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Network neighborhood for query Sequence : MED8_HUMAN

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MED8_HUMAN
SwissProt Accessions	Q96G25, Q96FQ4	Gene names	MED8
Domain Architecture	No domain graphic available
Description	Mediator of RNA polymerase II transcription subunit 8 homolog (Activator-recruited cofactor 32 kDa component) (ARC32).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

MED8_HUMAN
θ value	9.58617e-127 (rank : 1)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	11	Target Neighborhood Hits	11	Shared Neighborhood Hits	11
SwissProt Accessions	Q96G25, Q96FQ4	Gene names	MED8
Domain Architecture	No domain graphic available
Description	Mediator of RNA polymerase II transcription subunit 8 homolog (Activator-recruited cofactor 32 kDa component) (ARC32).

MED8_MOUSE
θ value	1.0968e-122 (rank : 2)	NC score	0.996522 (rank : 2)
Query Neighborhood Hits	11	Target Neighborhood Hits	12	Shared Neighborhood Hits	7
SwissProt Accessions	Q9D7W5, Q3UGB4, Q99LM4, Q9JJ84	Gene names	Med8
Domain Architecture	No domain graphic available
Description	Mediator of RNA polymerase II transcription subunit 8 homolog (Activator-recruited cofactor 32 kDa component) (ARC32).

ZN683_HUMAN
θ value	1.38821 (rank : 3)	NC score	0.006128 (rank : 11)
Query Neighborhood Hits	11	Target Neighborhood Hits	750	Shared Neighborhood Hits	2
SwissProt Accessions	Q8IZ20, Q5T141, Q5T146, Q5T147, Q5T149, Q8NEN4	Gene names	ZNF683
Domain Architecture	No domain graphic available
Description	Zinc finger protein 683.

EVPL_HUMAN
θ value	1.81305 (rank : 4)	NC score	0.021653 (rank : 6)
Query Neighborhood Hits	11	Target Neighborhood Hits	895	Shared Neighborhood Hits	5
SwissProt Accessions	Q92817	Gene names	EVPL
Domain Architecture
Description	Envoplakin (210 kDa paraneoplastic pemphigus antigen) (p210) (210 kDa cornified envelope precursor protein).

RED2_MOUSE
θ value	1.81305 (rank : 5)	NC score	0.055838 (rank : 3)
Query Neighborhood Hits	11	Target Neighborhood Hits	26	Shared Neighborhood Hits	4
SwissProt Accessions	Q9JI20, Q3UTP1, Q8CC51, Q9JIE5	Gene names	Adarb2, Adar3, Red2
Domain Architecture
Description	Double-stranded RNA-specific editase B2 (EC 3.5.-.-) (dsRNA adenosine deaminase B2) (RNA-dependent adenosine deaminase 3) (RNA-editing deaminase 2) (RNA-editing enzyme 2).

CRTC1_HUMAN
θ value	6.88961 (rank : 6)	NC score	0.018725 (rank : 7)
Query Neighborhood Hits	11	Target Neighborhood Hits	319	Shared Neighborhood Hits	2
SwissProt Accessions	Q6UUV9, O75114, Q6Y3A3, Q7LDZ2, Q8IUL3, Q8IZ34, Q8IZL1, Q8N6W3, Q96AI8, Q9H801	Gene names	CRTC1, KIAA0616, MECT1, TORC1, WAMTP1
Domain Architecture	No domain graphic available
Description	CREB-regulated transcription coactivator 1 (Transducer of regulated cAMP response element-binding protein 1) (Transducer of CREB protein 1) (Mucoepidermoid carcinoma translocated protein 1).

ITSN2_HUMAN
θ value	6.88961 (rank : 7)	NC score	0.009480 (rank : 10)
Query Neighborhood Hits	11	Target Neighborhood Hits	1173	Shared Neighborhood Hits	6
SwissProt Accessions	Q9NZM3, O95062, Q15812, Q9HAK4, Q9NXE6, Q9NYG0, Q9NZM2, Q9ULG4	Gene names	ITSN2, KIAA1256, SH3D1B, SWAP
Domain Architecture
Description	Intersectin-2 (SH3 domain-containing protein 1B) (SH3P18) (SH3P18-like WASP-associated protein).

NADAP_HUMAN
θ value	6.88961 (rank : 8)	NC score	0.035799 (rank : 5)
Query Neighborhood Hits	11	Target Neighborhood Hits	208	Shared Neighborhood Hits	3
SwissProt Accessions	Q9BWU0, Q4KMT1, Q4KMX0, Q7Z5Q9, Q9NVN2	Gene names	SLC4A1AP, HLC3
Domain Architecture	No domain graphic available
Description	Kanadaptin (Kidney anion exchanger adapter protein) (Solute carrier family 4 anion exchanger member 1 adapter protein) (Lung cancer oncogene 3 protein).

PDZD2_HUMAN
θ value	6.88961 (rank : 9)	NC score	0.011631 (rank : 8)
Query Neighborhood Hits	11	Target Neighborhood Hits	772	Shared Neighborhood Hits	3
SwissProt Accessions	O15018, Q9BXD4	Gene names	PDZD2, AIPC, KIAA0300, PDZK3
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 2 (PDZ domain-containing protein 3) (Activated in prostate cancer protein).

OFD1_HUMAN
θ value	8.99809 (rank : 10)	NC score	0.009644 (rank : 9)
Query Neighborhood Hits	11	Target Neighborhood Hits	753	Shared Neighborhood Hits	4
SwissProt Accessions	O75665, O75666	Gene names	OFD1, CXorf5
Domain Architecture	No domain graphic available
Description	Oral-facial-digital syndrome 1 protein (Protein 71-7A).

RED2_HUMAN
θ value	8.99809 (rank : 11)	NC score	0.042352 (rank : 4)
Query Neighborhood Hits	11	Target Neighborhood Hits	30	Shared Neighborhood Hits	4
SwissProt Accessions	Q9NS39	Gene names	ADARB2, ADAR3, RED2
Domain Architecture
Description	Double-stranded RNA-specific editase B2 (EC 3.5.-.-) (dsRNA adenosine deaminase B2) (RNA-dependent adenosine deaminase 3) (RNA-editing deaminase 2) (RNA-editing enzyme 2).

Hits sorted by NC score

MED8_HUMAN
NC score	0.999962 (rank : 1)	θ value	9.58617e-127 (rank : 1)
Query Neighborhood Hits	11	Target Neighborhood Hits	11	Shared Neighborhood Hits	11
SwissProt Accessions	Q96G25, Q96FQ4	Gene names	MED8
Domain Architecture	No domain graphic available
Description	Mediator of RNA polymerase II transcription subunit 8 homolog (Activator-recruited cofactor 32 kDa component) (ARC32).

MED8_MOUSE
NC score	0.996522 (rank : 2)	θ value	1.0968e-122 (rank : 2)
Query Neighborhood Hits	11	Target Neighborhood Hits	12	Shared Neighborhood Hits	7
SwissProt Accessions	Q9D7W5, Q3UGB4, Q99LM4, Q9JJ84	Gene names	Med8
Domain Architecture	No domain graphic available
Description	Mediator of RNA polymerase II transcription subunit 8 homolog (Activator-recruited cofactor 32 kDa component) (ARC32).

RED2_MOUSE
NC score	0.055838 (rank : 3)	θ value	1.81305 (rank : 5)
Query Neighborhood Hits	11	Target Neighborhood Hits	26	Shared Neighborhood Hits	4
SwissProt Accessions	Q9JI20, Q3UTP1, Q8CC51, Q9JIE5	Gene names	Adarb2, Adar3, Red2
Domain Architecture
Description	Double-stranded RNA-specific editase B2 (EC 3.5.-.-) (dsRNA adenosine deaminase B2) (RNA-dependent adenosine deaminase 3) (RNA-editing deaminase 2) (RNA-editing enzyme 2).

RED2_HUMAN
NC score	0.042352 (rank : 4)	θ value	8.99809 (rank : 11)
Query Neighborhood Hits	11	Target Neighborhood Hits	30	Shared Neighborhood Hits	4
SwissProt Accessions	Q9NS39	Gene names	ADARB2, ADAR3, RED2
Domain Architecture
Description	Double-stranded RNA-specific editase B2 (EC 3.5.-.-) (dsRNA adenosine deaminase B2) (RNA-dependent adenosine deaminase 3) (RNA-editing deaminase 2) (RNA-editing enzyme 2).

NADAP_HUMAN
NC score	0.035799 (rank : 5)	θ value	6.88961 (rank : 8)
Query Neighborhood Hits	11	Target Neighborhood Hits	208	Shared Neighborhood Hits	3
SwissProt Accessions	Q9BWU0, Q4KMT1, Q4KMX0, Q7Z5Q9, Q9NVN2	Gene names	SLC4A1AP, HLC3
Domain Architecture	No domain graphic available
Description	Kanadaptin (Kidney anion exchanger adapter protein) (Solute carrier family 4 anion exchanger member 1 adapter protein) (Lung cancer oncogene 3 protein).

EVPL_HUMAN
NC score	0.021653 (rank : 6)	θ value	1.81305 (rank : 4)
Query Neighborhood Hits	11	Target Neighborhood Hits	895	Shared Neighborhood Hits	5
SwissProt Accessions	Q92817	Gene names	EVPL
Domain Architecture
Description	Envoplakin (210 kDa paraneoplastic pemphigus antigen) (p210) (210 kDa cornified envelope precursor protein).

CRTC1_HUMAN
NC score	0.018725 (rank : 7)	θ value	6.88961 (rank : 6)
Query Neighborhood Hits	11	Target Neighborhood Hits	319	Shared Neighborhood Hits	2
SwissProt Accessions	Q6UUV9, O75114, Q6Y3A3, Q7LDZ2, Q8IUL3, Q8IZ34, Q8IZL1, Q8N6W3, Q96AI8, Q9H801	Gene names	CRTC1, KIAA0616, MECT1, TORC1, WAMTP1
Domain Architecture	No domain graphic available
Description	CREB-regulated transcription coactivator 1 (Transducer of regulated cAMP response element-binding protein 1) (Transducer of CREB protein 1) (Mucoepidermoid carcinoma translocated protein 1).

PDZD2_HUMAN
NC score	0.011631 (rank : 8)	θ value	6.88961 (rank : 9)
Query Neighborhood Hits	11	Target Neighborhood Hits	772	Shared Neighborhood Hits	3
SwissProt Accessions	O15018, Q9BXD4	Gene names	PDZD2, AIPC, KIAA0300, PDZK3
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 2 (PDZ domain-containing protein 3) (Activated in prostate cancer protein).

OFD1_HUMAN
NC score	0.009644 (rank : 9)	θ value	8.99809 (rank : 10)
Query Neighborhood Hits	11	Target Neighborhood Hits	753	Shared Neighborhood Hits	4
SwissProt Accessions	O75665, O75666	Gene names	OFD1, CXorf5
Domain Architecture	No domain graphic available
Description	Oral-facial-digital syndrome 1 protein (Protein 71-7A).

ITSN2_HUMAN
NC score	0.009480 (rank : 10)	θ value	6.88961 (rank : 7)
Query Neighborhood Hits	11	Target Neighborhood Hits	1173	Shared Neighborhood Hits	6
SwissProt Accessions	Q9NZM3, O95062, Q15812, Q9HAK4, Q9NXE6, Q9NYG0, Q9NZM2, Q9ULG4	Gene names	ITSN2, KIAA1256, SH3D1B, SWAP
Domain Architecture
Description	Intersectin-2 (SH3 domain-containing protein 1B) (SH3P18) (SH3P18-like WASP-associated protein).

ZN683_HUMAN
NC score	0.006128 (rank : 11)	θ value	1.38821 (rank : 3)
Query Neighborhood Hits	11	Target Neighborhood Hits	750	Shared Neighborhood Hits	2
SwissProt Accessions	Q8IZ20, Q5T141, Q5T146, Q5T147, Q5T149, Q8NEN4	Gene names	ZNF683
Domain Architecture	No domain graphic available
Description	Zinc finger protein 683.