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Network neighborhood for query Sequence : INMT_HUMAN

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INMT_HUMAN
SwissProt Accessions	O95050, Q3KP49, Q9P1Y2, Q9UBY4, Q9UHQ0	Gene names	INMT
Domain Architecture
Description	Indolethylamine N-methyltransferase (EC 2.1.1.49) (Aromatic alkylamine N-methyltransferase) (Indolamine N-methyltransferase) (Arylamine N- methyltransferase) (Amine N-methyltransferase).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

INMT_HUMAN
θ value	4.87785e-155 (rank : 1)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	9	Target Neighborhood Hits	9	Shared Neighborhood Hits	9
SwissProt Accessions	O95050, Q3KP49, Q9P1Y2, Q9UBY4, Q9UHQ0	Gene names	INMT
Domain Architecture
Description	Indolethylamine N-methyltransferase (EC 2.1.1.49) (Aromatic alkylamine N-methyltransferase) (Indolamine N-methyltransferase) (Arylamine N- methyltransferase) (Amine N-methyltransferase).

INMT_MOUSE
θ value	1.00358e-83 (rank : 2)	NC score	0.990935 (rank : 2)
Query Neighborhood Hits	9	Target Neighborhood Hits	8	Shared Neighborhood Hits	7
SwissProt Accessions	P40936, Q9CZ50	Gene names	Inmt, Temt
Domain Architecture
Description	Indolethylamine N-methyltransferase (EC 2.1.1.49) (Aromatic alkylamine N-methyltransferase) (Indolamine N-methyltransferase) (Arylamine N- methyltransferase) (Amine N-methyltransferase).

NNMT_HUMAN
θ value	6.7473e-72 (rank : 3)	NC score	0.978467 (rank : 4)
Query Neighborhood Hits	9	Target Neighborhood Hits	11	Shared Neighborhood Hits	7
SwissProt Accessions	P40261	Gene names	NNMT
Domain Architecture
Description	Nicotinamide N-methyltransferase (EC 2.1.1.1).

NNMT_MOUSE
θ value	3.34864e-71 (rank : 4)	NC score	0.978988 (rank : 3)
Query Neighborhood Hits	9	Target Neighborhood Hits	11	Shared Neighborhood Hits	6
SwissProt Accessions	O55239	Gene names	Nnmt
Domain Architecture
Description	Nicotinamide N-methyltransferase (EC 2.1.1.1).

PNMT_HUMAN
θ value	2.04573e-44 (rank : 5)	NC score	0.928252 (rank : 5)
Query Neighborhood Hits	9	Target Neighborhood Hits	14	Shared Neighborhood Hits	6
SwissProt Accessions	P11086	Gene names	PNMT, PENT
Domain Architecture
Description	Phenylethanolamine N-methyltransferase (EC 2.1.1.28) (PNMTase) (Noradrenaline N-methyltransferase).

PNMT_MOUSE
θ value	4.55743e-44 (rank : 6)	NC score	0.928115 (rank : 6)
Query Neighborhood Hits	9	Target Neighborhood Hits	14	Shared Neighborhood Hits	6
SwissProt Accessions	P40935	Gene names	Pnmt
Domain Architecture
Description	Phenylethanolamine N-methyltransferase (EC 2.1.1.28) (PNMTase) (Noradrenaline N-methyltransferase).

FAS_HUMAN
θ value	6.88961 (rank : 8)	NC score	0.019294 (rank : 8)
Query Neighborhood Hits	9	Target Neighborhood Hits	66	Shared Neighborhood Hits	3
SwissProt Accessions	P49327, Q13479, Q16702, Q6P4U5, Q6SS02, Q969R1, Q96C68, Q96IT0	Gene names	FASN, FAS
Domain Architecture
Description	Fatty acid synthase (EC 2.3.1.85) [Includes: [Acyl-carrier-protein] S- acetyltransferase (EC 2.3.1.38); [Acyl-carrier-protein] S- malonyltransferase (EC 2.3.1.39); 3-oxoacyl-[acyl-carrier-protein] synthase (EC 2.3.1.41); 3-oxoacyl-[acyl-carrier-protein] reductase (EC 1.1.1.100); 3-hydroxypalmitoyl-[acyl-carrier-protein] dehydratase (EC 4.2.1.61); Enoyl-[acyl-carrier-protein] reductase (EC 1.3.1.10); Oleoyl-[acyl-carrier-protein] hydrolase (EC 3.1.2.14)].

Hits sorted by NC score

INMT_HUMAN
NC score	0.999962 (rank : 1)	θ value	4.87785e-155 (rank : 1)
Query Neighborhood Hits	9	Target Neighborhood Hits	9	Shared Neighborhood Hits	9
SwissProt Accessions	O95050, Q3KP49, Q9P1Y2, Q9UBY4, Q9UHQ0	Gene names	INMT
Domain Architecture
Description	Indolethylamine N-methyltransferase (EC 2.1.1.49) (Aromatic alkylamine N-methyltransferase) (Indolamine N-methyltransferase) (Arylamine N- methyltransferase) (Amine N-methyltransferase).

INMT_MOUSE
NC score	0.990935 (rank : 2)	θ value	1.00358e-83 (rank : 2)
Query Neighborhood Hits	9	Target Neighborhood Hits	8	Shared Neighborhood Hits	7
SwissProt Accessions	P40936, Q9CZ50	Gene names	Inmt, Temt
Domain Architecture
Description	Indolethylamine N-methyltransferase (EC 2.1.1.49) (Aromatic alkylamine N-methyltransferase) (Indolamine N-methyltransferase) (Arylamine N- methyltransferase) (Amine N-methyltransferase).

NNMT_MOUSE
NC score	0.978988 (rank : 3)	θ value	3.34864e-71 (rank : 4)
Query Neighborhood Hits	9	Target Neighborhood Hits	11	Shared Neighborhood Hits	6
SwissProt Accessions	O55239	Gene names	Nnmt
Domain Architecture
Description	Nicotinamide N-methyltransferase (EC 2.1.1.1).

NNMT_HUMAN
NC score	0.978467 (rank : 4)	θ value	6.7473e-72 (rank : 3)
Query Neighborhood Hits	9	Target Neighborhood Hits	11	Shared Neighborhood Hits	7
SwissProt Accessions	P40261	Gene names	NNMT
Domain Architecture
Description	Nicotinamide N-methyltransferase (EC 2.1.1.1).

PNMT_HUMAN
NC score	0.928252 (rank : 5)	θ value	2.04573e-44 (rank : 5)
Query Neighborhood Hits	9	Target Neighborhood Hits	14	Shared Neighborhood Hits	6
SwissProt Accessions	P11086	Gene names	PNMT, PENT
Domain Architecture
Description	Phenylethanolamine N-methyltransferase (EC 2.1.1.28) (PNMTase) (Noradrenaline N-methyltransferase).

PNMT_MOUSE
NC score	0.928115 (rank : 6)	θ value	4.55743e-44 (rank : 6)
Query Neighborhood Hits	9	Target Neighborhood Hits	14	Shared Neighborhood Hits	6
SwissProt Accessions	P40935	Gene names	Pnmt
Domain Architecture
Description	Phenylethanolamine N-methyltransferase (EC 2.1.1.28) (PNMTase) (Noradrenaline N-methyltransferase).

FAS_HUMAN
NC score	0.019294 (rank : 8)	θ value	6.88961 (rank : 8)
Query Neighborhood Hits	9	Target Neighborhood Hits	66	Shared Neighborhood Hits	3
SwissProt Accessions	P49327, Q13479, Q16702, Q6P4U5, Q6SS02, Q969R1, Q96C68, Q96IT0	Gene names	FASN, FAS
Domain Architecture
Description	Fatty acid synthase (EC 2.3.1.85) [Includes: [Acyl-carrier-protein] S- acetyltransferase (EC 2.3.1.38); [Acyl-carrier-protein] S- malonyltransferase (EC 2.3.1.39); 3-oxoacyl-[acyl-carrier-protein] synthase (EC 2.3.1.41); 3-oxoacyl-[acyl-carrier-protein] reductase (EC 1.1.1.100); 3-hydroxypalmitoyl-[acyl-carrier-protein] dehydratase (EC 4.2.1.61); Enoyl-[acyl-carrier-protein] reductase (EC 1.3.1.10); Oleoyl-[acyl-carrier-protein] hydrolase (EC 3.1.2.14)].