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Network neighborhood for query Sequence : OSTP_HUMAN

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OSTP_HUMAN
SwissProt Accessions	P10451, Q15681, Q15682, Q15683, Q8NBK2, Q96IZ1	Gene names	SPP1, OPN
Domain Architecture
Description	Osteopontin precursor (Bone sialoprotein-1) (Secreted phosphoprotein 1) (SPP-1) (Urinary stone protein) (Nephropontin) (Uropontin).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

OSTP_HUMAN
θ value	1.02182e-136 (rank : 1)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	36	Target Neighborhood Hits	36	Shared Neighborhood Hits	36
SwissProt Accessions	P10451, Q15681, Q15682, Q15683, Q8NBK2, Q96IZ1	Gene names	SPP1, OPN
Domain Architecture
Description	Osteopontin precursor (Bone sialoprotein-1) (Secreted phosphoprotein 1) (SPP-1) (Urinary stone protein) (Nephropontin) (Uropontin).

OSTP_MOUSE
θ value	7.19216e-82 (rank : 2)	NC score	0.937910 (rank : 2)
Query Neighborhood Hits	36	Target Neighborhood Hits	60	Shared Neighborhood Hits	13
SwissProt Accessions	P10923, P19008	Gene names	Spp1, Eta-1, Op, Spp-1
Domain Architecture
Description	Osteopontin precursor (Bone sialoprotein-1) (Secreted phosphoprotein 1) (SPP-1) (Minopontin) (Early T-lymphocyte activation 1 protein) (2AR) (Calcium oxalate crystal growth inhibitor protein).

CDON_MOUSE
θ value	0.0563607 (rank : 3)	NC score	0.031499 (rank : 28)
Query Neighborhood Hits	36	Target Neighborhood Hits	410	Shared Neighborhood Hits	3
SwissProt Accessions	Q32MD9, O88971	Gene names	Cdon, Cdo
Domain Architecture	No domain graphic available
Description	Cell adhesion molecule-related/down-regulated by oncogenes precursor.

TXND2_MOUSE
θ value	0.0736092 (rank : 4)	NC score	0.072778 (rank : 13)
Query Neighborhood Hits	36	Target Neighborhood Hits	828	Shared Neighborhood Hits	16
SwissProt Accessions	Q6P902, Q8CJD1	Gene names	Txndc2, Sptrx, Sptrx1, Trx4
Domain Architecture	No domain graphic available
Description	Thioredoxin domain-containing protein 2 (Spermatid-specific thioredoxin-1) (Sptrx-1) (Thioredoxin-4).

IWS1_MOUSE
θ value	0.0961366 (rank : 5)	NC score	0.093626 (rank : 9)
Query Neighborhood Hits	36	Target Neighborhood Hits	1258	Shared Neighborhood Hits	28
SwissProt Accessions	Q8C1D8, Q3TQ25, Q3UWB0, Q6NVD1, Q8BY73, Q9D9H4	Gene names	Iws1, Iws1l
Domain Architecture	No domain graphic available
Description	IWS1 homolog (IWS1-like protein).

LEO1_HUMAN
θ value	0.125558 (rank : 6)	NC score	0.100400 (rank : 7)
Query Neighborhood Hits	36	Target Neighborhood Hits	958	Shared Neighborhood Hits	23
SwissProt Accessions	Q8WVC0, Q96N99	Gene names	LEO1, RDL
Domain Architecture	No domain graphic available
Description	RNA polymerase-associated protein LEO1 (Replicative senescence down- regulated leo1-like protein).

IWS1_HUMAN
θ value	0.21417 (rank : 7)	NC score	0.101496 (rank : 6)
Query Neighborhood Hits	36	Target Neighborhood Hits	1241	Shared Neighborhood Hits	23
SwissProt Accessions	Q96ST2, Q6P157, Q8N3E8, Q96MI7, Q9NV97, Q9NWH8	Gene names	IWS1, IWS1L
Domain Architecture	No domain graphic available
Description	IWS1 homolog (IWS1-like protein).

VPS72_HUMAN
θ value	0.62314 (rank : 8)	NC score	0.121644 (rank : 4)
Query Neighborhood Hits	36	Target Neighborhood Hits	274	Shared Neighborhood Hits	11
SwissProt Accessions	Q15906, Q53GJ2, Q5U0R4	Gene names	VPS72, TCFL1, YL1
Domain Architecture
Description	Vacuolar protein sorting-associated protein 72 homolog (Transcription factor-like 1) (Protein YL-1).

VPS72_MOUSE
θ value	0.62314 (rank : 9)	NC score	0.122325 (rank : 3)
Query Neighborhood Hits	36	Target Neighborhood Hits	286	Shared Neighborhood Hits	12
SwissProt Accessions	Q62481, Q3U2N4, Q810A9, Q99K81	Gene names	Vps72, Tcfl1, Yl1
Domain Architecture
Description	Vacuolar protein sorting-associated protein 72 homolog (Transcription factor-like 1) (Protein YL-1).

LEO1_MOUSE
θ value	1.06291 (rank : 10)	NC score	0.096890 (rank : 8)
Query Neighborhood Hits	36	Target Neighborhood Hits	946	Shared Neighborhood Hits	24
SwissProt Accessions	Q5XJE5, Q640R1	Gene names	Leo1
Domain Architecture	No domain graphic available
Description	RNA polymerase-associated protein LEO1.

CASC5_HUMAN
θ value	1.81305 (rank : 11)	NC score	0.038102 (rank : 23)
Query Neighborhood Hits	36	Target Neighborhood Hits	376	Shared Neighborhood Hits	4
SwissProt Accessions	Q8NG31, Q8NHE1, Q8WXA6, Q9HCK2, Q9NR92	Gene names	CASC5, KIAA1570
Domain Architecture	No domain graphic available
Description	Protein CASC5 (Cancer susceptibility candidate gene 5 protein) (ALL1- fused gene from chromosome 15q14) (AF15q14) (D40/AF15q14 protein).

EF2K_MOUSE
θ value	1.81305 (rank : 12)	NC score	0.044455 (rank : 20)
Query Neighborhood Hits	36	Target Neighborhood Hits	33	Shared Neighborhood Hits	6
SwissProt Accessions	O08796	Gene names	Eef2k
Domain Architecture
Description	Elongation factor 2 kinase (EC 2.7.11.20) (eEF-2 kinase) (eEF-2K) (Calcium/calmodulin-dependent eukaryotic elongation factor 2 kinase).

LRP2_HUMAN
θ value	1.81305 (rank : 13)	NC score	0.013292 (rank : 41)
Query Neighborhood Hits	36	Target Neighborhood Hits	573	Shared Neighborhood Hits	3
SwissProt Accessions	P98164, O00711, Q16215	Gene names	LRP2
Domain Architecture
Description	Low-density lipoprotein receptor-related protein 2 precursor (Megalin) (Glycoprotein 330) (gp330).

NIPBL_HUMAN
θ value	2.36792 (rank : 14)	NC score	0.037519 (rank : 24)
Query Neighborhood Hits	36	Target Neighborhood Hits	1311	Shared Neighborhood Hits	17
SwissProt Accessions	Q6KC79, Q6KCD6, Q6N080, Q6ZT92, Q7Z2E6, Q8N4M5, Q9Y6Y3, Q9Y6Y4	Gene names	NIPBL, IDN3
Domain Architecture	No domain graphic available
Description	Nipped-B-like protein (Delangin) (SCC2 homolog).

ROCK1_MOUSE
θ value	2.36792 (rank : 15)	NC score	0.005894 (rank : 42)
Query Neighborhood Hits	36	Target Neighborhood Hits	2126	Shared Neighborhood Hits	10
SwissProt Accessions	P70335, Q8C3G4, Q8C7H0	Gene names	Rock1
Domain Architecture
Description	Rho-associated protein kinase 1 (EC 2.7.11.1) (Rho-associated, coiled- coil-containing protein kinase 1) (p160 ROCK-1) (p160ROCK).

CEND1_MOUSE
θ value	3.0926 (rank : 16)	NC score	0.017459 (rank : 38)
Query Neighborhood Hits	36	Target Neighborhood Hits	260	Shared Neighborhood Hits	4
SwissProt Accessions	Q8BZ05, Q80TX2, Q8C3T2, Q8VEL6	Gene names	Centd1, Kiaa0580
Domain Architecture	No domain graphic available
Description	Centaurin-delta 1 (Cnt-d1).

WFD12_HUMAN
θ value	3.0926 (rank : 17)	NC score	0.045987 (rank : 19)
Query Neighborhood Hits	36	Target Neighborhood Hits	22	Shared Neighborhood Hits	2
SwissProt Accessions	Q8WWY7, Q5H980, Q9BR31	Gene names	WFDC12, C20orf122, WAP2
Domain Architecture
Description	WAP four-disulfide core domain protein 12 precursor (Putative protease inhibitor WAP12) (Whey acidic protein 2).

CALX_MOUSE
θ value	4.03905 (rank : 18)	NC score	0.035018 (rank : 25)
Query Neighborhood Hits	36	Target Neighborhood Hits	76	Shared Neighborhood Hits	8
SwissProt Accessions	P35564	Gene names	Canx
Domain Architecture
Description	Calnexin precursor.

DSPP_HUMAN
θ value	4.03905 (rank : 19)	NC score	0.088820 (rank : 10)
Query Neighborhood Hits	36	Target Neighborhood Hits	645	Shared Neighborhood Hits	19
SwissProt Accessions	Q9NZW4, O95815	Gene names	DSPP
Domain Architecture	No domain graphic available
Description	Dentin sialophosphoprotein precursor [Contains: Dentin phosphoprotein (Dentin phosphophoryn) (DPP); Dentin sialoprotein (DSP)].

PCLO_HUMAN
θ value	4.03905 (rank : 20)	NC score	0.022501 (rank : 36)
Query Neighborhood Hits	36	Target Neighborhood Hits	2046	Shared Neighborhood Hits	14
SwissProt Accessions	Q9Y6V0, O43373, O60305, Q9BVC8, Q9UIV2, Q9Y6U9	Gene names	PCLO, ACZ, KIAA0559
Domain Architecture
Description	Protein piccolo (Aczonin).

RNUXA_MOUSE
θ value	4.03905 (rank : 21)	NC score	0.033752 (rank : 26)
Query Neighborhood Hits	36	Target Neighborhood Hits	22	Shared Neighborhood Hits	2
SwissProt Accessions	Q9JJT9, Q8BSR8	Gene names	Rnuxa, Phax
Domain Architecture	No domain graphic available
Description	RNA U small nuclear RNA export adapter protein (Phosphorylated adapter RNA export protein).

ALMS1_MOUSE
θ value	5.27518 (rank : 22)	NC score	0.038791 (rank : 22)
Query Neighborhood Hits	36	Target Neighborhood Hits	181	Shared Neighborhood Hits	7
SwissProt Accessions	Q8K4E0, Q6A084, Q8C9N9	Gene names	Alms1, Kiaa0328
Domain Architecture	No domain graphic available
Description	Alstrom syndrome protein 1 homolog.

C8AP2_HUMAN
θ value	5.27518 (rank : 23)	NC score	0.031260 (rank : 29)
Query Neighborhood Hits	36	Target Neighborhood Hits	548	Shared Neighborhood Hits	13
SwissProt Accessions	Q9UKL3, Q6PH76, Q7LCQ7, Q86YD9, Q9NUQ4, Q9NZV9, Q9P2N1, Q9Y563	Gene names	CASP8AP2, FLASH, KIAA1315, RIP25
Domain Architecture	No domain graphic available
Description	CASP8-associated protein 2 (FLICE-associated huge protein).

CC47_MOUSE
θ value	5.27518 (rank : 24)	NC score	0.031033 (rank : 30)
Query Neighborhood Hits	36	Target Neighborhood Hits	245	Shared Neighborhood Hits	11
SwissProt Accessions	Q9D024, Q3TSB5, Q3V1S7, Q8C5D9, Q920S6	Gene names	Ccdc47, Asp4
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 47 precursor (Adipocyte-specific protein 4).

DMP1_HUMAN
θ value	5.27518 (rank : 25)	NC score	0.101801 (rank : 5)
Query Neighborhood Hits	36	Target Neighborhood Hits	491	Shared Neighborhood Hits	16
SwissProt Accessions	Q13316, O43265	Gene names	DMP1
Domain Architecture
Description	Dentin matrix acidic phosphoprotein 1 precursor (Dentin matrix protein 1) (DMP-1).

ROCK1_HUMAN
θ value	5.27518 (rank : 26)	NC score	0.005481 (rank : 43)
Query Neighborhood Hits	36	Target Neighborhood Hits	2000	Shared Neighborhood Hits	10
SwissProt Accessions	Q13464	Gene names	ROCK1
Domain Architecture
Description	Rho-associated protein kinase 1 (EC 2.7.11.1) (Rho-associated, coiled- coil-containing protein kinase 1) (p160 ROCK-1) (p160ROCK) (NY-REN-35 antigen).

STA13_MOUSE
θ value	5.27518 (rank : 27)	NC score	0.020269 (rank : 37)
Query Neighborhood Hits	36	Target Neighborhood Hits	89	Shared Neighborhood Hits	5
SwissProt Accessions	Q923Q2, Q8K369	Gene names	Stard13
Domain Architecture
Description	StAR-related lipid transfer protein 13 (StARD13) (START domain- containing protein 13).

SV2C_HUMAN
θ value	5.27518 (rank : 28)	NC score	0.016125 (rank : 39)
Query Neighborhood Hits	36	Target Neighborhood Hits	124	Shared Neighborhood Hits	6
SwissProt Accessions	Q496J9, Q496K1, Q9UPU8	Gene names	SV2C, KIAA1054
Domain Architecture	No domain graphic available
Description	Synaptic vesicle glycoprotein 2C.

ALMS1_HUMAN
θ value	6.88961 (rank : 29)	NC score	0.039660 (rank : 21)
Query Neighborhood Hits	36	Target Neighborhood Hits	356	Shared Neighborhood Hits	6
SwissProt Accessions	Q8TCU4, Q53S05, Q580Q8, Q86VP9, Q9Y4G4	Gene names	ALMS1, KIAA0328
Domain Architecture	No domain graphic available
Description	Alstrom syndrome protein 1.

CALR_HUMAN
θ value	6.88961 (rank : 30)	NC score	0.030409 (rank : 31)
Query Neighborhood Hits	36	Target Neighborhood Hits	85	Shared Neighborhood Hits	10
SwissProt Accessions	P27797	Gene names	CALR, CRTC
Domain Architecture
Description	Calreticulin precursor (CRP55) (Calregulin) (HACBP) (ERp60) (grp60).

RPGR_HUMAN
θ value	6.88961 (rank : 31)	NC score	0.023771 (rank : 35)
Query Neighborhood Hits	36	Target Neighborhood Hits	279	Shared Neighborhood Hits	11
SwissProt Accessions	Q92834, O00702, O00737, Q8N5T6, Q93039, Q9HD29, Q9UMR1	Gene names	RPGR, RP3, XLRP3
Domain Architecture
Description	X-linked retinitis pigmentosa GTPase regulator.

SRCA_MOUSE
θ value	6.88961 (rank : 32)	NC score	0.025993 (rank : 34)
Query Neighborhood Hits	36	Target Neighborhood Hits	212	Shared Neighborhood Hits	10
SwissProt Accessions	Q7TQ48, Q8BS43	Gene names	Srl, Sar
Domain Architecture	No domain graphic available
Description	Sarcalumenin precursor.

FILA_HUMAN
θ value	8.99809 (rank : 33)	NC score	0.033000 (rank : 27)
Query Neighborhood Hits	36	Target Neighborhood Hits	685	Shared Neighborhood Hits	14
SwissProt Accessions	P20930, Q01720, Q5T583	Gene names	FLG
Domain Architecture	No domain graphic available
Description	Filaggrin.

PDZD8_HUMAN
θ value	8.99809 (rank : 34)	NC score	0.028207 (rank : 32)
Query Neighborhood Hits	36	Target Neighborhood Hits	185	Shared Neighborhood Hits	5
SwissProt Accessions	Q8NEN9, Q86WE0, Q86WE5, Q9UFF1	Gene names	PDZD8, PDZK8
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 8 (Sarcoma antigen NY-SAR-84/NY-SAR- 104).

SETD2_HUMAN
θ value	8.99809 (rank : 35)	NC score	0.027151 (rank : 33)
Query Neighborhood Hits	36	Target Neighborhood Hits	412	Shared Neighborhood Hits	13
SwissProt Accessions	Q9BYW2, O75397, O75405, Q17RW8, Q5BKS9, Q5QGN2, Q69YI5, Q6IN64, Q6ZN53, Q6ZS25, Q8N3R0, Q8TCN0, Q9C0D1, Q9H696, Q9NZW9	Gene names	SETD2, HIF1, HYPB, KIAA1732, SET2
Domain Architecture	No domain graphic available
Description	Histone-lysine N-methyltransferase, H3 lysine-36-specific (EC 2.1.1.43) (SET domain-containing protein 2) (hSET2) (Huntingtin- interacting protein HYPB) (Huntingtin-interacting protein 1) (HIF-1) (p231HBP).

WRN_MOUSE
θ value	8.99809 (rank : 36)	NC score	0.014935 (rank : 40)
Query Neighborhood Hits	36	Target Neighborhood Hits	295	Shared Neighborhood Hits	11
SwissProt Accessions	O09053, O09050, Q9JKD4, Q9Z241, Q9Z242	Gene names	Wrn
Domain Architecture
Description	Werner syndrome ATP-dependent helicase homolog (EC 3.6.1.-).

CYLC2_HUMAN
θ value	θ > 10 (rank : 37)	NC score	0.050841 (rank : 18)
Query Neighborhood Hits	36	Target Neighborhood Hits	223	Shared Neighborhood Hits	12
SwissProt Accessions	Q14093	Gene names	CYLC2, CYL2
Domain Architecture	No domain graphic available
Description	Cylicin-2 (Cylicin II) (Multiple-band polypeptide II).

DMP1_MOUSE
θ value	θ > 10 (rank : 38)	NC score	0.074869 (rank : 12)
Query Neighborhood Hits	36	Target Neighborhood Hits	498	Shared Neighborhood Hits	17
SwissProt Accessions	O55188	Gene names	Dmp1, Dmp
Domain Architecture
Description	Dentin matrix acidic phosphoprotein 1 precursor (Dentin matrix protein 1) (DMP-1) (AG1).

DSPP_MOUSE
θ value	θ > 10 (rank : 39)	NC score	0.085179 (rank : 11)
Query Neighborhood Hits	36	Target Neighborhood Hits	491	Shared Neighborhood Hits	15
SwissProt Accessions	P97399, O70567	Gene names	Dspp
Domain Architecture	No domain graphic available
Description	Dentin sialophosphoprotein precursor (Dentin matrix protein 3) (DMP-3) [Contains: Dentin phosphoprotein (Dentin phosphophoryn) (DPP); Dentin sialoprotein (DSP)].

NUCKS_HUMAN
θ value	θ > 10 (rank : 40)	NC score	0.059429 (rank : 15)
Query Neighborhood Hits	36	Target Neighborhood Hits	143	Shared Neighborhood Hits	8
SwissProt Accessions	Q9H1E3, Q9H1D6, Q9H723	Gene names	NUCKS1, NUCKS
Domain Architecture	No domain graphic available
Description	Nuclear ubiquitous casein and cyclin-dependent kinases substrate (P1).

NUCKS_MOUSE
θ value	θ > 10 (rank : 41)	NC score	0.062065 (rank : 14)
Query Neighborhood Hits	36	Target Neighborhood Hits	114	Shared Neighborhood Hits	9
SwissProt Accessions	Q80XU3, Q8BVD8	Gene names	Nucks1, Nucks
Domain Architecture	No domain graphic available
Description	Nuclear ubiquitous casein and cyclin-dependent kinases substrate (JC7).

PTMA_HUMAN
θ value	θ > 10 (rank : 42)	NC score	0.051711 (rank : 17)
Query Neighborhood Hits	36	Target Neighborhood Hits	88	Shared Neighborhood Hits	7
SwissProt Accessions	P06454, Q15249, Q15592	Gene names	PTMA, TMSA
Domain Architecture	No domain graphic available
Description	Prothymosin alpha [Contains: Thymosin alpha-1].

PTMA_MOUSE
θ value	θ > 10 (rank : 43)	NC score	0.052384 (rank : 16)
Query Neighborhood Hits	36	Target Neighborhood Hits	73	Shared Neighborhood Hits	6
SwissProt Accessions	P26350, Q3UQV6	Gene names	Ptma
Domain Architecture	No domain graphic available
Description	Prothymosin alpha [Contains: Thymosin alpha].

Hits sorted by NC score

OSTP_HUMAN
NC score	0.999962 (rank : 1)	θ value	1.02182e-136 (rank : 1)
Query Neighborhood Hits	36	Target Neighborhood Hits	36	Shared Neighborhood Hits	36
SwissProt Accessions	P10451, Q15681, Q15682, Q15683, Q8NBK2, Q96IZ1	Gene names	SPP1, OPN
Domain Architecture
Description	Osteopontin precursor (Bone sialoprotein-1) (Secreted phosphoprotein 1) (SPP-1) (Urinary stone protein) (Nephropontin) (Uropontin).

OSTP_MOUSE
NC score	0.937910 (rank : 2)	θ value	7.19216e-82 (rank : 2)
Query Neighborhood Hits	36	Target Neighborhood Hits	60	Shared Neighborhood Hits	13
SwissProt Accessions	P10923, P19008	Gene names	Spp1, Eta-1, Op, Spp-1
Domain Architecture
Description	Osteopontin precursor (Bone sialoprotein-1) (Secreted phosphoprotein 1) (SPP-1) (Minopontin) (Early T-lymphocyte activation 1 protein) (2AR) (Calcium oxalate crystal growth inhibitor protein).

VPS72_MOUSE
NC score	0.122325 (rank : 3)	θ value	0.62314 (rank : 9)
Query Neighborhood Hits	36	Target Neighborhood Hits	286	Shared Neighborhood Hits	12
SwissProt Accessions	Q62481, Q3U2N4, Q810A9, Q99K81	Gene names	Vps72, Tcfl1, Yl1
Domain Architecture
Description	Vacuolar protein sorting-associated protein 72 homolog (Transcription factor-like 1) (Protein YL-1).

VPS72_HUMAN
NC score	0.121644 (rank : 4)	θ value	0.62314 (rank : 8)
Query Neighborhood Hits	36	Target Neighborhood Hits	274	Shared Neighborhood Hits	11
SwissProt Accessions	Q15906, Q53GJ2, Q5U0R4	Gene names	VPS72, TCFL1, YL1
Domain Architecture
Description	Vacuolar protein sorting-associated protein 72 homolog (Transcription factor-like 1) (Protein YL-1).

DMP1_HUMAN
NC score	0.101801 (rank : 5)	θ value	5.27518 (rank : 25)
Query Neighborhood Hits	36	Target Neighborhood Hits	491	Shared Neighborhood Hits	16
SwissProt Accessions	Q13316, O43265	Gene names	DMP1
Domain Architecture
Description	Dentin matrix acidic phosphoprotein 1 precursor (Dentin matrix protein 1) (DMP-1).

IWS1_HUMAN
NC score	0.101496 (rank : 6)	θ value	0.21417 (rank : 7)
Query Neighborhood Hits	36	Target Neighborhood Hits	1241	Shared Neighborhood Hits	23
SwissProt Accessions	Q96ST2, Q6P157, Q8N3E8, Q96MI7, Q9NV97, Q9NWH8	Gene names	IWS1, IWS1L
Domain Architecture	No domain graphic available
Description	IWS1 homolog (IWS1-like protein).

LEO1_HUMAN
NC score	0.100400 (rank : 7)	θ value	0.125558 (rank : 6)
Query Neighborhood Hits	36	Target Neighborhood Hits	958	Shared Neighborhood Hits	23
SwissProt Accessions	Q8WVC0, Q96N99	Gene names	LEO1, RDL
Domain Architecture	No domain graphic available
Description	RNA polymerase-associated protein LEO1 (Replicative senescence down- regulated leo1-like protein).

LEO1_MOUSE
NC score	0.096890 (rank : 8)	θ value	1.06291 (rank : 10)
Query Neighborhood Hits	36	Target Neighborhood Hits	946	Shared Neighborhood Hits	24
SwissProt Accessions	Q5XJE5, Q640R1	Gene names	Leo1
Domain Architecture	No domain graphic available
Description	RNA polymerase-associated protein LEO1.

IWS1_MOUSE
NC score	0.093626 (rank : 9)	θ value	0.0961366 (rank : 5)
Query Neighborhood Hits	36	Target Neighborhood Hits	1258	Shared Neighborhood Hits	28
SwissProt Accessions	Q8C1D8, Q3TQ25, Q3UWB0, Q6NVD1, Q8BY73, Q9D9H4	Gene names	Iws1, Iws1l
Domain Architecture	No domain graphic available
Description	IWS1 homolog (IWS1-like protein).

DSPP_HUMAN
NC score	0.088820 (rank : 10)	θ value	4.03905 (rank : 19)
Query Neighborhood Hits	36	Target Neighborhood Hits	645	Shared Neighborhood Hits	19
SwissProt Accessions	Q9NZW4, O95815	Gene names	DSPP
Domain Architecture	No domain graphic available
Description	Dentin sialophosphoprotein precursor [Contains: Dentin phosphoprotein (Dentin phosphophoryn) (DPP); Dentin sialoprotein (DSP)].

DSPP_MOUSE
NC score	0.085179 (rank : 11)	θ value	θ > 10 (rank : 39)
Query Neighborhood Hits	36	Target Neighborhood Hits	491	Shared Neighborhood Hits	15
SwissProt Accessions	P97399, O70567	Gene names	Dspp
Domain Architecture	No domain graphic available
Description	Dentin sialophosphoprotein precursor (Dentin matrix protein 3) (DMP-3) [Contains: Dentin phosphoprotein (Dentin phosphophoryn) (DPP); Dentin sialoprotein (DSP)].

DMP1_MOUSE
NC score	0.074869 (rank : 12)	θ value	θ > 10 (rank : 38)
Query Neighborhood Hits	36	Target Neighborhood Hits	498	Shared Neighborhood Hits	17
SwissProt Accessions	O55188	Gene names	Dmp1, Dmp
Domain Architecture
Description	Dentin matrix acidic phosphoprotein 1 precursor (Dentin matrix protein 1) (DMP-1) (AG1).

TXND2_MOUSE
NC score	0.072778 (rank : 13)	θ value	0.0736092 (rank : 4)
Query Neighborhood Hits	36	Target Neighborhood Hits	828	Shared Neighborhood Hits	16
SwissProt Accessions	Q6P902, Q8CJD1	Gene names	Txndc2, Sptrx, Sptrx1, Trx4
Domain Architecture	No domain graphic available
Description	Thioredoxin domain-containing protein 2 (Spermatid-specific thioredoxin-1) (Sptrx-1) (Thioredoxin-4).

NUCKS_MOUSE
NC score	0.062065 (rank : 14)	θ value	θ > 10 (rank : 41)
Query Neighborhood Hits	36	Target Neighborhood Hits	114	Shared Neighborhood Hits	9
SwissProt Accessions	Q80XU3, Q8BVD8	Gene names	Nucks1, Nucks
Domain Architecture	No domain graphic available
Description	Nuclear ubiquitous casein and cyclin-dependent kinases substrate (JC7).

NUCKS_HUMAN
NC score	0.059429 (rank : 15)	θ value	θ > 10 (rank : 40)
Query Neighborhood Hits	36	Target Neighborhood Hits	143	Shared Neighborhood Hits	8
SwissProt Accessions	Q9H1E3, Q9H1D6, Q9H723	Gene names	NUCKS1, NUCKS
Domain Architecture	No domain graphic available
Description	Nuclear ubiquitous casein and cyclin-dependent kinases substrate (P1).

PTMA_MOUSE
NC score	0.052384 (rank : 16)	θ value	θ > 10 (rank : 43)
Query Neighborhood Hits	36	Target Neighborhood Hits	73	Shared Neighborhood Hits	6
SwissProt Accessions	P26350, Q3UQV6	Gene names	Ptma
Domain Architecture	No domain graphic available
Description	Prothymosin alpha [Contains: Thymosin alpha].

PTMA_HUMAN
NC score	0.051711 (rank : 17)	θ value	θ > 10 (rank : 42)
Query Neighborhood Hits	36	Target Neighborhood Hits	88	Shared Neighborhood Hits	7
SwissProt Accessions	P06454, Q15249, Q15592	Gene names	PTMA, TMSA
Domain Architecture	No domain graphic available
Description	Prothymosin alpha [Contains: Thymosin alpha-1].

CYLC2_HUMAN
NC score	0.050841 (rank : 18)	θ value	θ > 10 (rank : 37)
Query Neighborhood Hits	36	Target Neighborhood Hits	223	Shared Neighborhood Hits	12
SwissProt Accessions	Q14093	Gene names	CYLC2, CYL2
Domain Architecture	No domain graphic available
Description	Cylicin-2 (Cylicin II) (Multiple-band polypeptide II).

WFD12_HUMAN
NC score	0.045987 (rank : 19)	θ value	3.0926 (rank : 17)
Query Neighborhood Hits	36	Target Neighborhood Hits	22	Shared Neighborhood Hits	2
SwissProt Accessions	Q8WWY7, Q5H980, Q9BR31	Gene names	WFDC12, C20orf122, WAP2
Domain Architecture
Description	WAP four-disulfide core domain protein 12 precursor (Putative protease inhibitor WAP12) (Whey acidic protein 2).

EF2K_MOUSE
NC score	0.044455 (rank : 20)	θ value	1.81305 (rank : 12)
Query Neighborhood Hits	36	Target Neighborhood Hits	33	Shared Neighborhood Hits	6
SwissProt Accessions	O08796	Gene names	Eef2k
Domain Architecture
Description	Elongation factor 2 kinase (EC 2.7.11.20) (eEF-2 kinase) (eEF-2K) (Calcium/calmodulin-dependent eukaryotic elongation factor 2 kinase).

ALMS1_HUMAN
NC score	0.039660 (rank : 21)	θ value	6.88961 (rank : 29)
Query Neighborhood Hits	36	Target Neighborhood Hits	356	Shared Neighborhood Hits	6
SwissProt Accessions	Q8TCU4, Q53S05, Q580Q8, Q86VP9, Q9Y4G4	Gene names	ALMS1, KIAA0328
Domain Architecture	No domain graphic available
Description	Alstrom syndrome protein 1.

ALMS1_MOUSE
NC score	0.038791 (rank : 22)	θ value	5.27518 (rank : 22)
Query Neighborhood Hits	36	Target Neighborhood Hits	181	Shared Neighborhood Hits	7
SwissProt Accessions	Q8K4E0, Q6A084, Q8C9N9	Gene names	Alms1, Kiaa0328
Domain Architecture	No domain graphic available
Description	Alstrom syndrome protein 1 homolog.

CASC5_HUMAN
NC score	0.038102 (rank : 23)	θ value	1.81305 (rank : 11)
Query Neighborhood Hits	36	Target Neighborhood Hits	376	Shared Neighborhood Hits	4
SwissProt Accessions	Q8NG31, Q8NHE1, Q8WXA6, Q9HCK2, Q9NR92	Gene names	CASC5, KIAA1570
Domain Architecture	No domain graphic available
Description	Protein CASC5 (Cancer susceptibility candidate gene 5 protein) (ALL1- fused gene from chromosome 15q14) (AF15q14) (D40/AF15q14 protein).

NIPBL_HUMAN
NC score	0.037519 (rank : 24)	θ value	2.36792 (rank : 14)
Query Neighborhood Hits	36	Target Neighborhood Hits	1311	Shared Neighborhood Hits	17
SwissProt Accessions	Q6KC79, Q6KCD6, Q6N080, Q6ZT92, Q7Z2E6, Q8N4M5, Q9Y6Y3, Q9Y6Y4	Gene names	NIPBL, IDN3
Domain Architecture	No domain graphic available
Description	Nipped-B-like protein (Delangin) (SCC2 homolog).

CALX_MOUSE
NC score	0.035018 (rank : 25)	θ value	4.03905 (rank : 18)
Query Neighborhood Hits	36	Target Neighborhood Hits	76	Shared Neighborhood Hits	8
SwissProt Accessions	P35564	Gene names	Canx
Domain Architecture
Description	Calnexin precursor.

RNUXA_MOUSE
NC score	0.033752 (rank : 26)	θ value	4.03905 (rank : 21)
Query Neighborhood Hits	36	Target Neighborhood Hits	22	Shared Neighborhood Hits	2
SwissProt Accessions	Q9JJT9, Q8BSR8	Gene names	Rnuxa, Phax
Domain Architecture	No domain graphic available
Description	RNA U small nuclear RNA export adapter protein (Phosphorylated adapter RNA export protein).

FILA_HUMAN
NC score	0.033000 (rank : 27)	θ value	8.99809 (rank : 33)
Query Neighborhood Hits	36	Target Neighborhood Hits	685	Shared Neighborhood Hits	14
SwissProt Accessions	P20930, Q01720, Q5T583	Gene names	FLG
Domain Architecture	No domain graphic available
Description	Filaggrin.

CDON_MOUSE
NC score	0.031499 (rank : 28)	θ value	0.0563607 (rank : 3)
Query Neighborhood Hits	36	Target Neighborhood Hits	410	Shared Neighborhood Hits	3
SwissProt Accessions	Q32MD9, O88971	Gene names	Cdon, Cdo
Domain Architecture	No domain graphic available
Description	Cell adhesion molecule-related/down-regulated by oncogenes precursor.

C8AP2_HUMAN
NC score	0.031260 (rank : 29)	θ value	5.27518 (rank : 23)
Query Neighborhood Hits	36	Target Neighborhood Hits	548	Shared Neighborhood Hits	13
SwissProt Accessions	Q9UKL3, Q6PH76, Q7LCQ7, Q86YD9, Q9NUQ4, Q9NZV9, Q9P2N1, Q9Y563	Gene names	CASP8AP2, FLASH, KIAA1315, RIP25
Domain Architecture	No domain graphic available
Description	CASP8-associated protein 2 (FLICE-associated huge protein).

CC47_MOUSE
NC score	0.031033 (rank : 30)	θ value	5.27518 (rank : 24)
Query Neighborhood Hits	36	Target Neighborhood Hits	245	Shared Neighborhood Hits	11
SwissProt Accessions	Q9D024, Q3TSB5, Q3V1S7, Q8C5D9, Q920S6	Gene names	Ccdc47, Asp4
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 47 precursor (Adipocyte-specific protein 4).

CALR_HUMAN
NC score	0.030409 (rank : 31)	θ value	6.88961 (rank : 30)
Query Neighborhood Hits	36	Target Neighborhood Hits	85	Shared Neighborhood Hits	10
SwissProt Accessions	P27797	Gene names	CALR, CRTC
Domain Architecture
Description	Calreticulin precursor (CRP55) (Calregulin) (HACBP) (ERp60) (grp60).

PDZD8_HUMAN
NC score	0.028207 (rank : 32)	θ value	8.99809 (rank : 34)
Query Neighborhood Hits	36	Target Neighborhood Hits	185	Shared Neighborhood Hits	5
SwissProt Accessions	Q8NEN9, Q86WE0, Q86WE5, Q9UFF1	Gene names	PDZD8, PDZK8
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 8 (Sarcoma antigen NY-SAR-84/NY-SAR- 104).

SETD2_HUMAN
NC score	0.027151 (rank : 33)	θ value	8.99809 (rank : 35)
Query Neighborhood Hits	36	Target Neighborhood Hits	412	Shared Neighborhood Hits	13
SwissProt Accessions	Q9BYW2, O75397, O75405, Q17RW8, Q5BKS9, Q5QGN2, Q69YI5, Q6IN64, Q6ZN53, Q6ZS25, Q8N3R0, Q8TCN0, Q9C0D1, Q9H696, Q9NZW9	Gene names	SETD2, HIF1, HYPB, KIAA1732, SET2
Domain Architecture	No domain graphic available
Description	Histone-lysine N-methyltransferase, H3 lysine-36-specific (EC 2.1.1.43) (SET domain-containing protein 2) (hSET2) (Huntingtin- interacting protein HYPB) (Huntingtin-interacting protein 1) (HIF-1) (p231HBP).

SRCA_MOUSE
NC score	0.025993 (rank : 34)	θ value	6.88961 (rank : 32)
Query Neighborhood Hits	36	Target Neighborhood Hits	212	Shared Neighborhood Hits	10
SwissProt Accessions	Q7TQ48, Q8BS43	Gene names	Srl, Sar
Domain Architecture	No domain graphic available
Description	Sarcalumenin precursor.

RPGR_HUMAN
NC score	0.023771 (rank : 35)	θ value	6.88961 (rank : 31)
Query Neighborhood Hits	36	Target Neighborhood Hits	279	Shared Neighborhood Hits	11
SwissProt Accessions	Q92834, O00702, O00737, Q8N5T6, Q93039, Q9HD29, Q9UMR1	Gene names	RPGR, RP3, XLRP3
Domain Architecture
Description	X-linked retinitis pigmentosa GTPase regulator.

PCLO_HUMAN
NC score	0.022501 (rank : 36)	θ value	4.03905 (rank : 20)
Query Neighborhood Hits	36	Target Neighborhood Hits	2046	Shared Neighborhood Hits	14
SwissProt Accessions	Q9Y6V0, O43373, O60305, Q9BVC8, Q9UIV2, Q9Y6U9	Gene names	PCLO, ACZ, KIAA0559
Domain Architecture
Description	Protein piccolo (Aczonin).

STA13_MOUSE
NC score	0.020269 (rank : 37)	θ value	5.27518 (rank : 27)
Query Neighborhood Hits	36	Target Neighborhood Hits	89	Shared Neighborhood Hits	5
SwissProt Accessions	Q923Q2, Q8K369	Gene names	Stard13
Domain Architecture
Description	StAR-related lipid transfer protein 13 (StARD13) (START domain- containing protein 13).

CEND1_MOUSE
NC score	0.017459 (rank : 38)	θ value	3.0926 (rank : 16)
Query Neighborhood Hits	36	Target Neighborhood Hits	260	Shared Neighborhood Hits	4
SwissProt Accessions	Q8BZ05, Q80TX2, Q8C3T2, Q8VEL6	Gene names	Centd1, Kiaa0580
Domain Architecture	No domain graphic available
Description	Centaurin-delta 1 (Cnt-d1).

SV2C_HUMAN
NC score	0.016125 (rank : 39)	θ value	5.27518 (rank : 28)
Query Neighborhood Hits	36	Target Neighborhood Hits	124	Shared Neighborhood Hits	6
SwissProt Accessions	Q496J9, Q496K1, Q9UPU8	Gene names	SV2C, KIAA1054
Domain Architecture	No domain graphic available
Description	Synaptic vesicle glycoprotein 2C.

WRN_MOUSE
NC score	0.014935 (rank : 40)	θ value	8.99809 (rank : 36)
Query Neighborhood Hits	36	Target Neighborhood Hits	295	Shared Neighborhood Hits	11
SwissProt Accessions	O09053, O09050, Q9JKD4, Q9Z241, Q9Z242	Gene names	Wrn
Domain Architecture
Description	Werner syndrome ATP-dependent helicase homolog (EC 3.6.1.-).

LRP2_HUMAN
NC score	0.013292 (rank : 41)	θ value	1.81305 (rank : 13)
Query Neighborhood Hits	36	Target Neighborhood Hits	573	Shared Neighborhood Hits	3
SwissProt Accessions	P98164, O00711, Q16215	Gene names	LRP2
Domain Architecture
Description	Low-density lipoprotein receptor-related protein 2 precursor (Megalin) (Glycoprotein 330) (gp330).

ROCK1_MOUSE
NC score	0.005894 (rank : 42)	θ value	2.36792 (rank : 15)
Query Neighborhood Hits	36	Target Neighborhood Hits	2126	Shared Neighborhood Hits	10
SwissProt Accessions	P70335, Q8C3G4, Q8C7H0	Gene names	Rock1
Domain Architecture
Description	Rho-associated protein kinase 1 (EC 2.7.11.1) (Rho-associated, coiled- coil-containing protein kinase 1) (p160 ROCK-1) (p160ROCK).

ROCK1_HUMAN
NC score	0.005481 (rank : 43)	θ value	5.27518 (rank : 26)
Query Neighborhood Hits	36	Target Neighborhood Hits	2000	Shared Neighborhood Hits	10
SwissProt Accessions	Q13464	Gene names	ROCK1
Domain Architecture
Description	Rho-associated protein kinase 1 (EC 2.7.11.1) (Rho-associated, coiled- coil-containing protein kinase 1) (p160 ROCK-1) (p160ROCK) (NY-REN-35 antigen).