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Network neighborhood for query Sequence : PROK1_HUMAN

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PROK1_HUMAN
SwissProt Accessions	P58294	Gene names	PROK1
Domain Architecture
Description	Prokineticin-1 precursor (Endocrine-gland-derived vascular endothelial growth factor) (EG-VEGF) (Mambakine).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

PROK1_HUMAN
θ value	1.55911e-60 (rank : 1)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	16	Target Neighborhood Hits	16	Shared Neighborhood Hits	16
SwissProt Accessions	P58294	Gene names	PROK1
Domain Architecture
Description	Prokineticin-1 precursor (Endocrine-gland-derived vascular endothelial growth factor) (EG-VEGF) (Mambakine).

PROK2_HUMAN
θ value	1.16704e-23 (rank : 2)	NC score	0.913791 (rank : 2)
Query Neighborhood Hits	16	Target Neighborhood Hits	13	Shared Neighborhood Hits	11
SwissProt Accessions	Q9HC23	Gene names	PROK2, BV8
Domain Architecture
Description	Prokineticin-2 precursor (PK2) (Protein Bv8 homolog).

PROK2_MOUSE
θ value	1.29031e-22 (rank : 3)	NC score	0.911750 (rank : 3)
Query Neighborhood Hits	16	Target Neighborhood Hits	12	Shared Neighborhood Hits	11
SwissProt Accessions	Q9QXU7, Q9QXU5, Q9QXU6	Gene names	Prok2, Bv8
Domain Architecture
Description	Prokineticin-2 precursor (PK2) (Protein Bv8 homolog).

DKK4_MOUSE
θ value	0.000158464 (rank : 4)	NC score	0.463666 (rank : 4)
Query Neighborhood Hits	16	Target Neighborhood Hits	22	Shared Neighborhood Hits	11
SwissProt Accessions	Q8VEJ3	Gene names	Dkk4
Domain Architecture	No domain graphic available
Description	Dickkopf-related protein 4 precursor (Dkk-4) (Dickkopf-4).

DKK4_HUMAN
θ value	0.00020696 (rank : 5)	NC score	0.445378 (rank : 5)
Query Neighborhood Hits	16	Target Neighborhood Hits	25	Shared Neighborhood Hits	11
SwissProt Accessions	Q9UBT3, Q9Y4C3	Gene names	DKK4
Domain Architecture
Description	Dickkopf-related protein 4 precursor (Dkk-4) (Dickkopf-4) (hDkk-4) [Contains: Dickkopf-related protein 4 short form].

DKK2_HUMAN
θ value	0.00509761 (rank : 6)	NC score	0.394306 (rank : 8)
Query Neighborhood Hits	16	Target Neighborhood Hits	31	Shared Neighborhood Hits	11
SwissProt Accessions	Q9UBU2, Q9UIU3	Gene names	DKK2
Domain Architecture
Description	Dickkopf-related protein 2 precursor (Dkk-2) (Dickkopf-2) (hDkk-2).

DKK1_MOUSE
θ value	0.00665767 (rank : 7)	NC score	0.403390 (rank : 6)
Query Neighborhood Hits	16	Target Neighborhood Hits	28	Shared Neighborhood Hits	11
SwissProt Accessions	O54908	Gene names	Dkk1
Domain Architecture
Description	Dickkopf-related protein 1 precursor (Dkk-1) (Dickkopf-1) (mDkk-1).

DKK2_MOUSE
θ value	0.00665767 (rank : 8)	NC score	0.392973 (rank : 9)
Query Neighborhood Hits	16	Target Neighborhood Hits	34	Shared Neighborhood Hits	11
SwissProt Accessions	Q9QYZ8	Gene names	Dkk2
Domain Architecture
Description	Dickkopf-related protein 2 precursor (Dkk-2) (Dickkopf-2) (mDkk-2).

DKK3_HUMAN
θ value	0.00869519 (rank : 9)	NC score	0.326420 (rank : 10)
Query Neighborhood Hits	16	Target Neighborhood Hits	74	Shared Neighborhood Hits	11
SwissProt Accessions	Q9UBP4, Q9ULB7	Gene names	DKK3, REIC
Domain Architecture
Description	Dickkopf-related protein 3 precursor (Dkk-3) (Dickkopf-3) (hDkk-3).

DKK3_MOUSE
θ value	0.0148317 (rank : 10)	NC score	0.318574 (rank : 11)
Query Neighborhood Hits	16	Target Neighborhood Hits	83	Shared Neighborhood Hits	12
SwissProt Accessions	Q9QUN9	Gene names	Dkk3
Domain Architecture
Description	Dickkopf-related protein 3 precursor (Dkk-3) (Dickkopf-3) (mDkk-3).

DKK1_HUMAN
θ value	0.0193708 (rank : 11)	NC score	0.398784 (rank : 7)
Query Neighborhood Hits	16	Target Neighborhood Hits	24	Shared Neighborhood Hits	11
SwissProt Accessions	O94907	Gene names	DKK1
Domain Architecture
Description	Dickkopf-related protein 1 precursor (Dkk-1) (Dickkopf-1) (hDkk-1) (SK).

TMPS2_MOUSE
θ value	4.03905 (rank : 12)	NC score	0.007063 (rank : 16)
Query Neighborhood Hits	16	Target Neighborhood Hits	243	Shared Neighborhood Hits	3
SwissProt Accessions	Q9JIQ8, Q9JKC4, Q9QY82	Gene names	Tmprss2
Domain Architecture
Description	Transmembrane protease, serine 2 (EC 3.4.21.-) (Epitheliasin) (Plasmic transmembrane protein X) [Contains: Transmembrane protease, serine 2 non-catalytic chain; Transmembrane protease, serine 2 catalytic chain].

LRP1B_HUMAN
θ value	5.27518 (rank : 13)	NC score	0.009249 (rank : 14)
Query Neighborhood Hits	16	Target Neighborhood Hits	602	Shared Neighborhood Hits	5
SwissProt Accessions	Q9NZR2, Q8WY29, Q8WY30, Q8WY31	Gene names	LRP1B, LRPDIT
Domain Architecture
Description	Low-density lipoprotein receptor-related protein 1B precursor (Low- density lipoprotein receptor-related protein-deleted in tumor) (LRP- DIT).

TSP2_HUMAN
θ value	6.88961 (rank : 14)	NC score	0.007561 (rank : 15)
Query Neighborhood Hits	16	Target Neighborhood Hits	359	Shared Neighborhood Hits	2
SwissProt Accessions	P35442	Gene names	THBS2, TSP2
Domain Architecture
Description	Thrombospondin-2 precursor.

ADAM2_HUMAN
θ value	8.99809 (rank : 15)	NC score	0.006788 (rank : 17)
Query Neighborhood Hits	16	Target Neighborhood Hits	175	Shared Neighborhood Hits	3
SwissProt Accessions	Q99965, P78326, Q9UQQ8	Gene names	ADAM2, FTNB
Domain Architecture
Description	ADAM 2 precursor (A disintegrin and metalloproteinase domain 2) (Fertilin subunit beta) (PH-30) (PH30).

MA2A1_MOUSE
θ value	8.99809 (rank : 16)	NC score	0.013934 (rank : 13)
Query Neighborhood Hits	16	Target Neighborhood Hits	25	Shared Neighborhood Hits	2
SwissProt Accessions	P27046	Gene names	Man2a1, Mana2
Domain Architecture
Description	Alpha-mannosidase 2 (EC 3.2.1.114) (Alpha-mannosidase II) (Mannosyl- oligosaccharide 1,3-1,6-alpha-mannosidase) (MAN II) (Golgi alpha- mannosidase II) (Mannosidase alpha class 2A member 1) (AMAN II).

NICE1_HUMAN
θ value	θ > 10 (rank : 17)	NC score	0.078689 (rank : 12)
Query Neighborhood Hits	16	Target Neighborhood Hits	12	Shared Neighborhood Hits	2
SwissProt Accessions	Q9UGL9	Gene names	NICE1, C1orf42
Domain Architecture	No domain graphic available
Description	Protein NICE-1.

Hits sorted by NC score

PROK1_HUMAN
NC score	0.999962 (rank : 1)	θ value	1.55911e-60 (rank : 1)
Query Neighborhood Hits	16	Target Neighborhood Hits	16	Shared Neighborhood Hits	16
SwissProt Accessions	P58294	Gene names	PROK1
Domain Architecture
Description	Prokineticin-1 precursor (Endocrine-gland-derived vascular endothelial growth factor) (EG-VEGF) (Mambakine).

PROK2_HUMAN
NC score	0.913791 (rank : 2)	θ value	1.16704e-23 (rank : 2)
Query Neighborhood Hits	16	Target Neighborhood Hits	13	Shared Neighborhood Hits	11
SwissProt Accessions	Q9HC23	Gene names	PROK2, BV8
Domain Architecture
Description	Prokineticin-2 precursor (PK2) (Protein Bv8 homolog).

PROK2_MOUSE
NC score	0.911750 (rank : 3)	θ value	1.29031e-22 (rank : 3)
Query Neighborhood Hits	16	Target Neighborhood Hits	12	Shared Neighborhood Hits	11
SwissProt Accessions	Q9QXU7, Q9QXU5, Q9QXU6	Gene names	Prok2, Bv8
Domain Architecture
Description	Prokineticin-2 precursor (PK2) (Protein Bv8 homolog).

DKK4_MOUSE
NC score	0.463666 (rank : 4)	θ value	0.000158464 (rank : 4)
Query Neighborhood Hits	16	Target Neighborhood Hits	22	Shared Neighborhood Hits	11
SwissProt Accessions	Q8VEJ3	Gene names	Dkk4
Domain Architecture	No domain graphic available
Description	Dickkopf-related protein 4 precursor (Dkk-4) (Dickkopf-4).

DKK4_HUMAN
NC score	0.445378 (rank : 5)	θ value	0.00020696 (rank : 5)
Query Neighborhood Hits	16	Target Neighborhood Hits	25	Shared Neighborhood Hits	11
SwissProt Accessions	Q9UBT3, Q9Y4C3	Gene names	DKK4
Domain Architecture
Description	Dickkopf-related protein 4 precursor (Dkk-4) (Dickkopf-4) (hDkk-4) [Contains: Dickkopf-related protein 4 short form].

DKK1_MOUSE
NC score	0.403390 (rank : 6)	θ value	0.00665767 (rank : 7)
Query Neighborhood Hits	16	Target Neighborhood Hits	28	Shared Neighborhood Hits	11
SwissProt Accessions	O54908	Gene names	Dkk1
Domain Architecture
Description	Dickkopf-related protein 1 precursor (Dkk-1) (Dickkopf-1) (mDkk-1).

DKK1_HUMAN
NC score	0.398784 (rank : 7)	θ value	0.0193708 (rank : 11)
Query Neighborhood Hits	16	Target Neighborhood Hits	24	Shared Neighborhood Hits	11
SwissProt Accessions	O94907	Gene names	DKK1
Domain Architecture
Description	Dickkopf-related protein 1 precursor (Dkk-1) (Dickkopf-1) (hDkk-1) (SK).

DKK2_HUMAN
NC score	0.394306 (rank : 8)	θ value	0.00509761 (rank : 6)
Query Neighborhood Hits	16	Target Neighborhood Hits	31	Shared Neighborhood Hits	11
SwissProt Accessions	Q9UBU2, Q9UIU3	Gene names	DKK2
Domain Architecture
Description	Dickkopf-related protein 2 precursor (Dkk-2) (Dickkopf-2) (hDkk-2).

DKK2_MOUSE
NC score	0.392973 (rank : 9)	θ value	0.00665767 (rank : 8)
Query Neighborhood Hits	16	Target Neighborhood Hits	34	Shared Neighborhood Hits	11
SwissProt Accessions	Q9QYZ8	Gene names	Dkk2
Domain Architecture
Description	Dickkopf-related protein 2 precursor (Dkk-2) (Dickkopf-2) (mDkk-2).

DKK3_HUMAN
NC score	0.326420 (rank : 10)	θ value	0.00869519 (rank : 9)
Query Neighborhood Hits	16	Target Neighborhood Hits	74	Shared Neighborhood Hits	11
SwissProt Accessions	Q9UBP4, Q9ULB7	Gene names	DKK3, REIC
Domain Architecture
Description	Dickkopf-related protein 3 precursor (Dkk-3) (Dickkopf-3) (hDkk-3).

DKK3_MOUSE
NC score	0.318574 (rank : 11)	θ value	0.0148317 (rank : 10)
Query Neighborhood Hits	16	Target Neighborhood Hits	83	Shared Neighborhood Hits	12
SwissProt Accessions	Q9QUN9	Gene names	Dkk3
Domain Architecture
Description	Dickkopf-related protein 3 precursor (Dkk-3) (Dickkopf-3) (mDkk-3).

NICE1_HUMAN
NC score	0.078689 (rank : 12)	θ value	θ > 10 (rank : 17)
Query Neighborhood Hits	16	Target Neighborhood Hits	12	Shared Neighborhood Hits	2
SwissProt Accessions	Q9UGL9	Gene names	NICE1, C1orf42
Domain Architecture	No domain graphic available
Description	Protein NICE-1.

MA2A1_MOUSE
NC score	0.013934 (rank : 13)	θ value	8.99809 (rank : 16)
Query Neighborhood Hits	16	Target Neighborhood Hits	25	Shared Neighborhood Hits	2
SwissProt Accessions	P27046	Gene names	Man2a1, Mana2
Domain Architecture
Description	Alpha-mannosidase 2 (EC 3.2.1.114) (Alpha-mannosidase II) (Mannosyl- oligosaccharide 1,3-1,6-alpha-mannosidase) (MAN II) (Golgi alpha- mannosidase II) (Mannosidase alpha class 2A member 1) (AMAN II).

LRP1B_HUMAN
NC score	0.009249 (rank : 14)	θ value	5.27518 (rank : 13)
Query Neighborhood Hits	16	Target Neighborhood Hits	602	Shared Neighborhood Hits	5
SwissProt Accessions	Q9NZR2, Q8WY29, Q8WY30, Q8WY31	Gene names	LRP1B, LRPDIT
Domain Architecture
Description	Low-density lipoprotein receptor-related protein 1B precursor (Low- density lipoprotein receptor-related protein-deleted in tumor) (LRP- DIT).

TSP2_HUMAN
NC score	0.007561 (rank : 15)	θ value	6.88961 (rank : 14)
Query Neighborhood Hits	16	Target Neighborhood Hits	359	Shared Neighborhood Hits	2
SwissProt Accessions	P35442	Gene names	THBS2, TSP2
Domain Architecture
Description	Thrombospondin-2 precursor.

TMPS2_MOUSE
NC score	0.007063 (rank : 16)	θ value	4.03905 (rank : 12)
Query Neighborhood Hits	16	Target Neighborhood Hits	243	Shared Neighborhood Hits	3
SwissProt Accessions	Q9JIQ8, Q9JKC4, Q9QY82	Gene names	Tmprss2
Domain Architecture
Description	Transmembrane protease, serine 2 (EC 3.4.21.-) (Epitheliasin) (Plasmic transmembrane protein X) [Contains: Transmembrane protease, serine 2 non-catalytic chain; Transmembrane protease, serine 2 catalytic chain].

ADAM2_HUMAN
NC score	0.006788 (rank : 17)	θ value	8.99809 (rank : 15)
Query Neighborhood Hits	16	Target Neighborhood Hits	175	Shared Neighborhood Hits	3
SwissProt Accessions	Q99965, P78326, Q9UQQ8	Gene names	ADAM2, FTNB
Domain Architecture
Description	ADAM 2 precursor (A disintegrin and metalloproteinase domain 2) (Fertilin subunit beta) (PH-30) (PH30).