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Network neighborhood for query Sequence : TMC8_HUMAN

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TMC8_HUMAN
SwissProt Accessions	Q8IU68, Q8IWU7, Q8N358, Q8NF04	Gene names	TMC8, EVER2, EVIN2
Domain Architecture	No domain graphic available
Description	Transmembrane channel-like protein 8 (Epidermodysplasia verruciformis protein 2).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

TMC8_HUMAN
θ value	0 (rank : 1)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	23	Target Neighborhood Hits	23	Shared Neighborhood Hits	23
SwissProt Accessions	Q8IU68, Q8IWU7, Q8N358, Q8NF04	Gene names	TMC8, EVER2, EVIN2
Domain Architecture	No domain graphic available
Description	Transmembrane channel-like protein 8 (Epidermodysplasia verruciformis protein 2).

TMC8_MOUSE
θ value	0 (rank : 2)	NC score	0.994256 (rank : 2)
Query Neighborhood Hits	23	Target Neighborhood Hits	11	Shared Neighborhood Hits	8
SwissProt Accessions	Q7TN58, Q3TAL0, Q3UWI0, Q7TQ67	Gene names	Tmc8, Ever2
Domain Architecture	No domain graphic available
Description	Transmembrane channel-like protein 8 (Epidermodysplasia verruciformis protein 2 homolog).

TMC2_HUMAN
θ value	9.52487e-34 (rank : 3)	NC score	0.758635 (rank : 4)
Query Neighborhood Hits	23	Target Neighborhood Hits	149	Shared Neighborhood Hits	8
SwissProt Accessions	Q8TDI7, Q5JXT0, Q5JXT1, Q6UWW4, Q6ZS41, Q8N9F3, Q9BYN2, Q9BYN3, Q9BYN4, Q9BYN5	Gene names	TMC2
Domain Architecture	No domain graphic available
Description	Transmembrane cochlear-expressed protein 2.

TMC2_MOUSE
θ value	1.24399e-33 (rank : 4)	NC score	0.733243 (rank : 8)
Query Neighborhood Hits	23	Target Neighborhood Hits	249	Shared Neighborhood Hits	9
SwissProt Accessions	Q8R4P4	Gene names	Tmc2
Domain Architecture	No domain graphic available
Description	Transmembrane cochlear-expressed protein 2.

TMC1_HUMAN
θ value	2.34606e-32 (rank : 5)	NC score	0.756355 (rank : 5)
Query Neighborhood Hits	23	Target Neighborhood Hits	125	Shared Neighborhood Hits	8
SwissProt Accessions	Q8TDI8	Gene names	TMC1
Domain Architecture	No domain graphic available
Description	Transmembrane cochlear-expressed protein 1.

TMC1_MOUSE
θ value	2.34606e-32 (rank : 6)	NC score	0.765412 (rank : 3)
Query Neighborhood Hits	23	Target Neighborhood Hits	83	Shared Neighborhood Hits	8
SwissProt Accessions	Q8R4P5, Q9D435	Gene names	Tmc1, Bth, dn
Domain Architecture	No domain graphic available
Description	Transmembrane cochlear-expressed protein 1 (Beethoven protein) (Deafness protein).

TMC6_MOUSE
θ value	1.4233e-29 (rank : 7)	NC score	0.751073 (rank : 7)
Query Neighborhood Hits	23	Target Neighborhood Hits	15	Shared Neighborhood Hits	8
SwissProt Accessions	Q7TN60, Q78JR7, Q7TQ68, Q8BP52, Q8C6Z5, Q99J32	Gene names	Tmc6
Domain Architecture	No domain graphic available
Description	Transmembrane channel-like protein 6.

TMC6_HUMAN
θ value	2.27234e-27 (rank : 8)	NC score	0.752474 (rank : 6)
Query Neighborhood Hits	23	Target Neighborhood Hits	12	Shared Neighborhood Hits	8
SwissProt Accessions	Q7Z403, O43284, Q45VJ2, Q8IU98, Q8IWU8, Q8TEQ7, Q9HAG5	Gene names	TMC6, EVER1, EVIN1
Domain Architecture	No domain graphic available
Description	Transmembrane channel-like protein 6 (Epidermodysplasia verruciformis protein 1) (Protein LAK-4).

GNAS1_MOUSE
θ value	0.0736092 (rank : 9)	NC score	0.021344 (rank : 11)
Query Neighborhood Hits	23	Target Neighborhood Hits	651	Shared Neighborhood Hits	6
SwissProt Accessions	Q6R0H7, Q6R0H4, Q6R0H5, Q6R2J5, Q9JJX0, Q9Z1N8	Gene names	Gnas, Gnas1
Domain Architecture	No domain graphic available
Description	Guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas (Adenylate cyclase-stimulating G alpha protein) (Extra large alphas protein) (XLalphas).

ZN385_HUMAN
θ value	0.0736092 (rank : 10)	NC score	0.041016 (rank : 10)
Query Neighborhood Hits	23	Target Neighborhood Hits	614	Shared Neighborhood Hits	7
SwissProt Accessions	Q96PM9, Q5VH53, Q9H7R6, Q9UFU3	Gene names	ZNF385, HZF, RZF
Domain Architecture
Description	Zinc finger protein 385 (Hematopoietic zinc finger protein) (Retinal zinc finger protein).

RP3A_MOUSE
θ value	0.365318 (rank : 11)	NC score	0.017391 (rank : 15)
Query Neighborhood Hits	23	Target Neighborhood Hits	510	Shared Neighborhood Hits	6
SwissProt Accessions	P47708	Gene names	Rph3a
Domain Architecture
Description	Rabphilin-3A (Exophilin-1).

PER1_MOUSE
θ value	1.06291 (rank : 12)	NC score	0.020342 (rank : 12)
Query Neighborhood Hits	23	Target Neighborhood Hits	235	Shared Neighborhood Hits	4
SwissProt Accessions	O35973	Gene names	Per1, Per, Rigui
Domain Architecture
Description	Period circadian protein 1 (Circadian pacemaker protein Rigui) (mPER) (M-Rigui).

CIKS_HUMAN
θ value	1.38821 (rank : 13)	NC score	0.042591 (rank : 9)
Query Neighborhood Hits	23	Target Neighborhood Hits	60	Shared Neighborhood Hits	2
SwissProt Accessions	O43734, Q5R3A3, Q9H5W2, Q9H6Y3, Q9NS14, Q9UG72	Gene names	TRAF3IP2, C6orf4, C6orf5
Domain Architecture	No domain graphic available
Description	Adapter protein CIKS (Connection to IKK and SAPK/JNK) (TRAF3- interacting protein 2) (Nuclear factor NF-kappa-B activator 1) (ACT1).

SON_HUMAN
θ value	1.38821 (rank : 14)	NC score	0.017708 (rank : 14)
Query Neighborhood Hits	23	Target Neighborhood Hits	1568	Shared Neighborhood Hits	13
SwissProt Accessions	P18583, O14487, O95981, Q14120, Q9H7B1, Q9P070, Q9P072, Q9UKP9, Q9UPY0	Gene names	SON, C21orf50, DBP5, KIAA1019, NREBP
Domain Architecture
Description	SON protein (SON3) (Negative regulatory element-binding protein) (NRE- binding protein) (DBP-5) (Bax antagonist selected in saccharomyces 1) (BASS1).

WNK4_HUMAN
θ value	1.81305 (rank : 15)	NC score	0.003813 (rank : 21)
Query Neighborhood Hits	23	Target Neighborhood Hits	1043	Shared Neighborhood Hits	5
SwissProt Accessions	Q96J92, Q8N8X3, Q8N8Z2, Q96DT8, Q9BYS5	Gene names	WNK4, PRKWNK4
Domain Architecture
Description	Serine/threonine-protein kinase WNK4 (EC 2.7.11.1) (Protein kinase with no lysine 4) (Protein kinase, lysine-deficient 4).

JIP2_HUMAN
θ value	2.36792 (rank : 16)	NC score	0.019527 (rank : 13)
Query Neighborhood Hits	23	Target Neighborhood Hits	288	Shared Neighborhood Hits	3
SwissProt Accessions	Q13387, Q96G62, Q99771, Q9NZ59, Q9UKQ4	Gene names	MAPK8IP2, IB2, JIP2
Domain Architecture
Description	C-jun-amino-terminal kinase-interacting protein 2 (JNK-interacting protein 2) (JIP-2) (JNK MAP kinase scaffold protein 2) (Islet-brain-2) (IB-2) (Mitogen-activated protein kinase 8-interacting protein 2).

AMOT_HUMAN
θ value	4.03905 (rank : 17)	NC score	0.010736 (rank : 18)
Query Neighborhood Hits	23	Target Neighborhood Hits	712	Shared Neighborhood Hits	3
SwissProt Accessions	Q4VCS5, Q504X5, Q9HD27, Q9UPT1	Gene names	AMOT, KIAA1071
Domain Architecture	No domain graphic available
Description	Angiomotin.

BNIPL_MOUSE
θ value	4.03905 (rank : 18)	NC score	0.014689 (rank : 16)
Query Neighborhood Hits	23	Target Neighborhood Hits	13	Shared Neighborhood Hits	2
SwissProt Accessions	Q99JU7, Q923E3	Gene names	Bnipl
Domain Architecture	No domain graphic available
Description	Bcl-2/adenovirus E1B 19 kDa-interacting protein 2-like protein.

CONA1_MOUSE
θ value	4.03905 (rank : 19)	NC score	0.010163 (rank : 19)
Query Neighborhood Hits	23	Target Neighborhood Hits	254	Shared Neighborhood Hits	7
SwissProt Accessions	Q8K4G2, Q5SUQ0	Gene names	Col23a1
Domain Architecture	No domain graphic available
Description	Collagen alpha-1(XXIII) chain.

NOTC3_HUMAN
θ value	6.88961 (rank : 20)	NC score	0.001768 (rank : 23)
Query Neighborhood Hits	23	Target Neighborhood Hits	1062	Shared Neighborhood Hits	8
SwissProt Accessions	Q9UM47, Q9UEB3, Q9UPL3, Q9Y6L8	Gene names	NOTCH3
Domain Architecture
Description	Neurogenic locus notch homolog protein 3 precursor (Notch 3) [Contains: Notch 3 extracellular truncation; Notch 3 intracellular domain].

TNFL6_HUMAN
θ value	6.88961 (rank : 21)	NC score	0.014398 (rank : 17)
Query Neighborhood Hits	23	Target Neighborhood Hits	50	Shared Neighborhood Hits	3
SwissProt Accessions	P48023, Q9BZP9	Gene names	FASLG, APT1LG1, FASL, TNFSF6
Domain Architecture
Description	Tumor necrosis factor ligand superfamily member 6 (Fas antigen ligand) (Fas ligand) (CD178 antigen) (CD95L protein) (Apoptosis antigen ligand) (APTL) [Contains: Tumor necrosis factor ligand superfamily member 6, membrane form; Tumor necrosis factor ligand superfamily member 6, soluble form].

COHA1_HUMAN
θ value	8.99809 (rank : 22)	NC score	0.009482 (rank : 20)
Query Neighborhood Hits	23	Target Neighborhood Hits	400	Shared Neighborhood Hits	7
SwissProt Accessions	Q9UMD9, Q02802, Q99018, Q9NQK9, Q9UC14	Gene names	COL17A1, BP180, BPAG2
Domain Architecture	No domain graphic available
Description	Collagen alpha-1(XVII) chain (Bullous pemphigoid antigen 2) (180 kDa bullous pemphigoid antigen 2).

LAMB3_HUMAN
θ value	8.99809 (rank : 23)	NC score	0.003670 (rank : 22)
Query Neighborhood Hits	23	Target Neighborhood Hits	461	Shared Neighborhood Hits	3
SwissProt Accessions	Q13751, O14947, Q14733, Q9UJK4, Q9UJL1	Gene names	LAMB3
Domain Architecture
Description	Laminin beta-3 chain precursor (Laminin 5 beta 3) (Laminin B1k chain) (Kalinin B1 chain).

Hits sorted by NC score

TMC8_HUMAN
NC score	0.999962 (rank : 1)	θ value	0 (rank : 1)
Query Neighborhood Hits	23	Target Neighborhood Hits	23	Shared Neighborhood Hits	23
SwissProt Accessions	Q8IU68, Q8IWU7, Q8N358, Q8NF04	Gene names	TMC8, EVER2, EVIN2
Domain Architecture	No domain graphic available
Description	Transmembrane channel-like protein 8 (Epidermodysplasia verruciformis protein 2).

TMC8_MOUSE
NC score	0.994256 (rank : 2)	θ value	0 (rank : 2)
Query Neighborhood Hits	23	Target Neighborhood Hits	11	Shared Neighborhood Hits	8
SwissProt Accessions	Q7TN58, Q3TAL0, Q3UWI0, Q7TQ67	Gene names	Tmc8, Ever2
Domain Architecture	No domain graphic available
Description	Transmembrane channel-like protein 8 (Epidermodysplasia verruciformis protein 2 homolog).

TMC1_MOUSE
NC score	0.765412 (rank : 3)	θ value	2.34606e-32 (rank : 6)
Query Neighborhood Hits	23	Target Neighborhood Hits	83	Shared Neighborhood Hits	8
SwissProt Accessions	Q8R4P5, Q9D435	Gene names	Tmc1, Bth, dn
Domain Architecture	No domain graphic available
Description	Transmembrane cochlear-expressed protein 1 (Beethoven protein) (Deafness protein).

TMC2_HUMAN
NC score	0.758635 (rank : 4)	θ value	9.52487e-34 (rank : 3)
Query Neighborhood Hits	23	Target Neighborhood Hits	149	Shared Neighborhood Hits	8
SwissProt Accessions	Q8TDI7, Q5JXT0, Q5JXT1, Q6UWW4, Q6ZS41, Q8N9F3, Q9BYN2, Q9BYN3, Q9BYN4, Q9BYN5	Gene names	TMC2
Domain Architecture	No domain graphic available
Description	Transmembrane cochlear-expressed protein 2.

TMC1_HUMAN
NC score	0.756355 (rank : 5)	θ value	2.34606e-32 (rank : 5)
Query Neighborhood Hits	23	Target Neighborhood Hits	125	Shared Neighborhood Hits	8
SwissProt Accessions	Q8TDI8	Gene names	TMC1
Domain Architecture	No domain graphic available
Description	Transmembrane cochlear-expressed protein 1.

TMC6_HUMAN
NC score	0.752474 (rank : 6)	θ value	2.27234e-27 (rank : 8)
Query Neighborhood Hits	23	Target Neighborhood Hits	12	Shared Neighborhood Hits	8
SwissProt Accessions	Q7Z403, O43284, Q45VJ2, Q8IU98, Q8IWU8, Q8TEQ7, Q9HAG5	Gene names	TMC6, EVER1, EVIN1
Domain Architecture	No domain graphic available
Description	Transmembrane channel-like protein 6 (Epidermodysplasia verruciformis protein 1) (Protein LAK-4).

TMC6_MOUSE
NC score	0.751073 (rank : 7)	θ value	1.4233e-29 (rank : 7)
Query Neighborhood Hits	23	Target Neighborhood Hits	15	Shared Neighborhood Hits	8
SwissProt Accessions	Q7TN60, Q78JR7, Q7TQ68, Q8BP52, Q8C6Z5, Q99J32	Gene names	Tmc6
Domain Architecture	No domain graphic available
Description	Transmembrane channel-like protein 6.

TMC2_MOUSE
NC score	0.733243 (rank : 8)	θ value	1.24399e-33 (rank : 4)
Query Neighborhood Hits	23	Target Neighborhood Hits	249	Shared Neighborhood Hits	9
SwissProt Accessions	Q8R4P4	Gene names	Tmc2
Domain Architecture	No domain graphic available
Description	Transmembrane cochlear-expressed protein 2.

CIKS_HUMAN
NC score	0.042591 (rank : 9)	θ value	1.38821 (rank : 13)
Query Neighborhood Hits	23	Target Neighborhood Hits	60	Shared Neighborhood Hits	2
SwissProt Accessions	O43734, Q5R3A3, Q9H5W2, Q9H6Y3, Q9NS14, Q9UG72	Gene names	TRAF3IP2, C6orf4, C6orf5
Domain Architecture	No domain graphic available
Description	Adapter protein CIKS (Connection to IKK and SAPK/JNK) (TRAF3- interacting protein 2) (Nuclear factor NF-kappa-B activator 1) (ACT1).

ZN385_HUMAN
NC score	0.041016 (rank : 10)	θ value	0.0736092 (rank : 10)
Query Neighborhood Hits	23	Target Neighborhood Hits	614	Shared Neighborhood Hits	7
SwissProt Accessions	Q96PM9, Q5VH53, Q9H7R6, Q9UFU3	Gene names	ZNF385, HZF, RZF
Domain Architecture
Description	Zinc finger protein 385 (Hematopoietic zinc finger protein) (Retinal zinc finger protein).

GNAS1_MOUSE
NC score	0.021344 (rank : 11)	θ value	0.0736092 (rank : 9)
Query Neighborhood Hits	23	Target Neighborhood Hits	651	Shared Neighborhood Hits	6
SwissProt Accessions	Q6R0H7, Q6R0H4, Q6R0H5, Q6R2J5, Q9JJX0, Q9Z1N8	Gene names	Gnas, Gnas1
Domain Architecture	No domain graphic available
Description	Guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas (Adenylate cyclase-stimulating G alpha protein) (Extra large alphas protein) (XLalphas).

PER1_MOUSE
NC score	0.020342 (rank : 12)	θ value	1.06291 (rank : 12)
Query Neighborhood Hits	23	Target Neighborhood Hits	235	Shared Neighborhood Hits	4
SwissProt Accessions	O35973	Gene names	Per1, Per, Rigui
Domain Architecture
Description	Period circadian protein 1 (Circadian pacemaker protein Rigui) (mPER) (M-Rigui).

JIP2_HUMAN
NC score	0.019527 (rank : 13)	θ value	2.36792 (rank : 16)
Query Neighborhood Hits	23	Target Neighborhood Hits	288	Shared Neighborhood Hits	3
SwissProt Accessions	Q13387, Q96G62, Q99771, Q9NZ59, Q9UKQ4	Gene names	MAPK8IP2, IB2, JIP2
Domain Architecture
Description	C-jun-amino-terminal kinase-interacting protein 2 (JNK-interacting protein 2) (JIP-2) (JNK MAP kinase scaffold protein 2) (Islet-brain-2) (IB-2) (Mitogen-activated protein kinase 8-interacting protein 2).

SON_HUMAN
NC score	0.017708 (rank : 14)	θ value	1.38821 (rank : 14)
Query Neighborhood Hits	23	Target Neighborhood Hits	1568	Shared Neighborhood Hits	13
SwissProt Accessions	P18583, O14487, O95981, Q14120, Q9H7B1, Q9P070, Q9P072, Q9UKP9, Q9UPY0	Gene names	SON, C21orf50, DBP5, KIAA1019, NREBP
Domain Architecture
Description	SON protein (SON3) (Negative regulatory element-binding protein) (NRE- binding protein) (DBP-5) (Bax antagonist selected in saccharomyces 1) (BASS1).

RP3A_MOUSE
NC score	0.017391 (rank : 15)	θ value	0.365318 (rank : 11)
Query Neighborhood Hits	23	Target Neighborhood Hits	510	Shared Neighborhood Hits	6
SwissProt Accessions	P47708	Gene names	Rph3a
Domain Architecture
Description	Rabphilin-3A (Exophilin-1).

BNIPL_MOUSE
NC score	0.014689 (rank : 16)	θ value	4.03905 (rank : 18)
Query Neighborhood Hits	23	Target Neighborhood Hits	13	Shared Neighborhood Hits	2
SwissProt Accessions	Q99JU7, Q923E3	Gene names	Bnipl
Domain Architecture	No domain graphic available
Description	Bcl-2/adenovirus E1B 19 kDa-interacting protein 2-like protein.

TNFL6_HUMAN
NC score	0.014398 (rank : 17)	θ value	6.88961 (rank : 21)
Query Neighborhood Hits	23	Target Neighborhood Hits	50	Shared Neighborhood Hits	3
SwissProt Accessions	P48023, Q9BZP9	Gene names	FASLG, APT1LG1, FASL, TNFSF6
Domain Architecture
Description	Tumor necrosis factor ligand superfamily member 6 (Fas antigen ligand) (Fas ligand) (CD178 antigen) (CD95L protein) (Apoptosis antigen ligand) (APTL) [Contains: Tumor necrosis factor ligand superfamily member 6, membrane form; Tumor necrosis factor ligand superfamily member 6, soluble form].

AMOT_HUMAN
NC score	0.010736 (rank : 18)	θ value	4.03905 (rank : 17)
Query Neighborhood Hits	23	Target Neighborhood Hits	712	Shared Neighborhood Hits	3
SwissProt Accessions	Q4VCS5, Q504X5, Q9HD27, Q9UPT1	Gene names	AMOT, KIAA1071
Domain Architecture	No domain graphic available
Description	Angiomotin.

CONA1_MOUSE
NC score	0.010163 (rank : 19)	θ value	4.03905 (rank : 19)
Query Neighborhood Hits	23	Target Neighborhood Hits	254	Shared Neighborhood Hits	7
SwissProt Accessions	Q8K4G2, Q5SUQ0	Gene names	Col23a1
Domain Architecture	No domain graphic available
Description	Collagen alpha-1(XXIII) chain.

COHA1_HUMAN
NC score	0.009482 (rank : 20)	θ value	8.99809 (rank : 22)
Query Neighborhood Hits	23	Target Neighborhood Hits	400	Shared Neighborhood Hits	7
SwissProt Accessions	Q9UMD9, Q02802, Q99018, Q9NQK9, Q9UC14	Gene names	COL17A1, BP180, BPAG2
Domain Architecture	No domain graphic available
Description	Collagen alpha-1(XVII) chain (Bullous pemphigoid antigen 2) (180 kDa bullous pemphigoid antigen 2).

WNK4_HUMAN
NC score	0.003813 (rank : 21)	θ value	1.81305 (rank : 15)
Query Neighborhood Hits	23	Target Neighborhood Hits	1043	Shared Neighborhood Hits	5
SwissProt Accessions	Q96J92, Q8N8X3, Q8N8Z2, Q96DT8, Q9BYS5	Gene names	WNK4, PRKWNK4
Domain Architecture
Description	Serine/threonine-protein kinase WNK4 (EC 2.7.11.1) (Protein kinase with no lysine 4) (Protein kinase, lysine-deficient 4).

LAMB3_HUMAN
NC score	0.003670 (rank : 22)	θ value	8.99809 (rank : 23)
Query Neighborhood Hits	23	Target Neighborhood Hits	461	Shared Neighborhood Hits	3
SwissProt Accessions	Q13751, O14947, Q14733, Q9UJK4, Q9UJL1	Gene names	LAMB3
Domain Architecture
Description	Laminin beta-3 chain precursor (Laminin 5 beta 3) (Laminin B1k chain) (Kalinin B1 chain).

NOTC3_HUMAN
NC score	0.001768 (rank : 23)	θ value	6.88961 (rank : 20)
Query Neighborhood Hits	23	Target Neighborhood Hits	1062	Shared Neighborhood Hits	8
SwissProt Accessions	Q9UM47, Q9UEB3, Q9UPL3, Q9Y6L8	Gene names	NOTCH3
Domain Architecture
Description	Neurogenic locus notch homolog protein 3 precursor (Notch 3) [Contains: Notch 3 extracellular truncation; Notch 3 intracellular domain].