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Network neighborhood for query Sequence : EAA5_HUMAN

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EAA5_HUMAN
SwissProt Accessions	O00341	Gene names	SLC1A7, EAAT5
Domain Architecture
Description	Excitatory amino acid transporter 5 (Retinal glutamate transporter).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

EAA5_HUMAN
θ value	0 (rank : 1)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	20	Target Neighborhood Hits	20	Shared Neighborhood Hits	20
SwissProt Accessions	O00341	Gene names	SLC1A7, EAAT5
Domain Architecture
Description	Excitatory amino acid transporter 5 (Retinal glutamate transporter).

EAA4_HUMAN
θ value	7.09276e-130 (rank : 2)	NC score	0.991669 (rank : 2)
Query Neighborhood Hits	20	Target Neighborhood Hits	17	Shared Neighborhood Hits	13
SwissProt Accessions	P48664	Gene names	SLC1A6, EAAT4
Domain Architecture
Description	Excitatory amino acid transporter 4 (Sodium-dependent glutamate/aspartate transporter).

EAA4_MOUSE
θ value	3.5201e-129 (rank : 3)	NC score	0.991527 (rank : 3)
Query Neighborhood Hits	20	Target Neighborhood Hits	21	Shared Neighborhood Hits	13
SwissProt Accessions	O35544	Gene names	Slc1a6, Eaat4
Domain Architecture
Description	Excitatory amino acid transporter 4 (Sodium-dependent glutamate/aspartate transporter) (High-affinity neuronal glutamate transporter).

EAA1_HUMAN
θ value	4.16784e-122 (rank : 4)	NC score	0.990682 (rank : 4)
Query Neighborhood Hits	20	Target Neighborhood Hits	15	Shared Neighborhood Hits	13
SwissProt Accessions	P43003	Gene names	SLC1A3, EAAT1, GLAST1
Domain Architecture
Description	Excitatory amino acid transporter 1 (Sodium-dependent glutamate/aspartate transporter 1) (Glial glutamate transporter) (GLAST-1).

EAA1_MOUSE
θ value	4.60808e-121 (rank : 5)	NC score	0.990499 (rank : 5)
Query Neighborhood Hits	20	Target Neighborhood Hits	16	Shared Neighborhood Hits	13
SwissProt Accessions	P56564, Q99P53	Gene names	Slc1a3, Eaat1, Gmt1
Domain Architecture
Description	Excitatory amino acid transporter 1 (Sodium-dependent glutamate/aspartate transporter) (High-affinity neuronal glutamate transporter) (Glial high affinity glutamate transporter) (GLAST).

EAA3_HUMAN
θ value	2.6227e-108 (rank : 6)	NC score	0.988056 (rank : 7)
Query Neighborhood Hits	20	Target Neighborhood Hits	25	Shared Neighborhood Hits	13
SwissProt Accessions	P43005, O75587, Q5VZ24, Q8N199, Q9UEW2	Gene names	SLC1A1, EAAC1, EAAT3
Domain Architecture
Description	Excitatory amino acid transporter 3 (Sodium-dependent glutamate/aspartate transporter 3) (Excitatory amino-acid carrier 1) (Neuronal and epithelial glutamate transporter).

EAA3_MOUSE
θ value	7.63087e-108 (rank : 7)	NC score	0.988202 (rank : 6)
Query Neighborhood Hits	20	Target Neighborhood Hits	20	Shared Neighborhood Hits	13
SwissProt Accessions	P51906, O35869, O35875	Gene names	Slc1a1, Eaac1, Eaat3
Domain Architecture
Description	Excitatory amino acid transporter 3 (Sodium-dependent glutamate/aspartate transporter 3) (Excitatory amino-acid carrier 1).

EAA2_HUMAN
θ value	5.46864e-106 (rank : 8)	NC score	0.986117 (rank : 9)
Query Neighborhood Hits	20	Target Neighborhood Hits	14	Shared Neighborhood Hits	13
SwissProt Accessions	P43004, Q14417	Gene names	SLC1A2, EAAT2, GLT1
Domain Architecture
Description	Excitatory amino acid transporter 2 (Sodium-dependent glutamate/aspartate transporter 2).

EAA2_MOUSE
θ value	2.07809e-105 (rank : 9)	NC score	0.986154 (rank : 8)
Query Neighborhood Hits	20	Target Neighborhood Hits	13	Shared Neighborhood Hits	13
SwissProt Accessions	P43006, O35877, O54686, O54687	Gene names	Slc1a2, Eaat2, Glt1
Domain Architecture
Description	Excitatory amino acid transporter 2 (Sodium-dependent glutamate/aspartate transporter 2) (GLT-1).

SATT_HUMAN
θ value	8.77142e-88 (rank : 10)	NC score	0.982651 (rank : 10)
Query Neighborhood Hits	20	Target Neighborhood Hits	17	Shared Neighborhood Hits	13
SwissProt Accessions	P43007	Gene names	SLC1A4, ASCT1, SATT
Domain Architecture
Description	Neutral amino acid transporter A (SATT) (Alanine/serine/cysteine/ threonine transporter) (ASCT1).

SATT_MOUSE
θ value	2.82168e-86 (rank : 11)	NC score	0.982511 (rank : 11)
Query Neighborhood Hits	20	Target Neighborhood Hits	14	Shared Neighborhood Hits	13
SwissProt Accessions	O35874	Gene names	Slc1a4, Asct1
Domain Architecture
Description	Neutral amino acid transporter A (SATT) (Alanine/serine/cysteine/ threonine transporter) (ASCT1).

AAAT_HUMAN
θ value	3.56943e-81 (rank : 12)	NC score	0.979625 (rank : 12)
Query Neighborhood Hits	20	Target Neighborhood Hits	15	Shared Neighborhood Hits	13
SwissProt Accessions	Q15758, O95720, Q96RL9, Q9BWQ3, Q9UNP2	Gene names	SLC1A5, ASCT2, M7V1, RDR, RDRC
Domain Architecture
Description	Neutral amino acid transporter B(0) (ATB(0)) (Sodium-dependent neutral amino acid transporter type 2) (RD114/simian type D retrovirus receptor) (Baboon M7 virus receptor).

AAAT_MOUSE
θ value	2.31364e-80 (rank : 13)	NC score	0.978207 (rank : 13)
Query Neighborhood Hits	20	Target Neighborhood Hits	17	Shared Neighborhood Hits	13
SwissProt Accessions	P51912, Q61326	Gene names	Slc1a5, Aaat, Asct2, Slc1a7
Domain Architecture
Description	Neutral amino acid transporter B (Insulin-activated amino acid transporter) (ASC-like Na(+)-dependent neutral amino acid transporter ASCT2).

GTR3_MOUSE
θ value	1.38821 (rank : 14)	NC score	0.008541 (rank : 16)
Query Neighborhood Hits	20	Target Neighborhood Hits	45	Shared Neighborhood Hits	2
SwissProt Accessions	P32037	Gene names	Slc2a3, Glut-3, Glut3
Domain Architecture
Description	Solute carrier family 2, facilitated glucose transporter member 3 (Glucose transporter type 3, brain).

ARAF_HUMAN
θ value	3.0926 (rank : 15)	NC score	0.000278 (rank : 20)
Query Neighborhood Hits	20	Target Neighborhood Hits	924	Shared Neighborhood Hits	3
SwissProt Accessions	P10398, P07557, Q5H9B3	Gene names	ARAF, ARAF1, PKS, PKS2
Domain Architecture
Description	A-Raf proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1) (A- raf-1) (Proto-oncogene Pks).

ARAF_MOUSE
θ value	3.0926 (rank : 16)	NC score	0.000301 (rank : 19)
Query Neighborhood Hits	20	Target Neighborhood Hits	874	Shared Neighborhood Hits	3
SwissProt Accessions	P04627, Q99J44, Q9CTT5, Q9D6R6, Q9DBU7	Gene names	Araf, A-raf, Araf1
Domain Architecture
Description	A-Raf proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1).

I28RA_HUMAN
θ value	3.0926 (rank : 17)	NC score	0.015738 (rank : 14)
Query Neighborhood Hits	20	Target Neighborhood Hits	32	Shared Neighborhood Hits	2
SwissProt Accessions	Q8IU57, Q6ZML8, Q8IZI7, Q8IZI8	Gene names	IL28RA, IFNLR1, LICR2
Domain Architecture	No domain graphic available
Description	Interleukin-28 receptor alpha chain precursor (IL-28R-alpha) (IL-28RA) (Cytokine receptor family 2 member 12) (Cytokine receptor class-II member 12) (CRF2-12) (Interferon lambda receptor 1) (IFN-lambda R1) (Likely interleukin or cytokine receptor 2).

B4GN3_MOUSE
θ value	4.03905 (rank : 18)	NC score	0.009571 (rank : 15)
Query Neighborhood Hits	20	Target Neighborhood Hits	49	Shared Neighborhood Hits	2
SwissProt Accessions	Q6L8S8	Gene names	B4galnt3
Domain Architecture	No domain graphic available
Description	N-acetyl-beta-glucosaminyl-glycoprotein 4-beta-N- acetylgalactosaminyltransferase 2 (EC 2.4.1.244) (NGalNAc-T2) (Beta- 1,4-N-acetylgalactosaminyltransferase III) (Beta4GalNAc-T3) (Beta4GalNAcT3).

TPA_HUMAN
θ value	5.27518 (rank : 19)	NC score	0.000923 (rank : 18)
Query Neighborhood Hits	20	Target Neighborhood Hits	324	Shared Neighborhood Hits	2
SwissProt Accessions	P00750, Q15103, Q7Z7N2, Q86YK8, Q9BU99	Gene names	PLAT
Domain Architecture
Description	Tissue-type plasminogen activator precursor (EC 3.4.21.68) (tPA) (t- PA) (t-plasminogen activator) (Alteplase) (Reteplase) [Contains: Tissue-type plasminogen activator chain A; Tissue-type plasminogen activator chain B].

HSH2D_HUMAN
θ value	6.88961 (rank : 20)	NC score	0.007045 (rank : 17)
Query Neighborhood Hits	20	Target Neighborhood Hits	159	Shared Neighborhood Hits	2
SwissProt Accessions	Q96JZ2, Q6ZNG7	Gene names	HSH2D, ALX
Domain Architecture	No domain graphic available
Description	Hematopoietic SH2 domain-containing protein (Hematopoietic SH2 protein) (Adaptor in lymphocytes of unknown function X).

Hits sorted by NC score

EAA5_HUMAN
NC score	0.999962 (rank : 1)	θ value	0 (rank : 1)
Query Neighborhood Hits	20	Target Neighborhood Hits	20	Shared Neighborhood Hits	20
SwissProt Accessions	O00341	Gene names	SLC1A7, EAAT5
Domain Architecture
Description	Excitatory amino acid transporter 5 (Retinal glutamate transporter).

EAA4_HUMAN
NC score	0.991669 (rank : 2)	θ value	7.09276e-130 (rank : 2)
Query Neighborhood Hits	20	Target Neighborhood Hits	17	Shared Neighborhood Hits	13
SwissProt Accessions	P48664	Gene names	SLC1A6, EAAT4
Domain Architecture
Description	Excitatory amino acid transporter 4 (Sodium-dependent glutamate/aspartate transporter).

EAA4_MOUSE
NC score	0.991527 (rank : 3)	θ value	3.5201e-129 (rank : 3)
Query Neighborhood Hits	20	Target Neighborhood Hits	21	Shared Neighborhood Hits	13
SwissProt Accessions	O35544	Gene names	Slc1a6, Eaat4
Domain Architecture
Description	Excitatory amino acid transporter 4 (Sodium-dependent glutamate/aspartate transporter) (High-affinity neuronal glutamate transporter).

EAA1_HUMAN
NC score	0.990682 (rank : 4)	θ value	4.16784e-122 (rank : 4)
Query Neighborhood Hits	20	Target Neighborhood Hits	15	Shared Neighborhood Hits	13
SwissProt Accessions	P43003	Gene names	SLC1A3, EAAT1, GLAST1
Domain Architecture
Description	Excitatory amino acid transporter 1 (Sodium-dependent glutamate/aspartate transporter 1) (Glial glutamate transporter) (GLAST-1).

EAA1_MOUSE
NC score	0.990499 (rank : 5)	θ value	4.60808e-121 (rank : 5)
Query Neighborhood Hits	20	Target Neighborhood Hits	16	Shared Neighborhood Hits	13
SwissProt Accessions	P56564, Q99P53	Gene names	Slc1a3, Eaat1, Gmt1
Domain Architecture
Description	Excitatory amino acid transporter 1 (Sodium-dependent glutamate/aspartate transporter) (High-affinity neuronal glutamate transporter) (Glial high affinity glutamate transporter) (GLAST).

EAA3_MOUSE
NC score	0.988202 (rank : 6)	θ value	7.63087e-108 (rank : 7)
Query Neighborhood Hits	20	Target Neighborhood Hits	20	Shared Neighborhood Hits	13
SwissProt Accessions	P51906, O35869, O35875	Gene names	Slc1a1, Eaac1, Eaat3
Domain Architecture
Description	Excitatory amino acid transporter 3 (Sodium-dependent glutamate/aspartate transporter 3) (Excitatory amino-acid carrier 1).

EAA3_HUMAN
NC score	0.988056 (rank : 7)	θ value	2.6227e-108 (rank : 6)
Query Neighborhood Hits	20	Target Neighborhood Hits	25	Shared Neighborhood Hits	13
SwissProt Accessions	P43005, O75587, Q5VZ24, Q8N199, Q9UEW2	Gene names	SLC1A1, EAAC1, EAAT3
Domain Architecture
Description	Excitatory amino acid transporter 3 (Sodium-dependent glutamate/aspartate transporter 3) (Excitatory amino-acid carrier 1) (Neuronal and epithelial glutamate transporter).

EAA2_MOUSE
NC score	0.986154 (rank : 8)	θ value	2.07809e-105 (rank : 9)
Query Neighborhood Hits	20	Target Neighborhood Hits	13	Shared Neighborhood Hits	13
SwissProt Accessions	P43006, O35877, O54686, O54687	Gene names	Slc1a2, Eaat2, Glt1
Domain Architecture
Description	Excitatory amino acid transporter 2 (Sodium-dependent glutamate/aspartate transporter 2) (GLT-1).

EAA2_HUMAN
NC score	0.986117 (rank : 9)	θ value	5.46864e-106 (rank : 8)
Query Neighborhood Hits	20	Target Neighborhood Hits	14	Shared Neighborhood Hits	13
SwissProt Accessions	P43004, Q14417	Gene names	SLC1A2, EAAT2, GLT1
Domain Architecture
Description	Excitatory amino acid transporter 2 (Sodium-dependent glutamate/aspartate transporter 2).

SATT_HUMAN
NC score	0.982651 (rank : 10)	θ value	8.77142e-88 (rank : 10)
Query Neighborhood Hits	20	Target Neighborhood Hits	17	Shared Neighborhood Hits	13
SwissProt Accessions	P43007	Gene names	SLC1A4, ASCT1, SATT
Domain Architecture
Description	Neutral amino acid transporter A (SATT) (Alanine/serine/cysteine/ threonine transporter) (ASCT1).

SATT_MOUSE
NC score	0.982511 (rank : 11)	θ value	2.82168e-86 (rank : 11)
Query Neighborhood Hits	20	Target Neighborhood Hits	14	Shared Neighborhood Hits	13
SwissProt Accessions	O35874	Gene names	Slc1a4, Asct1
Domain Architecture
Description	Neutral amino acid transporter A (SATT) (Alanine/serine/cysteine/ threonine transporter) (ASCT1).

AAAT_HUMAN
NC score	0.979625 (rank : 12)	θ value	3.56943e-81 (rank : 12)
Query Neighborhood Hits	20	Target Neighborhood Hits	15	Shared Neighborhood Hits	13
SwissProt Accessions	Q15758, O95720, Q96RL9, Q9BWQ3, Q9UNP2	Gene names	SLC1A5, ASCT2, M7V1, RDR, RDRC
Domain Architecture
Description	Neutral amino acid transporter B(0) (ATB(0)) (Sodium-dependent neutral amino acid transporter type 2) (RD114/simian type D retrovirus receptor) (Baboon M7 virus receptor).

AAAT_MOUSE
NC score	0.978207 (rank : 13)	θ value	2.31364e-80 (rank : 13)
Query Neighborhood Hits	20	Target Neighborhood Hits	17	Shared Neighborhood Hits	13
SwissProt Accessions	P51912, Q61326	Gene names	Slc1a5, Aaat, Asct2, Slc1a7
Domain Architecture
Description	Neutral amino acid transporter B (Insulin-activated amino acid transporter) (ASC-like Na(+)-dependent neutral amino acid transporter ASCT2).

I28RA_HUMAN
NC score	0.015738 (rank : 14)	θ value	3.0926 (rank : 17)
Query Neighborhood Hits	20	Target Neighborhood Hits	32	Shared Neighborhood Hits	2
SwissProt Accessions	Q8IU57, Q6ZML8, Q8IZI7, Q8IZI8	Gene names	IL28RA, IFNLR1, LICR2
Domain Architecture	No domain graphic available
Description	Interleukin-28 receptor alpha chain precursor (IL-28R-alpha) (IL-28RA) (Cytokine receptor family 2 member 12) (Cytokine receptor class-II member 12) (CRF2-12) (Interferon lambda receptor 1) (IFN-lambda R1) (Likely interleukin or cytokine receptor 2).

B4GN3_MOUSE
NC score	0.009571 (rank : 15)	θ value	4.03905 (rank : 18)
Query Neighborhood Hits	20	Target Neighborhood Hits	49	Shared Neighborhood Hits	2
SwissProt Accessions	Q6L8S8	Gene names	B4galnt3
Domain Architecture	No domain graphic available
Description	N-acetyl-beta-glucosaminyl-glycoprotein 4-beta-N- acetylgalactosaminyltransferase 2 (EC 2.4.1.244) (NGalNAc-T2) (Beta- 1,4-N-acetylgalactosaminyltransferase III) (Beta4GalNAc-T3) (Beta4GalNAcT3).

GTR3_MOUSE
NC score	0.008541 (rank : 16)	θ value	1.38821 (rank : 14)
Query Neighborhood Hits	20	Target Neighborhood Hits	45	Shared Neighborhood Hits	2
SwissProt Accessions	P32037	Gene names	Slc2a3, Glut-3, Glut3
Domain Architecture
Description	Solute carrier family 2, facilitated glucose transporter member 3 (Glucose transporter type 3, brain).

HSH2D_HUMAN
NC score	0.007045 (rank : 17)	θ value	6.88961 (rank : 20)
Query Neighborhood Hits	20	Target Neighborhood Hits	159	Shared Neighborhood Hits	2
SwissProt Accessions	Q96JZ2, Q6ZNG7	Gene names	HSH2D, ALX
Domain Architecture	No domain graphic available
Description	Hematopoietic SH2 domain-containing protein (Hematopoietic SH2 protein) (Adaptor in lymphocytes of unknown function X).

TPA_HUMAN
NC score	0.000923 (rank : 18)	θ value	5.27518 (rank : 19)
Query Neighborhood Hits	20	Target Neighborhood Hits	324	Shared Neighborhood Hits	2
SwissProt Accessions	P00750, Q15103, Q7Z7N2, Q86YK8, Q9BU99	Gene names	PLAT
Domain Architecture
Description	Tissue-type plasminogen activator precursor (EC 3.4.21.68) (tPA) (t- PA) (t-plasminogen activator) (Alteplase) (Reteplase) [Contains: Tissue-type plasminogen activator chain A; Tissue-type plasminogen activator chain B].

ARAF_MOUSE
NC score	0.000301 (rank : 19)	θ value	3.0926 (rank : 16)
Query Neighborhood Hits	20	Target Neighborhood Hits	874	Shared Neighborhood Hits	3
SwissProt Accessions	P04627, Q99J44, Q9CTT5, Q9D6R6, Q9DBU7	Gene names	Araf, A-raf, Araf1
Domain Architecture
Description	A-Raf proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1).

ARAF_HUMAN
NC score	0.000278 (rank : 20)	θ value	3.0926 (rank : 15)
Query Neighborhood Hits	20	Target Neighborhood Hits	924	Shared Neighborhood Hits	3
SwissProt Accessions	P10398, P07557, Q5H9B3	Gene names	ARAF, ARAF1, PKS, PKS2
Domain Architecture
Description	A-Raf proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1) (A- raf-1) (Proto-oncogene Pks).