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Network neighborhood for query Sequence : PYR5_HUMAN

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PYR5_HUMAN
SwissProt Accessions	P11172, O00758, O00759, O00760, Q16862, Q9H3Q2, Q9UG49	Gene names	UMPS
Domain Architecture
Description	Uridine 5'-monophosphate synthase (UMP synthase) [Includes: Orotate phosphoribosyltransferase (EC 2.4.2.10) (OPRTase); Orotidine 5'- phosphate decarboxylase (EC 4.1.1.23) (OMPdecase)].
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

PYR5_HUMAN
θ value	0 (rank : 1)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	8	Target Neighborhood Hits	8	Shared Neighborhood Hits	8
SwissProt Accessions	P11172, O00758, O00759, O00760, Q16862, Q9H3Q2, Q9UG49	Gene names	UMPS
Domain Architecture
Description	Uridine 5'-monophosphate synthase (UMP synthase) [Includes: Orotate phosphoribosyltransferase (EC 2.4.2.10) (OPRTase); Orotidine 5'- phosphate decarboxylase (EC 4.1.1.23) (OMPdecase)].

PYR5_MOUSE
θ value	0 (rank : 2)	NC score	0.997319 (rank : 2)
Query Neighborhood Hits	8	Target Neighborhood Hits	8	Shared Neighborhood Hits	3
SwissProt Accessions	P13439, Q99L26	Gene names	Umps
Domain Architecture
Description	Uridine 5'-monophosphate synthase (UMP synthase) [Includes: Orotate phosphoribosyltransferase (EC 2.4.2.10) (OPRTase); Orotidine 5'- phosphate decarboxylase (EC 4.1.1.23) (OMPdecase)].

CF182_MOUSE
θ value	3.0926 (rank : 3)	NC score	0.018254 (rank : 5)
Query Neighborhood Hits	8	Target Neighborhood Hits	551	Shared Neighborhood Hits	4
SwissProt Accessions	Q8VDS7, Q9CZE0, Q9D5A1	Gene names
Domain Architecture	No domain graphic available
Description	Protein C6orf182 homolog.

MCPH1_HUMAN
θ value	3.0926 (rank : 4)	NC score	0.029887 (rank : 4)
Query Neighborhood Hits	8	Target Neighborhood Hits	85	Shared Neighborhood Hits	3
SwissProt Accessions	Q8NEM0, Q66GU1, Q9H9C7	Gene names	MCPH1
Domain Architecture
Description	Microcephalin.

NCOA5_HUMAN
θ value	4.03905 (rank : 5)	NC score	0.041954 (rank : 3)
Query Neighborhood Hits	8	Target Neighborhood Hits	99	Shared Neighborhood Hits	3
SwissProt Accessions	Q9HCD5, Q6HA99, Q9H1F2, Q9H2T2, Q9H4Y9	Gene names	NCOA5, KIAA1637
Domain Architecture	No domain graphic available
Description	Nuclear receptor coactivator 5 (NCoA-5) (Coactivator independent of AF-2) (CIA).

STYX_MOUSE
θ value	4.03905 (rank : 6)	NC score	0.015612 (rank : 6)
Query Neighborhood Hits	8	Target Neighborhood Hits	62	Shared Neighborhood Hits	2
SwissProt Accessions	Q60969, Q3TMA3, Q60970, Q9DCF8	Gene names	Styx
Domain Architecture
Description	Serine/threonine/tyrosine-interacting protein (Protein tyrosine phosphatase-like protein) (Phosphoserine/threonine/tyrosine interaction protein).

MSHR_HUMAN
θ value	8.99809 (rank : 7)	NC score	0.003440 (rank : 8)
Query Neighborhood Hits	8	Target Neighborhood Hits	773	Shared Neighborhood Hits	2
SwissProt Accessions	Q01726, Q8WWX6, Q8WWX7, Q96I33, Q96RU4, Q9UBF7, Q9UN58, Q9UN59, Q9UN60, Q9UN61, Q9UN62	Gene names	MC1R, MSHR
Domain Architecture
Description	Melanocyte-stimulating hormone receptor (MSH-R) (Melanotropin receptor) (Melanocortin receptor 1) (MC1-R).

RUFY1_MOUSE
θ value	8.99809 (rank : 8)	NC score	0.005394 (rank : 7)
Query Neighborhood Hits	8	Target Neighborhood Hits	765	Shared Neighborhood Hits	3
SwissProt Accessions	Q8BIJ7, Q8BKQ4, Q8BL21, Q9EPM6	Gene names	Rufy1, Rabip4
Domain Architecture	No domain graphic available
Description	RUN and FYVE domain-containing protein 1 (Rab4-interacting protein).

Hits sorted by NC score

PYR5_HUMAN
NC score	0.999962 (rank : 1)	θ value	0 (rank : 1)
Query Neighborhood Hits	8	Target Neighborhood Hits	8	Shared Neighborhood Hits	8
SwissProt Accessions	P11172, O00758, O00759, O00760, Q16862, Q9H3Q2, Q9UG49	Gene names	UMPS
Domain Architecture
Description	Uridine 5'-monophosphate synthase (UMP synthase) [Includes: Orotate phosphoribosyltransferase (EC 2.4.2.10) (OPRTase); Orotidine 5'- phosphate decarboxylase (EC 4.1.1.23) (OMPdecase)].

PYR5_MOUSE
NC score	0.997319 (rank : 2)	θ value	0 (rank : 2)
Query Neighborhood Hits	8	Target Neighborhood Hits	8	Shared Neighborhood Hits	3
SwissProt Accessions	P13439, Q99L26	Gene names	Umps
Domain Architecture
Description	Uridine 5'-monophosphate synthase (UMP synthase) [Includes: Orotate phosphoribosyltransferase (EC 2.4.2.10) (OPRTase); Orotidine 5'- phosphate decarboxylase (EC 4.1.1.23) (OMPdecase)].

NCOA5_HUMAN
NC score	0.041954 (rank : 3)	θ value	4.03905 (rank : 5)
Query Neighborhood Hits	8	Target Neighborhood Hits	99	Shared Neighborhood Hits	3
SwissProt Accessions	Q9HCD5, Q6HA99, Q9H1F2, Q9H2T2, Q9H4Y9	Gene names	NCOA5, KIAA1637
Domain Architecture	No domain graphic available
Description	Nuclear receptor coactivator 5 (NCoA-5) (Coactivator independent of AF-2) (CIA).

MCPH1_HUMAN
NC score	0.029887 (rank : 4)	θ value	3.0926 (rank : 4)
Query Neighborhood Hits	8	Target Neighborhood Hits	85	Shared Neighborhood Hits	3
SwissProt Accessions	Q8NEM0, Q66GU1, Q9H9C7	Gene names	MCPH1
Domain Architecture
Description	Microcephalin.

CF182_MOUSE
NC score	0.018254 (rank : 5)	θ value	3.0926 (rank : 3)
Query Neighborhood Hits	8	Target Neighborhood Hits	551	Shared Neighborhood Hits	4
SwissProt Accessions	Q8VDS7, Q9CZE0, Q9D5A1	Gene names
Domain Architecture	No domain graphic available
Description	Protein C6orf182 homolog.

STYX_MOUSE
NC score	0.015612 (rank : 6)	θ value	4.03905 (rank : 6)
Query Neighborhood Hits	8	Target Neighborhood Hits	62	Shared Neighborhood Hits	2
SwissProt Accessions	Q60969, Q3TMA3, Q60970, Q9DCF8	Gene names	Styx
Domain Architecture
Description	Serine/threonine/tyrosine-interacting protein (Protein tyrosine phosphatase-like protein) (Phosphoserine/threonine/tyrosine interaction protein).

RUFY1_MOUSE
NC score	0.005394 (rank : 7)	θ value	8.99809 (rank : 8)
Query Neighborhood Hits	8	Target Neighborhood Hits	765	Shared Neighborhood Hits	3
SwissProt Accessions	Q8BIJ7, Q8BKQ4, Q8BL21, Q9EPM6	Gene names	Rufy1, Rabip4
Domain Architecture	No domain graphic available
Description	RUN and FYVE domain-containing protein 1 (Rab4-interacting protein).

MSHR_HUMAN
NC score	0.003440 (rank : 8)	θ value	8.99809 (rank : 7)
Query Neighborhood Hits	8	Target Neighborhood Hits	773	Shared Neighborhood Hits	2
SwissProt Accessions	Q01726, Q8WWX6, Q8WWX7, Q96I33, Q96RU4, Q9UBF7, Q9UN58, Q9UN59, Q9UN60, Q9UN61, Q9UN62	Gene names	MC1R, MSHR
Domain Architecture
Description	Melanocyte-stimulating hormone receptor (MSH-R) (Melanotropin receptor) (Melanocortin receptor 1) (MC1-R).