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Network neighborhood for query Sequence : 3BHS4_MOUSE

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3BHS4_MOUSE
SwissProt Accessions	Q61767	Gene names	Hsd3b4
Domain Architecture
Description	3 beta-hydroxysteroid dehydrogenase type 4 (3 beta-hydroxysteroid dehydrogenase type IV) (3Beta-HSD IV) (NADPH-dependent 3-beta-hydroxy- delta(5)-steroid dehydrogenase) (EC 1.1.1.-) (3-beta-hydroxy-5-ene steroid dehydrogenase) (Progesterone reductase).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

3BHS4_MOUSE
θ value	0 (rank : 1)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	17	Target Neighborhood Hits	17	Shared Neighborhood Hits	17
SwissProt Accessions	Q61767	Gene names	Hsd3b4
Domain Architecture
Description	3 beta-hydroxysteroid dehydrogenase type 4 (3 beta-hydroxysteroid dehydrogenase type IV) (3Beta-HSD IV) (NADPH-dependent 3-beta-hydroxy- delta(5)-steroid dehydrogenase) (EC 1.1.1.-) (3-beta-hydroxy-5-ene steroid dehydrogenase) (Progesterone reductase).

3BHS5_MOUSE
θ value	0 (rank : 2)	NC score	0.999667 (rank : 2)
Query Neighborhood Hits	17	Target Neighborhood Hits	18	Shared Neighborhood Hits	17
SwissProt Accessions	Q61694, Q91X27	Gene names	Hsd3b5
Domain Architecture
Description	3 beta-hydroxysteroid dehydrogenase type 5 (3 beta-hydroxysteroid dehydrogenase type V) (3Beta-HSD V) (NADPH-dependent 3-beta-hydroxy- delta(5)-steroid dehydrogenase) (EC 1.1.1.-) (3-beta-hydroxy-5-ene steroid dehydrogenase) (Progesterone reductase).

3BHS2_MOUSE
θ value	1.37145e-157 (rank : 3)	NC score	0.996610 (rank : 5)
Query Neighborhood Hits	17	Target Neighborhood Hits	20	Shared Neighborhood Hits	16
SwissProt Accessions	P26149, Q8R0J6	Gene names	Hsd3b2
Domain Architecture
Description	3 beta-hydroxysteroid dehydrogenase/delta 5-->4-isomerase type II (3Beta-HSD II) [Includes: 3-beta-hydroxy-delta(5)-steroid dehydrogenase (EC 1.1.1.145) (3-beta-hydroxy-5-ene steroid dehydrogenase) (Progesterone reductase); Steroid delta-isomerase (EC 5.3.3.1) (Delta-5-3-ketosteroid isomerase)].

3BHS6_MOUSE
θ value	1.79118e-157 (rank : 4)	NC score	0.996777 (rank : 4)
Query Neighborhood Hits	17	Target Neighborhood Hits	25	Shared Neighborhood Hits	16
SwissProt Accessions	O35469	Gene names	Hsd3b6
Domain Architecture
Description	3 beta-hydroxysteroid dehydrogenase/delta 5-->4-isomerase type VI (3Beta-HSD VI) [Includes: 3-beta-hydroxy-delta(5)-steroid dehydrogenase (EC 1.1.1.145) (3-beta-hydroxy-5-ene steroid dehydrogenase) (Progesterone reductase); Steroid delta-isomerase (EC 5.3.3.1) (Delta-5-3-ketosteroid isomerase)].

3BHS3_MOUSE
θ value	3.99034e-157 (rank : 5)	NC score	0.996003 (rank : 6)
Query Neighborhood Hits	17	Target Neighborhood Hits	23	Shared Neighborhood Hits	16
SwissProt Accessions	P26150	Gene names	Hsd3b3
Domain Architecture	No domain graphic available
Description	3 beta-hydroxysteroid dehydrogenase/delta 5-->4-isomerase type III (3Beta-HSD III) [Includes: 3-beta-hydroxy-delta(5)-steroid dehydrogenase (EC 1.1.1.145) (3-beta-hydroxy-5-ene steroid dehydrogenase) (Progesterone reductase); Steroid delta-isomerase (EC 5.3.3.1) (Delta-5-3-ketosteroid isomerase)].

3BHS1_MOUSE
θ value	5.04779e-152 (rank : 6)	NC score	0.997282 (rank : 3)
Query Neighborhood Hits	17	Target Neighborhood Hits	21	Shared Neighborhood Hits	16
SwissProt Accessions	P24815, Q7TQ00	Gene names	Hsd3b1, Hsd3b
Domain Architecture
Description	3 beta-hydroxysteroid dehydrogenase/delta 5-->4-isomerase type I (3Beta-HSD I) [Includes: 3-beta-hydroxy-delta(5)-steroid dehydrogenase (EC 1.1.1.145) (3-beta-hydroxy-5-ene steroid dehydrogenase) (Progesterone reductase); Steroid delta-isomerase (EC 5.3.3.1) (Delta- 5-3-ketosteroid isomerase)].

3BHS1_HUMAN
θ value	1.37464e-149 (rank : 7)	NC score	0.994934 (rank : 8)
Query Neighborhood Hits	17	Target Neighborhood Hits	19	Shared Neighborhood Hits	16
SwissProt Accessions	P14060, Q14545, Q8IV65	Gene names	HSD3B1, 3BH, HSDB3A
Domain Architecture
Description	3 beta-hydroxysteroid dehydrogenase/delta 5-->4-isomerase type I (3Beta-HSD I) (Trophoblast antigen FDO161G) [Includes: 3-beta-hydroxy- delta(5)-steroid dehydrogenase (EC 1.1.1.145) (3-beta-hydroxy-5-ene steroid dehydrogenase) (Progesterone reductase); Steroid delta- isomerase (EC 5.3.3.1) (Delta-5-3-ketosteroid isomerase)].

3BHS2_HUMAN
θ value	2.689e-137 (rank : 8)	NC score	0.995769 (rank : 7)
Query Neighborhood Hits	17	Target Neighborhood Hits	16	Shared Neighborhood Hits	16
SwissProt Accessions	P26439, Q16010, Q53GD4, Q6LDB9	Gene names	HSD3B2, HSDB3B
Domain Architecture
Description	3 beta-hydroxysteroid dehydrogenase/delta 5-->4-isomerase type II (3Beta-HSD II) [Includes: 3-beta-hydroxy-delta(5)-steroid dehydrogenase (EC 1.1.1.145) (3-beta-hydroxy-5-ene steroid dehydrogenase) (Progesterone reductase); Steroid delta-isomerase (EC 5.3.3.1) (Delta-5-3-ketosteroid isomerase)].

3BHS7_MOUSE
θ value	4.85792e-54 (rank : 9)	NC score	0.946793 (rank : 10)
Query Neighborhood Hits	17	Target Neighborhood Hits	21	Shared Neighborhood Hits	16
SwissProt Accessions	Q9EQC1	Gene names	Hsd3b7
Domain Architecture
Description	3 beta-hydroxysteroid dehydrogenase type 7 (3 beta-hydroxysteroid dehydrogenase type VII) (3Beta-HSD VII) (3-beta-hydroxy-delta(5)-C27 steroid oxidoreductase) (EC 1.1.1.-) (C(27) 3beta-HSD).

3BHS7_HUMAN
θ value	1.41344e-53 (rank : 10)	NC score	0.947736 (rank : 9)
Query Neighborhood Hits	17	Target Neighborhood Hits	20	Shared Neighborhood Hits	16
SwissProt Accessions	Q9H2F3, Q9BSN9	Gene names	HSD3B7
Domain Architecture
Description	3 beta-hydroxysteroid dehydrogenase type 7 (3 beta-hydroxysteroid dehydrogenase type VII) (3Beta-HSD VII) (3-beta-hydroxy-delta(5)-C27 steroid oxidoreductase) (EC 1.1.1.-) (C(27) 3beta-HSD).

NSDHL_HUMAN
θ value	1.24977e-17 (rank : 11)	NC score	0.780677 (rank : 11)
Query Neighborhood Hits	17	Target Neighborhood Hits	27	Shared Neighborhood Hits	16
SwissProt Accessions	Q15738, O00344	Gene names	NSDHL, H105E3
Domain Architecture
Description	Sterol-4-alpha-carboxylate 3-dehydrogenase, decarboxylating (EC 1.1.1.170) (H105e3 protein).

NSDHL_MOUSE
θ value	4.02038e-16 (rank : 12)	NC score	0.779432 (rank : 12)
Query Neighborhood Hits	17	Target Neighborhood Hits	25	Shared Neighborhood Hits	16
SwissProt Accessions	Q9R1J0, O55109	Gene names	Nsdhl
Domain Architecture
Description	Sterol-4-alpha-carboxylate 3-dehydrogenase, decarboxylating (EC 1.1.1.170).

TGDS_HUMAN
θ value	4.92598e-06 (rank : 13)	NC score	0.448166 (rank : 13)
Query Neighborhood Hits	17	Target Neighborhood Hits	23	Shared Neighborhood Hits	16
SwissProt Accessions	O95455, Q5T3Z2, Q9H1T9	Gene names	TGDS
Domain Architecture
Description	dTDP-D-glucose 4,6-dehydratase (EC 4.2.1.46).

TGDS_MOUSE
θ value	6.43352e-06 (rank : 14)	NC score	0.444062 (rank : 14)
Query Neighborhood Hits	17	Target Neighborhood Hits	26	Shared Neighborhood Hits	16
SwissProt Accessions	Q8VDR7	Gene names	Tgds
Domain Architecture
Description	dTDP-D-glucose 4,6-dehydratase (EC 4.2.1.46).

GALE_HUMAN
θ value	1.87187e-05 (rank : 15)	NC score	0.362686 (rank : 15)
Query Neighborhood Hits	17	Target Neighborhood Hits	25	Shared Neighborhood Hits	16
SwissProt Accessions	Q14376, Q86W41, Q9BVE3, Q9UJB4	Gene names	GALE
Domain Architecture
Description	UDP-glucose 4-epimerase (EC 5.1.3.2) (Galactowaldenase) (UDP-galactose 4-epimerase).

GALE_MOUSE
θ value	0.000270298 (rank : 16)	NC score	0.316283 (rank : 16)
Query Neighborhood Hits	17	Target Neighborhood Hits	28	Shared Neighborhood Hits	16
SwissProt Accessions	Q8R059	Gene names	Gale
Domain Architecture
Description	UDP-glucose 4-epimerase (EC 5.1.3.2) (Galactowaldenase) (UDP-galactose 4-epimerase).

RPGR1_HUMAN
θ value	4.03905 (rank : 17)	NC score	0.009669 (rank : 19)
Query Neighborhood Hits	17	Target Neighborhood Hits	578	Shared Neighborhood Hits	3
SwissProt Accessions	Q96KN7, Q7Z2W6, Q8IXV5, Q96QA8, Q9HB94, Q9HB95, Q9HBK6, Q9NR40	Gene names	RPGRIP1
Domain Architecture
Description	X-linked retinitis pigmentosa GTPase regulator-interacting protein 1 (RPGR-interacting protein 1).

UXS1_HUMAN
θ value	θ > 10 (rank : 18)	NC score	0.098697 (rank : 18)
Query Neighborhood Hits	17	Target Neighborhood Hits	19	Shared Neighborhood Hits	8
SwissProt Accessions	Q8NBZ7, Q8NBX3, Q9H5C2	Gene names	UXS1
Domain Architecture	No domain graphic available
Description	UDP-glucuronic acid decarboxylase 1 (EC 4.1.1.35) (UDP-glucuronate decarboxylase 1) (UGD) (UXS-1).

UXS1_MOUSE
θ value	θ > 10 (rank : 19)	NC score	0.099094 (rank : 17)
Query Neighborhood Hits	17	Target Neighborhood Hits	19	Shared Neighborhood Hits	8
SwissProt Accessions	Q91XL3, Q3U854	Gene names	Uxs1
Domain Architecture	No domain graphic available
Description	UDP-glucuronic acid decarboxylase 1 (EC 4.1.1.35) (UDP-glucuronate decarboxylase 1) (UGD) (UXS-1).

Hits sorted by NC score

3BHS4_MOUSE
NC score	0.999962 (rank : 1)	θ value	0 (rank : 1)
Query Neighborhood Hits	17	Target Neighborhood Hits	17	Shared Neighborhood Hits	17
SwissProt Accessions	Q61767	Gene names	Hsd3b4
Domain Architecture
Description	3 beta-hydroxysteroid dehydrogenase type 4 (3 beta-hydroxysteroid dehydrogenase type IV) (3Beta-HSD IV) (NADPH-dependent 3-beta-hydroxy- delta(5)-steroid dehydrogenase) (EC 1.1.1.-) (3-beta-hydroxy-5-ene steroid dehydrogenase) (Progesterone reductase).

3BHS5_MOUSE
NC score	0.999667 (rank : 2)	θ value	0 (rank : 2)
Query Neighborhood Hits	17	Target Neighborhood Hits	18	Shared Neighborhood Hits	17
SwissProt Accessions	Q61694, Q91X27	Gene names	Hsd3b5
Domain Architecture
Description	3 beta-hydroxysteroid dehydrogenase type 5 (3 beta-hydroxysteroid dehydrogenase type V) (3Beta-HSD V) (NADPH-dependent 3-beta-hydroxy- delta(5)-steroid dehydrogenase) (EC 1.1.1.-) (3-beta-hydroxy-5-ene steroid dehydrogenase) (Progesterone reductase).

3BHS1_MOUSE
NC score	0.997282 (rank : 3)	θ value	5.04779e-152 (rank : 6)
Query Neighborhood Hits	17	Target Neighborhood Hits	21	Shared Neighborhood Hits	16
SwissProt Accessions	P24815, Q7TQ00	Gene names	Hsd3b1, Hsd3b
Domain Architecture
Description	3 beta-hydroxysteroid dehydrogenase/delta 5-->4-isomerase type I (3Beta-HSD I) [Includes: 3-beta-hydroxy-delta(5)-steroid dehydrogenase (EC 1.1.1.145) (3-beta-hydroxy-5-ene steroid dehydrogenase) (Progesterone reductase); Steroid delta-isomerase (EC 5.3.3.1) (Delta- 5-3-ketosteroid isomerase)].

3BHS6_MOUSE
NC score	0.996777 (rank : 4)	θ value	1.79118e-157 (rank : 4)
Query Neighborhood Hits	17	Target Neighborhood Hits	25	Shared Neighborhood Hits	16
SwissProt Accessions	O35469	Gene names	Hsd3b6
Domain Architecture
Description	3 beta-hydroxysteroid dehydrogenase/delta 5-->4-isomerase type VI (3Beta-HSD VI) [Includes: 3-beta-hydroxy-delta(5)-steroid dehydrogenase (EC 1.1.1.145) (3-beta-hydroxy-5-ene steroid dehydrogenase) (Progesterone reductase); Steroid delta-isomerase (EC 5.3.3.1) (Delta-5-3-ketosteroid isomerase)].

3BHS2_MOUSE
NC score	0.996610 (rank : 5)	θ value	1.37145e-157 (rank : 3)
Query Neighborhood Hits	17	Target Neighborhood Hits	20	Shared Neighborhood Hits	16
SwissProt Accessions	P26149, Q8R0J6	Gene names	Hsd3b2
Domain Architecture
Description	3 beta-hydroxysteroid dehydrogenase/delta 5-->4-isomerase type II (3Beta-HSD II) [Includes: 3-beta-hydroxy-delta(5)-steroid dehydrogenase (EC 1.1.1.145) (3-beta-hydroxy-5-ene steroid dehydrogenase) (Progesterone reductase); Steroid delta-isomerase (EC 5.3.3.1) (Delta-5-3-ketosteroid isomerase)].

3BHS3_MOUSE
NC score	0.996003 (rank : 6)	θ value	3.99034e-157 (rank : 5)
Query Neighborhood Hits	17	Target Neighborhood Hits	23	Shared Neighborhood Hits	16
SwissProt Accessions	P26150	Gene names	Hsd3b3
Domain Architecture	No domain graphic available
Description	3 beta-hydroxysteroid dehydrogenase/delta 5-->4-isomerase type III (3Beta-HSD III) [Includes: 3-beta-hydroxy-delta(5)-steroid dehydrogenase (EC 1.1.1.145) (3-beta-hydroxy-5-ene steroid dehydrogenase) (Progesterone reductase); Steroid delta-isomerase (EC 5.3.3.1) (Delta-5-3-ketosteroid isomerase)].

3BHS2_HUMAN
NC score	0.995769 (rank : 7)	θ value	2.689e-137 (rank : 8)
Query Neighborhood Hits	17	Target Neighborhood Hits	16	Shared Neighborhood Hits	16
SwissProt Accessions	P26439, Q16010, Q53GD4, Q6LDB9	Gene names	HSD3B2, HSDB3B
Domain Architecture
Description	3 beta-hydroxysteroid dehydrogenase/delta 5-->4-isomerase type II (3Beta-HSD II) [Includes: 3-beta-hydroxy-delta(5)-steroid dehydrogenase (EC 1.1.1.145) (3-beta-hydroxy-5-ene steroid dehydrogenase) (Progesterone reductase); Steroid delta-isomerase (EC 5.3.3.1) (Delta-5-3-ketosteroid isomerase)].

3BHS1_HUMAN
NC score	0.994934 (rank : 8)	θ value	1.37464e-149 (rank : 7)
Query Neighborhood Hits	17	Target Neighborhood Hits	19	Shared Neighborhood Hits	16
SwissProt Accessions	P14060, Q14545, Q8IV65	Gene names	HSD3B1, 3BH, HSDB3A
Domain Architecture
Description	3 beta-hydroxysteroid dehydrogenase/delta 5-->4-isomerase type I (3Beta-HSD I) (Trophoblast antigen FDO161G) [Includes: 3-beta-hydroxy- delta(5)-steroid dehydrogenase (EC 1.1.1.145) (3-beta-hydroxy-5-ene steroid dehydrogenase) (Progesterone reductase); Steroid delta- isomerase (EC 5.3.3.1) (Delta-5-3-ketosteroid isomerase)].

3BHS7_HUMAN
NC score	0.947736 (rank : 9)	θ value	1.41344e-53 (rank : 10)
Query Neighborhood Hits	17	Target Neighborhood Hits	20	Shared Neighborhood Hits	16
SwissProt Accessions	Q9H2F3, Q9BSN9	Gene names	HSD3B7
Domain Architecture
Description	3 beta-hydroxysteroid dehydrogenase type 7 (3 beta-hydroxysteroid dehydrogenase type VII) (3Beta-HSD VII) (3-beta-hydroxy-delta(5)-C27 steroid oxidoreductase) (EC 1.1.1.-) (C(27) 3beta-HSD).

3BHS7_MOUSE
NC score	0.946793 (rank : 10)	θ value	4.85792e-54 (rank : 9)
Query Neighborhood Hits	17	Target Neighborhood Hits	21	Shared Neighborhood Hits	16
SwissProt Accessions	Q9EQC1	Gene names	Hsd3b7
Domain Architecture
Description	3 beta-hydroxysteroid dehydrogenase type 7 (3 beta-hydroxysteroid dehydrogenase type VII) (3Beta-HSD VII) (3-beta-hydroxy-delta(5)-C27 steroid oxidoreductase) (EC 1.1.1.-) (C(27) 3beta-HSD).

NSDHL_HUMAN
NC score	0.780677 (rank : 11)	θ value	1.24977e-17 (rank : 11)
Query Neighborhood Hits	17	Target Neighborhood Hits	27	Shared Neighborhood Hits	16
SwissProt Accessions	Q15738, O00344	Gene names	NSDHL, H105E3
Domain Architecture
Description	Sterol-4-alpha-carboxylate 3-dehydrogenase, decarboxylating (EC 1.1.1.170) (H105e3 protein).

NSDHL_MOUSE
NC score	0.779432 (rank : 12)	θ value	4.02038e-16 (rank : 12)
Query Neighborhood Hits	17	Target Neighborhood Hits	25	Shared Neighborhood Hits	16
SwissProt Accessions	Q9R1J0, O55109	Gene names	Nsdhl
Domain Architecture
Description	Sterol-4-alpha-carboxylate 3-dehydrogenase, decarboxylating (EC 1.1.1.170).

TGDS_HUMAN
NC score	0.448166 (rank : 13)	θ value	4.92598e-06 (rank : 13)
Query Neighborhood Hits	17	Target Neighborhood Hits	23	Shared Neighborhood Hits	16
SwissProt Accessions	O95455, Q5T3Z2, Q9H1T9	Gene names	TGDS
Domain Architecture
Description	dTDP-D-glucose 4,6-dehydratase (EC 4.2.1.46).

TGDS_MOUSE
NC score	0.444062 (rank : 14)	θ value	6.43352e-06 (rank : 14)
Query Neighborhood Hits	17	Target Neighborhood Hits	26	Shared Neighborhood Hits	16
SwissProt Accessions	Q8VDR7	Gene names	Tgds
Domain Architecture
Description	dTDP-D-glucose 4,6-dehydratase (EC 4.2.1.46).

GALE_HUMAN
NC score	0.362686 (rank : 15)	θ value	1.87187e-05 (rank : 15)
Query Neighborhood Hits	17	Target Neighborhood Hits	25	Shared Neighborhood Hits	16
SwissProt Accessions	Q14376, Q86W41, Q9BVE3, Q9UJB4	Gene names	GALE
Domain Architecture
Description	UDP-glucose 4-epimerase (EC 5.1.3.2) (Galactowaldenase) (UDP-galactose 4-epimerase).

GALE_MOUSE
NC score	0.316283 (rank : 16)	θ value	0.000270298 (rank : 16)
Query Neighborhood Hits	17	Target Neighborhood Hits	28	Shared Neighborhood Hits	16
SwissProt Accessions	Q8R059	Gene names	Gale
Domain Architecture
Description	UDP-glucose 4-epimerase (EC 5.1.3.2) (Galactowaldenase) (UDP-galactose 4-epimerase).

UXS1_MOUSE
NC score	0.099094 (rank : 17)	θ value	θ > 10 (rank : 19)
Query Neighborhood Hits	17	Target Neighborhood Hits	19	Shared Neighborhood Hits	8
SwissProt Accessions	Q91XL3, Q3U854	Gene names	Uxs1
Domain Architecture	No domain graphic available
Description	UDP-glucuronic acid decarboxylase 1 (EC 4.1.1.35) (UDP-glucuronate decarboxylase 1) (UGD) (UXS-1).

UXS1_HUMAN
NC score	0.098697 (rank : 18)	θ value	θ > 10 (rank : 18)
Query Neighborhood Hits	17	Target Neighborhood Hits	19	Shared Neighborhood Hits	8
SwissProt Accessions	Q8NBZ7, Q8NBX3, Q9H5C2	Gene names	UXS1
Domain Architecture	No domain graphic available
Description	UDP-glucuronic acid decarboxylase 1 (EC 4.1.1.35) (UDP-glucuronate decarboxylase 1) (UGD) (UXS-1).

RPGR1_HUMAN
NC score	0.009669 (rank : 19)	θ value	4.03905 (rank : 17)
Query Neighborhood Hits	17	Target Neighborhood Hits	578	Shared Neighborhood Hits	3
SwissProt Accessions	Q96KN7, Q7Z2W6, Q8IXV5, Q96QA8, Q9HB94, Q9HB95, Q9HBK6, Q9NR40	Gene names	RPGRIP1
Domain Architecture
Description	X-linked retinitis pigmentosa GTPase regulator-interacting protein 1 (RPGR-interacting protein 1).