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Network neighborhood for query Sequence : ENW1_HUMAN

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ENW1_HUMAN
SwissProt Accessions	Q9UQF0, O95244, O95245, Q8NHY7, Q9NRZ2, Q9NZG3	Gene names	ERVWE1
Domain Architecture
Description	HERV-W_7q21.2 provirus ancestral Env polyprotein precursor (Envelope polyprotein gPr73) (HERV-7q Envelope protein) (HERV-W envelope protein) (Syncytin) (Syncytin-1) (Enverin) (Env-W) [Contains: Surface protein (SU) (gp50); Transmembrane protein (TM) (gp24)].
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

ENW1_HUMAN
θ value	0 (rank : 1)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	22	Target Neighborhood Hits	22	Shared Neighborhood Hits	22
SwissProt Accessions	Q9UQF0, O95244, O95245, Q8NHY7, Q9NRZ2, Q9NZG3	Gene names	ERVWE1
Domain Architecture
Description	HERV-W_7q21.2 provirus ancestral Env polyprotein precursor (Envelope polyprotein gPr73) (HERV-7q Envelope protein) (HERV-W envelope protein) (Syncytin) (Syncytin-1) (Enverin) (Env-W) [Contains: Surface protein (SU) (gp50); Transmembrane protein (TM) (gp24)].

ENH1_HUMAN
θ value	1.91475e-42 (rank : 2)	NC score	0.771822 (rank : 7)
Query Neighborhood Hits	22	Target Neighborhood Hits	25	Shared Neighborhood Hits	13
SwissProt Accessions	Q9N2K0, O00354, Q96L63, Q9UNM3	Gene names
Domain Architecture
Description	HERV-H_2q24.3 provirus ancestral Env polyprotein precursor (Envelope polyprotein) (Env protein HERV-H/p62) (Env protein HERV-H19) (HERV- H/env62) (Env protein HERV-Hcl.3) [Contains: Surface protein (SU); Transmembrane protein (TM)].

ENH2_HUMAN
θ value	1.32909e-35 (rank : 3)	NC score	0.751357 (rank : 8)
Query Neighborhood Hits	22	Target Neighborhood Hits	30	Shared Neighborhood Hits	13
SwissProt Accessions	Q9N2J9	Gene names
Domain Architecture
Description	HERV-H_3q26 provirus ancestral Env polyprotein precursor (Envelope polyprotein) (Env protein HERV-H/p60) (HERV-H/env60) [Contains: Surface protein (SU); Transmembrane protein (TM)].

ENH3_HUMAN
θ value	2.77131e-33 (rank : 4)	NC score	0.737408 (rank : 9)
Query Neighborhood Hits	22	Target Neighborhood Hits	30	Shared Neighborhood Hits	13
SwissProt Accessions	Q9N2J8	Gene names
Domain Architecture
Description	HERV-H_2q24.1 provirus ancestral Env polyprotein precursor (Envelope polyprotein) (Env protein HERV-H/p59) (HERV-H/env59) [Contains: Surface protein (SU); Transmembrane protein (TM)].

EFC1_HUMAN
θ value	1.16434e-31 (rank : 5)	NC score	0.821260 (rank : 3)
Query Neighborhood Hits	22	Target Neighborhood Hits	20	Shared Neighborhood Hits	11
SwissProt Accessions	P60507	Gene names
Domain Architecture	No domain graphic available
Description	HERV-F(c)1_Xq21.33 provirus ancestral Env polyprotein precursor (Envelope polyprotein) (Fc1env) (HERV-Fc1env) [Contains: Surface protein (SU); Transmembrane protein (TM)].

EFR1_HUMAN
θ value	7.06379e-29 (rank : 6)	NC score	0.827188 (rank : 2)
Query Neighborhood Hits	22	Target Neighborhood Hits	14	Shared Neighborhood Hits	13
SwissProt Accessions	P60508	Gene names	ERVFRDE1
Domain Architecture
Description	HERV-FRD_6p24.1 provirus ancestral Env polyprotein precursor (Envelope polyprotein) (HERV-FRD) (Syncytin-2) [Contains: Surface protein (SU); Transmembrane protein (TM)].

ENV2_MOUSE
θ value	7.06379e-29 (rank : 7)	NC score	0.811634 (rank : 4)
Query Neighborhood Hits	22	Target Neighborhood Hits	39	Shared Neighborhood Hits	11
SwissProt Accessions	P11370, Q61529	Gene names	Fv4, Env
Domain Architecture
Description	Retrovirus-related Env polyprotein from Fv-4 locus.

ENT1_HUMAN
θ value	2.77775e-25 (rank : 8)	NC score	0.804418 (rank : 5)
Query Neighborhood Hits	22	Target Neighborhood Hits	18	Shared Neighborhood Hits	12
SwissProt Accessions	P61550	Gene names
Domain Architecture	No domain graphic available
Description	HERV-T_19q13.11 provirus ancestral Env polyprotein precursor (Envelope polyprotein) (HERV-T Env protein) [Includes: Surface protein (SU); Transmembrane protein (TM)].

EFC2_HUMAN
θ value	3.07116e-24 (rank : 9)	NC score	0.788975 (rank : 6)
Query Neighborhood Hits	22	Target Neighborhood Hits	19	Shared Neighborhood Hits	11
SwissProt Accessions	P60608	Gene names
Domain Architecture	No domain graphic available
Description	HERV-F(c)2_7q36.2 provirus ancestral Env polyprotein (Envelope polyprotein) (Fc2deltaenv) [Includes: Surface protein (SU); Truncated transmembrane protein (TM)].

ENR1_HUMAN
θ value	2.44474e-05 (rank : 10)	NC score	0.411416 (rank : 13)
Query Neighborhood Hits	22	Target Neighborhood Hits	16	Shared Neighborhood Hits	13
SwissProt Accessions	Q14264	Gene names	ERV3
Domain Architecture	No domain graphic available
Description	HERV-R_7q21.2 provirus ancestral Env polyprotein precursor (Envelope polyprotein) (ERV3 envelope protein) (ERV-3 envelope protein) (HERV-R envelope protein) (ERV-R envelope protein) [Contains: Surface protein (SU); Transmembrane protein (TM)].

ERB1_HUMAN
θ value	3.19293e-05 (rank : 11)	NC score	0.515543 (rank : 12)
Query Neighborhood Hits	22	Target Neighborhood Hits	23	Shared Neighborhood Hits	12
SwissProt Accessions	P60509	Gene names
Domain Architecture	No domain graphic available
Description	HERV-R(b)_3p24.3 provirus ancestral Env polyprotein precursor (Envelope polyprotein) (HERV-R(b) Env protein) [Includes: Surface protein domain (SU); Transmembrane protein domain (TM)].

ENH5_HUMAN
θ value	0.00665767 (rank : 12)	NC score	0.518741 (rank : 11)
Query Neighborhood Hits	22	Target Neighborhood Hits	14	Shared Neighborhood Hits	8
SwissProt Accessions	P61549	Gene names
Domain Architecture	No domain graphic available
Description	HERV-H_19p13.11 provirus ancestral Env polyprotein precursor (Envelope polyprotein) (Env protein RGH1) (Env protein RTLV-H) [Includes: Surface protein (SU)].

ENH4_HUMAN
θ value	0.0736092 (rank : 13)	NC score	0.519549 (rank : 10)
Query Neighborhood Hits	22	Target Neighborhood Hits	17	Shared Neighborhood Hits	9
SwissProt Accessions	Q96L62	Gene names
Domain Architecture
Description	HERV-H_1q41 provirus ancestral Env polyprotein precursor (Envelope polyprotein) (Env protein HERV-Hcl.7) [Contains: Surface protein (SU); Transmembrane protein (TM)].

DICER_HUMAN
θ value	2.36792 (rank : 14)	NC score	0.028942 (rank : 14)
Query Neighborhood Hits	22	Target Neighborhood Hits	126	Shared Neighborhood Hits	4
SwissProt Accessions	Q9UPY3, O95943, Q9UQ02	Gene names	DICER1, DICER, HERNA, KIAA0928
Domain Architecture
Description	Endoribonuclease Dicer (EC 3.1.26.-) (Helicase with RNase motif) (Helicase-MOI).

TSSP_MOUSE
θ value	2.36792 (rank : 15)	NC score	0.025226 (rank : 16)
Query Neighborhood Hits	22	Target Neighborhood Hits	8	Shared Neighborhood Hits	2
SwissProt Accessions	Q9QXE5	Gene names	Prss16, Tssp
Domain Architecture
Description	Thymus-specific serine protease precursor (EC 3.4.-.-).

HPSE2_HUMAN
θ value	4.03905 (rank : 16)	NC score	0.021995 (rank : 17)
Query Neighborhood Hits	22	Target Neighborhood Hits	8	Shared Neighborhood Hits	2
SwissProt Accessions	Q8WWQ2, Q5VUH4, Q5VUH5, Q5VUH6, Q8WWQ1, Q9HB37, Q9HB38, Q9HB39	Gene names	HPSE2, HPA2
Domain Architecture	No domain graphic available
Description	Heparanase-2 (EC 3.2.-.-) (Hpa2).

DICER_MOUSE
θ value	5.27518 (rank : 17)	NC score	0.025836 (rank : 15)
Query Neighborhood Hits	22	Target Neighborhood Hits	140	Shared Neighborhood Hits	3
SwissProt Accessions	Q8R418	Gene names	Dicer1, Dicer, Mdcr
Domain Architecture
Description	Endoribonuclease Dicer (EC 3.1.26.-) (Double-strand-specific ribonuclease mDCR-1).

NMDE3_MOUSE
θ value	5.27518 (rank : 18)	NC score	0.008696 (rank : 19)
Query Neighborhood Hits	22	Target Neighborhood Hits	86	Shared Neighborhood Hits	3
SwissProt Accessions	Q01098	Gene names	Grin2c
Domain Architecture
Description	Glutamate [NMDA] receptor subunit epsilon 3 precursor (N-methyl D- aspartate receptor subtype 2C) (NR2C) (NMDAR2C).

WNK2_HUMAN
θ value	5.27518 (rank : 19)	NC score	0.000835 (rank : 21)
Query Neighborhood Hits	22	Target Neighborhood Hits	1407	Shared Neighborhood Hits	4
SwissProt Accessions	Q9Y3S1, Q8IY36, Q9C0A3, Q9H3P4	Gene names	WNK2, KIAA1760, PRKWNK2
Domain Architecture
Description	Serine/threonine-protein kinase WNK2 (EC 2.7.11.1) (Protein kinase with no lysine 2) (Protein kinase, lysine-deficient 2).

MD1L1_HUMAN
θ value	8.99809 (rank : 20)	NC score	0.002731 (rank : 20)
Query Neighborhood Hits	22	Target Neighborhood Hits	893	Shared Neighborhood Hits	3
SwissProt Accessions	Q9Y6D9, Q13312, Q75MI0, Q86UM4, Q9UNH0	Gene names	MAD1L1, MAD1, TXBP181
Domain Architecture	No domain graphic available
Description	Mitotic spindle assembly checkpoint protein MAD1 (Mitotic arrest deficient-like protein 1) (MAD1-like 1) (Mitotic checkpoint MAD1 protein-homolog) (HsMAD1) (hMAD1) (Tax-binding protein 181).

PAQRA_HUMAN
θ value	8.99809 (rank : 21)	NC score	0.011518 (rank : 18)
Query Neighborhood Hits	22	Target Neighborhood Hits	8	Shared Neighborhood Hits	2
SwissProt Accessions	Q8IY49, Q6NVU5, Q6TCH0	Gene names	MMD2, PAQR10
Domain Architecture	No domain graphic available
Description	Monocyte to macrophage differentiation factor 2 (Progestin and adipoQ receptor family member X).

TITIN_HUMAN
θ value	8.99809 (rank : 22)	NC score	-0.001616 (rank : 22)
Query Neighborhood Hits	22	Target Neighborhood Hits	2923	Shared Neighborhood Hits	4
SwissProt Accessions	Q8WZ42, Q10465, Q10466, Q15598, Q2XUS3, Q32Q60, Q4U1Z6, Q6NSG0, Q6PDB1, Q6PJP0, Q7KYM2, Q7KYN4, Q7KYN5, Q7LDM3, Q7Z2X3, Q8TCG8, Q8WZ51, Q8WZ52, Q8WZ53, Q8WZB3, Q92761, Q92762, Q9UD97, Q9UP84, Q9Y6L9	Gene names	TTN
Domain Architecture	No domain graphic available
Description	Titin (EC 2.7.11.1) (Connectin) (Rhabdomyosarcoma antigen MU-RMS- 40.14).

Hits sorted by NC score

ENW1_HUMAN
NC score	0.999962 (rank : 1)	θ value	0 (rank : 1)
Query Neighborhood Hits	22	Target Neighborhood Hits	22	Shared Neighborhood Hits	22
SwissProt Accessions	Q9UQF0, O95244, O95245, Q8NHY7, Q9NRZ2, Q9NZG3	Gene names	ERVWE1
Domain Architecture
Description	HERV-W_7q21.2 provirus ancestral Env polyprotein precursor (Envelope polyprotein gPr73) (HERV-7q Envelope protein) (HERV-W envelope protein) (Syncytin) (Syncytin-1) (Enverin) (Env-W) [Contains: Surface protein (SU) (gp50); Transmembrane protein (TM) (gp24)].

EFR1_HUMAN
NC score	0.827188 (rank : 2)	θ value	7.06379e-29 (rank : 6)
Query Neighborhood Hits	22	Target Neighborhood Hits	14	Shared Neighborhood Hits	13
SwissProt Accessions	P60508	Gene names	ERVFRDE1
Domain Architecture
Description	HERV-FRD_6p24.1 provirus ancestral Env polyprotein precursor (Envelope polyprotein) (HERV-FRD) (Syncytin-2) [Contains: Surface protein (SU); Transmembrane protein (TM)].

EFC1_HUMAN
NC score	0.821260 (rank : 3)	θ value	1.16434e-31 (rank : 5)
Query Neighborhood Hits	22	Target Neighborhood Hits	20	Shared Neighborhood Hits	11
SwissProt Accessions	P60507	Gene names
Domain Architecture	No domain graphic available
Description	HERV-F(c)1_Xq21.33 provirus ancestral Env polyprotein precursor (Envelope polyprotein) (Fc1env) (HERV-Fc1env) [Contains: Surface protein (SU); Transmembrane protein (TM)].

ENV2_MOUSE
NC score	0.811634 (rank : 4)	θ value	7.06379e-29 (rank : 7)
Query Neighborhood Hits	22	Target Neighborhood Hits	39	Shared Neighborhood Hits	11
SwissProt Accessions	P11370, Q61529	Gene names	Fv4, Env
Domain Architecture
Description	Retrovirus-related Env polyprotein from Fv-4 locus.

ENT1_HUMAN
NC score	0.804418 (rank : 5)	θ value	2.77775e-25 (rank : 8)
Query Neighborhood Hits	22	Target Neighborhood Hits	18	Shared Neighborhood Hits	12
SwissProt Accessions	P61550	Gene names
Domain Architecture	No domain graphic available
Description	HERV-T_19q13.11 provirus ancestral Env polyprotein precursor (Envelope polyprotein) (HERV-T Env protein) [Includes: Surface protein (SU); Transmembrane protein (TM)].

EFC2_HUMAN
NC score	0.788975 (rank : 6)	θ value	3.07116e-24 (rank : 9)
Query Neighborhood Hits	22	Target Neighborhood Hits	19	Shared Neighborhood Hits	11
SwissProt Accessions	P60608	Gene names
Domain Architecture	No domain graphic available
Description	HERV-F(c)2_7q36.2 provirus ancestral Env polyprotein (Envelope polyprotein) (Fc2deltaenv) [Includes: Surface protein (SU); Truncated transmembrane protein (TM)].

ENH1_HUMAN
NC score	0.771822 (rank : 7)	θ value	1.91475e-42 (rank : 2)
Query Neighborhood Hits	22	Target Neighborhood Hits	25	Shared Neighborhood Hits	13
SwissProt Accessions	Q9N2K0, O00354, Q96L63, Q9UNM3	Gene names
Domain Architecture
Description	HERV-H_2q24.3 provirus ancestral Env polyprotein precursor (Envelope polyprotein) (Env protein HERV-H/p62) (Env protein HERV-H19) (HERV- H/env62) (Env protein HERV-Hcl.3) [Contains: Surface protein (SU); Transmembrane protein (TM)].

ENH2_HUMAN
NC score	0.751357 (rank : 8)	θ value	1.32909e-35 (rank : 3)
Query Neighborhood Hits	22	Target Neighborhood Hits	30	Shared Neighborhood Hits	13
SwissProt Accessions	Q9N2J9	Gene names
Domain Architecture
Description	HERV-H_3q26 provirus ancestral Env polyprotein precursor (Envelope polyprotein) (Env protein HERV-H/p60) (HERV-H/env60) [Contains: Surface protein (SU); Transmembrane protein (TM)].

ENH3_HUMAN
NC score	0.737408 (rank : 9)	θ value	2.77131e-33 (rank : 4)
Query Neighborhood Hits	22	Target Neighborhood Hits	30	Shared Neighborhood Hits	13
SwissProt Accessions	Q9N2J8	Gene names
Domain Architecture
Description	HERV-H_2q24.1 provirus ancestral Env polyprotein precursor (Envelope polyprotein) (Env protein HERV-H/p59) (HERV-H/env59) [Contains: Surface protein (SU); Transmembrane protein (TM)].

ENH4_HUMAN
NC score	0.519549 (rank : 10)	θ value	0.0736092 (rank : 13)
Query Neighborhood Hits	22	Target Neighborhood Hits	17	Shared Neighborhood Hits	9
SwissProt Accessions	Q96L62	Gene names
Domain Architecture
Description	HERV-H_1q41 provirus ancestral Env polyprotein precursor (Envelope polyprotein) (Env protein HERV-Hcl.7) [Contains: Surface protein (SU); Transmembrane protein (TM)].

ENH5_HUMAN
NC score	0.518741 (rank : 11)	θ value	0.00665767 (rank : 12)
Query Neighborhood Hits	22	Target Neighborhood Hits	14	Shared Neighborhood Hits	8
SwissProt Accessions	P61549	Gene names
Domain Architecture	No domain graphic available
Description	HERV-H_19p13.11 provirus ancestral Env polyprotein precursor (Envelope polyprotein) (Env protein RGH1) (Env protein RTLV-H) [Includes: Surface protein (SU)].

ERB1_HUMAN
NC score	0.515543 (rank : 12)	θ value	3.19293e-05 (rank : 11)
Query Neighborhood Hits	22	Target Neighborhood Hits	23	Shared Neighborhood Hits	12
SwissProt Accessions	P60509	Gene names
Domain Architecture	No domain graphic available
Description	HERV-R(b)_3p24.3 provirus ancestral Env polyprotein precursor (Envelope polyprotein) (HERV-R(b) Env protein) [Includes: Surface protein domain (SU); Transmembrane protein domain (TM)].

ENR1_HUMAN
NC score	0.411416 (rank : 13)	θ value	2.44474e-05 (rank : 10)
Query Neighborhood Hits	22	Target Neighborhood Hits	16	Shared Neighborhood Hits	13
SwissProt Accessions	Q14264	Gene names	ERV3
Domain Architecture	No domain graphic available
Description	HERV-R_7q21.2 provirus ancestral Env polyprotein precursor (Envelope polyprotein) (ERV3 envelope protein) (ERV-3 envelope protein) (HERV-R envelope protein) (ERV-R envelope protein) [Contains: Surface protein (SU); Transmembrane protein (TM)].

DICER_HUMAN
NC score	0.028942 (rank : 14)	θ value	2.36792 (rank : 14)
Query Neighborhood Hits	22	Target Neighborhood Hits	126	Shared Neighborhood Hits	4
SwissProt Accessions	Q9UPY3, O95943, Q9UQ02	Gene names	DICER1, DICER, HERNA, KIAA0928
Domain Architecture
Description	Endoribonuclease Dicer (EC 3.1.26.-) (Helicase with RNase motif) (Helicase-MOI).

DICER_MOUSE
NC score	0.025836 (rank : 15)	θ value	5.27518 (rank : 17)
Query Neighborhood Hits	22	Target Neighborhood Hits	140	Shared Neighborhood Hits	3
SwissProt Accessions	Q8R418	Gene names	Dicer1, Dicer, Mdcr
Domain Architecture
Description	Endoribonuclease Dicer (EC 3.1.26.-) (Double-strand-specific ribonuclease mDCR-1).

TSSP_MOUSE
NC score	0.025226 (rank : 16)	θ value	2.36792 (rank : 15)
Query Neighborhood Hits	22	Target Neighborhood Hits	8	Shared Neighborhood Hits	2
SwissProt Accessions	Q9QXE5	Gene names	Prss16, Tssp
Domain Architecture
Description	Thymus-specific serine protease precursor (EC 3.4.-.-).

HPSE2_HUMAN
NC score	0.021995 (rank : 17)	θ value	4.03905 (rank : 16)
Query Neighborhood Hits	22	Target Neighborhood Hits	8	Shared Neighborhood Hits	2
SwissProt Accessions	Q8WWQ2, Q5VUH4, Q5VUH5, Q5VUH6, Q8WWQ1, Q9HB37, Q9HB38, Q9HB39	Gene names	HPSE2, HPA2
Domain Architecture	No domain graphic available
Description	Heparanase-2 (EC 3.2.-.-) (Hpa2).

PAQRA_HUMAN
NC score	0.011518 (rank : 18)	θ value	8.99809 (rank : 21)
Query Neighborhood Hits	22	Target Neighborhood Hits	8	Shared Neighborhood Hits	2
SwissProt Accessions	Q8IY49, Q6NVU5, Q6TCH0	Gene names	MMD2, PAQR10
Domain Architecture	No domain graphic available
Description	Monocyte to macrophage differentiation factor 2 (Progestin and adipoQ receptor family member X).

NMDE3_MOUSE
NC score	0.008696 (rank : 19)	θ value	5.27518 (rank : 18)
Query Neighborhood Hits	22	Target Neighborhood Hits	86	Shared Neighborhood Hits	3
SwissProt Accessions	Q01098	Gene names	Grin2c
Domain Architecture
Description	Glutamate [NMDA] receptor subunit epsilon 3 precursor (N-methyl D- aspartate receptor subtype 2C) (NR2C) (NMDAR2C).

MD1L1_HUMAN
NC score	0.002731 (rank : 20)	θ value	8.99809 (rank : 20)
Query Neighborhood Hits	22	Target Neighborhood Hits	893	Shared Neighborhood Hits	3
SwissProt Accessions	Q9Y6D9, Q13312, Q75MI0, Q86UM4, Q9UNH0	Gene names	MAD1L1, MAD1, TXBP181
Domain Architecture	No domain graphic available
Description	Mitotic spindle assembly checkpoint protein MAD1 (Mitotic arrest deficient-like protein 1) (MAD1-like 1) (Mitotic checkpoint MAD1 protein-homolog) (HsMAD1) (hMAD1) (Tax-binding protein 181).

WNK2_HUMAN
NC score	0.000835 (rank : 21)	θ value	5.27518 (rank : 19)
Query Neighborhood Hits	22	Target Neighborhood Hits	1407	Shared Neighborhood Hits	4
SwissProt Accessions	Q9Y3S1, Q8IY36, Q9C0A3, Q9H3P4	Gene names	WNK2, KIAA1760, PRKWNK2
Domain Architecture
Description	Serine/threonine-protein kinase WNK2 (EC 2.7.11.1) (Protein kinase with no lysine 2) (Protein kinase, lysine-deficient 2).

TITIN_HUMAN
NC score	-0.001616 (rank : 22)	θ value	8.99809 (rank : 22)
Query Neighborhood Hits	22	Target Neighborhood Hits	2923	Shared Neighborhood Hits	4
SwissProt Accessions	Q8WZ42, Q10465, Q10466, Q15598, Q2XUS3, Q32Q60, Q4U1Z6, Q6NSG0, Q6PDB1, Q6PJP0, Q7KYM2, Q7KYN4, Q7KYN5, Q7LDM3, Q7Z2X3, Q8TCG8, Q8WZ51, Q8WZ52, Q8WZ53, Q8WZB3, Q92761, Q92762, Q9UD97, Q9UP84, Q9Y6L9	Gene names	TTN
Domain Architecture	No domain graphic available
Description	Titin (EC 2.7.11.1) (Connectin) (Rhabdomyosarcoma antigen MU-RMS- 40.14).