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Network neighborhood for query Sequence : PFD3_HUMAN

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PFD3_HUMAN
SwissProt Accessions	P61758, O55228, Q15765, Q5JT81, Q86X96	Gene names	VBP1, PFDN3
Domain Architecture
Description	Prefoldin subunit 3 (Von Hippel-Lindau-binding protein 1) (VHL-binding protein 1) (VBP-1) (HIBBJ46).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

PFD3_HUMAN
θ value	4.77967e-110 (rank : 1)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	24	Target Neighborhood Hits	24	Shared Neighborhood Hits	24
SwissProt Accessions	P61758, O55228, Q15765, Q5JT81, Q86X96	Gene names	VBP1, PFDN3
Domain Architecture
Description	Prefoldin subunit 3 (Von Hippel-Lindau-binding protein 1) (VHL-binding protein 1) (VBP-1) (HIBBJ46).

PFD3_MOUSE
θ value	6.0463e-105 (rank : 2)	NC score	0.998934 (rank : 2)
Query Neighborhood Hits	24	Target Neighborhood Hits	24	Shared Neighborhood Hits	22
SwissProt Accessions	P61759, O55228, Q15765, Q3U6M9, Q9CPZ0	Gene names	Vbp1, Pfdn3
Domain Architecture
Description	Prefoldin subunit 3 (Von Hippel-Lindau-binding protein 1) (VHL-binding protein 1) (VBP-1).

AKAP9_HUMAN
θ value	0.163984 (rank : 3)	NC score	0.048287 (rank : 9)
Query Neighborhood Hits	24	Target Neighborhood Hits	1710	Shared Neighborhood Hits	14
SwissProt Accessions	Q99996, O14869, O43355, O94895, Q9UQH3, Q9UQQ4, Q9Y6B8, Q9Y6Y2	Gene names	AKAP9, AKAP350, AKAP450, KIAA0803
Domain Architecture
Description	A-kinase anchor protein 9 (Protein kinase A-anchoring protein 9) (PRKA9) (A-kinase anchor protein 450 kDa) (AKAP 450) (A-kinase anchor protein 350 kDa) (AKAP 350) (hgAKAP 350) (AKAP 120-like protein) (Protein hyperion) (Protein yotiao) (Centrosome- and Golgi-localized PKN-associated protein) (CG-NAP).

SEPT3_HUMAN
θ value	0.813845 (rank : 4)	NC score	0.051688 (rank : 6)
Query Neighborhood Hits	24	Target Neighborhood Hits	56	Shared Neighborhood Hits	6
SwissProt Accessions	Q9UH03, Q6IBZ6, Q8N3P3	Gene names	SEPT3, SEP3
Domain Architecture
Description	Neuronal-specific septin-3.

SEPT3_MOUSE
θ value	0.813845 (rank : 5)	NC score	0.053324 (rank : 4)
Query Neighborhood Hits	24	Target Neighborhood Hits	56	Shared Neighborhood Hits	6
SwissProt Accessions	Q9Z1S5	Gene names	Sept3, Sep3
Domain Architecture
Description	Neuronal-specific septin-3.

HOOK1_HUMAN
θ value	1.06291 (rank : 6)	NC score	0.050285 (rank : 8)
Query Neighborhood Hits	24	Target Neighborhood Hits	942	Shared Neighborhood Hits	14
SwissProt Accessions	Q9UJC3, O60561, Q5TG44	Gene names	HOOK1
Domain Architecture
Description	Hook homolog 1 (h-hook1) (hHK1).

HOOK3_HUMAN
θ value	1.06291 (rank : 7)	NC score	0.050879 (rank : 7)
Query Neighborhood Hits	24	Target Neighborhood Hits	1070	Shared Neighborhood Hits	13
SwissProt Accessions	Q86VS8, Q8NBH0, Q9BY13	Gene names	HOOK3
Domain Architecture
Description	Hook homolog 3 (hHK3).

HOOK3_MOUSE
θ value	1.06291 (rank : 8)	NC score	0.052795 (rank : 5)
Query Neighborhood Hits	24	Target Neighborhood Hits	1007	Shared Neighborhood Hits	13
SwissProt Accessions	Q8BUK6, Q8BV48, Q8BW57, Q8BY41	Gene names	Hook3
Domain Architecture
Description	Hook homolog 3.

UXT_MOUSE
θ value	1.06291 (rank : 9)	NC score	0.097801 (rank : 3)
Query Neighborhood Hits	24	Target Neighborhood Hits	4	Shared Neighborhood Hits	3
SwissProt Accessions	Q9WTZ0	Gene names	Uxt
Domain Architecture
Description	Protein UXT (Ubiquitously expressed transcript protein).

MYH10_HUMAN
θ value	1.38821 (rank : 10)	NC score	0.030488 (rank : 12)
Query Neighborhood Hits	24	Target Neighborhood Hits	1620	Shared Neighborhood Hits	14
SwissProt Accessions	P35580, Q16087	Gene names	MYH10
Domain Architecture
Description	Myosin-10 (Myosin heavy chain, nonmuscle IIb) (Nonmuscle myosin heavy chain IIb) (NMMHC II-b) (NMMHC-IIB) (Cellular myosin heavy chain, type B) (Nonmuscle myosin heavy chain-B) (NMMHC-B).

MYH10_MOUSE
θ value	1.81305 (rank : 11)	NC score	0.030088 (rank : 13)
Query Neighborhood Hits	24	Target Neighborhood Hits	1612	Shared Neighborhood Hits	14
SwissProt Accessions	Q61879, Q5SV63	Gene names	Myh10
Domain Architecture	No domain graphic available
Description	Myosin-10 (Myosin heavy chain, nonmuscle IIb) (Nonmuscle myosin heavy chain IIb) (NMMHC II-b) (NMMHC-IIB) (Cellular myosin heavy chain, type B) (Nonmuscle myosin heavy chain-B) (NMMHC-B).

ROCK1_HUMAN
θ value	2.36792 (rank : 12)	NC score	0.016739 (rank : 20)
Query Neighborhood Hits	24	Target Neighborhood Hits	2000	Shared Neighborhood Hits	13
SwissProt Accessions	Q13464	Gene names	ROCK1
Domain Architecture
Description	Rho-associated protein kinase 1 (EC 2.7.11.1) (Rho-associated, coiled- coil-containing protein kinase 1) (p160 ROCK-1) (p160ROCK) (NY-REN-35 antigen).

5HT2A_HUMAN
θ value	3.0926 (rank : 13)	NC score	0.007606 (rank : 24)
Query Neighborhood Hits	24	Target Neighborhood Hits	937	Shared Neighborhood Hits	3
SwissProt Accessions	P28223	Gene names	HTR2A, HTR2
Domain Architecture
Description	5-hydroxytryptamine 2A receptor (5-HT-2A) (Serotonin receptor 2A) (5- HT-2).

MYH11_HUMAN
θ value	5.27518 (rank : 14)	NC score	0.026732 (rank : 15)
Query Neighborhood Hits	24	Target Neighborhood Hits	1806	Shared Neighborhood Hits	14
SwissProt Accessions	P35749, O00396, O94944, P78422	Gene names	MYH11, KIAA0866
Domain Architecture
Description	Myosin-11 (Myosin heavy chain, smooth muscle isoform) (SMMHC).

PO4F3_HUMAN
θ value	5.27518 (rank : 15)	NC score	0.016060 (rank : 21)
Query Neighborhood Hits	24	Target Neighborhood Hits	307	Shared Neighborhood Hits	3
SwissProt Accessions	Q15319, O60557	Gene names	POU4F3, BRN3C
Domain Architecture
Description	POU domain, class 4, transcription factor 3 (Brain-specific homeobox/POU domain protein 3C) (Brn-3C).

PO4F3_MOUSE
θ value	5.27518 (rank : 16)	NC score	0.016056 (rank : 22)
Query Neighborhood Hits	24	Target Neighborhood Hits	311	Shared Neighborhood Hits	3
SwissProt Accessions	Q63955	Gene names	Pou4f3, Brn-3c, Brn3c
Domain Architecture
Description	POU domain, class 4, transcription factor 3 (Brain-specific homeobox/POU domain protein 3C) (Brn-3C).

EEA1_HUMAN
θ value	6.88961 (rank : 17)	NC score	0.023844 (rank : 17)
Query Neighborhood Hits	24	Target Neighborhood Hits	1796	Shared Neighborhood Hits	14
SwissProt Accessions	Q15075, Q14221	Gene names	EEA1, ZFYVE2
Domain Architecture
Description	Early endosome antigen 1 (Endosome-associated protein p162) (Zinc finger FYVE domain-containing protein 2).

OXR1_MOUSE
θ value	6.88961 (rank : 18)	NC score	0.028197 (rank : 14)
Query Neighborhood Hits	24	Target Neighborhood Hits	516	Shared Neighborhood Hits	10
SwissProt Accessions	Q4KMM3, Q5FWW1, Q99L06, Q99MK1, Q99MP4	Gene names	Oxr1, C7
Domain Architecture	No domain graphic available
Description	Oxidation resistance protein 1 (Protein C7).

ROCK1_MOUSE
θ value	6.88961 (rank : 19)	NC score	0.015396 (rank : 23)
Query Neighborhood Hits	24	Target Neighborhood Hits	2126	Shared Neighborhood Hits	14
SwissProt Accessions	P70335, Q8C3G4, Q8C7H0	Gene names	Rock1
Domain Architecture
Description	Rho-associated protein kinase 1 (EC 2.7.11.1) (Rho-associated, coiled- coil-containing protein kinase 1) (p160 ROCK-1) (p160ROCK).

SPAST_HUMAN
θ value	6.88961 (rank : 20)	NC score	0.017878 (rank : 18)
Query Neighborhood Hits	24	Target Neighborhood Hits	100	Shared Neighborhood Hits	4
SwissProt Accessions	Q9UBP0, Q9UPR9	Gene names	SPAST, KIAA1083, SPG4
Domain Architecture
Description	Spastin.

SPAST_MOUSE
θ value	6.88961 (rank : 21)	NC score	0.017768 (rank : 19)
Query Neighborhood Hits	24	Target Neighborhood Hits	138	Shared Neighborhood Hits	4
SwissProt Accessions	Q9QYY8, Q6ZPY6, Q80VE0, Q9CVK0	Gene names	Spast, Kiaa1083, Spg4
Domain Architecture	No domain graphic available
Description	Spastin.

MYH11_MOUSE
θ value	8.99809 (rank : 22)	NC score	0.025598 (rank : 16)
Query Neighborhood Hits	24	Target Neighborhood Hits	1777	Shared Neighborhood Hits	13
SwissProt Accessions	O08638, O08639, Q62462, Q64195	Gene names	Myh11
Domain Architecture
Description	Myosin-11 (Myosin heavy chain, smooth muscle isoform) (SMMHC).

SEPT9_HUMAN
θ value	8.99809 (rank : 23)	NC score	0.032979 (rank : 11)
Query Neighborhood Hits	24	Target Neighborhood Hits	706	Shared Neighborhood Hits	6
SwissProt Accessions	Q9UHD8, Q96QF3, Q96QF4, Q96QF5, Q9HA04, Q9UG40, Q9Y5W4	Gene names	SEPT9, KIAA0991, MSF
Domain Architecture	No domain graphic available
Description	Septin-9 (MLL septin-like fusion protein) (MLL septin-like fusion protein MSF-A) (Ovarian/Breast septin) (Ov/Br septin) (Septin D1).

SEPT9_MOUSE
θ value	8.99809 (rank : 24)	NC score	0.035761 (rank : 10)
Query Neighborhood Hits	24	Target Neighborhood Hits	238	Shared Neighborhood Hits	6
SwissProt Accessions	Q80UG5, Q3URP2, Q80TM7, Q9QYX9	Gene names	Sept9, Kiaa0991, Sint1
Domain Architecture	No domain graphic available
Description	Septin-9 (SL3-3 integration site 1 protein).

Hits sorted by NC score

PFD3_HUMAN
NC score	0.999962 (rank : 1)	θ value	4.77967e-110 (rank : 1)
Query Neighborhood Hits	24	Target Neighborhood Hits	24	Shared Neighborhood Hits	24
SwissProt Accessions	P61758, O55228, Q15765, Q5JT81, Q86X96	Gene names	VBP1, PFDN3
Domain Architecture
Description	Prefoldin subunit 3 (Von Hippel-Lindau-binding protein 1) (VHL-binding protein 1) (VBP-1) (HIBBJ46).

PFD3_MOUSE
NC score	0.998934 (rank : 2)	θ value	6.0463e-105 (rank : 2)
Query Neighborhood Hits	24	Target Neighborhood Hits	24	Shared Neighborhood Hits	22
SwissProt Accessions	P61759, O55228, Q15765, Q3U6M9, Q9CPZ0	Gene names	Vbp1, Pfdn3
Domain Architecture
Description	Prefoldin subunit 3 (Von Hippel-Lindau-binding protein 1) (VHL-binding protein 1) (VBP-1).

UXT_MOUSE
NC score	0.097801 (rank : 3)	θ value	1.06291 (rank : 9)
Query Neighborhood Hits	24	Target Neighborhood Hits	4	Shared Neighborhood Hits	3
SwissProt Accessions	Q9WTZ0	Gene names	Uxt
Domain Architecture
Description	Protein UXT (Ubiquitously expressed transcript protein).

SEPT3_MOUSE
NC score	0.053324 (rank : 4)	θ value	0.813845 (rank : 5)
Query Neighborhood Hits	24	Target Neighborhood Hits	56	Shared Neighborhood Hits	6
SwissProt Accessions	Q9Z1S5	Gene names	Sept3, Sep3
Domain Architecture
Description	Neuronal-specific septin-3.

HOOK3_MOUSE
NC score	0.052795 (rank : 5)	θ value	1.06291 (rank : 8)
Query Neighborhood Hits	24	Target Neighborhood Hits	1007	Shared Neighborhood Hits	13
SwissProt Accessions	Q8BUK6, Q8BV48, Q8BW57, Q8BY41	Gene names	Hook3
Domain Architecture
Description	Hook homolog 3.

SEPT3_HUMAN
NC score	0.051688 (rank : 6)	θ value	0.813845 (rank : 4)
Query Neighborhood Hits	24	Target Neighborhood Hits	56	Shared Neighborhood Hits	6
SwissProt Accessions	Q9UH03, Q6IBZ6, Q8N3P3	Gene names	SEPT3, SEP3
Domain Architecture
Description	Neuronal-specific septin-3.

HOOK3_HUMAN
NC score	0.050879 (rank : 7)	θ value	1.06291 (rank : 7)
Query Neighborhood Hits	24	Target Neighborhood Hits	1070	Shared Neighborhood Hits	13
SwissProt Accessions	Q86VS8, Q8NBH0, Q9BY13	Gene names	HOOK3
Domain Architecture
Description	Hook homolog 3 (hHK3).

HOOK1_HUMAN
NC score	0.050285 (rank : 8)	θ value	1.06291 (rank : 6)
Query Neighborhood Hits	24	Target Neighborhood Hits	942	Shared Neighborhood Hits	14
SwissProt Accessions	Q9UJC3, O60561, Q5TG44	Gene names	HOOK1
Domain Architecture
Description	Hook homolog 1 (h-hook1) (hHK1).

AKAP9_HUMAN
NC score	0.048287 (rank : 9)	θ value	0.163984 (rank : 3)
Query Neighborhood Hits	24	Target Neighborhood Hits	1710	Shared Neighborhood Hits	14
SwissProt Accessions	Q99996, O14869, O43355, O94895, Q9UQH3, Q9UQQ4, Q9Y6B8, Q9Y6Y2	Gene names	AKAP9, AKAP350, AKAP450, KIAA0803
Domain Architecture
Description	A-kinase anchor protein 9 (Protein kinase A-anchoring protein 9) (PRKA9) (A-kinase anchor protein 450 kDa) (AKAP 450) (A-kinase anchor protein 350 kDa) (AKAP 350) (hgAKAP 350) (AKAP 120-like protein) (Protein hyperion) (Protein yotiao) (Centrosome- and Golgi-localized PKN-associated protein) (CG-NAP).

SEPT9_MOUSE
NC score	0.035761 (rank : 10)	θ value	8.99809 (rank : 24)
Query Neighborhood Hits	24	Target Neighborhood Hits	238	Shared Neighborhood Hits	6
SwissProt Accessions	Q80UG5, Q3URP2, Q80TM7, Q9QYX9	Gene names	Sept9, Kiaa0991, Sint1
Domain Architecture	No domain graphic available
Description	Septin-9 (SL3-3 integration site 1 protein).

SEPT9_HUMAN
NC score	0.032979 (rank : 11)	θ value	8.99809 (rank : 23)
Query Neighborhood Hits	24	Target Neighborhood Hits	706	Shared Neighborhood Hits	6
SwissProt Accessions	Q9UHD8, Q96QF3, Q96QF4, Q96QF5, Q9HA04, Q9UG40, Q9Y5W4	Gene names	SEPT9, KIAA0991, MSF
Domain Architecture	No domain graphic available
Description	Septin-9 (MLL septin-like fusion protein) (MLL septin-like fusion protein MSF-A) (Ovarian/Breast septin) (Ov/Br septin) (Septin D1).

MYH10_HUMAN
NC score	0.030488 (rank : 12)	θ value	1.38821 (rank : 10)
Query Neighborhood Hits	24	Target Neighborhood Hits	1620	Shared Neighborhood Hits	14
SwissProt Accessions	P35580, Q16087	Gene names	MYH10
Domain Architecture
Description	Myosin-10 (Myosin heavy chain, nonmuscle IIb) (Nonmuscle myosin heavy chain IIb) (NMMHC II-b) (NMMHC-IIB) (Cellular myosin heavy chain, type B) (Nonmuscle myosin heavy chain-B) (NMMHC-B).

MYH10_MOUSE
NC score	0.030088 (rank : 13)	θ value	1.81305 (rank : 11)
Query Neighborhood Hits	24	Target Neighborhood Hits	1612	Shared Neighborhood Hits	14
SwissProt Accessions	Q61879, Q5SV63	Gene names	Myh10
Domain Architecture	No domain graphic available
Description	Myosin-10 (Myosin heavy chain, nonmuscle IIb) (Nonmuscle myosin heavy chain IIb) (NMMHC II-b) (NMMHC-IIB) (Cellular myosin heavy chain, type B) (Nonmuscle myosin heavy chain-B) (NMMHC-B).

OXR1_MOUSE
NC score	0.028197 (rank : 14)	θ value	6.88961 (rank : 18)
Query Neighborhood Hits	24	Target Neighborhood Hits	516	Shared Neighborhood Hits	10
SwissProt Accessions	Q4KMM3, Q5FWW1, Q99L06, Q99MK1, Q99MP4	Gene names	Oxr1, C7
Domain Architecture	No domain graphic available
Description	Oxidation resistance protein 1 (Protein C7).

MYH11_HUMAN
NC score	0.026732 (rank : 15)	θ value	5.27518 (rank : 14)
Query Neighborhood Hits	24	Target Neighborhood Hits	1806	Shared Neighborhood Hits	14
SwissProt Accessions	P35749, O00396, O94944, P78422	Gene names	MYH11, KIAA0866
Domain Architecture
Description	Myosin-11 (Myosin heavy chain, smooth muscle isoform) (SMMHC).

MYH11_MOUSE
NC score	0.025598 (rank : 16)	θ value	8.99809 (rank : 22)
Query Neighborhood Hits	24	Target Neighborhood Hits	1777	Shared Neighborhood Hits	13
SwissProt Accessions	O08638, O08639, Q62462, Q64195	Gene names	Myh11
Domain Architecture
Description	Myosin-11 (Myosin heavy chain, smooth muscle isoform) (SMMHC).

EEA1_HUMAN
NC score	0.023844 (rank : 17)	θ value	6.88961 (rank : 17)
Query Neighborhood Hits	24	Target Neighborhood Hits	1796	Shared Neighborhood Hits	14
SwissProt Accessions	Q15075, Q14221	Gene names	EEA1, ZFYVE2
Domain Architecture
Description	Early endosome antigen 1 (Endosome-associated protein p162) (Zinc finger FYVE domain-containing protein 2).

SPAST_HUMAN
NC score	0.017878 (rank : 18)	θ value	6.88961 (rank : 20)
Query Neighborhood Hits	24	Target Neighborhood Hits	100	Shared Neighborhood Hits	4
SwissProt Accessions	Q9UBP0, Q9UPR9	Gene names	SPAST, KIAA1083, SPG4
Domain Architecture
Description	Spastin.

SPAST_MOUSE
NC score	0.017768 (rank : 19)	θ value	6.88961 (rank : 21)
Query Neighborhood Hits	24	Target Neighborhood Hits	138	Shared Neighborhood Hits	4
SwissProt Accessions	Q9QYY8, Q6ZPY6, Q80VE0, Q9CVK0	Gene names	Spast, Kiaa1083, Spg4
Domain Architecture	No domain graphic available
Description	Spastin.

ROCK1_HUMAN
NC score	0.016739 (rank : 20)	θ value	2.36792 (rank : 12)
Query Neighborhood Hits	24	Target Neighborhood Hits	2000	Shared Neighborhood Hits	13
SwissProt Accessions	Q13464	Gene names	ROCK1
Domain Architecture
Description	Rho-associated protein kinase 1 (EC 2.7.11.1) (Rho-associated, coiled- coil-containing protein kinase 1) (p160 ROCK-1) (p160ROCK) (NY-REN-35 antigen).

PO4F3_HUMAN
NC score	0.016060 (rank : 21)	θ value	5.27518 (rank : 15)
Query Neighborhood Hits	24	Target Neighborhood Hits	307	Shared Neighborhood Hits	3
SwissProt Accessions	Q15319, O60557	Gene names	POU4F3, BRN3C
Domain Architecture
Description	POU domain, class 4, transcription factor 3 (Brain-specific homeobox/POU domain protein 3C) (Brn-3C).

PO4F3_MOUSE
NC score	0.016056 (rank : 22)	θ value	5.27518 (rank : 16)
Query Neighborhood Hits	24	Target Neighborhood Hits	311	Shared Neighborhood Hits	3
SwissProt Accessions	Q63955	Gene names	Pou4f3, Brn-3c, Brn3c
Domain Architecture
Description	POU domain, class 4, transcription factor 3 (Brain-specific homeobox/POU domain protein 3C) (Brn-3C).

ROCK1_MOUSE
NC score	0.015396 (rank : 23)	θ value	6.88961 (rank : 19)
Query Neighborhood Hits	24	Target Neighborhood Hits	2126	Shared Neighborhood Hits	14
SwissProt Accessions	P70335, Q8C3G4, Q8C7H0	Gene names	Rock1
Domain Architecture
Description	Rho-associated protein kinase 1 (EC 2.7.11.1) (Rho-associated, coiled- coil-containing protein kinase 1) (p160 ROCK-1) (p160ROCK).

5HT2A_HUMAN
NC score	0.007606 (rank : 24)	θ value	3.0926 (rank : 13)
Query Neighborhood Hits	24	Target Neighborhood Hits	937	Shared Neighborhood Hits	3
SwissProt Accessions	P28223	Gene names	HTR2A, HTR2
Domain Architecture
Description	5-hydroxytryptamine 2A receptor (5-HT-2A) (Serotonin receptor 2A) (5- HT-2).