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Network neighborhood for query Sequence : VMDL1_HUMAN

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VMDL1_HUMAN
SwissProt Accessions	Q8NFU1, Q9NXP0	Gene names	VMD2L1
Domain Architecture
Description	Bestrophin-2 (Vitelliform macular dystrophy 2-like protein 1).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

VMDL1_HUMAN
θ value	0 (rank : 1)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	19	Target Neighborhood Hits	19	Shared Neighborhood Hits	19
SwissProt Accessions	Q8NFU1, Q9NXP0	Gene names	VMD2L1
Domain Architecture
Description	Bestrophin-2 (Vitelliform macular dystrophy 2-like protein 1).

VMDL1_MOUSE
θ value	0 (rank : 2)	NC score	0.997522 (rank : 2)
Query Neighborhood Hits	19	Target Neighborhood Hits	19	Shared Neighborhood Hits	8
SwissProt Accessions	Q8BGM5, Q8VCM0	Gene names	Vmd2l1
Domain Architecture
Description	Bestrophin-2 (Vitelliform macular dystrophy 2-like protein 1).

VMDL3_MOUSE
θ value	6.60789e-144 (rank : 3)	NC score	0.982151 (rank : 6)
Query Neighborhood Hits	19	Target Neighborhood Hits	30	Shared Neighborhood Hits	7
SwissProt Accessions	Q6H1V1	Gene names	Vmd2l3
Domain Architecture	No domain graphic available
Description	Bestrophin-4 (Vitelliform macular dystrophy 2-like protein 3).

VMDL3_HUMAN
θ value	8.63019e-144 (rank : 4)	NC score	0.981301 (rank : 7)
Query Neighborhood Hits	19	Target Neighborhood Hits	32	Shared Neighborhood Hits	8
SwissProt Accessions	Q8N1M1, Q8N356, Q8NFT9, Q9BR80	Gene names	VMD2L3
Domain Architecture
Description	Bestrophin-4 (Vitelliform macular dystrophy 2-like protein 3).

VMDL2_HUMAN
θ value	5.59392e-143 (rank : 5)	NC score	0.992571 (rank : 3)
Query Neighborhood Hits	19	Target Neighborhood Hits	8	Shared Neighborhood Hits	7
SwissProt Accessions	Q8NFU0	Gene names	VMD2L2
Domain Architecture
Description	Bestrophin-3 (Vitelliform macular dystrophy 2-like protein 2).

VMD2_HUMAN
θ value	2.35023e-141 (rank : 6)	NC score	0.983462 (rank : 5)
Query Neighborhood Hits	19	Target Neighborhood Hits	26	Shared Neighborhood Hits	7
SwissProt Accessions	O76090, O75904, Q8IUR9, Q8IZ80	Gene names	VMD2
Domain Architecture
Description	Bestrophin-1 (Vitelliform macular dystrophy protein 2) (TU15B).

VMD2_MOUSE
θ value	4.74654e-134 (rank : 7)	NC score	0.985313 (rank : 4)
Query Neighborhood Hits	19	Target Neighborhood Hits	15	Shared Neighborhood Hits	7
SwissProt Accessions	O88870, Q6H1V0	Gene names	Vmd2, Bmd1
Domain Architecture	No domain graphic available
Description	Bestrophin-1 (Vitelliform macular dystrophy protein 2 homolog).

NRX2A_HUMAN
θ value	0.813845 (rank : 8)	NC score	0.017212 (rank : 9)
Query Neighborhood Hits	19	Target Neighborhood Hits	614	Shared Neighborhood Hits	5
SwissProt Accessions	Q9P2S2, Q9Y2D6	Gene names	NRXN2, KIAA0921
Domain Architecture
Description	Neurexin-2-alpha precursor (Neurexin II-alpha).

NRX2B_HUMAN
θ value	0.813845 (rank : 9)	NC score	0.024112 (rank : 8)
Query Neighborhood Hits	19	Target Neighborhood Hits	481	Shared Neighborhood Hits	5
SwissProt Accessions	P58401	Gene names	NRXN2
Domain Architecture	No domain graphic available
Description	Neurexin-2-beta precursor (Neurexin II-beta).

HCN2_HUMAN
θ value	1.06291 (rank : 10)	NC score	0.010978 (rank : 14)
Query Neighborhood Hits	19	Target Neighborhood Hits	369	Shared Neighborhood Hits	6
SwissProt Accessions	Q9UL51, O60742, O60743, O75267, Q9UBS2	Gene names	HCN2, BCNG2
Domain Architecture
Description	Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 (Brain cyclic nucleotide-gated channel 2) (BCNG-2).

ERF_HUMAN
θ value	2.36792 (rank : 11)	NC score	0.015076 (rank : 12)
Query Neighborhood Hits	19	Target Neighborhood Hits	162	Shared Neighborhood Hits	4
SwissProt Accessions	P50548, Q9UPI7	Gene names	ERF
Domain Architecture
Description	ETS domain-containing transcription factor ERF (Ets2 repressor factor).

ERF_MOUSE
θ value	2.36792 (rank : 12)	NC score	0.015126 (rank : 11)
Query Neighborhood Hits	19	Target Neighborhood Hits	160	Shared Neighborhood Hits	4
SwissProt Accessions	P70459	Gene names	Erf
Domain Architecture
Description	ETS domain-containing transcription factor ERF.

GSC_HUMAN
θ value	2.36792 (rank : 13)	NC score	0.005480 (rank : 16)
Query Neighborhood Hits	19	Target Neighborhood Hits	369	Shared Neighborhood Hits	2
SwissProt Accessions	P56915, Q86YR1	Gene names	GSC
Domain Architecture	No domain graphic available
Description	Homeobox protein goosecoid.

TM108_MOUSE
θ value	4.03905 (rank : 14)	NC score	0.013294 (rank : 13)
Query Neighborhood Hits	19	Target Neighborhood Hits	336	Shared Neighborhood Hits	3
SwissProt Accessions	Q8BHE4, Q80WR9	Gene names	Tmem108
Domain Architecture	No domain graphic available
Description	Transmembrane protein 108 precursor.

WNK2_HUMAN
θ value	4.03905 (rank : 15)	NC score	0.001550 (rank : 17)
Query Neighborhood Hits	19	Target Neighborhood Hits	1407	Shared Neighborhood Hits	6
SwissProt Accessions	Q9Y3S1, Q8IY36, Q9C0A3, Q9H3P4	Gene names	WNK2, KIAA1760, PRKWNK2
Domain Architecture
Description	Serine/threonine-protein kinase WNK2 (EC 2.7.11.1) (Protein kinase with no lysine 2) (Protein kinase, lysine-deficient 2).

SON_HUMAN
θ value	5.27518 (rank : 16)	NC score	0.016349 (rank : 10)
Query Neighborhood Hits	19	Target Neighborhood Hits	1568	Shared Neighborhood Hits	11
SwissProt Accessions	P18583, O14487, O95981, Q14120, Q9H7B1, Q9P070, Q9P072, Q9UKP9, Q9UPY0	Gene names	SON, C21orf50, DBP5, KIAA1019, NREBP
Domain Architecture
Description	SON protein (SON3) (Negative regulatory element-binding protein) (NRE- binding protein) (DBP-5) (Bax antagonist selected in saccharomyces 1) (BASS1).

BC11B_HUMAN
θ value	8.99809 (rank : 17)	NC score	0.000596 (rank : 18)
Query Neighborhood Hits	19	Target Neighborhood Hits	761	Shared Neighborhood Hits	4
SwissProt Accessions	Q9C0K0, Q9H162	Gene names	BCL11B, CTIP2, RIT1
Domain Architecture	No domain graphic available
Description	B-cell lymphoma/leukemia 11B (B-cell CLL/lymphoma 11B) (Radiation- induced tumor suppressor gene 1 protein) (hRit1) (COUP-TF-interacting protein 2).

BC11B_MOUSE
θ value	8.99809 (rank : 18)	NC score	0.000565 (rank : 19)
Query Neighborhood Hits	19	Target Neighborhood Hits	767	Shared Neighborhood Hits	4
SwissProt Accessions	Q99PV8, Q8C2I1, Q99PV6, Q99PV7, Q9JLF8	Gene names	Bcl11b, Ctip2, Rit1
Domain Architecture	No domain graphic available
Description	B-cell lymphoma/leukemia 11B (B-cell CLL/lymphoma 11B) (Radiation- induced tumor suppressor gene 1 protein) (mRit1) (COUP-TF-interacting protein 2).

DNMT1_MOUSE
θ value	8.99809 (rank : 19)	NC score	0.007354 (rank : 15)
Query Neighborhood Hits	19	Target Neighborhood Hits	137	Shared Neighborhood Hits	2
SwissProt Accessions	P13864, P97413, Q80ZU3, Q9CSC6, Q9QXX6	Gene names	Dnmt1, Dnmt, Met1, Uim
Domain Architecture
Description	DNA (cytosine-5)-methyltransferase 1 (EC 2.1.1.37) (Dnmt1) (DNA methyltransferase MmuI) (DNA MTase MmuI) (MCMT) (M.MmuI) (Met-1).

Hits sorted by NC score

VMDL1_HUMAN
NC score	0.999962 (rank : 1)	θ value	0 (rank : 1)
Query Neighborhood Hits	19	Target Neighborhood Hits	19	Shared Neighborhood Hits	19
SwissProt Accessions	Q8NFU1, Q9NXP0	Gene names	VMD2L1
Domain Architecture
Description	Bestrophin-2 (Vitelliform macular dystrophy 2-like protein 1).

VMDL1_MOUSE
NC score	0.997522 (rank : 2)	θ value	0 (rank : 2)
Query Neighborhood Hits	19	Target Neighborhood Hits	19	Shared Neighborhood Hits	8
SwissProt Accessions	Q8BGM5, Q8VCM0	Gene names	Vmd2l1
Domain Architecture
Description	Bestrophin-2 (Vitelliform macular dystrophy 2-like protein 1).

VMDL2_HUMAN
NC score	0.992571 (rank : 3)	θ value	5.59392e-143 (rank : 5)
Query Neighborhood Hits	19	Target Neighborhood Hits	8	Shared Neighborhood Hits	7
SwissProt Accessions	Q8NFU0	Gene names	VMD2L2
Domain Architecture
Description	Bestrophin-3 (Vitelliform macular dystrophy 2-like protein 2).

VMD2_MOUSE
NC score	0.985313 (rank : 4)	θ value	4.74654e-134 (rank : 7)
Query Neighborhood Hits	19	Target Neighborhood Hits	15	Shared Neighborhood Hits	7
SwissProt Accessions	O88870, Q6H1V0	Gene names	Vmd2, Bmd1
Domain Architecture	No domain graphic available
Description	Bestrophin-1 (Vitelliform macular dystrophy protein 2 homolog).

VMD2_HUMAN
NC score	0.983462 (rank : 5)	θ value	2.35023e-141 (rank : 6)
Query Neighborhood Hits	19	Target Neighborhood Hits	26	Shared Neighborhood Hits	7
SwissProt Accessions	O76090, O75904, Q8IUR9, Q8IZ80	Gene names	VMD2
Domain Architecture
Description	Bestrophin-1 (Vitelliform macular dystrophy protein 2) (TU15B).

VMDL3_MOUSE
NC score	0.982151 (rank : 6)	θ value	6.60789e-144 (rank : 3)
Query Neighborhood Hits	19	Target Neighborhood Hits	30	Shared Neighborhood Hits	7
SwissProt Accessions	Q6H1V1	Gene names	Vmd2l3
Domain Architecture	No domain graphic available
Description	Bestrophin-4 (Vitelliform macular dystrophy 2-like protein 3).

VMDL3_HUMAN
NC score	0.981301 (rank : 7)	θ value	8.63019e-144 (rank : 4)
Query Neighborhood Hits	19	Target Neighborhood Hits	32	Shared Neighborhood Hits	8
SwissProt Accessions	Q8N1M1, Q8N356, Q8NFT9, Q9BR80	Gene names	VMD2L3
Domain Architecture
Description	Bestrophin-4 (Vitelliform macular dystrophy 2-like protein 3).

NRX2B_HUMAN
NC score	0.024112 (rank : 8)	θ value	0.813845 (rank : 9)
Query Neighborhood Hits	19	Target Neighborhood Hits	481	Shared Neighborhood Hits	5
SwissProt Accessions	P58401	Gene names	NRXN2
Domain Architecture	No domain graphic available
Description	Neurexin-2-beta precursor (Neurexin II-beta).

NRX2A_HUMAN
NC score	0.017212 (rank : 9)	θ value	0.813845 (rank : 8)
Query Neighborhood Hits	19	Target Neighborhood Hits	614	Shared Neighborhood Hits	5
SwissProt Accessions	Q9P2S2, Q9Y2D6	Gene names	NRXN2, KIAA0921
Domain Architecture
Description	Neurexin-2-alpha precursor (Neurexin II-alpha).

SON_HUMAN
NC score	0.016349 (rank : 10)	θ value	5.27518 (rank : 16)
Query Neighborhood Hits	19	Target Neighborhood Hits	1568	Shared Neighborhood Hits	11
SwissProt Accessions	P18583, O14487, O95981, Q14120, Q9H7B1, Q9P070, Q9P072, Q9UKP9, Q9UPY0	Gene names	SON, C21orf50, DBP5, KIAA1019, NREBP
Domain Architecture
Description	SON protein (SON3) (Negative regulatory element-binding protein) (NRE- binding protein) (DBP-5) (Bax antagonist selected in saccharomyces 1) (BASS1).

ERF_MOUSE
NC score	0.015126 (rank : 11)	θ value	2.36792 (rank : 12)
Query Neighborhood Hits	19	Target Neighborhood Hits	160	Shared Neighborhood Hits	4
SwissProt Accessions	P70459	Gene names	Erf
Domain Architecture
Description	ETS domain-containing transcription factor ERF.

ERF_HUMAN
NC score	0.015076 (rank : 12)	θ value	2.36792 (rank : 11)
Query Neighborhood Hits	19	Target Neighborhood Hits	162	Shared Neighborhood Hits	4
SwissProt Accessions	P50548, Q9UPI7	Gene names	ERF
Domain Architecture
Description	ETS domain-containing transcription factor ERF (Ets2 repressor factor).

TM108_MOUSE
NC score	0.013294 (rank : 13)	θ value	4.03905 (rank : 14)
Query Neighborhood Hits	19	Target Neighborhood Hits	336	Shared Neighborhood Hits	3
SwissProt Accessions	Q8BHE4, Q80WR9	Gene names	Tmem108
Domain Architecture	No domain graphic available
Description	Transmembrane protein 108 precursor.

HCN2_HUMAN
NC score	0.010978 (rank : 14)	θ value	1.06291 (rank : 10)
Query Neighborhood Hits	19	Target Neighborhood Hits	369	Shared Neighborhood Hits	6
SwissProt Accessions	Q9UL51, O60742, O60743, O75267, Q9UBS2	Gene names	HCN2, BCNG2
Domain Architecture
Description	Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 (Brain cyclic nucleotide-gated channel 2) (BCNG-2).

DNMT1_MOUSE
NC score	0.007354 (rank : 15)	θ value	8.99809 (rank : 19)
Query Neighborhood Hits	19	Target Neighborhood Hits	137	Shared Neighborhood Hits	2
SwissProt Accessions	P13864, P97413, Q80ZU3, Q9CSC6, Q9QXX6	Gene names	Dnmt1, Dnmt, Met1, Uim
Domain Architecture
Description	DNA (cytosine-5)-methyltransferase 1 (EC 2.1.1.37) (Dnmt1) (DNA methyltransferase MmuI) (DNA MTase MmuI) (MCMT) (M.MmuI) (Met-1).

GSC_HUMAN
NC score	0.005480 (rank : 16)	θ value	2.36792 (rank : 13)
Query Neighborhood Hits	19	Target Neighborhood Hits	369	Shared Neighborhood Hits	2
SwissProt Accessions	P56915, Q86YR1	Gene names	GSC
Domain Architecture	No domain graphic available
Description	Homeobox protein goosecoid.

WNK2_HUMAN
NC score	0.001550 (rank : 17)	θ value	4.03905 (rank : 15)
Query Neighborhood Hits	19	Target Neighborhood Hits	1407	Shared Neighborhood Hits	6
SwissProt Accessions	Q9Y3S1, Q8IY36, Q9C0A3, Q9H3P4	Gene names	WNK2, KIAA1760, PRKWNK2
Domain Architecture
Description	Serine/threonine-protein kinase WNK2 (EC 2.7.11.1) (Protein kinase with no lysine 2) (Protein kinase, lysine-deficient 2).

BC11B_HUMAN
NC score	0.000596 (rank : 18)	θ value	8.99809 (rank : 17)
Query Neighborhood Hits	19	Target Neighborhood Hits	761	Shared Neighborhood Hits	4
SwissProt Accessions	Q9C0K0, Q9H162	Gene names	BCL11B, CTIP2, RIT1
Domain Architecture	No domain graphic available
Description	B-cell lymphoma/leukemia 11B (B-cell CLL/lymphoma 11B) (Radiation- induced tumor suppressor gene 1 protein) (hRit1) (COUP-TF-interacting protein 2).

BC11B_MOUSE
NC score	0.000565 (rank : 19)	θ value	8.99809 (rank : 18)
Query Neighborhood Hits	19	Target Neighborhood Hits	767	Shared Neighborhood Hits	4
SwissProt Accessions	Q99PV8, Q8C2I1, Q99PV6, Q99PV7, Q9JLF8	Gene names	Bcl11b, Ctip2, Rit1
Domain Architecture	No domain graphic available
Description	B-cell lymphoma/leukemia 11B (B-cell CLL/lymphoma 11B) (Radiation- induced tumor suppressor gene 1 protein) (mRit1) (COUP-TF-interacting protein 2).