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Network neighborhood for query Sequence : SYS_HUMAN

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SYS_HUMAN
SwissProt Accessions	P49591, Q9NSE3	Gene names	SARS, SERS
Domain Architecture
Description	Seryl-tRNA synthetase (EC 6.1.1.11) (Serine--tRNA ligase) (SerRS).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

SYS_HUMAN
θ value	0 (rank : 1)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	17	Target Neighborhood Hits	17	Shared Neighborhood Hits	17
SwissProt Accessions	P49591, Q9NSE3	Gene names	SARS, SERS
Domain Architecture
Description	Seryl-tRNA synthetase (EC 6.1.1.11) (Serine--tRNA ligase) (SerRS).

SYS_MOUSE
θ value	0 (rank : 2)	NC score	0.997352 (rank : 2)
Query Neighborhood Hits	17	Target Neighborhood Hits	13	Shared Neighborhood Hits	10
SwissProt Accessions	P26638	Gene names	Sars, Sars1, Sers
Domain Architecture
Description	Seryl-tRNA synthetase (EC 6.1.1.11) (Serine--tRNA ligase) (SerRS).

SYSM_HUMAN
θ value	1.62093e-41 (rank : 3)	NC score	0.800470 (rank : 4)
Query Neighborhood Hits	17	Target Neighborhood Hits	32	Shared Neighborhood Hits	4
SwissProt Accessions	Q9NP81, Q9BVP3	Gene names	SARS2, SARSM
Domain Architecture
Description	Seryl-tRNA synthetase, mitochondrial precursor (EC 6.1.1.11) (Serine-- tRNA ligase) (SerRSmt).

SYSM_MOUSE
θ value	2.76489e-41 (rank : 4)	NC score	0.802707 (rank : 3)
Query Neighborhood Hits	17	Target Neighborhood Hits	19	Shared Neighborhood Hits	4
SwissProt Accessions	Q9JJL8, Q9CWP1	Gene names	Sars2, Sarsm
Domain Architecture
Description	Seryl-tRNA synthetase, mitochondrial precursor (EC 6.1.1.11) (Serine-- tRNA ligase) (SerRSmt).

DHX29_HUMAN
θ value	0.365318 (rank : 5)	NC score	0.030914 (rank : 6)
Query Neighborhood Hits	17	Target Neighborhood Hits	144	Shared Neighborhood Hits	3
SwissProt Accessions	Q7Z478, O75549, Q63HN0, Q63HN3, Q8IWW2, Q8N3A1, Q9UMH2	Gene names	DHX29
Domain Architecture	No domain graphic available
Description	Putative ATP-dependent RNA helicase DHX29 (EC 3.6.1.-) (DEAH box protein 29) (Nucleic acid helicase DDXx).

NSD1_HUMAN
θ value	1.81305 (rank : 6)	NC score	0.028532 (rank : 8)
Query Neighborhood Hits	17	Target Neighborhood Hits	427	Shared Neighborhood Hits	3
SwissProt Accessions	Q96L73, Q96PD8, Q96RN7	Gene names	NSD1, ARA267
Domain Architecture
Description	Histone-lysine N-methyltransferase, H3 lysine-36 and H4 lysine-20 specific (EC 2.1.1.43) (H3-K36-HMTase) (H4-K20-HMTase) (Nuclear receptor-binding SET domain-containing protein 1) (NR-binding SET domain-containing protein) (Androgen receptor-associated coregulator 267).

ALO17_HUMAN
θ value	2.36792 (rank : 7)	NC score	0.043603 (rank : 5)
Query Neighborhood Hits	17	Target Neighborhood Hits	317	Shared Neighborhood Hits	3
SwissProt Accessions	Q9HCF4, Q69YK7, Q8IWF4, Q8IZX1, Q8IZX2, Q8N406	Gene names	KIAA1618, ALO17
Domain Architecture	No domain graphic available
Description	Protein ALO17 (ALK lymphoma oligomerization partner on chromosome 17).

LRC8A_HUMAN
θ value	2.36792 (rank : 8)	NC score	0.012970 (rank : 12)
Query Neighborhood Hits	17	Target Neighborhood Hits	274	Shared Neighborhood Hits	3
SwissProt Accessions	Q8IWT6, Q6UXM2, Q8NCI0, Q9P2B1	Gene names	LRRC8A, KIAA1437, LRRC8
Domain Architecture
Description	Leucine-rich repeat-containing protein 8A.

FMR1_HUMAN
θ value	3.0926 (rank : 9)	NC score	0.028871 (rank : 7)
Query Neighborhood Hits	17	Target Neighborhood Hits	45	Shared Neighborhood Hits	4
SwissProt Accessions	Q06787, Q16578, Q99054	Gene names	FMR1
Domain Architecture
Description	Fragile X mental retardation 1 protein (Protein FMR-1) (FMRP).

FAK2_MOUSE
θ value	4.03905 (rank : 10)	NC score	0.004918 (rank : 17)
Query Neighborhood Hits	17	Target Neighborhood Hits	851	Shared Neighborhood Hits	3
SwissProt Accessions	Q9QVP9	Gene names	Ptk2b, Fak2, Pyk2, Raftk
Domain Architecture	No domain graphic available
Description	Protein tyrosine kinase 2 beta (EC 2.7.10.2) (Focal adhesion kinase 2) (FADK 2) (Proline-rich tyrosine kinase 2) (Cell adhesion kinase beta) (CAK beta) (Calcium-dependent tyrosine kinase) (CADTK) (Related adhesion focal tyrosine kinase) (RAFTK).

LRC8A_MOUSE
θ value	4.03905 (rank : 11)	NC score	0.012057 (rank : 14)
Query Neighborhood Hits	17	Target Neighborhood Hits	274	Shared Neighborhood Hits	3
SwissProt Accessions	Q80WG5	Gene names	Lrrc8a, Lrrc8
Domain Architecture
Description	Leucine-rich repeat-containing protein 8A.

EXOS9_HUMAN
θ value	5.27518 (rank : 12)	NC score	0.018875 (rank : 11)
Query Neighborhood Hits	17	Target Neighborhood Hits	10	Shared Neighborhood Hits	2
SwissProt Accessions	Q06265, Q12883	Gene names	EXOSC9, PMSCL1
Domain Architecture
Description	Exosome complex exonuclease RRP45 (EC 3.1.13.-) (Exosome component 9) (Polymyositis/scleroderma autoantigen 1) (Autoantigen PM/Scl 1) (Polymyositis/scleroderma autoantigen 75 kDa) (PM/Scl-75) (P75 polymyositis-scleroderma overlap syndrome-associated autoantigen).

FMR1_MOUSE
θ value	5.27518 (rank : 13)	NC score	0.022064 (rank : 10)
Query Neighborhood Hits	17	Target Neighborhood Hits	47	Shared Neighborhood Hits	3
SwissProt Accessions	P35922	Gene names	Fmr1, Fmr-1
Domain Architecture
Description	Fragile X mental retardation protein 1 homolog (Protein FMR-1) (FMRP) (mFmr1p).

SM1L2_MOUSE
θ value	5.27518 (rank : 14)	NC score	0.006241 (rank : 16)
Query Neighborhood Hits	17	Target Neighborhood Hits	918	Shared Neighborhood Hits	3
SwissProt Accessions	Q920F6	Gene names	Smc1l2
Domain Architecture
Description	Structural maintenance of chromosomes 1-like 2 protein (SMC1beta protein).

ABTAP_MOUSE
θ value	6.88961 (rank : 15)	NC score	0.012947 (rank : 13)
Query Neighborhood Hits	17	Target Neighborhood Hits	381	Shared Neighborhood Hits	4
SwissProt Accessions	Q3V1V3	Gene names	Abtap
Domain Architecture	No domain graphic available
Description	ABT1-associated protein.

NBN_MOUSE
θ value	8.99809 (rank : 16)	NC score	0.028327 (rank : 9)
Query Neighborhood Hits	17	Target Neighborhood Hits	125	Shared Neighborhood Hits	4
SwissProt Accessions	Q9R207, O88981, Q3UY57, Q811I6, Q8CCY0, Q9R1X1	Gene names	Nbn, Nbs1
Domain Architecture	No domain graphic available
Description	Nibrin (Nijmegen breakage syndrome protein 1 homolog) (Cell cycle regulatory protein p95).

TEX9_MOUSE
θ value	8.99809 (rank : 17)	NC score	0.007661 (rank : 15)
Query Neighborhood Hits	17	Target Neighborhood Hits	581	Shared Neighborhood Hits	4
SwissProt Accessions	Q9D845, O54764	Gene names	Tex9
Domain Architecture	No domain graphic available
Description	Testis-expressed sequence 9 protein (Testis-specifically expressed protein 1) (Tsec-1).

Hits sorted by NC score

SYS_HUMAN
NC score	0.999962 (rank : 1)	θ value	0 (rank : 1)
Query Neighborhood Hits	17	Target Neighborhood Hits	17	Shared Neighborhood Hits	17
SwissProt Accessions	P49591, Q9NSE3	Gene names	SARS, SERS
Domain Architecture
Description	Seryl-tRNA synthetase (EC 6.1.1.11) (Serine--tRNA ligase) (SerRS).

SYS_MOUSE
NC score	0.997352 (rank : 2)	θ value	0 (rank : 2)
Query Neighborhood Hits	17	Target Neighborhood Hits	13	Shared Neighborhood Hits	10
SwissProt Accessions	P26638	Gene names	Sars, Sars1, Sers
Domain Architecture
Description	Seryl-tRNA synthetase (EC 6.1.1.11) (Serine--tRNA ligase) (SerRS).

SYSM_MOUSE
NC score	0.802707 (rank : 3)	θ value	2.76489e-41 (rank : 4)
Query Neighborhood Hits	17	Target Neighborhood Hits	19	Shared Neighborhood Hits	4
SwissProt Accessions	Q9JJL8, Q9CWP1	Gene names	Sars2, Sarsm
Domain Architecture
Description	Seryl-tRNA synthetase, mitochondrial precursor (EC 6.1.1.11) (Serine-- tRNA ligase) (SerRSmt).

SYSM_HUMAN
NC score	0.800470 (rank : 4)	θ value	1.62093e-41 (rank : 3)
Query Neighborhood Hits	17	Target Neighborhood Hits	32	Shared Neighborhood Hits	4
SwissProt Accessions	Q9NP81, Q9BVP3	Gene names	SARS2, SARSM
Domain Architecture
Description	Seryl-tRNA synthetase, mitochondrial precursor (EC 6.1.1.11) (Serine-- tRNA ligase) (SerRSmt).

ALO17_HUMAN
NC score	0.043603 (rank : 5)	θ value	2.36792 (rank : 7)
Query Neighborhood Hits	17	Target Neighborhood Hits	317	Shared Neighborhood Hits	3
SwissProt Accessions	Q9HCF4, Q69YK7, Q8IWF4, Q8IZX1, Q8IZX2, Q8N406	Gene names	KIAA1618, ALO17
Domain Architecture	No domain graphic available
Description	Protein ALO17 (ALK lymphoma oligomerization partner on chromosome 17).

DHX29_HUMAN
NC score	0.030914 (rank : 6)	θ value	0.365318 (rank : 5)
Query Neighborhood Hits	17	Target Neighborhood Hits	144	Shared Neighborhood Hits	3
SwissProt Accessions	Q7Z478, O75549, Q63HN0, Q63HN3, Q8IWW2, Q8N3A1, Q9UMH2	Gene names	DHX29
Domain Architecture	No domain graphic available
Description	Putative ATP-dependent RNA helicase DHX29 (EC 3.6.1.-) (DEAH box protein 29) (Nucleic acid helicase DDXx).

FMR1_HUMAN
NC score	0.028871 (rank : 7)	θ value	3.0926 (rank : 9)
Query Neighborhood Hits	17	Target Neighborhood Hits	45	Shared Neighborhood Hits	4
SwissProt Accessions	Q06787, Q16578, Q99054	Gene names	FMR1
Domain Architecture
Description	Fragile X mental retardation 1 protein (Protein FMR-1) (FMRP).

NSD1_HUMAN
NC score	0.028532 (rank : 8)	θ value	1.81305 (rank : 6)
Query Neighborhood Hits	17	Target Neighborhood Hits	427	Shared Neighborhood Hits	3
SwissProt Accessions	Q96L73, Q96PD8, Q96RN7	Gene names	NSD1, ARA267
Domain Architecture
Description	Histone-lysine N-methyltransferase, H3 lysine-36 and H4 lysine-20 specific (EC 2.1.1.43) (H3-K36-HMTase) (H4-K20-HMTase) (Nuclear receptor-binding SET domain-containing protein 1) (NR-binding SET domain-containing protein) (Androgen receptor-associated coregulator 267).

NBN_MOUSE
NC score	0.028327 (rank : 9)	θ value	8.99809 (rank : 16)
Query Neighborhood Hits	17	Target Neighborhood Hits	125	Shared Neighborhood Hits	4
SwissProt Accessions	Q9R207, O88981, Q3UY57, Q811I6, Q8CCY0, Q9R1X1	Gene names	Nbn, Nbs1
Domain Architecture	No domain graphic available
Description	Nibrin (Nijmegen breakage syndrome protein 1 homolog) (Cell cycle regulatory protein p95).

FMR1_MOUSE
NC score	0.022064 (rank : 10)	θ value	5.27518 (rank : 13)
Query Neighborhood Hits	17	Target Neighborhood Hits	47	Shared Neighborhood Hits	3
SwissProt Accessions	P35922	Gene names	Fmr1, Fmr-1
Domain Architecture
Description	Fragile X mental retardation protein 1 homolog (Protein FMR-1) (FMRP) (mFmr1p).

EXOS9_HUMAN
NC score	0.018875 (rank : 11)	θ value	5.27518 (rank : 12)
Query Neighborhood Hits	17	Target Neighborhood Hits	10	Shared Neighborhood Hits	2
SwissProt Accessions	Q06265, Q12883	Gene names	EXOSC9, PMSCL1
Domain Architecture
Description	Exosome complex exonuclease RRP45 (EC 3.1.13.-) (Exosome component 9) (Polymyositis/scleroderma autoantigen 1) (Autoantigen PM/Scl 1) (Polymyositis/scleroderma autoantigen 75 kDa) (PM/Scl-75) (P75 polymyositis-scleroderma overlap syndrome-associated autoantigen).

LRC8A_HUMAN
NC score	0.012970 (rank : 12)	θ value	2.36792 (rank : 8)
Query Neighborhood Hits	17	Target Neighborhood Hits	274	Shared Neighborhood Hits	3
SwissProt Accessions	Q8IWT6, Q6UXM2, Q8NCI0, Q9P2B1	Gene names	LRRC8A, KIAA1437, LRRC8
Domain Architecture
Description	Leucine-rich repeat-containing protein 8A.

ABTAP_MOUSE
NC score	0.012947 (rank : 13)	θ value	6.88961 (rank : 15)
Query Neighborhood Hits	17	Target Neighborhood Hits	381	Shared Neighborhood Hits	4
SwissProt Accessions	Q3V1V3	Gene names	Abtap
Domain Architecture	No domain graphic available
Description	ABT1-associated protein.

LRC8A_MOUSE
NC score	0.012057 (rank : 14)	θ value	4.03905 (rank : 11)
Query Neighborhood Hits	17	Target Neighborhood Hits	274	Shared Neighborhood Hits	3
SwissProt Accessions	Q80WG5	Gene names	Lrrc8a, Lrrc8
Domain Architecture
Description	Leucine-rich repeat-containing protein 8A.

TEX9_MOUSE
NC score	0.007661 (rank : 15)	θ value	8.99809 (rank : 17)
Query Neighborhood Hits	17	Target Neighborhood Hits	581	Shared Neighborhood Hits	4
SwissProt Accessions	Q9D845, O54764	Gene names	Tex9
Domain Architecture	No domain graphic available
Description	Testis-expressed sequence 9 protein (Testis-specifically expressed protein 1) (Tsec-1).

SM1L2_MOUSE
NC score	0.006241 (rank : 16)	θ value	5.27518 (rank : 14)
Query Neighborhood Hits	17	Target Neighborhood Hits	918	Shared Neighborhood Hits	3
SwissProt Accessions	Q920F6	Gene names	Smc1l2
Domain Architecture
Description	Structural maintenance of chromosomes 1-like 2 protein (SMC1beta protein).

FAK2_MOUSE
NC score	0.004918 (rank : 17)	θ value	4.03905 (rank : 10)
Query Neighborhood Hits	17	Target Neighborhood Hits	851	Shared Neighborhood Hits	3
SwissProt Accessions	Q9QVP9	Gene names	Ptk2b, Fak2, Pyk2, Raftk
Domain Architecture	No domain graphic available
Description	Protein tyrosine kinase 2 beta (EC 2.7.10.2) (Focal adhesion kinase 2) (FADK 2) (Proline-rich tyrosine kinase 2) (Cell adhesion kinase beta) (CAK beta) (Calcium-dependent tyrosine kinase) (CADTK) (Related adhesion focal tyrosine kinase) (RAFTK).