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Network neighborhood for query Sequence : PYRD_HUMAN

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PYRD_HUMAN
SwissProt Accessions	Q02127, Q6P176	Gene names	DHODH
Domain Architecture	No domain graphic available
Description	Dihydroorotate dehydrogenase, mitochondrial precursor (EC 1.3.3.1) (Dihydroorotate oxidase) (DHOdehase).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

PYRD_HUMAN
θ value	0 (rank : 1)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	11	Target Neighborhood Hits	11	Shared Neighborhood Hits	11
SwissProt Accessions	Q02127, Q6P176	Gene names	DHODH
Domain Architecture	No domain graphic available
Description	Dihydroorotate dehydrogenase, mitochondrial precursor (EC 1.3.3.1) (Dihydroorotate oxidase) (DHOdehase).

PYRD_MOUSE
θ value	0 (rank : 2)	NC score	0.996245 (rank : 2)
Query Neighborhood Hits	11	Target Neighborhood Hits	5	Shared Neighborhood Hits	5
SwissProt Accessions	O35435	Gene names	Dhodh
Domain Architecture
Description	Dihydroorotate dehydrogenase, mitochondrial precursor (EC 1.3.3.1) (Dihydroorotate oxidase) (DHOdehase).

DPYD_HUMAN
θ value	6.87365e-08 (rank : 3)	NC score	0.367397 (rank : 3)
Query Neighborhood Hits	11	Target Neighborhood Hits	37	Shared Neighborhood Hits	3
SwissProt Accessions	Q12882, Q16694, Q16761, Q96TH1	Gene names	DPYD
Domain Architecture
Description	Dihydropyrimidine dehydrogenase [NADP+] precursor (EC 1.3.1.2) (DPD) (DHPDHase) (Dihydrouracil dehydrogenase) (Dihydrothymine dehydrogenase).

DYHC_HUMAN
θ value	0.163984 (rank : 4)	NC score	0.055429 (rank : 7)
Query Neighborhood Hits	11	Target Neighborhood Hits	733	Shared Neighborhood Hits	4
SwissProt Accessions	Q14204, Q6DKQ7, Q8WU28, Q92814, Q9Y4G5	Gene names	DYNC1H1, DNCH1, DNECL, KIAA0325
Domain Architecture	No domain graphic available
Description	Dynein heavy chain, cytosolic (DYHC) (Cytoplasmic dynein heavy chain 1) (DHC1) (Dynein heavy chain 1, cytoplasmic 1).

DYHC_MOUSE
θ value	0.163984 (rank : 5)	NC score	0.055479 (rank : 6)
Query Neighborhood Hits	11	Target Neighborhood Hits	729	Shared Neighborhood Hits	4
SwissProt Accessions	Q9JHU4	Gene names	Dync1h1, Dnch1, Dnchc1
Domain Architecture
Description	Dynein heavy chain, cytosolic (DYHC) (Cytoplasmic dynein heavy chain 1) (DHC1) (Dynein heavy chain 1, cytoplasmic 1).

HAOX2_MOUSE
θ value	0.279714 (rank : 6)	NC score	0.092680 (rank : 4)
Query Neighborhood Hits	11	Target Neighborhood Hits	14	Shared Neighborhood Hits	4
SwissProt Accessions	Q9NYQ2, Q9JHS7, Q9JI00	Gene names	Hao2, Hao3, Haox2
Domain Architecture
Description	Hydroxyacid oxidase 2 (EC 1.1.3.15) (HAOX2) ((S)-2-hydroxy-acid oxidase, peroxisomal) (Medium chain alpha-hydroxy acid oxidase) (Medium-chain L-2-hydroxy acid oxidase).

HAOX2_HUMAN
θ value	1.06291 (rank : 7)	NC score	0.084019 (rank : 5)
Query Neighborhood Hits	11	Target Neighborhood Hits	11	Shared Neighborhood Hits	4
SwissProt Accessions	Q9NYQ3, Q9UJS6	Gene names	HAO2, HAOX2
Domain Architecture
Description	Hydroxyacid oxidase 2 (EC 1.1.3.15) (HAOX2) ((S)-2-hydroxy-acid oxidase, peroxisomal) (Long chain alpha-hydroxy acid oxidase) (Long- chain L-2-hydroxy acid oxidase).

CEND1_HUMAN
θ value	4.03905 (rank : 8)	NC score	0.012737 (rank : 9)
Query Neighborhood Hits	11	Target Neighborhood Hits	284	Shared Neighborhood Hits	2
SwissProt Accessions	Q8WZ64, Q4W5D2, Q7Z2L5, Q96L70, Q96P49, Q9Y4E4	Gene names	CENTD1, ARAP2, KIAA0580
Domain Architecture	No domain graphic available
Description	Centaurin-delta 1 (Cnt-d1) (Arf-GAP, Rho-GAP, ankyrin repeat and pleckstrin homology domain-containing protein 2) (PARX protein).

SPRE_HUMAN
θ value	4.03905 (rank : 9)	NC score	0.028898 (rank : 8)
Query Neighborhood Hits	11	Target Neighborhood Hits	32	Shared Neighborhood Hits	2
SwissProt Accessions	P35270	Gene names	SPR
Domain Architecture
Description	Sepiapterin reductase (EC 1.1.1.153) (SPR).

PLAP_HUMAN
θ value	6.88961 (rank : 10)	NC score	0.009116 (rank : 10)
Query Neighborhood Hits	11	Target Neighborhood Hits	266	Shared Neighborhood Hits	2
SwissProt Accessions	Q9Y263, Q53EU5, Q5VY33, Q9NUL8, Q9NVE9, Q9UF53, Q9Y5L1	Gene names	PLAA, PLAP
Domain Architecture
Description	Phospholipase A-2-activating protein (PLAP) (PLA2P).

NAF1_HUMAN
θ value	8.99809 (rank : 11)	NC score	0.007040 (rank : 11)
Query Neighborhood Hits	11	Target Neighborhood Hits	937	Shared Neighborhood Hits	4
SwissProt Accessions	Q15025, O76008, Q96EL9, Q99833, Q9H1J3	Gene names	TNIP1, KIAA0113, NAF1
Domain Architecture
Description	Nef-associated factor 1 (Naf1) (TNFAIP3-interacting protein 1) (HIV-1 Nef-interacting protein) (Virion-associated nuclear shuttling protein) (VAN) (hVAN) (Nip40-1).

Hits sorted by NC score

PYRD_HUMAN
NC score	0.999962 (rank : 1)	θ value	0 (rank : 1)
Query Neighborhood Hits	11	Target Neighborhood Hits	11	Shared Neighborhood Hits	11
SwissProt Accessions	Q02127, Q6P176	Gene names	DHODH
Domain Architecture	No domain graphic available
Description	Dihydroorotate dehydrogenase, mitochondrial precursor (EC 1.3.3.1) (Dihydroorotate oxidase) (DHOdehase).

PYRD_MOUSE
NC score	0.996245 (rank : 2)	θ value	0 (rank : 2)
Query Neighborhood Hits	11	Target Neighborhood Hits	5	Shared Neighborhood Hits	5
SwissProt Accessions	O35435	Gene names	Dhodh
Domain Architecture
Description	Dihydroorotate dehydrogenase, mitochondrial precursor (EC 1.3.3.1) (Dihydroorotate oxidase) (DHOdehase).

DPYD_HUMAN
NC score	0.367397 (rank : 3)	θ value	6.87365e-08 (rank : 3)
Query Neighborhood Hits	11	Target Neighborhood Hits	37	Shared Neighborhood Hits	3
SwissProt Accessions	Q12882, Q16694, Q16761, Q96TH1	Gene names	DPYD
Domain Architecture
Description	Dihydropyrimidine dehydrogenase [NADP+] precursor (EC 1.3.1.2) (DPD) (DHPDHase) (Dihydrouracil dehydrogenase) (Dihydrothymine dehydrogenase).

HAOX2_MOUSE
NC score	0.092680 (rank : 4)	θ value	0.279714 (rank : 6)
Query Neighborhood Hits	11	Target Neighborhood Hits	14	Shared Neighborhood Hits	4
SwissProt Accessions	Q9NYQ2, Q9JHS7, Q9JI00	Gene names	Hao2, Hao3, Haox2
Domain Architecture
Description	Hydroxyacid oxidase 2 (EC 1.1.3.15) (HAOX2) ((S)-2-hydroxy-acid oxidase, peroxisomal) (Medium chain alpha-hydroxy acid oxidase) (Medium-chain L-2-hydroxy acid oxidase).

HAOX2_HUMAN
NC score	0.084019 (rank : 5)	θ value	1.06291 (rank : 7)
Query Neighborhood Hits	11	Target Neighborhood Hits	11	Shared Neighborhood Hits	4
SwissProt Accessions	Q9NYQ3, Q9UJS6	Gene names	HAO2, HAOX2
Domain Architecture
Description	Hydroxyacid oxidase 2 (EC 1.1.3.15) (HAOX2) ((S)-2-hydroxy-acid oxidase, peroxisomal) (Long chain alpha-hydroxy acid oxidase) (Long- chain L-2-hydroxy acid oxidase).

DYHC_MOUSE
NC score	0.055479 (rank : 6)	θ value	0.163984 (rank : 5)
Query Neighborhood Hits	11	Target Neighborhood Hits	729	Shared Neighborhood Hits	4
SwissProt Accessions	Q9JHU4	Gene names	Dync1h1, Dnch1, Dnchc1
Domain Architecture
Description	Dynein heavy chain, cytosolic (DYHC) (Cytoplasmic dynein heavy chain 1) (DHC1) (Dynein heavy chain 1, cytoplasmic 1).

DYHC_HUMAN
NC score	0.055429 (rank : 7)	θ value	0.163984 (rank : 4)
Query Neighborhood Hits	11	Target Neighborhood Hits	733	Shared Neighborhood Hits	4
SwissProt Accessions	Q14204, Q6DKQ7, Q8WU28, Q92814, Q9Y4G5	Gene names	DYNC1H1, DNCH1, DNECL, KIAA0325
Domain Architecture	No domain graphic available
Description	Dynein heavy chain, cytosolic (DYHC) (Cytoplasmic dynein heavy chain 1) (DHC1) (Dynein heavy chain 1, cytoplasmic 1).

SPRE_HUMAN
NC score	0.028898 (rank : 8)	θ value	4.03905 (rank : 9)
Query Neighborhood Hits	11	Target Neighborhood Hits	32	Shared Neighborhood Hits	2
SwissProt Accessions	P35270	Gene names	SPR
Domain Architecture
Description	Sepiapterin reductase (EC 1.1.1.153) (SPR).

CEND1_HUMAN
NC score	0.012737 (rank : 9)	θ value	4.03905 (rank : 8)
Query Neighborhood Hits	11	Target Neighborhood Hits	284	Shared Neighborhood Hits	2
SwissProt Accessions	Q8WZ64, Q4W5D2, Q7Z2L5, Q96L70, Q96P49, Q9Y4E4	Gene names	CENTD1, ARAP2, KIAA0580
Domain Architecture	No domain graphic available
Description	Centaurin-delta 1 (Cnt-d1) (Arf-GAP, Rho-GAP, ankyrin repeat and pleckstrin homology domain-containing protein 2) (PARX protein).

PLAP_HUMAN
NC score	0.009116 (rank : 10)	θ value	6.88961 (rank : 10)
Query Neighborhood Hits	11	Target Neighborhood Hits	266	Shared Neighborhood Hits	2
SwissProt Accessions	Q9Y263, Q53EU5, Q5VY33, Q9NUL8, Q9NVE9, Q9UF53, Q9Y5L1	Gene names	PLAA, PLAP
Domain Architecture
Description	Phospholipase A-2-activating protein (PLAP) (PLA2P).

NAF1_HUMAN
NC score	0.007040 (rank : 11)	θ value	8.99809 (rank : 11)
Query Neighborhood Hits	11	Target Neighborhood Hits	937	Shared Neighborhood Hits	4
SwissProt Accessions	Q15025, O76008, Q96EL9, Q99833, Q9H1J3	Gene names	TNIP1, KIAA0113, NAF1
Domain Architecture
Description	Nef-associated factor 1 (Naf1) (TNFAIP3-interacting protein 1) (HIV-1 Nef-interacting protein) (Virion-associated nuclear shuttling protein) (VAN) (hVAN) (Nip40-1).