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Network neighborhood for query Sequence : IP6K2_HUMAN

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IP6K2_HUMAN
SwissProt Accessions	Q9UHH9, Q6P0N8, Q9BSZ6, Q9BUW3, Q9H4P7, Q9NT63, Q9UFU6	Gene names	IHPK2, IP6K2
Domain Architecture	No domain graphic available
Description	Inositol hexakisphosphate kinase 2 (EC 2.7.4.21) (InsP6 kinase 2) (Inositol hexakisphosphate kinase 2) (P(i)-uptake stimulator) (PiUS).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

IP6K2_HUMAN
θ value	0 (rank : 1)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	20	Target Neighborhood Hits	20	Shared Neighborhood Hits	20
SwissProt Accessions	Q9UHH9, Q6P0N8, Q9BSZ6, Q9BUW3, Q9H4P7, Q9NT63, Q9UFU6	Gene names	IHPK2, IP6K2
Domain Architecture	No domain graphic available
Description	Inositol hexakisphosphate kinase 2 (EC 2.7.4.21) (InsP6 kinase 2) (Inositol hexakisphosphate kinase 2) (P(i)-uptake stimulator) (PiUS).

IP6K2_MOUSE
θ value	0 (rank : 2)	NC score	0.997722 (rank : 2)
Query Neighborhood Hits	20	Target Neighborhood Hits	29	Shared Neighborhood Hits	18
SwissProt Accessions	Q80V72	Gene names	Ihpk2, Ip6k2
Domain Architecture	No domain graphic available
Description	Inositol hexakisphosphate kinase 2 (EC 2.7.4.21) (InsP6 kinase 2) (Inositol hexakisphosphate kinase 2) (P(i)-uptake stimulator) (PiUS).

IP6K1_MOUSE
θ value	1.87955e-106 (rank : 3)	NC score	0.975376 (rank : 3)
Query Neighborhood Hits	20	Target Neighborhood Hits	16	Shared Neighborhood Hits	10
SwissProt Accessions	Q6PD10, Q9QXV6	Gene names	Ihpk1, Ip6k1
Domain Architecture	No domain graphic available
Description	Inositol hexaphosphate kinase 1 (EC 2.7.4.21) (InsP6 kinase 1) (Inositol hexakisphosphate kinase 1).

IP6K1_HUMAN
θ value	3.54468e-105 (rank : 4)	NC score	0.974549 (rank : 4)
Query Neighborhood Hits	20	Target Neighborhood Hits	20	Shared Neighborhood Hits	10
SwissProt Accessions	Q92551, Q7L3I7, Q96E38	Gene names	IHPK1, IP6K1, KIAA0263
Domain Architecture	No domain graphic available
Description	Inositol hexaphosphate kinase 1 (EC 2.7.4.21) (InsP6 kinase 1) (Inositol hexakisphosphate kinase 1).

IP6K3_HUMAN
θ value	6.7005e-96 (rank : 5)	NC score	0.971842 (rank : 5)
Query Neighborhood Hits	20	Target Neighborhood Hits	19	Shared Neighborhood Hits	11
SwissProt Accessions	Q96PC2, Q96MQ9	Gene names	IHPK3, IP6K3
Domain Architecture	No domain graphic available
Description	Inositol hexaphosphate kinase 3 (EC 2.7.4.21) (InsP6 kinase 3) (Inositol hexakisphosphate kinase 3).

IP6K3_MOUSE
θ value	1.95407e-87 (rank : 6)	NC score	0.970599 (rank : 6)
Query Neighborhood Hits	20	Target Neighborhood Hits	18	Shared Neighborhood Hits	11
SwissProt Accessions	Q8BWD2	Gene names	Ihpk3, Ip6k3
Domain Architecture	No domain graphic available
Description	Inositol hexaphosphate kinase 3 (EC 2.7.4.21) (InsP6 kinase 3) (Inositol hexakisphosphate kinase 3).

IPMK_MOUSE
θ value	7.82807e-20 (rank : 7)	NC score	0.721718 (rank : 7)
Query Neighborhood Hits	20	Target Neighborhood Hits	17	Shared Neighborhood Hits	11
SwissProt Accessions	Q7TT16, Q8BZ11, Q8BZA8, Q9CWM9	Gene names	Ipmk, Impk
Domain Architecture	No domain graphic available
Description	Inositol polyphosphate multikinase (EC 2.7.1.151) (Inositol 1,3,4,6- tetrakisphosphate 5-kinase).

IPMK_HUMAN
θ value	1.74391e-19 (rank : 8)	NC score	0.710800 (rank : 8)
Query Neighborhood Hits	20	Target Neighborhood Hits	35	Shared Neighborhood Hits	11
SwissProt Accessions	Q8NFU5	Gene names	IPMK, IMPK
Domain Architecture	No domain graphic available
Description	Inositol polyphosphate multikinase (EC 2.7.1.151) (Inositol 1,3,4,6- tetrakisphosphate 5-kinase).

IP3KB_HUMAN
θ value	0.00298849 (rank : 9)	NC score	0.144439 (rank : 9)
Query Neighborhood Hits	20	Target Neighborhood Hits	124	Shared Neighborhood Hits	9
SwissProt Accessions	P27987, Q5VWL9, Q5VWM0, Q96BZ2, Q96JS1, Q9UH47	Gene names	ITPKB
Domain Architecture
Description	Inositol-trisphosphate 3-kinase B (EC 2.7.1.127) (Inositol 1,4,5- trisphosphate 3-kinase B) (IP3K B) (IP3 3-kinase B) (IP3K-B).

TRHY_HUMAN
θ value	0.47712 (rank : 10)	NC score	0.012941 (rank : 16)
Query Neighborhood Hits	20	Target Neighborhood Hits	1385	Shared Neighborhood Hits	9
SwissProt Accessions	Q07283	Gene names	THH, THL, TRHY
Domain Architecture
Description	Trichohyalin.

ANR11_HUMAN
θ value	0.813845 (rank : 11)	NC score	0.020634 (rank : 13)
Query Neighborhood Hits	20	Target Neighborhood Hits	1289	Shared Neighborhood Hits	8
SwissProt Accessions	Q6UB99, Q6NTG1, Q6QMF8	Gene names	ANKRD11, ANCO1
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 11 (Ankyrin repeat-containing cofactor 1).

SYNE1_HUMAN
θ value	1.81305 (rank : 12)	NC score	0.010750 (rank : 17)
Query Neighborhood Hits	20	Target Neighborhood Hits	1484	Shared Neighborhood Hits	8
SwissProt Accessions	Q8NF91, O94890, Q5JV19, Q5JV22, Q8N9P7, Q8TCP1, Q8WWW6, Q8WWW7, Q8WXF6, Q96N17, Q9C0A7, Q9H525, Q9H526, Q9NS36, Q9NU50, Q9UJ06, Q9UJ07, Q9ULF8	Gene names	SYNE1, KIAA0796, KIAA1262, KIAA1756, MYNE1
Domain Architecture
Description	Nesprin-1 (Nuclear envelope spectrin repeat protein 1) (Synaptic nuclear envelope protein 1) (Syne-1) (Myocyte nuclear envelope protein 1) (Myne-1) (Enaptin).

IP3KA_HUMAN
θ value	2.36792 (rank : 13)	NC score	0.094266 (rank : 11)
Query Neighborhood Hits	20	Target Neighborhood Hits	60	Shared Neighborhood Hits	12
SwissProt Accessions	P23677, Q8TAN3	Gene names	ITPKA
Domain Architecture
Description	Inositol-trisphosphate 3-kinase A (EC 2.7.1.127) (Inositol 1,4,5- trisphosphate 3-kinase A) (IP3K A) (IP3 3-kinase A).

RENT2_HUMAN
θ value	4.03905 (rank : 14)	NC score	0.013818 (rank : 15)
Query Neighborhood Hits	20	Target Neighborhood Hits	618	Shared Neighborhood Hits	4
SwissProt Accessions	Q9HAU5, Q8N8U1, Q9H1J2, Q9NWL1, Q9P2D9, Q9Y4M9	Gene names	UPF2, KIAA1408, RENT2
Domain Architecture	No domain graphic available
Description	Regulator of nonsense transcripts 2 (Nonsense mRNA reducing factor 2) (Up-frameshift suppressor 2 homolog) (hUpf2).

SPG16_MOUSE
θ value	4.03905 (rank : 15)	NC score	0.007767 (rank : 19)
Query Neighborhood Hits	20	Target Neighborhood Hits	377	Shared Neighborhood Hits	5
SwissProt Accessions	Q8K450, Q8C450, Q9CPU8, Q9D522	Gene names	Spag16, Pf20
Domain Architecture	No domain graphic available
Description	Sperm-associated antigen 16 protein (PF20 protein homolog).

TRIPB_HUMAN
θ value	4.03905 (rank : 16)	NC score	0.008648 (rank : 18)
Query Neighborhood Hits	20	Target Neighborhood Hits	1587	Shared Neighborhood Hits	10
SwissProt Accessions	Q15643, O14689, O15154, O95949	Gene names	TRIP11, CEV14
Domain Architecture	No domain graphic available
Description	Thyroid receptor-interacting protein 11 (TRIP-11) (Golgi-associated microtubule-binding protein 210) (GMAP-210) (Trip230) (Clonal evolution-related gene on chromosome 14).

IP3KA_MOUSE
θ value	5.27518 (rank : 17)	NC score	0.094379 (rank : 10)
Query Neighborhood Hits	20	Target Neighborhood Hits	29	Shared Neighborhood Hits	12
SwissProt Accessions	Q8R071	Gene names	Itpka
Domain Architecture	No domain graphic available
Description	Inositol-trisphosphate 3-kinase A (EC 2.7.1.127) (Inositol 1,4,5- trisphosphate 3-kinase A) (IP3K A) (IP3 3-kinase A).

CHD3_HUMAN
θ value	6.88961 (rank : 18)	NC score	0.006869 (rank : 20)
Query Neighborhood Hits	20	Target Neighborhood Hits	397	Shared Neighborhood Hits	5
SwissProt Accessions	Q12873, Q9Y4I0	Gene names	CHD3
Domain Architecture
Description	Chromodomain helicase-DNA-binding protein 3 (EC 3.6.1.-) (ATP- dependent helicase CHD3) (CHD-3) (Mi-2 autoantigen 240 kDa protein) (Mi2-alpha) (Zinc-finger helicase) (hZFH).

OTUB2_HUMAN
θ value	8.99809 (rank : 19)	NC score	0.016158 (rank : 14)
Query Neighborhood Hits	20	Target Neighborhood Hits	9	Shared Neighborhood Hits	3
SwissProt Accessions	Q96DC9, Q9H6T1	Gene names	OTUB2, C14orf137, OTB2, OTU2
Domain Architecture	No domain graphic available
Description	Ubiquitin thioesterase protein OTUB2 (EC 3.4.-.-) (Otubain-2) (OTU domain-containing ubiquitin aldehyde-binding protein 2) (Ubiquitin- specific-processing protease OTUB2) (Deubiquitinating enzyme OTUB2).

PLCB1_MOUSE
θ value	8.99809 (rank : 20)	NC score	0.005128 (rank : 21)
Query Neighborhood Hits	20	Target Neighborhood Hits	531	Shared Neighborhood Hits	5
SwissProt Accessions	Q9Z1B3, Q62075, Q8K5A5, Q8K5A6, Q9Z0E5, Q9Z2T5	Gene names	Plcb1, Plcb
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta 1 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (Phospholipase C- beta-1) (PLC-beta-1) (PLC-I) (PLC-154).

IP3KC_HUMAN
θ value	θ > 10 (rank : 21)	NC score	0.050071 (rank : 12)
Query Neighborhood Hits	20	Target Neighborhood Hits	50	Shared Neighborhood Hits	6
SwissProt Accessions	Q96DU7, Q9UE25, Q9Y475	Gene names	ITPKC, IP3KC
Domain Architecture	No domain graphic available
Description	Inositol-trisphosphate 3-kinase C (EC 2.7.1.127) (Inositol 1,4,5- trisphosphate 3-kinase C) (InsP 3-kinase C) (IP3K-C).

Hits sorted by NC score

IP6K2_HUMAN
NC score	0.999962 (rank : 1)	θ value	0 (rank : 1)
Query Neighborhood Hits	20	Target Neighborhood Hits	20	Shared Neighborhood Hits	20
SwissProt Accessions	Q9UHH9, Q6P0N8, Q9BSZ6, Q9BUW3, Q9H4P7, Q9NT63, Q9UFU6	Gene names	IHPK2, IP6K2
Domain Architecture	No domain graphic available
Description	Inositol hexakisphosphate kinase 2 (EC 2.7.4.21) (InsP6 kinase 2) (Inositol hexakisphosphate kinase 2) (P(i)-uptake stimulator) (PiUS).

IP6K2_MOUSE
NC score	0.997722 (rank : 2)	θ value	0 (rank : 2)
Query Neighborhood Hits	20	Target Neighborhood Hits	29	Shared Neighborhood Hits	18
SwissProt Accessions	Q80V72	Gene names	Ihpk2, Ip6k2
Domain Architecture	No domain graphic available
Description	Inositol hexakisphosphate kinase 2 (EC 2.7.4.21) (InsP6 kinase 2) (Inositol hexakisphosphate kinase 2) (P(i)-uptake stimulator) (PiUS).

IP6K1_MOUSE
NC score	0.975376 (rank : 3)	θ value	1.87955e-106 (rank : 3)
Query Neighborhood Hits	20	Target Neighborhood Hits	16	Shared Neighborhood Hits	10
SwissProt Accessions	Q6PD10, Q9QXV6	Gene names	Ihpk1, Ip6k1
Domain Architecture	No domain graphic available
Description	Inositol hexaphosphate kinase 1 (EC 2.7.4.21) (InsP6 kinase 1) (Inositol hexakisphosphate kinase 1).

IP6K1_HUMAN
NC score	0.974549 (rank : 4)	θ value	3.54468e-105 (rank : 4)
Query Neighborhood Hits	20	Target Neighborhood Hits	20	Shared Neighborhood Hits	10
SwissProt Accessions	Q92551, Q7L3I7, Q96E38	Gene names	IHPK1, IP6K1, KIAA0263
Domain Architecture	No domain graphic available
Description	Inositol hexaphosphate kinase 1 (EC 2.7.4.21) (InsP6 kinase 1) (Inositol hexakisphosphate kinase 1).

IP6K3_HUMAN
NC score	0.971842 (rank : 5)	θ value	6.7005e-96 (rank : 5)
Query Neighborhood Hits	20	Target Neighborhood Hits	19	Shared Neighborhood Hits	11
SwissProt Accessions	Q96PC2, Q96MQ9	Gene names	IHPK3, IP6K3
Domain Architecture	No domain graphic available
Description	Inositol hexaphosphate kinase 3 (EC 2.7.4.21) (InsP6 kinase 3) (Inositol hexakisphosphate kinase 3).

IP6K3_MOUSE
NC score	0.970599 (rank : 6)	θ value	1.95407e-87 (rank : 6)
Query Neighborhood Hits	20	Target Neighborhood Hits	18	Shared Neighborhood Hits	11
SwissProt Accessions	Q8BWD2	Gene names	Ihpk3, Ip6k3
Domain Architecture	No domain graphic available
Description	Inositol hexaphosphate kinase 3 (EC 2.7.4.21) (InsP6 kinase 3) (Inositol hexakisphosphate kinase 3).

IPMK_MOUSE
NC score	0.721718 (rank : 7)	θ value	7.82807e-20 (rank : 7)
Query Neighborhood Hits	20	Target Neighborhood Hits	17	Shared Neighborhood Hits	11
SwissProt Accessions	Q7TT16, Q8BZ11, Q8BZA8, Q9CWM9	Gene names	Ipmk, Impk
Domain Architecture	No domain graphic available
Description	Inositol polyphosphate multikinase (EC 2.7.1.151) (Inositol 1,3,4,6- tetrakisphosphate 5-kinase).

IPMK_HUMAN
NC score	0.710800 (rank : 8)	θ value	1.74391e-19 (rank : 8)
Query Neighborhood Hits	20	Target Neighborhood Hits	35	Shared Neighborhood Hits	11
SwissProt Accessions	Q8NFU5	Gene names	IPMK, IMPK
Domain Architecture	No domain graphic available
Description	Inositol polyphosphate multikinase (EC 2.7.1.151) (Inositol 1,3,4,6- tetrakisphosphate 5-kinase).

IP3KB_HUMAN
NC score	0.144439 (rank : 9)	θ value	0.00298849 (rank : 9)
Query Neighborhood Hits	20	Target Neighborhood Hits	124	Shared Neighborhood Hits	9
SwissProt Accessions	P27987, Q5VWL9, Q5VWM0, Q96BZ2, Q96JS1, Q9UH47	Gene names	ITPKB
Domain Architecture
Description	Inositol-trisphosphate 3-kinase B (EC 2.7.1.127) (Inositol 1,4,5- trisphosphate 3-kinase B) (IP3K B) (IP3 3-kinase B) (IP3K-B).

IP3KA_MOUSE
NC score	0.094379 (rank : 10)	θ value	5.27518 (rank : 17)
Query Neighborhood Hits	20	Target Neighborhood Hits	29	Shared Neighborhood Hits	12
SwissProt Accessions	Q8R071	Gene names	Itpka
Domain Architecture	No domain graphic available
Description	Inositol-trisphosphate 3-kinase A (EC 2.7.1.127) (Inositol 1,4,5- trisphosphate 3-kinase A) (IP3K A) (IP3 3-kinase A).

IP3KA_HUMAN
NC score	0.094266 (rank : 11)	θ value	2.36792 (rank : 13)
Query Neighborhood Hits	20	Target Neighborhood Hits	60	Shared Neighborhood Hits	12
SwissProt Accessions	P23677, Q8TAN3	Gene names	ITPKA
Domain Architecture
Description	Inositol-trisphosphate 3-kinase A (EC 2.7.1.127) (Inositol 1,4,5- trisphosphate 3-kinase A) (IP3K A) (IP3 3-kinase A).

IP3KC_HUMAN
NC score	0.050071 (rank : 12)	θ value	θ > 10 (rank : 21)
Query Neighborhood Hits	20	Target Neighborhood Hits	50	Shared Neighborhood Hits	6
SwissProt Accessions	Q96DU7, Q9UE25, Q9Y475	Gene names	ITPKC, IP3KC
Domain Architecture	No domain graphic available
Description	Inositol-trisphosphate 3-kinase C (EC 2.7.1.127) (Inositol 1,4,5- trisphosphate 3-kinase C) (InsP 3-kinase C) (IP3K-C).

ANR11_HUMAN
NC score	0.020634 (rank : 13)	θ value	0.813845 (rank : 11)
Query Neighborhood Hits	20	Target Neighborhood Hits	1289	Shared Neighborhood Hits	8
SwissProt Accessions	Q6UB99, Q6NTG1, Q6QMF8	Gene names	ANKRD11, ANCO1
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 11 (Ankyrin repeat-containing cofactor 1).

OTUB2_HUMAN
NC score	0.016158 (rank : 14)	θ value	8.99809 (rank : 19)
Query Neighborhood Hits	20	Target Neighborhood Hits	9	Shared Neighborhood Hits	3
SwissProt Accessions	Q96DC9, Q9H6T1	Gene names	OTUB2, C14orf137, OTB2, OTU2
Domain Architecture	No domain graphic available
Description	Ubiquitin thioesterase protein OTUB2 (EC 3.4.-.-) (Otubain-2) (OTU domain-containing ubiquitin aldehyde-binding protein 2) (Ubiquitin- specific-processing protease OTUB2) (Deubiquitinating enzyme OTUB2).

RENT2_HUMAN
NC score	0.013818 (rank : 15)	θ value	4.03905 (rank : 14)
Query Neighborhood Hits	20	Target Neighborhood Hits	618	Shared Neighborhood Hits	4
SwissProt Accessions	Q9HAU5, Q8N8U1, Q9H1J2, Q9NWL1, Q9P2D9, Q9Y4M9	Gene names	UPF2, KIAA1408, RENT2
Domain Architecture	No domain graphic available
Description	Regulator of nonsense transcripts 2 (Nonsense mRNA reducing factor 2) (Up-frameshift suppressor 2 homolog) (hUpf2).

TRHY_HUMAN
NC score	0.012941 (rank : 16)	θ value	0.47712 (rank : 10)
Query Neighborhood Hits	20	Target Neighborhood Hits	1385	Shared Neighborhood Hits	9
SwissProt Accessions	Q07283	Gene names	THH, THL, TRHY
Domain Architecture
Description	Trichohyalin.

SYNE1_HUMAN
NC score	0.010750 (rank : 17)	θ value	1.81305 (rank : 12)
Query Neighborhood Hits	20	Target Neighborhood Hits	1484	Shared Neighborhood Hits	8
SwissProt Accessions	Q8NF91, O94890, Q5JV19, Q5JV22, Q8N9P7, Q8TCP1, Q8WWW6, Q8WWW7, Q8WXF6, Q96N17, Q9C0A7, Q9H525, Q9H526, Q9NS36, Q9NU50, Q9UJ06, Q9UJ07, Q9ULF8	Gene names	SYNE1, KIAA0796, KIAA1262, KIAA1756, MYNE1
Domain Architecture
Description	Nesprin-1 (Nuclear envelope spectrin repeat protein 1) (Synaptic nuclear envelope protein 1) (Syne-1) (Myocyte nuclear envelope protein 1) (Myne-1) (Enaptin).

TRIPB_HUMAN
NC score	0.008648 (rank : 18)	θ value	4.03905 (rank : 16)
Query Neighborhood Hits	20	Target Neighborhood Hits	1587	Shared Neighborhood Hits	10
SwissProt Accessions	Q15643, O14689, O15154, O95949	Gene names	TRIP11, CEV14
Domain Architecture	No domain graphic available
Description	Thyroid receptor-interacting protein 11 (TRIP-11) (Golgi-associated microtubule-binding protein 210) (GMAP-210) (Trip230) (Clonal evolution-related gene on chromosome 14).

SPG16_MOUSE
NC score	0.007767 (rank : 19)	θ value	4.03905 (rank : 15)
Query Neighborhood Hits	20	Target Neighborhood Hits	377	Shared Neighborhood Hits	5
SwissProt Accessions	Q8K450, Q8C450, Q9CPU8, Q9D522	Gene names	Spag16, Pf20
Domain Architecture	No domain graphic available
Description	Sperm-associated antigen 16 protein (PF20 protein homolog).

CHD3_HUMAN
NC score	0.006869 (rank : 20)	θ value	6.88961 (rank : 18)
Query Neighborhood Hits	20	Target Neighborhood Hits	397	Shared Neighborhood Hits	5
SwissProt Accessions	Q12873, Q9Y4I0	Gene names	CHD3
Domain Architecture
Description	Chromodomain helicase-DNA-binding protein 3 (EC 3.6.1.-) (ATP- dependent helicase CHD3) (CHD-3) (Mi-2 autoantigen 240 kDa protein) (Mi2-alpha) (Zinc-finger helicase) (hZFH).

PLCB1_MOUSE
NC score	0.005128 (rank : 21)	θ value	8.99809 (rank : 20)
Query Neighborhood Hits	20	Target Neighborhood Hits	531	Shared Neighborhood Hits	5
SwissProt Accessions	Q9Z1B3, Q62075, Q8K5A5, Q8K5A6, Q9Z0E5, Q9Z2T5	Gene names	Plcb1, Plcb
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta 1 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (Phospholipase C- beta-1) (PLC-beta-1) (PLC-I) (PLC-154).