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Network neighborhood for query Sequence : RHBD3_HUMAN

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RHBD3_HUMAN
SwissProt Accessions	Q9Y3P4, Q6I9X3, Q9UGQ7	Gene names	RHBDD3, C22orf3
Domain Architecture
Description	Rhomboid domain-containing protein 3.
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

RHBD3_HUMAN
θ value	8.63019e-144 (rank : 1)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	15	Target Neighborhood Hits	15	Shared Neighborhood Hits	15
SwissProt Accessions	Q9Y3P4, Q6I9X3, Q9UGQ7	Gene names	RHBDD3, C22orf3
Domain Architecture
Description	Rhomboid domain-containing protein 3.

RHBD3_MOUSE
θ value	1.18001e-100 (rank : 2)	NC score	0.981910 (rank : 2)
Query Neighborhood Hits	15	Target Neighborhood Hits	16	Shared Neighborhood Hits	6
SwissProt Accessions	Q8BP97, Q3U0Y4, Q5SUT5, Q5SUT6, Q5SUT7	Gene names	Rhbdd3
Domain Architecture	No domain graphic available
Description	Rhomboid domain-containing protein 3.

TR100_HUMAN
θ value	0.813845 (rank : 3)	NC score	0.103731 (rank : 3)
Query Neighborhood Hits	15	Target Neighborhood Hits	11	Shared Neighborhood Hits	3
SwissProt Accessions	O75448, Q14143, Q9NNY5	Gene names	THRAP4, ARC100, DRIP100, KIAA0130, TRAP100
Domain Architecture	No domain graphic available
Description	Thyroid hormone receptor-associated protein complex 100 kDa component (Trap100) (Thyroid hormone receptor-associated protein 4) (Vitamin D3 receptor-interacting protein complex component DRIP100) (Activator- recruited cofactor 100 kDa component) (ARC100).

UBL7_HUMAN
θ value	1.38821 (rank : 4)	NC score	0.072467 (rank : 4)
Query Neighborhood Hits	15	Target Neighborhood Hits	41	Shared Neighborhood Hits	3
SwissProt Accessions	Q96S82, Q96I03	Gene names	UBL7, BMSCUBP
Domain Architecture
Description	Ubiquitin-like protein 7 (Ubiquitin-like protein SB132) (Bone marrow stromal cell ubiquitin-like protein) (BMSC-UbP).

UBL7_MOUSE
θ value	1.38821 (rank : 5)	NC score	0.072383 (rank : 5)
Query Neighborhood Hits	15	Target Neighborhood Hits	44	Shared Neighborhood Hits	3
SwissProt Accessions	Q91W67, Q9D7P5	Gene names	Ubl7
Domain Architecture
Description	Ubiquitin-like protein 7.

ATD3A_HUMAN
θ value	1.81305 (rank : 6)	NC score	0.033892 (rank : 6)
Query Neighborhood Hits	15	Target Neighborhood Hits	248	Shared Neighborhood Hits	3
SwissProt Accessions	Q9NVI7, Q8N275, Q96A50	Gene names	ATAD3A
Domain Architecture	No domain graphic available
Description	ATPase family AAA domain-containing protein 3A.

SPEG_HUMAN
θ value	1.81305 (rank : 7)	NC score	0.006864 (rank : 14)
Query Neighborhood Hits	15	Target Neighborhood Hits	1762	Shared Neighborhood Hits	4
SwissProt Accessions	Q15772, Q27J74, Q695L1, Q6FGA6, Q6ZQW1, Q6ZTL8, Q9P2P9	Gene names	SPEG, APEG1, KIAA1297
Domain Architecture
Description	Striated muscle preferentially expressed protein kinase (EC 2.7.11.1) (Aortic preferentially expressed protein 1) (APEG-1).

WHRN_MOUSE
θ value	3.0926 (rank : 8)	NC score	0.017579 (rank : 12)
Query Neighborhood Hits	15	Target Neighborhood Hits	412	Shared Neighborhood Hits	4
SwissProt Accessions	Q80VW5, Q80TC2, Q80VW4	Gene names	Whrn, Kiaa1526
Domain Architecture	No domain graphic available
Description	Whirlin.

STS2_HUMAN
θ value	4.03905 (rank : 9)	NC score	0.025601 (rank : 7)
Query Neighborhood Hits	15	Target Neighborhood Hits	108	Shared Neighborhood Hits	2
SwissProt Accessions	P57075, Q6HA34, Q6HA35, Q6ISI6, Q6ISK3, Q6ISS9	Gene names	UBASH3A, STS2
Domain Architecture
Description	Suppressor of T-cell receptor signaling 2 (STS-2) (Cbl-interacting protein 4) (CLIP4) (T-cell ubiquitin ligand) (TULA).

ATD3B_HUMAN
θ value	6.88961 (rank : 10)	NC score	0.025594 (rank : 8)
Query Neighborhood Hits	15	Target Neighborhood Hits	340	Shared Neighborhood Hits	3
SwissProt Accessions	Q5T9A4, Q6ZRB5, Q9BUK4, Q9ULE7	Gene names	ATAD3B, KIAA1273
Domain Architecture	No domain graphic available
Description	ATPase family AAA domain-containing protein 3B.

EGR4_HUMAN
θ value	6.88961 (rank : 11)	NC score	0.002572 (rank : 15)
Query Neighborhood Hits	15	Target Neighborhood Hits	939	Shared Neighborhood Hits	3
SwissProt Accessions	Q05215	Gene names	EGR4
Domain Architecture
Description	Early growth response protein 4 (EGR-4) (AT133).

HUWE1_HUMAN
θ value	8.99809 (rank : 12)	NC score	0.019644 (rank : 11)
Query Neighborhood Hits	15	Target Neighborhood Hits	443	Shared Neighborhood Hits	5
SwissProt Accessions	Q7Z6Z7, O15029, Q4G2Z2, Q5H961, Q6P4D0, Q8NG67, Q9BUI0, Q9HCJ4, Q9NSL6, Q9P0A9	Gene names	HUWE1, KIAA0312, KIAA1578, UREB1
Domain Architecture	No domain graphic available
Description	HECT, UBA and WWE domain-containing protein 1 (EC 6.3.2.-) (E3 ubiquitin protein ligase URE-B1) (Mcl-1 ubiquitin ligase E3) (Mule) (ARF-binding protein 1) (ARF-BP1).

HUWE1_MOUSE
θ value	8.99809 (rank : 13)	NC score	0.019963 (rank : 10)
Query Neighborhood Hits	15	Target Neighborhood Hits	406	Shared Neighborhood Hits	6
SwissProt Accessions	Q7TMY8, Q4G2Z1, Q5BMM7, Q6NS61, Q8BNJ7, Q8CFH2, Q8VD14, Q921M5, Q9R0P2	Gene names	Huwe1, Kiaa0312, Ureb1
Domain Architecture	No domain graphic available
Description	HECT, UBA and WWE domain-containing protein 1 (EC 6.3.2.-) (E3 ubiquitin protein ligase URE-B1) (E3Histone).

RFX1_HUMAN
θ value	8.99809 (rank : 14)	NC score	0.024967 (rank : 9)
Query Neighborhood Hits	15	Target Neighborhood Hits	256	Shared Neighborhood Hits	5
SwissProt Accessions	P22670	Gene names	RFX1
Domain Architecture
Description	MHC class II regulatory factor RFX1 (RFX) (Enhancer factor C) (EF-C).

SON_HUMAN
θ value	8.99809 (rank : 15)	NC score	0.008377 (rank : 13)
Query Neighborhood Hits	15	Target Neighborhood Hits	1568	Shared Neighborhood Hits	8
SwissProt Accessions	P18583, O14487, O95981, Q14120, Q9H7B1, Q9P070, Q9P072, Q9UKP9, Q9UPY0	Gene names	SON, C21orf50, DBP5, KIAA1019, NREBP
Domain Architecture
Description	SON protein (SON3) (Negative regulatory element-binding protein) (NRE- binding protein) (DBP-5) (Bax antagonist selected in saccharomyces 1) (BASS1).

Hits sorted by NC score

RHBD3_HUMAN
NC score	0.999962 (rank : 1)	θ value	8.63019e-144 (rank : 1)
Query Neighborhood Hits	15	Target Neighborhood Hits	15	Shared Neighborhood Hits	15
SwissProt Accessions	Q9Y3P4, Q6I9X3, Q9UGQ7	Gene names	RHBDD3, C22orf3
Domain Architecture
Description	Rhomboid domain-containing protein 3.

RHBD3_MOUSE
NC score	0.981910 (rank : 2)	θ value	1.18001e-100 (rank : 2)
Query Neighborhood Hits	15	Target Neighborhood Hits	16	Shared Neighborhood Hits	6
SwissProt Accessions	Q8BP97, Q3U0Y4, Q5SUT5, Q5SUT6, Q5SUT7	Gene names	Rhbdd3
Domain Architecture	No domain graphic available
Description	Rhomboid domain-containing protein 3.

TR100_HUMAN
NC score	0.103731 (rank : 3)	θ value	0.813845 (rank : 3)
Query Neighborhood Hits	15	Target Neighborhood Hits	11	Shared Neighborhood Hits	3
SwissProt Accessions	O75448, Q14143, Q9NNY5	Gene names	THRAP4, ARC100, DRIP100, KIAA0130, TRAP100
Domain Architecture	No domain graphic available
Description	Thyroid hormone receptor-associated protein complex 100 kDa component (Trap100) (Thyroid hormone receptor-associated protein 4) (Vitamin D3 receptor-interacting protein complex component DRIP100) (Activator- recruited cofactor 100 kDa component) (ARC100).

UBL7_HUMAN
NC score	0.072467 (rank : 4)	θ value	1.38821 (rank : 4)
Query Neighborhood Hits	15	Target Neighborhood Hits	41	Shared Neighborhood Hits	3
SwissProt Accessions	Q96S82, Q96I03	Gene names	UBL7, BMSCUBP
Domain Architecture
Description	Ubiquitin-like protein 7 (Ubiquitin-like protein SB132) (Bone marrow stromal cell ubiquitin-like protein) (BMSC-UbP).

UBL7_MOUSE
NC score	0.072383 (rank : 5)	θ value	1.38821 (rank : 5)
Query Neighborhood Hits	15	Target Neighborhood Hits	44	Shared Neighborhood Hits	3
SwissProt Accessions	Q91W67, Q9D7P5	Gene names	Ubl7
Domain Architecture
Description	Ubiquitin-like protein 7.

ATD3A_HUMAN
NC score	0.033892 (rank : 6)	θ value	1.81305 (rank : 6)
Query Neighborhood Hits	15	Target Neighborhood Hits	248	Shared Neighborhood Hits	3
SwissProt Accessions	Q9NVI7, Q8N275, Q96A50	Gene names	ATAD3A
Domain Architecture	No domain graphic available
Description	ATPase family AAA domain-containing protein 3A.

STS2_HUMAN
NC score	0.025601 (rank : 7)	θ value	4.03905 (rank : 9)
Query Neighborhood Hits	15	Target Neighborhood Hits	108	Shared Neighborhood Hits	2
SwissProt Accessions	P57075, Q6HA34, Q6HA35, Q6ISI6, Q6ISK3, Q6ISS9	Gene names	UBASH3A, STS2
Domain Architecture
Description	Suppressor of T-cell receptor signaling 2 (STS-2) (Cbl-interacting protein 4) (CLIP4) (T-cell ubiquitin ligand) (TULA).

ATD3B_HUMAN
NC score	0.025594 (rank : 8)	θ value	6.88961 (rank : 10)
Query Neighborhood Hits	15	Target Neighborhood Hits	340	Shared Neighborhood Hits	3
SwissProt Accessions	Q5T9A4, Q6ZRB5, Q9BUK4, Q9ULE7	Gene names	ATAD3B, KIAA1273
Domain Architecture	No domain graphic available
Description	ATPase family AAA domain-containing protein 3B.

RFX1_HUMAN
NC score	0.024967 (rank : 9)	θ value	8.99809 (rank : 14)
Query Neighborhood Hits	15	Target Neighborhood Hits	256	Shared Neighborhood Hits	5
SwissProt Accessions	P22670	Gene names	RFX1
Domain Architecture
Description	MHC class II regulatory factor RFX1 (RFX) (Enhancer factor C) (EF-C).

HUWE1_MOUSE
NC score	0.019963 (rank : 10)	θ value	8.99809 (rank : 13)
Query Neighborhood Hits	15	Target Neighborhood Hits	406	Shared Neighborhood Hits	6
SwissProt Accessions	Q7TMY8, Q4G2Z1, Q5BMM7, Q6NS61, Q8BNJ7, Q8CFH2, Q8VD14, Q921M5, Q9R0P2	Gene names	Huwe1, Kiaa0312, Ureb1
Domain Architecture	No domain graphic available
Description	HECT, UBA and WWE domain-containing protein 1 (EC 6.3.2.-) (E3 ubiquitin protein ligase URE-B1) (E3Histone).

HUWE1_HUMAN
NC score	0.019644 (rank : 11)	θ value	8.99809 (rank : 12)
Query Neighborhood Hits	15	Target Neighborhood Hits	443	Shared Neighborhood Hits	5
SwissProt Accessions	Q7Z6Z7, O15029, Q4G2Z2, Q5H961, Q6P4D0, Q8NG67, Q9BUI0, Q9HCJ4, Q9NSL6, Q9P0A9	Gene names	HUWE1, KIAA0312, KIAA1578, UREB1
Domain Architecture	No domain graphic available
Description	HECT, UBA and WWE domain-containing protein 1 (EC 6.3.2.-) (E3 ubiquitin protein ligase URE-B1) (Mcl-1 ubiquitin ligase E3) (Mule) (ARF-binding protein 1) (ARF-BP1).

WHRN_MOUSE
NC score	0.017579 (rank : 12)	θ value	3.0926 (rank : 8)
Query Neighborhood Hits	15	Target Neighborhood Hits	412	Shared Neighborhood Hits	4
SwissProt Accessions	Q80VW5, Q80TC2, Q80VW4	Gene names	Whrn, Kiaa1526
Domain Architecture	No domain graphic available
Description	Whirlin.

SON_HUMAN
NC score	0.008377 (rank : 13)	θ value	8.99809 (rank : 15)
Query Neighborhood Hits	15	Target Neighborhood Hits	1568	Shared Neighborhood Hits	8
SwissProt Accessions	P18583, O14487, O95981, Q14120, Q9H7B1, Q9P070, Q9P072, Q9UKP9, Q9UPY0	Gene names	SON, C21orf50, DBP5, KIAA1019, NREBP
Domain Architecture
Description	SON protein (SON3) (Negative regulatory element-binding protein) (NRE- binding protein) (DBP-5) (Bax antagonist selected in saccharomyces 1) (BASS1).

SPEG_HUMAN
NC score	0.006864 (rank : 14)	θ value	1.81305 (rank : 7)
Query Neighborhood Hits	15	Target Neighborhood Hits	1762	Shared Neighborhood Hits	4
SwissProt Accessions	Q15772, Q27J74, Q695L1, Q6FGA6, Q6ZQW1, Q6ZTL8, Q9P2P9	Gene names	SPEG, APEG1, KIAA1297
Domain Architecture
Description	Striated muscle preferentially expressed protein kinase (EC 2.7.11.1) (Aortic preferentially expressed protein 1) (APEG-1).

EGR4_HUMAN
NC score	0.002572 (rank : 15)	θ value	6.88961 (rank : 11)
Query Neighborhood Hits	15	Target Neighborhood Hits	939	Shared Neighborhood Hits	3
SwissProt Accessions	Q05215	Gene names	EGR4
Domain Architecture
Description	Early growth response protein 4 (EGR-4) (AT133).