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Network neighborhood for query Sequence : BACE2_HUMAN

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BACE2_HUMAN
SwissProt Accessions	Q9Y5Z0, Q9UJT6	Gene names	BACE2, ASP21
Domain Architecture
Description	Beta-secretase 2 precursor (EC 3.4.23.45) (Beta-site APP-cleaving enzyme 2) (Aspartyl protease 1) (Asp 1) (ASP1) (Membrane-associated aspartic protease 1) (Memapsin-1) (Down region aspartic protease).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

BACE2_HUMAN
θ value	0 (rank : 1)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	20	Target Neighborhood Hits	20	Shared Neighborhood Hits	20
SwissProt Accessions	Q9Y5Z0, Q9UJT6	Gene names	BACE2, ASP21
Domain Architecture
Description	Beta-secretase 2 precursor (EC 3.4.23.45) (Beta-site APP-cleaving enzyme 2) (Aspartyl protease 1) (Asp 1) (ASP1) (Membrane-associated aspartic protease 1) (Memapsin-1) (Down region aspartic protease).

BACE1_HUMAN
θ value	3.29472e-127 (rank : 2)	NC score	0.976835 (rank : 3)
Query Neighborhood Hits	20	Target Neighborhood Hits	18	Shared Neighborhood Hits	15
SwissProt Accessions	P56817, Q9BYB9, Q9BYC0, Q9BYC1, Q9UJT5	Gene names	BACE1, BACE
Domain Architecture
Description	Beta-secretase 1 precursor (EC 3.4.23.46) (Beta-site APP cleaving enzyme 1) (Beta-site amyloid precursor protein cleaving enzyme 1) (Membrane-associated aspartic protease 2) (Memapsin-2) (Aspartyl protease 2) (Asp 2) (ASP2).

BACE1_MOUSE
θ value	3.29472e-127 (rank : 3)	NC score	0.977177 (rank : 2)
Query Neighborhood Hits	20	Target Neighborhood Hits	18	Shared Neighborhood Hits	15
SwissProt Accessions	P56818, Q544D0	Gene names	Bace1, Bace
Domain Architecture
Description	Beta-secretase 1 precursor (EC 3.4.23.46) (Beta-site APP cleaving enzyme 1) (Beta-site amyloid precursor protein cleaving enzyme 1) (Membrane-associated aspartic protease 2) (Memapsin-2) (Aspartyl protease 2) (Asp 2) (ASP2).

PEPC_HUMAN
θ value	1.12775e-26 (rank : 4)	NC score	0.810715 (rank : 4)
Query Neighborhood Hits	20	Target Neighborhood Hits	18	Shared Neighborhood Hits	15
SwissProt Accessions	P20142, Q5T3D7, Q5T3D8	Gene names	PGC
Domain Architecture
Description	Gastricsin precursor (EC 3.4.23.3) (Pepsinogen C).

PEPC_MOUSE
θ value	4.01107e-24 (rank : 5)	NC score	0.801231 (rank : 8)
Query Neighborhood Hits	20	Target Neighborhood Hits	17	Shared Neighborhood Hits	15
SwissProt Accessions	Q9D7R7, Q9D7T2	Gene names	Pgc, Upg1
Domain Architecture	No domain graphic available
Description	Gastricsin precursor (EC 3.4.23.3) (Pepsinogen C).

CATE_MOUSE
θ value	1.16704e-23 (rank : 6)	NC score	0.801693 (rank : 7)
Query Neighborhood Hits	20	Target Neighborhood Hits	19	Shared Neighborhood Hits	15
SwissProt Accessions	P70269, O35647	Gene names	Ctse
Domain Architecture
Description	Cathepsin E precursor (EC 3.4.23.34).

CATD_MOUSE
θ value	5.79196e-23 (rank : 7)	NC score	0.800307 (rank : 10)
Query Neighborhood Hits	20	Target Neighborhood Hits	17	Shared Neighborhood Hits	15
SwissProt Accessions	P18242	Gene names	Ctsd
Domain Architecture
Description	Cathepsin D precursor (EC 3.4.23.5).

RENI1_MOUSE
θ value	2.87452e-22 (rank : 8)	NC score	0.787490 (rank : 12)
Query Neighborhood Hits	20	Target Neighborhood Hits	19	Shared Neighborhood Hits	15
SwissProt Accessions	P06281, P97911, Q543E5, Q62153, Q62154	Gene names	Ren1, Ren, Ren-1
Domain Architecture
Description	Renin-1 precursor (EC 3.4.23.15) (Angiotensinogenase) (Kidney renin).

RENI_HUMAN
θ value	2.87452e-22 (rank : 9)	NC score	0.791092 (rank : 11)
Query Neighborhood Hits	20	Target Neighborhood Hits	15	Shared Neighborhood Hits	15
SwissProt Accessions	P00797, Q6T5C2	Gene names	REN
Domain Architecture
Description	Renin precursor (EC 3.4.23.15) (Angiotensinogenase).

CATD_HUMAN
θ value	3.75424e-22 (rank : 10)	NC score	0.803328 (rank : 6)
Query Neighborhood Hits	20	Target Neighborhood Hits	17	Shared Neighborhood Hits	15
SwissProt Accessions	P07339, Q6IB57	Gene names	CTSD
Domain Architecture
Description	Cathepsin D precursor (EC 3.4.23.5) [Contains: Cathepsin D light chain; Cathepsin D heavy chain].

RENI2_MOUSE
θ value	1.42661e-21 (rank : 11)	NC score	0.786094 (rank : 13)
Query Neighborhood Hits	20	Target Neighborhood Hits	20	Shared Neighborhood Hits	15
SwissProt Accessions	P00796, P70229, P97955, Q62155	Gene names	Ren2, Ren-2
Domain Architecture
Description	Renin-2 precursor (EC 3.4.23.15) (Angiotensinogenase) (Submandibular gland renin) [Contains: Renin-2 heavy chain; Renin-2 light chain].

PEPA_HUMAN
θ value	4.15078e-21 (rank : 12)	NC score	0.804578 (rank : 5)
Query Neighborhood Hits	20	Target Neighborhood Hits	22	Shared Neighborhood Hits	15
SwissProt Accessions	P00790, Q8N1E3	Gene names	PGA3
Domain Architecture
Description	Pepsin A precursor (EC 3.4.23.1).

CATE_HUMAN
θ value	1.5773e-20 (rank : 13)	NC score	0.801213 (rank : 9)
Query Neighborhood Hits	20	Target Neighborhood Hits	20	Shared Neighborhood Hits	15
SwissProt Accessions	P14091, Q9NY58	Gene names	CTSE
Domain Architecture
Description	Cathepsin E precursor (EC 3.4.23.34).

NAPSA_MOUSE
θ value	2.13179e-17 (rank : 14)	NC score	0.770008 (rank : 14)
Query Neighborhood Hits	20	Target Neighborhood Hits	16	Shared Neighborhood Hits	15
SwissProt Accessions	O09043	Gene names	Napsa, Kdap, Nap
Domain Architecture
Description	Napsin-A precursor (EC 3.4.23.-) (Kidney-derived aspartic protease- like protein) (KDAP-1) (KAP).

NAPSA_HUMAN
θ value	4.91457e-14 (rank : 15)	NC score	0.754626 (rank : 15)
Query Neighborhood Hits	20	Target Neighborhood Hits	17	Shared Neighborhood Hits	15
SwissProt Accessions	O96009	Gene names	NAPSA, NAP1
Domain Architecture
Description	Napsin-A precursor (EC 3.4.23.-) (Napsin-1) (NAPA) (TA01/TA02) (Aspartyl protease 4) (Asp 4) (ASP4).

WDR6_HUMAN
θ value	0.813845 (rank : 16)	NC score	0.028956 (rank : 16)
Query Neighborhood Hits	20	Target Neighborhood Hits	193	Shared Neighborhood Hits	2
SwissProt Accessions	Q9NNW5, Q9UF63	Gene names	WDR6
Domain Architecture
Description	WD repeat protein 6.

PKD1_HUMAN
θ value	1.38821 (rank : 17)	NC score	0.016012 (rank : 19)
Query Neighborhood Hits	20	Target Neighborhood Hits	387	Shared Neighborhood Hits	2
SwissProt Accessions	P98161, Q15140, Q15141	Gene names	PKD1
Domain Architecture
Description	Polycystin-1 precursor (Autosomal dominant polycystic kidney disease protein 1).

K0310_HUMAN
θ value	3.0926 (rank : 18)	NC score	0.021083 (rank : 17)
Query Neighborhood Hits	20	Target Neighborhood Hits	420	Shared Neighborhood Hits	2
SwissProt Accessions	O15027, Q5SXP0, Q5SXP1, Q8N347, Q96HP1	Gene names	KIAA0310
Domain Architecture	No domain graphic available
Description	Protein KIAA0310.

NDUB8_HUMAN
θ value	6.88961 (rank : 19)	NC score	0.016712 (rank : 18)
Query Neighborhood Hits	20	Target Neighborhood Hits	4	Shared Neighborhood Hits	2
SwissProt Accessions	O95169, Q5W144, Q9UG53, Q9UJR4, Q9UQF3	Gene names	NDUFB8
Domain Architecture
Description	NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial precursor (EC 1.6.5.3) (EC 1.6.99.3) (NADH-ubiquinone oxidoreductase ASHI subunit) (Complex I-ASHI) (CI-ASHI).

GDF9_MOUSE
θ value	8.99809 (rank : 20)	NC score	0.005715 (rank : 20)
Query Neighborhood Hits	20	Target Neighborhood Hits	63	Shared Neighborhood Hits	2
SwissProt Accessions	Q07105	Gene names	Gdf9, Gdf-9
Domain Architecture
Description	Growth/differentiation factor 9 precursor (GDF-9).

Hits sorted by NC score

BACE2_HUMAN
NC score	0.999962 (rank : 1)	θ value	0 (rank : 1)
Query Neighborhood Hits	20	Target Neighborhood Hits	20	Shared Neighborhood Hits	20
SwissProt Accessions	Q9Y5Z0, Q9UJT6	Gene names	BACE2, ASP21
Domain Architecture
Description	Beta-secretase 2 precursor (EC 3.4.23.45) (Beta-site APP-cleaving enzyme 2) (Aspartyl protease 1) (Asp 1) (ASP1) (Membrane-associated aspartic protease 1) (Memapsin-1) (Down region aspartic protease).

BACE1_MOUSE
NC score	0.977177 (rank : 2)	θ value	3.29472e-127 (rank : 3)
Query Neighborhood Hits	20	Target Neighborhood Hits	18	Shared Neighborhood Hits	15
SwissProt Accessions	P56818, Q544D0	Gene names	Bace1, Bace
Domain Architecture
Description	Beta-secretase 1 precursor (EC 3.4.23.46) (Beta-site APP cleaving enzyme 1) (Beta-site amyloid precursor protein cleaving enzyme 1) (Membrane-associated aspartic protease 2) (Memapsin-2) (Aspartyl protease 2) (Asp 2) (ASP2).

BACE1_HUMAN
NC score	0.976835 (rank : 3)	θ value	3.29472e-127 (rank : 2)
Query Neighborhood Hits	20	Target Neighborhood Hits	18	Shared Neighborhood Hits	15
SwissProt Accessions	P56817, Q9BYB9, Q9BYC0, Q9BYC1, Q9UJT5	Gene names	BACE1, BACE
Domain Architecture
Description	Beta-secretase 1 precursor (EC 3.4.23.46) (Beta-site APP cleaving enzyme 1) (Beta-site amyloid precursor protein cleaving enzyme 1) (Membrane-associated aspartic protease 2) (Memapsin-2) (Aspartyl protease 2) (Asp 2) (ASP2).

PEPC_HUMAN
NC score	0.810715 (rank : 4)	θ value	1.12775e-26 (rank : 4)
Query Neighborhood Hits	20	Target Neighborhood Hits	18	Shared Neighborhood Hits	15
SwissProt Accessions	P20142, Q5T3D7, Q5T3D8	Gene names	PGC
Domain Architecture
Description	Gastricsin precursor (EC 3.4.23.3) (Pepsinogen C).

PEPA_HUMAN
NC score	0.804578 (rank : 5)	θ value	4.15078e-21 (rank : 12)
Query Neighborhood Hits	20	Target Neighborhood Hits	22	Shared Neighborhood Hits	15
SwissProt Accessions	P00790, Q8N1E3	Gene names	PGA3
Domain Architecture
Description	Pepsin A precursor (EC 3.4.23.1).

CATD_HUMAN
NC score	0.803328 (rank : 6)	θ value	3.75424e-22 (rank : 10)
Query Neighborhood Hits	20	Target Neighborhood Hits	17	Shared Neighborhood Hits	15
SwissProt Accessions	P07339, Q6IB57	Gene names	CTSD
Domain Architecture
Description	Cathepsin D precursor (EC 3.4.23.5) [Contains: Cathepsin D light chain; Cathepsin D heavy chain].

CATE_MOUSE
NC score	0.801693 (rank : 7)	θ value	1.16704e-23 (rank : 6)
Query Neighborhood Hits	20	Target Neighborhood Hits	19	Shared Neighborhood Hits	15
SwissProt Accessions	P70269, O35647	Gene names	Ctse
Domain Architecture
Description	Cathepsin E precursor (EC 3.4.23.34).

PEPC_MOUSE
NC score	0.801231 (rank : 8)	θ value	4.01107e-24 (rank : 5)
Query Neighborhood Hits	20	Target Neighborhood Hits	17	Shared Neighborhood Hits	15
SwissProt Accessions	Q9D7R7, Q9D7T2	Gene names	Pgc, Upg1
Domain Architecture	No domain graphic available
Description	Gastricsin precursor (EC 3.4.23.3) (Pepsinogen C).

CATE_HUMAN
NC score	0.801213 (rank : 9)	θ value	1.5773e-20 (rank : 13)
Query Neighborhood Hits	20	Target Neighborhood Hits	20	Shared Neighborhood Hits	15
SwissProt Accessions	P14091, Q9NY58	Gene names	CTSE
Domain Architecture
Description	Cathepsin E precursor (EC 3.4.23.34).

CATD_MOUSE
NC score	0.800307 (rank : 10)	θ value	5.79196e-23 (rank : 7)
Query Neighborhood Hits	20	Target Neighborhood Hits	17	Shared Neighborhood Hits	15
SwissProt Accessions	P18242	Gene names	Ctsd
Domain Architecture
Description	Cathepsin D precursor (EC 3.4.23.5).

RENI_HUMAN
NC score	0.791092 (rank : 11)	θ value	2.87452e-22 (rank : 9)
Query Neighborhood Hits	20	Target Neighborhood Hits	15	Shared Neighborhood Hits	15
SwissProt Accessions	P00797, Q6T5C2	Gene names	REN
Domain Architecture
Description	Renin precursor (EC 3.4.23.15) (Angiotensinogenase).

RENI1_MOUSE
NC score	0.787490 (rank : 12)	θ value	2.87452e-22 (rank : 8)
Query Neighborhood Hits	20	Target Neighborhood Hits	19	Shared Neighborhood Hits	15
SwissProt Accessions	P06281, P97911, Q543E5, Q62153, Q62154	Gene names	Ren1, Ren, Ren-1
Domain Architecture
Description	Renin-1 precursor (EC 3.4.23.15) (Angiotensinogenase) (Kidney renin).

RENI2_MOUSE
NC score	0.786094 (rank : 13)	θ value	1.42661e-21 (rank : 11)
Query Neighborhood Hits	20	Target Neighborhood Hits	20	Shared Neighborhood Hits	15
SwissProt Accessions	P00796, P70229, P97955, Q62155	Gene names	Ren2, Ren-2
Domain Architecture
Description	Renin-2 precursor (EC 3.4.23.15) (Angiotensinogenase) (Submandibular gland renin) [Contains: Renin-2 heavy chain; Renin-2 light chain].

NAPSA_MOUSE
NC score	0.770008 (rank : 14)	θ value	2.13179e-17 (rank : 14)
Query Neighborhood Hits	20	Target Neighborhood Hits	16	Shared Neighborhood Hits	15
SwissProt Accessions	O09043	Gene names	Napsa, Kdap, Nap
Domain Architecture
Description	Napsin-A precursor (EC 3.4.23.-) (Kidney-derived aspartic protease- like protein) (KDAP-1) (KAP).

NAPSA_HUMAN
NC score	0.754626 (rank : 15)	θ value	4.91457e-14 (rank : 15)
Query Neighborhood Hits	20	Target Neighborhood Hits	17	Shared Neighborhood Hits	15
SwissProt Accessions	O96009	Gene names	NAPSA, NAP1
Domain Architecture
Description	Napsin-A precursor (EC 3.4.23.-) (Napsin-1) (NAPA) (TA01/TA02) (Aspartyl protease 4) (Asp 4) (ASP4).

WDR6_HUMAN
NC score	0.028956 (rank : 16)	θ value	0.813845 (rank : 16)
Query Neighborhood Hits	20	Target Neighborhood Hits	193	Shared Neighborhood Hits	2
SwissProt Accessions	Q9NNW5, Q9UF63	Gene names	WDR6
Domain Architecture
Description	WD repeat protein 6.

K0310_HUMAN
NC score	0.021083 (rank : 17)	θ value	3.0926 (rank : 18)
Query Neighborhood Hits	20	Target Neighborhood Hits	420	Shared Neighborhood Hits	2
SwissProt Accessions	O15027, Q5SXP0, Q5SXP1, Q8N347, Q96HP1	Gene names	KIAA0310
Domain Architecture	No domain graphic available
Description	Protein KIAA0310.

NDUB8_HUMAN
NC score	0.016712 (rank : 18)	θ value	6.88961 (rank : 19)
Query Neighborhood Hits	20	Target Neighborhood Hits	4	Shared Neighborhood Hits	2
SwissProt Accessions	O95169, Q5W144, Q9UG53, Q9UJR4, Q9UQF3	Gene names	NDUFB8
Domain Architecture
Description	NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial precursor (EC 1.6.5.3) (EC 1.6.99.3) (NADH-ubiquinone oxidoreductase ASHI subunit) (Complex I-ASHI) (CI-ASHI).

PKD1_HUMAN
NC score	0.016012 (rank : 19)	θ value	1.38821 (rank : 17)
Query Neighborhood Hits	20	Target Neighborhood Hits	387	Shared Neighborhood Hits	2
SwissProt Accessions	P98161, Q15140, Q15141	Gene names	PKD1
Domain Architecture
Description	Polycystin-1 precursor (Autosomal dominant polycystic kidney disease protein 1).

GDF9_MOUSE
NC score	0.005715 (rank : 20)	θ value	8.99809 (rank : 20)
Query Neighborhood Hits	20	Target Neighborhood Hits	63	Shared Neighborhood Hits	2
SwissProt Accessions	Q07105	Gene names	Gdf9, Gdf-9
Domain Architecture
Description	Growth/differentiation factor 9 precursor (GDF-9).