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Network neighborhood for query Sequence : IF2B_MOUSE

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IF2B_MOUSE
SwissProt Accessions	Q99L45, Q9CSH6, Q9CT12	Gene names	Eif2s2
Domain Architecture
Description	Eukaryotic translation initiation factor 2 subunit 2 (Eukaryotic translation initiation factor 2 subunit beta) (eIF-2-beta).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

IF2B_MOUSE
θ value	1.32529e-160 (rank : 1)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	50	Target Neighborhood Hits	50	Shared Neighborhood Hits	50
SwissProt Accessions	Q99L45, Q9CSH6, Q9CT12	Gene names	Eif2s2
Domain Architecture
Description	Eukaryotic translation initiation factor 2 subunit 2 (Eukaryotic translation initiation factor 2 subunit beta) (eIF-2-beta).

IF2B_HUMAN
θ value	1.05009e-157 (rank : 2)	NC score	0.980499 (rank : 2)
Query Neighborhood Hits	50	Target Neighborhood Hits	60	Shared Neighborhood Hits	29
SwissProt Accessions	P20042, Q9BVU0, Q9UJE4	Gene names	EIF2S2, EIF2B
Domain Architecture
Description	Eukaryotic translation initiation factor 2 subunit 2 (Eukaryotic translation initiation factor 2 subunit beta) (eIF-2-beta).

IF5_HUMAN
θ value	7.59969e-07 (rank : 3)	NC score	0.378140 (rank : 4)
Query Neighborhood Hits	50	Target Neighborhood Hits	36	Shared Neighborhood Hits	4
SwissProt Accessions	P55010, Q9H5N2, Q9UG48	Gene names	EIF5
Domain Architecture
Description	Eukaryotic translation initiation factor 5 (eIF-5).

IF5_MOUSE
θ value	7.59969e-07 (rank : 4)	NC score	0.378830 (rank : 3)
Query Neighborhood Hits	50	Target Neighborhood Hits	35	Shared Neighborhood Hits	4
SwissProt Accessions	P59325	Gene names	Eif5
Domain Architecture
Description	Eukaryotic translation initiation factor 5 (eIF-5).

POT15_HUMAN
θ value	0.0736092 (rank : 5)	NC score	0.048401 (rank : 16)
Query Neighborhood Hits	50	Target Neighborhood Hits	893	Shared Neighborhood Hits	23
SwissProt Accessions	Q6S5H4, Q6NXN7, Q6S5H7	Gene names	POTE15
Domain Architecture	No domain graphic available
Description	Prostate, ovary, testis-expressed protein on chromosome 15.

EDAR_MOUSE
θ value	0.21417 (rank : 6)	NC score	0.088892 (rank : 6)
Query Neighborhood Hits	50	Target Neighborhood Hits	66	Shared Neighborhood Hits	4
SwissProt Accessions	Q9R187, Q9DC43	Gene names	Edar, Dl
Domain Architecture
Description	Tumor necrosis factor receptor superfamily member EDAR precursor (Anhidrotic ectodysplasin receptor 1) (Ectodysplasin-A receptor) (Ectodermal dysplasia receptor) (Downless).

MAP1A_HUMAN
θ value	0.21417 (rank : 7)	NC score	0.051546 (rank : 15)
Query Neighborhood Hits	50	Target Neighborhood Hits	1626	Shared Neighborhood Hits	27
SwissProt Accessions	P78559, O95643, Q12973, Q15882, Q9UJT4	Gene names	MAP1A
Domain Architecture
Description	Microtubule-associated protein 1A (MAP 1A) (Proliferation-related protein p80) [Contains: MAP1 light chain LC2].

ANR21_HUMAN
θ value	0.365318 (rank : 8)	NC score	0.042178 (rank : 21)
Query Neighborhood Hits	50	Target Neighborhood Hits	864	Shared Neighborhood Hits	19
SwissProt Accessions	Q86YR6	Gene names	ANKRD21, POTE
Domain Architecture
Description	Ankyrin repeat domain-containing protein 21 (Protein POTE) (Prostate, ovary, testis-expressed protein).

CT2NL_HUMAN
θ value	0.365318 (rank : 9)	NC score	0.038326 (rank : 26)
Query Neighborhood Hits	50	Target Neighborhood Hits	1059	Shared Neighborhood Hits	17
SwissProt Accessions	Q9P2B4, Q96B40	Gene names	CTTNBP2NL, KIAA1433
Domain Architecture	No domain graphic available
Description	CTTNBP2 N-terminal-like protein.

GLI3_MOUSE
θ value	0.365318 (rank : 10)	NC score	0.017347 (rank : 39)
Query Neighborhood Hits	50	Target Neighborhood Hits	807	Shared Neighborhood Hits	5
SwissProt Accessions	Q61602	Gene names	Gli3
Domain Architecture	No domain graphic available
Description	Zinc finger protein GLI3.

EDAR_HUMAN
θ value	0.47712 (rank : 11)	NC score	0.084622 (rank : 7)
Query Neighborhood Hits	50	Target Neighborhood Hits	84	Shared Neighborhood Hits	4
SwissProt Accessions	Q9UNE0, Q9UND9	Gene names	EDAR, DL
Domain Architecture
Description	Tumor necrosis factor receptor superfamily member EDAR precursor (Anhidrotic ectodysplasin receptor 1) (Ectodysplasin-A receptor) (EDA- A1 receptor) (Ectodermal dysplasia receptor) (Downless homolog).

GLI3_HUMAN
θ value	0.47712 (rank : 12)	NC score	0.017142 (rank : 40)
Query Neighborhood Hits	50	Target Neighborhood Hits	871	Shared Neighborhood Hits	8
SwissProt Accessions	P10071, O75219, Q9UDT5, Q9UJ39	Gene names	GLI3
Domain Architecture	No domain graphic available
Description	Zinc finger protein GLI3.

AL2S4_MOUSE
θ value	0.62314 (rank : 13)	NC score	0.068206 (rank : 12)
Query Neighborhood Hits	50	Target Neighborhood Hits	193	Shared Neighborhood Hits	8
SwissProt Accessions	Q3V0J1, Q3TIS2	Gene names	Als2cr4
Domain Architecture	No domain graphic available
Description	Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 4 protein homolog.

FA21C_HUMAN
θ value	0.62314 (rank : 14)	NC score	0.107120 (rank : 5)
Query Neighborhood Hits	50	Target Neighborhood Hits	194	Shared Neighborhood Hits	15
SwissProt Accessions	Q9Y4E1, Q5SQU4, Q5SQU5, Q7L521, Q9UG79	Gene names	FAM21C, KIAA0592
Domain Architecture	No domain graphic available
Description	Protein FAM21C.

NAT10_HUMAN
θ value	0.813845 (rank : 15)	NC score	0.071888 (rank : 11)
Query Neighborhood Hits	50	Target Neighborhood Hits	62	Shared Neighborhood Hits	4
SwissProt Accessions	Q9H0A0, Q86WK5, Q9C0F4, Q9HA61, Q9NVF2	Gene names	NAT10, ALP, KIAA1709
Domain Architecture
Description	N-acetyltransferase 10 (EC 2.3.1.-).

TCF8_HUMAN
θ value	0.813845 (rank : 16)	NC score	0.013724 (rank : 42)
Query Neighborhood Hits	50	Target Neighborhood Hits	1057	Shared Neighborhood Hits	23
SwissProt Accessions	P37275, Q12924, Q13800	Gene names	TCF8, AREB6
Domain Architecture
Description	Transcription factor 8 (NIL-2-A zinc finger protein) (Negative regulator of IL2).

RPGR_HUMAN
θ value	1.06291 (rank : 17)	NC score	0.046165 (rank : 17)
Query Neighborhood Hits	50	Target Neighborhood Hits	279	Shared Neighborhood Hits	14
SwissProt Accessions	Q92834, O00702, O00737, Q8N5T6, Q93039, Q9HD29, Q9UMR1	Gene names	RPGR, RP3, XLRP3
Domain Architecture
Description	X-linked retinitis pigmentosa GTPase regulator.

PRPF3_MOUSE
θ value	1.38821 (rank : 18)	NC score	0.079964 (rank : 8)
Query Neighborhood Hits	50	Target Neighborhood Hits	74	Shared Neighborhood Hits	5
SwissProt Accessions	Q922U1, Q3TJH4, Q9D6C6	Gene names	Prpf3
Domain Architecture
Description	U4/U6 small nuclear ribonucleoprotein Prp3 (Pre-mRNA-splicing factor 3).

SMCA2_HUMAN
θ value	1.38821 (rank : 19)	NC score	0.016694 (rank : 41)
Query Neighborhood Hits	50	Target Neighborhood Hits	503	Shared Neighborhood Hits	12
SwissProt Accessions	P51531	Gene names	SMARCA2, BRM, SNF2A, SNF2L2
Domain Architecture
Description	Probable global transcription activator SNF2L2 (EC 3.6.1.-) (ATP- dependent helicase SMARCA2) (SNF2-alpha) (SWI/SNF-related matrix- associated actin-dependent regulator of chromatin subfamily A member 2) (hBRM).

ETV3_HUMAN
θ value	1.81305 (rank : 20)	NC score	0.018838 (rank : 38)
Query Neighborhood Hits	50	Target Neighborhood Hits	312	Shared Neighborhood Hits	4
SwissProt Accessions	P41162, Q8TAC8, Q9BX30	Gene names	ETV3, METS, PE1
Domain Architecture	No domain graphic available
Description	ETS translocation variant 3 (ETS-domain transcriptional repressor PE1) (PE-1) (Mitogenic Ets transcriptional suppressor).

PRPF3_HUMAN
θ value	1.81305 (rank : 21)	NC score	0.077393 (rank : 9)
Query Neighborhood Hits	50	Target Neighborhood Hits	65	Shared Neighborhood Hits	5
SwissProt Accessions	O43395, O43446	Gene names	PRPF3, HPRP3, PRP3
Domain Architecture
Description	U4/U6 small nuclear ribonucleoprotein Prp3 (Pre-mRNA-splicing factor 3) (U4/U6 snRNP 90 kDa protein) (hPrp3).

GAK_MOUSE
θ value	2.36792 (rank : 22)	NC score	0.005908 (rank : 49)
Query Neighborhood Hits	50	Target Neighborhood Hits	964	Shared Neighborhood Hits	3
SwissProt Accessions	Q99KY4, Q6P1I8, Q6P9S5, Q8BM74, Q8K0Q4	Gene names	Gak
Domain Architecture	No domain graphic available
Description	Cyclin G-associated kinase (EC 2.7.11.1).

PCGF6_HUMAN
θ value	2.36792 (rank : 23)	NC score	0.044261 (rank : 19)
Query Neighborhood Hits	50	Target Neighborhood Hits	178	Shared Neighborhood Hits	5
SwissProt Accessions	Q9BYE7, Q5SYD1, Q5SYD6, Q96ID9, Q96SJ1	Gene names	PCGF6, MBLR, RNF134
Domain Architecture	No domain graphic available
Description	Polycomb group RING finger protein 6 (RING finger protein 134) (Mel18 and Bmi1-like RING finger).

TR150_MOUSE
θ value	2.36792 (rank : 24)	NC score	0.040760 (rank : 23)
Query Neighborhood Hits	50	Target Neighborhood Hits	468	Shared Neighborhood Hits	17
SwissProt Accessions	Q569Z6	Gene names	Thrap3, Trap150
Domain Architecture	No domain graphic available
Description	Thyroid hormone receptor-associated protein 3 (Thyroid hormone receptor-associated protein complex 150 kDa component) (Trap150).

AN32B_MOUSE
θ value	3.0926 (rank : 25)	NC score	0.040445 (rank : 24)
Query Neighborhood Hits	50	Target Neighborhood Hits	236	Shared Neighborhood Hits	12
SwissProt Accessions	Q9EST5	Gene names	Anp32b, Pal31
Domain Architecture	No domain graphic available
Description	Acidic leucine-rich nuclear phosphoprotein 32 family member B (Proliferation-related acidic leucine-rich protein PAL31).

CT2NL_MOUSE
θ value	3.0926 (rank : 26)	NC score	0.033177 (rank : 29)
Query Neighborhood Hits	50	Target Neighborhood Hits	902	Shared Neighborhood Hits	14
SwissProt Accessions	Q99LJ0, Q6ZPR0, Q8BSV1	Gene names	Cttnbp2nl, Kiaa1433
Domain Architecture	No domain graphic available
Description	CTTNBP2 N-terminal-like protein.

DPPA3_MOUSE
θ value	3.0926 (rank : 27)	NC score	0.073132 (rank : 10)
Query Neighborhood Hits	50	Target Neighborhood Hits	6	Shared Neighborhood Hits	3
SwissProt Accessions	Q8QZY3	Gene names	Dppa3, Cap1p, Crg1, Pgc7
Domain Architecture	No domain graphic available
Description	Developmental pluripotency-associated protein 3 (Compaction-associated protein 1) (Primordial germ cell protein 7).

HTSF1_MOUSE
θ value	3.0926 (rank : 28)	NC score	0.055662 (rank : 14)
Query Neighborhood Hits	50	Target Neighborhood Hits	425	Shared Neighborhood Hits	21
SwissProt Accessions	Q8BGC0, Q1WWK0, Q9CT41, Q9DAU3	Gene names	Htatsf1
Domain Architecture	No domain graphic available
Description	HIV Tat-specific factor 1 homolog.

LEO1_HUMAN
θ value	3.0926 (rank : 29)	NC score	0.035854 (rank : 28)
Query Neighborhood Hits	50	Target Neighborhood Hits	958	Shared Neighborhood Hits	24
SwissProt Accessions	Q8WVC0, Q96N99	Gene names	LEO1, RDL
Domain Architecture	No domain graphic available
Description	RNA polymerase-associated protein LEO1 (Replicative senescence down- regulated leo1-like protein).

YTDC1_HUMAN
θ value	3.0926 (rank : 30)	NC score	0.057609 (rank : 13)
Query Neighborhood Hits	50	Target Neighborhood Hits	458	Shared Neighborhood Hits	21
SwissProt Accessions	Q96MU7, Q7Z622, Q8TF35	Gene names	YTHDC1, KIAA1966, YT521
Domain Architecture
Description	YTH domain-containing protein 1 (Putative splicing factor YT521).

AN30A_HUMAN
θ value	4.03905 (rank : 31)	NC score	0.027033 (rank : 34)
Query Neighborhood Hits	50	Target Neighborhood Hits	1119	Shared Neighborhood Hits	18
SwissProt Accessions	Q9BXX3, Q5W025	Gene names	ANKRD30A
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 30A (NY-BR-1 antigen).

IWS1_HUMAN
θ value	4.03905 (rank : 32)	NC score	0.040133 (rank : 25)
Query Neighborhood Hits	50	Target Neighborhood Hits	1241	Shared Neighborhood Hits	30
SwissProt Accessions	Q96ST2, Q6P157, Q8N3E8, Q96MI7, Q9NV97, Q9NWH8	Gene names	IWS1, IWS1L
Domain Architecture	No domain graphic available
Description	IWS1 homolog (IWS1-like protein).

MYST4_MOUSE
θ value	4.03905 (rank : 33)	NC score	0.030217 (rank : 33)
Query Neighborhood Hits	50	Target Neighborhood Hits	416	Shared Neighborhood Hits	18
SwissProt Accessions	Q8BRB7, Q7TNW5, Q8BG35, Q8C441, Q9JKX5	Gene names	Myst4
Domain Architecture	No domain graphic available
Description	Histone acetyltransferase MYST4 (EC 2.3.1.48) (EC 2.3.1.-) (MYST protein 4) (MOZ, YBF2/SAS3, SAS2 and TIP60 protein 4) (Querkopf protein).

RFC1_HUMAN
θ value	4.03905 (rank : 34)	NC score	0.040938 (rank : 22)
Query Neighborhood Hits	50	Target Neighborhood Hits	352	Shared Neighborhood Hits	16
SwissProt Accessions	P35251, Q5XKF5, Q6PKU0, Q86V41, Q86V46	Gene names	RFC1, RFC140
Domain Architecture
Description	Replication factor C subunit 1 (Replication factor C large subunit) (RF-C 140 kDa subunit) (Activator 1 140 kDa subunit) (Activator 1 large subunit) (A1 140 kDa subunit) (DNA-binding protein PO-GA).

SYCP1_HUMAN
θ value	4.03905 (rank : 35)	NC score	0.020395 (rank : 36)
Query Neighborhood Hits	50	Target Neighborhood Hits	1313	Shared Neighborhood Hits	19
SwissProt Accessions	Q15431, O14963	Gene names	SYCP1, SCP1
Domain Architecture
Description	Synaptonemal complex protein 1 (SCP-1).

SYNE2_HUMAN
θ value	4.03905 (rank : 36)	NC score	0.012889 (rank : 43)
Query Neighborhood Hits	50	Target Neighborhood Hits	1323	Shared Neighborhood Hits	16
SwissProt Accessions	Q8WXH0, Q8N1S3, Q8NF49, Q8TER7, Q8WWW3, Q8WWW4, Q8WWW5, Q8WXH1, Q9NU50, Q9UFQ4, Q9Y2L4, Q9Y4R1	Gene names	SYNE2, KIAA1011, NUA
Domain Architecture
Description	Nesprin-2 (Nuclear envelope spectrin repeat protein 2) (Syne-2) (Synaptic nuclear envelope protein 2) (Nucleus and actin connecting element protein) (Protein NUANCE).

CAN3_HUMAN
θ value	5.27518 (rank : 37)	NC score	0.009183 (rank : 48)
Query Neighborhood Hits	50	Target Neighborhood Hits	96	Shared Neighborhood Hits	4
SwissProt Accessions	P20807, Q9BTU4, Q9Y5S6, Q9Y5S7	Gene names	CAPN3, CANP3, CANPL3, NCL1
Domain Architecture
Description	Calpain-3 (EC 3.4.22.-) (Calpain L3) (Calpain p94) (Calcium-activated neutral proteinase 3) (CANP 3) (Muscle-specific calcium-activated neutral protease 3) (nCL-1).

F10A4_HUMAN
θ value	5.27518 (rank : 38)	NC score	0.032013 (rank : 32)
Query Neighborhood Hits	50	Target Neighborhood Hits	249	Shared Neighborhood Hits	11
SwissProt Accessions	Q8IZP2	Gene names	FAM10A4
Domain Architecture	No domain graphic available
Description	Protein FAM10A4.

RPGR_MOUSE
θ value	5.27518 (rank : 39)	NC score	0.032803 (rank : 30)
Query Neighborhood Hits	50	Target Neighborhood Hits	281	Shared Neighborhood Hits	14
SwissProt Accessions	Q9R0X5, O88408, Q9CU92	Gene names	Rpgr
Domain Architecture
Description	X-linked retinitis pigmentosa GTPase regulator (mRpgr).

SEC20_MOUSE
θ value	5.27518 (rank : 40)	NC score	0.019829 (rank : 37)
Query Neighborhood Hits	50	Target Neighborhood Hits	323	Shared Neighborhood Hits	4
SwissProt Accessions	Q6QD59, Q5M9M2	Gene names	Bnip1, Sec20, Sec20l
Domain Architecture	No domain graphic available
Description	Vesicle transport protein SEC20.

ANK1_HUMAN
θ value	6.88961 (rank : 41)	NC score	0.010572 (rank : 46)
Query Neighborhood Hits	50	Target Neighborhood Hits	416	Shared Neighborhood Hits	7
SwissProt Accessions	P16157, O43400, Q13768, Q59FP2, Q8N604, Q99407	Gene names	ANK1, ANK
Domain Architecture
Description	Ankyrin-1 (Erythrocyte ankyrin) (Ankyrin-R).

CO9_HUMAN
θ value	6.88961 (rank : 42)	NC score	0.012283 (rank : 44)
Query Neighborhood Hits	50	Target Neighborhood Hits	147	Shared Neighborhood Hits	2
SwissProt Accessions	P02748	Gene names	C9
Domain Architecture
Description	Complement component C9 precursor [Contains: Complement component C9a; Complement component C9b].

IWS1_MOUSE
θ value	6.88961 (rank : 43)	NC score	0.032719 (rank : 31)
Query Neighborhood Hits	50	Target Neighborhood Hits	1258	Shared Neighborhood Hits	25
SwissProt Accessions	Q8C1D8, Q3TQ25, Q3UWB0, Q6NVD1, Q8BY73, Q9D9H4	Gene names	Iws1, Iws1l
Domain Architecture	No domain graphic available
Description	IWS1 homolog (IWS1-like protein).

K1210_HUMAN
θ value	6.88961 (rank : 44)	NC score	0.042685 (rank : 20)
Query Neighborhood Hits	50	Target Neighborhood Hits	219	Shared Neighborhood Hits	8
SwissProt Accessions	Q9ULL0, Q5JPN4	Gene names	KIAA1210
Domain Architecture	No domain graphic available
Description	Protein KIAA1210.

MY18A_MOUSE
θ value	6.88961 (rank : 45)	NC score	0.009264 (rank : 47)
Query Neighborhood Hits	50	Target Neighborhood Hits	1989	Shared Neighborhood Hits	22
SwissProt Accessions	Q9JMH9, Q811D7	Gene names	Myo18a, Myspdz
Domain Architecture
Description	Myosin-18A (Myosin XVIIIa) (Myosin containing PDZ domain) (Molecule associated with JAK3 N-terminus) (MAJN).

PCGF6_MOUSE
θ value	6.88961 (rank : 46)	NC score	0.035942 (rank : 27)
Query Neighborhood Hits	50	Target Neighborhood Hits	163	Shared Neighborhood Hits	5
SwissProt Accessions	Q99NA9	Gene names	Pcgf6, Mblr, Rnf134
Domain Architecture	No domain graphic available
Description	Polycomb group RING finger protein 6 (RING finger protein 134) (Mel18 and Bmi1-like RING finger).

RPGR1_MOUSE
θ value	6.88961 (rank : 47)	NC score	0.045117 (rank : 18)
Query Neighborhood Hits	50	Target Neighborhood Hits	713	Shared Neighborhood Hits	27
SwissProt Accessions	Q9EPQ2, Q8CAC2, Q8CDJ9, Q91WE0, Q9CUK6, Q9D5Q1	Gene names	Rpgrip1
Domain Architecture	No domain graphic available
Description	X-linked retinitis pigmentosa GTPase regulator-interacting protein 1 (RPGR-interacting protein 1).

ABCA6_HUMAN
θ value	8.99809 (rank : 48)	NC score	0.005501 (rank : 50)
Query Neighborhood Hits	50	Target Neighborhood Hits	113	Shared Neighborhood Hits	4
SwissProt Accessions	Q8N139, Q6NSH9, Q8N856, Q8WWZ6	Gene names	ABCA6
Domain Architecture	No domain graphic available
Description	ATP-binding cassette sub-family A member 6.

NFM_HUMAN
θ value	8.99809 (rank : 49)	NC score	0.010916 (rank : 45)
Query Neighborhood Hits	50	Target Neighborhood Hits	1328	Shared Neighborhood Hits	25
SwissProt Accessions	P07197	Gene names	NEF3, NEFM, NFM
Domain Architecture
Description	Neurofilament triplet M protein (160 kDa neurofilament protein) (Neurofilament medium polypeptide) (NF-M) (Neurofilament 3).

SEC63_MOUSE
θ value	8.99809 (rank : 50)	NC score	0.021341 (rank : 35)
Query Neighborhood Hits	50	Target Neighborhood Hits	601	Shared Neighborhood Hits	19
SwissProt Accessions	Q8VHE0, Q8VEB9	Gene names	Sec63, Sec63l
Domain Architecture
Description	Translocation protein SEC63 homolog.

Hits sorted by NC score

IF2B_MOUSE
NC score	0.999962 (rank : 1)	θ value	1.32529e-160 (rank : 1)
Query Neighborhood Hits	50	Target Neighborhood Hits	50	Shared Neighborhood Hits	50
SwissProt Accessions	Q99L45, Q9CSH6, Q9CT12	Gene names	Eif2s2
Domain Architecture
Description	Eukaryotic translation initiation factor 2 subunit 2 (Eukaryotic translation initiation factor 2 subunit beta) (eIF-2-beta).

IF2B_HUMAN
NC score	0.980499 (rank : 2)	θ value	1.05009e-157 (rank : 2)
Query Neighborhood Hits	50	Target Neighborhood Hits	60	Shared Neighborhood Hits	29
SwissProt Accessions	P20042, Q9BVU0, Q9UJE4	Gene names	EIF2S2, EIF2B
Domain Architecture
Description	Eukaryotic translation initiation factor 2 subunit 2 (Eukaryotic translation initiation factor 2 subunit beta) (eIF-2-beta).

IF5_MOUSE
NC score	0.378830 (rank : 3)	θ value	7.59969e-07 (rank : 4)
Query Neighborhood Hits	50	Target Neighborhood Hits	35	Shared Neighborhood Hits	4
SwissProt Accessions	P59325	Gene names	Eif5
Domain Architecture
Description	Eukaryotic translation initiation factor 5 (eIF-5).

IF5_HUMAN
NC score	0.378140 (rank : 4)	θ value	7.59969e-07 (rank : 3)
Query Neighborhood Hits	50	Target Neighborhood Hits	36	Shared Neighborhood Hits	4
SwissProt Accessions	P55010, Q9H5N2, Q9UG48	Gene names	EIF5
Domain Architecture
Description	Eukaryotic translation initiation factor 5 (eIF-5).

FA21C_HUMAN
NC score	0.107120 (rank : 5)	θ value	0.62314 (rank : 14)
Query Neighborhood Hits	50	Target Neighborhood Hits	194	Shared Neighborhood Hits	15
SwissProt Accessions	Q9Y4E1, Q5SQU4, Q5SQU5, Q7L521, Q9UG79	Gene names	FAM21C, KIAA0592
Domain Architecture	No domain graphic available
Description	Protein FAM21C.

EDAR_MOUSE
NC score	0.088892 (rank : 6)	θ value	0.21417 (rank : 6)
Query Neighborhood Hits	50	Target Neighborhood Hits	66	Shared Neighborhood Hits	4
SwissProt Accessions	Q9R187, Q9DC43	Gene names	Edar, Dl
Domain Architecture
Description	Tumor necrosis factor receptor superfamily member EDAR precursor (Anhidrotic ectodysplasin receptor 1) (Ectodysplasin-A receptor) (Ectodermal dysplasia receptor) (Downless).

EDAR_HUMAN
NC score	0.084622 (rank : 7)	θ value	0.47712 (rank : 11)
Query Neighborhood Hits	50	Target Neighborhood Hits	84	Shared Neighborhood Hits	4
SwissProt Accessions	Q9UNE0, Q9UND9	Gene names	EDAR, DL
Domain Architecture
Description	Tumor necrosis factor receptor superfamily member EDAR precursor (Anhidrotic ectodysplasin receptor 1) (Ectodysplasin-A receptor) (EDA- A1 receptor) (Ectodermal dysplasia receptor) (Downless homolog).

PRPF3_MOUSE
NC score	0.079964 (rank : 8)	θ value	1.38821 (rank : 18)
Query Neighborhood Hits	50	Target Neighborhood Hits	74	Shared Neighborhood Hits	5
SwissProt Accessions	Q922U1, Q3TJH4, Q9D6C6	Gene names	Prpf3
Domain Architecture
Description	U4/U6 small nuclear ribonucleoprotein Prp3 (Pre-mRNA-splicing factor 3).

PRPF3_HUMAN
NC score	0.077393 (rank : 9)	θ value	1.81305 (rank : 21)
Query Neighborhood Hits	50	Target Neighborhood Hits	65	Shared Neighborhood Hits	5
SwissProt Accessions	O43395, O43446	Gene names	PRPF3, HPRP3, PRP3
Domain Architecture
Description	U4/U6 small nuclear ribonucleoprotein Prp3 (Pre-mRNA-splicing factor 3) (U4/U6 snRNP 90 kDa protein) (hPrp3).

DPPA3_MOUSE
NC score	0.073132 (rank : 10)	θ value	3.0926 (rank : 27)
Query Neighborhood Hits	50	Target Neighborhood Hits	6	Shared Neighborhood Hits	3
SwissProt Accessions	Q8QZY3	Gene names	Dppa3, Cap1p, Crg1, Pgc7
Domain Architecture	No domain graphic available
Description	Developmental pluripotency-associated protein 3 (Compaction-associated protein 1) (Primordial germ cell protein 7).

NAT10_HUMAN
NC score	0.071888 (rank : 11)	θ value	0.813845 (rank : 15)
Query Neighborhood Hits	50	Target Neighborhood Hits	62	Shared Neighborhood Hits	4
SwissProt Accessions	Q9H0A0, Q86WK5, Q9C0F4, Q9HA61, Q9NVF2	Gene names	NAT10, ALP, KIAA1709
Domain Architecture
Description	N-acetyltransferase 10 (EC 2.3.1.-).

AL2S4_MOUSE
NC score	0.068206 (rank : 12)	θ value	0.62314 (rank : 13)
Query Neighborhood Hits	50	Target Neighborhood Hits	193	Shared Neighborhood Hits	8
SwissProt Accessions	Q3V0J1, Q3TIS2	Gene names	Als2cr4
Domain Architecture	No domain graphic available
Description	Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 4 protein homolog.

YTDC1_HUMAN
NC score	0.057609 (rank : 13)	θ value	3.0926 (rank : 30)
Query Neighborhood Hits	50	Target Neighborhood Hits	458	Shared Neighborhood Hits	21
SwissProt Accessions	Q96MU7, Q7Z622, Q8TF35	Gene names	YTHDC1, KIAA1966, YT521
Domain Architecture
Description	YTH domain-containing protein 1 (Putative splicing factor YT521).

HTSF1_MOUSE
NC score	0.055662 (rank : 14)	θ value	3.0926 (rank : 28)
Query Neighborhood Hits	50	Target Neighborhood Hits	425	Shared Neighborhood Hits	21
SwissProt Accessions	Q8BGC0, Q1WWK0, Q9CT41, Q9DAU3	Gene names	Htatsf1
Domain Architecture	No domain graphic available
Description	HIV Tat-specific factor 1 homolog.

MAP1A_HUMAN
NC score	0.051546 (rank : 15)	θ value	0.21417 (rank : 7)
Query Neighborhood Hits	50	Target Neighborhood Hits	1626	Shared Neighborhood Hits	27
SwissProt Accessions	P78559, O95643, Q12973, Q15882, Q9UJT4	Gene names	MAP1A
Domain Architecture
Description	Microtubule-associated protein 1A (MAP 1A) (Proliferation-related protein p80) [Contains: MAP1 light chain LC2].

POT15_HUMAN
NC score	0.048401 (rank : 16)	θ value	0.0736092 (rank : 5)
Query Neighborhood Hits	50	Target Neighborhood Hits	893	Shared Neighborhood Hits	23
SwissProt Accessions	Q6S5H4, Q6NXN7, Q6S5H7	Gene names	POTE15
Domain Architecture	No domain graphic available
Description	Prostate, ovary, testis-expressed protein on chromosome 15.

RPGR_HUMAN
NC score	0.046165 (rank : 17)	θ value	1.06291 (rank : 17)
Query Neighborhood Hits	50	Target Neighborhood Hits	279	Shared Neighborhood Hits	14
SwissProt Accessions	Q92834, O00702, O00737, Q8N5T6, Q93039, Q9HD29, Q9UMR1	Gene names	RPGR, RP3, XLRP3
Domain Architecture
Description	X-linked retinitis pigmentosa GTPase regulator.

RPGR1_MOUSE
NC score	0.045117 (rank : 18)	θ value	6.88961 (rank : 47)
Query Neighborhood Hits	50	Target Neighborhood Hits	713	Shared Neighborhood Hits	27
SwissProt Accessions	Q9EPQ2, Q8CAC2, Q8CDJ9, Q91WE0, Q9CUK6, Q9D5Q1	Gene names	Rpgrip1
Domain Architecture	No domain graphic available
Description	X-linked retinitis pigmentosa GTPase regulator-interacting protein 1 (RPGR-interacting protein 1).

PCGF6_HUMAN
NC score	0.044261 (rank : 19)	θ value	2.36792 (rank : 23)
Query Neighborhood Hits	50	Target Neighborhood Hits	178	Shared Neighborhood Hits	5
SwissProt Accessions	Q9BYE7, Q5SYD1, Q5SYD6, Q96ID9, Q96SJ1	Gene names	PCGF6, MBLR, RNF134
Domain Architecture	No domain graphic available
Description	Polycomb group RING finger protein 6 (RING finger protein 134) (Mel18 and Bmi1-like RING finger).

K1210_HUMAN
NC score	0.042685 (rank : 20)	θ value	6.88961 (rank : 44)
Query Neighborhood Hits	50	Target Neighborhood Hits	219	Shared Neighborhood Hits	8
SwissProt Accessions	Q9ULL0, Q5JPN4	Gene names	KIAA1210
Domain Architecture	No domain graphic available
Description	Protein KIAA1210.

ANR21_HUMAN
NC score	0.042178 (rank : 21)	θ value	0.365318 (rank : 8)
Query Neighborhood Hits	50	Target Neighborhood Hits	864	Shared Neighborhood Hits	19
SwissProt Accessions	Q86YR6	Gene names	ANKRD21, POTE
Domain Architecture
Description	Ankyrin repeat domain-containing protein 21 (Protein POTE) (Prostate, ovary, testis-expressed protein).

RFC1_HUMAN
NC score	0.040938 (rank : 22)	θ value	4.03905 (rank : 34)
Query Neighborhood Hits	50	Target Neighborhood Hits	352	Shared Neighborhood Hits	16
SwissProt Accessions	P35251, Q5XKF5, Q6PKU0, Q86V41, Q86V46	Gene names	RFC1, RFC140
Domain Architecture
Description	Replication factor C subunit 1 (Replication factor C large subunit) (RF-C 140 kDa subunit) (Activator 1 140 kDa subunit) (Activator 1 large subunit) (A1 140 kDa subunit) (DNA-binding protein PO-GA).

TR150_MOUSE
NC score	0.040760 (rank : 23)	θ value	2.36792 (rank : 24)
Query Neighborhood Hits	50	Target Neighborhood Hits	468	Shared Neighborhood Hits	17
SwissProt Accessions	Q569Z6	Gene names	Thrap3, Trap150
Domain Architecture	No domain graphic available
Description	Thyroid hormone receptor-associated protein 3 (Thyroid hormone receptor-associated protein complex 150 kDa component) (Trap150).

AN32B_MOUSE
NC score	0.040445 (rank : 24)	θ value	3.0926 (rank : 25)
Query Neighborhood Hits	50	Target Neighborhood Hits	236	Shared Neighborhood Hits	12
SwissProt Accessions	Q9EST5	Gene names	Anp32b, Pal31
Domain Architecture	No domain graphic available
Description	Acidic leucine-rich nuclear phosphoprotein 32 family member B (Proliferation-related acidic leucine-rich protein PAL31).

IWS1_HUMAN
NC score	0.040133 (rank : 25)	θ value	4.03905 (rank : 32)
Query Neighborhood Hits	50	Target Neighborhood Hits	1241	Shared Neighborhood Hits	30
SwissProt Accessions	Q96ST2, Q6P157, Q8N3E8, Q96MI7, Q9NV97, Q9NWH8	Gene names	IWS1, IWS1L
Domain Architecture	No domain graphic available
Description	IWS1 homolog (IWS1-like protein).

CT2NL_HUMAN
NC score	0.038326 (rank : 26)	θ value	0.365318 (rank : 9)
Query Neighborhood Hits	50	Target Neighborhood Hits	1059	Shared Neighborhood Hits	17
SwissProt Accessions	Q9P2B4, Q96B40	Gene names	CTTNBP2NL, KIAA1433
Domain Architecture	No domain graphic available
Description	CTTNBP2 N-terminal-like protein.

PCGF6_MOUSE
NC score	0.035942 (rank : 27)	θ value	6.88961 (rank : 46)
Query Neighborhood Hits	50	Target Neighborhood Hits	163	Shared Neighborhood Hits	5
SwissProt Accessions	Q99NA9	Gene names	Pcgf6, Mblr, Rnf134
Domain Architecture	No domain graphic available
Description	Polycomb group RING finger protein 6 (RING finger protein 134) (Mel18 and Bmi1-like RING finger).

LEO1_HUMAN
NC score	0.035854 (rank : 28)	θ value	3.0926 (rank : 29)
Query Neighborhood Hits	50	Target Neighborhood Hits	958	Shared Neighborhood Hits	24
SwissProt Accessions	Q8WVC0, Q96N99	Gene names	LEO1, RDL
Domain Architecture	No domain graphic available
Description	RNA polymerase-associated protein LEO1 (Replicative senescence down- regulated leo1-like protein).

CT2NL_MOUSE
NC score	0.033177 (rank : 29)	θ value	3.0926 (rank : 26)
Query Neighborhood Hits	50	Target Neighborhood Hits	902	Shared Neighborhood Hits	14
SwissProt Accessions	Q99LJ0, Q6ZPR0, Q8BSV1	Gene names	Cttnbp2nl, Kiaa1433
Domain Architecture	No domain graphic available
Description	CTTNBP2 N-terminal-like protein.

RPGR_MOUSE
NC score	0.032803 (rank : 30)	θ value	5.27518 (rank : 39)
Query Neighborhood Hits	50	Target Neighborhood Hits	281	Shared Neighborhood Hits	14
SwissProt Accessions	Q9R0X5, O88408, Q9CU92	Gene names	Rpgr
Domain Architecture
Description	X-linked retinitis pigmentosa GTPase regulator (mRpgr).

IWS1_MOUSE
NC score	0.032719 (rank : 31)	θ value	6.88961 (rank : 43)
Query Neighborhood Hits	50	Target Neighborhood Hits	1258	Shared Neighborhood Hits	25
SwissProt Accessions	Q8C1D8, Q3TQ25, Q3UWB0, Q6NVD1, Q8BY73, Q9D9H4	Gene names	Iws1, Iws1l
Domain Architecture	No domain graphic available
Description	IWS1 homolog (IWS1-like protein).

F10A4_HUMAN
NC score	0.032013 (rank : 32)	θ value	5.27518 (rank : 38)
Query Neighborhood Hits	50	Target Neighborhood Hits	249	Shared Neighborhood Hits	11
SwissProt Accessions	Q8IZP2	Gene names	FAM10A4
Domain Architecture	No domain graphic available
Description	Protein FAM10A4.

MYST4_MOUSE
NC score	0.030217 (rank : 33)	θ value	4.03905 (rank : 33)
Query Neighborhood Hits	50	Target Neighborhood Hits	416	Shared Neighborhood Hits	18
SwissProt Accessions	Q8BRB7, Q7TNW5, Q8BG35, Q8C441, Q9JKX5	Gene names	Myst4
Domain Architecture	No domain graphic available
Description	Histone acetyltransferase MYST4 (EC 2.3.1.48) (EC 2.3.1.-) (MYST protein 4) (MOZ, YBF2/SAS3, SAS2 and TIP60 protein 4) (Querkopf protein).

AN30A_HUMAN
NC score	0.027033 (rank : 34)	θ value	4.03905 (rank : 31)
Query Neighborhood Hits	50	Target Neighborhood Hits	1119	Shared Neighborhood Hits	18
SwissProt Accessions	Q9BXX3, Q5W025	Gene names	ANKRD30A
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 30A (NY-BR-1 antigen).

SEC63_MOUSE
NC score	0.021341 (rank : 35)	θ value	8.99809 (rank : 50)
Query Neighborhood Hits	50	Target Neighborhood Hits	601	Shared Neighborhood Hits	19
SwissProt Accessions	Q8VHE0, Q8VEB9	Gene names	Sec63, Sec63l
Domain Architecture
Description	Translocation protein SEC63 homolog.

SYCP1_HUMAN
NC score	0.020395 (rank : 36)	θ value	4.03905 (rank : 35)
Query Neighborhood Hits	50	Target Neighborhood Hits	1313	Shared Neighborhood Hits	19
SwissProt Accessions	Q15431, O14963	Gene names	SYCP1, SCP1
Domain Architecture
Description	Synaptonemal complex protein 1 (SCP-1).

SEC20_MOUSE
NC score	0.019829 (rank : 37)	θ value	5.27518 (rank : 40)
Query Neighborhood Hits	50	Target Neighborhood Hits	323	Shared Neighborhood Hits	4
SwissProt Accessions	Q6QD59, Q5M9M2	Gene names	Bnip1, Sec20, Sec20l
Domain Architecture	No domain graphic available
Description	Vesicle transport protein SEC20.

ETV3_HUMAN
NC score	0.018838 (rank : 38)	θ value	1.81305 (rank : 20)
Query Neighborhood Hits	50	Target Neighborhood Hits	312	Shared Neighborhood Hits	4
SwissProt Accessions	P41162, Q8TAC8, Q9BX30	Gene names	ETV3, METS, PE1
Domain Architecture	No domain graphic available
Description	ETS translocation variant 3 (ETS-domain transcriptional repressor PE1) (PE-1) (Mitogenic Ets transcriptional suppressor).

GLI3_MOUSE
NC score	0.017347 (rank : 39)	θ value	0.365318 (rank : 10)
Query Neighborhood Hits	50	Target Neighborhood Hits	807	Shared Neighborhood Hits	5
SwissProt Accessions	Q61602	Gene names	Gli3
Domain Architecture	No domain graphic available
Description	Zinc finger protein GLI3.

GLI3_HUMAN
NC score	0.017142 (rank : 40)	θ value	0.47712 (rank : 12)
Query Neighborhood Hits	50	Target Neighborhood Hits	871	Shared Neighborhood Hits	8
SwissProt Accessions	P10071, O75219, Q9UDT5, Q9UJ39	Gene names	GLI3
Domain Architecture	No domain graphic available
Description	Zinc finger protein GLI3.

SMCA2_HUMAN
NC score	0.016694 (rank : 41)	θ value	1.38821 (rank : 19)
Query Neighborhood Hits	50	Target Neighborhood Hits	503	Shared Neighborhood Hits	12
SwissProt Accessions	P51531	Gene names	SMARCA2, BRM, SNF2A, SNF2L2
Domain Architecture
Description	Probable global transcription activator SNF2L2 (EC 3.6.1.-) (ATP- dependent helicase SMARCA2) (SNF2-alpha) (SWI/SNF-related matrix- associated actin-dependent regulator of chromatin subfamily A member 2) (hBRM).

TCF8_HUMAN
NC score	0.013724 (rank : 42)	θ value	0.813845 (rank : 16)
Query Neighborhood Hits	50	Target Neighborhood Hits	1057	Shared Neighborhood Hits	23
SwissProt Accessions	P37275, Q12924, Q13800	Gene names	TCF8, AREB6
Domain Architecture
Description	Transcription factor 8 (NIL-2-A zinc finger protein) (Negative regulator of IL2).

SYNE2_HUMAN
NC score	0.012889 (rank : 43)	θ value	4.03905 (rank : 36)
Query Neighborhood Hits	50	Target Neighborhood Hits	1323	Shared Neighborhood Hits	16
SwissProt Accessions	Q8WXH0, Q8N1S3, Q8NF49, Q8TER7, Q8WWW3, Q8WWW4, Q8WWW5, Q8WXH1, Q9NU50, Q9UFQ4, Q9Y2L4, Q9Y4R1	Gene names	SYNE2, KIAA1011, NUA
Domain Architecture
Description	Nesprin-2 (Nuclear envelope spectrin repeat protein 2) (Syne-2) (Synaptic nuclear envelope protein 2) (Nucleus and actin connecting element protein) (Protein NUANCE).

CO9_HUMAN
NC score	0.012283 (rank : 44)	θ value	6.88961 (rank : 42)
Query Neighborhood Hits	50	Target Neighborhood Hits	147	Shared Neighborhood Hits	2
SwissProt Accessions	P02748	Gene names	C9
Domain Architecture
Description	Complement component C9 precursor [Contains: Complement component C9a; Complement component C9b].

NFM_HUMAN
NC score	0.010916 (rank : 45)	θ value	8.99809 (rank : 49)
Query Neighborhood Hits	50	Target Neighborhood Hits	1328	Shared Neighborhood Hits	25
SwissProt Accessions	P07197	Gene names	NEF3, NEFM, NFM
Domain Architecture
Description	Neurofilament triplet M protein (160 kDa neurofilament protein) (Neurofilament medium polypeptide) (NF-M) (Neurofilament 3).

ANK1_HUMAN
NC score	0.010572 (rank : 46)	θ value	6.88961 (rank : 41)
Query Neighborhood Hits	50	Target Neighborhood Hits	416	Shared Neighborhood Hits	7
SwissProt Accessions	P16157, O43400, Q13768, Q59FP2, Q8N604, Q99407	Gene names	ANK1, ANK
Domain Architecture
Description	Ankyrin-1 (Erythrocyte ankyrin) (Ankyrin-R).

MY18A_MOUSE
NC score	0.009264 (rank : 47)	θ value	6.88961 (rank : 45)
Query Neighborhood Hits	50	Target Neighborhood Hits	1989	Shared Neighborhood Hits	22
SwissProt Accessions	Q9JMH9, Q811D7	Gene names	Myo18a, Myspdz
Domain Architecture
Description	Myosin-18A (Myosin XVIIIa) (Myosin containing PDZ domain) (Molecule associated with JAK3 N-terminus) (MAJN).

CAN3_HUMAN
NC score	0.009183 (rank : 48)	θ value	5.27518 (rank : 37)
Query Neighborhood Hits	50	Target Neighborhood Hits	96	Shared Neighborhood Hits	4
SwissProt Accessions	P20807, Q9BTU4, Q9Y5S6, Q9Y5S7	Gene names	CAPN3, CANP3, CANPL3, NCL1
Domain Architecture
Description	Calpain-3 (EC 3.4.22.-) (Calpain L3) (Calpain p94) (Calcium-activated neutral proteinase 3) (CANP 3) (Muscle-specific calcium-activated neutral protease 3) (nCL-1).

GAK_MOUSE
NC score	0.005908 (rank : 49)	θ value	2.36792 (rank : 22)
Query Neighborhood Hits	50	Target Neighborhood Hits	964	Shared Neighborhood Hits	3
SwissProt Accessions	Q99KY4, Q6P1I8, Q6P9S5, Q8BM74, Q8K0Q4	Gene names	Gak
Domain Architecture	No domain graphic available
Description	Cyclin G-associated kinase (EC 2.7.11.1).

ABCA6_HUMAN
NC score	0.005501 (rank : 50)	θ value	8.99809 (rank : 48)
Query Neighborhood Hits	50	Target Neighborhood Hits	113	Shared Neighborhood Hits	4
SwissProt Accessions	Q8N139, Q6NSH9, Q8N856, Q8WWZ6	Gene names	ABCA6
Domain Architecture	No domain graphic available
Description	ATP-binding cassette sub-family A member 6.