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Network neighborhood for query Sequence : PRPS1_HUMAN

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PRPS1_HUMAN
SwissProt Accessions	P60891, P09329	Gene names	PRPS1
Domain Architecture
Description	Ribose-phosphate pyrophosphokinase I (EC 2.7.6.1) (Phosphoribosyl pyrophosphate synthetase I) (PRS-I) (PPRibP).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

PRPS1_HUMAN
θ value	1.27474e-179 (rank : 1)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	13	Target Neighborhood Hits	13	Shared Neighborhood Hits	13
SwissProt Accessions	P60891, P09329	Gene names	PRPS1
Domain Architecture
Description	Ribose-phosphate pyrophosphokinase I (EC 2.7.6.1) (Phosphoribosyl pyrophosphate synthetase I) (PRS-I) (PPRibP).

PRPS1_MOUSE
θ value	3.70894e-179 (rank : 2)	NC score	0.999954 (rank : 2)
Query Neighborhood Hits	13	Target Neighborhood Hits	13	Shared Neighborhood Hits	13
SwissProt Accessions	Q9D7G0	Gene names	Prps1
Domain Architecture
Description	Ribose-phosphate pyrophosphokinase I (EC 2.7.6.1) (Phosphoribosyl pyrophosphate synthetase I) (PRS-I).

PRPS2_MOUSE
θ value	1.50931e-172 (rank : 3)	NC score	0.999876 (rank : 3)
Query Neighborhood Hits	13	Target Neighborhood Hits	12	Shared Neighborhood Hits	12
SwissProt Accessions	Q9CS42, Q9CZA9	Gene names	Prps2
Domain Architecture
Description	Ribose-phosphate pyrophosphokinase II (EC 2.7.6.1) (Phosphoribosyl pyrophosphate synthetase II) (PRS-II).

PRPS2_HUMAN
θ value	1.97121e-172 (rank : 4)	NC score	0.999855 (rank : 4)
Query Neighborhood Hits	13	Target Neighborhood Hits	11	Shared Neighborhood Hits	11
SwissProt Accessions	P11908, Q15245	Gene names	PRPS2
Domain Architecture
Description	Ribose-phosphate pyrophosphokinase II (EC 2.7.6.1) (Phosphoribosyl pyrophosphate synthetase II) (PRS-II) (PPRibP).

PRPS3_HUMAN
θ value	5.93515e-169 (rank : 5)	NC score	0.999457 (rank : 5)
Query Neighborhood Hits	13	Target Neighborhood Hits	10	Shared Neighborhood Hits	10
SwissProt Accessions	P21108	Gene names	PRPS1L1, PRPS3
Domain Architecture
Description	Ribose-phosphate pyrophosphokinase III (EC 2.7.6.1) (Phosphoribosyl pyrophosphate synthetase III) (PRS-III) (Phosphoribosyl pyrophosphate synthetase 1-like 1).

KPRB_HUMAN
θ value	2.47765e-74 (rank : 6)	NC score	0.957261 (rank : 6)
Query Neighborhood Hits	13	Target Neighborhood Hits	11	Shared Neighborhood Hits	9
SwissProt Accessions	O60256	Gene names	PRPSAP2
Domain Architecture	No domain graphic available
Description	Phosphoribosyl pyrophosphate synthetase-associated protein 2 (PRPP synthetase-associated protein 2) (41 kDa phosphoribosypyrophosphate synthetase-associated protein) (PAP41).

KPRB_MOUSE
θ value	2.09745e-73 (rank : 7)	NC score	0.956361 (rank : 7)
Query Neighborhood Hits	13	Target Neighborhood Hits	12	Shared Neighborhood Hits	9
SwissProt Accessions	Q8R574	Gene names	Prpsap2
Domain Architecture	No domain graphic available
Description	Phosphoribosyl pyrophosphate synthetase-associated protein 2 (PRPP synthetase-associated protein 2) (41 kDa phosphoribosypyrophosphate synthetase-associated protein) (PAP41).

KPRA_HUMAN
θ value	5.34618e-69 (rank : 8)	NC score	0.953811 (rank : 8)
Query Neighborhood Hits	13	Target Neighborhood Hits	11	Shared Neighborhood Hits	9
SwissProt Accessions	Q14558, Q96H06	Gene names	PRPSAP1
Domain Architecture	No domain graphic available
Description	Phosphoribosyl pyrophosphate synthetase-associated protein 1 (PRPP synthetase-associated protein 1) (39 kDa phosphoribosypyrophosphate synthetase-associated protein) (PAP39).

KPRA_MOUSE
θ value	9.11921e-69 (rank : 9)	NC score	0.953664 (rank : 9)
Query Neighborhood Hits	13	Target Neighborhood Hits	11	Shared Neighborhood Hits	9
SwissProt Accessions	Q9D0M1	Gene names	Prpsap1
Domain Architecture	No domain graphic available
Description	Phosphoribosyl pyrophosphate synthetase-associated protein 1 (PRPP synthetase-associated protein 1) (39 kDa phosphoribosypyrophosphate synthetase-associated protein) (PAP39).

TCF25_MOUSE
θ value	0.813845 (rank : 10)	NC score	0.074914 (rank : 10)
Query Neighborhood Hits	13	Target Neighborhood Hits	21	Shared Neighborhood Hits	6
SwissProt Accessions	Q8R3L2, Q3THR8, Q3UBI7, Q3UD64, Q3UG75, Q80ZX3, Q8BR80, Q8C200, Q8C2M3, Q8C6B4, Q9CUW0, Q9ER19	Gene names	Tcf25, D8Ertd325e, Nulp1
Domain Architecture
Description	Transcription factor 25 (Nuclear localized protein 1).

TCF25_HUMAN
θ value	2.36792 (rank : 11)	NC score	0.061633 (rank : 11)
Query Neighborhood Hits	13	Target Neighborhood Hits	19	Shared Neighborhood Hits	6
SwissProt Accessions	Q9BQ70, Q2MK75, Q9UPV3	Gene names	TCF25, KIAA1049, NULP1
Domain Architecture
Description	Transcription factor 25 (Nuclear localized protein 1).

GBP4_HUMAN
θ value	8.99809 (rank : 12)	NC score	0.006547 (rank : 12)
Query Neighborhood Hits	13	Target Neighborhood Hits	484	Shared Neighborhood Hits	3
SwissProt Accessions	Q96PP9, Q86T99	Gene names	GBP4
Domain Architecture
Description	Guanylate-binding protein 4 (GTP-binding protein 4) (Guanine nucleotide-binding protein 4) (GBP-4).

ZEP1_HUMAN
θ value	8.99809 (rank : 13)	NC score	0.005489 (rank : 13)
Query Neighborhood Hits	13	Target Neighborhood Hits	1036	Shared Neighborhood Hits	5
SwissProt Accessions	P15822, Q14122	Gene names	HIVEP1, ZNF40
Domain Architecture	No domain graphic available
Description	Zinc finger protein 40 (Human immunodeficiency virus type I enhancer- binding protein 1) (HIV-EP1) (Major histocompatibility complex-binding protein 1) (MBP-1) (Positive regulatory domain II-binding factor 1) (PRDII-BF1).

Hits sorted by NC score

PRPS1_HUMAN
NC score	0.999962 (rank : 1)	θ value	1.27474e-179 (rank : 1)
Query Neighborhood Hits	13	Target Neighborhood Hits	13	Shared Neighborhood Hits	13
SwissProt Accessions	P60891, P09329	Gene names	PRPS1
Domain Architecture
Description	Ribose-phosphate pyrophosphokinase I (EC 2.7.6.1) (Phosphoribosyl pyrophosphate synthetase I) (PRS-I) (PPRibP).

PRPS1_MOUSE
NC score	0.999954 (rank : 2)	θ value	3.70894e-179 (rank : 2)
Query Neighborhood Hits	13	Target Neighborhood Hits	13	Shared Neighborhood Hits	13
SwissProt Accessions	Q9D7G0	Gene names	Prps1
Domain Architecture
Description	Ribose-phosphate pyrophosphokinase I (EC 2.7.6.1) (Phosphoribosyl pyrophosphate synthetase I) (PRS-I).

PRPS2_MOUSE
NC score	0.999876 (rank : 3)	θ value	1.50931e-172 (rank : 3)
Query Neighborhood Hits	13	Target Neighborhood Hits	12	Shared Neighborhood Hits	12
SwissProt Accessions	Q9CS42, Q9CZA9	Gene names	Prps2
Domain Architecture
Description	Ribose-phosphate pyrophosphokinase II (EC 2.7.6.1) (Phosphoribosyl pyrophosphate synthetase II) (PRS-II).

PRPS2_HUMAN
NC score	0.999855 (rank : 4)	θ value	1.97121e-172 (rank : 4)
Query Neighborhood Hits	13	Target Neighborhood Hits	11	Shared Neighborhood Hits	11
SwissProt Accessions	P11908, Q15245	Gene names	PRPS2
Domain Architecture
Description	Ribose-phosphate pyrophosphokinase II (EC 2.7.6.1) (Phosphoribosyl pyrophosphate synthetase II) (PRS-II) (PPRibP).

PRPS3_HUMAN
NC score	0.999457 (rank : 5)	θ value	5.93515e-169 (rank : 5)
Query Neighborhood Hits	13	Target Neighborhood Hits	10	Shared Neighborhood Hits	10
SwissProt Accessions	P21108	Gene names	PRPS1L1, PRPS3
Domain Architecture
Description	Ribose-phosphate pyrophosphokinase III (EC 2.7.6.1) (Phosphoribosyl pyrophosphate synthetase III) (PRS-III) (Phosphoribosyl pyrophosphate synthetase 1-like 1).

KPRB_HUMAN
NC score	0.957261 (rank : 6)	θ value	2.47765e-74 (rank : 6)
Query Neighborhood Hits	13	Target Neighborhood Hits	11	Shared Neighborhood Hits	9
SwissProt Accessions	O60256	Gene names	PRPSAP2
Domain Architecture	No domain graphic available
Description	Phosphoribosyl pyrophosphate synthetase-associated protein 2 (PRPP synthetase-associated protein 2) (41 kDa phosphoribosypyrophosphate synthetase-associated protein) (PAP41).

KPRB_MOUSE
NC score	0.956361 (rank : 7)	θ value	2.09745e-73 (rank : 7)
Query Neighborhood Hits	13	Target Neighborhood Hits	12	Shared Neighborhood Hits	9
SwissProt Accessions	Q8R574	Gene names	Prpsap2
Domain Architecture	No domain graphic available
Description	Phosphoribosyl pyrophosphate synthetase-associated protein 2 (PRPP synthetase-associated protein 2) (41 kDa phosphoribosypyrophosphate synthetase-associated protein) (PAP41).

KPRA_HUMAN
NC score	0.953811 (rank : 8)	θ value	5.34618e-69 (rank : 8)
Query Neighborhood Hits	13	Target Neighborhood Hits	11	Shared Neighborhood Hits	9
SwissProt Accessions	Q14558, Q96H06	Gene names	PRPSAP1
Domain Architecture	No domain graphic available
Description	Phosphoribosyl pyrophosphate synthetase-associated protein 1 (PRPP synthetase-associated protein 1) (39 kDa phosphoribosypyrophosphate synthetase-associated protein) (PAP39).

KPRA_MOUSE
NC score	0.953664 (rank : 9)	θ value	9.11921e-69 (rank : 9)
Query Neighborhood Hits	13	Target Neighborhood Hits	11	Shared Neighborhood Hits	9
SwissProt Accessions	Q9D0M1	Gene names	Prpsap1
Domain Architecture	No domain graphic available
Description	Phosphoribosyl pyrophosphate synthetase-associated protein 1 (PRPP synthetase-associated protein 1) (39 kDa phosphoribosypyrophosphate synthetase-associated protein) (PAP39).

TCF25_MOUSE
NC score	0.074914 (rank : 10)	θ value	0.813845 (rank : 10)
Query Neighborhood Hits	13	Target Neighborhood Hits	21	Shared Neighborhood Hits	6
SwissProt Accessions	Q8R3L2, Q3THR8, Q3UBI7, Q3UD64, Q3UG75, Q80ZX3, Q8BR80, Q8C200, Q8C2M3, Q8C6B4, Q9CUW0, Q9ER19	Gene names	Tcf25, D8Ertd325e, Nulp1
Domain Architecture
Description	Transcription factor 25 (Nuclear localized protein 1).

TCF25_HUMAN
NC score	0.061633 (rank : 11)	θ value	2.36792 (rank : 11)
Query Neighborhood Hits	13	Target Neighborhood Hits	19	Shared Neighborhood Hits	6
SwissProt Accessions	Q9BQ70, Q2MK75, Q9UPV3	Gene names	TCF25, KIAA1049, NULP1
Domain Architecture
Description	Transcription factor 25 (Nuclear localized protein 1).

GBP4_HUMAN
NC score	0.006547 (rank : 12)	θ value	8.99809 (rank : 12)
Query Neighborhood Hits	13	Target Neighborhood Hits	484	Shared Neighborhood Hits	3
SwissProt Accessions	Q96PP9, Q86T99	Gene names	GBP4
Domain Architecture
Description	Guanylate-binding protein 4 (GTP-binding protein 4) (Guanine nucleotide-binding protein 4) (GBP-4).

ZEP1_HUMAN
NC score	0.005489 (rank : 13)	θ value	8.99809 (rank : 13)
Query Neighborhood Hits	13	Target Neighborhood Hits	1036	Shared Neighborhood Hits	5
SwissProt Accessions	P15822, Q14122	Gene names	HIVEP1, ZNF40
Domain Architecture	No domain graphic available
Description	Zinc finger protein 40 (Human immunodeficiency virus type I enhancer- binding protein 1) (HIV-EP1) (Major histocompatibility complex-binding protein 1) (MBP-1) (Positive regulatory domain II-binding factor 1) (PRDII-BF1).