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Network neighborhood for query Sequence : TRM1_HUMAN

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TRM1_HUMAN
SwissProt Accessions	Q9NXH9, O76103, Q548Y5, Q8WVA6	Gene names	TRMT1
Domain Architecture
Description	N(2),N(2)-dimethylguanosine tRNA methyltransferase (EC 2.1.1.32) (tRNA(guanine-26,N(2)-N(2)) methyltransferase) (tRNA 2,2- dimethylguanosine-26 methyltransferase) (tRNA(m(2,2)G26)dimethyltransferase).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

TRM1_HUMAN
θ value	0 (rank : 1)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	37	Target Neighborhood Hits	37	Shared Neighborhood Hits	37
SwissProt Accessions	Q9NXH9, O76103, Q548Y5, Q8WVA6	Gene names	TRMT1
Domain Architecture
Description	N(2),N(2)-dimethylguanosine tRNA methyltransferase (EC 2.1.1.32) (tRNA(guanine-26,N(2)-N(2)) methyltransferase) (tRNA 2,2- dimethylguanosine-26 methyltransferase) (tRNA(m(2,2)G26)dimethyltransferase).

TRM1_MOUSE
θ value	0 (rank : 2)	NC score	0.988372 (rank : 2)
Query Neighborhood Hits	37	Target Neighborhood Hits	28	Shared Neighborhood Hits	17
SwissProt Accessions	Q3TX08, Q3TBY4	Gene names	Trmt1, D8Ertd812e
Domain Architecture	No domain graphic available
Description	N(2),N(2)-dimethylguanosine tRNA methyltransferase (EC 2.1.1.32) (tRNA(guanine-26,N(2)-N(2)) methyltransferase) (tRNA 2,2- dimethylguanosine-26 methyltransferase) (tRNA(m(2,2)G26)dimethyltransferase).

SMRC1_HUMAN
θ value	0.0961366 (rank : 3)	NC score	0.044154 (rank : 22)
Query Neighborhood Hits	37	Target Neighborhood Hits	375	Shared Neighborhood Hits	5
SwissProt Accessions	Q92922, Q6P172, Q8IWH2	Gene names	SMARCC1, BAF155
Domain Architecture	No domain graphic available
Description	SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily C member 1 (SWI/SNF complex 155 kDa subunit) (BRG1-associated factor 155).

M3K8_HUMAN
θ value	0.163984 (rank : 4)	NC score	0.016287 (rank : 32)
Query Neighborhood Hits	37	Target Neighborhood Hits	807	Shared Neighborhood Hits	4
SwissProt Accessions	P41279, Q14275, Q9HC81	Gene names	MAP3K8, COT
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 8 (EC 2.7.11.25) (COT proto-oncogene serine/threonine-protein kinase) (C-COT) (Cancer Osaka thyroid oncogene).

MAGI1_HUMAN
θ value	0.62314 (rank : 5)	NC score	0.031879 (rank : 26)
Query Neighborhood Hits	37	Target Neighborhood Hits	388	Shared Neighborhood Hits	4
SwissProt Accessions	Q96QZ7, O00309, O43863, O75085, Q96QZ8, Q96QZ9	Gene names	MAGI1, BAIAP1, BAP1, TNRC19
Domain Architecture	No domain graphic available
Description	Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 (BAI1-associated protein 1) (BAP-1) (Membrane-associated guanylate kinase inverted 1) (MAGI-1) (Atrophin-1-interacting protein 3) (AIP3) (WW domain-containing protein 3) (WWP3) (Trinucleotide repeat-containing gene 19 protein).

MKRN1_HUMAN
θ value	0.62314 (rank : 6)	NC score	0.092335 (rank : 5)
Query Neighborhood Hits	37	Target Neighborhood Hits	141	Shared Neighborhood Hits	23
SwissProt Accessions	Q9UHC7, Q6GSF1, Q9H0G0, Q9UEZ7	Gene names	MKRN1, RNF61
Domain Architecture
Description	Makorin-1 (RING finger protein 61).

ZC3H8_HUMAN
θ value	0.62314 (rank : 7)	NC score	0.093219 (rank : 4)
Query Neighborhood Hits	37	Target Neighborhood Hits	57	Shared Neighborhood Hits	21
SwissProt Accessions	Q8N5P1, Q9BZ75	Gene names	ZC3H8, ZC3HDC8
Domain Architecture	No domain graphic available
Description	Zinc finger CCCH domain-containing protein 8.

M3K8_MOUSE
θ value	0.813845 (rank : 8)	NC score	0.014136 (rank : 35)
Query Neighborhood Hits	37	Target Neighborhood Hits	815	Shared Neighborhood Hits	4
SwissProt Accessions	Q07174	Gene names	Map3k8, Cot
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 8 (EC 2.7.11.25) (COT proto-oncogene serine/threonine-protein kinase) (C-COT) (Cancer Osaka thyroid oncogene).

ZC3H8_MOUSE
θ value	1.06291 (rank : 9)	NC score	0.101310 (rank : 3)
Query Neighborhood Hits	37	Target Neighborhood Hits	56	Shared Neighborhood Hits	22
SwissProt Accessions	Q9JJ48, Q80X92	Gene names	Zc3h8, Fliz1, Zc3hdc8
Domain Architecture	No domain graphic available
Description	Zinc finger CCCH domain-containing protein 8 (Fetal liver zinc finger protein 1).

MKRN1_MOUSE
θ value	1.38821 (rank : 10)	NC score	0.090489 (rank : 6)
Query Neighborhood Hits	37	Target Neighborhood Hits	141	Shared Neighborhood Hits	22
SwissProt Accessions	Q9QXP6	Gene names	Mkrn1
Domain Architecture
Description	Makorin-1.

MKRN4_HUMAN
θ value	1.38821 (rank : 11)	NC score	0.089494 (rank : 7)
Query Neighborhood Hits	37	Target Neighborhood Hits	147	Shared Neighborhood Hits	19
SwissProt Accessions	Q13434	Gene names	MKRN4, RNF64, ZNF127L1
Domain Architecture	No domain graphic available
Description	Makorin-4 (Zinc finger protein 127-Xp) (ZNF127-Xp) (RING finger protein 64).

MAGI1_MOUSE
θ value	1.81305 (rank : 12)	NC score	0.026347 (rank : 28)
Query Neighborhood Hits	37	Target Neighborhood Hits	403	Shared Neighborhood Hits	3
SwissProt Accessions	Q6RHR9, O54893, O54894, O54895	Gene names	Magi1, Baiap1, Bap1
Domain Architecture	No domain graphic available
Description	Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 (BAI1-associated protein 1) (BAP-1) (Membrane-associated guanylate kinase inverted 1) (MAGI-1).

ZC3H5_MOUSE
θ value	1.81305 (rank : 13)	NC score	0.045421 (rank : 21)
Query Neighborhood Hits	37	Target Neighborhood Hits	136	Shared Neighborhood Hits	18
SwissProt Accessions	Q8BL48, Q8BVI6, Q99JZ8, Q99LL9	Gene names	Zc3h5, Kiaa1753, Zc3hdc5
Domain Architecture	No domain graphic available
Description	Zinc finger CCCH domain-containing protein 5.

CS007_HUMAN
θ value	2.36792 (rank : 14)	NC score	0.083428 (rank : 10)
Query Neighborhood Hits	37	Target Neighborhood Hits	401	Shared Neighborhood Hits	23
SwissProt Accessions	Q9UPT8, Q9Y420	Gene names	C19orf7, KIAA1064
Domain Architecture	No domain graphic available
Description	Zinc finger CCCH domain-containing protein C19orf7.

CS007_MOUSE
θ value	2.36792 (rank : 15)	NC score	0.086585 (rank : 9)
Query Neighborhood Hits	37	Target Neighborhood Hits	464	Shared Neighborhood Hits	24
SwissProt Accessions	Q6ZPZ3	Gene names	Kiaa1064
Domain Architecture	No domain graphic available
Description	Zinc finger CCCH domain-containing protein C19orf7 homolog.

LYAR_HUMAN
θ value	2.36792 (rank : 16)	NC score	0.032539 (rank : 25)
Query Neighborhood Hits	37	Target Neighborhood Hits	155	Shared Neighborhood Hits	2
SwissProt Accessions	Q9NX58, Q6FI78, Q9NYS1	Gene names	LYAR
Domain Architecture	No domain graphic available
Description	Cell growth-regulating nucleolar protein.

MKRN2_HUMAN
θ value	2.36792 (rank : 17)	NC score	0.086690 (rank : 8)
Query Neighborhood Hits	37	Target Neighborhood Hits	129	Shared Neighborhood Hits	22
SwissProt Accessions	Q9H000, Q8N391, Q96BD4, Q9BUY2, Q9NRY1	Gene names	MKRN2, RNF62
Domain Architecture
Description	Makorin-2 (RING finger protein 62).

MKRN2_MOUSE
θ value	2.36792 (rank : 18)	NC score	0.082354 (rank : 11)
Query Neighborhood Hits	37	Target Neighborhood Hits	130	Shared Neighborhood Hits	21
SwissProt Accessions	Q9ERV1, Q9D0L9	Gene names	Mkrn2
Domain Architecture
Description	Makorin-2.

MKRN3_MOUSE
θ value	2.36792 (rank : 19)	NC score	0.073212 (rank : 14)
Query Neighborhood Hits	37	Target Neighborhood Hits	137	Shared Neighborhood Hits	21
SwissProt Accessions	Q60764, Q7TQE4	Gene names	Mkrn3, Zfp127, Znf127
Domain Architecture
Description	Makorin-3 (Zinc finger protein 127).

PGRP2_HUMAN
θ value	2.36792 (rank : 20)	NC score	0.028811 (rank : 27)
Query Neighborhood Hits	37	Target Neighborhood Hits	19	Shared Neighborhood Hits	2
SwissProt Accessions	Q96PD5, Q96N74, Q9UC60	Gene names	PGLYRP2, PGLYRPL, PGRPL
Domain Architecture
Description	N-acetylmuramoyl-L-alanine amidase precursor (EC 3.5.1.28) (Peptidoglycan recognition protein long) (PGRP-L) (Peptidoglycan recognition protein 2).

CPSF4_HUMAN
θ value	4.03905 (rank : 21)	NC score	0.077025 (rank : 13)
Query Neighborhood Hits	37	Target Neighborhood Hits	68	Shared Neighborhood Hits	23
SwissProt Accessions	O95639, Q86TF8, Q9BTW6	Gene names	CPSF4, CPSF30, NAR, NEB1
Domain Architecture
Description	Cleavage and polyadenylation specificity factor 30 kDa subunit (CPSF 30 kDa subunit) (NS1 effector domain-binding protein 1) (Neb-1) (No arches homolog).

CPSF4_MOUSE
θ value	4.03905 (rank : 22)	NC score	0.080576 (rank : 12)
Query Neighborhood Hits	37	Target Neighborhood Hits	58	Shared Neighborhood Hits	23
SwissProt Accessions	Q8BQZ5, O54930	Gene names	Cpsf4, Cpsf30
Domain Architecture
Description	Cleavage and polyadenylation specificity factor 30 kDa subunit (CPSF 30 kDa subunit) (Clipper homolog) (Clipper/CPSF 30K).

ZC3H6_HUMAN
θ value	4.03905 (rank : 23)	NC score	0.064784 (rank : 15)
Query Neighborhood Hits	37	Target Neighborhood Hits	228	Shared Neighborhood Hits	20
SwissProt Accessions	P61129	Gene names	ZC3H6, KIAA2035, ZC3HDC6
Domain Architecture
Description	Zinc finger CCCH domain-containing protein 6.

JHD3B_HUMAN
θ value	5.27518 (rank : 24)	NC score	0.013684 (rank : 36)
Query Neighborhood Hits	37	Target Neighborhood Hits	128	Shared Neighborhood Hits	3
SwissProt Accessions	O94953, O75274, Q6P3R5, Q9P1V1, Q9UF40	Gene names	JMJD2B, JHDM3B, KIAA0876
Domain Architecture
Description	JmjC domain-containing histone demethylation protein 3B (EC 1.14.11.-) (Jumonji domain-containing protein 2B).

RBM22_HUMAN
θ value	5.27518 (rank : 25)	NC score	0.035352 (rank : 23)
Query Neighborhood Hits	37	Target Neighborhood Hits	189	Shared Neighborhood Hits	16
SwissProt Accessions	Q9NW64, O95607	Gene names	RBM22
Domain Architecture	No domain graphic available
Description	Pre-mRNA-splicing factor RBM22 (RNA-binding motif protein 22).

RBM22_MOUSE
θ value	5.27518 (rank : 26)	NC score	0.035352 (rank : 24)
Query Neighborhood Hits	37	Target Neighborhood Hits	189	Shared Neighborhood Hits	16
SwissProt Accessions	Q8BHS3, Q3TJB0, Q9CXA0	Gene names	Rbm22
Domain Architecture	No domain graphic available
Description	Pre-mRNA-splicing factor RBM22 (RNA-binding motif protein 22).

TISB_MOUSE
θ value	5.27518 (rank : 27)	NC score	0.063564 (rank : 16)
Query Neighborhood Hits	37	Target Neighborhood Hits	56	Shared Neighborhood Hits	22
SwissProt Accessions	P23950	Gene names	Zfp36l1, Brf1, Tis11b
Domain Architecture
Description	Butyrate response factor 1 (TIS11B protein).

U2AFM_MOUSE
θ value	5.27518 (rank : 28)	NC score	0.016517 (rank : 31)
Query Neighborhood Hits	37	Target Neighborhood Hits	543	Shared Neighborhood Hits	7
SwissProt Accessions	Q62377	Gene names	Zrsr2, U2af1-rs2, U2af1l2, U2af1rs2
Domain Architecture
Description	U2 small nuclear ribonucleoprotein auxiliary factor 35 kDa subunit- related protein 2 (U2(RNU2) small nuclear RNA auxiliary factor 1-like 2) (CCCH type zinc finger, RNA-binding motif and serine/arginine rich protein 2).

CI093_HUMAN
θ value	6.88961 (rank : 29)	NC score	0.004921 (rank : 38)
Query Neighborhood Hits	37	Target Neighborhood Hits	1088	Shared Neighborhood Hits	6
SwissProt Accessions	Q6TFL3, Q5SU58, Q6P1W1, Q6ZR13, Q8N1Z4, Q8N8L3, Q8TBR2	Gene names	C9orf93
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C9orf93.

DHX57_HUMAN
θ value	6.88961 (rank : 30)	NC score	0.014415 (rank : 34)
Query Neighborhood Hits	37	Target Neighborhood Hits	109	Shared Neighborhood Hits	22
SwissProt Accessions	Q6P158, Q53SI4, Q6P9G1, Q7Z6H3, Q8NG17, Q96M33	Gene names	DHX57
Domain Architecture	No domain graphic available
Description	Putative ATP-dependent RNA helicase DHX57 (EC 3.6.1.-) (DEAH box protein 57).

TISB_HUMAN
θ value	6.88961 (rank : 31)	NC score	0.059306 (rank : 18)
Query Neighborhood Hits	37	Target Neighborhood Hits	56	Shared Neighborhood Hits	22
SwissProt Accessions	Q07352, Q13851	Gene names	ZFP36L1, BERG36, BRF1, ERF1, TIS11B
Domain Architecture
Description	Butyrate response factor 1 (TIS11B protein) (EGF-response factor 1) (ERF-1).

TISD_MOUSE
θ value	6.88961 (rank : 32)	NC score	0.055620 (rank : 19)
Query Neighborhood Hits	37	Target Neighborhood Hits	62	Shared Neighborhood Hits	21
SwissProt Accessions	P23949	Gene names	Zfp36l2, Brf2, Tis11d
Domain Architecture
Description	Butyrate response factor 2 (TIS11D protein).

TITIN_HUMAN
θ value	6.88961 (rank : 33)	NC score	0.003218 (rank : 39)
Query Neighborhood Hits	37	Target Neighborhood Hits	2923	Shared Neighborhood Hits	11
SwissProt Accessions	Q8WZ42, Q10465, Q10466, Q15598, Q2XUS3, Q32Q60, Q4U1Z6, Q6NSG0, Q6PDB1, Q6PJP0, Q7KYM2, Q7KYN4, Q7KYN5, Q7LDM3, Q7Z2X3, Q8TCG8, Q8WZ51, Q8WZ52, Q8WZ53, Q8WZB3, Q92761, Q92762, Q9UD97, Q9UP84, Q9Y6L9	Gene names	TTN
Domain Architecture	No domain graphic available
Description	Titin (EC 2.7.11.1) (Connectin) (Rhabdomyosarcoma antigen MU-RMS- 40.14).

RC3H1_HUMAN
θ value	8.99809 (rank : 34)	NC score	0.017512 (rank : 30)
Query Neighborhood Hits	37	Target Neighborhood Hits	433	Shared Neighborhood Hits	8
SwissProt Accessions	Q5TC82, Q5W180, Q5W181, Q8IVE6, Q8N9V1	Gene names	RC3H1, KIAA2025
Domain Architecture	No domain graphic available
Description	Roquin (RING finger and C3H zinc finger protein 1).

RC3H1_MOUSE
θ value	8.99809 (rank : 35)	NC score	0.018059 (rank : 29)
Query Neighborhood Hits	37	Target Neighborhood Hits	244	Shared Neighborhood Hits	7
SwissProt Accessions	Q4VGL6, Q69Z31	Gene names	Rc3h1, Gm551, Kiaa2025
Domain Architecture	No domain graphic available
Description	Roquin (RING finger and C3H zinc finger protein 1) (Sanroque protein).

SALL2_HUMAN
θ value	8.99809 (rank : 36)	NC score	0.005305 (rank : 37)
Query Neighborhood Hits	37	Target Neighborhood Hits	835	Shared Neighborhood Hits	3
SwissProt Accessions	Q9Y467, Q9Y4G1	Gene names	SALL2, KIAA0360, SAL2
Domain Architecture	No domain graphic available
Description	Sal-like protein 2 (Zinc finger protein SALL2) (HSal2).

U2AFL_MOUSE
θ value	8.99809 (rank : 37)	NC score	0.016247 (rank : 33)
Query Neighborhood Hits	37	Target Neighborhood Hits	389	Shared Neighborhood Hits	7
SwissProt Accessions	Q64707	Gene names	Zrsr1, Sp2, Sp2-7, U2af1-rs1, U2af1l1
Domain Architecture
Description	U2 small nuclear ribonucleoprotein auxiliary factor 35 kDa subunit- related protein 1 (U2(RNU2) small nuclear RNA auxiliary factor 1-like 1) (CCCH type zinc finger, RNA-binding motif and serine/arginine rich protein 1) (SP2).

MKRN3_HUMAN
θ value	θ > 10 (rank : 38)	NC score	0.059726 (rank : 17)
Query Neighborhood Hits	37	Target Neighborhood Hits	165	Shared Neighborhood Hits	17
SwissProt Accessions	Q13064	Gene names	MKRN3, RNF63, ZNF127
Domain Architecture
Description	Makorin-3 (Zinc finger protein 127) (RING finger protein 63).

ZC3H6_MOUSE
θ value	θ > 10 (rank : 39)	NC score	0.055356 (rank : 20)
Query Neighborhood Hits	37	Target Neighborhood Hits	239	Shared Neighborhood Hits	19
SwissProt Accessions	Q8BYK8, Q80UK3, Q8C1H1, Q9D604	Gene names	Zc3h6, Zc3hdc6
Domain Architecture
Description	Zinc finger CCCH domain-containing protein 6.

Hits sorted by NC score

TRM1_HUMAN
NC score	0.999962 (rank : 1)	θ value	0 (rank : 1)
Query Neighborhood Hits	37	Target Neighborhood Hits	37	Shared Neighborhood Hits	37
SwissProt Accessions	Q9NXH9, O76103, Q548Y5, Q8WVA6	Gene names	TRMT1
Domain Architecture
Description	N(2),N(2)-dimethylguanosine tRNA methyltransferase (EC 2.1.1.32) (tRNA(guanine-26,N(2)-N(2)) methyltransferase) (tRNA 2,2- dimethylguanosine-26 methyltransferase) (tRNA(m(2,2)G26)dimethyltransferase).

TRM1_MOUSE
NC score	0.988372 (rank : 2)	θ value	0 (rank : 2)
Query Neighborhood Hits	37	Target Neighborhood Hits	28	Shared Neighborhood Hits	17
SwissProt Accessions	Q3TX08, Q3TBY4	Gene names	Trmt1, D8Ertd812e
Domain Architecture	No domain graphic available
Description	N(2),N(2)-dimethylguanosine tRNA methyltransferase (EC 2.1.1.32) (tRNA(guanine-26,N(2)-N(2)) methyltransferase) (tRNA 2,2- dimethylguanosine-26 methyltransferase) (tRNA(m(2,2)G26)dimethyltransferase).

ZC3H8_MOUSE
NC score	0.101310 (rank : 3)	θ value	1.06291 (rank : 9)
Query Neighborhood Hits	37	Target Neighborhood Hits	56	Shared Neighborhood Hits	22
SwissProt Accessions	Q9JJ48, Q80X92	Gene names	Zc3h8, Fliz1, Zc3hdc8
Domain Architecture	No domain graphic available
Description	Zinc finger CCCH domain-containing protein 8 (Fetal liver zinc finger protein 1).

ZC3H8_HUMAN
NC score	0.093219 (rank : 4)	θ value	0.62314 (rank : 7)
Query Neighborhood Hits	37	Target Neighborhood Hits	57	Shared Neighborhood Hits	21
SwissProt Accessions	Q8N5P1, Q9BZ75	Gene names	ZC3H8, ZC3HDC8
Domain Architecture	No domain graphic available
Description	Zinc finger CCCH domain-containing protein 8.

MKRN1_HUMAN
NC score	0.092335 (rank : 5)	θ value	0.62314 (rank : 6)
Query Neighborhood Hits	37	Target Neighborhood Hits	141	Shared Neighborhood Hits	23
SwissProt Accessions	Q9UHC7, Q6GSF1, Q9H0G0, Q9UEZ7	Gene names	MKRN1, RNF61
Domain Architecture
Description	Makorin-1 (RING finger protein 61).

MKRN1_MOUSE
NC score	0.090489 (rank : 6)	θ value	1.38821 (rank : 10)
Query Neighborhood Hits	37	Target Neighborhood Hits	141	Shared Neighborhood Hits	22
SwissProt Accessions	Q9QXP6	Gene names	Mkrn1
Domain Architecture
Description	Makorin-1.

MKRN4_HUMAN
NC score	0.089494 (rank : 7)	θ value	1.38821 (rank : 11)
Query Neighborhood Hits	37	Target Neighborhood Hits	147	Shared Neighborhood Hits	19
SwissProt Accessions	Q13434	Gene names	MKRN4, RNF64, ZNF127L1
Domain Architecture	No domain graphic available
Description	Makorin-4 (Zinc finger protein 127-Xp) (ZNF127-Xp) (RING finger protein 64).

MKRN2_HUMAN
NC score	0.086690 (rank : 8)	θ value	2.36792 (rank : 17)
Query Neighborhood Hits	37	Target Neighborhood Hits	129	Shared Neighborhood Hits	22
SwissProt Accessions	Q9H000, Q8N391, Q96BD4, Q9BUY2, Q9NRY1	Gene names	MKRN2, RNF62
Domain Architecture
Description	Makorin-2 (RING finger protein 62).

CS007_MOUSE
NC score	0.086585 (rank : 9)	θ value	2.36792 (rank : 15)
Query Neighborhood Hits	37	Target Neighborhood Hits	464	Shared Neighborhood Hits	24
SwissProt Accessions	Q6ZPZ3	Gene names	Kiaa1064
Domain Architecture	No domain graphic available
Description	Zinc finger CCCH domain-containing protein C19orf7 homolog.

CS007_HUMAN
NC score	0.083428 (rank : 10)	θ value	2.36792 (rank : 14)
Query Neighborhood Hits	37	Target Neighborhood Hits	401	Shared Neighborhood Hits	23
SwissProt Accessions	Q9UPT8, Q9Y420	Gene names	C19orf7, KIAA1064
Domain Architecture	No domain graphic available
Description	Zinc finger CCCH domain-containing protein C19orf7.

MKRN2_MOUSE
NC score	0.082354 (rank : 11)	θ value	2.36792 (rank : 18)
Query Neighborhood Hits	37	Target Neighborhood Hits	130	Shared Neighborhood Hits	21
SwissProt Accessions	Q9ERV1, Q9D0L9	Gene names	Mkrn2
Domain Architecture
Description	Makorin-2.

CPSF4_MOUSE
NC score	0.080576 (rank : 12)	θ value	4.03905 (rank : 22)
Query Neighborhood Hits	37	Target Neighborhood Hits	58	Shared Neighborhood Hits	23
SwissProt Accessions	Q8BQZ5, O54930	Gene names	Cpsf4, Cpsf30
Domain Architecture
Description	Cleavage and polyadenylation specificity factor 30 kDa subunit (CPSF 30 kDa subunit) (Clipper homolog) (Clipper/CPSF 30K).

CPSF4_HUMAN
NC score	0.077025 (rank : 13)	θ value	4.03905 (rank : 21)
Query Neighborhood Hits	37	Target Neighborhood Hits	68	Shared Neighborhood Hits	23
SwissProt Accessions	O95639, Q86TF8, Q9BTW6	Gene names	CPSF4, CPSF30, NAR, NEB1
Domain Architecture
Description	Cleavage and polyadenylation specificity factor 30 kDa subunit (CPSF 30 kDa subunit) (NS1 effector domain-binding protein 1) (Neb-1) (No arches homolog).

MKRN3_MOUSE
NC score	0.073212 (rank : 14)	θ value	2.36792 (rank : 19)
Query Neighborhood Hits	37	Target Neighborhood Hits	137	Shared Neighborhood Hits	21
SwissProt Accessions	Q60764, Q7TQE4	Gene names	Mkrn3, Zfp127, Znf127
Domain Architecture
Description	Makorin-3 (Zinc finger protein 127).

ZC3H6_HUMAN
NC score	0.064784 (rank : 15)	θ value	4.03905 (rank : 23)
Query Neighborhood Hits	37	Target Neighborhood Hits	228	Shared Neighborhood Hits	20
SwissProt Accessions	P61129	Gene names	ZC3H6, KIAA2035, ZC3HDC6
Domain Architecture
Description	Zinc finger CCCH domain-containing protein 6.

TISB_MOUSE
NC score	0.063564 (rank : 16)	θ value	5.27518 (rank : 27)
Query Neighborhood Hits	37	Target Neighborhood Hits	56	Shared Neighborhood Hits	22
SwissProt Accessions	P23950	Gene names	Zfp36l1, Brf1, Tis11b
Domain Architecture
Description	Butyrate response factor 1 (TIS11B protein).

MKRN3_HUMAN
NC score	0.059726 (rank : 17)	θ value	θ > 10 (rank : 38)
Query Neighborhood Hits	37	Target Neighborhood Hits	165	Shared Neighborhood Hits	17
SwissProt Accessions	Q13064	Gene names	MKRN3, RNF63, ZNF127
Domain Architecture
Description	Makorin-3 (Zinc finger protein 127) (RING finger protein 63).

TISB_HUMAN
NC score	0.059306 (rank : 18)	θ value	6.88961 (rank : 31)
Query Neighborhood Hits	37	Target Neighborhood Hits	56	Shared Neighborhood Hits	22
SwissProt Accessions	Q07352, Q13851	Gene names	ZFP36L1, BERG36, BRF1, ERF1, TIS11B
Domain Architecture
Description	Butyrate response factor 1 (TIS11B protein) (EGF-response factor 1) (ERF-1).

TISD_MOUSE
NC score	0.055620 (rank : 19)	θ value	6.88961 (rank : 32)
Query Neighborhood Hits	37	Target Neighborhood Hits	62	Shared Neighborhood Hits	21
SwissProt Accessions	P23949	Gene names	Zfp36l2, Brf2, Tis11d
Domain Architecture
Description	Butyrate response factor 2 (TIS11D protein).

ZC3H6_MOUSE
NC score	0.055356 (rank : 20)	θ value	θ > 10 (rank : 39)
Query Neighborhood Hits	37	Target Neighborhood Hits	239	Shared Neighborhood Hits	19
SwissProt Accessions	Q8BYK8, Q80UK3, Q8C1H1, Q9D604	Gene names	Zc3h6, Zc3hdc6
Domain Architecture
Description	Zinc finger CCCH domain-containing protein 6.

ZC3H5_MOUSE
NC score	0.045421 (rank : 21)	θ value	1.81305 (rank : 13)
Query Neighborhood Hits	37	Target Neighborhood Hits	136	Shared Neighborhood Hits	18
SwissProt Accessions	Q8BL48, Q8BVI6, Q99JZ8, Q99LL9	Gene names	Zc3h5, Kiaa1753, Zc3hdc5
Domain Architecture	No domain graphic available
Description	Zinc finger CCCH domain-containing protein 5.

SMRC1_HUMAN
NC score	0.044154 (rank : 22)	θ value	0.0961366 (rank : 3)
Query Neighborhood Hits	37	Target Neighborhood Hits	375	Shared Neighborhood Hits	5
SwissProt Accessions	Q92922, Q6P172, Q8IWH2	Gene names	SMARCC1, BAF155
Domain Architecture	No domain graphic available
Description	SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily C member 1 (SWI/SNF complex 155 kDa subunit) (BRG1-associated factor 155).

RBM22_HUMAN
NC score	0.035352 (rank : 23)	θ value	5.27518 (rank : 25)
Query Neighborhood Hits	37	Target Neighborhood Hits	189	Shared Neighborhood Hits	16
SwissProt Accessions	Q9NW64, O95607	Gene names	RBM22
Domain Architecture	No domain graphic available
Description	Pre-mRNA-splicing factor RBM22 (RNA-binding motif protein 22).

RBM22_MOUSE
NC score	0.035352 (rank : 24)	θ value	5.27518 (rank : 26)
Query Neighborhood Hits	37	Target Neighborhood Hits	189	Shared Neighborhood Hits	16
SwissProt Accessions	Q8BHS3, Q3TJB0, Q9CXA0	Gene names	Rbm22
Domain Architecture	No domain graphic available
Description	Pre-mRNA-splicing factor RBM22 (RNA-binding motif protein 22).

LYAR_HUMAN
NC score	0.032539 (rank : 25)	θ value	2.36792 (rank : 16)
Query Neighborhood Hits	37	Target Neighborhood Hits	155	Shared Neighborhood Hits	2
SwissProt Accessions	Q9NX58, Q6FI78, Q9NYS1	Gene names	LYAR
Domain Architecture	No domain graphic available
Description	Cell growth-regulating nucleolar protein.

MAGI1_HUMAN
NC score	0.031879 (rank : 26)	θ value	0.62314 (rank : 5)
Query Neighborhood Hits	37	Target Neighborhood Hits	388	Shared Neighborhood Hits	4
SwissProt Accessions	Q96QZ7, O00309, O43863, O75085, Q96QZ8, Q96QZ9	Gene names	MAGI1, BAIAP1, BAP1, TNRC19
Domain Architecture	No domain graphic available
Description	Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 (BAI1-associated protein 1) (BAP-1) (Membrane-associated guanylate kinase inverted 1) (MAGI-1) (Atrophin-1-interacting protein 3) (AIP3) (WW domain-containing protein 3) (WWP3) (Trinucleotide repeat-containing gene 19 protein).

PGRP2_HUMAN
NC score	0.028811 (rank : 27)	θ value	2.36792 (rank : 20)
Query Neighborhood Hits	37	Target Neighborhood Hits	19	Shared Neighborhood Hits	2
SwissProt Accessions	Q96PD5, Q96N74, Q9UC60	Gene names	PGLYRP2, PGLYRPL, PGRPL
Domain Architecture
Description	N-acetylmuramoyl-L-alanine amidase precursor (EC 3.5.1.28) (Peptidoglycan recognition protein long) (PGRP-L) (Peptidoglycan recognition protein 2).

MAGI1_MOUSE
NC score	0.026347 (rank : 28)	θ value	1.81305 (rank : 12)
Query Neighborhood Hits	37	Target Neighborhood Hits	403	Shared Neighborhood Hits	3
SwissProt Accessions	Q6RHR9, O54893, O54894, O54895	Gene names	Magi1, Baiap1, Bap1
Domain Architecture	No domain graphic available
Description	Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 (BAI1-associated protein 1) (BAP-1) (Membrane-associated guanylate kinase inverted 1) (MAGI-1).

RC3H1_MOUSE
NC score	0.018059 (rank : 29)	θ value	8.99809 (rank : 35)
Query Neighborhood Hits	37	Target Neighborhood Hits	244	Shared Neighborhood Hits	7
SwissProt Accessions	Q4VGL6, Q69Z31	Gene names	Rc3h1, Gm551, Kiaa2025
Domain Architecture	No domain graphic available
Description	Roquin (RING finger and C3H zinc finger protein 1) (Sanroque protein).

RC3H1_HUMAN
NC score	0.017512 (rank : 30)	θ value	8.99809 (rank : 34)
Query Neighborhood Hits	37	Target Neighborhood Hits	433	Shared Neighborhood Hits	8
SwissProt Accessions	Q5TC82, Q5W180, Q5W181, Q8IVE6, Q8N9V1	Gene names	RC3H1, KIAA2025
Domain Architecture	No domain graphic available
Description	Roquin (RING finger and C3H zinc finger protein 1).

U2AFM_MOUSE
NC score	0.016517 (rank : 31)	θ value	5.27518 (rank : 28)
Query Neighborhood Hits	37	Target Neighborhood Hits	543	Shared Neighborhood Hits	7
SwissProt Accessions	Q62377	Gene names	Zrsr2, U2af1-rs2, U2af1l2, U2af1rs2
Domain Architecture
Description	U2 small nuclear ribonucleoprotein auxiliary factor 35 kDa subunit- related protein 2 (U2(RNU2) small nuclear RNA auxiliary factor 1-like 2) (CCCH type zinc finger, RNA-binding motif and serine/arginine rich protein 2).

M3K8_HUMAN
NC score	0.016287 (rank : 32)	θ value	0.163984 (rank : 4)
Query Neighborhood Hits	37	Target Neighborhood Hits	807	Shared Neighborhood Hits	4
SwissProt Accessions	P41279, Q14275, Q9HC81	Gene names	MAP3K8, COT
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 8 (EC 2.7.11.25) (COT proto-oncogene serine/threonine-protein kinase) (C-COT) (Cancer Osaka thyroid oncogene).

U2AFL_MOUSE
NC score	0.016247 (rank : 33)	θ value	8.99809 (rank : 37)
Query Neighborhood Hits	37	Target Neighborhood Hits	389	Shared Neighborhood Hits	7
SwissProt Accessions	Q64707	Gene names	Zrsr1, Sp2, Sp2-7, U2af1-rs1, U2af1l1
Domain Architecture
Description	U2 small nuclear ribonucleoprotein auxiliary factor 35 kDa subunit- related protein 1 (U2(RNU2) small nuclear RNA auxiliary factor 1-like 1) (CCCH type zinc finger, RNA-binding motif and serine/arginine rich protein 1) (SP2).

DHX57_HUMAN
NC score	0.014415 (rank : 34)	θ value	6.88961 (rank : 30)
Query Neighborhood Hits	37	Target Neighborhood Hits	109	Shared Neighborhood Hits	22
SwissProt Accessions	Q6P158, Q53SI4, Q6P9G1, Q7Z6H3, Q8NG17, Q96M33	Gene names	DHX57
Domain Architecture	No domain graphic available
Description	Putative ATP-dependent RNA helicase DHX57 (EC 3.6.1.-) (DEAH box protein 57).

M3K8_MOUSE
NC score	0.014136 (rank : 35)	θ value	0.813845 (rank : 8)
Query Neighborhood Hits	37	Target Neighborhood Hits	815	Shared Neighborhood Hits	4
SwissProt Accessions	Q07174	Gene names	Map3k8, Cot
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 8 (EC 2.7.11.25) (COT proto-oncogene serine/threonine-protein kinase) (C-COT) (Cancer Osaka thyroid oncogene).

JHD3B_HUMAN
NC score	0.013684 (rank : 36)	θ value	5.27518 (rank : 24)
Query Neighborhood Hits	37	Target Neighborhood Hits	128	Shared Neighborhood Hits	3
SwissProt Accessions	O94953, O75274, Q6P3R5, Q9P1V1, Q9UF40	Gene names	JMJD2B, JHDM3B, KIAA0876
Domain Architecture
Description	JmjC domain-containing histone demethylation protein 3B (EC 1.14.11.-) (Jumonji domain-containing protein 2B).

SALL2_HUMAN
NC score	0.005305 (rank : 37)	θ value	8.99809 (rank : 36)
Query Neighborhood Hits	37	Target Neighborhood Hits	835	Shared Neighborhood Hits	3
SwissProt Accessions	Q9Y467, Q9Y4G1	Gene names	SALL2, KIAA0360, SAL2
Domain Architecture	No domain graphic available
Description	Sal-like protein 2 (Zinc finger protein SALL2) (HSal2).

CI093_HUMAN
NC score	0.004921 (rank : 38)	θ value	6.88961 (rank : 29)
Query Neighborhood Hits	37	Target Neighborhood Hits	1088	Shared Neighborhood Hits	6
SwissProt Accessions	Q6TFL3, Q5SU58, Q6P1W1, Q6ZR13, Q8N1Z4, Q8N8L3, Q8TBR2	Gene names	C9orf93
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C9orf93.

TITIN_HUMAN
NC score	0.003218 (rank : 39)	θ value	6.88961 (rank : 33)
Query Neighborhood Hits	37	Target Neighborhood Hits	2923	Shared Neighborhood Hits	11
SwissProt Accessions	Q8WZ42, Q10465, Q10466, Q15598, Q2XUS3, Q32Q60, Q4U1Z6, Q6NSG0, Q6PDB1, Q6PJP0, Q7KYM2, Q7KYN4, Q7KYN5, Q7LDM3, Q7Z2X3, Q8TCG8, Q8WZ51, Q8WZ52, Q8WZ53, Q8WZB3, Q92761, Q92762, Q9UD97, Q9UP84, Q9Y6L9	Gene names	TTN
Domain Architecture	No domain graphic available
Description	Titin (EC 2.7.11.1) (Connectin) (Rhabdomyosarcoma antigen MU-RMS- 40.14).