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Network neighborhood for query Sequence : ASM_MOUSE

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ASM_MOUSE
SwissProt Accessions	Q04519, Q3UL52	Gene names	Smpd1, Asm
Domain Architecture
Description	Sphingomyelin phosphodiesterase precursor (EC 3.1.4.12) (Acid sphingomyelinase) (aSMase).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

ASM_HUMAN
θ value	0 (rank : 1)	NC score	0.997064 (rank : 2)
Query Neighborhood Hits	13	Target Neighborhood Hits	21	Shared Neighborhood Hits	9
SwissProt Accessions	P17405, P17406, Q13811, Q16837, Q16841	Gene names	SMPD1, ASM
Domain Architecture
Description	Sphingomyelin phosphodiesterase precursor (EC 3.1.4.12) (Acid sphingomyelinase) (aSMase).

ASM_MOUSE
θ value	0 (rank : 2)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	13	Target Neighborhood Hits	13	Shared Neighborhood Hits	13
SwissProt Accessions	Q04519, Q3UL52	Gene names	Smpd1, Asm
Domain Architecture
Description	Sphingomyelin phosphodiesterase precursor (EC 3.1.4.12) (Acid sphingomyelinase) (aSMase).

ASM3B_HUMAN
θ value	3.2585e-50 (rank : 3)	NC score	0.866161 (rank : 3)
Query Neighborhood Hits	13	Target Neighborhood Hits	9	Shared Neighborhood Hits	6
SwissProt Accessions	Q92485, Q5T0Z0, Q96CB7	Gene names	SMPDL3B, ASML3B
Domain Architecture
Description	Acid sphingomyelinase-like phosphodiesterase 3b precursor (EC 3.1.4.-) (ASM-like phosphodiesterase 3b).

ASM3B_MOUSE
θ value	3.04986e-48 (rank : 4)	NC score	0.860346 (rank : 4)
Query Neighborhood Hits	13	Target Neighborhood Hits	16	Shared Neighborhood Hits	6
SwissProt Accessions	P58242	Gene names	Smpdl3b, Asml3b
Domain Architecture
Description	Acid sphingomyelinase-like phosphodiesterase 3b precursor (EC 3.1.4.-) (ASM-like phosphodiesterase 3b).

ASM3A_MOUSE
θ value	3.15612e-45 (rank : 5)	NC score	0.854234 (rank : 5)
Query Neighborhood Hits	13	Target Neighborhood Hits	10	Shared Neighborhood Hits	6
SwissProt Accessions	P70158	Gene names	Smpdl3a, Asml3a
Domain Architecture
Description	Acid sphingomyelinase-like phosphodiesterase 3a precursor (EC 3.1.4.-) (ASM-like phosphodiesterase 3a).

ASM3A_HUMAN
θ value	4.122e-45 (rank : 6)	NC score	0.851333 (rank : 6)
Query Neighborhood Hits	13	Target Neighborhood Hits	17	Shared Neighborhood Hits	6
SwissProt Accessions	Q92484, Q8WV13	Gene names	SMPDL3A, ASML3A
Domain Architecture	No domain graphic available
Description	Acid sphingomyelinase-like phosphodiesterase 3a precursor (EC 3.1.4.-) (ASM-like phosphodiesterase 3a).

PPA5_HUMAN
θ value	0.125558 (rank : 7)	NC score	0.060173 (rank : 7)
Query Neighborhood Hits	13	Target Neighborhood Hits	5	Shared Neighborhood Hits	2
SwissProt Accessions	P13686, Q6IAS6	Gene names	ACP5
Domain Architecture
Description	Tartrate-resistant acid phosphatase type 5 precursor (EC 3.1.3.2) (TR- AP) (Tartrate-resistant acid ATPase) (TrATPase) (Acid phosphatase 5, tartrate resistant).

ROBO4_HUMAN
θ value	0.47712 (rank : 8)	NC score	0.031169 (rank : 8)
Query Neighborhood Hits	13	Target Neighborhood Hits	364	Shared Neighborhood Hits	4
SwissProt Accessions	Q8WZ75, Q8TEG1, Q96JV6, Q9H718, Q9NWJ8	Gene names	ROBO4
Domain Architecture
Description	Roundabout homolog 4 precursor (Magic roundabout).

LTBP3_HUMAN
θ value	0.62314 (rank : 9)	NC score	0.011682 (rank : 11)
Query Neighborhood Hits	13	Target Neighborhood Hits	502	Shared Neighborhood Hits	4
SwissProt Accessions	Q9NS15, O15107, Q96HB9, Q9H7K2, Q9UFN4	Gene names	LTBP3
Domain Architecture
Description	Latent-transforming growth factor beta-binding protein 3 precursor (LTBP-3).

ROBO4_MOUSE
θ value	4.03905 (rank : 10)	NC score	0.020302 (rank : 9)
Query Neighborhood Hits	13	Target Neighborhood Hits	358	Shared Neighborhood Hits	4
SwissProt Accessions	Q8C310, Q9DBW1	Gene names	Robo4
Domain Architecture
Description	Roundabout homolog 4 precursor.

MKS3_HUMAN
θ value	6.88961 (rank : 11)	NC score	0.013508 (rank : 10)
Query Neighborhood Hits	13	Target Neighborhood Hits	79	Shared Neighborhood Hits	2
SwissProt Accessions	Q5HYA8, Q3ZCX3, Q7Z5T8, Q8IZ06	Gene names	TMEM67, MKS3
Domain Architecture	No domain graphic available
Description	Meckelin (Meckel syndrome type 3 protein) (Transmembrane protein 67).

MASP2_MOUSE
θ value	8.99809 (rank : 12)	NC score	0.001908 (rank : 13)
Query Neighborhood Hits	13	Target Neighborhood Hits	382	Shared Neighborhood Hits	3
SwissProt Accessions	Q91WP0, Q9QXA4, Q9QXD2, Q9QXD5, Q9Z338	Gene names	Masp2
Domain Architecture	No domain graphic available
Description	Mannan-binding lectin serine protease 2 precursor (EC 3.4.21.104) (Mannose-binding protein-associated serine protease 2) (MASP-2) (MBL- associated serine protease 2) [Contains: Mannan-binding lectin serine protease 2 A chain; Mannan-binding lectin serine protease 2 B chain].

SUMF2_MOUSE
θ value	8.99809 (rank : 13)	NC score	0.011135 (rank : 12)
Query Neighborhood Hits	13	Target Neighborhood Hits	6	Shared Neighborhood Hits	2
SwissProt Accessions	Q8BPG6, Q9CZ47	Gene names	Sumf2
Domain Architecture
Description	Sulfatase-modifying factor 2 precursor (C-alpha-formyglycine- generating enzyme 2).

Hits sorted by NC score

ASM_MOUSE
NC score	0.999962 (rank : 1)	θ value	0 (rank : 2)
Query Neighborhood Hits	13	Target Neighborhood Hits	13	Shared Neighborhood Hits	13
SwissProt Accessions	Q04519, Q3UL52	Gene names	Smpd1, Asm
Domain Architecture
Description	Sphingomyelin phosphodiesterase precursor (EC 3.1.4.12) (Acid sphingomyelinase) (aSMase).

ASM_HUMAN
NC score	0.997064 (rank : 2)	θ value	0 (rank : 1)
Query Neighborhood Hits	13	Target Neighborhood Hits	21	Shared Neighborhood Hits	9
SwissProt Accessions	P17405, P17406, Q13811, Q16837, Q16841	Gene names	SMPD1, ASM
Domain Architecture
Description	Sphingomyelin phosphodiesterase precursor (EC 3.1.4.12) (Acid sphingomyelinase) (aSMase).

ASM3B_HUMAN
NC score	0.866161 (rank : 3)	θ value	3.2585e-50 (rank : 3)
Query Neighborhood Hits	13	Target Neighborhood Hits	9	Shared Neighborhood Hits	6
SwissProt Accessions	Q92485, Q5T0Z0, Q96CB7	Gene names	SMPDL3B, ASML3B
Domain Architecture
Description	Acid sphingomyelinase-like phosphodiesterase 3b precursor (EC 3.1.4.-) (ASM-like phosphodiesterase 3b).

ASM3B_MOUSE
NC score	0.860346 (rank : 4)	θ value	3.04986e-48 (rank : 4)
Query Neighborhood Hits	13	Target Neighborhood Hits	16	Shared Neighborhood Hits	6
SwissProt Accessions	P58242	Gene names	Smpdl3b, Asml3b
Domain Architecture
Description	Acid sphingomyelinase-like phosphodiesterase 3b precursor (EC 3.1.4.-) (ASM-like phosphodiesterase 3b).

ASM3A_MOUSE
NC score	0.854234 (rank : 5)	θ value	3.15612e-45 (rank : 5)
Query Neighborhood Hits	13	Target Neighborhood Hits	10	Shared Neighborhood Hits	6
SwissProt Accessions	P70158	Gene names	Smpdl3a, Asml3a
Domain Architecture
Description	Acid sphingomyelinase-like phosphodiesterase 3a precursor (EC 3.1.4.-) (ASM-like phosphodiesterase 3a).

ASM3A_HUMAN
NC score	0.851333 (rank : 6)	θ value	4.122e-45 (rank : 6)
Query Neighborhood Hits	13	Target Neighborhood Hits	17	Shared Neighborhood Hits	6
SwissProt Accessions	Q92484, Q8WV13	Gene names	SMPDL3A, ASML3A
Domain Architecture	No domain graphic available
Description	Acid sphingomyelinase-like phosphodiesterase 3a precursor (EC 3.1.4.-) (ASM-like phosphodiesterase 3a).

PPA5_HUMAN
NC score	0.060173 (rank : 7)	θ value	0.125558 (rank : 7)
Query Neighborhood Hits	13	Target Neighborhood Hits	5	Shared Neighborhood Hits	2
SwissProt Accessions	P13686, Q6IAS6	Gene names	ACP5
Domain Architecture
Description	Tartrate-resistant acid phosphatase type 5 precursor (EC 3.1.3.2) (TR- AP) (Tartrate-resistant acid ATPase) (TrATPase) (Acid phosphatase 5, tartrate resistant).

ROBO4_HUMAN
NC score	0.031169 (rank : 8)	θ value	0.47712 (rank : 8)
Query Neighborhood Hits	13	Target Neighborhood Hits	364	Shared Neighborhood Hits	4
SwissProt Accessions	Q8WZ75, Q8TEG1, Q96JV6, Q9H718, Q9NWJ8	Gene names	ROBO4
Domain Architecture
Description	Roundabout homolog 4 precursor (Magic roundabout).

ROBO4_MOUSE
NC score	0.020302 (rank : 9)	θ value	4.03905 (rank : 10)
Query Neighborhood Hits	13	Target Neighborhood Hits	358	Shared Neighborhood Hits	4
SwissProt Accessions	Q8C310, Q9DBW1	Gene names	Robo4
Domain Architecture
Description	Roundabout homolog 4 precursor.

MKS3_HUMAN
NC score	0.013508 (rank : 10)	θ value	6.88961 (rank : 11)
Query Neighborhood Hits	13	Target Neighborhood Hits	79	Shared Neighborhood Hits	2
SwissProt Accessions	Q5HYA8, Q3ZCX3, Q7Z5T8, Q8IZ06	Gene names	TMEM67, MKS3
Domain Architecture	No domain graphic available
Description	Meckelin (Meckel syndrome type 3 protein) (Transmembrane protein 67).

LTBP3_HUMAN
NC score	0.011682 (rank : 11)	θ value	0.62314 (rank : 9)
Query Neighborhood Hits	13	Target Neighborhood Hits	502	Shared Neighborhood Hits	4
SwissProt Accessions	Q9NS15, O15107, Q96HB9, Q9H7K2, Q9UFN4	Gene names	LTBP3
Domain Architecture
Description	Latent-transforming growth factor beta-binding protein 3 precursor (LTBP-3).

SUMF2_MOUSE
NC score	0.011135 (rank : 12)	θ value	8.99809 (rank : 13)
Query Neighborhood Hits	13	Target Neighborhood Hits	6	Shared Neighborhood Hits	2
SwissProt Accessions	Q8BPG6, Q9CZ47	Gene names	Sumf2
Domain Architecture
Description	Sulfatase-modifying factor 2 precursor (C-alpha-formyglycine- generating enzyme 2).

MASP2_MOUSE
NC score	0.001908 (rank : 13)	θ value	8.99809 (rank : 12)
Query Neighborhood Hits	13	Target Neighborhood Hits	382	Shared Neighborhood Hits	3
SwissProt Accessions	Q91WP0, Q9QXA4, Q9QXD2, Q9QXD5, Q9Z338	Gene names	Masp2
Domain Architecture	No domain graphic available
Description	Mannan-binding lectin serine protease 2 precursor (EC 3.4.21.104) (Mannose-binding protein-associated serine protease 2) (MASP-2) (MBL- associated serine protease 2) [Contains: Mannan-binding lectin serine protease 2 A chain; Mannan-binding lectin serine protease 2 B chain].