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Network neighborhood for query Sequence : ASM_HUMAN

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ASM_HUMAN
SwissProt Accessions	P17405, P17406, Q13811, Q16837, Q16841	Gene names	SMPD1, ASM
Domain Architecture
Description	Sphingomyelin phosphodiesterase precursor (EC 3.1.4.12) (Acid sphingomyelinase) (aSMase).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

ASM_HUMAN
θ value	0 (rank : 1)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	21	Target Neighborhood Hits	21	Shared Neighborhood Hits	21
SwissProt Accessions	P17405, P17406, Q13811, Q16837, Q16841	Gene names	SMPD1, ASM
Domain Architecture
Description	Sphingomyelin phosphodiesterase precursor (EC 3.1.4.12) (Acid sphingomyelinase) (aSMase).

ASM_MOUSE
θ value	0 (rank : 2)	NC score	0.997064 (rank : 2)
Query Neighborhood Hits	21	Target Neighborhood Hits	13	Shared Neighborhood Hits	9
SwissProt Accessions	Q04519, Q3UL52	Gene names	Smpd1, Asm
Domain Architecture
Description	Sphingomyelin phosphodiesterase precursor (EC 3.1.4.12) (Acid sphingomyelinase) (aSMase).

ASM3B_HUMAN
θ value	4.25575e-50 (rank : 3)	NC score	0.864107 (rank : 3)
Query Neighborhood Hits	21	Target Neighborhood Hits	9	Shared Neighborhood Hits	6
SwissProt Accessions	Q92485, Q5T0Z0, Q96CB7	Gene names	SMPDL3B, ASML3B
Domain Architecture
Description	Acid sphingomyelinase-like phosphodiesterase 3b precursor (EC 3.1.4.-) (ASM-like phosphodiesterase 3b).

ASM3B_MOUSE
θ value	2.85459e-46 (rank : 4)	NC score	0.857904 (rank : 4)
Query Neighborhood Hits	21	Target Neighborhood Hits	16	Shared Neighborhood Hits	6
SwissProt Accessions	P58242	Gene names	Smpdl3b, Asml3b
Domain Architecture
Description	Acid sphingomyelinase-like phosphodiesterase 3b precursor (EC 3.1.4.-) (ASM-like phosphodiesterase 3b).

ASM3A_MOUSE
θ value	3.15612e-45 (rank : 5)	NC score	0.852008 (rank : 5)
Query Neighborhood Hits	21	Target Neighborhood Hits	10	Shared Neighborhood Hits	6
SwissProt Accessions	P70158	Gene names	Smpdl3a, Asml3a
Domain Architecture
Description	Acid sphingomyelinase-like phosphodiesterase 3a precursor (EC 3.1.4.-) (ASM-like phosphodiesterase 3a).

ASM3A_HUMAN
θ value	8.59492e-43 (rank : 6)	NC score	0.848678 (rank : 6)
Query Neighborhood Hits	21	Target Neighborhood Hits	17	Shared Neighborhood Hits	6
SwissProt Accessions	Q92484, Q8WV13	Gene names	SMPDL3A, ASML3A
Domain Architecture	No domain graphic available
Description	Acid sphingomyelinase-like phosphodiesterase 3a precursor (EC 3.1.4.-) (ASM-like phosphodiesterase 3a).

ROBO4_HUMAN
θ value	0.365318 (rank : 7)	NC score	0.030636 (rank : 7)
Query Neighborhood Hits	21	Target Neighborhood Hits	364	Shared Neighborhood Hits	4
SwissProt Accessions	Q8WZ75, Q8TEG1, Q96JV6, Q9H718, Q9NWJ8	Gene names	ROBO4
Domain Architecture
Description	Roundabout homolog 4 precursor (Magic roundabout).

GBRR1_HUMAN
θ value	2.36792 (rank : 8)	NC score	0.007787 (rank : 17)
Query Neighborhood Hits	21	Target Neighborhood Hits	81	Shared Neighborhood Hits	2
SwissProt Accessions	P24046	Gene names	GABRR1
Domain Architecture
Description	Gamma-aminobutyric-acid receptor subunit rho-1 precursor (GABA(A) receptor subunit rho-1).

ATS13_HUMAN
θ value	4.03905 (rank : 9)	NC score	0.006947 (rank : 19)
Query Neighborhood Hits	21	Target Neighborhood Hits	238	Shared Neighborhood Hits	2
SwissProt Accessions	Q76LX8, Q6UY16, Q710F6, Q711T8, Q96L37, Q9H0G3	Gene names	ADAMTS13, C9orf8
Domain Architecture	No domain graphic available
Description	ADAMTS-13 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase with thrombospondin motifs 13) (ADAM-TS 13) (ADAM-TS13) (von Willebrand factor-cleaving protease) (vWF-cleaving protease) (vWF-CP).

MYOC_MOUSE
θ value	4.03905 (rank : 10)	NC score	0.011730 (rank : 14)
Query Neighborhood Hits	21	Target Neighborhood Hits	232	Shared Neighborhood Hits	2
SwissProt Accessions	O70624, O70289	Gene names	Myoc, Tigr
Domain Architecture
Description	Myocilin precursor (Trabecular meshwork-induced glucocorticoid response protein).

PCLO_HUMAN
θ value	4.03905 (rank : 11)	NC score	0.005802 (rank : 20)
Query Neighborhood Hits	21	Target Neighborhood Hits	2046	Shared Neighborhood Hits	2
SwissProt Accessions	Q9Y6V0, O43373, O60305, Q9BVC8, Q9UIV2, Q9Y6U9	Gene names	PCLO, ACZ, KIAA0559
Domain Architecture
Description	Protein piccolo (Aczonin).

ACOX3_HUMAN
θ value	5.27518 (rank : 12)	NC score	0.012887 (rank : 13)
Query Neighborhood Hits	21	Target Neighborhood Hits	33	Shared Neighborhood Hits	2
SwissProt Accessions	O15254	Gene names	ACOX3, BRCOX, PRCOX
Domain Architecture
Description	Acyl-coenzyme A oxidase 3, peroxisomal (EC 1.3.3.6) (Pristanoyl-CoA oxidase) (Branched-chain acyl-CoA oxidase) (BRCACox).

M3K10_HUMAN
θ value	5.27518 (rank : 13)	NC score	0.000311 (rank : 21)
Query Neighborhood Hits	21	Target Neighborhood Hits	1071	Shared Neighborhood Hits	2
SwissProt Accessions	Q02779, Q12761, Q14871	Gene names	MAP3K10, MLK2, MST
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 10 (EC 2.7.11.25) (Mixed lineage kinase 2) (Protein kinase MST).

RYR2_HUMAN
θ value	5.27518 (rank : 14)	NC score	0.011215 (rank : 16)
Query Neighborhood Hits	21	Target Neighborhood Hits	175	Shared Neighborhood Hits	2
SwissProt Accessions	Q92736, Q15411, Q546N8	Gene names	RYR2
Domain Architecture
Description	Ryanodine receptor 2 (Cardiac muscle-type ryanodine receptor) (RyR2) (RYR-2) (Cardiac muscle ryanodine receptor-calcium release channel) (hRYR-2).

LTBP3_HUMAN
θ value	6.88961 (rank : 15)	NC score	0.007762 (rank : 18)
Query Neighborhood Hits	21	Target Neighborhood Hits	502	Shared Neighborhood Hits	3
SwissProt Accessions	Q9NS15, O15107, Q96HB9, Q9H7K2, Q9UFN4	Gene names	LTBP3
Domain Architecture
Description	Latent-transforming growth factor beta-binding protein 3 precursor (LTBP-3).

ROBO4_MOUSE
θ value	6.88961 (rank : 16)	NC score	0.019534 (rank : 9)
Query Neighborhood Hits	21	Target Neighborhood Hits	358	Shared Neighborhood Hits	4
SwissProt Accessions	Q8C310, Q9DBW1	Gene names	Robo4
Domain Architecture
Description	Roundabout homolog 4 precursor.

SAP_HUMAN
θ value	6.88961 (rank : 17)	NC score	0.014950 (rank : 12)
Query Neighborhood Hits	21	Target Neighborhood Hits	26	Shared Neighborhood Hits	2
SwissProt Accessions	P07602, P07292, P15793, P78538, P78541, P78546, P78547, P78558, Q6IBQ6, Q92739, Q92740, Q92741, Q92742	Gene names	PSAP
Domain Architecture
Description	Proactivator polypeptide precursor [Contains: Saposin A (Protein A); Saposin B-Val; Saposin B (Sphingolipid activator protein 1) (SAP-1) (Cerebroside sulfate activator) (CSAct) (Dispersin) (Sulfatide/GM1 activator); Saposin C (Co-beta-glucosidase) (A1 activator) (Glucosylceramidase activator) (Sphingolipid activator protein 2) (SAP-2); Saposin D (Protein C) (Component C)].

CU069_HUMAN
θ value	8.99809 (rank : 18)	NC score	0.021679 (rank : 8)
Query Neighborhood Hits	21	Target Neighborhood Hits	10	Shared Neighborhood Hits	2
SwissProt Accessions	P58556	Gene names	C21orf69
Domain Architecture	No domain graphic available
Description	Protein C21orf69.

EF1B_HUMAN
θ value	8.99809 (rank : 19)	NC score	0.016653 (rank : 11)
Query Neighborhood Hits	21	Target Neighborhood Hits	13	Shared Neighborhood Hits	3
SwissProt Accessions	P24534, Q6IBH9	Gene names	EEF1B2, EEF1B, EF1B
Domain Architecture
Description	Elongation factor 1-beta (EF-1-beta).

EF1B_MOUSE
θ value	8.99809 (rank : 20)	NC score	0.016705 (rank : 10)
Query Neighborhood Hits	21	Target Neighborhood Hits	12	Shared Neighborhood Hits	3
SwissProt Accessions	O70251, Q3THP5, Q5SUH1, Q8CHS1, Q99L22, Q9CZD4	Gene names	Eef1b, Eef1b2
Domain Architecture
Description	Elongation factor 1-beta (EF-1-beta).

EXOC2_MOUSE
θ value	8.99809 (rank : 21)	NC score	0.011585 (rank : 15)
Query Neighborhood Hits	21	Target Neighborhood Hits	34	Shared Neighborhood Hits	2
SwissProt Accessions	Q9D4H1	Gene names	Exoc2, Sec5, Sec5l1
Domain Architecture
Description	Exocyst complex component 2 (Exocyst complex component Sec5).

Hits sorted by NC score

ASM_HUMAN
NC score	0.999962 (rank : 1)	θ value	0 (rank : 1)
Query Neighborhood Hits	21	Target Neighborhood Hits	21	Shared Neighborhood Hits	21
SwissProt Accessions	P17405, P17406, Q13811, Q16837, Q16841	Gene names	SMPD1, ASM
Domain Architecture
Description	Sphingomyelin phosphodiesterase precursor (EC 3.1.4.12) (Acid sphingomyelinase) (aSMase).

ASM_MOUSE
NC score	0.997064 (rank : 2)	θ value	0 (rank : 2)
Query Neighborhood Hits	21	Target Neighborhood Hits	13	Shared Neighborhood Hits	9
SwissProt Accessions	Q04519, Q3UL52	Gene names	Smpd1, Asm
Domain Architecture
Description	Sphingomyelin phosphodiesterase precursor (EC 3.1.4.12) (Acid sphingomyelinase) (aSMase).

ASM3B_HUMAN
NC score	0.864107 (rank : 3)	θ value	4.25575e-50 (rank : 3)
Query Neighborhood Hits	21	Target Neighborhood Hits	9	Shared Neighborhood Hits	6
SwissProt Accessions	Q92485, Q5T0Z0, Q96CB7	Gene names	SMPDL3B, ASML3B
Domain Architecture
Description	Acid sphingomyelinase-like phosphodiesterase 3b precursor (EC 3.1.4.-) (ASM-like phosphodiesterase 3b).

ASM3B_MOUSE
NC score	0.857904 (rank : 4)	θ value	2.85459e-46 (rank : 4)
Query Neighborhood Hits	21	Target Neighborhood Hits	16	Shared Neighborhood Hits	6
SwissProt Accessions	P58242	Gene names	Smpdl3b, Asml3b
Domain Architecture
Description	Acid sphingomyelinase-like phosphodiesterase 3b precursor (EC 3.1.4.-) (ASM-like phosphodiesterase 3b).

ASM3A_MOUSE
NC score	0.852008 (rank : 5)	θ value	3.15612e-45 (rank : 5)
Query Neighborhood Hits	21	Target Neighborhood Hits	10	Shared Neighborhood Hits	6
SwissProt Accessions	P70158	Gene names	Smpdl3a, Asml3a
Domain Architecture
Description	Acid sphingomyelinase-like phosphodiesterase 3a precursor (EC 3.1.4.-) (ASM-like phosphodiesterase 3a).

ASM3A_HUMAN
NC score	0.848678 (rank : 6)	θ value	8.59492e-43 (rank : 6)
Query Neighborhood Hits	21	Target Neighborhood Hits	17	Shared Neighborhood Hits	6
SwissProt Accessions	Q92484, Q8WV13	Gene names	SMPDL3A, ASML3A
Domain Architecture	No domain graphic available
Description	Acid sphingomyelinase-like phosphodiesterase 3a precursor (EC 3.1.4.-) (ASM-like phosphodiesterase 3a).

ROBO4_HUMAN
NC score	0.030636 (rank : 7)	θ value	0.365318 (rank : 7)
Query Neighborhood Hits	21	Target Neighborhood Hits	364	Shared Neighborhood Hits	4
SwissProt Accessions	Q8WZ75, Q8TEG1, Q96JV6, Q9H718, Q9NWJ8	Gene names	ROBO4
Domain Architecture
Description	Roundabout homolog 4 precursor (Magic roundabout).

CU069_HUMAN
NC score	0.021679 (rank : 8)	θ value	8.99809 (rank : 18)
Query Neighborhood Hits	21	Target Neighborhood Hits	10	Shared Neighborhood Hits	2
SwissProt Accessions	P58556	Gene names	C21orf69
Domain Architecture	No domain graphic available
Description	Protein C21orf69.

ROBO4_MOUSE
NC score	0.019534 (rank : 9)	θ value	6.88961 (rank : 16)
Query Neighborhood Hits	21	Target Neighborhood Hits	358	Shared Neighborhood Hits	4
SwissProt Accessions	Q8C310, Q9DBW1	Gene names	Robo4
Domain Architecture
Description	Roundabout homolog 4 precursor.

EF1B_MOUSE
NC score	0.016705 (rank : 10)	θ value	8.99809 (rank : 20)
Query Neighborhood Hits	21	Target Neighborhood Hits	12	Shared Neighborhood Hits	3
SwissProt Accessions	O70251, Q3THP5, Q5SUH1, Q8CHS1, Q99L22, Q9CZD4	Gene names	Eef1b, Eef1b2
Domain Architecture
Description	Elongation factor 1-beta (EF-1-beta).

EF1B_HUMAN
NC score	0.016653 (rank : 11)	θ value	8.99809 (rank : 19)
Query Neighborhood Hits	21	Target Neighborhood Hits	13	Shared Neighborhood Hits	3
SwissProt Accessions	P24534, Q6IBH9	Gene names	EEF1B2, EEF1B, EF1B
Domain Architecture
Description	Elongation factor 1-beta (EF-1-beta).

SAP_HUMAN
NC score	0.014950 (rank : 12)	θ value	6.88961 (rank : 17)
Query Neighborhood Hits	21	Target Neighborhood Hits	26	Shared Neighborhood Hits	2
SwissProt Accessions	P07602, P07292, P15793, P78538, P78541, P78546, P78547, P78558, Q6IBQ6, Q92739, Q92740, Q92741, Q92742	Gene names	PSAP
Domain Architecture
Description	Proactivator polypeptide precursor [Contains: Saposin A (Protein A); Saposin B-Val; Saposin B (Sphingolipid activator protein 1) (SAP-1) (Cerebroside sulfate activator) (CSAct) (Dispersin) (Sulfatide/GM1 activator); Saposin C (Co-beta-glucosidase) (A1 activator) (Glucosylceramidase activator) (Sphingolipid activator protein 2) (SAP-2); Saposin D (Protein C) (Component C)].

ACOX3_HUMAN
NC score	0.012887 (rank : 13)	θ value	5.27518 (rank : 12)
Query Neighborhood Hits	21	Target Neighborhood Hits	33	Shared Neighborhood Hits	2
SwissProt Accessions	O15254	Gene names	ACOX3, BRCOX, PRCOX
Domain Architecture
Description	Acyl-coenzyme A oxidase 3, peroxisomal (EC 1.3.3.6) (Pristanoyl-CoA oxidase) (Branched-chain acyl-CoA oxidase) (BRCACox).

MYOC_MOUSE
NC score	0.011730 (rank : 14)	θ value	4.03905 (rank : 10)
Query Neighborhood Hits	21	Target Neighborhood Hits	232	Shared Neighborhood Hits	2
SwissProt Accessions	O70624, O70289	Gene names	Myoc, Tigr
Domain Architecture
Description	Myocilin precursor (Trabecular meshwork-induced glucocorticoid response protein).

EXOC2_MOUSE
NC score	0.011585 (rank : 15)	θ value	8.99809 (rank : 21)
Query Neighborhood Hits	21	Target Neighborhood Hits	34	Shared Neighborhood Hits	2
SwissProt Accessions	Q9D4H1	Gene names	Exoc2, Sec5, Sec5l1
Domain Architecture
Description	Exocyst complex component 2 (Exocyst complex component Sec5).

RYR2_HUMAN
NC score	0.011215 (rank : 16)	θ value	5.27518 (rank : 14)
Query Neighborhood Hits	21	Target Neighborhood Hits	175	Shared Neighborhood Hits	2
SwissProt Accessions	Q92736, Q15411, Q546N8	Gene names	RYR2
Domain Architecture
Description	Ryanodine receptor 2 (Cardiac muscle-type ryanodine receptor) (RyR2) (RYR-2) (Cardiac muscle ryanodine receptor-calcium release channel) (hRYR-2).

GBRR1_HUMAN
NC score	0.007787 (rank : 17)	θ value	2.36792 (rank : 8)
Query Neighborhood Hits	21	Target Neighborhood Hits	81	Shared Neighborhood Hits	2
SwissProt Accessions	P24046	Gene names	GABRR1
Domain Architecture
Description	Gamma-aminobutyric-acid receptor subunit rho-1 precursor (GABA(A) receptor subunit rho-1).

LTBP3_HUMAN
NC score	0.007762 (rank : 18)	θ value	6.88961 (rank : 15)
Query Neighborhood Hits	21	Target Neighborhood Hits	502	Shared Neighborhood Hits	3
SwissProt Accessions	Q9NS15, O15107, Q96HB9, Q9H7K2, Q9UFN4	Gene names	LTBP3
Domain Architecture
Description	Latent-transforming growth factor beta-binding protein 3 precursor (LTBP-3).

ATS13_HUMAN
NC score	0.006947 (rank : 19)	θ value	4.03905 (rank : 9)
Query Neighborhood Hits	21	Target Neighborhood Hits	238	Shared Neighborhood Hits	2
SwissProt Accessions	Q76LX8, Q6UY16, Q710F6, Q711T8, Q96L37, Q9H0G3	Gene names	ADAMTS13, C9orf8
Domain Architecture	No domain graphic available
Description	ADAMTS-13 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase with thrombospondin motifs 13) (ADAM-TS 13) (ADAM-TS13) (von Willebrand factor-cleaving protease) (vWF-cleaving protease) (vWF-CP).

PCLO_HUMAN
NC score	0.005802 (rank : 20)	θ value	4.03905 (rank : 11)
Query Neighborhood Hits	21	Target Neighborhood Hits	2046	Shared Neighborhood Hits	2
SwissProt Accessions	Q9Y6V0, O43373, O60305, Q9BVC8, Q9UIV2, Q9Y6U9	Gene names	PCLO, ACZ, KIAA0559
Domain Architecture
Description	Protein piccolo (Aczonin).

M3K10_HUMAN
NC score	0.000311 (rank : 21)	θ value	5.27518 (rank : 13)
Query Neighborhood Hits	21	Target Neighborhood Hits	1071	Shared Neighborhood Hits	2
SwissProt Accessions	Q02779, Q12761, Q14871	Gene names	MAP3K10, MLK2, MST
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 10 (EC 2.7.11.25) (Mixed lineage kinase 2) (Protein kinase MST).