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Network neighborhood for query Sequence : CRF_HUMAN

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CRF_HUMAN
SwissProt Accessions	P06850	Gene names	CRH
Domain Architecture
Description	Corticoliberin precursor (Corticotropin-releasing factor) (CRF) (Corticotropin-releasing hormone).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

CRF_MOUSE
θ value	4.24587e-58 (rank : 1)	NC score	0.988945 (rank : 2)
Query Neighborhood Hits	14	Target Neighborhood Hits	9	Shared Neighborhood Hits	5
SwissProt Accessions	Q8CIT0	Gene names	Crh
Domain Architecture	No domain graphic available
Description	Corticoliberin precursor (Corticotropin-releasing factor) (CRF) (Corticotropin-releasing hormone).

CRF_HUMAN
θ value	9.20422e-37 (rank : 2)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	14	Target Neighborhood Hits	14	Shared Neighborhood Hits	14
SwissProt Accessions	P06850	Gene names	CRH
Domain Architecture
Description	Corticoliberin precursor (Corticotropin-releasing factor) (CRF) (Corticotropin-releasing hormone).

UCN1_HUMAN
θ value	0.000786445 (rank : 3)	NC score	0.515423 (rank : 3)
Query Neighborhood Hits	14	Target Neighborhood Hits	7	Shared Neighborhood Hits	4
SwissProt Accessions	P55089	Gene names	UCN
Domain Architecture	No domain graphic available
Description	Urocortin precursor.

UCN1_MOUSE
θ value	0.000786445 (rank : 4)	NC score	0.495975 (rank : 4)
Query Neighborhood Hits	14	Target Neighborhood Hits	5	Shared Neighborhood Hits	4
SwissProt Accessions	P81615, O88390	Gene names	Ucn
Domain Architecture	No domain graphic available
Description	Urocortin precursor.

RNF25_MOUSE
θ value	2.36792 (rank : 5)	NC score	0.042776 (rank : 7)
Query Neighborhood Hits	14	Target Neighborhood Hits	106	Shared Neighborhood Hits	2
SwissProt Accessions	Q9QZR0, Q3TAL8, Q9DCW7	Gene names	Rnf25
Domain Architecture
Description	RING finger protein 25 (EC 6.3.2.-) (RING finger protein AO7).

LMA1L_HUMAN
θ value	5.27518 (rank : 6)	NC score	0.024808 (rank : 8)
Query Neighborhood Hits	14	Target Neighborhood Hits	20	Shared Neighborhood Hits	2
SwissProt Accessions	Q9HAT1, Q6UWN2	Gene names	LMAN1L, ERGL
Domain Architecture
Description	ERGIC-53-like protein precursor (ERGIC53-like protein) (Lectin, mannose-binding 1-like) (LMAN1-like protein).

ZO2_MOUSE
θ value	5.27518 (rank : 7)	NC score	0.015099 (rank : 10)
Query Neighborhood Hits	14	Target Neighborhood Hits	296	Shared Neighborhood Hits	2
SwissProt Accessions	Q9Z0U1, Q8K210	Gene names	Tjp2, Zo2
Domain Architecture
Description	Tight junction protein ZO-2 (Zonula occludens 2 protein) (Zona occludens 2 protein) (Tight junction protein 2).

RUNX1_MOUSE
θ value	6.88961 (rank : 8)	NC score	0.016665 (rank : 9)
Query Neighborhood Hits	14	Target Neighborhood Hits	93	Shared Neighborhood Hits	2
SwissProt Accessions	Q03347, O08598, Q62049, Q9ESB9, Q9ET65	Gene names	Runx1, Aml1, Cbfa2, Pebp2ab
Domain Architecture
Description	Runt-related transcription factor 1 (Core-binding factor, alpha 2 subunit) (CBF-alpha 2) (Acute myeloid leukemia 1 protein) (Oncogene AML-1) (Polyomavirus enhancer-binding protein 2 alpha B subunit) (PEBP2-alpha B) (PEA2-alpha B) (SL3-3 enhancer factor 1 alpha B subunit) (SL3/AKV core-binding factor alpha B subunit).

TCF7_MOUSE
θ value	6.88961 (rank : 9)	NC score	0.014572 (rank : 11)
Query Neighborhood Hits	14	Target Neighborhood Hits	277	Shared Neighborhood Hits	2
SwissProt Accessions	Q00417	Gene names	Tcf7, Tcf-1, Tcf1
Domain Architecture
Description	Transcription factor 7 (T-cell-specific transcription factor 1) (TCF- 1) (T-cell factor 1).

UCN2_HUMAN
θ value	6.88961 (rank : 10)	NC score	0.071015 (rank : 5)
Query Neighborhood Hits	14	Target Neighborhood Hits	5	Shared Neighborhood Hits	3
SwissProt Accessions	Q96RP3, Q9BUG0	Gene names	UCN2, SRP, URP
Domain Architecture	No domain graphic available
Description	Urocortin-2 precursor (Urocortin II) (Ucn II) (Stresscopin-related peptide) (Urocortin-related peptide).

FOXN3_HUMAN
θ value	8.99809 (rank : 11)	NC score	0.008494 (rank : 15)
Query Neighborhood Hits	14	Target Neighborhood Hits	121	Shared Neighborhood Hits	2
SwissProt Accessions	O00409, Q96II7, Q9UIE7	Gene names	CHES1, FOXN3
Domain Architecture
Description	Checkpoint suppressor 1 (Forkhead box protein N3).

PA24F_MOUSE
θ value	8.99809 (rank : 12)	NC score	0.011199 (rank : 13)
Query Neighborhood Hits	14	Target Neighborhood Hits	93	Shared Neighborhood Hits	2
SwissProt Accessions	Q50L41, Q80VQ8, Q80VV9	Gene names	Pla2g4f
Domain Architecture	No domain graphic available
Description	Cytosolic phospholipase A2 zeta (EC 3.1.1.4) (cPLA2-zeta) (Phospholipase A2 group IVF).

SMAD4_MOUSE
θ value	8.99809 (rank : 13)	NC score	0.011930 (rank : 12)
Query Neighborhood Hits	14	Target Neighborhood Hits	101	Shared Neighborhood Hits	2
SwissProt Accessions	P97471, Q9CW56	Gene names	Smad4, Dpc4, Madh4
Domain Architecture
Description	Mothers against decapentaplegic homolog 4 (SMAD 4) (Mothers against DPP homolog 4) (Deletion target in pancreatic carcinoma 4 homolog) (Smad4).

STAT2_MOUSE
θ value	8.99809 (rank : 14)	NC score	0.010984 (rank : 14)
Query Neighborhood Hits	14	Target Neighborhood Hits	175	Shared Neighborhood Hits	2
SwissProt Accessions	Q9WVL2, Q64188, Q64189, Q64250	Gene names	Stat2
Domain Architecture
Description	Signal transducer and activator of transcription 2.

UCN2_MOUSE
θ value	θ > 10 (rank : 15)	NC score	0.055502 (rank : 6)
Query Neighborhood Hits	14	Target Neighborhood Hits	7	Shared Neighborhood Hits	4
SwissProt Accessions	Q99ML8	Gene names	Ucn2
Domain Architecture	No domain graphic available
Description	Urocortin-2 precursor (Urocortin II) (Ucn II).

Hits sorted by NC score

CRF_HUMAN
NC score	0.999962 (rank : 1)	θ value	9.20422e-37 (rank : 2)
Query Neighborhood Hits	14	Target Neighborhood Hits	14	Shared Neighborhood Hits	14
SwissProt Accessions	P06850	Gene names	CRH
Domain Architecture
Description	Corticoliberin precursor (Corticotropin-releasing factor) (CRF) (Corticotropin-releasing hormone).

CRF_MOUSE
NC score	0.988945 (rank : 2)	θ value	4.24587e-58 (rank : 1)
Query Neighborhood Hits	14	Target Neighborhood Hits	9	Shared Neighborhood Hits	5
SwissProt Accessions	Q8CIT0	Gene names	Crh
Domain Architecture	No domain graphic available
Description	Corticoliberin precursor (Corticotropin-releasing factor) (CRF) (Corticotropin-releasing hormone).

UCN1_HUMAN
NC score	0.515423 (rank : 3)	θ value	0.000786445 (rank : 3)
Query Neighborhood Hits	14	Target Neighborhood Hits	7	Shared Neighborhood Hits	4
SwissProt Accessions	P55089	Gene names	UCN
Domain Architecture	No domain graphic available
Description	Urocortin precursor.

UCN1_MOUSE
NC score	0.495975 (rank : 4)	θ value	0.000786445 (rank : 4)
Query Neighborhood Hits	14	Target Neighborhood Hits	5	Shared Neighborhood Hits	4
SwissProt Accessions	P81615, O88390	Gene names	Ucn
Domain Architecture	No domain graphic available
Description	Urocortin precursor.

UCN2_HUMAN
NC score	0.071015 (rank : 5)	θ value	6.88961 (rank : 10)
Query Neighborhood Hits	14	Target Neighborhood Hits	5	Shared Neighborhood Hits	3
SwissProt Accessions	Q96RP3, Q9BUG0	Gene names	UCN2, SRP, URP
Domain Architecture	No domain graphic available
Description	Urocortin-2 precursor (Urocortin II) (Ucn II) (Stresscopin-related peptide) (Urocortin-related peptide).

UCN2_MOUSE
NC score	0.055502 (rank : 6)	θ value	θ > 10 (rank : 15)
Query Neighborhood Hits	14	Target Neighborhood Hits	7	Shared Neighborhood Hits	4
SwissProt Accessions	Q99ML8	Gene names	Ucn2
Domain Architecture	No domain graphic available
Description	Urocortin-2 precursor (Urocortin II) (Ucn II).

RNF25_MOUSE
NC score	0.042776 (rank : 7)	θ value	2.36792 (rank : 5)
Query Neighborhood Hits	14	Target Neighborhood Hits	106	Shared Neighborhood Hits	2
SwissProt Accessions	Q9QZR0, Q3TAL8, Q9DCW7	Gene names	Rnf25
Domain Architecture
Description	RING finger protein 25 (EC 6.3.2.-) (RING finger protein AO7).

LMA1L_HUMAN
NC score	0.024808 (rank : 8)	θ value	5.27518 (rank : 6)
Query Neighborhood Hits	14	Target Neighborhood Hits	20	Shared Neighborhood Hits	2
SwissProt Accessions	Q9HAT1, Q6UWN2	Gene names	LMAN1L, ERGL
Domain Architecture
Description	ERGIC-53-like protein precursor (ERGIC53-like protein) (Lectin, mannose-binding 1-like) (LMAN1-like protein).

RUNX1_MOUSE
NC score	0.016665 (rank : 9)	θ value	6.88961 (rank : 8)
Query Neighborhood Hits	14	Target Neighborhood Hits	93	Shared Neighborhood Hits	2
SwissProt Accessions	Q03347, O08598, Q62049, Q9ESB9, Q9ET65	Gene names	Runx1, Aml1, Cbfa2, Pebp2ab
Domain Architecture
Description	Runt-related transcription factor 1 (Core-binding factor, alpha 2 subunit) (CBF-alpha 2) (Acute myeloid leukemia 1 protein) (Oncogene AML-1) (Polyomavirus enhancer-binding protein 2 alpha B subunit) (PEBP2-alpha B) (PEA2-alpha B) (SL3-3 enhancer factor 1 alpha B subunit) (SL3/AKV core-binding factor alpha B subunit).

ZO2_MOUSE
NC score	0.015099 (rank : 10)	θ value	5.27518 (rank : 7)
Query Neighborhood Hits	14	Target Neighborhood Hits	296	Shared Neighborhood Hits	2
SwissProt Accessions	Q9Z0U1, Q8K210	Gene names	Tjp2, Zo2
Domain Architecture
Description	Tight junction protein ZO-2 (Zonula occludens 2 protein) (Zona occludens 2 protein) (Tight junction protein 2).

TCF7_MOUSE
NC score	0.014572 (rank : 11)	θ value	6.88961 (rank : 9)
Query Neighborhood Hits	14	Target Neighborhood Hits	277	Shared Neighborhood Hits	2
SwissProt Accessions	Q00417	Gene names	Tcf7, Tcf-1, Tcf1
Domain Architecture
Description	Transcription factor 7 (T-cell-specific transcription factor 1) (TCF- 1) (T-cell factor 1).

SMAD4_MOUSE
NC score	0.011930 (rank : 12)	θ value	8.99809 (rank : 13)
Query Neighborhood Hits	14	Target Neighborhood Hits	101	Shared Neighborhood Hits	2
SwissProt Accessions	P97471, Q9CW56	Gene names	Smad4, Dpc4, Madh4
Domain Architecture
Description	Mothers against decapentaplegic homolog 4 (SMAD 4) (Mothers against DPP homolog 4) (Deletion target in pancreatic carcinoma 4 homolog) (Smad4).

PA24F_MOUSE
NC score	0.011199 (rank : 13)	θ value	8.99809 (rank : 12)
Query Neighborhood Hits	14	Target Neighborhood Hits	93	Shared Neighborhood Hits	2
SwissProt Accessions	Q50L41, Q80VQ8, Q80VV9	Gene names	Pla2g4f
Domain Architecture	No domain graphic available
Description	Cytosolic phospholipase A2 zeta (EC 3.1.1.4) (cPLA2-zeta) (Phospholipase A2 group IVF).

STAT2_MOUSE
NC score	0.010984 (rank : 14)	θ value	8.99809 (rank : 14)
Query Neighborhood Hits	14	Target Neighborhood Hits	175	Shared Neighborhood Hits	2
SwissProt Accessions	Q9WVL2, Q64188, Q64189, Q64250	Gene names	Stat2
Domain Architecture
Description	Signal transducer and activator of transcription 2.

FOXN3_HUMAN
NC score	0.008494 (rank : 15)	θ value	8.99809 (rank : 11)
Query Neighborhood Hits	14	Target Neighborhood Hits	121	Shared Neighborhood Hits	2
SwissProt Accessions	O00409, Q96II7, Q9UIE7	Gene names	CHES1, FOXN3
Domain Architecture
Description	Checkpoint suppressor 1 (Forkhead box protein N3).