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Network neighborhood for query Sequence : SIN1_HUMAN

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SIN1_HUMAN
SwissProt Accessions	Q9BPZ7, Q00426	Gene names	MAPKAP1, SIN1
Domain Architecture
Description	Stress-activated map kinase-interacting protein 1 (SAPK-interacting protein 1) (Putative Ras inhibitor JC310).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

SIN1_HUMAN
θ value	0 (rank : 1)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	14	Target Neighborhood Hits	14	Shared Neighborhood Hits	14
SwissProt Accessions	Q9BPZ7, Q00426	Gene names	MAPKAP1, SIN1
Domain Architecture
Description	Stress-activated map kinase-interacting protein 1 (SAPK-interacting protein 1) (Putative Ras inhibitor JC310).

BCA3_MOUSE
θ value	0.365318 (rank : 2)	NC score	0.097920 (rank : 2)
Query Neighborhood Hits	14	Target Neighborhood Hits	6	Shared Neighborhood Hits	2
SwissProt Accessions	Q9JJR5, Q3TR76	Gene names	Bca3
Domain Architecture	No domain graphic available
Description	Proline-rich protein BCA3 (Breast cancer-associated gene 3 protein) (PKA-interacting protein) (AKIP1).

PAK3_MOUSE
θ value	1.06291 (rank : 3)	NC score	0.009357 (rank : 13)
Query Neighborhood Hits	14	Target Neighborhood Hits	874	Shared Neighborhood Hits	3
SwissProt Accessions	Q61036, O88645, Q8K1R5, Q8K1R6	Gene names	Pak3, Pak-3, Pakb, Stk4
Domain Architecture
Description	Serine/threonine-protein kinase PAK 3 (EC 2.7.11.1) (p21-activated kinase 3) (PAK-3) (Beta-PAK) (CDC42/RAC effector kinase PAK-B).

SYCP1_MOUSE
θ value	1.06291 (rank : 4)	NC score	0.017507 (rank : 10)
Query Neighborhood Hits	14	Target Neighborhood Hits	1456	Shared Neighborhood Hits	5
SwissProt Accessions	Q62209, O09205, P70192, Q62329	Gene names	Sycp1, Scp1
Domain Architecture
Description	Synaptonemal complex protein 1 (SCP-1).

CLCA_MOUSE
θ value	2.36792 (rank : 5)	NC score	0.056160 (rank : 3)
Query Neighborhood Hits	14	Target Neighborhood Hits	106	Shared Neighborhood Hits	3
SwissProt Accessions	O08585	Gene names	Clta
Domain Architecture
Description	Clathrin light chain A (Lca).

CLCA_HUMAN
θ value	3.0926 (rank : 6)	NC score	0.053793 (rank : 4)
Query Neighborhood Hits	14	Target Neighborhood Hits	90	Shared Neighborhood Hits	3
SwissProt Accessions	P09496	Gene names	CLTA
Domain Architecture
Description	Clathrin light chain A (Lca).

ADIP_HUMAN
θ value	6.88961 (rank : 7)	NC score	0.027783 (rank : 8)
Query Neighborhood Hits	14	Target Neighborhood Hits	470	Shared Neighborhood Hits	4
SwissProt Accessions	Q9Y2D8, Q6P2P8, Q6ULS1, Q7L168, Q9UIX0	Gene names	SSX2IP, KIAA0923
Domain Architecture	No domain graphic available
Description	Afadin- and alpha-actinin-binding protein (ADIP) (Afadin DIL domain- interacting protein) (SSX2-interacting protein).

ADIP_MOUSE
θ value	6.88961 (rank : 8)	NC score	0.030121 (rank : 6)
Query Neighborhood Hits	14	Target Neighborhood Hits	415	Shared Neighborhood Hits	4
SwissProt Accessions	Q8VC66, Q8BG59, Q8C7X0, Q8K2F7	Gene names	Ssx2ip
Domain Architecture	No domain graphic available
Description	Afadin- and alpha-actinin-binding protein (ADIP) (Afadin DIL domain- interacting protein).

CN044_MOUSE
θ value	6.88961 (rank : 9)	NC score	0.027930 (rank : 7)
Query Neighborhood Hits	14	Target Neighborhood Hits	57	Shared Neighborhood Hits	2
SwissProt Accessions	Q8CB59, Q8BQX8, Q8BSL9, Q8CBZ3	Gene names
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C14orf44 homolog.

PAK3_HUMAN
θ value	6.88961 (rank : 10)	NC score	0.006940 (rank : 14)
Query Neighborhood Hits	14	Target Neighborhood Hits	887	Shared Neighborhood Hits	3
SwissProt Accessions	O75914, Q5JWX1, Q5JWX2, Q7Z2D6, Q7Z2E4, Q7Z3Z8, Q8WWK5, Q8WX23, Q9P0J8	Gene names	PAK3, OPHN3
Domain Architecture
Description	Serine/threonine-protein kinase PAK 3 (EC 2.7.11.1) (p21-activated kinase 3) (PAK-3) (Beta-PAK) (Oligophrenin-3).

RRP44_HUMAN
θ value	6.88961 (rank : 11)	NC score	0.033449 (rank : 5)
Query Neighborhood Hits	14	Target Neighborhood Hits	35	Shared Neighborhood Hits	2
SwissProt Accessions	Q9Y2L1, Q5W0P7, Q5W0P8, Q658Z7, Q7Z481, Q8WWI2, Q9UG36	Gene names	DIS3, KIAA1008, RRP44
Domain Architecture
Description	Exosome complex exonuclease RRP44 (EC 3.1.13.-) (Ribosomal RNA- processing protein 44) (DIS3 protein homolog).

NF2L2_HUMAN
θ value	8.99809 (rank : 12)	NC score	0.016622 (rank : 12)
Query Neighborhood Hits	14	Target Neighborhood Hits	109	Shared Neighborhood Hits	3
SwissProt Accessions	Q16236, Q96F71	Gene names	NFE2L2, NRF2
Domain Architecture
Description	Nuclear factor erythroid 2-related factor 2 (NF-E2-related factor 2) (NFE2-related factor 2) (Nuclear factor, erythroid derived 2, like 2) (HEBP1).

OAS2_HUMAN
θ value	8.99809 (rank : 13)	NC score	0.017137 (rank : 11)
Query Neighborhood Hits	14	Target Neighborhood Hits	14	Shared Neighborhood Hits	2
SwissProt Accessions	P29728, Q86XX8	Gene names	OAS2
Domain Architecture	No domain graphic available
Description	2'-5'-oligoadenylate synthetase 2 (EC 2.7.7.-) ((2-5')oligo(A) synthetase 2) (2-5A synthetase 2) (p69 OAS / p71 OAS) (p69OAS / p71OAS).

ZN533_MOUSE
θ value	8.99809 (rank : 14)	NC score	0.017979 (rank : 9)
Query Neighborhood Hits	14	Target Neighborhood Hits	67	Shared Neighborhood Hits	2
SwissProt Accessions	Q8BXJ8, Q8BWQ7	Gene names	Znf533, Zfp533
Domain Architecture	No domain graphic available
Description	Zinc finger protein 533.

Hits sorted by NC score

SIN1_HUMAN
NC score	0.999962 (rank : 1)	θ value	0 (rank : 1)
Query Neighborhood Hits	14	Target Neighborhood Hits	14	Shared Neighborhood Hits	14
SwissProt Accessions	Q9BPZ7, Q00426	Gene names	MAPKAP1, SIN1
Domain Architecture
Description	Stress-activated map kinase-interacting protein 1 (SAPK-interacting protein 1) (Putative Ras inhibitor JC310).

BCA3_MOUSE
NC score	0.097920 (rank : 2)	θ value	0.365318 (rank : 2)
Query Neighborhood Hits	14	Target Neighborhood Hits	6	Shared Neighborhood Hits	2
SwissProt Accessions	Q9JJR5, Q3TR76	Gene names	Bca3
Domain Architecture	No domain graphic available
Description	Proline-rich protein BCA3 (Breast cancer-associated gene 3 protein) (PKA-interacting protein) (AKIP1).

CLCA_MOUSE
NC score	0.056160 (rank : 3)	θ value	2.36792 (rank : 5)
Query Neighborhood Hits	14	Target Neighborhood Hits	106	Shared Neighborhood Hits	3
SwissProt Accessions	O08585	Gene names	Clta
Domain Architecture
Description	Clathrin light chain A (Lca).

CLCA_HUMAN
NC score	0.053793 (rank : 4)	θ value	3.0926 (rank : 6)
Query Neighborhood Hits	14	Target Neighborhood Hits	90	Shared Neighborhood Hits	3
SwissProt Accessions	P09496	Gene names	CLTA
Domain Architecture
Description	Clathrin light chain A (Lca).

RRP44_HUMAN
NC score	0.033449 (rank : 5)	θ value	6.88961 (rank : 11)
Query Neighborhood Hits	14	Target Neighborhood Hits	35	Shared Neighborhood Hits	2
SwissProt Accessions	Q9Y2L1, Q5W0P7, Q5W0P8, Q658Z7, Q7Z481, Q8WWI2, Q9UG36	Gene names	DIS3, KIAA1008, RRP44
Domain Architecture
Description	Exosome complex exonuclease RRP44 (EC 3.1.13.-) (Ribosomal RNA- processing protein 44) (DIS3 protein homolog).

ADIP_MOUSE
NC score	0.030121 (rank : 6)	θ value	6.88961 (rank : 8)
Query Neighborhood Hits	14	Target Neighborhood Hits	415	Shared Neighborhood Hits	4
SwissProt Accessions	Q8VC66, Q8BG59, Q8C7X0, Q8K2F7	Gene names	Ssx2ip
Domain Architecture	No domain graphic available
Description	Afadin- and alpha-actinin-binding protein (ADIP) (Afadin DIL domain- interacting protein).

CN044_MOUSE
NC score	0.027930 (rank : 7)	θ value	6.88961 (rank : 9)
Query Neighborhood Hits	14	Target Neighborhood Hits	57	Shared Neighborhood Hits	2
SwissProt Accessions	Q8CB59, Q8BQX8, Q8BSL9, Q8CBZ3	Gene names
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C14orf44 homolog.

ADIP_HUMAN
NC score	0.027783 (rank : 8)	θ value	6.88961 (rank : 7)
Query Neighborhood Hits	14	Target Neighborhood Hits	470	Shared Neighborhood Hits	4
SwissProt Accessions	Q9Y2D8, Q6P2P8, Q6ULS1, Q7L168, Q9UIX0	Gene names	SSX2IP, KIAA0923
Domain Architecture	No domain graphic available
Description	Afadin- and alpha-actinin-binding protein (ADIP) (Afadin DIL domain- interacting protein) (SSX2-interacting protein).

ZN533_MOUSE
NC score	0.017979 (rank : 9)	θ value	8.99809 (rank : 14)
Query Neighborhood Hits	14	Target Neighborhood Hits	67	Shared Neighborhood Hits	2
SwissProt Accessions	Q8BXJ8, Q8BWQ7	Gene names	Znf533, Zfp533
Domain Architecture	No domain graphic available
Description	Zinc finger protein 533.

SYCP1_MOUSE
NC score	0.017507 (rank : 10)	θ value	1.06291 (rank : 4)
Query Neighborhood Hits	14	Target Neighborhood Hits	1456	Shared Neighborhood Hits	5
SwissProt Accessions	Q62209, O09205, P70192, Q62329	Gene names	Sycp1, Scp1
Domain Architecture
Description	Synaptonemal complex protein 1 (SCP-1).

OAS2_HUMAN
NC score	0.017137 (rank : 11)	θ value	8.99809 (rank : 13)
Query Neighborhood Hits	14	Target Neighborhood Hits	14	Shared Neighborhood Hits	2
SwissProt Accessions	P29728, Q86XX8	Gene names	OAS2
Domain Architecture	No domain graphic available
Description	2'-5'-oligoadenylate synthetase 2 (EC 2.7.7.-) ((2-5')oligo(A) synthetase 2) (2-5A synthetase 2) (p69 OAS / p71 OAS) (p69OAS / p71OAS).

NF2L2_HUMAN
NC score	0.016622 (rank : 12)	θ value	8.99809 (rank : 12)
Query Neighborhood Hits	14	Target Neighborhood Hits	109	Shared Neighborhood Hits	3
SwissProt Accessions	Q16236, Q96F71	Gene names	NFE2L2, NRF2
Domain Architecture
Description	Nuclear factor erythroid 2-related factor 2 (NF-E2-related factor 2) (NFE2-related factor 2) (Nuclear factor, erythroid derived 2, like 2) (HEBP1).

PAK3_MOUSE
NC score	0.009357 (rank : 13)	θ value	1.06291 (rank : 3)
Query Neighborhood Hits	14	Target Neighborhood Hits	874	Shared Neighborhood Hits	3
SwissProt Accessions	Q61036, O88645, Q8K1R5, Q8K1R6	Gene names	Pak3, Pak-3, Pakb, Stk4
Domain Architecture
Description	Serine/threonine-protein kinase PAK 3 (EC 2.7.11.1) (p21-activated kinase 3) (PAK-3) (Beta-PAK) (CDC42/RAC effector kinase PAK-B).

PAK3_HUMAN
NC score	0.006940 (rank : 14)	θ value	6.88961 (rank : 10)
Query Neighborhood Hits	14	Target Neighborhood Hits	887	Shared Neighborhood Hits	3
SwissProt Accessions	O75914, Q5JWX1, Q5JWX2, Q7Z2D6, Q7Z2E4, Q7Z3Z8, Q8WWK5, Q8WX23, Q9P0J8	Gene names	PAK3, OPHN3
Domain Architecture
Description	Serine/threonine-protein kinase PAK 3 (EC 2.7.11.1) (p21-activated kinase 3) (PAK-3) (Beta-PAK) (Oligophrenin-3).