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Network neighborhood for query Sequence : IRK2_MOUSE

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IRK2_MOUSE
SwissProt Accessions	P35561	Gene names	Kcnj2, Irk1
Domain Architecture
Description	Inward rectifier potassium channel 2 (Potassium channel, inwardly rectifying subfamily J member 2) (Inward rectifier K(+) channel Kir2.1).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

IRK2_HUMAN
θ value	0 (rank : 1)	NC score	0.999775 (rank : 2)
Query Neighborhood Hits	46	Target Neighborhood Hits	47	Shared Neighborhood Hits	44
SwissProt Accessions	P63252, O15110, P48049	Gene names	KCNJ2, HIRK1
Domain Architecture	No domain graphic available
Description	Inward rectifier potassium channel 2 (Potassium channel, inwardly rectifying subfamily J member 2) (Inward rectifier K(+) channel Kir2.1) (Cardiac inward rectifier potassium channel) (IRK1).

IRK2_MOUSE
θ value	0 (rank : 2)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	46	Target Neighborhood Hits	46	Shared Neighborhood Hits	46
SwissProt Accessions	P35561	Gene names	Kcnj2, Irk1
Domain Architecture
Description	Inward rectifier potassium channel 2 (Potassium channel, inwardly rectifying subfamily J member 2) (Inward rectifier K(+) channel Kir2.1).

IRK12_HUMAN
θ value	3.47146e-177 (rank : 3)	NC score	0.997906 (rank : 3)
Query Neighborhood Hits	46	Target Neighborhood Hits	31	Shared Neighborhood Hits	30
SwissProt Accessions	Q14500, O43401, Q8NG63	Gene names	KCNJ12, IRK2
Domain Architecture
Description	ATP-sensitive inward rectifier potassium channel 12 (Potassium channel, inwardly rectifying subfamily J member 12) (Inward rectifier K(+) channel Kir2.2) (IRK2).

IRK12_MOUSE
θ value	5.54228e-175 (rank : 4)	NC score	0.997778 (rank : 4)
Query Neighborhood Hits	46	Target Neighborhood Hits	36	Shared Neighborhood Hits	31
SwissProt Accessions	P52187, Q9QYF2	Gene names	Kcnj12, Irk2
Domain Architecture
Description	ATP-sensitive inward rectifier potassium channel 12 (Potassium channel, inwardly rectifying subfamily J member 12) (Inward rectifier K(+) channel Kir2.2) (IRK2).

IRKI_HUMAN
θ value	1.11932e-167 (rank : 5)	NC score	0.997672 (rank : 5)
Query Neighborhood Hits	46	Target Neighborhood Hits	33	Shared Neighborhood Hits	31
SwissProt Accessions	Q15756	Gene names	KCNJN1
Domain Architecture
Description	Inward rectifying K(+) channel negative regulator Kir2.2v.

IRK4_HUMAN
θ value	3.99958e-149 (rank : 6)	NC score	0.997312 (rank : 6)
Query Neighborhood Hits	46	Target Neighborhood Hits	39	Shared Neighborhood Hits	32
SwissProt Accessions	P48050	Gene names	KCNJ4
Domain Architecture
Description	Inward rectifier potassium channel 4 (Potassium channel, inwardly rectifying subfamily J member 4) (Inward rectifier K(+) channel Kir2.3) (Hippocampal inward rectifier) (HIR) (HRK1) (HIRK2).

IRK4_MOUSE
θ value	2.59246e-148 (rank : 7)	NC score	0.997260 (rank : 7)
Query Neighborhood Hits	46	Target Neighborhood Hits	38	Shared Neighborhood Hits	32
SwissProt Accessions	P52189	Gene names	Kcnj4, Irk3
Domain Architecture
Description	Inward rectifier potassium channel 4 (Potassium channel, inwardly rectifying subfamily J member 4) (Inward rectifier K(+) channel Kir2.3) (IRK3).

IRK14_MOUSE
θ value	3.27947e-143 (rank : 8)	NC score	0.996536 (rank : 8)
Query Neighborhood Hits	46	Target Neighborhood Hits	31	Shared Neighborhood Hits	30
SwissProt Accessions	Q8JZN3, Q8BMK3, Q8BXM0	Gene names	Kcnj14
Domain Architecture	No domain graphic available
Description	ATP-sensitive inward rectifier potassium channel 14 (Potassium channel, inwardly rectifying subfamily J member 14) (Inward rectifier K(+) channel Kir2.4) (IRK4).

IRK14_HUMAN
θ value	2.77624e-142 (rank : 9)	NC score	0.996441 (rank : 9)
Query Neighborhood Hits	46	Target Neighborhood Hits	36	Shared Neighborhood Hits	30
SwissProt Accessions	Q9UNX9	Gene names	KCNJ14
Domain Architecture	No domain graphic available
Description	ATP-sensitive inward rectifier potassium channel 14 (Potassium channel, inwardly rectifying subfamily J member 14) (Inward rectifier K(+) channel Kir2.4) (IRK4).

IRK5_HUMAN
θ value	3.78717e-107 (rank : 10)	NC score	0.989116 (rank : 13)
Query Neighborhood Hits	46	Target Neighborhood Hits	34	Shared Neighborhood Hits	31
SwissProt Accessions	P48544, Q6DK13, Q6DK14, Q92807	Gene names	KCNJ5, GIRK4
Domain Architecture
Description	G protein-activated inward rectifier potassium channel 4 (GIRK4) (Potassium channel, inwardly rectifying subfamily J member 5) (Inward rectifier K(+) channel Kir3.4) (Heart KATP channel) (KATP-1) (Cardiac inward rectifier) (CIR).

IRK6_HUMAN
θ value	1.1019e-106 (rank : 11)	NC score	0.988619 (rank : 14)
Query Neighborhood Hits	46	Target Neighborhood Hits	33	Shared Neighborhood Hits	30
SwissProt Accessions	P48051, Q53WW6	Gene names	KCNJ6, GIRK2, KATP2, KCNJ7
Domain Architecture
Description	G protein-activated inward rectifier potassium channel 2 (GIRK2) (Potassium channel, inwardly rectifying subfamily J member 6) (Inward rectifier K(+) channel Kir3.2) (KATP-2) (BIR1).

IRK9_HUMAN
θ value	1.1019e-106 (rank : 12)	NC score	0.990212 (rank : 11)
Query Neighborhood Hits	46	Target Neighborhood Hits	32	Shared Neighborhood Hits	30
SwissProt Accessions	Q92806, Q5JW75	Gene names	KCNJ9, GIRK3
Domain Architecture
Description	G protein-activated inward rectifier potassium channel 3 (GIRK3) (Potassium channel, inwardly rectifying subfamily J member 9) (Inwardly rectifier K(+) channel Kir3.3).

IRK9_MOUSE
θ value	1.43912e-106 (rank : 13)	NC score	0.990213 (rank : 10)
Query Neighborhood Hits	46	Target Neighborhood Hits	31	Shared Neighborhood Hits	30
SwissProt Accessions	P48543, Q9WUE1	Gene names	Kcnj9, Girk3
Domain Architecture
Description	G protein-activated inward rectifier potassium channel 3 (GIRK3) (Potassium channel, inwardly rectifying subfamily J member 9) (Inwardly rectifier K(+) channel Kir3.3).

IRK5_MOUSE
θ value	7.14227e-106 (rank : 14)	NC score	0.989269 (rank : 12)
Query Neighborhood Hits	46	Target Neighborhood Hits	31	Shared Neighborhood Hits	31
SwissProt Accessions	P48545, P97508	Gene names	Kcnj5, Girk4
Domain Architecture
Description	G protein-activated inward rectifier potassium channel 4 (GIRK4) (Potassium channel, inwardly rectifying subfamily J member 5) (Inward rectifier K(+) channel Kir3.4) (Heart KATP channel) (KATP-1) (Cardiac inward rectifier) (CIR).

IRK3_MOUSE
θ value	9.32813e-106 (rank : 15)	NC score	0.988300 (rank : 15)
Query Neighborhood Hits	46	Target Neighborhood Hits	34	Shared Neighborhood Hits	30
SwissProt Accessions	P63250, P35562	Gene names	Kcnj3, Girk1
Domain Architecture	No domain graphic available
Description	G protein-activated inward rectifier potassium channel 1 (GIRK1) (Potassium channel, inwardly rectifying subfamily J member 3) (Inward rectifier K(+) channel Kir3.1).

IRK6_MOUSE
θ value	9.32813e-106 (rank : 16)	NC score	0.988277 (rank : 16)
Query Neighborhood Hits	46	Target Neighborhood Hits	30	Shared Neighborhood Hits	30
SwissProt Accessions	P48542, O70290, P70216, P70306, P70307, P70308, P70309, P70454, Q9QYH5	Gene names	Kcnj6, Girk2, Kcnj7, W
Domain Architecture
Description	G protein-activated inward rectifier potassium channel 2 (GIRK2) (Potassium channel, inwardly rectifying subfamily J member 6) (Inward rectifier K(+) channel Kir3.2).

IRK3_HUMAN
θ value	4.6295e-105 (rank : 17)	NC score	0.988245 (rank : 17)
Query Neighborhood Hits	46	Target Neighborhood Hits	37	Shared Neighborhood Hits	30
SwissProt Accessions	P48549, Q8TBI0	Gene names	KCNJ3, GIRK1
Domain Architecture
Description	G protein-activated inward rectifier potassium channel 1 (GIRK1) (Potassium channel, inwardly rectifying subfamily J member 3) (Inward rectifier K(+) channel Kir3.1).

IRK8_HUMAN
θ value	2.91321e-91 (rank : 18)	NC score	0.985806 (rank : 23)
Query Neighborhood Hits	46	Target Neighborhood Hits	34	Shared Neighborhood Hits	30
SwissProt Accessions	Q15842, O00657	Gene names	KCNJ8
Domain Architecture
Description	ATP-sensitive inward rectifier potassium channel 8 (Potassium channel, inwardly rectifying subfamily J member 8) (Inwardly rectifier K(+) channel Kir6.1) (uKATP-1).

IRK11_HUMAN
θ value	1.10702e-90 (rank : 19)	NC score	0.986572 (rank : 21)
Query Neighborhood Hits	46	Target Neighborhood Hits	31	Shared Neighborhood Hits	30
SwissProt Accessions	Q14654, Q58EX3	Gene names	KCNJ11
Domain Architecture
Description	ATP-sensitive inward rectifier potassium channel 11 (Potassium channel, inwardly rectifying subfamily J member 11) (Inward rectifier K(+) channel Kir6.2) (IKATP).

IRK8_MOUSE
θ value	1.44581e-90 (rank : 20)	NC score	0.985860 (rank : 22)
Query Neighborhood Hits	46	Target Neighborhood Hits	34	Shared Neighborhood Hits	32
SwissProt Accessions	P97794	Gene names	Kcnj8
Domain Architecture
Description	ATP-sensitive inward rectifier potassium channel 8 (Potassium channel, inwardly rectifying subfamily J member 8) (Inwardly rectifier K(+) channel Kir6.1) (uKATP-1).

IRK11_MOUSE
θ value	4.20666e-90 (rank : 21)	NC score	0.986626 (rank : 20)
Query Neighborhood Hits	46	Target Neighborhood Hits	32	Shared Neighborhood Hits	30
SwissProt Accessions	Q61743, Q9QX21	Gene names	Kcnj11
Domain Architecture
Description	ATP-sensitive inward rectifier potassium channel 11 (Potassium channel, inwardly rectifying subfamily J member 11) (Inward rectifier K(+) channel Kir6.2).

IRK16_HUMAN
θ value	1.95407e-87 (rank : 22)	NC score	0.986676 (rank : 19)
Query Neighborhood Hits	46	Target Neighborhood Hits	31	Shared Neighborhood Hits	30
SwissProt Accessions	Q9NPI9	Gene names	KCNJ16
Domain Architecture
Description	Inward rectifier potassium channel 16 (Potassium channel, inwardly rectifying subfamily J member 16) (Inward rectifier K(+) channel Kir5.1).

IRK1_HUMAN
θ value	2.5521e-87 (rank : 23)	NC score	0.985527 (rank : 24)
Query Neighborhood Hits	46	Target Neighborhood Hits	31	Shared Neighborhood Hits	30
SwissProt Accessions	P48048, Q6LD67	Gene names	KCNJ1, ROMK1
Domain Architecture
Description	ATP-sensitive inward rectifier potassium channel 1 (Potassium channel, inwardly rectifying subfamily J member 1) (ATP-regulated potassium channel ROM-K) (Kir1.1).

IRK16_MOUSE
θ value	3.33315e-87 (rank : 24)	NC score	0.986803 (rank : 18)
Query Neighborhood Hits	46	Target Neighborhood Hits	31	Shared Neighborhood Hits	30
SwissProt Accessions	Q9Z307	Gene names	Kcnj16
Domain Architecture
Description	Inward rectifier potassium channel 16 (Potassium channel, inwardly rectifying subfamily J member 16) (Inward rectifier K(+) channel Kir5.1).

IRK1_MOUSE
θ value	2.64101e-84 (rank : 25)	NC score	0.985484 (rank : 25)
Query Neighborhood Hits	46	Target Neighborhood Hits	31	Shared Neighborhood Hits	30
SwissProt Accessions	O88335	Gene names	Kcnj1
Domain Architecture
Description	ATP-sensitive inward rectifier potassium channel 1 (Potassium channel, inwardly rectifying subfamily J member 1) (ATP-regulated potassium channel ROM-K) (Kir1.1).

IRK15_HUMAN
θ value	2.73936e-73 (rank : 26)	NC score	0.978588 (rank : 26)
Query Neighborhood Hits	46	Target Neighborhood Hits	35	Shared Neighborhood Hits	30
SwissProt Accessions	Q99712, O00564, Q96L28, Q99446	Gene names	KCNJ15, KCNJ14
Domain Architecture
Description	ATP-sensitive inward rectifier potassium channel 15 (Potassium channel, inwardly rectifying subfamily J member 15) (Inward rectifier K(+) channel Kir4.2) (Kir1.3).

IRK15_MOUSE
θ value	3.57772e-73 (rank : 27)	NC score	0.978581 (rank : 27)
Query Neighborhood Hits	46	Target Neighborhood Hits	36	Shared Neighborhood Hits	30
SwissProt Accessions	O88932, Q9JK34	Gene names	Kcnj15
Domain Architecture
Description	ATP-sensitive inward rectifier potassium channel 15 (Potassium channel, inwardly rectifying subfamily J member 15) (Inward rectifier K(+) channel Kir4.2).

IRK10_HUMAN
θ value	2.56397e-71 (rank : 28)	NC score	0.977442 (rank : 29)
Query Neighborhood Hits	46	Target Neighborhood Hits	40	Shared Neighborhood Hits	30
SwissProt Accessions	P78508, Q8N4I7, Q92808	Gene names	KCNJ10
Domain Architecture
Description	ATP-sensitive inward rectifier potassium channel 10 (Potassium channel, inwardly rectifying subfamily J member 10) (Inward rectifier K(+) channel Kir1.2) (ATP-dependent inwardly rectifying potassium channel Kir4.1).

IRK10_MOUSE
θ value	1.66191e-70 (rank : 29)	NC score	0.977531 (rank : 28)
Query Neighborhood Hits	46	Target Neighborhood Hits	40	Shared Neighborhood Hits	30
SwissProt Accessions	Q9JM63	Gene names	Kcnj10
Domain Architecture
Description	ATP-sensitive inward rectifier potassium channel 10 (Potassium channel, inwardly rectifying subfamily J member 10) (Inward rectifier K(+) channel Kir4.1).

IRK13_HUMAN
θ value	7.25919e-50 (rank : 30)	NC score	0.973049 (rank : 30)
Query Neighborhood Hits	46	Target Neighborhood Hits	39	Shared Neighborhood Hits	32
SwissProt Accessions	O60928, O76023, Q8N3Y4	Gene names	KCNJ13
Domain Architecture
Description	Inward rectifier potassium channel 13 (Potassium channel, inwardly rectifying subfamily J member 13) (Inward rectifier K(+) channel Kir7.1).

ANKZ1_MOUSE
θ value	0.00390308 (rank : 31)	NC score	0.047990 (rank : 31)
Query Neighborhood Hits	46	Target Neighborhood Hits	208	Shared Neighborhood Hits	6
SwissProt Accessions	Q80UU1, Q9CZF5	Gene names	Ankzf1, D1Ertd161e
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and zinc finger domain-containing protein 1.

KCND1_MOUSE
θ value	0.279714 (rank : 32)	NC score	0.021331 (rank : 33)
Query Neighborhood Hits	46	Target Neighborhood Hits	165	Shared Neighborhood Hits	12
SwissProt Accessions	Q03719, Q8CC68	Gene names	Kcnd1
Domain Architecture
Description	Potassium voltage-gated channel subfamily D member 1 (Voltage-gated potassium channel subunit Kv4.1) (mShal).

CTL5_HUMAN
θ value	0.365318 (rank : 33)	NC score	0.016765 (rank : 37)
Query Neighborhood Hits	46	Target Neighborhood Hits	16	Shared Neighborhood Hits	4
SwissProt Accessions	Q8NCS7, Q8NA44, Q8NB86	Gene names	SLC44A5, CTL5
Domain Architecture	No domain graphic available
Description	Choline transporter-like protein 5 (Solute carrier family 44 member 5).

KCND1_HUMAN
θ value	0.62314 (rank : 34)	NC score	0.020041 (rank : 34)
Query Neighborhood Hits	46	Target Neighborhood Hits	160	Shared Neighborhood Hits	12
SwissProt Accessions	Q9NSA2, O75671	Gene names	KCND1
Domain Architecture
Description	Potassium voltage-gated channel subfamily D member 1 (Voltage-gated potassium channel subunit Kv4.1).

ANKZ1_HUMAN
θ value	1.38821 (rank : 35)	NC score	0.025605 (rank : 32)
Query Neighborhood Hits	46	Target Neighborhood Hits	236	Shared Neighborhood Hits	3
SwissProt Accessions	Q9H8Y5, Q9NVZ4	Gene names	ANKZF1, ZNF744
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and zinc finger domain-containing protein 1 (Zinc finger protein 744).

KCND2_HUMAN
θ value	1.38821 (rank : 36)	NC score	0.017859 (rank : 35)
Query Neighborhood Hits	46	Target Neighborhood Hits	154	Shared Neighborhood Hits	10
SwissProt Accessions	Q9NZV8, O95012, O95021, Q9UBY7, Q9UN98, Q9UNH9	Gene names	KCND2, KIAA1044
Domain Architecture
Description	Potassium voltage-gated channel subfamily D member 2 (Voltage-gated potassium channel subunit Kv4.2).

KCND2_MOUSE
θ value	1.38821 (rank : 37)	NC score	0.017855 (rank : 36)
Query Neighborhood Hits	46	Target Neighborhood Hits	156	Shared Neighborhood Hits	10
SwissProt Accessions	Q9Z0V2, Q8BSK3, Q8CHB7, Q9JJ60	Gene names	Kcnd2, Kiaa1044
Domain Architecture
Description	Potassium voltage-gated channel subfamily D member 2 (Voltage-gated potassium channel subunit Kv4.2).

RBP2_MOUSE
θ value	2.36792 (rank : 38)	NC score	0.007025 (rank : 44)
Query Neighborhood Hits	46	Target Neighborhood Hits	232	Shared Neighborhood Hits	4
SwissProt Accessions	Q9ERU9, Q61992, Q8C9K9	Gene names	Ranbp2
Domain Architecture	No domain graphic available
Description	Ran-binding protein 2 (RanBP2).

KCNA5_MOUSE
θ value	3.0926 (rank : 39)	NC score	0.014494 (rank : 40)
Query Neighborhood Hits	46	Target Neighborhood Hits	119	Shared Neighborhood Hits	12
SwissProt Accessions	Q61762	Gene names	Kcna5
Domain Architecture
Description	Potassium voltage-gated channel subfamily A member 5 (Voltage-gated potassium channel subunit Kv1.5) (KV1-5).

KCND3_HUMAN
θ value	3.0926 (rank : 40)	NC score	0.016695 (rank : 38)
Query Neighborhood Hits	46	Target Neighborhood Hits	162	Shared Neighborhood Hits	10
SwissProt Accessions	Q9UK17, O60576, O60577, Q5T0M0, Q9UH85, Q9UH86, Q9UK16	Gene names	KCND3
Domain Architecture
Description	Potassium voltage-gated channel subfamily D member 3 (Voltage-gated potassium channel subunit Kv4.3).

KCND3_MOUSE
θ value	3.0926 (rank : 41)	NC score	0.016673 (rank : 39)
Query Neighborhood Hits	46	Target Neighborhood Hits	162	Shared Neighborhood Hits	10
SwissProt Accessions	Q9Z0V1, Q8CC44, Q9Z0V0	Gene names	Kcnd3
Domain Architecture
Description	Potassium voltage-gated channel subfamily D member 3 (Voltage-gated potassium channel subunit Kv4.3).

STAB1_MOUSE
θ value	5.27518 (rank : 42)	NC score	0.002324 (rank : 45)
Query Neighborhood Hits	46	Target Neighborhood Hits	566	Shared Neighborhood Hits	6
SwissProt Accessions	Q8R4Y4, Q8K0K6, Q8VC09	Gene names	Stab1, Feel1
Domain Architecture
Description	Stabilin-1 precursor (FEEL-1 protein).

KCNA3_MOUSE
θ value	6.88961 (rank : 43)	NC score	0.012228 (rank : 41)
Query Neighborhood Hits	46	Target Neighborhood Hits	103	Shared Neighborhood Hits	10
SwissProt Accessions	P16390	Gene names	Kcna3
Domain Architecture
Description	Potassium voltage-gated channel subfamily A member 3 (Voltage-gated potassium channel subunit Kv1.3) (MK3).

PUR8_MOUSE
θ value	6.88961 (rank : 44)	NC score	0.009506 (rank : 42)
Query Neighborhood Hits	46	Target Neighborhood Hits	7	Shared Neighborhood Hits	3
SwissProt Accessions	P54822	Gene names	Adsl, Adl
Domain Architecture
Description	Adenylosuccinate lyase (EC 4.3.2.2) (Adenylosuccinase) (ASL) (ASASE).

CTL5_MOUSE
θ value	8.99809 (rank : 45)	NC score	0.009336 (rank : 43)
Query Neighborhood Hits	46	Target Neighborhood Hits	19	Shared Neighborhood Hits	4
SwissProt Accessions	Q5RJI2	Gene names	Slc44a5, Ctl5
Domain Architecture	No domain graphic available
Description	Choline transporter-like protein 5 (Solute carrier family 44 member 5).

MST4_MOUSE
θ value	8.99809 (rank : 46)	NC score	-0.005223 (rank : 46)
Query Neighborhood Hits	46	Target Neighborhood Hits	860	Shared Neighborhood Hits	2
SwissProt Accessions	Q99JT2	Gene names	Mst4
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MST4 (EC 2.7.11.1) (STE20-like kinase MST4) (MST-4) (Mammalian STE20-like protein kinase 4).

Hits sorted by NC score

IRK2_MOUSE
NC score	0.999962 (rank : 1)	θ value	0 (rank : 2)
Query Neighborhood Hits	46	Target Neighborhood Hits	46	Shared Neighborhood Hits	46
SwissProt Accessions	P35561	Gene names	Kcnj2, Irk1
Domain Architecture
Description	Inward rectifier potassium channel 2 (Potassium channel, inwardly rectifying subfamily J member 2) (Inward rectifier K(+) channel Kir2.1).

IRK2_HUMAN
NC score	0.999775 (rank : 2)	θ value	0 (rank : 1)
Query Neighborhood Hits	46	Target Neighborhood Hits	47	Shared Neighborhood Hits	44
SwissProt Accessions	P63252, O15110, P48049	Gene names	KCNJ2, HIRK1
Domain Architecture	No domain graphic available
Description	Inward rectifier potassium channel 2 (Potassium channel, inwardly rectifying subfamily J member 2) (Inward rectifier K(+) channel Kir2.1) (Cardiac inward rectifier potassium channel) (IRK1).

IRK12_HUMAN
NC score	0.997906 (rank : 3)	θ value	3.47146e-177 (rank : 3)
Query Neighborhood Hits	46	Target Neighborhood Hits	31	Shared Neighborhood Hits	30
SwissProt Accessions	Q14500, O43401, Q8NG63	Gene names	KCNJ12, IRK2
Domain Architecture
Description	ATP-sensitive inward rectifier potassium channel 12 (Potassium channel, inwardly rectifying subfamily J member 12) (Inward rectifier K(+) channel Kir2.2) (IRK2).

IRK12_MOUSE
NC score	0.997778 (rank : 4)	θ value	5.54228e-175 (rank : 4)
Query Neighborhood Hits	46	Target Neighborhood Hits	36	Shared Neighborhood Hits	31
SwissProt Accessions	P52187, Q9QYF2	Gene names	Kcnj12, Irk2
Domain Architecture
Description	ATP-sensitive inward rectifier potassium channel 12 (Potassium channel, inwardly rectifying subfamily J member 12) (Inward rectifier K(+) channel Kir2.2) (IRK2).

IRKI_HUMAN
NC score	0.997672 (rank : 5)	θ value	1.11932e-167 (rank : 5)
Query Neighborhood Hits	46	Target Neighborhood Hits	33	Shared Neighborhood Hits	31
SwissProt Accessions	Q15756	Gene names	KCNJN1
Domain Architecture
Description	Inward rectifying K(+) channel negative regulator Kir2.2v.

IRK4_HUMAN
NC score	0.997312 (rank : 6)	θ value	3.99958e-149 (rank : 6)
Query Neighborhood Hits	46	Target Neighborhood Hits	39	Shared Neighborhood Hits	32
SwissProt Accessions	P48050	Gene names	KCNJ4
Domain Architecture
Description	Inward rectifier potassium channel 4 (Potassium channel, inwardly rectifying subfamily J member 4) (Inward rectifier K(+) channel Kir2.3) (Hippocampal inward rectifier) (HIR) (HRK1) (HIRK2).

IRK4_MOUSE
NC score	0.997260 (rank : 7)	θ value	2.59246e-148 (rank : 7)
Query Neighborhood Hits	46	Target Neighborhood Hits	38	Shared Neighborhood Hits	32
SwissProt Accessions	P52189	Gene names	Kcnj4, Irk3
Domain Architecture
Description	Inward rectifier potassium channel 4 (Potassium channel, inwardly rectifying subfamily J member 4) (Inward rectifier K(+) channel Kir2.3) (IRK3).

IRK14_MOUSE
NC score	0.996536 (rank : 8)	θ value	3.27947e-143 (rank : 8)
Query Neighborhood Hits	46	Target Neighborhood Hits	31	Shared Neighborhood Hits	30
SwissProt Accessions	Q8JZN3, Q8BMK3, Q8BXM0	Gene names	Kcnj14
Domain Architecture	No domain graphic available
Description	ATP-sensitive inward rectifier potassium channel 14 (Potassium channel, inwardly rectifying subfamily J member 14) (Inward rectifier K(+) channel Kir2.4) (IRK4).

IRK14_HUMAN
NC score	0.996441 (rank : 9)	θ value	2.77624e-142 (rank : 9)
Query Neighborhood Hits	46	Target Neighborhood Hits	36	Shared Neighborhood Hits	30
SwissProt Accessions	Q9UNX9	Gene names	KCNJ14
Domain Architecture	No domain graphic available
Description	ATP-sensitive inward rectifier potassium channel 14 (Potassium channel, inwardly rectifying subfamily J member 14) (Inward rectifier K(+) channel Kir2.4) (IRK4).

IRK9_MOUSE
NC score	0.990213 (rank : 10)	θ value	1.43912e-106 (rank : 13)
Query Neighborhood Hits	46	Target Neighborhood Hits	31	Shared Neighborhood Hits	30
SwissProt Accessions	P48543, Q9WUE1	Gene names	Kcnj9, Girk3
Domain Architecture
Description	G protein-activated inward rectifier potassium channel 3 (GIRK3) (Potassium channel, inwardly rectifying subfamily J member 9) (Inwardly rectifier K(+) channel Kir3.3).

IRK9_HUMAN
NC score	0.990212 (rank : 11)	θ value	1.1019e-106 (rank : 12)
Query Neighborhood Hits	46	Target Neighborhood Hits	32	Shared Neighborhood Hits	30
SwissProt Accessions	Q92806, Q5JW75	Gene names	KCNJ9, GIRK3
Domain Architecture
Description	G protein-activated inward rectifier potassium channel 3 (GIRK3) (Potassium channel, inwardly rectifying subfamily J member 9) (Inwardly rectifier K(+) channel Kir3.3).

IRK5_MOUSE
NC score	0.989269 (rank : 12)	θ value	7.14227e-106 (rank : 14)
Query Neighborhood Hits	46	Target Neighborhood Hits	31	Shared Neighborhood Hits	31
SwissProt Accessions	P48545, P97508	Gene names	Kcnj5, Girk4
Domain Architecture
Description	G protein-activated inward rectifier potassium channel 4 (GIRK4) (Potassium channel, inwardly rectifying subfamily J member 5) (Inward rectifier K(+) channel Kir3.4) (Heart KATP channel) (KATP-1) (Cardiac inward rectifier) (CIR).

IRK5_HUMAN
NC score	0.989116 (rank : 13)	θ value	3.78717e-107 (rank : 10)
Query Neighborhood Hits	46	Target Neighborhood Hits	34	Shared Neighborhood Hits	31
SwissProt Accessions	P48544, Q6DK13, Q6DK14, Q92807	Gene names	KCNJ5, GIRK4
Domain Architecture
Description	G protein-activated inward rectifier potassium channel 4 (GIRK4) (Potassium channel, inwardly rectifying subfamily J member 5) (Inward rectifier K(+) channel Kir3.4) (Heart KATP channel) (KATP-1) (Cardiac inward rectifier) (CIR).

IRK6_HUMAN
NC score	0.988619 (rank : 14)	θ value	1.1019e-106 (rank : 11)
Query Neighborhood Hits	46	Target Neighborhood Hits	33	Shared Neighborhood Hits	30
SwissProt Accessions	P48051, Q53WW6	Gene names	KCNJ6, GIRK2, KATP2, KCNJ7
Domain Architecture
Description	G protein-activated inward rectifier potassium channel 2 (GIRK2) (Potassium channel, inwardly rectifying subfamily J member 6) (Inward rectifier K(+) channel Kir3.2) (KATP-2) (BIR1).

IRK3_MOUSE
NC score	0.988300 (rank : 15)	θ value	9.32813e-106 (rank : 15)
Query Neighborhood Hits	46	Target Neighborhood Hits	34	Shared Neighborhood Hits	30
SwissProt Accessions	P63250, P35562	Gene names	Kcnj3, Girk1
Domain Architecture	No domain graphic available
Description	G protein-activated inward rectifier potassium channel 1 (GIRK1) (Potassium channel, inwardly rectifying subfamily J member 3) (Inward rectifier K(+) channel Kir3.1).

IRK6_MOUSE
NC score	0.988277 (rank : 16)	θ value	9.32813e-106 (rank : 16)
Query Neighborhood Hits	46	Target Neighborhood Hits	30	Shared Neighborhood Hits	30
SwissProt Accessions	P48542, O70290, P70216, P70306, P70307, P70308, P70309, P70454, Q9QYH5	Gene names	Kcnj6, Girk2, Kcnj7, W
Domain Architecture
Description	G protein-activated inward rectifier potassium channel 2 (GIRK2) (Potassium channel, inwardly rectifying subfamily J member 6) (Inward rectifier K(+) channel Kir3.2).

IRK3_HUMAN
NC score	0.988245 (rank : 17)	θ value	4.6295e-105 (rank : 17)
Query Neighborhood Hits	46	Target Neighborhood Hits	37	Shared Neighborhood Hits	30
SwissProt Accessions	P48549, Q8TBI0	Gene names	KCNJ3, GIRK1
Domain Architecture
Description	G protein-activated inward rectifier potassium channel 1 (GIRK1) (Potassium channel, inwardly rectifying subfamily J member 3) (Inward rectifier K(+) channel Kir3.1).

IRK16_MOUSE
NC score	0.986803 (rank : 18)	θ value	3.33315e-87 (rank : 24)
Query Neighborhood Hits	46	Target Neighborhood Hits	31	Shared Neighborhood Hits	30
SwissProt Accessions	Q9Z307	Gene names	Kcnj16
Domain Architecture
Description	Inward rectifier potassium channel 16 (Potassium channel, inwardly rectifying subfamily J member 16) (Inward rectifier K(+) channel Kir5.1).

IRK16_HUMAN
NC score	0.986676 (rank : 19)	θ value	1.95407e-87 (rank : 22)
Query Neighborhood Hits	46	Target Neighborhood Hits	31	Shared Neighborhood Hits	30
SwissProt Accessions	Q9NPI9	Gene names	KCNJ16
Domain Architecture
Description	Inward rectifier potassium channel 16 (Potassium channel, inwardly rectifying subfamily J member 16) (Inward rectifier K(+) channel Kir5.1).

IRK11_MOUSE
NC score	0.986626 (rank : 20)	θ value	4.20666e-90 (rank : 21)
Query Neighborhood Hits	46	Target Neighborhood Hits	32	Shared Neighborhood Hits	30
SwissProt Accessions	Q61743, Q9QX21	Gene names	Kcnj11
Domain Architecture
Description	ATP-sensitive inward rectifier potassium channel 11 (Potassium channel, inwardly rectifying subfamily J member 11) (Inward rectifier K(+) channel Kir6.2).

IRK11_HUMAN
NC score	0.986572 (rank : 21)	θ value	1.10702e-90 (rank : 19)
Query Neighborhood Hits	46	Target Neighborhood Hits	31	Shared Neighborhood Hits	30
SwissProt Accessions	Q14654, Q58EX3	Gene names	KCNJ11
Domain Architecture
Description	ATP-sensitive inward rectifier potassium channel 11 (Potassium channel, inwardly rectifying subfamily J member 11) (Inward rectifier K(+) channel Kir6.2) (IKATP).

IRK8_MOUSE
NC score	0.985860 (rank : 22)	θ value	1.44581e-90 (rank : 20)
Query Neighborhood Hits	46	Target Neighborhood Hits	34	Shared Neighborhood Hits	32
SwissProt Accessions	P97794	Gene names	Kcnj8
Domain Architecture
Description	ATP-sensitive inward rectifier potassium channel 8 (Potassium channel, inwardly rectifying subfamily J member 8) (Inwardly rectifier K(+) channel Kir6.1) (uKATP-1).

IRK8_HUMAN
NC score	0.985806 (rank : 23)	θ value	2.91321e-91 (rank : 18)
Query Neighborhood Hits	46	Target Neighborhood Hits	34	Shared Neighborhood Hits	30
SwissProt Accessions	Q15842, O00657	Gene names	KCNJ8
Domain Architecture
Description	ATP-sensitive inward rectifier potassium channel 8 (Potassium channel, inwardly rectifying subfamily J member 8) (Inwardly rectifier K(+) channel Kir6.1) (uKATP-1).

IRK1_HUMAN
NC score	0.985527 (rank : 24)	θ value	2.5521e-87 (rank : 23)
Query Neighborhood Hits	46	Target Neighborhood Hits	31	Shared Neighborhood Hits	30
SwissProt Accessions	P48048, Q6LD67	Gene names	KCNJ1, ROMK1
Domain Architecture
Description	ATP-sensitive inward rectifier potassium channel 1 (Potassium channel, inwardly rectifying subfamily J member 1) (ATP-regulated potassium channel ROM-K) (Kir1.1).

IRK1_MOUSE
NC score	0.985484 (rank : 25)	θ value	2.64101e-84 (rank : 25)
Query Neighborhood Hits	46	Target Neighborhood Hits	31	Shared Neighborhood Hits	30
SwissProt Accessions	O88335	Gene names	Kcnj1
Domain Architecture
Description	ATP-sensitive inward rectifier potassium channel 1 (Potassium channel, inwardly rectifying subfamily J member 1) (ATP-regulated potassium channel ROM-K) (Kir1.1).

IRK15_HUMAN
NC score	0.978588 (rank : 26)	θ value	2.73936e-73 (rank : 26)
Query Neighborhood Hits	46	Target Neighborhood Hits	35	Shared Neighborhood Hits	30
SwissProt Accessions	Q99712, O00564, Q96L28, Q99446	Gene names	KCNJ15, KCNJ14
Domain Architecture
Description	ATP-sensitive inward rectifier potassium channel 15 (Potassium channel, inwardly rectifying subfamily J member 15) (Inward rectifier K(+) channel Kir4.2) (Kir1.3).

IRK15_MOUSE
NC score	0.978581 (rank : 27)	θ value	3.57772e-73 (rank : 27)
Query Neighborhood Hits	46	Target Neighborhood Hits	36	Shared Neighborhood Hits	30
SwissProt Accessions	O88932, Q9JK34	Gene names	Kcnj15
Domain Architecture
Description	ATP-sensitive inward rectifier potassium channel 15 (Potassium channel, inwardly rectifying subfamily J member 15) (Inward rectifier K(+) channel Kir4.2).

IRK10_MOUSE
NC score	0.977531 (rank : 28)	θ value	1.66191e-70 (rank : 29)
Query Neighborhood Hits	46	Target Neighborhood Hits	40	Shared Neighborhood Hits	30
SwissProt Accessions	Q9JM63	Gene names	Kcnj10
Domain Architecture
Description	ATP-sensitive inward rectifier potassium channel 10 (Potassium channel, inwardly rectifying subfamily J member 10) (Inward rectifier K(+) channel Kir4.1).

IRK10_HUMAN
NC score	0.977442 (rank : 29)	θ value	2.56397e-71 (rank : 28)
Query Neighborhood Hits	46	Target Neighborhood Hits	40	Shared Neighborhood Hits	30
SwissProt Accessions	P78508, Q8N4I7, Q92808	Gene names	KCNJ10
Domain Architecture
Description	ATP-sensitive inward rectifier potassium channel 10 (Potassium channel, inwardly rectifying subfamily J member 10) (Inward rectifier K(+) channel Kir1.2) (ATP-dependent inwardly rectifying potassium channel Kir4.1).

IRK13_HUMAN
NC score	0.973049 (rank : 30)	θ value	7.25919e-50 (rank : 30)
Query Neighborhood Hits	46	Target Neighborhood Hits	39	Shared Neighborhood Hits	32
SwissProt Accessions	O60928, O76023, Q8N3Y4	Gene names	KCNJ13
Domain Architecture
Description	Inward rectifier potassium channel 13 (Potassium channel, inwardly rectifying subfamily J member 13) (Inward rectifier K(+) channel Kir7.1).

ANKZ1_MOUSE
NC score	0.047990 (rank : 31)	θ value	0.00390308 (rank : 31)
Query Neighborhood Hits	46	Target Neighborhood Hits	208	Shared Neighborhood Hits	6
SwissProt Accessions	Q80UU1, Q9CZF5	Gene names	Ankzf1, D1Ertd161e
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and zinc finger domain-containing protein 1.

ANKZ1_HUMAN
NC score	0.025605 (rank : 32)	θ value	1.38821 (rank : 35)
Query Neighborhood Hits	46	Target Neighborhood Hits	236	Shared Neighborhood Hits	3
SwissProt Accessions	Q9H8Y5, Q9NVZ4	Gene names	ANKZF1, ZNF744
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and zinc finger domain-containing protein 1 (Zinc finger protein 744).

KCND1_MOUSE
NC score	0.021331 (rank : 33)	θ value	0.279714 (rank : 32)
Query Neighborhood Hits	46	Target Neighborhood Hits	165	Shared Neighborhood Hits	12
SwissProt Accessions	Q03719, Q8CC68	Gene names	Kcnd1
Domain Architecture
Description	Potassium voltage-gated channel subfamily D member 1 (Voltage-gated potassium channel subunit Kv4.1) (mShal).

KCND1_HUMAN
NC score	0.020041 (rank : 34)	θ value	0.62314 (rank : 34)
Query Neighborhood Hits	46	Target Neighborhood Hits	160	Shared Neighborhood Hits	12
SwissProt Accessions	Q9NSA2, O75671	Gene names	KCND1
Domain Architecture
Description	Potassium voltage-gated channel subfamily D member 1 (Voltage-gated potassium channel subunit Kv4.1).

KCND2_HUMAN
NC score	0.017859 (rank : 35)	θ value	1.38821 (rank : 36)
Query Neighborhood Hits	46	Target Neighborhood Hits	154	Shared Neighborhood Hits	10
SwissProt Accessions	Q9NZV8, O95012, O95021, Q9UBY7, Q9UN98, Q9UNH9	Gene names	KCND2, KIAA1044
Domain Architecture
Description	Potassium voltage-gated channel subfamily D member 2 (Voltage-gated potassium channel subunit Kv4.2).

KCND2_MOUSE
NC score	0.017855 (rank : 36)	θ value	1.38821 (rank : 37)
Query Neighborhood Hits	46	Target Neighborhood Hits	156	Shared Neighborhood Hits	10
SwissProt Accessions	Q9Z0V2, Q8BSK3, Q8CHB7, Q9JJ60	Gene names	Kcnd2, Kiaa1044
Domain Architecture
Description	Potassium voltage-gated channel subfamily D member 2 (Voltage-gated potassium channel subunit Kv4.2).

CTL5_HUMAN
NC score	0.016765 (rank : 37)	θ value	0.365318 (rank : 33)
Query Neighborhood Hits	46	Target Neighborhood Hits	16	Shared Neighborhood Hits	4
SwissProt Accessions	Q8NCS7, Q8NA44, Q8NB86	Gene names	SLC44A5, CTL5
Domain Architecture	No domain graphic available
Description	Choline transporter-like protein 5 (Solute carrier family 44 member 5).

KCND3_HUMAN
NC score	0.016695 (rank : 38)	θ value	3.0926 (rank : 40)
Query Neighborhood Hits	46	Target Neighborhood Hits	162	Shared Neighborhood Hits	10
SwissProt Accessions	Q9UK17, O60576, O60577, Q5T0M0, Q9UH85, Q9UH86, Q9UK16	Gene names	KCND3
Domain Architecture
Description	Potassium voltage-gated channel subfamily D member 3 (Voltage-gated potassium channel subunit Kv4.3).

KCND3_MOUSE
NC score	0.016673 (rank : 39)	θ value	3.0926 (rank : 41)
Query Neighborhood Hits	46	Target Neighborhood Hits	162	Shared Neighborhood Hits	10
SwissProt Accessions	Q9Z0V1, Q8CC44, Q9Z0V0	Gene names	Kcnd3
Domain Architecture
Description	Potassium voltage-gated channel subfamily D member 3 (Voltage-gated potassium channel subunit Kv4.3).

KCNA5_MOUSE
NC score	0.014494 (rank : 40)	θ value	3.0926 (rank : 39)
Query Neighborhood Hits	46	Target Neighborhood Hits	119	Shared Neighborhood Hits	12
SwissProt Accessions	Q61762	Gene names	Kcna5
Domain Architecture
Description	Potassium voltage-gated channel subfamily A member 5 (Voltage-gated potassium channel subunit Kv1.5) (KV1-5).

KCNA3_MOUSE
NC score	0.012228 (rank : 41)	θ value	6.88961 (rank : 43)
Query Neighborhood Hits	46	Target Neighborhood Hits	103	Shared Neighborhood Hits	10
SwissProt Accessions	P16390	Gene names	Kcna3
Domain Architecture
Description	Potassium voltage-gated channel subfamily A member 3 (Voltage-gated potassium channel subunit Kv1.3) (MK3).

PUR8_MOUSE
NC score	0.009506 (rank : 42)	θ value	6.88961 (rank : 44)
Query Neighborhood Hits	46	Target Neighborhood Hits	7	Shared Neighborhood Hits	3
SwissProt Accessions	P54822	Gene names	Adsl, Adl
Domain Architecture
Description	Adenylosuccinate lyase (EC 4.3.2.2) (Adenylosuccinase) (ASL) (ASASE).

CTL5_MOUSE
NC score	0.009336 (rank : 43)	θ value	8.99809 (rank : 45)
Query Neighborhood Hits	46	Target Neighborhood Hits	19	Shared Neighborhood Hits	4
SwissProt Accessions	Q5RJI2	Gene names	Slc44a5, Ctl5
Domain Architecture	No domain graphic available
Description	Choline transporter-like protein 5 (Solute carrier family 44 member 5).

RBP2_MOUSE
NC score	0.007025 (rank : 44)	θ value	2.36792 (rank : 38)
Query Neighborhood Hits	46	Target Neighborhood Hits	232	Shared Neighborhood Hits	4
SwissProt Accessions	Q9ERU9, Q61992, Q8C9K9	Gene names	Ranbp2
Domain Architecture	No domain graphic available
Description	Ran-binding protein 2 (RanBP2).

STAB1_MOUSE
NC score	0.002324 (rank : 45)	θ value	5.27518 (rank : 42)
Query Neighborhood Hits	46	Target Neighborhood Hits	566	Shared Neighborhood Hits	6
SwissProt Accessions	Q8R4Y4, Q8K0K6, Q8VC09	Gene names	Stab1, Feel1
Domain Architecture
Description	Stabilin-1 precursor (FEEL-1 protein).

MST4_MOUSE
NC score	-0.005223 (rank : 46)	θ value	8.99809 (rank : 46)
Query Neighborhood Hits	46	Target Neighborhood Hits	860	Shared Neighborhood Hits	2
SwissProt Accessions	Q99JT2	Gene names	Mst4
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MST4 (EC 2.7.11.1) (STE20-like kinase MST4) (MST-4) (Mammalian STE20-like protein kinase 4).