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Network neighborhood for query Sequence : PDK2_HUMAN

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PDK2_HUMAN
SwissProt Accessions	Q15119, Q9BS05	Gene names	PDK2
Domain Architecture
Description	[Pyruvate dehydrogenase [lipoamide]] kinase isozyme 2, mitochondrial precursor (EC 2.7.11.2) (Pyruvate dehydrogenase kinase isoform 2).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

PDK2_HUMAN
θ value	0 (rank : 1)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	13	Target Neighborhood Hits	13	Shared Neighborhood Hits	13
SwissProt Accessions	Q15119, Q9BS05	Gene names	PDK2
Domain Architecture
Description	[Pyruvate dehydrogenase [lipoamide]] kinase isozyme 2, mitochondrial precursor (EC 2.7.11.2) (Pyruvate dehydrogenase kinase isoform 2).

PDK2_MOUSE
θ value	0 (rank : 2)	NC score	0.999917 (rank : 2)
Query Neighborhood Hits	13	Target Neighborhood Hits	14	Shared Neighborhood Hits	13
SwissProt Accessions	Q9JK42	Gene names	Pdk2
Domain Architecture
Description	[Pyruvate dehydrogenase [lipoamide]] kinase isozyme 2, mitochondrial precursor (EC 2.7.11.2) (Pyruvate dehydrogenase kinase isoform 2).

PDK1_MOUSE
θ value	5.55514e-167 (rank : 3)	NC score	0.997236 (rank : 4)
Query Neighborhood Hits	13	Target Neighborhood Hits	14	Shared Neighborhood Hits	11
SwissProt Accessions	Q8BFP9	Gene names	Pdk1
Domain Architecture	No domain graphic available
Description	[Pyruvate dehydrogenase [lipoamide]] kinase isozyme 1, mitochondrial precursor (EC 2.7.11.2) (Pyruvate dehydrogenase kinase isoform 1).

PDK1_HUMAN
θ value	1.6163e-166 (rank : 4)	NC score	0.997570 (rank : 3)
Query Neighborhood Hits	13	Target Neighborhood Hits	13	Shared Neighborhood Hits	11
SwissProt Accessions	Q15118	Gene names	PDK1
Domain Architecture
Description	[Pyruvate dehydrogenase [lipoamide]] kinase isozyme 1, mitochondrial precursor (EC 2.7.11.2) (Pyruvate dehydrogenase kinase isoform 1).

PDK3_MOUSE
θ value	8.30107e-163 (rank : 5)	NC score	0.996611 (rank : 6)
Query Neighborhood Hits	13	Target Neighborhood Hits	17	Shared Neighborhood Hits	10
SwissProt Accessions	Q922H2, Q8BTX1	Gene names	Pdk3
Domain Architecture	No domain graphic available
Description	[Pyruvate dehydrogenase [lipoamide]] kinase isozyme 3, mitochondrial precursor (EC 2.7.11.2) (Pyruvate dehydrogenase kinase isoform 3).

PDK3_HUMAN
θ value	6.57732e-160 (rank : 6)	NC score	0.996539 (rank : 7)
Query Neighborhood Hits	13	Target Neighborhood Hits	17	Shared Neighborhood Hits	10
SwissProt Accessions	Q15120	Gene names	PDK3
Domain Architecture
Description	[Pyruvate dehydrogenase [lipoamide]] kinase isozyme 3, mitochondrial precursor (EC 2.7.11.2) (Pyruvate dehydrogenase kinase isoform 3).

PDK4_MOUSE
θ value	2.76339e-158 (rank : 7)	NC score	0.996507 (rank : 8)
Query Neighborhood Hits	13	Target Neighborhood Hits	18	Shared Neighborhood Hits	10
SwissProt Accessions	O70571	Gene names	Pdk4
Domain Architecture
Description	[Pyruvate dehydrogenase [lipoamide]] kinase isozyme 4, mitochondrial precursor (EC 2.7.11.2) (Pyruvate dehydrogenase kinase isoform 4).

PDK4_HUMAN
θ value	8.88953e-157 (rank : 8)	NC score	0.996612 (rank : 5)
Query Neighborhood Hits	13	Target Neighborhood Hits	11	Shared Neighborhood Hits	10
SwissProt Accessions	Q16654	Gene names	PDK4
Domain Architecture
Description	[Pyruvate dehydrogenase [lipoamide]] kinase isozyme 4, mitochondrial precursor (EC 2.7.11.2) (Pyruvate dehydrogenase kinase isoform 4).

BCKD_HUMAN
θ value	2.26708e-35 (rank : 9)	NC score	0.874233 (rank : 9)
Query Neighborhood Hits	13	Target Neighborhood Hits	15	Shared Neighborhood Hits	10
SwissProt Accessions	O14874, Q96IN5	Gene names	BCKDK
Domain Architecture
Description	[3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial precursor (EC 2.7.11.4) (Branched-chain alpha-ketoacid dehydrogenase kinase) (BCKDHKIN) (BCKD-kinase).

BCKD_MOUSE
θ value	5.0505e-35 (rank : 10)	NC score	0.873308 (rank : 10)
Query Neighborhood Hits	13	Target Neighborhood Hits	15	Shared Neighborhood Hits	10
SwissProt Accessions	O55028	Gene names	Bckdk
Domain Architecture
Description	[3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial precursor (EC 2.7.11.4) (Branched-chain alpha-ketoacid dehydrogenase kinase) (BCKDHKIN) (BCKD-kinase).

AL2SF_HUMAN
θ value	5.27518 (rank : 11)	NC score	0.050772 (rank : 11)
Query Neighborhood Hits	13	Target Neighborhood Hits	6	Shared Neighborhood Hits	5
SwissProt Accessions	Q6ZP36, Q8N8R4, Q96Q31	Gene names	ALS2CR16
Domain Architecture	No domain graphic available
Description	Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 16 protein.

ESPL1_MOUSE
θ value	6.88961 (rank : 12)	NC score	0.014537 (rank : 12)
Query Neighborhood Hits	13	Target Neighborhood Hits	67	Shared Neighborhood Hits	3
SwissProt Accessions	P60330	Gene names	Espl1, Esp1, Kiaa0165
Domain Architecture
Description	Separin (EC 3.4.22.49) (Separase) (Caspase-like protein ESPL1) (Extra spindle poles-like 1 protein).

TSH1_HUMAN
θ value	8.99809 (rank : 13)	NC score	0.005958 (rank : 13)
Query Neighborhood Hits	13	Target Neighborhood Hits	558	Shared Neighborhood Hits	3
SwissProt Accessions	Q6ZSZ6, O60534, Q4LE29, Q53EU4	Gene names	TSHZ1, SDCCAG33, TSH1
Domain Architecture	No domain graphic available
Description	Teashirt homolog 1 (Serologically defined colon cancer antigen 3) (Antigen NY-CO-33).

Hits sorted by NC score

PDK2_HUMAN
NC score	0.999962 (rank : 1)	θ value	0 (rank : 1)
Query Neighborhood Hits	13	Target Neighborhood Hits	13	Shared Neighborhood Hits	13
SwissProt Accessions	Q15119, Q9BS05	Gene names	PDK2
Domain Architecture
Description	[Pyruvate dehydrogenase [lipoamide]] kinase isozyme 2, mitochondrial precursor (EC 2.7.11.2) (Pyruvate dehydrogenase kinase isoform 2).

PDK2_MOUSE
NC score	0.999917 (rank : 2)	θ value	0 (rank : 2)
Query Neighborhood Hits	13	Target Neighborhood Hits	14	Shared Neighborhood Hits	13
SwissProt Accessions	Q9JK42	Gene names	Pdk2
Domain Architecture
Description	[Pyruvate dehydrogenase [lipoamide]] kinase isozyme 2, mitochondrial precursor (EC 2.7.11.2) (Pyruvate dehydrogenase kinase isoform 2).

PDK1_HUMAN
NC score	0.997570 (rank : 3)	θ value	1.6163e-166 (rank : 4)
Query Neighborhood Hits	13	Target Neighborhood Hits	13	Shared Neighborhood Hits	11
SwissProt Accessions	Q15118	Gene names	PDK1
Domain Architecture
Description	[Pyruvate dehydrogenase [lipoamide]] kinase isozyme 1, mitochondrial precursor (EC 2.7.11.2) (Pyruvate dehydrogenase kinase isoform 1).

PDK1_MOUSE
NC score	0.997236 (rank : 4)	θ value	5.55514e-167 (rank : 3)
Query Neighborhood Hits	13	Target Neighborhood Hits	14	Shared Neighborhood Hits	11
SwissProt Accessions	Q8BFP9	Gene names	Pdk1
Domain Architecture	No domain graphic available
Description	[Pyruvate dehydrogenase [lipoamide]] kinase isozyme 1, mitochondrial precursor (EC 2.7.11.2) (Pyruvate dehydrogenase kinase isoform 1).

PDK4_HUMAN
NC score	0.996612 (rank : 5)	θ value	8.88953e-157 (rank : 8)
Query Neighborhood Hits	13	Target Neighborhood Hits	11	Shared Neighborhood Hits	10
SwissProt Accessions	Q16654	Gene names	PDK4
Domain Architecture
Description	[Pyruvate dehydrogenase [lipoamide]] kinase isozyme 4, mitochondrial precursor (EC 2.7.11.2) (Pyruvate dehydrogenase kinase isoform 4).

PDK3_MOUSE
NC score	0.996611 (rank : 6)	θ value	8.30107e-163 (rank : 5)
Query Neighborhood Hits	13	Target Neighborhood Hits	17	Shared Neighborhood Hits	10
SwissProt Accessions	Q922H2, Q8BTX1	Gene names	Pdk3
Domain Architecture	No domain graphic available
Description	[Pyruvate dehydrogenase [lipoamide]] kinase isozyme 3, mitochondrial precursor (EC 2.7.11.2) (Pyruvate dehydrogenase kinase isoform 3).

PDK3_HUMAN
NC score	0.996539 (rank : 7)	θ value	6.57732e-160 (rank : 6)
Query Neighborhood Hits	13	Target Neighborhood Hits	17	Shared Neighborhood Hits	10
SwissProt Accessions	Q15120	Gene names	PDK3
Domain Architecture
Description	[Pyruvate dehydrogenase [lipoamide]] kinase isozyme 3, mitochondrial precursor (EC 2.7.11.2) (Pyruvate dehydrogenase kinase isoform 3).

PDK4_MOUSE
NC score	0.996507 (rank : 8)	θ value	2.76339e-158 (rank : 7)
Query Neighborhood Hits	13	Target Neighborhood Hits	18	Shared Neighborhood Hits	10
SwissProt Accessions	O70571	Gene names	Pdk4
Domain Architecture
Description	[Pyruvate dehydrogenase [lipoamide]] kinase isozyme 4, mitochondrial precursor (EC 2.7.11.2) (Pyruvate dehydrogenase kinase isoform 4).

BCKD_HUMAN
NC score	0.874233 (rank : 9)	θ value	2.26708e-35 (rank : 9)
Query Neighborhood Hits	13	Target Neighborhood Hits	15	Shared Neighborhood Hits	10
SwissProt Accessions	O14874, Q96IN5	Gene names	BCKDK
Domain Architecture
Description	[3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial precursor (EC 2.7.11.4) (Branched-chain alpha-ketoacid dehydrogenase kinase) (BCKDHKIN) (BCKD-kinase).

BCKD_MOUSE
NC score	0.873308 (rank : 10)	θ value	5.0505e-35 (rank : 10)
Query Neighborhood Hits	13	Target Neighborhood Hits	15	Shared Neighborhood Hits	10
SwissProt Accessions	O55028	Gene names	Bckdk
Domain Architecture
Description	[3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial precursor (EC 2.7.11.4) (Branched-chain alpha-ketoacid dehydrogenase kinase) (BCKDHKIN) (BCKD-kinase).

AL2SF_HUMAN
NC score	0.050772 (rank : 11)	θ value	5.27518 (rank : 11)
Query Neighborhood Hits	13	Target Neighborhood Hits	6	Shared Neighborhood Hits	5
SwissProt Accessions	Q6ZP36, Q8N8R4, Q96Q31	Gene names	ALS2CR16
Domain Architecture	No domain graphic available
Description	Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 16 protein.

ESPL1_MOUSE
NC score	0.014537 (rank : 12)	θ value	6.88961 (rank : 12)
Query Neighborhood Hits	13	Target Neighborhood Hits	67	Shared Neighborhood Hits	3
SwissProt Accessions	P60330	Gene names	Espl1, Esp1, Kiaa0165
Domain Architecture
Description	Separin (EC 3.4.22.49) (Separase) (Caspase-like protein ESPL1) (Extra spindle poles-like 1 protein).

TSH1_HUMAN
NC score	0.005958 (rank : 13)	θ value	8.99809 (rank : 13)
Query Neighborhood Hits	13	Target Neighborhood Hits	558	Shared Neighborhood Hits	3
SwissProt Accessions	Q6ZSZ6, O60534, Q4LE29, Q53EU4	Gene names	TSHZ1, SDCCAG33, TSH1
Domain Architecture	No domain graphic available
Description	Teashirt homolog 1 (Serologically defined colon cancer antigen 3) (Antigen NY-CO-33).