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Network neighborhood for query Sequence : PLD1_HUMAN

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PLD1_HUMAN
SwissProt Accessions	Q13393	Gene names	PLD1
Domain Architecture
Description	Phospholipase D1 (EC 3.1.4.4) (PLD 1) (Choline phosphatase 1) (Phosphatidylcholine-hydrolyzing phospholipase D1) (hPLD1).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

PLD1_HUMAN
θ value	0 (rank : 1)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	18	Target Neighborhood Hits	18	Shared Neighborhood Hits	18
SwissProt Accessions	Q13393	Gene names	PLD1
Domain Architecture
Description	Phospholipase D1 (EC 3.1.4.4) (PLD 1) (Choline phosphatase 1) (Phosphatidylcholine-hydrolyzing phospholipase D1) (hPLD1).

PLD1_MOUSE
θ value	0 (rank : 2)	NC score	0.998306 (rank : 2)
Query Neighborhood Hits	18	Target Neighborhood Hits	23	Shared Neighborhood Hits	12
SwissProt Accessions	Q9Z280, O35911	Gene names	Pld1
Domain Architecture
Description	Phospholipase D1 (EC 3.1.4.4) (PLD 1) (Choline phosphatase 1) (Phosphatidylcholine-hydrolyzing phospholipase D1) (mPLD1).

PLD2_MOUSE
θ value	1.79118e-157 (rank : 3)	NC score	0.939116 (rank : 3)
Query Neighborhood Hits	18	Target Neighborhood Hits	12	Shared Neighborhood Hits	6
SwissProt Accessions	P97813	Gene names	Pld2
Domain Architecture
Description	Phospholipase D2 (EC 3.1.4.4) (PLD 2) (Choline phosphatase 2) (Phosphatidylcholine-hydrolyzing phospholipase D2) (PLD1C) (mPLD2).

PLD2_HUMAN
θ value	5.76203e-156 (rank : 4)	NC score	0.938320 (rank : 4)
Query Neighborhood Hits	18	Target Neighborhood Hits	15	Shared Neighborhood Hits	4
SwissProt Accessions	O14939, O43540, O43579, O43580, Q96BY3	Gene names	PLD2
Domain Architecture
Description	Phospholipase D2 (EC 3.1.4.4) (PLD 2) (Choline phosphatase 2) (Phosphatidylcholine-hydrolyzing phospholipase D2) (PLD1C) (hPLD2).

CENB1_HUMAN
θ value	0.279714 (rank : 5)	NC score	0.038474 (rank : 8)
Query Neighborhood Hits	18	Target Neighborhood Hits	383	Shared Neighborhood Hits	5
SwissProt Accessions	Q15027	Gene names	CENTB1, KIAA0050
Domain Architecture
Description	Centaurin-beta 1 (Cnt-b1).

NUFP2_HUMAN
θ value	0.62314 (rank : 6)	NC score	0.052009 (rank : 5)
Query Neighborhood Hits	18	Target Neighborhood Hits	62	Shared Neighborhood Hits	3
SwissProt Accessions	Q7Z417, Q9P2M5	Gene names	NUFIP2, KIAA1321, PIG1
Domain Architecture	No domain graphic available
Description	Nuclear fragile X mental retardation-interacting protein 2 (FMRP- interacting protein 2) (82 kDa FMRP-interacting protein) (82-FIP) (Proliferation-inducing gene 1 protein).

NUFP2_MOUSE
θ value	0.813845 (rank : 7)	NC score	0.050663 (rank : 6)
Query Neighborhood Hits	18	Target Neighborhood Hits	53	Shared Neighborhood Hits	3
SwissProt Accessions	Q5F2E7, Q3TCE2, Q3V195, Q80TF1	Gene names	Nufip2, Kiaa1321
Domain Architecture	No domain graphic available
Description	Nuclear fragile X mental retardation-interacting protein 2 (FMRP- interacting protein 2) (82 kDa FMRP-interacting protein) (82-FIP).

SYNE2_HUMAN
θ value	2.36792 (rank : 8)	NC score	0.010113 (rank : 14)
Query Neighborhood Hits	18	Target Neighborhood Hits	1323	Shared Neighborhood Hits	5
SwissProt Accessions	Q8WXH0, Q8N1S3, Q8NF49, Q8TER7, Q8WWW3, Q8WWW4, Q8WWW5, Q8WXH1, Q9NU50, Q9UFQ4, Q9Y2L4, Q9Y4R1	Gene names	SYNE2, KIAA1011, NUA
Domain Architecture
Description	Nesprin-2 (Nuclear envelope spectrin repeat protein 2) (Syne-2) (Synaptic nuclear envelope protein 2) (Nucleus and actin connecting element protein) (Protein NUANCE).

DNL3_HUMAN
θ value	3.0926 (rank : 9)	NC score	0.027747 (rank : 9)
Query Neighborhood Hits	18	Target Neighborhood Hits	49	Shared Neighborhood Hits	3
SwissProt Accessions	P49916, Q16714	Gene names	LIG3
Domain Architecture
Description	DNA ligase 3 (EC 6.5.1.1) (DNA ligase III) (Polydeoxyribonucleotide synthase [ATP] 3).

CP250_HUMAN
θ value	5.27518 (rank : 10)	NC score	0.003096 (rank : 17)
Query Neighborhood Hits	18	Target Neighborhood Hits	1805	Shared Neighborhood Hits	5
SwissProt Accessions	Q9BV73, O14812, O60588, Q9H450	Gene names	CEP250, CEP2, CNAP1
Domain Architecture
Description	Centrosome-associated protein CEP250 (Centrosomal protein 2) (Centrosomal Nek2-associated protein 1) (C-Nap1).

P3C2G_HUMAN
θ value	5.27518 (rank : 11)	NC score	0.014457 (rank : 11)
Query Neighborhood Hits	18	Target Neighborhood Hits	92	Shared Neighborhood Hits	4
SwissProt Accessions	O75747	Gene names	PIK3C2G
Domain Architecture
Description	Phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing gamma polypeptide (EC 2.7.1.154) (Phosphoinositide 3-Kinase-C2-gamma) (PtdIns-3-kinase C2 gamma) (PI3K-C2gamma).

SNX14_HUMAN
θ value	5.27518 (rank : 12)	NC score	0.020518 (rank : 10)
Query Neighborhood Hits	18	Target Neighborhood Hits	77	Shared Neighborhood Hits	4
SwissProt Accessions	Q9Y5W7, Q9BSD1	Gene names	SNX14
Domain Architecture
Description	Sorting nexin-14.

SNX27_HUMAN
θ value	5.27518 (rank : 13)	NC score	0.046705 (rank : 7)
Query Neighborhood Hits	18	Target Neighborhood Hits	54	Shared Neighborhood Hits	5
SwissProt Accessions	Q96L92	Gene names	SNX27
Domain Architecture
Description	Sorting nexin-27.

AT8A1_HUMAN
θ value	6.88961 (rank : 14)	NC score	0.004798 (rank : 16)
Query Neighborhood Hits	18	Target Neighborhood Hits	61	Shared Neighborhood Hits	2
SwissProt Accessions	Q9Y2Q0	Gene names	ATP8A1, ATPIA
Domain Architecture
Description	Probable phospholipid-transporting ATPase IA (EC 3.6.3.1) (Chromaffin granule ATPase II) (ATPase class I type 8A member 1).

CP39A_MOUSE
θ value	6.88961 (rank : 15)	NC score	0.012164 (rank : 13)
Query Neighborhood Hits	18	Target Neighborhood Hits	116	Shared Neighborhood Hits	3
SwissProt Accessions	Q9JKJ9	Gene names	Cyp39a1
Domain Architecture
Description	Cytochrome P450 39A1 (EC 1.14.13.99) (24-hydroxycholesterol 7-alpha- hydroxylase) (Oxysterol 7-alpha-hydroxylase) (mCYP39A1).

TRHY_HUMAN
θ value	6.88961 (rank : 16)	NC score	0.002503 (rank : 18)
Query Neighborhood Hits	18	Target Neighborhood Hits	1385	Shared Neighborhood Hits	4
SwissProt Accessions	Q07283	Gene names	THH, THL, TRHY
Domain Architecture
Description	Trichohyalin.

CENB5_HUMAN
θ value	8.99809 (rank : 17)	NC score	0.012459 (rank : 12)
Query Neighborhood Hits	18	Target Neighborhood Hits	395	Shared Neighborhood Hits	4
SwissProt Accessions	Q96P50, Q9BSR9, Q9C0E7	Gene names	CENTB5, KIAA1716
Domain Architecture
Description	Centaurin-beta 5 (Cnt-b5).

FA8_MOUSE
θ value	8.99809 (rank : 18)	NC score	0.008229 (rank : 15)
Query Neighborhood Hits	18	Target Neighborhood Hits	100	Shared Neighborhood Hits	4
SwissProt Accessions	Q06194	Gene names	F8, Cf8, F8c
Domain Architecture
Description	Coagulation factor VIII precursor (Procoagulant component).

Hits sorted by NC score

PLD1_HUMAN
NC score	0.999962 (rank : 1)	θ value	0 (rank : 1)
Query Neighborhood Hits	18	Target Neighborhood Hits	18	Shared Neighborhood Hits	18
SwissProt Accessions	Q13393	Gene names	PLD1
Domain Architecture
Description	Phospholipase D1 (EC 3.1.4.4) (PLD 1) (Choline phosphatase 1) (Phosphatidylcholine-hydrolyzing phospholipase D1) (hPLD1).

PLD1_MOUSE
NC score	0.998306 (rank : 2)	θ value	0 (rank : 2)
Query Neighborhood Hits	18	Target Neighborhood Hits	23	Shared Neighborhood Hits	12
SwissProt Accessions	Q9Z280, O35911	Gene names	Pld1
Domain Architecture
Description	Phospholipase D1 (EC 3.1.4.4) (PLD 1) (Choline phosphatase 1) (Phosphatidylcholine-hydrolyzing phospholipase D1) (mPLD1).

PLD2_MOUSE
NC score	0.939116 (rank : 3)	θ value	1.79118e-157 (rank : 3)
Query Neighborhood Hits	18	Target Neighborhood Hits	12	Shared Neighborhood Hits	6
SwissProt Accessions	P97813	Gene names	Pld2
Domain Architecture
Description	Phospholipase D2 (EC 3.1.4.4) (PLD 2) (Choline phosphatase 2) (Phosphatidylcholine-hydrolyzing phospholipase D2) (PLD1C) (mPLD2).

PLD2_HUMAN
NC score	0.938320 (rank : 4)	θ value	5.76203e-156 (rank : 4)
Query Neighborhood Hits	18	Target Neighborhood Hits	15	Shared Neighborhood Hits	4
SwissProt Accessions	O14939, O43540, O43579, O43580, Q96BY3	Gene names	PLD2
Domain Architecture
Description	Phospholipase D2 (EC 3.1.4.4) (PLD 2) (Choline phosphatase 2) (Phosphatidylcholine-hydrolyzing phospholipase D2) (PLD1C) (hPLD2).

NUFP2_HUMAN
NC score	0.052009 (rank : 5)	θ value	0.62314 (rank : 6)
Query Neighborhood Hits	18	Target Neighborhood Hits	62	Shared Neighborhood Hits	3
SwissProt Accessions	Q7Z417, Q9P2M5	Gene names	NUFIP2, KIAA1321, PIG1
Domain Architecture	No domain graphic available
Description	Nuclear fragile X mental retardation-interacting protein 2 (FMRP- interacting protein 2) (82 kDa FMRP-interacting protein) (82-FIP) (Proliferation-inducing gene 1 protein).

NUFP2_MOUSE
NC score	0.050663 (rank : 6)	θ value	0.813845 (rank : 7)
Query Neighborhood Hits	18	Target Neighborhood Hits	53	Shared Neighborhood Hits	3
SwissProt Accessions	Q5F2E7, Q3TCE2, Q3V195, Q80TF1	Gene names	Nufip2, Kiaa1321
Domain Architecture	No domain graphic available
Description	Nuclear fragile X mental retardation-interacting protein 2 (FMRP- interacting protein 2) (82 kDa FMRP-interacting protein) (82-FIP).

SNX27_HUMAN
NC score	0.046705 (rank : 7)	θ value	5.27518 (rank : 13)
Query Neighborhood Hits	18	Target Neighborhood Hits	54	Shared Neighborhood Hits	5
SwissProt Accessions	Q96L92	Gene names	SNX27
Domain Architecture
Description	Sorting nexin-27.

CENB1_HUMAN
NC score	0.038474 (rank : 8)	θ value	0.279714 (rank : 5)
Query Neighborhood Hits	18	Target Neighborhood Hits	383	Shared Neighborhood Hits	5
SwissProt Accessions	Q15027	Gene names	CENTB1, KIAA0050
Domain Architecture
Description	Centaurin-beta 1 (Cnt-b1).

DNL3_HUMAN
NC score	0.027747 (rank : 9)	θ value	3.0926 (rank : 9)
Query Neighborhood Hits	18	Target Neighborhood Hits	49	Shared Neighborhood Hits	3
SwissProt Accessions	P49916, Q16714	Gene names	LIG3
Domain Architecture
Description	DNA ligase 3 (EC 6.5.1.1) (DNA ligase III) (Polydeoxyribonucleotide synthase [ATP] 3).

SNX14_HUMAN
NC score	0.020518 (rank : 10)	θ value	5.27518 (rank : 12)
Query Neighborhood Hits	18	Target Neighborhood Hits	77	Shared Neighborhood Hits	4
SwissProt Accessions	Q9Y5W7, Q9BSD1	Gene names	SNX14
Domain Architecture
Description	Sorting nexin-14.

P3C2G_HUMAN
NC score	0.014457 (rank : 11)	θ value	5.27518 (rank : 11)
Query Neighborhood Hits	18	Target Neighborhood Hits	92	Shared Neighborhood Hits	4
SwissProt Accessions	O75747	Gene names	PIK3C2G
Domain Architecture
Description	Phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing gamma polypeptide (EC 2.7.1.154) (Phosphoinositide 3-Kinase-C2-gamma) (PtdIns-3-kinase C2 gamma) (PI3K-C2gamma).

CENB5_HUMAN
NC score	0.012459 (rank : 12)	θ value	8.99809 (rank : 17)
Query Neighborhood Hits	18	Target Neighborhood Hits	395	Shared Neighborhood Hits	4
SwissProt Accessions	Q96P50, Q9BSR9, Q9C0E7	Gene names	CENTB5, KIAA1716
Domain Architecture
Description	Centaurin-beta 5 (Cnt-b5).

CP39A_MOUSE
NC score	0.012164 (rank : 13)	θ value	6.88961 (rank : 15)
Query Neighborhood Hits	18	Target Neighborhood Hits	116	Shared Neighborhood Hits	3
SwissProt Accessions	Q9JKJ9	Gene names	Cyp39a1
Domain Architecture
Description	Cytochrome P450 39A1 (EC 1.14.13.99) (24-hydroxycholesterol 7-alpha- hydroxylase) (Oxysterol 7-alpha-hydroxylase) (mCYP39A1).

SYNE2_HUMAN
NC score	0.010113 (rank : 14)	θ value	2.36792 (rank : 8)
Query Neighborhood Hits	18	Target Neighborhood Hits	1323	Shared Neighborhood Hits	5
SwissProt Accessions	Q8WXH0, Q8N1S3, Q8NF49, Q8TER7, Q8WWW3, Q8WWW4, Q8WWW5, Q8WXH1, Q9NU50, Q9UFQ4, Q9Y2L4, Q9Y4R1	Gene names	SYNE2, KIAA1011, NUA
Domain Architecture
Description	Nesprin-2 (Nuclear envelope spectrin repeat protein 2) (Syne-2) (Synaptic nuclear envelope protein 2) (Nucleus and actin connecting element protein) (Protein NUANCE).

FA8_MOUSE
NC score	0.008229 (rank : 15)	θ value	8.99809 (rank : 18)
Query Neighborhood Hits	18	Target Neighborhood Hits	100	Shared Neighborhood Hits	4
SwissProt Accessions	Q06194	Gene names	F8, Cf8, F8c
Domain Architecture
Description	Coagulation factor VIII precursor (Procoagulant component).

AT8A1_HUMAN
NC score	0.004798 (rank : 16)	θ value	6.88961 (rank : 14)
Query Neighborhood Hits	18	Target Neighborhood Hits	61	Shared Neighborhood Hits	2
SwissProt Accessions	Q9Y2Q0	Gene names	ATP8A1, ATPIA
Domain Architecture
Description	Probable phospholipid-transporting ATPase IA (EC 3.6.3.1) (Chromaffin granule ATPase II) (ATPase class I type 8A member 1).

CP250_HUMAN
NC score	0.003096 (rank : 17)	θ value	5.27518 (rank : 10)
Query Neighborhood Hits	18	Target Neighborhood Hits	1805	Shared Neighborhood Hits	5
SwissProt Accessions	Q9BV73, O14812, O60588, Q9H450	Gene names	CEP250, CEP2, CNAP1
Domain Architecture
Description	Centrosome-associated protein CEP250 (Centrosomal protein 2) (Centrosomal Nek2-associated protein 1) (C-Nap1).

TRHY_HUMAN
NC score	0.002503 (rank : 18)	θ value	6.88961 (rank : 16)
Query Neighborhood Hits	18	Target Neighborhood Hits	1385	Shared Neighborhood Hits	4
SwissProt Accessions	Q07283	Gene names	THH, THL, TRHY
Domain Architecture
Description	Trichohyalin.