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Network neighborhood for query Sequence : ERCC2_HUMAN

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ERCC2_HUMAN
SwissProt Accessions	P18074, Q8N721	Gene names	ERCC2, XPD, XPDC
Domain Architecture
Description	TFIIH basal transcription factor complex helicase subunit (EC 3.6.1.-) (DNA-repair protein complementing XP-D cells) (Xeroderma pigmentosum group D-complementing protein) (CXPD) (DNA excision repair protein ERCC-2).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

ERCC2_HUMAN
θ value	0 (rank : 1)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	21	Target Neighborhood Hits	21	Shared Neighborhood Hits	21
SwissProt Accessions	P18074, Q8N721	Gene names	ERCC2, XPD, XPDC
Domain Architecture
Description	TFIIH basal transcription factor complex helicase subunit (EC 3.6.1.-) (DNA-repair protein complementing XP-D cells) (Xeroderma pigmentosum group D-complementing protein) (CXPD) (DNA excision repair protein ERCC-2).

ERCC2_MOUSE
θ value	0 (rank : 2)	NC score	0.999083 (rank : 2)
Query Neighborhood Hits	21	Target Neighborhood Hits	25	Shared Neighborhood Hits	17
SwissProt Accessions	O08811, Q9DC01	Gene names	Ercc2, Xpd
Domain Architecture
Description	TFIIH basal transcription factor complex helicase subunit (EC 3.6.1.-) (DNA-repair protein complementing XP-D cells) (Xeroderma pigmentosum group D-complementing protein) (CXPD) (DNA excision repair protein ERCC-2).

RTEL1_HUMAN
θ value	7.75577e-52 (rank : 3)	NC score	0.815878 (rank : 3)
Query Neighborhood Hits	21	Target Neighborhood Hits	116	Shared Neighborhood Hits	7
SwissProt Accessions	Q9NZ71, Q5JTV4, Q9BW37, Q9H402, Q9H4X6, Q9NX25, Q9NZ73, Q9UPR4, Q9Y4R6	Gene names	RTEL1, C20orf41, KIAA1088, NHL
Domain Architecture
Description	Regulator of telomere elongation helicase 1 (EC 3.6.1.-) (Helicase- like protein NHL).

FANCJ_HUMAN
θ value	1.91475e-42 (rank : 4)	NC score	0.759372 (rank : 5)
Query Neighborhood Hits	21	Target Neighborhood Hits	72	Shared Neighborhood Hits	7
SwissProt Accessions	Q9BX63, Q8NCI5	Gene names	BRIP1, BACH1, FANCJ
Domain Architecture	No domain graphic available
Description	Fanconi anemia group J protein (EC 3.6.1.-) (ATP-dependent RNA helicase BRIP1) (Protein FACJ) (BRCA1-interacting protein C-terminal helicase 1) (BRCA1-interacting protein 1) (BRCA1-associated C-terminal helicase 1).

DDX11_MOUSE
θ value	2.19075e-38 (rank : 5)	NC score	0.779825 (rank : 4)
Query Neighborhood Hits	21	Target Neighborhood Hits	40	Shared Neighborhood Hits	7
SwissProt Accessions	Q6AXC6	Gene names	Ddx11
Domain Architecture	No domain graphic available
Description	Probable ATP-dependent RNA helicase DDX11 (EC 3.6.1.-) (DEAD/H box protein 11).

DDX11_HUMAN
θ value	2.77131e-33 (rank : 6)	NC score	0.749870 (rank : 6)
Query Neighborhood Hits	21	Target Neighborhood Hits	124	Shared Neighborhood Hits	8
SwissProt Accessions	Q96FC9, Q13333, Q86VQ4, Q86W62, Q92498, Q92770, Q92998, Q92999	Gene names	DDX11, CHL1, CHLR1, KRG2
Domain Architecture	No domain graphic available
Description	Probable ATP-dependent RNA helicase DDX11 (EC 3.6.1.-) (DEAD/H box protein 11) (CHL1 homolog) (Keratinocyte growth factor-regulated gene 2 protein) (KRG-2).

FANCJ_MOUSE
θ value	1.80048e-24 (rank : 7)	NC score	0.709493 (rank : 7)
Query Neighborhood Hits	21	Target Neighborhood Hits	57	Shared Neighborhood Hits	7
SwissProt Accessions	Q5SXJ3, Q8BJQ8, Q8BKI6	Gene names	Brip1, Bach1, Fancj
Domain Architecture	No domain graphic available
Description	Fanconi anemia group J protein homolog (EC 3.6.1.-) (ATP-dependent RNA helicase BRIP1) (Protein FACJ) (BRCA1-interacting protein C-terminal helicase 1) (BRCA1-interacting protein 1) (BRCA1-associated C-terminal helicase 1).

PGM2_MOUSE
θ value	0.0431538 (rank : 8)	NC score	0.080010 (rank : 8)
Query Neighborhood Hits	21	Target Neighborhood Hits	11	Shared Neighborhood Hits	4
SwissProt Accessions	Q7TSV4, Q8K0P7, Q9CRS8	Gene names	Pgm2
Domain Architecture	No domain graphic available
Description	Phosphoglucomutase-2 (EC 5.4.2.2) (Glucose phosphomutase 2) (PGM 2).

E41L3_MOUSE
θ value	0.813845 (rank : 9)	NC score	0.021347 (rank : 14)
Query Neighborhood Hits	21	Target Neighborhood Hits	250	Shared Neighborhood Hits	4
SwissProt Accessions	Q9WV92, Q9R102	Gene names	Epb41l3, Dal1, Epb4.1l3
Domain Architecture
Description	Band 4.1-like protein 3 (4.1B) (Differentially expressed in adenocarcinoma of the lung protein 1) (DAL-1) (DAL1P) (mDAL-1).

PGM2_HUMAN
θ value	1.38821 (rank : 10)	NC score	0.055976 (rank : 9)
Query Neighborhood Hits	21	Target Neighborhood Hits	12	Shared Neighborhood Hits	4
SwissProt Accessions	Q96G03, Q53FP5, Q5QTR0, Q9H0P9, Q9NV22	Gene names	PGM2
Domain Architecture	No domain graphic available
Description	Phosphoglucomutase-2 (EC 5.4.2.2) (Glucose phosphomutase 2) (PGM 2).

GASP2_HUMAN
θ value	1.81305 (rank : 11)	NC score	0.030452 (rank : 11)
Query Neighborhood Hits	21	Target Neighborhood Hits	130	Shared Neighborhood Hits	4
SwissProt Accessions	Q96D09, Q8NAB4	Gene names	GPRASP2
Domain Architecture	No domain graphic available
Description	G-protein coupled receptor-associated sorting protein 2 (GASP-2).

GASP2_MOUSE
θ value	1.81305 (rank : 12)	NC score	0.029259 (rank : 13)
Query Neighborhood Hits	21	Target Neighborhood Hits	228	Shared Neighborhood Hits	4
SwissProt Accessions	Q8BUY8	Gene names	Gprasp2
Domain Architecture	No domain graphic available
Description	G-protein coupled receptor-associated sorting protein 2 (GASP-2).

FANCG_HUMAN
θ value	2.36792 (rank : 13)	NC score	0.041079 (rank : 10)
Query Neighborhood Hits	21	Target Neighborhood Hits	17	Shared Neighborhood Hits	3
SwissProt Accessions	O15287	Gene names	FANCG, XRCC9
Domain Architecture	No domain graphic available
Description	Fanconi anemia group G protein (Protein FACG) (DNA-repair protein XRCC9).

GRAP1_MOUSE
θ value	2.36792 (rank : 14)	NC score	0.008492 (rank : 19)
Query Neighborhood Hits	21	Target Neighborhood Hits	1234	Shared Neighborhood Hits	3
SwissProt Accessions	Q8VD04, O35693, Q3T9C3, Q69ZP9	Gene names	Gripap1, DXImx47e, Kiaa1167
Domain Architecture	No domain graphic available
Description	GRIP1-associated protein 1 (GRASP-1) (HCMV-interacting protein).

TEKT2_MOUSE
θ value	3.0926 (rank : 15)	NC score	0.029799 (rank : 12)
Query Neighborhood Hits	21	Target Neighborhood Hits	199	Shared Neighborhood Hits	3
SwissProt Accessions	Q922G7, Q9WVR0	Gene names	Tekt2
Domain Architecture
Description	Tektin-2 (Testicular tektin) (Tektin-t).

CAC1S_MOUSE
θ value	4.03905 (rank : 16)	NC score	0.008997 (rank : 18)
Query Neighborhood Hits	21	Target Neighborhood Hits	98	Shared Neighborhood Hits	3
SwissProt Accessions	Q02789, Q99240	Gene names	Cacna1s, Cach1, Cach1b, Cacn1, Cacnl1a3
Domain Architecture	No domain graphic available
Description	Voltage-dependent L-type calcium channel subunit alpha-1S (Voltage- gated calcium channel subunit alpha Cav1.1) (Calcium channel, L type, alpha-1 polypeptide, isoform 3, skeletal muscle).

ULK3_MOUSE
θ value	5.27518 (rank : 17)	NC score	0.001084 (rank : 21)
Query Neighborhood Hits	21	Target Neighborhood Hits	872	Shared Neighborhood Hits	3
SwissProt Accessions	Q3U3Q1, Q8K1X6, Q9DBR8	Gene names	Ulk3
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase ULK3 (EC 2.7.11.1) (Unc-51-like kinase 3).

GPR98_HUMAN
θ value	6.88961 (rank : 18)	NC score	0.012729 (rank : 16)
Query Neighborhood Hits	21	Target Neighborhood Hits	202	Shared Neighborhood Hits	3
SwissProt Accessions	Q8WXG9, O75171, Q9H0X5, Q9UL61	Gene names	GPR98, KIAA0686, MASS1, VLGR1
Domain Architecture	No domain graphic available
Description	G-protein coupled receptor 98 precursor (Monogenic audiogenic seizure susceptibility protein 1 homolog) (Very large G-protein coupled receptor 1) (Usher syndrome type-2C protein).

DDX55_HUMAN
θ value	8.99809 (rank : 19)	NC score	0.003364 (rank : 20)
Query Neighborhood Hits	21	Target Neighborhood Hits	122	Shared Neighborhood Hits	2
SwissProt Accessions	Q8NHQ9, Q658L6, Q9HCH7	Gene names	DDX55, KIAA1595
Domain Architecture	No domain graphic available
Description	ATP-dependent RNA helicase DDX55 (EC 3.6.1.-) (DEAD box protein 55).

E41L3_HUMAN
θ value	8.99809 (rank : 20)	NC score	0.010140 (rank : 17)
Query Neighborhood Hits	21	Target Neighborhood Hits	113	Shared Neighborhood Hits	3
SwissProt Accessions	Q9Y2J2, O95713, Q9BRP5	Gene names	EPB41L3, DAL1, KIAA0987
Domain Architecture
Description	Band 4.1-like protein 3 (4.1B) (Differentially expressed in adenocarcinoma of the lung protein 1) (DAL-1).

PDRG1_MOUSE
θ value	8.99809 (rank : 21)	NC score	0.017253 (rank : 15)
Query Neighborhood Hits	21	Target Neighborhood Hits	10	Shared Neighborhood Hits	2
SwissProt Accessions	P59048	Gene names	Pdrg1, Pdrg
Domain Architecture	No domain graphic available
Description	p53 and DNA damage-regulated protein 1.

Hits sorted by NC score

ERCC2_HUMAN
NC score	0.999962 (rank : 1)	θ value	0 (rank : 1)
Query Neighborhood Hits	21	Target Neighborhood Hits	21	Shared Neighborhood Hits	21
SwissProt Accessions	P18074, Q8N721	Gene names	ERCC2, XPD, XPDC
Domain Architecture
Description	TFIIH basal transcription factor complex helicase subunit (EC 3.6.1.-) (DNA-repair protein complementing XP-D cells) (Xeroderma pigmentosum group D-complementing protein) (CXPD) (DNA excision repair protein ERCC-2).

ERCC2_MOUSE
NC score	0.999083 (rank : 2)	θ value	0 (rank : 2)
Query Neighborhood Hits	21	Target Neighborhood Hits	25	Shared Neighborhood Hits	17
SwissProt Accessions	O08811, Q9DC01	Gene names	Ercc2, Xpd
Domain Architecture
Description	TFIIH basal transcription factor complex helicase subunit (EC 3.6.1.-) (DNA-repair protein complementing XP-D cells) (Xeroderma pigmentosum group D-complementing protein) (CXPD) (DNA excision repair protein ERCC-2).

RTEL1_HUMAN
NC score	0.815878 (rank : 3)	θ value	7.75577e-52 (rank : 3)
Query Neighborhood Hits	21	Target Neighborhood Hits	116	Shared Neighborhood Hits	7
SwissProt Accessions	Q9NZ71, Q5JTV4, Q9BW37, Q9H402, Q9H4X6, Q9NX25, Q9NZ73, Q9UPR4, Q9Y4R6	Gene names	RTEL1, C20orf41, KIAA1088, NHL
Domain Architecture
Description	Regulator of telomere elongation helicase 1 (EC 3.6.1.-) (Helicase- like protein NHL).

DDX11_MOUSE
NC score	0.779825 (rank : 4)	θ value	2.19075e-38 (rank : 5)
Query Neighborhood Hits	21	Target Neighborhood Hits	40	Shared Neighborhood Hits	7
SwissProt Accessions	Q6AXC6	Gene names	Ddx11
Domain Architecture	No domain graphic available
Description	Probable ATP-dependent RNA helicase DDX11 (EC 3.6.1.-) (DEAD/H box protein 11).

FANCJ_HUMAN
NC score	0.759372 (rank : 5)	θ value	1.91475e-42 (rank : 4)
Query Neighborhood Hits	21	Target Neighborhood Hits	72	Shared Neighborhood Hits	7
SwissProt Accessions	Q9BX63, Q8NCI5	Gene names	BRIP1, BACH1, FANCJ
Domain Architecture	No domain graphic available
Description	Fanconi anemia group J protein (EC 3.6.1.-) (ATP-dependent RNA helicase BRIP1) (Protein FACJ) (BRCA1-interacting protein C-terminal helicase 1) (BRCA1-interacting protein 1) (BRCA1-associated C-terminal helicase 1).

DDX11_HUMAN
NC score	0.749870 (rank : 6)	θ value	2.77131e-33 (rank : 6)
Query Neighborhood Hits	21	Target Neighborhood Hits	124	Shared Neighborhood Hits	8
SwissProt Accessions	Q96FC9, Q13333, Q86VQ4, Q86W62, Q92498, Q92770, Q92998, Q92999	Gene names	DDX11, CHL1, CHLR1, KRG2
Domain Architecture	No domain graphic available
Description	Probable ATP-dependent RNA helicase DDX11 (EC 3.6.1.-) (DEAD/H box protein 11) (CHL1 homolog) (Keratinocyte growth factor-regulated gene 2 protein) (KRG-2).

FANCJ_MOUSE
NC score	0.709493 (rank : 7)	θ value	1.80048e-24 (rank : 7)
Query Neighborhood Hits	21	Target Neighborhood Hits	57	Shared Neighborhood Hits	7
SwissProt Accessions	Q5SXJ3, Q8BJQ8, Q8BKI6	Gene names	Brip1, Bach1, Fancj
Domain Architecture	No domain graphic available
Description	Fanconi anemia group J protein homolog (EC 3.6.1.-) (ATP-dependent RNA helicase BRIP1) (Protein FACJ) (BRCA1-interacting protein C-terminal helicase 1) (BRCA1-interacting protein 1) (BRCA1-associated C-terminal helicase 1).

PGM2_MOUSE
NC score	0.080010 (rank : 8)	θ value	0.0431538 (rank : 8)
Query Neighborhood Hits	21	Target Neighborhood Hits	11	Shared Neighborhood Hits	4
SwissProt Accessions	Q7TSV4, Q8K0P7, Q9CRS8	Gene names	Pgm2
Domain Architecture	No domain graphic available
Description	Phosphoglucomutase-2 (EC 5.4.2.2) (Glucose phosphomutase 2) (PGM 2).

PGM2_HUMAN
NC score	0.055976 (rank : 9)	θ value	1.38821 (rank : 10)
Query Neighborhood Hits	21	Target Neighborhood Hits	12	Shared Neighborhood Hits	4
SwissProt Accessions	Q96G03, Q53FP5, Q5QTR0, Q9H0P9, Q9NV22	Gene names	PGM2
Domain Architecture	No domain graphic available
Description	Phosphoglucomutase-2 (EC 5.4.2.2) (Glucose phosphomutase 2) (PGM 2).

FANCG_HUMAN
NC score	0.041079 (rank : 10)	θ value	2.36792 (rank : 13)
Query Neighborhood Hits	21	Target Neighborhood Hits	17	Shared Neighborhood Hits	3
SwissProt Accessions	O15287	Gene names	FANCG, XRCC9
Domain Architecture	No domain graphic available
Description	Fanconi anemia group G protein (Protein FACG) (DNA-repair protein XRCC9).

GASP2_HUMAN
NC score	0.030452 (rank : 11)	θ value	1.81305 (rank : 11)
Query Neighborhood Hits	21	Target Neighborhood Hits	130	Shared Neighborhood Hits	4
SwissProt Accessions	Q96D09, Q8NAB4	Gene names	GPRASP2
Domain Architecture	No domain graphic available
Description	G-protein coupled receptor-associated sorting protein 2 (GASP-2).

TEKT2_MOUSE
NC score	0.029799 (rank : 12)	θ value	3.0926 (rank : 15)
Query Neighborhood Hits	21	Target Neighborhood Hits	199	Shared Neighborhood Hits	3
SwissProt Accessions	Q922G7, Q9WVR0	Gene names	Tekt2
Domain Architecture
Description	Tektin-2 (Testicular tektin) (Tektin-t).

GASP2_MOUSE
NC score	0.029259 (rank : 13)	θ value	1.81305 (rank : 12)
Query Neighborhood Hits	21	Target Neighborhood Hits	228	Shared Neighborhood Hits	4
SwissProt Accessions	Q8BUY8	Gene names	Gprasp2
Domain Architecture	No domain graphic available
Description	G-protein coupled receptor-associated sorting protein 2 (GASP-2).

E41L3_MOUSE
NC score	0.021347 (rank : 14)	θ value	0.813845 (rank : 9)
Query Neighborhood Hits	21	Target Neighborhood Hits	250	Shared Neighborhood Hits	4
SwissProt Accessions	Q9WV92, Q9R102	Gene names	Epb41l3, Dal1, Epb4.1l3
Domain Architecture
Description	Band 4.1-like protein 3 (4.1B) (Differentially expressed in adenocarcinoma of the lung protein 1) (DAL-1) (DAL1P) (mDAL-1).

PDRG1_MOUSE
NC score	0.017253 (rank : 15)	θ value	8.99809 (rank : 21)
Query Neighborhood Hits	21	Target Neighborhood Hits	10	Shared Neighborhood Hits	2
SwissProt Accessions	P59048	Gene names	Pdrg1, Pdrg
Domain Architecture	No domain graphic available
Description	p53 and DNA damage-regulated protein 1.

GPR98_HUMAN
NC score	0.012729 (rank : 16)	θ value	6.88961 (rank : 18)
Query Neighborhood Hits	21	Target Neighborhood Hits	202	Shared Neighborhood Hits	3
SwissProt Accessions	Q8WXG9, O75171, Q9H0X5, Q9UL61	Gene names	GPR98, KIAA0686, MASS1, VLGR1
Domain Architecture	No domain graphic available
Description	G-protein coupled receptor 98 precursor (Monogenic audiogenic seizure susceptibility protein 1 homolog) (Very large G-protein coupled receptor 1) (Usher syndrome type-2C protein).

E41L3_HUMAN
NC score	0.010140 (rank : 17)	θ value	8.99809 (rank : 20)
Query Neighborhood Hits	21	Target Neighborhood Hits	113	Shared Neighborhood Hits	3
SwissProt Accessions	Q9Y2J2, O95713, Q9BRP5	Gene names	EPB41L3, DAL1, KIAA0987
Domain Architecture
Description	Band 4.1-like protein 3 (4.1B) (Differentially expressed in adenocarcinoma of the lung protein 1) (DAL-1).

CAC1S_MOUSE
NC score	0.008997 (rank : 18)	θ value	4.03905 (rank : 16)
Query Neighborhood Hits	21	Target Neighborhood Hits	98	Shared Neighborhood Hits	3
SwissProt Accessions	Q02789, Q99240	Gene names	Cacna1s, Cach1, Cach1b, Cacn1, Cacnl1a3
Domain Architecture	No domain graphic available
Description	Voltage-dependent L-type calcium channel subunit alpha-1S (Voltage- gated calcium channel subunit alpha Cav1.1) (Calcium channel, L type, alpha-1 polypeptide, isoform 3, skeletal muscle).

GRAP1_MOUSE
NC score	0.008492 (rank : 19)	θ value	2.36792 (rank : 14)
Query Neighborhood Hits	21	Target Neighborhood Hits	1234	Shared Neighborhood Hits	3
SwissProt Accessions	Q8VD04, O35693, Q3T9C3, Q69ZP9	Gene names	Gripap1, DXImx47e, Kiaa1167
Domain Architecture	No domain graphic available
Description	GRIP1-associated protein 1 (GRASP-1) (HCMV-interacting protein).

DDX55_HUMAN
NC score	0.003364 (rank : 20)	θ value	8.99809 (rank : 19)
Query Neighborhood Hits	21	Target Neighborhood Hits	122	Shared Neighborhood Hits	2
SwissProt Accessions	Q8NHQ9, Q658L6, Q9HCH7	Gene names	DDX55, KIAA1595
Domain Architecture	No domain graphic available
Description	ATP-dependent RNA helicase DDX55 (EC 3.6.1.-) (DEAD box protein 55).

ULK3_MOUSE
NC score	0.001084 (rank : 21)	θ value	5.27518 (rank : 17)
Query Neighborhood Hits	21	Target Neighborhood Hits	872	Shared Neighborhood Hits	3
SwissProt Accessions	Q3U3Q1, Q8K1X6, Q9DBR8	Gene names	Ulk3
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase ULK3 (EC 2.7.11.1) (Unc-51-like kinase 3).