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Network neighborhood for query Sequence : DNL4_HUMAN

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DNL4_HUMAN
SwissProt Accessions	P49917, Q8IY66, Q8TEU5	Gene names	LIG4
Domain Architecture
Description	DNA ligase 4 (EC 6.5.1.1) (DNA ligase IV) (Polydeoxyribonucleotide synthase [ATP] 4).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

DNL4_HUMAN
θ value	0 (rank : 1)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	14	Target Neighborhood Hits	14	Shared Neighborhood Hits	14
SwissProt Accessions	P49917, Q8IY66, Q8TEU5	Gene names	LIG4
Domain Architecture
Description	DNA ligase 4 (EC 6.5.1.1) (DNA ligase IV) (Polydeoxyribonucleotide synthase [ATP] 4).

DNL4_MOUSE
θ value	0 (rank : 2)	NC score	0.998148 (rank : 2)
Query Neighborhood Hits	14	Target Neighborhood Hits	17	Shared Neighborhood Hits	9
SwissProt Accessions	Q8BTF7, Q3UG76	Gene names	Lig4
Domain Architecture	No domain graphic available
Description	DNA ligase 4 (EC 6.5.1.1) (DNA ligase IV) (Polydeoxyribonucleotide synthase [ATP] 4).

DNL3_HUMAN
θ value	7.04741e-37 (rank : 3)	NC score	0.724692 (rank : 3)
Query Neighborhood Hits	14	Target Neighborhood Hits	49	Shared Neighborhood Hits	6
SwissProt Accessions	P49916, Q16714	Gene names	LIG3
Domain Architecture
Description	DNA ligase 3 (EC 6.5.1.1) (DNA ligase III) (Polydeoxyribonucleotide synthase [ATP] 3).

DNL3_MOUSE
θ value	6.59618e-35 (rank : 4)	NC score	0.715810 (rank : 4)
Query Neighborhood Hits	14	Target Neighborhood Hits	37	Shared Neighborhood Hits	6
SwissProt Accessions	P97386, P97385	Gene names	Lig3
Domain Architecture
Description	DNA ligase 3 (EC 6.5.1.1) (DNA ligase III) (Polydeoxyribonucleotide synthase [ATP] 3).

DNL1_MOUSE
θ value	3.17079e-29 (rank : 5)	NC score	0.679907 (rank : 5)
Query Neighborhood Hits	14	Target Neighborhood Hits	110	Shared Neighborhood Hits	6
SwissProt Accessions	P37913	Gene names	Lig1, Lig-1
Domain Architecture
Description	DNA ligase 1 (EC 6.5.1.1) (DNA ligase I) (Polydeoxyribonucleotide synthase [ATP] 1).

DNL1_HUMAN
θ value	3.50572e-28 (rank : 6)	NC score	0.652142 (rank : 6)
Query Neighborhood Hits	14	Target Neighborhood Hits	216	Shared Neighborhood Hits	6
SwissProt Accessions	P18858	Gene names	LIG1
Domain Architecture
Description	DNA ligase 1 (EC 6.5.1.1) (DNA ligase I) (Polydeoxyribonucleotide synthase [ATP] 1).

DFFA_MOUSE
θ value	0.813845 (rank : 7)	NC score	0.037749 (rank : 7)
Query Neighborhood Hits	14	Target Neighborhood Hits	100	Shared Neighborhood Hits	2
SwissProt Accessions	O54786, O54787	Gene names	Dffa, Icad
Domain Architecture	No domain graphic available
Description	DNA fragmentation factor subunit alpha (DNA fragmentation factor 45 kDa subunit) (DFF-45) (Inhibitor of CAD) (ICAD).

SM1L2_HUMAN
θ value	1.06291 (rank : 8)	NC score	0.018471 (rank : 8)
Query Neighborhood Hits	14	Target Neighborhood Hits	1019	Shared Neighborhood Hits	3
SwissProt Accessions	Q8NDV3, Q5TIC3, Q9Y3G5	Gene names	SMC1L2
Domain Architecture
Description	Structural maintenance of chromosome 1-like 2 protein (SMC1beta protein).

TRI43_HUMAN
θ value	2.36792 (rank : 9)	NC score	0.013741 (rank : 10)
Query Neighborhood Hits	14	Target Neighborhood Hits	341	Shared Neighborhood Hits	3
SwissProt Accessions	Q96BQ3	Gene names	TRIM43
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 43.

DIAP2_MOUSE
θ value	3.0926 (rank : 10)	NC score	0.017912 (rank : 9)
Query Neighborhood Hits	14	Target Neighborhood Hits	260	Shared Neighborhood Hits	3
SwissProt Accessions	O70566, Q8C2G8	Gene names	Diaph2, Diap2
Domain Architecture
Description	Protein diaphanous homolog 2 (Diaphanous-related formin-2) (DRF2) (mDia3).

AMPN_MOUSE
θ value	5.27518 (rank : 11)	NC score	0.008702 (rank : 11)
Query Neighborhood Hits	14	Target Neighborhood Hits	34	Shared Neighborhood Hits	2
SwissProt Accessions	P97449, Q91YH8, Q99K63	Gene names	Anpep, Lap-1, Lap1
Domain Architecture
Description	Aminopeptidase N (EC 3.4.11.2) (mAPN) (Alanyl aminopeptidase) (Microsomal aminopeptidase) (Aminopeptidase M) (Membrane protein p161) (CD13 antigen).

ATS7_HUMAN
θ value	8.99809 (rank : 12)	NC score	0.003191 (rank : 14)
Query Neighborhood Hits	14	Target Neighborhood Hits	169	Shared Neighborhood Hits	2
SwissProt Accessions	Q9UKP4	Gene names	ADAMTS7
Domain Architecture
Description	ADAMTS-7 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase with thrombospondin motifs 7) (ADAM-TS 7) (ADAM-TS7).

HUWE1_HUMAN
θ value	8.99809 (rank : 13)	NC score	0.008065 (rank : 13)
Query Neighborhood Hits	14	Target Neighborhood Hits	443	Shared Neighborhood Hits	3
SwissProt Accessions	Q7Z6Z7, O15029, Q4G2Z2, Q5H961, Q6P4D0, Q8NG67, Q9BUI0, Q9HCJ4, Q9NSL6, Q9P0A9	Gene names	HUWE1, KIAA0312, KIAA1578, UREB1
Domain Architecture	No domain graphic available
Description	HECT, UBA and WWE domain-containing protein 1 (EC 6.3.2.-) (E3 ubiquitin protein ligase URE-B1) (Mcl-1 ubiquitin ligase E3) (Mule) (ARF-binding protein 1) (ARF-BP1).

HUWE1_MOUSE
θ value	8.99809 (rank : 14)	NC score	0.008089 (rank : 12)
Query Neighborhood Hits	14	Target Neighborhood Hits	406	Shared Neighborhood Hits	3
SwissProt Accessions	Q7TMY8, Q4G2Z1, Q5BMM7, Q6NS61, Q8BNJ7, Q8CFH2, Q8VD14, Q921M5, Q9R0P2	Gene names	Huwe1, Kiaa0312, Ureb1
Domain Architecture	No domain graphic available
Description	HECT, UBA and WWE domain-containing protein 1 (EC 6.3.2.-) (E3 ubiquitin protein ligase URE-B1) (E3Histone).

Hits sorted by NC score

DNL4_HUMAN
NC score	0.999962 (rank : 1)	θ value	0 (rank : 1)
Query Neighborhood Hits	14	Target Neighborhood Hits	14	Shared Neighborhood Hits	14
SwissProt Accessions	P49917, Q8IY66, Q8TEU5	Gene names	LIG4
Domain Architecture
Description	DNA ligase 4 (EC 6.5.1.1) (DNA ligase IV) (Polydeoxyribonucleotide synthase [ATP] 4).

DNL4_MOUSE
NC score	0.998148 (rank : 2)	θ value	0 (rank : 2)
Query Neighborhood Hits	14	Target Neighborhood Hits	17	Shared Neighborhood Hits	9
SwissProt Accessions	Q8BTF7, Q3UG76	Gene names	Lig4
Domain Architecture	No domain graphic available
Description	DNA ligase 4 (EC 6.5.1.1) (DNA ligase IV) (Polydeoxyribonucleotide synthase [ATP] 4).

DNL3_HUMAN
NC score	0.724692 (rank : 3)	θ value	7.04741e-37 (rank : 3)
Query Neighborhood Hits	14	Target Neighborhood Hits	49	Shared Neighborhood Hits	6
SwissProt Accessions	P49916, Q16714	Gene names	LIG3
Domain Architecture
Description	DNA ligase 3 (EC 6.5.1.1) (DNA ligase III) (Polydeoxyribonucleotide synthase [ATP] 3).

DNL3_MOUSE
NC score	0.715810 (rank : 4)	θ value	6.59618e-35 (rank : 4)
Query Neighborhood Hits	14	Target Neighborhood Hits	37	Shared Neighborhood Hits	6
SwissProt Accessions	P97386, P97385	Gene names	Lig3
Domain Architecture
Description	DNA ligase 3 (EC 6.5.1.1) (DNA ligase III) (Polydeoxyribonucleotide synthase [ATP] 3).

DNL1_MOUSE
NC score	0.679907 (rank : 5)	θ value	3.17079e-29 (rank : 5)
Query Neighborhood Hits	14	Target Neighborhood Hits	110	Shared Neighborhood Hits	6
SwissProt Accessions	P37913	Gene names	Lig1, Lig-1
Domain Architecture
Description	DNA ligase 1 (EC 6.5.1.1) (DNA ligase I) (Polydeoxyribonucleotide synthase [ATP] 1).

DNL1_HUMAN
NC score	0.652142 (rank : 6)	θ value	3.50572e-28 (rank : 6)
Query Neighborhood Hits	14	Target Neighborhood Hits	216	Shared Neighborhood Hits	6
SwissProt Accessions	P18858	Gene names	LIG1
Domain Architecture
Description	DNA ligase 1 (EC 6.5.1.1) (DNA ligase I) (Polydeoxyribonucleotide synthase [ATP] 1).

DFFA_MOUSE
NC score	0.037749 (rank : 7)	θ value	0.813845 (rank : 7)
Query Neighborhood Hits	14	Target Neighborhood Hits	100	Shared Neighborhood Hits	2
SwissProt Accessions	O54786, O54787	Gene names	Dffa, Icad
Domain Architecture	No domain graphic available
Description	DNA fragmentation factor subunit alpha (DNA fragmentation factor 45 kDa subunit) (DFF-45) (Inhibitor of CAD) (ICAD).

SM1L2_HUMAN
NC score	0.018471 (rank : 8)	θ value	1.06291 (rank : 8)
Query Neighborhood Hits	14	Target Neighborhood Hits	1019	Shared Neighborhood Hits	3
SwissProt Accessions	Q8NDV3, Q5TIC3, Q9Y3G5	Gene names	SMC1L2
Domain Architecture
Description	Structural maintenance of chromosome 1-like 2 protein (SMC1beta protein).

DIAP2_MOUSE
NC score	0.017912 (rank : 9)	θ value	3.0926 (rank : 10)
Query Neighborhood Hits	14	Target Neighborhood Hits	260	Shared Neighborhood Hits	3
SwissProt Accessions	O70566, Q8C2G8	Gene names	Diaph2, Diap2
Domain Architecture
Description	Protein diaphanous homolog 2 (Diaphanous-related formin-2) (DRF2) (mDia3).

TRI43_HUMAN
NC score	0.013741 (rank : 10)	θ value	2.36792 (rank : 9)
Query Neighborhood Hits	14	Target Neighborhood Hits	341	Shared Neighborhood Hits	3
SwissProt Accessions	Q96BQ3	Gene names	TRIM43
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 43.

AMPN_MOUSE
NC score	0.008702 (rank : 11)	θ value	5.27518 (rank : 11)
Query Neighborhood Hits	14	Target Neighborhood Hits	34	Shared Neighborhood Hits	2
SwissProt Accessions	P97449, Q91YH8, Q99K63	Gene names	Anpep, Lap-1, Lap1
Domain Architecture
Description	Aminopeptidase N (EC 3.4.11.2) (mAPN) (Alanyl aminopeptidase) (Microsomal aminopeptidase) (Aminopeptidase M) (Membrane protein p161) (CD13 antigen).

HUWE1_MOUSE
NC score	0.008089 (rank : 12)	θ value	8.99809 (rank : 14)
Query Neighborhood Hits	14	Target Neighborhood Hits	406	Shared Neighborhood Hits	3
SwissProt Accessions	Q7TMY8, Q4G2Z1, Q5BMM7, Q6NS61, Q8BNJ7, Q8CFH2, Q8VD14, Q921M5, Q9R0P2	Gene names	Huwe1, Kiaa0312, Ureb1
Domain Architecture	No domain graphic available
Description	HECT, UBA and WWE domain-containing protein 1 (EC 6.3.2.-) (E3 ubiquitin protein ligase URE-B1) (E3Histone).

HUWE1_HUMAN
NC score	0.008065 (rank : 13)	θ value	8.99809 (rank : 13)
Query Neighborhood Hits	14	Target Neighborhood Hits	443	Shared Neighborhood Hits	3
SwissProt Accessions	Q7Z6Z7, O15029, Q4G2Z2, Q5H961, Q6P4D0, Q8NG67, Q9BUI0, Q9HCJ4, Q9NSL6, Q9P0A9	Gene names	HUWE1, KIAA0312, KIAA1578, UREB1
Domain Architecture	No domain graphic available
Description	HECT, UBA and WWE domain-containing protein 1 (EC 6.3.2.-) (E3 ubiquitin protein ligase URE-B1) (Mcl-1 ubiquitin ligase E3) (Mule) (ARF-binding protein 1) (ARF-BP1).

ATS7_HUMAN
NC score	0.003191 (rank : 14)	θ value	8.99809 (rank : 12)
Query Neighborhood Hits	14	Target Neighborhood Hits	169	Shared Neighborhood Hits	2
SwissProt Accessions	Q9UKP4	Gene names	ADAMTS7
Domain Architecture
Description	ADAMTS-7 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase with thrombospondin motifs 7) (ADAM-TS 7) (ADAM-TS7).