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Network neighborhood for query Sequence : BACE1_MOUSE

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BACE1_MOUSE
SwissProt Accessions	P56818, Q544D0	Gene names	Bace1, Bace
Domain Architecture
Description	Beta-secretase 1 precursor (EC 3.4.23.46) (Beta-site APP cleaving enzyme 1) (Beta-site amyloid precursor protein cleaving enzyme 1) (Membrane-associated aspartic protease 2) (Memapsin-2) (Aspartyl protease 2) (Asp 2) (ASP2).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

BACE1_HUMAN
θ value	0 (rank : 1)	NC score	0.999850 (rank : 2)
Query Neighborhood Hits	18	Target Neighborhood Hits	18	Shared Neighborhood Hits	17
SwissProt Accessions	P56817, Q9BYB9, Q9BYC0, Q9BYC1, Q9UJT5	Gene names	BACE1, BACE
Domain Architecture
Description	Beta-secretase 1 precursor (EC 3.4.23.46) (Beta-site APP cleaving enzyme 1) (Beta-site amyloid precursor protein cleaving enzyme 1) (Membrane-associated aspartic protease 2) (Memapsin-2) (Aspartyl protease 2) (Asp 2) (ASP2).

BACE1_MOUSE
θ value	0 (rank : 2)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	18	Target Neighborhood Hits	18	Shared Neighborhood Hits	18
SwissProt Accessions	P56818, Q544D0	Gene names	Bace1, Bace
Domain Architecture
Description	Beta-secretase 1 precursor (EC 3.4.23.46) (Beta-site APP cleaving enzyme 1) (Beta-site amyloid precursor protein cleaving enzyme 1) (Membrane-associated aspartic protease 2) (Memapsin-2) (Aspartyl protease 2) (Asp 2) (ASP2).

BACE2_HUMAN
θ value	3.29472e-127 (rank : 3)	NC score	0.977177 (rank : 3)
Query Neighborhood Hits	18	Target Neighborhood Hits	20	Shared Neighborhood Hits	15
SwissProt Accessions	Q9Y5Z0, Q9UJT6	Gene names	BACE2, ASP21
Domain Architecture
Description	Beta-secretase 2 precursor (EC 3.4.23.45) (Beta-site APP-cleaving enzyme 2) (Aspartyl protease 1) (Asp 1) (ASP1) (Membrane-associated aspartic protease 1) (Memapsin-1) (Down region aspartic protease).

CATD_HUMAN
θ value	1.42661e-21 (rank : 4)	NC score	0.740348 (rank : 5)
Query Neighborhood Hits	18	Target Neighborhood Hits	17	Shared Neighborhood Hits	15
SwissProt Accessions	P07339, Q6IB57	Gene names	CTSD
Domain Architecture
Description	Cathepsin D precursor (EC 3.4.23.5) [Contains: Cathepsin D light chain; Cathepsin D heavy chain].

CATE_HUMAN
θ value	7.0802e-21 (rank : 5)	NC score	0.738608 (rank : 7)
Query Neighborhood Hits	18	Target Neighborhood Hits	20	Shared Neighborhood Hits	15
SwissProt Accessions	P14091, Q9NY58	Gene names	CTSE
Domain Architecture
Description	Cathepsin E precursor (EC 3.4.23.34).

PEPA_HUMAN
θ value	7.82807e-20 (rank : 6)	NC score	0.740406 (rank : 4)
Query Neighborhood Hits	18	Target Neighborhood Hits	22	Shared Neighborhood Hits	15
SwissProt Accessions	P00790, Q8N1E3	Gene names	PGA3
Domain Architecture
Description	Pepsin A precursor (EC 3.4.23.1).

CATD_MOUSE
θ value	1.74391e-19 (rank : 7)	NC score	0.735106 (rank : 9)
Query Neighborhood Hits	18	Target Neighborhood Hits	17	Shared Neighborhood Hits	15
SwissProt Accessions	P18242	Gene names	Ctsd
Domain Architecture
Description	Cathepsin D precursor (EC 3.4.23.5).

CATE_MOUSE
θ value	2.97466e-19 (rank : 8)	NC score	0.735918 (rank : 8)
Query Neighborhood Hits	18	Target Neighborhood Hits	19	Shared Neighborhood Hits	15
SwissProt Accessions	P70269, O35647	Gene names	Ctse
Domain Architecture
Description	Cathepsin E precursor (EC 3.4.23.34).

PEPC_HUMAN
θ value	4.29542e-18 (rank : 9)	NC score	0.739751 (rank : 6)
Query Neighborhood Hits	18	Target Neighborhood Hits	18	Shared Neighborhood Hits	15
SwissProt Accessions	P20142, Q5T3D7, Q5T3D8	Gene names	PGC
Domain Architecture
Description	Gastricsin precursor (EC 3.4.23.3) (Pepsinogen C).

PEPC_MOUSE
θ value	8.95645e-16 (rank : 10)	NC score	0.728723 (rank : 10)
Query Neighborhood Hits	18	Target Neighborhood Hits	17	Shared Neighborhood Hits	15
SwissProt Accessions	Q9D7R7, Q9D7T2	Gene names	Pgc, Upg1
Domain Architecture	No domain graphic available
Description	Gastricsin precursor (EC 3.4.23.3) (Pepsinogen C).

RENI_HUMAN
θ value	8.95645e-16 (rank : 11)	NC score	0.718690 (rank : 11)
Query Neighborhood Hits	18	Target Neighborhood Hits	15	Shared Neighborhood Hits	15
SwissProt Accessions	P00797, Q6T5C2	Gene names	REN
Domain Architecture
Description	Renin precursor (EC 3.4.23.15) (Angiotensinogenase).

RENI1_MOUSE
θ value	1.99529e-15 (rank : 12)	NC score	0.714145 (rank : 12)
Query Neighborhood Hits	18	Target Neighborhood Hits	19	Shared Neighborhood Hits	15
SwissProt Accessions	P06281, P97911, Q543E5, Q62153, Q62154	Gene names	Ren1, Ren, Ren-1
Domain Architecture
Description	Renin-1 precursor (EC 3.4.23.15) (Angiotensinogenase) (Kidney renin).

RENI2_MOUSE
θ value	1.99529e-15 (rank : 13)	NC score	0.712974 (rank : 13)
Query Neighborhood Hits	18	Target Neighborhood Hits	20	Shared Neighborhood Hits	15
SwissProt Accessions	P00796, P70229, P97955, Q62155	Gene names	Ren2, Ren-2
Domain Architecture
Description	Renin-2 precursor (EC 3.4.23.15) (Angiotensinogenase) (Submandibular gland renin) [Contains: Renin-2 heavy chain; Renin-2 light chain].

NAPSA_MOUSE
θ value	5.43371e-13 (rank : 14)	NC score	0.698073 (rank : 14)
Query Neighborhood Hits	18	Target Neighborhood Hits	16	Shared Neighborhood Hits	15
SwissProt Accessions	O09043	Gene names	Napsa, Kdap, Nap
Domain Architecture
Description	Napsin-A precursor (EC 3.4.23.-) (Kidney-derived aspartic protease- like protein) (KDAP-1) (KAP).

NAPSA_HUMAN
θ value	1.9326e-10 (rank : 15)	NC score	0.681927 (rank : 15)
Query Neighborhood Hits	18	Target Neighborhood Hits	17	Shared Neighborhood Hits	15
SwissProt Accessions	O96009	Gene names	NAPSA, NAP1
Domain Architecture
Description	Napsin-A precursor (EC 3.4.23.-) (Napsin-1) (NAPA) (TA01/TA02) (Aspartyl protease 4) (Asp 4) (ASP4).

CA048_HUMAN
θ value	0.62314 (rank : 16)	NC score	0.075485 (rank : 16)
Query Neighborhood Hits	18	Target Neighborhood Hits	14	Shared Neighborhood Hits	4
SwissProt Accessions	Q96IY1, Q5SY75, Q9H2M5, Q9NRN8, Q9Y415	Gene names	C1orf48
Domain Architecture	No domain graphic available
Description	Protein C1orf48.

CA048_MOUSE
θ value	2.36792 (rank : 17)	NC score	0.060458 (rank : 17)
Query Neighborhood Hits	18	Target Neighborhood Hits	10	Shared Neighborhood Hits	4
SwissProt Accessions	Q8K305	Gene names
Domain Architecture	No domain graphic available
Description	Protein C1orf48 homolog.

CCD60_MOUSE
θ value	8.99809 (rank : 18)	NC score	0.011695 (rank : 18)
Query Neighborhood Hits	18	Target Neighborhood Hits	18	Shared Neighborhood Hits	2
SwissProt Accessions	Q8C4J0, Q6DIA4, Q6PAQ3	Gene names	Ccdc60
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 60.

Hits sorted by NC score

BACE1_MOUSE
NC score	0.999962 (rank : 1)	θ value	0 (rank : 2)
Query Neighborhood Hits	18	Target Neighborhood Hits	18	Shared Neighborhood Hits	18
SwissProt Accessions	P56818, Q544D0	Gene names	Bace1, Bace
Domain Architecture
Description	Beta-secretase 1 precursor (EC 3.4.23.46) (Beta-site APP cleaving enzyme 1) (Beta-site amyloid precursor protein cleaving enzyme 1) (Membrane-associated aspartic protease 2) (Memapsin-2) (Aspartyl protease 2) (Asp 2) (ASP2).

BACE1_HUMAN
NC score	0.999850 (rank : 2)	θ value	0 (rank : 1)
Query Neighborhood Hits	18	Target Neighborhood Hits	18	Shared Neighborhood Hits	17
SwissProt Accessions	P56817, Q9BYB9, Q9BYC0, Q9BYC1, Q9UJT5	Gene names	BACE1, BACE
Domain Architecture
Description	Beta-secretase 1 precursor (EC 3.4.23.46) (Beta-site APP cleaving enzyme 1) (Beta-site amyloid precursor protein cleaving enzyme 1) (Membrane-associated aspartic protease 2) (Memapsin-2) (Aspartyl protease 2) (Asp 2) (ASP2).

BACE2_HUMAN
NC score	0.977177 (rank : 3)	θ value	3.29472e-127 (rank : 3)
Query Neighborhood Hits	18	Target Neighborhood Hits	20	Shared Neighborhood Hits	15
SwissProt Accessions	Q9Y5Z0, Q9UJT6	Gene names	BACE2, ASP21
Domain Architecture
Description	Beta-secretase 2 precursor (EC 3.4.23.45) (Beta-site APP-cleaving enzyme 2) (Aspartyl protease 1) (Asp 1) (ASP1) (Membrane-associated aspartic protease 1) (Memapsin-1) (Down region aspartic protease).

PEPA_HUMAN
NC score	0.740406 (rank : 4)	θ value	7.82807e-20 (rank : 6)
Query Neighborhood Hits	18	Target Neighborhood Hits	22	Shared Neighborhood Hits	15
SwissProt Accessions	P00790, Q8N1E3	Gene names	PGA3
Domain Architecture
Description	Pepsin A precursor (EC 3.4.23.1).

CATD_HUMAN
NC score	0.740348 (rank : 5)	θ value	1.42661e-21 (rank : 4)
Query Neighborhood Hits	18	Target Neighborhood Hits	17	Shared Neighborhood Hits	15
SwissProt Accessions	P07339, Q6IB57	Gene names	CTSD
Domain Architecture
Description	Cathepsin D precursor (EC 3.4.23.5) [Contains: Cathepsin D light chain; Cathepsin D heavy chain].

PEPC_HUMAN
NC score	0.739751 (rank : 6)	θ value	4.29542e-18 (rank : 9)
Query Neighborhood Hits	18	Target Neighborhood Hits	18	Shared Neighborhood Hits	15
SwissProt Accessions	P20142, Q5T3D7, Q5T3D8	Gene names	PGC
Domain Architecture
Description	Gastricsin precursor (EC 3.4.23.3) (Pepsinogen C).

CATE_HUMAN
NC score	0.738608 (rank : 7)	θ value	7.0802e-21 (rank : 5)
Query Neighborhood Hits	18	Target Neighborhood Hits	20	Shared Neighborhood Hits	15
SwissProt Accessions	P14091, Q9NY58	Gene names	CTSE
Domain Architecture
Description	Cathepsin E precursor (EC 3.4.23.34).

CATE_MOUSE
NC score	0.735918 (rank : 8)	θ value	2.97466e-19 (rank : 8)
Query Neighborhood Hits	18	Target Neighborhood Hits	19	Shared Neighborhood Hits	15
SwissProt Accessions	P70269, O35647	Gene names	Ctse
Domain Architecture
Description	Cathepsin E precursor (EC 3.4.23.34).

CATD_MOUSE
NC score	0.735106 (rank : 9)	θ value	1.74391e-19 (rank : 7)
Query Neighborhood Hits	18	Target Neighborhood Hits	17	Shared Neighborhood Hits	15
SwissProt Accessions	P18242	Gene names	Ctsd
Domain Architecture
Description	Cathepsin D precursor (EC 3.4.23.5).

PEPC_MOUSE
NC score	0.728723 (rank : 10)	θ value	8.95645e-16 (rank : 10)
Query Neighborhood Hits	18	Target Neighborhood Hits	17	Shared Neighborhood Hits	15
SwissProt Accessions	Q9D7R7, Q9D7T2	Gene names	Pgc, Upg1
Domain Architecture	No domain graphic available
Description	Gastricsin precursor (EC 3.4.23.3) (Pepsinogen C).

RENI_HUMAN
NC score	0.718690 (rank : 11)	θ value	8.95645e-16 (rank : 11)
Query Neighborhood Hits	18	Target Neighborhood Hits	15	Shared Neighborhood Hits	15
SwissProt Accessions	P00797, Q6T5C2	Gene names	REN
Domain Architecture
Description	Renin precursor (EC 3.4.23.15) (Angiotensinogenase).

RENI1_MOUSE
NC score	0.714145 (rank : 12)	θ value	1.99529e-15 (rank : 12)
Query Neighborhood Hits	18	Target Neighborhood Hits	19	Shared Neighborhood Hits	15
SwissProt Accessions	P06281, P97911, Q543E5, Q62153, Q62154	Gene names	Ren1, Ren, Ren-1
Domain Architecture
Description	Renin-1 precursor (EC 3.4.23.15) (Angiotensinogenase) (Kidney renin).

RENI2_MOUSE
NC score	0.712974 (rank : 13)	θ value	1.99529e-15 (rank : 13)
Query Neighborhood Hits	18	Target Neighborhood Hits	20	Shared Neighborhood Hits	15
SwissProt Accessions	P00796, P70229, P97955, Q62155	Gene names	Ren2, Ren-2
Domain Architecture
Description	Renin-2 precursor (EC 3.4.23.15) (Angiotensinogenase) (Submandibular gland renin) [Contains: Renin-2 heavy chain; Renin-2 light chain].

NAPSA_MOUSE
NC score	0.698073 (rank : 14)	θ value	5.43371e-13 (rank : 14)
Query Neighborhood Hits	18	Target Neighborhood Hits	16	Shared Neighborhood Hits	15
SwissProt Accessions	O09043	Gene names	Napsa, Kdap, Nap
Domain Architecture
Description	Napsin-A precursor (EC 3.4.23.-) (Kidney-derived aspartic protease- like protein) (KDAP-1) (KAP).

NAPSA_HUMAN
NC score	0.681927 (rank : 15)	θ value	1.9326e-10 (rank : 15)
Query Neighborhood Hits	18	Target Neighborhood Hits	17	Shared Neighborhood Hits	15
SwissProt Accessions	O96009	Gene names	NAPSA, NAP1
Domain Architecture
Description	Napsin-A precursor (EC 3.4.23.-) (Napsin-1) (NAPA) (TA01/TA02) (Aspartyl protease 4) (Asp 4) (ASP4).

CA048_HUMAN
NC score	0.075485 (rank : 16)	θ value	0.62314 (rank : 16)
Query Neighborhood Hits	18	Target Neighborhood Hits	14	Shared Neighborhood Hits	4
SwissProt Accessions	Q96IY1, Q5SY75, Q9H2M5, Q9NRN8, Q9Y415	Gene names	C1orf48
Domain Architecture	No domain graphic available
Description	Protein C1orf48.

CA048_MOUSE
NC score	0.060458 (rank : 17)	θ value	2.36792 (rank : 17)
Query Neighborhood Hits	18	Target Neighborhood Hits	10	Shared Neighborhood Hits	4
SwissProt Accessions	Q8K305	Gene names
Domain Architecture	No domain graphic available
Description	Protein C1orf48 homolog.

CCD60_MOUSE
NC score	0.011695 (rank : 18)	θ value	8.99809 (rank : 18)
Query Neighborhood Hits	18	Target Neighborhood Hits	18	Shared Neighborhood Hits	2
SwissProt Accessions	Q8C4J0, Q6DIA4, Q6PAQ3	Gene names	Ccdc60
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 60.