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Network neighborhood for query Sequence : RPB2_HUMAN

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RPB2_HUMAN
SwissProt Accessions	P30876, Q8IZ61	Gene names	POLR2B
Domain Architecture
Description	DNA-directed RNA polymerase II 140 kDa polypeptide (EC 2.7.7.6) (RNA polymerase II subunit 2) (RPB2).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

RPB2_HUMAN
θ value	0 (rank : 1)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	22	Target Neighborhood Hits	22	Shared Neighborhood Hits	22
SwissProt Accessions	P30876, Q8IZ61	Gene names	POLR2B
Domain Architecture
Description	DNA-directed RNA polymerase II 140 kDa polypeptide (EC 2.7.7.6) (RNA polymerase II subunit 2) (RPB2).

RPB2_MOUSE
θ value	0 (rank : 2)	NC score	0.999957 (rank : 2)
Query Neighborhood Hits	22	Target Neighborhood Hits	22	Shared Neighborhood Hits	22
SwissProt Accessions	Q8CFI7	Gene names	Polr2b
Domain Architecture	No domain graphic available
Description	DNA-directed RNA polymerase II 140 kDa polypeptide (EC 2.7.7.6) (RNA polymerase II subunit 2) (RPB2).

RPC2_HUMAN
θ value	0 (rank : 3)	NC score	0.966570 (rank : 3)
Query Neighborhood Hits	22	Target Neighborhood Hits	12	Shared Neighborhood Hits	6
SwissProt Accessions	Q9NW08, Q9NW59	Gene names	POLR3B
Domain Architecture
Description	DNA-directed RNA polymerase III subunit 127.6 kDa polypeptide (EC 2.7.7.6) (RNA polymerase III subunit 2) (RPC2).

RPC2_MOUSE
θ value	0 (rank : 4)	NC score	0.966409 (rank : 4)
Query Neighborhood Hits	22	Target Neighborhood Hits	13	Shared Neighborhood Hits	6
SwissProt Accessions	P59470, Q6NVF3	Gene names	Polr3b
Domain Architecture	No domain graphic available
Description	DNA-directed RNA polymerase III subunit 127.6 kDa polypeptide (EC 2.7.7.6) (RNA polymerase III subunit 2) (RPC2).

RPA2_MOUSE
θ value	3.78717e-107 (rank : 5)	NC score	0.906376 (rank : 5)
Query Neighborhood Hits	22	Target Neighborhood Hits	17	Shared Neighborhood Hits	6
SwissProt Accessions	P70700	Gene names	Polr1b, Rpa2, Rpo1-2
Domain Architecture
Description	DNA-directed RNA polymerase I 135 kDa polypeptide (EC 2.7.7.6) (RNA polymerase I subunit 2) (RPA135).

RPA2_HUMAN
θ value	7.14227e-106 (rank : 6)	NC score	0.905805 (rank : 6)
Query Neighborhood Hits	22	Target Neighborhood Hits	8	Shared Neighborhood Hits	6
SwissProt Accessions	Q9H9Y6, Q585T5, Q6ZRR2, Q9H9D3	Gene names	POLR1B
Domain Architecture
Description	DNA-directed RNA polymerase I 135 kDa polypeptide (EC 2.7.7.6) (RNA polymerase I subunit 2) (RPA135).

THYG_HUMAN
θ value	0.21417 (rank : 7)	NC score	0.030538 (rank : 9)
Query Neighborhood Hits	22	Target Neighborhood Hits	154	Shared Neighborhood Hits	4
SwissProt Accessions	P01266, O15274, O43899, Q15593, Q15948, Q9NYR1, Q9NYR2, Q9UMZ0, Q9UNY3	Gene names	TG
Domain Architecture
Description	Thyroglobulin precursor.

DYH5_HUMAN
θ value	1.06291 (rank : 8)	NC score	0.025090 (rank : 13)
Query Neighborhood Hits	22	Target Neighborhood Hits	323	Shared Neighborhood Hits	5
SwissProt Accessions	Q8TE73, Q92860, Q96L74, Q9H5S7, Q9HCG9	Gene names	DNAH5, DNAHC5, KIAA1603
Domain Architecture	No domain graphic available
Description	Ciliary dynein heavy chain 5 (Axonemal beta dynein heavy chain 5) (HL1).

CCD46_MOUSE
θ value	1.38821 (rank : 9)	NC score	0.008066 (rank : 20)
Query Neighborhood Hits	22	Target Neighborhood Hits	1405	Shared Neighborhood Hits	7
SwissProt Accessions	Q5PR68, Q80ZN6, Q99JS4, Q9D9T1	Gene names	Ccdc46
Domain Architecture	No domain graphic available
Description	Coiled coil domain-containing protein 46.

BCKD_MOUSE
θ value	1.81305 (rank : 10)	NC score	0.034093 (rank : 7)
Query Neighborhood Hits	22	Target Neighborhood Hits	15	Shared Neighborhood Hits	4
SwissProt Accessions	O55028	Gene names	Bckdk
Domain Architecture
Description	[3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial precursor (EC 2.7.11.4) (Branched-chain alpha-ketoacid dehydrogenase kinase) (BCKDHKIN) (BCKD-kinase).

BCKD_HUMAN
θ value	2.36792 (rank : 11)	NC score	0.032146 (rank : 8)
Query Neighborhood Hits	22	Target Neighborhood Hits	15	Shared Neighborhood Hits	4
SwissProt Accessions	O14874, Q96IN5	Gene names	BCKDK
Domain Architecture
Description	[3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial precursor (EC 2.7.11.4) (Branched-chain alpha-ketoacid dehydrogenase kinase) (BCKDHKIN) (BCKD-kinase).

TNR8_HUMAN
θ value	4.03905 (rank : 12)	NC score	0.022102 (rank : 14)
Query Neighborhood Hits	22	Target Neighborhood Hits	198	Shared Neighborhood Hits	4
SwissProt Accessions	P28908	Gene names	TNFRSF8, CD30
Domain Architecture
Description	Tumor necrosis factor receptor superfamily member 8 precursor (CD30L receptor) (Lymphocyte activation antigen CD30) (KI-1 antigen).

DYHC_HUMAN
θ value	5.27518 (rank : 13)	NC score	0.014847 (rank : 15)
Query Neighborhood Hits	22	Target Neighborhood Hits	733	Shared Neighborhood Hits	7
SwissProt Accessions	Q14204, Q6DKQ7, Q8WU28, Q92814, Q9Y4G5	Gene names	DYNC1H1, DNCH1, DNECL, KIAA0325
Domain Architecture	No domain graphic available
Description	Dynein heavy chain, cytosolic (DYHC) (Cytoplasmic dynein heavy chain 1) (DHC1) (Dynein heavy chain 1, cytoplasmic 1).

HEPH_HUMAN
θ value	5.27518 (rank : 14)	NC score	0.013289 (rank : 17)
Query Neighborhood Hits	22	Target Neighborhood Hits	19	Shared Neighborhood Hits	3
SwissProt Accessions	Q9BQS7, O75180, Q6UW45, Q9C058	Gene names	HEPH, KIAA0698
Domain Architecture	No domain graphic available
Description	Hephaestin precursor (EC 1.-.-.-).

LAMC2_HUMAN
θ value	5.27518 (rank : 15)	NC score	0.006613 (rank : 22)
Query Neighborhood Hits	22	Target Neighborhood Hits	715	Shared Neighborhood Hits	7
SwissProt Accessions	Q13753, Q02536, Q02537, Q13752, Q14941, Q5VYE8	Gene names	LAMC2
Domain Architecture
Description	Laminin gamma-2 chain precursor (Laminin 5 gamma 2 subunit) (Kalinin/nicein/epiligrin 100 kDa subunit) (Laminin B2t chain) (Cell- scattering factor 140 kDa subunit) (CSF 140 kDa subunit) (Large adhesive scatter factor 140 kDa subunit) (Ladsin 140 kDa subunit).

ARPC2_HUMAN
θ value	6.88961 (rank : 16)	NC score	0.027510 (rank : 10)
Query Neighborhood Hits	22	Target Neighborhood Hits	6	Shared Neighborhood Hits	4
SwissProt Accessions	O15144, Q92801, Q9P1D4	Gene names	ARPC2, ARC34
Domain Architecture
Description	Actin-related protein 2/3 complex subunit 2 (ARP2/3 complex 34 kDa subunit) (p34-ARC).

ARPC2_MOUSE
θ value	6.88961 (rank : 17)	NC score	0.027507 (rank : 11)
Query Neighborhood Hits	22	Target Neighborhood Hits	6	Shared Neighborhood Hits	4
SwissProt Accessions	Q9CVB6, Q3U870	Gene names	Arpc2
Domain Architecture	No domain graphic available
Description	Actin-related protein 2/3 complex subunit 2 (ARP2/3 complex 34 kDa subunit) (p34-ARC).

PCCA_HUMAN
θ value	6.88961 (rank : 18)	NC score	0.011912 (rank : 18)
Query Neighborhood Hits	22	Target Neighborhood Hits	22	Shared Neighborhood Hits	3
SwissProt Accessions	P05165, Q15979	Gene names	PCCA
Domain Architecture
Description	Propionyl-CoA carboxylase alpha chain, mitochondrial precursor (EC 6.4.1.3) (PCCase subunit alpha) (Propanoyl-CoA:carbon dioxide ligase subunit alpha).

RIMB1_HUMAN
θ value	6.88961 (rank : 19)	NC score	0.006703 (rank : 21)
Query Neighborhood Hits	22	Target Neighborhood Hits	1479	Shared Neighborhood Hits	7
SwissProt Accessions	O95153, O75111, Q8N5W3	Gene names	BZRAP1, KIAA0612, RBP1
Domain Architecture
Description	Peripheral-type benzodiazepine receptor-associated protein 1 (PRAX-1) (Peripheral benzodiazepine receptor-interacting protein) (PBR-IP) (RIM-binding protein 1) (RIM-BP1).

SETX_HUMAN
θ value	6.88961 (rank : 20)	NC score	0.013625 (rank : 16)
Query Neighborhood Hits	22	Target Neighborhood Hits	368	Shared Neighborhood Hits	5
SwissProt Accessions	Q7Z333, O75120, Q3KQX4, Q68DW5, Q6AZD7, Q7Z3J6, Q8WX33, Q9H9D1, Q9NVP9	Gene names	SETX, ALS4, KIAA0625, SCAR1
Domain Architecture
Description	Probable helicase senataxin (EC 3.6.1.-) (SEN1 homolog).

JOSD3_HUMAN
θ value	8.99809 (rank : 21)	NC score	0.025537 (rank : 12)
Query Neighborhood Hits	22	Target Neighborhood Hits	13	Shared Neighborhood Hits	3
SwissProt Accessions	Q9H5J8, Q6I9Y6	Gene names	JOSD3
Domain Architecture	No domain graphic available
Description	Protein JOSD3.

PGH1_MOUSE
θ value	8.99809 (rank : 22)	NC score	0.010364 (rank : 19)
Query Neighborhood Hits	22	Target Neighborhood Hits	100	Shared Neighborhood Hits	3
SwissProt Accessions	P22437	Gene names	Ptgs1, Cox-1, Cox1
Domain Architecture
Description	Prostaglandin G/H synthase 1 precursor (EC 1.14.99.1) (Cyclooxygenase- 1) (COX-1) (Prostaglandin-endoperoxide synthase 1) (Prostaglandin H2 synthase 1) (PGH synthase 1) (PGHS-1) (PHS 1).

Hits sorted by NC score

RPB2_HUMAN
NC score	0.999962 (rank : 1)	θ value	0 (rank : 1)
Query Neighborhood Hits	22	Target Neighborhood Hits	22	Shared Neighborhood Hits	22
SwissProt Accessions	P30876, Q8IZ61	Gene names	POLR2B
Domain Architecture
Description	DNA-directed RNA polymerase II 140 kDa polypeptide (EC 2.7.7.6) (RNA polymerase II subunit 2) (RPB2).

RPB2_MOUSE
NC score	0.999957 (rank : 2)	θ value	0 (rank : 2)
Query Neighborhood Hits	22	Target Neighborhood Hits	22	Shared Neighborhood Hits	22
SwissProt Accessions	Q8CFI7	Gene names	Polr2b
Domain Architecture	No domain graphic available
Description	DNA-directed RNA polymerase II 140 kDa polypeptide (EC 2.7.7.6) (RNA polymerase II subunit 2) (RPB2).

RPC2_HUMAN
NC score	0.966570 (rank : 3)	θ value	0 (rank : 3)
Query Neighborhood Hits	22	Target Neighborhood Hits	12	Shared Neighborhood Hits	6
SwissProt Accessions	Q9NW08, Q9NW59	Gene names	POLR3B
Domain Architecture
Description	DNA-directed RNA polymerase III subunit 127.6 kDa polypeptide (EC 2.7.7.6) (RNA polymerase III subunit 2) (RPC2).

RPC2_MOUSE
NC score	0.966409 (rank : 4)	θ value	0 (rank : 4)
Query Neighborhood Hits	22	Target Neighborhood Hits	13	Shared Neighborhood Hits	6
SwissProt Accessions	P59470, Q6NVF3	Gene names	Polr3b
Domain Architecture	No domain graphic available
Description	DNA-directed RNA polymerase III subunit 127.6 kDa polypeptide (EC 2.7.7.6) (RNA polymerase III subunit 2) (RPC2).

RPA2_MOUSE
NC score	0.906376 (rank : 5)	θ value	3.78717e-107 (rank : 5)
Query Neighborhood Hits	22	Target Neighborhood Hits	17	Shared Neighborhood Hits	6
SwissProt Accessions	P70700	Gene names	Polr1b, Rpa2, Rpo1-2
Domain Architecture
Description	DNA-directed RNA polymerase I 135 kDa polypeptide (EC 2.7.7.6) (RNA polymerase I subunit 2) (RPA135).

RPA2_HUMAN
NC score	0.905805 (rank : 6)	θ value	7.14227e-106 (rank : 6)
Query Neighborhood Hits	22	Target Neighborhood Hits	8	Shared Neighborhood Hits	6
SwissProt Accessions	Q9H9Y6, Q585T5, Q6ZRR2, Q9H9D3	Gene names	POLR1B
Domain Architecture
Description	DNA-directed RNA polymerase I 135 kDa polypeptide (EC 2.7.7.6) (RNA polymerase I subunit 2) (RPA135).

BCKD_MOUSE
NC score	0.034093 (rank : 7)	θ value	1.81305 (rank : 10)
Query Neighborhood Hits	22	Target Neighborhood Hits	15	Shared Neighborhood Hits	4
SwissProt Accessions	O55028	Gene names	Bckdk
Domain Architecture
Description	[3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial precursor (EC 2.7.11.4) (Branched-chain alpha-ketoacid dehydrogenase kinase) (BCKDHKIN) (BCKD-kinase).

BCKD_HUMAN
NC score	0.032146 (rank : 8)	θ value	2.36792 (rank : 11)
Query Neighborhood Hits	22	Target Neighborhood Hits	15	Shared Neighborhood Hits	4
SwissProt Accessions	O14874, Q96IN5	Gene names	BCKDK
Domain Architecture
Description	[3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial precursor (EC 2.7.11.4) (Branched-chain alpha-ketoacid dehydrogenase kinase) (BCKDHKIN) (BCKD-kinase).

THYG_HUMAN
NC score	0.030538 (rank : 9)	θ value	0.21417 (rank : 7)
Query Neighborhood Hits	22	Target Neighborhood Hits	154	Shared Neighborhood Hits	4
SwissProt Accessions	P01266, O15274, O43899, Q15593, Q15948, Q9NYR1, Q9NYR2, Q9UMZ0, Q9UNY3	Gene names	TG
Domain Architecture
Description	Thyroglobulin precursor.

ARPC2_HUMAN
NC score	0.027510 (rank : 10)	θ value	6.88961 (rank : 16)
Query Neighborhood Hits	22	Target Neighborhood Hits	6	Shared Neighborhood Hits	4
SwissProt Accessions	O15144, Q92801, Q9P1D4	Gene names	ARPC2, ARC34
Domain Architecture
Description	Actin-related protein 2/3 complex subunit 2 (ARP2/3 complex 34 kDa subunit) (p34-ARC).

ARPC2_MOUSE
NC score	0.027507 (rank : 11)	θ value	6.88961 (rank : 17)
Query Neighborhood Hits	22	Target Neighborhood Hits	6	Shared Neighborhood Hits	4
SwissProt Accessions	Q9CVB6, Q3U870	Gene names	Arpc2
Domain Architecture	No domain graphic available
Description	Actin-related protein 2/3 complex subunit 2 (ARP2/3 complex 34 kDa subunit) (p34-ARC).

JOSD3_HUMAN
NC score	0.025537 (rank : 12)	θ value	8.99809 (rank : 21)
Query Neighborhood Hits	22	Target Neighborhood Hits	13	Shared Neighborhood Hits	3
SwissProt Accessions	Q9H5J8, Q6I9Y6	Gene names	JOSD3
Domain Architecture	No domain graphic available
Description	Protein JOSD3.

DYH5_HUMAN
NC score	0.025090 (rank : 13)	θ value	1.06291 (rank : 8)
Query Neighborhood Hits	22	Target Neighborhood Hits	323	Shared Neighborhood Hits	5
SwissProt Accessions	Q8TE73, Q92860, Q96L74, Q9H5S7, Q9HCG9	Gene names	DNAH5, DNAHC5, KIAA1603
Domain Architecture	No domain graphic available
Description	Ciliary dynein heavy chain 5 (Axonemal beta dynein heavy chain 5) (HL1).

TNR8_HUMAN
NC score	0.022102 (rank : 14)	θ value	4.03905 (rank : 12)
Query Neighborhood Hits	22	Target Neighborhood Hits	198	Shared Neighborhood Hits	4
SwissProt Accessions	P28908	Gene names	TNFRSF8, CD30
Domain Architecture
Description	Tumor necrosis factor receptor superfamily member 8 precursor (CD30L receptor) (Lymphocyte activation antigen CD30) (KI-1 antigen).

DYHC_HUMAN
NC score	0.014847 (rank : 15)	θ value	5.27518 (rank : 13)
Query Neighborhood Hits	22	Target Neighborhood Hits	733	Shared Neighborhood Hits	7
SwissProt Accessions	Q14204, Q6DKQ7, Q8WU28, Q92814, Q9Y4G5	Gene names	DYNC1H1, DNCH1, DNECL, KIAA0325
Domain Architecture	No domain graphic available
Description	Dynein heavy chain, cytosolic (DYHC) (Cytoplasmic dynein heavy chain 1) (DHC1) (Dynein heavy chain 1, cytoplasmic 1).

SETX_HUMAN
NC score	0.013625 (rank : 16)	θ value	6.88961 (rank : 20)
Query Neighborhood Hits	22	Target Neighborhood Hits	368	Shared Neighborhood Hits	5
SwissProt Accessions	Q7Z333, O75120, Q3KQX4, Q68DW5, Q6AZD7, Q7Z3J6, Q8WX33, Q9H9D1, Q9NVP9	Gene names	SETX, ALS4, KIAA0625, SCAR1
Domain Architecture
Description	Probable helicase senataxin (EC 3.6.1.-) (SEN1 homolog).

HEPH_HUMAN
NC score	0.013289 (rank : 17)	θ value	5.27518 (rank : 14)
Query Neighborhood Hits	22	Target Neighborhood Hits	19	Shared Neighborhood Hits	3
SwissProt Accessions	Q9BQS7, O75180, Q6UW45, Q9C058	Gene names	HEPH, KIAA0698
Domain Architecture	No domain graphic available
Description	Hephaestin precursor (EC 1.-.-.-).

PCCA_HUMAN
NC score	0.011912 (rank : 18)	θ value	6.88961 (rank : 18)
Query Neighborhood Hits	22	Target Neighborhood Hits	22	Shared Neighborhood Hits	3
SwissProt Accessions	P05165, Q15979	Gene names	PCCA
Domain Architecture
Description	Propionyl-CoA carboxylase alpha chain, mitochondrial precursor (EC 6.4.1.3) (PCCase subunit alpha) (Propanoyl-CoA:carbon dioxide ligase subunit alpha).

PGH1_MOUSE
NC score	0.010364 (rank : 19)	θ value	8.99809 (rank : 22)
Query Neighborhood Hits	22	Target Neighborhood Hits	100	Shared Neighborhood Hits	3
SwissProt Accessions	P22437	Gene names	Ptgs1, Cox-1, Cox1
Domain Architecture
Description	Prostaglandin G/H synthase 1 precursor (EC 1.14.99.1) (Cyclooxygenase- 1) (COX-1) (Prostaglandin-endoperoxide synthase 1) (Prostaglandin H2 synthase 1) (PGH synthase 1) (PGHS-1) (PHS 1).

CCD46_MOUSE
NC score	0.008066 (rank : 20)	θ value	1.38821 (rank : 9)
Query Neighborhood Hits	22	Target Neighborhood Hits	1405	Shared Neighborhood Hits	7
SwissProt Accessions	Q5PR68, Q80ZN6, Q99JS4, Q9D9T1	Gene names	Ccdc46
Domain Architecture	No domain graphic available
Description	Coiled coil domain-containing protein 46.

RIMB1_HUMAN
NC score	0.006703 (rank : 21)	θ value	6.88961 (rank : 19)
Query Neighborhood Hits	22	Target Neighborhood Hits	1479	Shared Neighborhood Hits	7
SwissProt Accessions	O95153, O75111, Q8N5W3	Gene names	BZRAP1, KIAA0612, RBP1
Domain Architecture
Description	Peripheral-type benzodiazepine receptor-associated protein 1 (PRAX-1) (Peripheral benzodiazepine receptor-interacting protein) (PBR-IP) (RIM-binding protein 1) (RIM-BP1).

LAMC2_HUMAN
NC score	0.006613 (rank : 22)	θ value	5.27518 (rank : 15)
Query Neighborhood Hits	22	Target Neighborhood Hits	715	Shared Neighborhood Hits	7
SwissProt Accessions	Q13753, Q02536, Q02537, Q13752, Q14941, Q5VYE8	Gene names	LAMC2
Domain Architecture
Description	Laminin gamma-2 chain precursor (Laminin 5 gamma 2 subunit) (Kalinin/nicein/epiligrin 100 kDa subunit) (Laminin B2t chain) (Cell- scattering factor 140 kDa subunit) (CSF 140 kDa subunit) (Large adhesive scatter factor 140 kDa subunit) (Ladsin 140 kDa subunit).