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Network neighborhood for query Sequence : PSMD6_HUMAN

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PSMD6_HUMAN
SwissProt Accessions	Q15008	Gene names	PSMD6, KIAA0107, PFAAP4
Domain Architecture
Description	26S proteasome non-ATPase regulatory subunit 6 (26S proteasome regulatory subunit S10) (p42A) (Proteasome regulatory particle subunit p44S10) (Phosphonoformate immuno-associated protein 4) (Breast cancer- associated protein SGA-113M).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

PSMD6_HUMAN
θ value	0 (rank : 1)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	18	Target Neighborhood Hits	18	Shared Neighborhood Hits	18
SwissProt Accessions	Q15008	Gene names	PSMD6, KIAA0107, PFAAP4
Domain Architecture
Description	26S proteasome non-ATPase regulatory subunit 6 (26S proteasome regulatory subunit S10) (p42A) (Proteasome regulatory particle subunit p44S10) (Phosphonoformate immuno-associated protein 4) (Breast cancer- associated protein SGA-113M).

PSMD6_MOUSE
θ value	0 (rank : 2)	NC score	0.998548 (rank : 2)
Query Neighborhood Hits	18	Target Neighborhood Hits	20	Shared Neighborhood Hits	15
SwissProt Accessions	Q99JI4, Q9CWZ1	Gene names	Psmd6
Domain Architecture
Description	26S proteasome non-ATPase regulatory subunit 6 (26S proteasome regulatory subunit S10) (p42A).

CSN1_MOUSE
θ value	8.65492e-19 (rank : 3)	NC score	0.623493 (rank : 3)
Query Neighborhood Hits	18	Target Neighborhood Hits	16	Shared Neighborhood Hits	6
SwissProt Accessions	Q99LD4, Q8C2J7	Gene names	Gps1, Cops1, Csn1
Domain Architecture
Description	COP9 signalosome complex subunit 1 (Signalosome subunit 1) (SGN1) (JAB1-containing signalosome subunit 1) (G protein pathway suppressor 1) (Protein GPS1).

CSN1_HUMAN
θ value	9.56915e-18 (rank : 4)	NC score	0.617498 (rank : 4)
Query Neighborhood Hits	18	Target Neighborhood Hits	18	Shared Neighborhood Hits	6
SwissProt Accessions	Q13098, Q8NA10, Q9BWL1	Gene names	GPS1, COPS1, CSN1
Domain Architecture
Description	COP9 signalosome complex subunit 1 (Signalosome subunit 1) (SGN1) (JAB1-containing signalosome subunit 1) (G protein pathway suppressor 1) (Protein GPS1) (Protein MFH).

REST_HUMAN
θ value	0.365318 (rank : 5)	NC score	0.024055 (rank : 13)
Query Neighborhood Hits	18	Target Neighborhood Hits	1605	Shared Neighborhood Hits	9
SwissProt Accessions	P30622	Gene names	RSN, CYLN1
Domain Architecture
Description	Restin (Cytoplasmic linker protein 170 alpha-2) (CLIP-170) (Reed- Sternberg intermediate filament-associated protein) (Cytoplasmic linker protein 1).

AMER1_HUMAN
θ value	0.47712 (rank : 6)	NC score	0.110226 (rank : 8)
Query Neighborhood Hits	18	Target Neighborhood Hits	8	Shared Neighborhood Hits	4
SwissProt Accessions	Q9Y4X0, Q6P9D8, Q8WX22, Q9UIQ8	Gene names	AMMECR1
Domain Architecture
Description	AMME syndrome candidate gene 1 protein.

AMER1_MOUSE
θ value	0.47712 (rank : 7)	NC score	0.111177 (rank : 7)
Query Neighborhood Hits	18	Target Neighborhood Hits	9	Shared Neighborhood Hits	4
SwissProt Accessions	Q9JHT5	Gene names	Ammecr1
Domain Architecture
Description	AMME syndrome candidate gene 1 protein homolog.

CSN2_HUMAN
θ value	0.62314 (rank : 8)	NC score	0.136520 (rank : 5)
Query Neighborhood Hits	18	Target Neighborhood Hits	34	Shared Neighborhood Hits	9
SwissProt Accessions	P61201, O88950, Q15647, Q6FGP4, Q9BY54, Q9R249, Q9UNI2, Q9UNQ5	Gene names	COPS2, CSN2, TRIP15
Domain Architecture
Description	COP9 signalosome complex subunit 2 (Signalosome subunit 2) (SGN2) (JAB1-containing signalosome subunit 2) (Thyroid receptor-interacting protein 15) (Alien homolog).

CSN2_MOUSE
θ value	0.62314 (rank : 9)	NC score	0.136520 (rank : 6)
Query Neighborhood Hits	18	Target Neighborhood Hits	34	Shared Neighborhood Hits	9
SwissProt Accessions	P61202, O88950, Q15647, Q3V1W6, Q8R5B0, Q9CWU1, Q9R249, Q9UNQ5	Gene names	Cops2, Csn2, Trip15
Domain Architecture
Description	COP9 signalosome complex subunit 2 (Signalosome subunit 2) (SGN2) (JAB1-containing signalosome subunit 2) (Thyroid receptor-interacting protein 15) (Alien homolog).

PSD12_HUMAN
θ value	1.38821 (rank : 10)	NC score	0.082868 (rank : 9)
Query Neighborhood Hits	18	Target Neighborhood Hits	70	Shared Neighborhood Hits	6
SwissProt Accessions	O00232, Q53HA2, Q6P053	Gene names	PSMD12
Domain Architecture
Description	26S proteasome non-ATPase regulatory subunit 12 (26S proteasome regulatory subunit p55).

PSD12_MOUSE
θ value	1.81305 (rank : 11)	NC score	0.079542 (rank : 10)
Query Neighborhood Hits	18	Target Neighborhood Hits	69	Shared Neighborhood Hits	7
SwissProt Accessions	Q9D8W5, Q9CYB3	Gene names	Psmd12
Domain Architecture
Description	26S proteasome non-ATPase regulatory subunit 12 (26S proteasome regulatory subunit p55).

MACF1_MOUSE
θ value	2.36792 (rank : 12)	NC score	0.020929 (rank : 16)
Query Neighborhood Hits	18	Target Neighborhood Hits	1313	Shared Neighborhood Hits	9
SwissProt Accessions	Q9QXZ0, P97394, P97395, P97396	Gene names	Macf1, Acf7, Aclp7, Macf
Domain Architecture
Description	Microtubule-actin cross-linking factor 1 (Actin cross-linking family 7).

REST_MOUSE
θ value	2.36792 (rank : 13)	NC score	0.021637 (rank : 14)
Query Neighborhood Hits	18	Target Neighborhood Hits	1506	Shared Neighborhood Hits	10
SwissProt Accessions	Q922J3, Q571L7	Gene names	Rsn, Kiaa4046
Domain Architecture	No domain graphic available
Description	Restin.

MACF4_HUMAN
θ value	5.27518 (rank : 14)	NC score	0.021143 (rank : 15)
Query Neighborhood Hits	18	Target Neighborhood Hits	1321	Shared Neighborhood Hits	9
SwissProt Accessions	Q96PK2, Q8WXY1	Gene names	MACF1, ABP620, ACF7, KIAA0465, KIAA1251
Domain Architecture
Description	Microtubule-actin cross-linking factor 1, isoform 4.

UACA_MOUSE
θ value	5.27518 (rank : 15)	NC score	0.010461 (rank : 18)
Query Neighborhood Hits	18	Target Neighborhood Hits	1620	Shared Neighborhood Hits	8
SwissProt Accessions	Q8CGB3, Q69ZG3, Q7TN77, Q8BJC8	Gene names	Uaca, Kiaa1561
Domain Architecture	No domain graphic available
Description	Uveal autoantigen with coiled-coil domains and ankyrin repeats protein (Nucling) (Nuclear membrane-binding protein).

AT11A_HUMAN
θ value	6.88961 (rank : 16)	NC score	0.006711 (rank : 20)
Query Neighborhood Hits	18	Target Neighborhood Hits	84	Shared Neighborhood Hits	2
SwissProt Accessions	P98196, Q5VXT2	Gene names	ATP11A, ATPIH, ATPIS, KIAA1021
Domain Architecture	No domain graphic available
Description	Probable phospholipid-transporting ATPase IH (EC 3.6.3.1) (ATPase class I type 11A) (ATPase IS).

APXL_HUMAN
θ value	8.99809 (rank : 17)	NC score	0.012715 (rank : 17)
Query Neighborhood Hits	18	Target Neighborhood Hits	553	Shared Neighborhood Hits	4
SwissProt Accessions	Q13796	Gene names	APXL
Domain Architecture
Description	Apical-like protein (Protein APXL).

MYH14_MOUSE
θ value	8.99809 (rank : 18)	NC score	0.006912 (rank : 19)
Query Neighborhood Hits	18	Target Neighborhood Hits	1225	Shared Neighborhood Hits	7
SwissProt Accessions	Q6URW6, Q80V64, Q80ZE6	Gene names	Myh14
Domain Architecture	No domain graphic available
Description	Myosin-14 (Myosin heavy chain, nonmuscle IIc) (Nonmuscle myosin heavy chain IIc) (NMHC II-C).

PSD11_HUMAN
θ value	θ > 10 (rank : 19)	NC score	0.051172 (rank : 12)
Query Neighborhood Hits	18	Target Neighborhood Hits	22	Shared Neighborhood Hits	4
SwissProt Accessions	O00231, O00495	Gene names	PSMD11
Domain Architecture
Description	26S proteasome non-ATPase regulatory subunit 11 (26S proteasome regulatory subunit S9) (26S proteasome regulatory subunit p44.5).

PSD11_MOUSE
θ value	θ > 10 (rank : 20)	NC score	0.051249 (rank : 11)
Query Neighborhood Hits	18	Target Neighborhood Hits	22	Shared Neighborhood Hits	4
SwissProt Accessions	Q8BG32	Gene names	Psmd11
Domain Architecture	No domain graphic available
Description	26S proteasome non-ATPase regulatory subunit 11 (26S proteasome regulatory subunit S9) (26S proteasome regulatory subunit p44.5).

Hits sorted by NC score

PSMD6_HUMAN
NC score	0.999962 (rank : 1)	θ value	0 (rank : 1)
Query Neighborhood Hits	18	Target Neighborhood Hits	18	Shared Neighborhood Hits	18
SwissProt Accessions	Q15008	Gene names	PSMD6, KIAA0107, PFAAP4
Domain Architecture
Description	26S proteasome non-ATPase regulatory subunit 6 (26S proteasome regulatory subunit S10) (p42A) (Proteasome regulatory particle subunit p44S10) (Phosphonoformate immuno-associated protein 4) (Breast cancer- associated protein SGA-113M).

PSMD6_MOUSE
NC score	0.998548 (rank : 2)	θ value	0 (rank : 2)
Query Neighborhood Hits	18	Target Neighborhood Hits	20	Shared Neighborhood Hits	15
SwissProt Accessions	Q99JI4, Q9CWZ1	Gene names	Psmd6
Domain Architecture
Description	26S proteasome non-ATPase regulatory subunit 6 (26S proteasome regulatory subunit S10) (p42A).

CSN1_MOUSE
NC score	0.623493 (rank : 3)	θ value	8.65492e-19 (rank : 3)
Query Neighborhood Hits	18	Target Neighborhood Hits	16	Shared Neighborhood Hits	6
SwissProt Accessions	Q99LD4, Q8C2J7	Gene names	Gps1, Cops1, Csn1
Domain Architecture
Description	COP9 signalosome complex subunit 1 (Signalosome subunit 1) (SGN1) (JAB1-containing signalosome subunit 1) (G protein pathway suppressor 1) (Protein GPS1).

CSN1_HUMAN
NC score	0.617498 (rank : 4)	θ value	9.56915e-18 (rank : 4)
Query Neighborhood Hits	18	Target Neighborhood Hits	18	Shared Neighborhood Hits	6
SwissProt Accessions	Q13098, Q8NA10, Q9BWL1	Gene names	GPS1, COPS1, CSN1
Domain Architecture
Description	COP9 signalosome complex subunit 1 (Signalosome subunit 1) (SGN1) (JAB1-containing signalosome subunit 1) (G protein pathway suppressor 1) (Protein GPS1) (Protein MFH).

CSN2_HUMAN
NC score	0.136520 (rank : 5)	θ value	0.62314 (rank : 8)
Query Neighborhood Hits	18	Target Neighborhood Hits	34	Shared Neighborhood Hits	9
SwissProt Accessions	P61201, O88950, Q15647, Q6FGP4, Q9BY54, Q9R249, Q9UNI2, Q9UNQ5	Gene names	COPS2, CSN2, TRIP15
Domain Architecture
Description	COP9 signalosome complex subunit 2 (Signalosome subunit 2) (SGN2) (JAB1-containing signalosome subunit 2) (Thyroid receptor-interacting protein 15) (Alien homolog).

CSN2_MOUSE
NC score	0.136520 (rank : 6)	θ value	0.62314 (rank : 9)
Query Neighborhood Hits	18	Target Neighborhood Hits	34	Shared Neighborhood Hits	9
SwissProt Accessions	P61202, O88950, Q15647, Q3V1W6, Q8R5B0, Q9CWU1, Q9R249, Q9UNQ5	Gene names	Cops2, Csn2, Trip15
Domain Architecture
Description	COP9 signalosome complex subunit 2 (Signalosome subunit 2) (SGN2) (JAB1-containing signalosome subunit 2) (Thyroid receptor-interacting protein 15) (Alien homolog).

AMER1_MOUSE
NC score	0.111177 (rank : 7)	θ value	0.47712 (rank : 7)
Query Neighborhood Hits	18	Target Neighborhood Hits	9	Shared Neighborhood Hits	4
SwissProt Accessions	Q9JHT5	Gene names	Ammecr1
Domain Architecture
Description	AMME syndrome candidate gene 1 protein homolog.

AMER1_HUMAN
NC score	0.110226 (rank : 8)	θ value	0.47712 (rank : 6)
Query Neighborhood Hits	18	Target Neighborhood Hits	8	Shared Neighborhood Hits	4
SwissProt Accessions	Q9Y4X0, Q6P9D8, Q8WX22, Q9UIQ8	Gene names	AMMECR1
Domain Architecture
Description	AMME syndrome candidate gene 1 protein.

PSD12_HUMAN
NC score	0.082868 (rank : 9)	θ value	1.38821 (rank : 10)
Query Neighborhood Hits	18	Target Neighborhood Hits	70	Shared Neighborhood Hits	6
SwissProt Accessions	O00232, Q53HA2, Q6P053	Gene names	PSMD12
Domain Architecture
Description	26S proteasome non-ATPase regulatory subunit 12 (26S proteasome regulatory subunit p55).

PSD12_MOUSE
NC score	0.079542 (rank : 10)	θ value	1.81305 (rank : 11)
Query Neighborhood Hits	18	Target Neighborhood Hits	69	Shared Neighborhood Hits	7
SwissProt Accessions	Q9D8W5, Q9CYB3	Gene names	Psmd12
Domain Architecture
Description	26S proteasome non-ATPase regulatory subunit 12 (26S proteasome regulatory subunit p55).

PSD11_MOUSE
NC score	0.051249 (rank : 11)	θ value	θ > 10 (rank : 20)
Query Neighborhood Hits	18	Target Neighborhood Hits	22	Shared Neighborhood Hits	4
SwissProt Accessions	Q8BG32	Gene names	Psmd11
Domain Architecture	No domain graphic available
Description	26S proteasome non-ATPase regulatory subunit 11 (26S proteasome regulatory subunit S9) (26S proteasome regulatory subunit p44.5).

PSD11_HUMAN
NC score	0.051172 (rank : 12)	θ value	θ > 10 (rank : 19)
Query Neighborhood Hits	18	Target Neighborhood Hits	22	Shared Neighborhood Hits	4
SwissProt Accessions	O00231, O00495	Gene names	PSMD11
Domain Architecture
Description	26S proteasome non-ATPase regulatory subunit 11 (26S proteasome regulatory subunit S9) (26S proteasome regulatory subunit p44.5).

REST_HUMAN
NC score	0.024055 (rank : 13)	θ value	0.365318 (rank : 5)
Query Neighborhood Hits	18	Target Neighborhood Hits	1605	Shared Neighborhood Hits	9
SwissProt Accessions	P30622	Gene names	RSN, CYLN1
Domain Architecture
Description	Restin (Cytoplasmic linker protein 170 alpha-2) (CLIP-170) (Reed- Sternberg intermediate filament-associated protein) (Cytoplasmic linker protein 1).

REST_MOUSE
NC score	0.021637 (rank : 14)	θ value	2.36792 (rank : 13)
Query Neighborhood Hits	18	Target Neighborhood Hits	1506	Shared Neighborhood Hits	10
SwissProt Accessions	Q922J3, Q571L7	Gene names	Rsn, Kiaa4046
Domain Architecture	No domain graphic available
Description	Restin.

MACF4_HUMAN
NC score	0.021143 (rank : 15)	θ value	5.27518 (rank : 14)
Query Neighborhood Hits	18	Target Neighborhood Hits	1321	Shared Neighborhood Hits	9
SwissProt Accessions	Q96PK2, Q8WXY1	Gene names	MACF1, ABP620, ACF7, KIAA0465, KIAA1251
Domain Architecture
Description	Microtubule-actin cross-linking factor 1, isoform 4.

MACF1_MOUSE
NC score	0.020929 (rank : 16)	θ value	2.36792 (rank : 12)
Query Neighborhood Hits	18	Target Neighborhood Hits	1313	Shared Neighborhood Hits	9
SwissProt Accessions	Q9QXZ0, P97394, P97395, P97396	Gene names	Macf1, Acf7, Aclp7, Macf
Domain Architecture
Description	Microtubule-actin cross-linking factor 1 (Actin cross-linking family 7).

APXL_HUMAN
NC score	0.012715 (rank : 17)	θ value	8.99809 (rank : 17)
Query Neighborhood Hits	18	Target Neighborhood Hits	553	Shared Neighborhood Hits	4
SwissProt Accessions	Q13796	Gene names	APXL
Domain Architecture
Description	Apical-like protein (Protein APXL).

UACA_MOUSE
NC score	0.010461 (rank : 18)	θ value	5.27518 (rank : 15)
Query Neighborhood Hits	18	Target Neighborhood Hits	1620	Shared Neighborhood Hits	8
SwissProt Accessions	Q8CGB3, Q69ZG3, Q7TN77, Q8BJC8	Gene names	Uaca, Kiaa1561
Domain Architecture	No domain graphic available
Description	Uveal autoantigen with coiled-coil domains and ankyrin repeats protein (Nucling) (Nuclear membrane-binding protein).

MYH14_MOUSE
NC score	0.006912 (rank : 19)	θ value	8.99809 (rank : 18)
Query Neighborhood Hits	18	Target Neighborhood Hits	1225	Shared Neighborhood Hits	7
SwissProt Accessions	Q6URW6, Q80V64, Q80ZE6	Gene names	Myh14
Domain Architecture	No domain graphic available
Description	Myosin-14 (Myosin heavy chain, nonmuscle IIc) (Nonmuscle myosin heavy chain IIc) (NMHC II-C).

AT11A_HUMAN
NC score	0.006711 (rank : 20)	θ value	6.88961 (rank : 16)
Query Neighborhood Hits	18	Target Neighborhood Hits	84	Shared Neighborhood Hits	2
SwissProt Accessions	P98196, Q5VXT2	Gene names	ATP11A, ATPIH, ATPIS, KIAA1021
Domain Architecture	No domain graphic available
Description	Probable phospholipid-transporting ATPase IH (EC 3.6.3.1) (ATPase class I type 11A) (ATPase IS).