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Network neighborhood for query Sequence : SECR_HUMAN

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SECR_HUMAN
SwissProt Accessions	P09683	Gene names	SCT
Domain Architecture
Description	Secretin precursor.
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

SECR_HUMAN
θ value	3.2585e-50 (rank : 1)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	15	Target Neighborhood Hits	15	Shared Neighborhood Hits	15
SwissProt Accessions	P09683	Gene names	SCT
Domain Architecture
Description	Secretin precursor.

SECR_MOUSE
θ value	1.74391e-19 (rank : 2)	NC score	0.892793 (rank : 2)
Query Neighborhood Hits	15	Target Neighborhood Hits	13	Shared Neighborhood Hits	11
SwissProt Accessions	Q08535	Gene names	Sct
Domain Architecture
Description	Secretin precursor.

PACA_MOUSE
θ value	0.000121331 (rank : 3)	NC score	0.433745 (rank : 3)
Query Neighborhood Hits	15	Target Neighborhood Hits	11	Shared Neighborhood Hits	10
SwissProt Accessions	O70176	Gene names	Adcyap1, Pacap
Domain Architecture
Description	Pituitary adenylate cyclase-activating polypeptide precursor (PACAP) [Contains: PACAP-related peptide (PRP-48); Pituitary adenylate cyclase-activating polypeptide 27 (PACAP-27) (PACAP27); Pituitary adenylate cyclase-activating polypeptide 38 (PACAP-38) (PACAP38)].

PACA_HUMAN
θ value	0.00665767 (rank : 4)	NC score	0.404541 (rank : 4)
Query Neighborhood Hits	15	Target Neighborhood Hits	10	Shared Neighborhood Hits	9
SwissProt Accessions	P18509	Gene names	ADCYAP1
Domain Architecture
Description	Pituitary adenylate cyclase-activating polypeptide precursor (PACAP) [Contains: PACAP-related peptide (PRP-48); Pituitary adenylate cyclase-activating polypeptide 27 (PACAP-27) (PACAP27); Pituitary adenylate cyclase-activating polypeptide 38 (PACAP-38) (PACAP38)].

VIP_MOUSE
θ value	0.21417 (rank : 5)	NC score	0.312153 (rank : 5)
Query Neighborhood Hits	15	Target Neighborhood Hits	11	Shared Neighborhood Hits	10
SwissProt Accessions	P32648, Q9D2Z7, Q9QUN1	Gene names	Vip
Domain Architecture	No domain graphic available
Description	VIP peptides precursor [Contains: Intestinal peptide PHI-42; Intestinal peptide PHI-27 (Peptide histidine isoleucinamide 27); Vasoactive intestinal peptide (VIP) (Vasoactive intestinal polypeptide)].

SLIB_MOUSE
θ value	0.365318 (rank : 6)	NC score	0.233793 (rank : 7)
Query Neighborhood Hits	15	Target Neighborhood Hits	10	Shared Neighborhood Hits	9
SwissProt Accessions	P16043	Gene names	Ghrh
Domain Architecture
Description	Somatoliberin precursor (Growth hormone-releasing factor) (GRF) (Growth hormone-releasing hormone) (GHRH).

VIP_HUMAN
θ value	0.62314 (rank : 7)	NC score	0.301005 (rank : 6)
Query Neighborhood Hits	15	Target Neighborhood Hits	11	Shared Neighborhood Hits	10
SwissProt Accessions	P01282, Q96QK3	Gene names	VIP
Domain Architecture
Description	VIP peptides precursor [Contains: Intestinal peptide PHV-42; Intestinal peptide PHM-27 (Peptide histidine methioninamide 27); Vasoactive intestinal peptide (VIP) (Vasoactive intestinal polypeptide)].

GLUC_HUMAN
θ value	1.81305 (rank : 8)	NC score	0.156612 (rank : 9)
Query Neighborhood Hits	15	Target Neighborhood Hits	12	Shared Neighborhood Hits	9
SwissProt Accessions	P01275	Gene names	GCG
Domain Architecture
Description	Glucagon precursor [Contains: Glicentin; Glicentin-related polypeptide (GRPP); Oxyntomodulin (OXY) (OXM); Glucagon; Glucagon-like peptide 1 (GLP-1); Glucagon-like peptide 1(7-37) (GLP-1(7-37)); Glucagon-like peptide 1(7-36) (GLP-1(7-36)); Glucagon-like peptide 2 (GLP-2)].

GLUC_MOUSE
θ value	1.81305 (rank : 9)	NC score	0.155651 (rank : 10)
Query Neighborhood Hits	15	Target Neighborhood Hits	11	Shared Neighborhood Hits	9
SwissProt Accessions	P55095, Q3UFE9	Gene names	Gcg
Domain Architecture
Description	Glucagon precursor [Contains: Glicentin; Glicentin-related polypeptide (GRPP); Oxyntomodulin (OXY) (OXM); Glucagon; Glucagon-like peptide 1 (GLP-1); Glucagon-like peptide 1(7-37) (GLP-1(7-37)); Glucagon-like peptide 1(7-36) (GLP-1(7-36)); Glucagon-like peptide 2 (GLP-2)].

NOTC3_MOUSE
θ value	1.81305 (rank : 10)	NC score	0.012052 (rank : 13)
Query Neighborhood Hits	15	Target Neighborhood Hits	975	Shared Neighborhood Hits	3
SwissProt Accessions	Q61982	Gene names	Notch3
Domain Architecture
Description	Neurogenic locus notch homolog protein 3 precursor (Notch 3) [Contains: Notch 3 extracellular truncation; Notch 3 intracellular domain].

SLIB_HUMAN
θ value	4.03905 (rank : 11)	NC score	0.197594 (rank : 8)
Query Neighborhood Hits	15	Target Neighborhood Hits	8	Shared Neighborhood Hits	8
SwissProt Accessions	P01286	Gene names	GHRH, GHRF
Domain Architecture
Description	Somatoliberin precursor (Growth hormone-releasing factor) (GRF) (Growth hormone-releasing hormone) (GHRH) (Somatocrinin) (Somatorelin) (Sermorelin).

WNK1_HUMAN
θ value	6.88961 (rank : 12)	NC score	0.006581 (rank : 15)
Query Neighborhood Hits	15	Target Neighborhood Hits	1158	Shared Neighborhood Hits	3
SwissProt Accessions	Q9H4A3, O15052, Q86WL5, Q8N673, Q9P1S9	Gene names	WNK1, KDP, KIAA0344, PRKWNK1
Domain Architecture
Description	Serine/threonine-protein kinase WNK1 (EC 2.7.11.1) (Protein kinase with no lysine 1) (Protein kinase, lysine-deficient 1) (Kinase deficient protein).

ATS8_HUMAN
θ value	8.99809 (rank : 13)	NC score	0.007876 (rank : 14)
Query Neighborhood Hits	15	Target Neighborhood Hits	145	Shared Neighborhood Hits	3
SwissProt Accessions	Q9UP79, Q9NZS0	Gene names	ADAMTS8, METH2
Domain Architecture
Description	ADAMTS-8 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase with thrombospondin motifs 8) (ADAM-TS 8) (ADAM-TS8) (METH-2) (METH- 8).

DYHC_HUMAN
θ value	8.99809 (rank : 14)	NC score	0.022423 (rank : 12)
Query Neighborhood Hits	15	Target Neighborhood Hits	733	Shared Neighborhood Hits	3
SwissProt Accessions	Q14204, Q6DKQ7, Q8WU28, Q92814, Q9Y4G5	Gene names	DYNC1H1, DNCH1, DNECL, KIAA0325
Domain Architecture	No domain graphic available
Description	Dynein heavy chain, cytosolic (DYHC) (Cytoplasmic dynein heavy chain 1) (DHC1) (Dynein heavy chain 1, cytoplasmic 1).

DYHC_MOUSE
θ value	8.99809 (rank : 15)	NC score	0.022446 (rank : 11)
Query Neighborhood Hits	15	Target Neighborhood Hits	729	Shared Neighborhood Hits	3
SwissProt Accessions	Q9JHU4	Gene names	Dync1h1, Dnch1, Dnchc1
Domain Architecture
Description	Dynein heavy chain, cytosolic (DYHC) (Cytoplasmic dynein heavy chain 1) (DHC1) (Dynein heavy chain 1, cytoplasmic 1).

Hits sorted by NC score

SECR_HUMAN
NC score	0.999962 (rank : 1)	θ value	3.2585e-50 (rank : 1)
Query Neighborhood Hits	15	Target Neighborhood Hits	15	Shared Neighborhood Hits	15
SwissProt Accessions	P09683	Gene names	SCT
Domain Architecture
Description	Secretin precursor.

SECR_MOUSE
NC score	0.892793 (rank : 2)	θ value	1.74391e-19 (rank : 2)
Query Neighborhood Hits	15	Target Neighborhood Hits	13	Shared Neighborhood Hits	11
SwissProt Accessions	Q08535	Gene names	Sct
Domain Architecture
Description	Secretin precursor.

PACA_MOUSE
NC score	0.433745 (rank : 3)	θ value	0.000121331 (rank : 3)
Query Neighborhood Hits	15	Target Neighborhood Hits	11	Shared Neighborhood Hits	10
SwissProt Accessions	O70176	Gene names	Adcyap1, Pacap
Domain Architecture
Description	Pituitary adenylate cyclase-activating polypeptide precursor (PACAP) [Contains: PACAP-related peptide (PRP-48); Pituitary adenylate cyclase-activating polypeptide 27 (PACAP-27) (PACAP27); Pituitary adenylate cyclase-activating polypeptide 38 (PACAP-38) (PACAP38)].

PACA_HUMAN
NC score	0.404541 (rank : 4)	θ value	0.00665767 (rank : 4)
Query Neighborhood Hits	15	Target Neighborhood Hits	10	Shared Neighborhood Hits	9
SwissProt Accessions	P18509	Gene names	ADCYAP1
Domain Architecture
Description	Pituitary adenylate cyclase-activating polypeptide precursor (PACAP) [Contains: PACAP-related peptide (PRP-48); Pituitary adenylate cyclase-activating polypeptide 27 (PACAP-27) (PACAP27); Pituitary adenylate cyclase-activating polypeptide 38 (PACAP-38) (PACAP38)].

VIP_MOUSE
NC score	0.312153 (rank : 5)	θ value	0.21417 (rank : 5)
Query Neighborhood Hits	15	Target Neighborhood Hits	11	Shared Neighborhood Hits	10
SwissProt Accessions	P32648, Q9D2Z7, Q9QUN1	Gene names	Vip
Domain Architecture	No domain graphic available
Description	VIP peptides precursor [Contains: Intestinal peptide PHI-42; Intestinal peptide PHI-27 (Peptide histidine isoleucinamide 27); Vasoactive intestinal peptide (VIP) (Vasoactive intestinal polypeptide)].

VIP_HUMAN
NC score	0.301005 (rank : 6)	θ value	0.62314 (rank : 7)
Query Neighborhood Hits	15	Target Neighborhood Hits	11	Shared Neighborhood Hits	10
SwissProt Accessions	P01282, Q96QK3	Gene names	VIP
Domain Architecture
Description	VIP peptides precursor [Contains: Intestinal peptide PHV-42; Intestinal peptide PHM-27 (Peptide histidine methioninamide 27); Vasoactive intestinal peptide (VIP) (Vasoactive intestinal polypeptide)].

SLIB_MOUSE
NC score	0.233793 (rank : 7)	θ value	0.365318 (rank : 6)
Query Neighborhood Hits	15	Target Neighborhood Hits	10	Shared Neighborhood Hits	9
SwissProt Accessions	P16043	Gene names	Ghrh
Domain Architecture
Description	Somatoliberin precursor (Growth hormone-releasing factor) (GRF) (Growth hormone-releasing hormone) (GHRH).

SLIB_HUMAN
NC score	0.197594 (rank : 8)	θ value	4.03905 (rank : 11)
Query Neighborhood Hits	15	Target Neighborhood Hits	8	Shared Neighborhood Hits	8
SwissProt Accessions	P01286	Gene names	GHRH, GHRF
Domain Architecture
Description	Somatoliberin precursor (Growth hormone-releasing factor) (GRF) (Growth hormone-releasing hormone) (GHRH) (Somatocrinin) (Somatorelin) (Sermorelin).

GLUC_HUMAN
NC score	0.156612 (rank : 9)	θ value	1.81305 (rank : 8)
Query Neighborhood Hits	15	Target Neighborhood Hits	12	Shared Neighborhood Hits	9
SwissProt Accessions	P01275	Gene names	GCG
Domain Architecture
Description	Glucagon precursor [Contains: Glicentin; Glicentin-related polypeptide (GRPP); Oxyntomodulin (OXY) (OXM); Glucagon; Glucagon-like peptide 1 (GLP-1); Glucagon-like peptide 1(7-37) (GLP-1(7-37)); Glucagon-like peptide 1(7-36) (GLP-1(7-36)); Glucagon-like peptide 2 (GLP-2)].

GLUC_MOUSE
NC score	0.155651 (rank : 10)	θ value	1.81305 (rank : 9)
Query Neighborhood Hits	15	Target Neighborhood Hits	11	Shared Neighborhood Hits	9
SwissProt Accessions	P55095, Q3UFE9	Gene names	Gcg
Domain Architecture
Description	Glucagon precursor [Contains: Glicentin; Glicentin-related polypeptide (GRPP); Oxyntomodulin (OXY) (OXM); Glucagon; Glucagon-like peptide 1 (GLP-1); Glucagon-like peptide 1(7-37) (GLP-1(7-37)); Glucagon-like peptide 1(7-36) (GLP-1(7-36)); Glucagon-like peptide 2 (GLP-2)].

DYHC_MOUSE
NC score	0.022446 (rank : 11)	θ value	8.99809 (rank : 15)
Query Neighborhood Hits	15	Target Neighborhood Hits	729	Shared Neighborhood Hits	3
SwissProt Accessions	Q9JHU4	Gene names	Dync1h1, Dnch1, Dnchc1
Domain Architecture
Description	Dynein heavy chain, cytosolic (DYHC) (Cytoplasmic dynein heavy chain 1) (DHC1) (Dynein heavy chain 1, cytoplasmic 1).

DYHC_HUMAN
NC score	0.022423 (rank : 12)	θ value	8.99809 (rank : 14)
Query Neighborhood Hits	15	Target Neighborhood Hits	733	Shared Neighborhood Hits	3
SwissProt Accessions	Q14204, Q6DKQ7, Q8WU28, Q92814, Q9Y4G5	Gene names	DYNC1H1, DNCH1, DNECL, KIAA0325
Domain Architecture	No domain graphic available
Description	Dynein heavy chain, cytosolic (DYHC) (Cytoplasmic dynein heavy chain 1) (DHC1) (Dynein heavy chain 1, cytoplasmic 1).

NOTC3_MOUSE
NC score	0.012052 (rank : 13)	θ value	1.81305 (rank : 10)
Query Neighborhood Hits	15	Target Neighborhood Hits	975	Shared Neighborhood Hits	3
SwissProt Accessions	Q61982	Gene names	Notch3
Domain Architecture
Description	Neurogenic locus notch homolog protein 3 precursor (Notch 3) [Contains: Notch 3 extracellular truncation; Notch 3 intracellular domain].

ATS8_HUMAN
NC score	0.007876 (rank : 14)	θ value	8.99809 (rank : 13)
Query Neighborhood Hits	15	Target Neighborhood Hits	145	Shared Neighborhood Hits	3
SwissProt Accessions	Q9UP79, Q9NZS0	Gene names	ADAMTS8, METH2
Domain Architecture
Description	ADAMTS-8 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase with thrombospondin motifs 8) (ADAM-TS 8) (ADAM-TS8) (METH-2) (METH- 8).

WNK1_HUMAN
NC score	0.006581 (rank : 15)	θ value	6.88961 (rank : 12)
Query Neighborhood Hits	15	Target Neighborhood Hits	1158	Shared Neighborhood Hits	3
SwissProt Accessions	Q9H4A3, O15052, Q86WL5, Q8N673, Q9P1S9	Gene names	WNK1, KDP, KIAA0344, PRKWNK1
Domain Architecture
Description	Serine/threonine-protein kinase WNK1 (EC 2.7.11.1) (Protein kinase with no lysine 1) (Protein kinase, lysine-deficient 1) (Kinase deficient protein).