names	Pdzd3, Pdzk2
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 3 (PDZ domain-containing protein 2) (Natrium-phosphate cotransporter IIa C-terminal-associated protein 2) (NaPi-Cap2).

MPDZ_HUMAN
NC score	0.077908 (rank : 18)	θ value	1.06291 (rank : 13)
Query Neighborhood Hits	30	Target Neighborhood Hits	261	Shared Neighborhood Hits	23
SwissProt Accessions	O75970, O43798, Q5CZ80, Q5JTX3, Q5JTX6, Q5JTX7, Q5JUC3, Q5JUC4, Q5VZ62, Q8N790	Gene names	MPDZ, MUPP1
Domain Architecture	No domain graphic available
Description	Multiple PDZ domain protein (Multi PDZ domain protein 1) (Multi-PDZ- domain protein 1).

PDZD3_HUMAN
NC score	0.077677 (rank : 19)	θ value	θ > 10 (rank : 35)
Query Neighborhood Hits	30	Target Neighborhood Hits	180	Shared Neighborhood Hits	20
SwissProt Accessions	Q86UT5, Q8N6R4, Q8NAW7, Q8NEX7, Q9H5Z3	Gene names	PDZD3, IKEPP, PDZK2
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 3 (PDZ domain-containing protein 2) (Intestinal and kidney-enriched PDZ protein) (Protein DLNB27).

MPDZ_MOUSE
NC score	0.075170 (rank : 20)	θ value	4.03905 (rank : 19)
Query Neighborhood Hits	30	Target Neighborhood Hits	298	Shared Neighborhood Hits	22
SwissProt Accessions	Q8VBX6, O08783, Q6P7U4, Q80ZY8, Q8BKJ1, Q8C0H8, Q8VBV5, Q8VBY0, Q9Z1K3	Gene names	Mpdz, Mupp1
Domain Architecture	No domain graphic available
Description	Multiple PDZ domain protein (Multi PDZ domain protein 1) (Multi-PDZ domain protein 1).

RPGF2_HUMAN
NC score	0.071566 (rank : 21)	θ value	1.06291 (rank : 15)
Query Neighborhood Hits	30	Target Neighborhood Hits	242	Shared Neighborhood Hits	20
SwissProt Accessions	Q9Y4G8	Gene names	RAPGEF2, KIAA0313, NRAPGEP, PDZGEF1
Domain Architecture	No domain graphic available
Description	Rap guanine nucleotide exchange factor 2 (Neural RAP guanine nucleotide exchange protein) (nRap GEP) (PDZ domain-containing guanine nucleotide exchange factor 1) (PDZ-GEF1) (RA-GEF).

WHRN_HUMAN
NC score	0.071564 (rank : 22)	θ value	θ > 10 (rank : 39)
Query Neighborhood Hits	30	Target Neighborhood Hits	325	Shared Neighborhood Hits	22
SwissProt Accessions	Q9P202, Q96MZ9, Q9H9F4, Q9UFZ3	Gene names	WHRN, DFNB31, KIAA1526
Domain Architecture	No domain graphic available
Description	Whirlin (Autosomal recessive deafness type 31 protein).

TX1B3_HUMAN
NC score	0.070969 (rank : 23)	θ value	8.99809 (rank : 28)
Query Neighborhood Hits	30	Target Neighborhood Hits	161	Shared Neighborhood Hits	21
SwissProt Accessions	O14907, Q7LCQ4	Gene names	TAX1BP3, TIP1
Domain Architecture	No domain graphic available
Description	Tax1-binding protein 3 (Tax interaction protein 1) (TIP-1) (Glutaminase-interacting protein 3).

TX1B3_MOUSE
NC score	0.070827 (rank : 24)	θ value	8.99809 (rank : 29)
Query Neighborhood Hits	30	Target Neighborhood Hits	158	Shared Neighborhood Hits	21
SwissProt Accessions	Q9DBG9	Gene names	Tax1bp3
Domain Architecture	No domain graphic available
Description	Tax1-binding protein 3 (Tax interaction protein 1) (TIP-1).

RPGF6_HUMAN
NC score	0.068513 (rank : 25)	θ value	4.03905 (rank : 20)
Query Neighborhood Hits	30	Target Neighborhood Hits	266	Shared Neighborhood Hits	21
SwissProt Accessions	Q8TEU7, Q8NI21, Q8TEU6, Q96PC1	Gene names	RAPGEF6, PDZGEF2
Domain Architecture
Description	Rap guanine nucleotide exchange factor 6 (PDZ domain-containing guanine nucleotide exchange factor 2) (PDZ-GEF2) (RA-GEF-2).

USH1C_MOUSE
NC score	0.067791 (rank : 26)	θ value	θ > 10 (rank : 38)
Query Neighborhood Hits	30	Target Neighborhood Hits	557	Shared Neighborhood Hits	22
SwissProt Accessions	Q9ES64, Q91XD1, Q9CVG7, Q9ES65	Gene names	Ush1c
Domain Architecture
Description	Harmonin (Usher syndrome type-1C protein homolog) (PDZ domain- containing protein).

PSCBP_HUMAN
NC score	0.064624 (rank : 27)	θ value	5.27518 (rank : 21)
Query Neighborhood Hits	30	Target Neighborhood Hits	123	Shared Neighborhood Hits	20
SwissProt Accessions	O60759, Q15630, Q8NE32	Gene names	PSCDBP, CYTIP
Domain Architecture	No domain graphic available
Description	Pleckstrin homology Sec7 and coiled-coil domains-binding protein (Cytohesin-binding protein HE) (CYBR) (Cytohesin binder and regulator) (Cytohesin-interacting protein).

PSCBP_MOUSE
NC score	0.063561 (rank : 28)	θ value	6.88961 (rank : 26)
Query Neighborhood Hits	30	Target Neighborhood Hits	118	Shared Neighborhood Hits	19
SwissProt Accessions	Q91VY6, Q3TZH1, Q8R4T4, Q9QZA9	Gene names	Pscdbp
Domain Architecture	No domain graphic available
Description	Pleckstrin homology Sec7 and coiled-coil domains-binding protein (Cytohesin-binding protein HE) (Cbp).

PDZD7_HUMAN
NC score	0.063291 (rank : 29)	θ value	θ > 10 (rank : 37)
Query Neighborhood Hits	30	Target Neighborhood Hits	181	Shared Neighborhood Hits	19
SwissProt Accessions	Q9H5P4, Q8N321	Gene names	PDZD7, PDZK7
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 7.

PDLI1_HUMAN
NC score	0.056339 (rank : 30)	θ value	1.06291 (rank : 14)
Query Neighborhood Hits	30	Target Neighborhood Hits	242	Shared Neighborhood Hits	18
SwissProt Accessions	O00151, Q5VZH5, Q9BPZ9	Gene names	PDLIM1, CLIM1, CLP36
Domain Architecture
Description	PDZ and LIM domain protein 1 (Elfin) (LIM domain protein CLP-36) (C- terminal LIM domain protein 1).

HTRA1_HUMAN
NC score	0.053935 (rank : 31)	θ value	1.38821 (rank : 16)
Query Neighborhood Hits	30	Target Neighborhood Hits	155	Shared Neighborhood Hits	14
SwissProt Accessions	Q92743, Q9UNS5	Gene names	HTRA1, HTRA, PRSS11
Domain Architecture
Description	Serine protease HTRA1 precursor (EC 3.4.21.-) (L56).

GRASP_HUMAN
NC score	0.053006 (rank : 32)	θ value	θ > 10 (rank : 31)
Query Neighborhood Hits	30	Target Neighborhood Hits	147	Shared Neighborhood Hits	20
SwissProt Accessions	Q7Z6J2, Q6PIF8, Q7Z741	Gene names	GRASP
Domain Architecture	No domain graphic available
Description	General receptor for phosphoinositides 1-associated scaffold protein (GRP1-associated scaffold protein).

GRIP2_HUMAN
NC score	0.052308 (rank : 33)	θ value	θ > 10 (rank : 33)
Query Neighborhood Hits	30	Target Neighborhood Hits	256	Shared Neighborhood Hits	20
SwissProt Accessions	Q9C0E4, Q8TEH9, Q9H7H3	Gene names	GRIP2, KIAA1719
Domain Architecture
Description	Glutamate receptor-interacting protein 2 (GRIP2 protein).

GRASP_MOUSE
NC score	0.051889 (rank : 34)	θ value	θ > 10 (rank : 32)
Query Neighborhood Hits	30	Target Neighborhood Hits	131	Shared Neighborhood Hits	20
SwissProt Accessions	Q9JJA9, Q9JKL0	Gene names	Grasp
Domain Architecture	No domain graphic available
Description	General receptor for phosphoinositides 1-associated scaffold protein (GRP1-associated scaffold protein).

HTRA1_MOUSE
NC score	0.042199 (rank : 35)	θ value	6.88961 (rank : 23)
Query Neighborhood Hits	30	Target Neighborhood Hits	140	Shared Neighborhood Hits	15
SwissProt Accessions	Q9R118	Gene names	Htra1, Htra, Prss11
Domain Architecture
Description	Serine protease HTRA1 precursor (EC 3.4.21.-).

LMO7_HUMAN
NC score	0.036763 (rank : 36)	θ value	6.88961 (rank : 24)
Query Neighborhood Hits	30	Target Neighborhood Hits	507	Shared Neighborhood Hits	15
SwissProt Accessions	Q8WWI1, O15462, O95346, Q9UKC1, Q9UQM5, Q9Y6A7	Gene names	LMO7, FBX20, FBXO20, KIAA0858
Domain Architecture
Description	LIM domain only protein 7 (LOMP) (F-box only protein 20).

CUL5_HUMAN
NC score	0.020802 (rank : 37)	θ value	3.0926 (rank : 18)
Query Neighborhood Hits	30	Target Neighborhood Hits	46	Shared Neighborhood Hits	2
SwissProt Accessions	Q93034, O14766, Q9BZC6	Gene names	CUL5, VACM1
Domain Architecture
Description	Cullin-5 (CUL-5) (Vasopressin-activated calcium-mobilizing receptor) (VACM-1).

ARMC6_MOUSE
NC score	0.018332 (rank : 38)	θ value	8.99809 (rank : 27)
Query Neighborhood Hits	30	Target Neighborhood Hits	28	Shared Neighborhood Hits	2
SwissProt Accessions	Q8BNU0, Q8C4P5, Q8C7S1, Q8K2S7, Q99JQ2, Q9CWE4	Gene names	Armc6
Domain Architecture	No domain graphic available
Description	Armadillo repeat-containing protein 6.

SRGP1_HUMAN
NC score	0.010985 (rank : 39)	θ value	5.27518 (rank : 22)
Query Neighborhood Hits	30	Target Neighborhood Hits	390	Shared Neighborhood Hits	2
SwissProt Accessions	Q7Z6B7, Q9H8A3, Q9P2P2	Gene names	SRGAP1, ARHGAP13, KIAA1304
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 1 (srGAP1) (Rho-GTPase- activating protein 13).