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Network neighborhood for query Sequence : MPIP2_HUMAN

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MPIP2_HUMAN
SwissProt Accessions	P30305, O43551, Q13971, Q5JX77, Q6RSS1, Q9BRA6	Gene names	CDC25B, CDC25HU2
Domain Architecture
Description	M-phase inducer phosphatase 2 (EC 3.1.3.48) (Dual specificity phosphatase Cdc25B).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

MPIP2_HUMAN
θ value	0 (rank : 1)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	18	Target Neighborhood Hits	18	Shared Neighborhood Hits	18
SwissProt Accessions	P30305, O43551, Q13971, Q5JX77, Q6RSS1, Q9BRA6	Gene names	CDC25B, CDC25HU2
Domain Architecture
Description	M-phase inducer phosphatase 2 (EC 3.1.3.48) (Dual specificity phosphatase Cdc25B).

MPIP2_MOUSE
θ value	0 (rank : 2)	NC score	0.993350 (rank : 2)
Query Neighborhood Hits	18	Target Neighborhood Hits	36	Shared Neighborhood Hits	9
SwissProt Accessions	P30306, Q99LP3	Gene names	Cdc25b, Cdc25m2
Domain Architecture
Description	M-phase inducer phosphatase 2 (EC 3.1.3.48) (Dual specificity phosphatase Cdc25B).

MPIP1_HUMAN
θ value	7.63087e-108 (rank : 3)	NC score	0.957226 (rank : 4)
Query Neighborhood Hits	18	Target Neighborhood Hits	27	Shared Neighborhood Hits	6
SwissProt Accessions	P30304, Q8IZH5, Q96IL3, Q9H2F2	Gene names	CDC25A
Domain Architecture
Description	M-phase inducer phosphatase 1 (EC 3.1.3.48) (Dual specificity phosphatase Cdc25A).

MPIP1_MOUSE
θ value	9.32813e-106 (rank : 4)	NC score	0.960918 (rank : 3)
Query Neighborhood Hits	18	Target Neighborhood Hits	31	Shared Neighborhood Hits	6
SwissProt Accessions	P48964	Gene names	Cdc25a, Cdc25m3
Domain Architecture
Description	M-phase inducer phosphatase 1 (EC 3.1.3.48) (Dual specificity phosphatase Cdc25A).

MPIP3_HUMAN
θ value	1.27248e-70 (rank : 5)	NC score	0.932946 (rank : 5)
Query Neighborhood Hits	18	Target Neighborhood Hits	24	Shared Neighborhood Hits	9
SwissProt Accessions	P30307, Q96PL3, Q9H168, Q9H2E8, Q9H2E9, Q9H2F1	Gene names	CDC25C
Domain Architecture
Description	M-phase inducer phosphatase 3 (EC 3.1.3.48) (Dual specificity phosphatase Cdc25C).

MPIP3_MOUSE
θ value	5.35859e-61 (rank : 6)	NC score	0.926370 (rank : 6)
Query Neighborhood Hits	18	Target Neighborhood Hits	17	Shared Neighborhood Hits	9
SwissProt Accessions	P48967, Q99KG6	Gene names	Cdc25c, Cdc25m1
Domain Architecture
Description	M-phase inducer phosphatase 3 (EC 3.1.3.48) (Dual specificity phosphatase Cdc25C).

DUS5_HUMAN
θ value	0.0252991 (rank : 7)	NC score	0.064875 (rank : 7)
Query Neighborhood Hits	18	Target Neighborhood Hits	82	Shared Neighborhood Hits	7
SwissProt Accessions	Q16690, Q12997	Gene names	DUSP5, VH3
Domain Architecture
Description	Dual specificity protein phosphatase 5 (EC 3.1.3.48) (EC 3.1.3.16) (Dual specificity protein phosphatase hVH3).

DJBP_MOUSE
θ value	1.06291 (rank : 8)	NC score	0.026727 (rank : 10)
Query Neighborhood Hits	18	Target Neighborhood Hits	152	Shared Neighborhood Hits	3
SwissProt Accessions	Q6P1E8, Q5DTV8, Q6PGK8, Q9D2D8	Gene names	Djbp, Kiaa1672
Domain Architecture	No domain graphic available
Description	DJ-1-binding protein.

FMN1B_MOUSE
θ value	1.38821 (rank : 9)	NC score	0.016421 (rank : 12)
Query Neighborhood Hits	18	Target Neighborhood Hits	447	Shared Neighborhood Hits	5
SwissProt Accessions	Q05859	Gene names	Fmn, Ld
Domain Architecture
Description	Formin-1 isoform IV (Limb deformity protein).

ZN438_HUMAN
θ value	1.81305 (rank : 10)	NC score	0.005683 (rank : 14)
Query Neighborhood Hits	18	Target Neighborhood Hits	906	Shared Neighborhood Hits	3
SwissProt Accessions	Q7Z4V0, Q5T426, Q658Q4, Q6ZN65	Gene names	ZNF438
Domain Architecture	No domain graphic available
Description	Zinc finger protein 438.

DUS4_MOUSE
θ value	2.36792 (rank : 11)	NC score	0.037613 (rank : 8)
Query Neighborhood Hits	18	Target Neighborhood Hits	75	Shared Neighborhood Hits	7
SwissProt Accessions	Q8BFV3	Gene names	Dusp4
Domain Architecture	No domain graphic available
Description	Dual specificity protein phosphatase 4 (EC 3.1.3.48) (EC 3.1.3.16).

TRAIP_HUMAN
θ value	2.36792 (rank : 12)	NC score	0.009878 (rank : 13)
Query Neighborhood Hits	18	Target Neighborhood Hits	780	Shared Neighborhood Hits	3
SwissProt Accessions	Q9BWF2, O00467	Gene names	TRAIP, TRIP
Domain Architecture
Description	TRAF-interacting protein.

HEAT3_MOUSE
θ value	4.03905 (rank : 13)	NC score	0.018691 (rank : 11)
Query Neighborhood Hits	18	Target Neighborhood Hits	30	Shared Neighborhood Hits	2
SwissProt Accessions	Q8BQM4, Q8C731	Gene names	Heatr3
Domain Architecture
Description	HEAT repeat-containing protein 3.

DUS4_HUMAN
θ value	6.88961 (rank : 14)	NC score	0.033814 (rank : 9)
Query Neighborhood Hits	18	Target Neighborhood Hits	77	Shared Neighborhood Hits	8
SwissProt Accessions	Q13115, Q13524	Gene names	DUSP4, MKP2, VH2
Domain Architecture
Description	Dual specificity protein phosphatase 4 (EC 3.1.3.48) (EC 3.1.3.16) (Mitogen-activated protein kinase phosphatase 2) (MAP kinase phosphatase 2) (MKP-2) (Dual specificity protein phosphatase hVH2).

HUWE1_MOUSE
θ value	8.99809 (rank : 15)	NC score	0.004247 (rank : 15)
Query Neighborhood Hits	18	Target Neighborhood Hits	406	Shared Neighborhood Hits	3
SwissProt Accessions	Q7TMY8, Q4G2Z1, Q5BMM7, Q6NS61, Q8BNJ7, Q8CFH2, Q8VD14, Q921M5, Q9R0P2	Gene names	Huwe1, Kiaa0312, Ureb1
Domain Architecture	No domain graphic available
Description	HECT, UBA and WWE domain-containing protein 1 (EC 6.3.2.-) (E3 ubiquitin protein ligase URE-B1) (E3Histone).

MACF1_MOUSE
θ value	8.99809 (rank : 16)	NC score	0.001825 (rank : 17)
Query Neighborhood Hits	18	Target Neighborhood Hits	1313	Shared Neighborhood Hits	6
SwissProt Accessions	Q9QXZ0, P97394, P97395, P97396	Gene names	Macf1, Acf7, Aclp7, Macf
Domain Architecture
Description	Microtubule-actin cross-linking factor 1 (Actin cross-linking family 7).

NUCL_HUMAN
θ value	8.99809 (rank : 17)	NC score	0.004095 (rank : 16)
Query Neighborhood Hits	18	Target Neighborhood Hits	415	Shared Neighborhood Hits	2
SwissProt Accessions	P19338, Q53SK1, Q8NB06	Gene names	NCL
Domain Architecture
Description	Nucleolin (Protein C23).

WNK4_HUMAN
θ value	8.99809 (rank : 18)	NC score	-0.000230 (rank : 18)
Query Neighborhood Hits	18	Target Neighborhood Hits	1043	Shared Neighborhood Hits	4
SwissProt Accessions	Q96J92, Q8N8X3, Q8N8Z2, Q96DT8, Q9BYS5	Gene names	WNK4, PRKWNK4
Domain Architecture
Description	Serine/threonine-protein kinase WNK4 (EC 2.7.11.1) (Protein kinase with no lysine 4) (Protein kinase, lysine-deficient 4).

Hits sorted by NC score

MPIP2_HUMAN
NC score	0.999962 (rank : 1)	θ value	0 (rank : 1)
Query Neighborhood Hits	18	Target Neighborhood Hits	18	Shared Neighborhood Hits	18
SwissProt Accessions	P30305, O43551, Q13971, Q5JX77, Q6RSS1, Q9BRA6	Gene names	CDC25B, CDC25HU2
Domain Architecture
Description	M-phase inducer phosphatase 2 (EC 3.1.3.48) (Dual specificity phosphatase Cdc25B).

MPIP2_MOUSE
NC score	0.993350 (rank : 2)	θ value	0 (rank : 2)
Query Neighborhood Hits	18	Target Neighborhood Hits	36	Shared Neighborhood Hits	9
SwissProt Accessions	P30306, Q99LP3	Gene names	Cdc25b, Cdc25m2
Domain Architecture
Description	M-phase inducer phosphatase 2 (EC 3.1.3.48) (Dual specificity phosphatase Cdc25B).

MPIP1_MOUSE
NC score	0.960918 (rank : 3)	θ value	9.32813e-106 (rank : 4)
Query Neighborhood Hits	18	Target Neighborhood Hits	31	Shared Neighborhood Hits	6
SwissProt Accessions	P48964	Gene names	Cdc25a, Cdc25m3
Domain Architecture
Description	M-phase inducer phosphatase 1 (EC 3.1.3.48) (Dual specificity phosphatase Cdc25A).

MPIP1_HUMAN
NC score	0.957226 (rank : 4)	θ value	7.63087e-108 (rank : 3)
Query Neighborhood Hits	18	Target Neighborhood Hits	27	Shared Neighborhood Hits	6
SwissProt Accessions	P30304, Q8IZH5, Q96IL3, Q9H2F2	Gene names	CDC25A
Domain Architecture
Description	M-phase inducer phosphatase 1 (EC 3.1.3.48) (Dual specificity phosphatase Cdc25A).

MPIP3_HUMAN
NC score	0.932946 (rank : 5)	θ value	1.27248e-70 (rank : 5)
Query Neighborhood Hits	18	Target Neighborhood Hits	24	Shared Neighborhood Hits	9
SwissProt Accessions	P30307, Q96PL3, Q9H168, Q9H2E8, Q9H2E9, Q9H2F1	Gene names	CDC25C
Domain Architecture
Description	M-phase inducer phosphatase 3 (EC 3.1.3.48) (Dual specificity phosphatase Cdc25C).

MPIP3_MOUSE
NC score	0.926370 (rank : 6)	θ value	5.35859e-61 (rank : 6)
Query Neighborhood Hits	18	Target Neighborhood Hits	17	Shared Neighborhood Hits	9
SwissProt Accessions	P48967, Q99KG6	Gene names	Cdc25c, Cdc25m1
Domain Architecture
Description	M-phase inducer phosphatase 3 (EC 3.1.3.48) (Dual specificity phosphatase Cdc25C).

DUS5_HUMAN
NC score	0.064875 (rank : 7)	θ value	0.0252991 (rank : 7)
Query Neighborhood Hits	18	Target Neighborhood Hits	82	Shared Neighborhood Hits	7
SwissProt Accessions	Q16690, Q12997	Gene names	DUSP5, VH3
Domain Architecture
Description	Dual specificity protein phosphatase 5 (EC 3.1.3.48) (EC 3.1.3.16) (Dual specificity protein phosphatase hVH3).

DUS4_MOUSE
NC score	0.037613 (rank : 8)	θ value	2.36792 (rank : 11)
Query Neighborhood Hits	18	Target Neighborhood Hits	75	Shared Neighborhood Hits	7
SwissProt Accessions	Q8BFV3	Gene names	Dusp4
Domain Architecture	No domain graphic available
Description	Dual specificity protein phosphatase 4 (EC 3.1.3.48) (EC 3.1.3.16).

DUS4_HUMAN
NC score	0.033814 (rank : 9)	θ value	6.88961 (rank : 14)
Query Neighborhood Hits	18	Target Neighborhood Hits	77	Shared Neighborhood Hits	8
SwissProt Accessions	Q13115, Q13524	Gene names	DUSP4, MKP2, VH2
Domain Architecture
Description	Dual specificity protein phosphatase 4 (EC 3.1.3.48) (EC 3.1.3.16) (Mitogen-activated protein kinase phosphatase 2) (MAP kinase phosphatase 2) (MKP-2) (Dual specificity protein phosphatase hVH2).

DJBP_MOUSE
NC score	0.026727 (rank : 10)	θ value	1.06291 (rank : 8)
Query Neighborhood Hits	18	Target Neighborhood Hits	152	Shared Neighborhood Hits	3
SwissProt Accessions	Q6P1E8, Q5DTV8, Q6PGK8, Q9D2D8	Gene names	Djbp, Kiaa1672
Domain Architecture	No domain graphic available
Description	DJ-1-binding protein.

HEAT3_MOUSE
NC score	0.018691 (rank : 11)	θ value	4.03905 (rank : 13)
Query Neighborhood Hits	18	Target Neighborhood Hits	30	Shared Neighborhood Hits	2
SwissProt Accessions	Q8BQM4, Q8C731	Gene names	Heatr3
Domain Architecture
Description	HEAT repeat-containing protein 3.

FMN1B_MOUSE
NC score	0.016421 (rank : 12)	θ value	1.38821 (rank : 9)
Query Neighborhood Hits	18	Target Neighborhood Hits	447	Shared Neighborhood Hits	5
SwissProt Accessions	Q05859	Gene names	Fmn, Ld
Domain Architecture
Description	Formin-1 isoform IV (Limb deformity protein).

TRAIP_HUMAN
NC score	0.009878 (rank : 13)	θ value	2.36792 (rank : 12)
Query Neighborhood Hits	18	Target Neighborhood Hits	780	Shared Neighborhood Hits	3
SwissProt Accessions	Q9BWF2, O00467	Gene names	TRAIP, TRIP
Domain Architecture
Description	TRAF-interacting protein.

ZN438_HUMAN
NC score	0.005683 (rank : 14)	θ value	1.81305 (rank : 10)
Query Neighborhood Hits	18	Target Neighborhood Hits	906	Shared Neighborhood Hits	3
SwissProt Accessions	Q7Z4V0, Q5T426, Q658Q4, Q6ZN65	Gene names	ZNF438
Domain Architecture	No domain graphic available
Description	Zinc finger protein 438.

HUWE1_MOUSE
NC score	0.004247 (rank : 15)	θ value	8.99809 (rank : 15)
Query Neighborhood Hits	18	Target Neighborhood Hits	406	Shared Neighborhood Hits	3
SwissProt Accessions	Q7TMY8, Q4G2Z1, Q5BMM7, Q6NS61, Q8BNJ7, Q8CFH2, Q8VD14, Q921M5, Q9R0P2	Gene names	Huwe1, Kiaa0312, Ureb1
Domain Architecture	No domain graphic available
Description	HECT, UBA and WWE domain-containing protein 1 (EC 6.3.2.-) (E3 ubiquitin protein ligase URE-B1) (E3Histone).

NUCL_HUMAN
NC score	0.004095 (rank : 16)	θ value	8.99809 (rank : 17)
Query Neighborhood Hits	18	Target Neighborhood Hits	415	Shared Neighborhood Hits	2
SwissProt Accessions	P19338, Q53SK1, Q8NB06	Gene names	NCL
Domain Architecture
Description	Nucleolin (Protein C23).

MACF1_MOUSE
NC score	0.001825 (rank : 17)	θ value	8.99809 (rank : 16)
Query Neighborhood Hits	18	Target Neighborhood Hits	1313	Shared Neighborhood Hits	6
SwissProt Accessions	Q9QXZ0, P97394, P97395, P97396	Gene names	Macf1, Acf7, Aclp7, Macf
Domain Architecture
Description	Microtubule-actin cross-linking factor 1 (Actin cross-linking family 7).

WNK4_HUMAN
NC score	-0.000230 (rank : 18)	θ value	8.99809 (rank : 18)
Query Neighborhood Hits	18	Target Neighborhood Hits	1043	Shared Neighborhood Hits	4
SwissProt Accessions	Q96J92, Q8N8X3, Q8N8Z2, Q96DT8, Q9BYS5	Gene names	WNK4, PRKWNK4
Domain Architecture
Description	Serine/threonine-protein kinase WNK4 (EC 2.7.11.1) (Protein kinase with no lysine 4) (Protein kinase, lysine-deficient 4).