Please be patient as the page loads

Stop Image Loading/Displaying

Network neighborhood for query Sequence : KCAB3_HUMAN

For an explanation of this page, click here

KCAB3_HUMAN
SwissProt Accessions	O43448	Gene names	KCNAB3, KCNA3B
Domain Architecture
Description	Voltage-gated potassium channel subunit beta-3 (K(+) channel subunit beta-3) (Kv-beta-3).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

KCAB3_HUMAN
θ value	0 (rank : 1)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	28	Target Neighborhood Hits	28	Shared Neighborhood Hits	28
SwissProt Accessions	O43448	Gene names	KCNAB3, KCNA3B
Domain Architecture
Description	Voltage-gated potassium channel subunit beta-3 (K(+) channel subunit beta-3) (Kv-beta-3).

KCAB1_MOUSE
θ value	4.87785e-155 (rank : 2)	NC score	0.986413 (rank : 4)
Query Neighborhood Hits	28	Target Neighborhood Hits	27	Shared Neighborhood Hits	17
SwissProt Accessions	P63143, P97380, Q61763, Q63277	Gene names	Kcnab1, Kvb1
Domain Architecture	No domain graphic available
Description	Voltage-gated potassium channel subunit beta-1 (K(+) channel subunit beta-1) (Kv-beta-1).

KCAB1_HUMAN
θ value	1.85788e-146 (rank : 3)	NC score	0.985504 (rank : 6)
Query Neighborhood Hits	28	Target Neighborhood Hits	29	Shared Neighborhood Hits	17
SwissProt Accessions	Q14722, Q13031, Q13302, Q16547, Q99869	Gene names	KCNAB1, KCNA1B
Domain Architecture
Description	Voltage-gated potassium channel subunit beta-1 (K(+) channel subunit beta-1) (Kv-beta-1).

KCAB2_MOUSE
θ value	1.85788e-146 (rank : 4)	NC score	0.986362 (rank : 5)
Query Neighborhood Hits	28	Target Neighborhood Hits	22	Shared Neighborhood Hits	16
SwissProt Accessions	P62482, P97381, Q60942, Q64284	Gene names	Kcnab2, Ckbeta2, I2rf5, Kcnb3
Domain Architecture
Description	Voltage-gated potassium channel subunit beta-2 (K(+) channel subunit beta-2) (Kv-beta-2) (Neuroimmune protein F5).

KCAB2_HUMAN
θ value	1.57279e-145 (rank : 5)	NC score	0.986714 (rank : 3)
Query Neighborhood Hits	28	Target Neighborhood Hits	24	Shared Neighborhood Hits	17
SwissProt Accessions	Q13303, O43659, Q5TG82, Q5TG83, Q99411	Gene names	KCNAB2, KCNA2B, KCNK2
Domain Architecture
Description	Voltage-gated potassium channel subunit beta-2 (K(+) channel subunit beta-2) (Kv-beta-2) (HKvbeta2).

KCAB3_MOUSE
θ value	1.81628e-109 (rank : 6)	NC score	0.992151 (rank : 2)
Query Neighborhood Hits	28	Target Neighborhood Hits	16	Shared Neighborhood Hits	11
SwissProt Accessions	P97382	Gene names	Kcnab3
Domain Architecture
Description	Voltage-gated potassium channel subunit beta-3 (K(+) channel subunit beta-3) (Kv-beta-3).

ARK72_MOUSE
θ value	1.33837e-11 (rank : 7)	NC score	0.598121 (rank : 7)
Query Neighborhood Hits	28	Target Neighborhood Hits	24	Shared Neighborhood Hits	15
SwissProt Accessions	Q8CG76, Q3UPU2, Q8CG77, Q8JZQ8, Q9D157	Gene names	Akr7a2, Afar, Akr7a5
Domain Architecture
Description	Aflatoxin B1 aldehyde reductase member 2 (EC 1.-.-.-).

ARK72_HUMAN
θ value	1.74796e-11 (rank : 8)	NC score	0.591819 (rank : 8)
Query Neighborhood Hits	28	Target Neighborhood Hits	24	Shared Neighborhood Hits	15
SwissProt Accessions	O43488, O75749, Q5TG63	Gene names	AKR7A2, AFAR, AFAR1, AKR7
Domain Architecture
Description	Aflatoxin B1 aldehyde reductase member 2 (EC 1.-.-.-) (AFB1-AR 1) (Aldoketoreductase 7).

ARK73_HUMAN
θ value	1.47974e-10 (rank : 9)	NC score	0.585343 (rank : 9)
Query Neighborhood Hits	28	Target Neighborhood Hits	19	Shared Neighborhood Hits	15
SwissProt Accessions	O95154, Q86SR4, Q8IVN6, Q8N5V6, Q8TAX1, Q9NUC3	Gene names	AKR7A3, AFAR2
Domain Architecture
Description	Aflatoxin B1 aldehyde reductase member 3 (EC 1.-.-.-) (AFB1-AR 2).

AK1A1_MOUSE
θ value	0.0431538 (rank : 10)	NC score	0.162830 (rank : 10)
Query Neighborhood Hits	28	Target Neighborhood Hits	29	Shared Neighborhood Hits	15
SwissProt Accessions	Q9JII6, Q9CQI5, Q9CQT8, Q9CT53, Q9D012, Q9D016, Q9D0I7, Q9D0P3	Gene names	Akr1a1, Akr1a4
Domain Architecture
Description	Alcohol dehydrogenase [NADP+] (EC 1.1.1.2) (Aldehyde reductase) (Aldo- keto reductase family 1 member A1).

AK1A1_HUMAN
θ value	0.0736092 (rank : 11)	NC score	0.144147 (rank : 11)
Query Neighborhood Hits	28	Target Neighborhood Hits	29	Shared Neighborhood Hits	15
SwissProt Accessions	P14550	Gene names	AKR1A1, ALDR1, ALR
Domain Architecture
Description	Alcohol dehydrogenase [NADP+] (EC 1.1.1.2) (Aldehyde reductase) (Aldo- keto reductase family 1 member A1).

AK1C2_HUMAN
θ value	0.279714 (rank : 12)	NC score	0.117197 (rank : 13)
Query Neighborhood Hits	28	Target Neighborhood Hits	28	Shared Neighborhood Hits	15
SwissProt Accessions	P52895, Q14133, Q96A71	Gene names	AKR1C2, DDH2
Domain Architecture
Description	Aldo-keto reductase family 1 member C2 (EC 1.-.-.-) (Trans-1,2- dihydrobenzene-1,2-diol dehydrogenase) (EC 1.3.1.20) (Type III 3- alpha-hydroxysteroid dehydrogenase) (EC 1.1.1.213) (3-alpha-HSD3) (Chlordecone reductase homolog HAKRD) (Dihydrodiol dehydrogenase/bile acid-binding protein) (DD/BABP) (Dihydrodiol dehydrogenase 2) (DD2).

CO7A1_HUMAN
θ value	0.365318 (rank : 13)	NC score	0.012473 (rank : 27)
Query Neighborhood Hits	28	Target Neighborhood Hits	807	Shared Neighborhood Hits	7
SwissProt Accessions	Q02388, Q14054, Q16507	Gene names	COL7A1
Domain Architecture
Description	Collagen alpha-1(VII) chain precursor (Long-chain collagen) (LC collagen).

RIB2_HUMAN
θ value	0.365318 (rank : 14)	NC score	0.045330 (rank : 24)
Query Neighborhood Hits	28	Target Neighborhood Hits	9	Shared Neighborhood Hits	4
SwissProt Accessions	P04844, Q6IBA5, Q96E21, Q9BUQ3, Q9UBE1	Gene names	RPN2
Domain Architecture
Description	Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 63 kDa subunit precursor (EC 2.4.1.119) (Ribophorin II) (RPN-II) (RIBIIR).

CO5A2_HUMAN
θ value	0.47712 (rank : 15)	NC score	0.013495 (rank : 26)
Query Neighborhood Hits	28	Target Neighborhood Hits	760	Shared Neighborhood Hits	5
SwissProt Accessions	P05997	Gene names	COL5A2
Domain Architecture
Description	Collagen alpha-2(V) chain precursor.

ALDR_MOUSE
θ value	1.38821 (rank : 16)	NC score	0.136495 (rank : 12)
Query Neighborhood Hits	28	Target Neighborhood Hits	25	Shared Neighborhood Hits	12
SwissProt Accessions	P45376, O70130, Q99KC9	Gene names	Akr1b1, Akr1b3, Aldor1, Aldr1
Domain Architecture
Description	Aldose reductase (EC 1.1.1.21) (AR) (Aldehyde reductase).

AK1CD_MOUSE
θ value	1.81305 (rank : 17)	NC score	0.097374 (rank : 17)
Query Neighborhood Hits	28	Target Neighborhood Hits	33	Shared Neighborhood Hits	15
SwissProt Accessions	Q8VC28, Q9D7R9, Q9R0M9	Gene names	Akr1c13
Domain Architecture
Description	Aldo-keto reductase family 1 member C13 (EC 1.1.1.-).

EPHA5_HUMAN
θ value	2.36792 (rank : 18)	NC score	0.000476 (rank : 35)
Query Neighborhood Hits	28	Target Neighborhood Hits	1009	Shared Neighborhood Hits	3
SwissProt Accessions	P54756	Gene names	EPHA5, EHK1, HEK7
Domain Architecture
Description	Ephrin type-A receptor 5 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EHK-1) (EPH homology kinase 1) (Receptor protein- tyrosine kinase HEK7).

AK1C1_HUMAN
θ value	3.0926 (rank : 19)	NC score	0.100161 (rank : 16)
Query Neighborhood Hits	28	Target Neighborhood Hits	29	Shared Neighborhood Hits	15
SwissProt Accessions	Q04828, P52896, Q5SR15, Q9UCX2	Gene names	AKR1C1, DDH, DDH1
Domain Architecture
Description	Aldo-keto reductase family 1 member C1 (EC 1.1.1.-) (20-alpha- hydroxysteroid dehydrogenase) (EC 1.1.1.149) (20-alpha-HSD) (Trans- 1,2-dihydrobenzene-1,2-diol dehydrogenase) (EC 1.3.1.20) (High- affinity hepatic bile acid-binding protein) (HBAB) (Chlordecone reductase homolog HAKRC) (Dihydrodiol dehydrogenase 1/2) (DD1/DD2).

AK1C3_HUMAN
θ value	3.0926 (rank : 20)	NC score	0.096337 (rank : 18)
Query Neighborhood Hits	28	Target Neighborhood Hits	30	Shared Neighborhood Hits	16
SwissProt Accessions	P42330, Q5T2L1, Q96DJ1, Q96KI8, Q99530, Q9UCX1, Q9UII3, Q9UKL9	Gene names	AKR1C3, DDH1, KIAA0119, PGFS
Domain Architecture
Description	Aldo-keto reductase family 1 member C3 (EC 1.-.-.-) (Trans-1,2- dihydrobenzene-1,2-diol dehydrogenase) (EC 1.3.1.20) (3-alpha- hydroxysteroid dehydrogenase type 2) (EC 1.1.1.213) (3-alpha-HSD type 2) (3-alpha-HSD type II, brain) (Prostaglandin F synthase) (EC 1.1.1.188) (PGFS) (Estradiol 17-beta-dehydrogenase) (EC 1.1.1.62) (17-beta-hydroxysteroid dehydrogenase type 5) (17-beta-HSD 5) (Chlordecone reductase homolog HAKRb) (HA1753) (Dihydrodiol dehydrogenase type I) (Dihydrodiol dehydrogenase 3) (DD3) (DD-3).

CO9A1_HUMAN
θ value	3.0926 (rank : 21)	NC score	0.012412 (rank : 29)
Query Neighborhood Hits	28	Target Neighborhood Hits	420	Shared Neighborhood Hits	5
SwissProt Accessions	P20849, Q13699, Q13700, Q5TF52, Q6P467, Q96BM8, Q99225, Q9H151, Q9H152, Q9Y6P2, Q9Y6P3	Gene names	COL9A1
Domain Architecture
Description	Collagen alpha-1(IX) chain precursor.

DPOLZ_MOUSE
θ value	4.03905 (rank : 22)	NC score	0.012465 (rank : 28)
Query Neighborhood Hits	28	Target Neighborhood Hits	169	Shared Neighborhood Hits	4
SwissProt Accessions	Q61493, Q9JMD6, Q9QWX6	Gene names	Rev3l, Polz, Sez4
Domain Architecture
Description	DNA polymerase zeta catalytic subunit (EC 2.7.7.7) (Seizure-related protein 4).

TTC5_MOUSE
θ value	4.03905 (rank : 23)	NC score	0.036911 (rank : 25)
Query Neighborhood Hits	28	Target Neighborhood Hits	51	Shared Neighborhood Hits	5
SwissProt Accessions	Q99LG4	Gene names	Ttc5
Domain Architecture	No domain graphic available
Description	Tetratricopeptide repeat protein 5 (TPR repeat protein 5).

PDZD2_HUMAN
θ value	5.27518 (rank : 24)	NC score	0.006588 (rank : 32)
Query Neighborhood Hits	28	Target Neighborhood Hits	772	Shared Neighborhood Hits	4
SwissProt Accessions	O15018, Q9BXD4	Gene names	PDZD2, AIPC, KIAA0300, PDZK3
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 2 (PDZ domain-containing protein 3) (Activated in prostate cancer protein).

B4GT1_HUMAN
θ value	6.88961 (rank : 25)	NC score	0.006088 (rank : 33)
Query Neighborhood Hits	28	Target Neighborhood Hits	168	Shared Neighborhood Hits	2
SwissProt Accessions	P15291, Q12909, Q12910, Q12911, Q14456, Q14509, Q14523	Gene names	B4GALT1, GGTB2
Domain Architecture
Description	Beta-1,4-galactosyltransferase 1 (EC 2.4.1.-) (Beta-1,4-GalTase 1) (Beta4Gal-T1) (b4Gal-T1) (UDP-galactose:beta-N-acetylglucosamine beta- 1,4-galactosyltransferase 1) (UDP-Gal:beta-GlcNAc beta-1,4- galactosyltransferase 1) [Includes: Lactose synthase A protein (EC 2.4.1.22); N-acetyllactosamine synthase (EC 2.4.1.90) (Nal synthetase); Beta-N-acetylglucosaminylglycopeptide beta-1,4- galactosyltransferase (EC 2.4.1.38); Beta-N-acetylglucosaminyl- glycolipid beta-1,4-galactosyltransferase (EC 2.4.1.-)].

JHD2A_MOUSE
θ value	6.88961 (rank : 26)	NC score	0.006884 (rank : 31)
Query Neighborhood Hits	28	Target Neighborhood Hits	123	Shared Neighborhood Hits	2
SwissProt Accessions	Q6PCM1, Q2MJQ6, Q3TKW8, Q3UML3, Q6ZQ57, Q8K2J6, Q8K2K4, Q8R350	Gene names	Jmjd1a, Jhdm2a, Kiaa0742
Domain Architecture	No domain graphic available
Description	JmjC domain-containing histone demethylation protein 2A (EC 1.14.11.-) (Jumonji domain-containing protein 1A).

CO9A1_MOUSE
θ value	8.99809 (rank : 27)	NC score	0.010365 (rank : 30)
Query Neighborhood Hits	28	Target Neighborhood Hits	477	Shared Neighborhood Hits	5
SwissProt Accessions	Q05722, Q61269, Q61270, Q61433, Q61940	Gene names	Col9a1
Domain Architecture
Description	Collagen alpha-1(IX) chain precursor.

P2RX3_HUMAN
θ value	8.99809 (rank : 28)	NC score	0.006041 (rank : 34)
Query Neighborhood Hits	28	Target Neighborhood Hits	12	Shared Neighborhood Hits	2
SwissProt Accessions	P56373, Q9UQB6	Gene names	P2RX3
Domain Architecture
Description	P2X purinoceptor 3 (ATP receptor) (P2X3) (Purinergic receptor).

AK1C4_HUMAN
θ value	θ > 10 (rank : 29)	NC score	0.076031 (rank : 20)
Query Neighborhood Hits	28	Target Neighborhood Hits	28	Shared Neighborhood Hits	14
SwissProt Accessions	P17516, Q5T6A3, Q8WW84, Q9NS54	Gene names	AKR1C4, CHDR
Domain Architecture
Description	Aldo-keto reductase family 1 member C4 (EC 1.1.1.-) (Chlordecone reductase) (EC 1.1.1.225) (CDR) (3-alpha-hydroxysteroid dehydrogenase type I) (EC 1.1.1.50) (3-alpha-HSD1) (Dihydrodiol dehydrogenase 4) (DD4) (HAKRA).

AK1D1_HUMAN
θ value	θ > 10 (rank : 30)	NC score	0.051484 (rank : 23)
Query Neighborhood Hits	28	Target Neighborhood Hits	29	Shared Neighborhood Hits	10
SwissProt Accessions	P51857	Gene names	AKR1D1, SRD5B1
Domain Architecture
Description	3-oxo-5-beta-steroid 4-dehydrogenase (EC 1.3.1.3) (Delta(4)-3- ketosteroid 5-beta-reductase) (Aldo-keto reductase family 1 member D1).

AK1E1_MOUSE
θ value	θ > 10 (rank : 31)	NC score	0.101907 (rank : 14)
Query Neighborhood Hits	28	Target Neighborhood Hits	26	Shared Neighborhood Hits	11
SwissProt Accessions	Q9DCT1, O09125	Gene names	Akr1e1
Domain Architecture
Description	Aldo-keto reductase family 1 member E1 (EC 1.1.1.-).

AKC1H_MOUSE
θ value	θ > 10 (rank : 32)	NC score	0.066256 (rank : 22)
Query Neighborhood Hits	28	Target Neighborhood Hits	22	Shared Neighborhood Hits	12
SwissProt Accessions	Q8K023, Q99N44	Gene names	Akr1c18
Domain Architecture	No domain graphic available
Description	Aldo-keto reductase family 1 member C18 (EC 1.1.-.-) (20-alpha- hydroxysteroid dehydrogenase) (EC 1.1.1.149) (20-alpha-HSD).

ALD1_MOUSE
θ value	θ > 10 (rank : 33)	NC score	0.090138 (rank : 19)
Query Neighborhood Hits	28	Target Neighborhood Hits	22	Shared Neighborhood Hits	11
SwissProt Accessions	P21300	Gene names	Akr1b7, Avdp
Domain Architecture
Description	Aldose reductase-related protein 1 (EC 1.1.1.21) (AR) (Aldehyde reductase) (VAS deferens androgen-dependent protein) (MVDP) (Aldo-keto reductase family 1 member B7).

ALDR_HUMAN
θ value	θ > 10 (rank : 34)	NC score	0.101095 (rank : 15)
Query Neighborhood Hits	28	Target Neighborhood Hits	26	Shared Neighborhood Hits	11
SwissProt Accessions	P15121, Q9BS21, Q9UCI9	Gene names	AKR1B1, ALDR1
Domain Architecture
Description	Aldose reductase (EC 1.1.1.21) (AR) (Aldehyde reductase).

DHB5_MOUSE
θ value	θ > 10 (rank : 35)	NC score	0.076027 (rank : 21)
Query Neighborhood Hits	28	Target Neighborhood Hits	26	Shared Neighborhood Hits	14
SwissProt Accessions	P70694	Gene names	Akr1c6, Hsd17b5
Domain Architecture
Description	Estradiol 17 beta-dehydrogenase 5 (EC 1.1.1.-) (17-beta-HSD 5).

Hits sorted by NC score

KCAB3_HUMAN
NC score	0.999962 (rank : 1)	θ value	0 (rank : 1)
Query Neighborhood Hits	28	Target Neighborhood Hits	28	Shared Neighborhood Hits	28
SwissProt Accessions	O43448	Gene names	KCNAB3, KCNA3B
Domain Architecture
Description	Voltage-gated potassium channel subunit beta-3 (K(+) channel subunit beta-3) (Kv-beta-3).

KCAB3_MOUSE
NC score	0.992151 (rank : 2)	θ value	1.81628e-109 (rank : 6)
Query Neighborhood Hits	28	Target Neighborhood Hits	16	Shared Neighborhood Hits	11
SwissProt Accessions	P97382	Gene names	Kcnab3
Domain Architecture
Description	Voltage-gated potassium channel subunit beta-3 (K(+) channel subunit beta-3) (Kv-beta-3).

KCAB2_HUMAN
NC score	0.986714 (rank : 3)	θ value	1.57279e-145 (rank : 5)
Query Neighborhood Hits	28	Target Neighborhood Hits	24	Shared Neighborhood Hits	17
SwissProt Accessions	Q13303, O43659, Q5TG82, Q5TG83, Q99411	Gene names	KCNAB2, KCNA2B, KCNK2
Domain Architecture
Description	Voltage-gated potassium channel subunit beta-2 (K(+) channel subunit beta-2) (Kv-beta-2) (HKvbeta2).

KCAB1_MOUSE
NC score	0.986413 (rank : 4)	θ value	4.87785e-155 (rank : 2)
Query Neighborhood Hits	28	Target Neighborhood Hits	27	Shared Neighborhood Hits	17
SwissProt Accessions	P63143, P97380, Q61763, Q63277	Gene names	Kcnab1, Kvb1
Domain Architecture	No domain graphic available
Description	Voltage-gated potassium channel subunit beta-1 (K(+) channel subunit beta-1) (Kv-beta-1).

KCAB2_MOUSE
NC score	0.986362 (rank : 5)	θ value	1.85788e-146 (rank : 4)
Query Neighborhood Hits	28	Target Neighborhood Hits	22	Shared Neighborhood Hits	16
SwissProt Accessions	P62482, P97381, Q60942, Q64284	Gene names	Kcnab2, Ckbeta2, I2rf5, Kcnb3
Domain Architecture
Description	Voltage-gated potassium channel subunit beta-2 (K(+) channel subunit beta-2) (Kv-beta-2) (Neuroimmune protein F5).

KCAB1_HUMAN
NC score	0.985504 (rank : 6)	θ value	1.85788e-146 (rank : 3)
Query Neighborhood Hits	28	Target Neighborhood Hits	29	Shared Neighborhood Hits	17
SwissProt Accessions	Q14722, Q13031, Q13302, Q16547, Q99869	Gene names	KCNAB1, KCNA1B
Domain Architecture
Description	Voltage-gated potassium channel subunit beta-1 (K(+) channel subunit beta-1) (Kv-beta-1).

ARK72_MOUSE
NC score	0.598121 (rank : 7)	θ value	1.33837e-11 (rank : 7)
Query Neighborhood Hits	28	Target Neighborhood Hits	24	Shared Neighborhood Hits	15
SwissProt Accessions	Q8CG76, Q3UPU2, Q8CG77, Q8JZQ8, Q9D157	Gene names	Akr7a2, Afar, Akr7a5
Domain Architecture
Description	Aflatoxin B1 aldehyde reductase member 2 (EC 1.-.-.-).

ARK72_HUMAN
NC score	0.591819 (rank : 8)	θ value	1.74796e-11 (rank : 8)
Query Neighborhood Hits	28	Target Neighborhood Hits	24	Shared Neighborhood Hits	15
SwissProt Accessions	O43488, O75749, Q5TG63	Gene names	AKR7A2, AFAR, AFAR1, AKR7
Domain Architecture
Description	Aflatoxin B1 aldehyde reductase member 2 (EC 1.-.-.-) (AFB1-AR 1) (Aldoketoreductase 7).

ARK73_HUMAN
NC score	0.585343 (rank : 9)	θ value	1.47974e-10 (rank : 9)
Query Neighborhood Hits	28	Target Neighborhood Hits	19	Shared Neighborhood Hits	15
SwissProt Accessions	O95154, Q86SR4, Q8IVN6, Q8N5V6, Q8TAX1, Q9NUC3	Gene names	AKR7A3, AFAR2
Domain Architecture
Description	Aflatoxin B1 aldehyde reductase member 3 (EC 1.-.-.-) (AFB1-AR 2).

AK1A1_MOUSE
NC score	0.162830 (rank : 10)	θ value	0.0431538 (rank : 10)
Query Neighborhood Hits	28	Target Neighborhood Hits	29	Shared Neighborhood Hits	15
SwissProt Accessions	Q9JII6, Q9CQI5, Q9CQT8, Q9CT53, Q9D012, Q9D016, Q9D0I7, Q9D0P3	Gene names	Akr1a1, Akr1a4
Domain Architecture
Description	Alcohol dehydrogenase [NADP+] (EC 1.1.1.2) (Aldehyde reductase) (Aldo- keto reductase family 1 member A1).

AK1A1_HUMAN
NC score	0.144147 (rank : 11)	θ value	0.0736092 (rank : 11)
Query Neighborhood Hits	28	Target Neighborhood Hits	29	Shared Neighborhood Hits	15
SwissProt Accessions	P14550	Gene names	AKR1A1, ALDR1, ALR
Domain Architecture
Description	Alcohol dehydrogenase [NADP+] (EC 1.1.1.2) (Aldehyde reductase) (Aldo- keto reductase family 1 member A1).

ALDR_MOUSE
NC score	0.136495 (rank : 12)	θ value	1.38821 (rank : 16)
Query Neighborhood Hits	28	Target Neighborhood Hits	25	Shared Neighborhood Hits	12
SwissProt Accessions	P45376, O70130, Q99KC9	Gene names	Akr1b1, Akr1b3, Aldor1, Aldr1
Domain Architecture
Description	Aldose reductase (EC 1.1.1.21) (AR) (Aldehyde reductase).

AK1C2_HUMAN
NC score	0.117197 (rank : 13)	θ value	0.279714 (rank : 12)
Query Neighborhood Hits	28	Target Neighborhood Hits	28	Shared Neighborhood Hits	15
SwissProt Accessions	P52895, Q14133, Q96A71	Gene names	AKR1C2, DDH2
Domain Architecture
Description	Aldo-keto reductase family 1 member C2 (EC 1.-.-.-) (Trans-1,2- dihydrobenzene-1,2-diol dehydrogenase) (EC 1.3.1.20) (Type III 3- alpha-hydroxysteroid dehydrogenase) (EC 1.1.1.213) (3-alpha-HSD3) (Chlordecone reductase homolog HAKRD) (Dihydrodiol dehydrogenase/bile acid-binding protein) (DD/BABP) (Dihydrodiol dehydrogenase 2) (DD2).

AK1E1_MOUSE
NC score	0.101907 (rank : 14)	θ value	θ > 10 (rank : 31)
Query Neighborhood Hits	28	Target Neighborhood Hits	26	Shared Neighborhood Hits	11
SwissProt Accessions	Q9DCT1, O09125	Gene names	Akr1e1
Domain Architecture
Description	Aldo-keto reductase family 1 member E1 (EC 1.1.1.-).

ALDR_HUMAN
NC score	0.101095 (rank : 15)	θ value	θ > 10 (rank : 34)
Query Neighborhood Hits	28	Target Neighborhood Hits	26	Shared Neighborhood Hits	11
SwissProt Accessions	P15121, Q9BS21, Q9UCI9	Gene names	AKR1B1, ALDR1
Domain Architecture
Description	Aldose reductase (EC 1.1.1.21) (AR) (Aldehyde reductase).

AK1C1_HUMAN
NC score	0.100161 (rank : 16)	θ value	3.0926 (rank : 19)
Query Neighborhood Hits	28	Target Neighborhood Hits	29	Shared Neighborhood Hits	15
SwissProt Accessions	Q04828, P52896, Q5SR15, Q9UCX2	Gene names	AKR1C1, DDH, DDH1
Domain Architecture
Description	Aldo-keto reductase family 1 member C1 (EC 1.1.1.-) (20-alpha- hydroxysteroid dehydrogenase) (EC 1.1.1.149) (20-alpha-HSD) (Trans- 1,2-dihydrobenzene-1,2-diol dehydrogenase) (EC 1.3.1.20) (High- affinity hepatic bile acid-binding protein) (HBAB) (Chlordecone reductase homolog HAKRC) (Dihydrodiol dehydrogenase 1/2) (DD1/DD2).

AK1CD_MOUSE
NC score	0.097374 (rank : 17)	θ value	1.81305 (rank : 17)
Query Neighborhood Hits	28	Target Neighborhood Hits	33	Shared Neighborhood Hits	15
SwissProt Accessions	Q8VC28, Q9D7R9, Q9R0M9	Gene names	Akr1c13
Domain Architecture
Description	Aldo-keto reductase family 1 member C13 (EC 1.1.1.-).

AK1C3_HUMAN
NC score	0.096337 (rank : 18)	θ value	3.0926 (rank : 20)
Query Neighborhood Hits	28	Target Neighborhood Hits	30	Shared Neighborhood Hits	16
SwissProt Accessions	P42330, Q5T2L1, Q96DJ1, Q96KI8, Q99530, Q9UCX1, Q9UII3, Q9UKL9	Gene names	AKR1C3, DDH1, KIAA0119, PGFS
Domain Architecture
Description	Aldo-keto reductase family 1 member C3 (EC 1.-.-.-) (Trans-1,2- dihydrobenzene-1,2-diol dehydrogenase) (EC 1.3.1.20) (3-alpha- hydroxysteroid dehydrogenase type 2) (EC 1.1.1.213) (3-alpha-HSD type 2) (3-alpha-HSD type II, brain) (Prostaglandin F synthase) (EC 1.1.1.188) (PGFS) (Estradiol 17-beta-dehydrogenase) (EC 1.1.1.62) (17-beta-hydroxysteroid dehydrogenase type 5) (17-beta-HSD 5) (Chlordecone reductase homolog HAKRb) (HA1753) (Dihydrodiol dehydrogenase type I) (Dihydrodiol dehydrogenase 3) (DD3) (DD-3).

ALD1_MOUSE
NC score	0.090138 (rank : 19)	θ value	θ > 10 (rank : 33)
Query Neighborhood Hits	28	Target Neighborhood Hits	22	Shared Neighborhood Hits	11
SwissProt Accessions	P21300	Gene names	Akr1b7, Avdp
Domain Architecture
Description	Aldose reductase-related protein 1 (EC 1.1.1.21) (AR) (Aldehyde reductase) (VAS deferens androgen-dependent protein) (MVDP) (Aldo-keto reductase family 1 member B7).

AK1C4_HUMAN
NC score	0.076031 (rank : 20)	θ value	θ > 10 (rank : 29)
Query Neighborhood Hits	28	Target Neighborhood Hits	28	Shared Neighborhood Hits	14
SwissProt Accessions	P17516, Q5T6A3, Q8WW84, Q9NS54	Gene names	AKR1C4, CHDR
Domain Architecture
Description	Aldo-keto reductase family 1 member C4 (EC 1.1.1.-) (Chlordecone reductase) (EC 1.1.1.225) (CDR) (3-alpha-hydroxysteroid dehydrogenase type I) (EC 1.1.1.50) (3-alpha-HSD1) (Dihydrodiol dehydrogenase 4) (DD4) (HAKRA).

DHB5_MOUSE
NC score	0.076027 (rank : 21)	θ value	θ > 10 (rank : 35)
Query Neighborhood Hits	28	Target Neighborhood Hits	26	Shared Neighborhood Hits	14
SwissProt Accessions	P70694	Gene names	Akr1c6, Hsd17b5
Domain Architecture
Description	Estradiol 17 beta-dehydrogenase 5 (EC 1.1.1.-) (17-beta-HSD 5).

AKC1H_MOUSE
NC score	0.066256 (rank : 22)	θ value	θ > 10 (rank : 32)
Query Neighborhood Hits	28	Target Neighborhood Hits	22	Shared Neighborhood Hits	12
SwissProt Accessions	Q8K023, Q99N44	Gene names	Akr1c18
Domain Architecture	No domain graphic available
Description	Aldo-keto reductase family 1 member C18 (EC 1.1.-.-) (20-alpha- hydroxysteroid dehydrogenase) (EC 1.1.1.149) (20-alpha-HSD).

AK1D1_HUMAN
NC score	0.051484 (rank : 23)	θ value	θ > 10 (rank : 30)
Query Neighborhood Hits	28	Target Neighborhood Hits	29	Shared Neighborhood Hits	10
SwissProt Accessions	P51857	Gene names	AKR1D1, SRD5B1
Domain Architecture
Description	3-oxo-5-beta-steroid 4-dehydrogenase (EC 1.3.1.3) (Delta(4)-3- ketosteroid 5-beta-reductase) (Aldo-keto reductase family 1 member D1).

RIB2_HUMAN
NC score	0.045330 (rank : 24)	θ value	0.365318 (rank : 14)
Query Neighborhood Hits	28	Target Neighborhood Hits	9	Shared Neighborhood Hits	4
SwissProt Accessions	P04844, Q6IBA5, Q96E21, Q9BUQ3, Q9UBE1	Gene names	RPN2
Domain Architecture
Description	Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 63 kDa subunit precursor (EC 2.4.1.119) (Ribophorin II) (RPN-II) (RIBIIR).

TTC5_MOUSE
NC score	0.036911 (rank : 25)	θ value	4.03905 (rank : 23)
Query Neighborhood Hits	28	Target Neighborhood Hits	51	Shared Neighborhood Hits	5
SwissProt Accessions	Q99LG4	Gene names	Ttc5
Domain Architecture	No domain graphic available
Description	Tetratricopeptide repeat protein 5 (TPR repeat protein 5).

CO5A2_HUMAN
NC score	0.013495 (rank : 26)	θ value	0.47712 (rank : 15)
Query Neighborhood Hits	28	Target Neighborhood Hits	760	Shared Neighborhood Hits	5
SwissProt Accessions	P05997	Gene names	COL5A2
Domain Architecture
Description	Collagen alpha-2(V) chain precursor.

CO7A1_HUMAN
NC score	0.012473 (rank : 27)	θ value	0.365318 (rank : 13)
Query Neighborhood Hits	28	Target Neighborhood Hits	807	Shared Neighborhood Hits	7
SwissProt Accessions	Q02388, Q14054, Q16507	Gene names	COL7A1
Domain Architecture
Description	Collagen alpha-1(VII) chain precursor (Long-chain collagen) (LC collagen).

DPOLZ_MOUSE
NC score	0.012465 (rank : 28)	θ value	4.03905 (rank : 22)
Query Neighborhood Hits	28	Target Neighborhood Hits	169	Shared Neighborhood Hits	4
SwissProt Accessions	Q61493, Q9JMD6, Q9QWX6	Gene names	Rev3l, Polz, Sez4
Domain Architecture
Description	DNA polymerase zeta catalytic subunit (EC 2.7.7.7) (Seizure-related protein 4).

CO9A1_HUMAN
NC score	0.012412 (rank : 29)	θ value	3.0926 (rank : 21)
Query Neighborhood Hits	28	Target Neighborhood Hits	420	Shared Neighborhood Hits	5
SwissProt Accessions	P20849, Q13699, Q13700, Q5TF52, Q6P467, Q96BM8, Q99225, Q9H151, Q9H152, Q9Y6P2, Q9Y6P3	Gene names	COL9A1
Domain Architecture
Description	Collagen alpha-1(IX) chain precursor.

CO9A1_MOUSE
NC score	0.010365 (rank : 30)	θ value	8.99809 (rank : 27)
Query Neighborhood Hits	28	Target Neighborhood Hits	477	Shared Neighborhood Hits	5
SwissProt Accessions	Q05722, Q61269, Q61270, Q61433, Q61940	Gene names	Col9a1
Domain Architecture
Description	Collagen alpha-1(IX) chain precursor.

JHD2A_MOUSE
NC score	0.006884 (rank : 31)	θ value	6.88961 (rank : 26)
Query Neighborhood Hits	28	Target Neighborhood Hits	123	Shared Neighborhood Hits	2
SwissProt Accessions	Q6PCM1, Q2MJQ6, Q3TKW8, Q3UML3, Q6ZQ57, Q8K2J6, Q8K2K4, Q8R350	Gene names	Jmjd1a, Jhdm2a, Kiaa0742
Domain Architecture	No domain graphic available
Description	JmjC domain-containing histone demethylation protein 2A (EC 1.14.11.-) (Jumonji domain-containing protein 1A).

PDZD2_HUMAN
NC score	0.006588 (rank : 32)	θ value	5.27518 (rank : 24)
Query Neighborhood Hits	28	Target Neighborhood Hits	772	Shared Neighborhood Hits	4
SwissProt Accessions	O15018, Q9BXD4	Gene names	PDZD2, AIPC, KIAA0300, PDZK3
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 2 (PDZ domain-containing protein 3) (Activated in prostate cancer protein).

B4GT1_HUMAN
NC score	0.006088 (rank : 33)	θ value	6.88961 (rank : 25)
Query Neighborhood Hits	28	Target Neighborhood Hits	168	Shared Neighborhood Hits	2
SwissProt Accessions	P15291, Q12909, Q12910, Q12911, Q14456, Q14509, Q14523	Gene names	B4GALT1, GGTB2
Domain Architecture
Description	Beta-1,4-galactosyltransferase 1 (EC 2.4.1.-) (Beta-1,4-GalTase 1) (Beta4Gal-T1) (b4Gal-T1) (UDP-galactose:beta-N-acetylglucosamine beta- 1,4-galactosyltransferase 1) (UDP-Gal:beta-GlcNAc beta-1,4- galactosyltransferase 1) [Includes: Lactose synthase A protein (EC 2.4.1.22); N-acetyllactosamine synthase (EC 2.4.1.90) (Nal synthetase); Beta-N-acetylglucosaminylglycopeptide beta-1,4- galactosyltransferase (EC 2.4.1.38); Beta-N-acetylglucosaminyl- glycolipid beta-1,4-galactosyltransferase (EC 2.4.1.-)].

P2RX3_HUMAN
NC score	0.006041 (rank : 34)	θ value	8.99809 (rank : 28)
Query Neighborhood Hits	28	Target Neighborhood Hits	12	Shared Neighborhood Hits	2
SwissProt Accessions	P56373, Q9UQB6	Gene names	P2RX3
Domain Architecture
Description	P2X purinoceptor 3 (ATP receptor) (P2X3) (Purinergic receptor).

EPHA5_HUMAN
NC score	0.000476 (rank : 35)	θ value	2.36792 (rank : 18)
Query Neighborhood Hits	28	Target Neighborhood Hits	1009	Shared Neighborhood Hits	3
SwissProt Accessions	P54756	Gene names	EPHA5, EHK1, HEK7
Domain Architecture
Description	Ephrin type-A receptor 5 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EHK-1) (EPH homology kinase 1) (Receptor protein- tyrosine kinase HEK7).